Reye's Syndrome - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

REYE’S

SYNDROME A M EDICAL D ICTIONARY , B IBLIOGRAPHY , AND A NNOTATED R ESEARCH G UIDE TO I NTERNET R E FERENCES

J AMES N. P ARKER , M.D. AND P HILIP M. P ARKER , P H .D., E DITORS

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ICON Health Publications ICON Group International, Inc. 4370 La Jolla Village Drive, 4th Floor San Diego, CA 92122 USA Copyright 2003 by ICON Group International, Inc. Copyright 2003 by ICON Group International, Inc. All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without written permission from the publisher. Printed in the United States of America. Last digit indicates print number: 10 9 8 7 6 4 5 3 2 1

Publisher, Health Care: Philip Parker, Ph.D. Editor(s): James Parker, M.D., Philip Parker, Ph.D. Publisher's note: The ideas, procedures, and suggestions contained in this book are not intended for the diagnosis or treatment of a health problem. As new medical or scientific information becomes available from academic and clinical research, recommended treatments and drug therapies may undergo changes. The authors, editors, and publisher have attempted to make the information in this book up to date and accurate in accord with accepted standards at the time of publication. The authors, editors, and publisher are not responsible for errors or omissions or for consequences from application of the book, and make no warranty, expressed or implied, in regard to the contents of this book. Any practice described in this book should be applied by the reader in accordance with professional standards of care used in regard to the unique circumstances that may apply in each situation. The reader is advised to always check product information (package inserts) for changes and new information regarding dosage and contraindications before prescribing any drug or pharmacological product. Caution is especially urged when using new or infrequently ordered drugs, herbal remedies, vitamins and supplements, alternative therapies, complementary therapies and medicines, and integrative medical treatments. Cataloging-in-Publication Data Parker, James N., 1961Parker, Philip M., 1960Reye’s Syndrome: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References / James N. Parker and Philip M. Parker, editors p. cm. Includes bibliographical references, glossary, and index. ISBN: 0-597-83667-1 1. Reye’s Syndrome-Popular works. I. Title.

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Disclaimer This publication is not intended to be used for the diagnosis or treatment of a health problem. It is sold with the understanding that the publisher, editors, and authors are not engaging in the rendering of medical, psychological, financial, legal, or other professional services. References to any entity, product, service, or source of information that may be contained in this publication should not be considered an endorsement, either direct or implied, by the publisher, editors, or authors. ICON Group International, Inc., the editors, and the authors are not responsible for the content of any Web pages or publications referenced in this publication.

Copyright Notice If a physician wishes to copy limited passages from this book for patient use, this right is automatically granted without written permission from ICON Group International, Inc. (ICON Group). However, all of ICON Group publications have copyrights. With exception to the above, copying our publications in whole or in part, for whatever reason, is a violation of copyright laws and can lead to penalties and fines. Should you want to copy tables, graphs, or other materials, please contact us to request permission (E-mail: [email protected]). ICON Group often grants permission for very limited reproduction of our publications for internal use, press releases, and academic research. Such reproduction requires confirmed permission from ICON Group International Inc. The disclaimer above must accompany all reproductions, in whole or in part, of this book.

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Acknowledgements The collective knowledge generated from academic and applied research summarized in various references has been critical in the creation of this book which is best viewed as a comprehensive compilation and collection of information prepared by various official agencies which produce publications on Reye’s syndrome. Books in this series draw from various agencies and institutions associated with the United States Department of Health and Human Services, and in particular, the Office of the Secretary of Health and Human Services (OS), the Administration for Children and Families (ACF), the Administration on Aging (AOA), the Agency for Healthcare Research and Quality (AHRQ), the Agency for Toxic Substances and Disease Registry (ATSDR), the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), the Healthcare Financing Administration (HCFA), the Health Resources and Services Administration (HRSA), the Indian Health Service (IHS), the institutions of the National Institutes of Health (NIH), the Program Support Center (PSC), and the Substance Abuse and Mental Health Services Administration (SAMHSA). In addition to these sources, information gathered from the National Library of Medicine, the United States Patent Office, the European Union, and their related organizations has been invaluable in the creation of this book. Some of the work represented was financially supported by the Research and Development Committee at INSEAD. This support is gratefully acknowledged. Finally, special thanks are owed to Tiffany Freeman for her excellent editorial support.

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About the Editors James N. Parker, M.D. Dr. James N. Parker received his Bachelor of Science degree in Psychobiology from the University of California, Riverside and his M.D. from the University of California, San Diego. In addition to authoring numerous research publications, he has lectured at various academic institutions. Dr. Parker is the medical editor for health books by ICON Health Publications. Philip M. Parker, Ph.D. Philip M. Parker is the Eli Lilly Chair Professor of Innovation, Business and Society at INSEAD (Fontainebleau, France and Singapore). Dr. Parker has also been Professor at the University of California, San Diego and has taught courses at Harvard University, the Hong Kong University of Science and Technology, the Massachusetts Institute of Technology, Stanford University, and UCLA. Dr. Parker is the associate editor for ICON Health Publications.

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About ICON Health Publications To discover more about ICON Health Publications, simply check with your preferred online booksellers, including Barnes & Noble.com and Amazon.com which currently carry all of our titles. Or, feel free to contact us directly for bulk purchases or institutional discounts: ICON Group International, Inc. 4370 La Jolla Village Drive, Fourth Floor San Diego, CA 92122 USA Fax: 858-546-4341 Web site: www.icongrouponline.com/health

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Table of Contents FORWARD .......................................................................................................................................... 1 CHAPTER 1. STUDIES ON REYE’S SYNDROME ................................................................................... 3 Overview........................................................................................................................................ 3 Federally Funded Research on Reye’s Syndrome........................................................................... 3 E-Journals: PubMed Central ......................................................................................................... 6 The National Library of Medicine: PubMed .................................................................................. 6 CHAPTER 2. NUTRITION AND REYE’S SYNDROME.......................................................................... 93 Overview...................................................................................................................................... 93 Finding Nutrition Studies on Reye’s Syndrome.......................................................................... 93 Federal Resources on Nutrition ................................................................................................... 96 Additional Web Resources ........................................................................................................... 96 CHAPTER 3. ALTERNATIVE MEDICINE AND REYE’S SYNDROME ................................................... 97 Overview...................................................................................................................................... 97 National Center for Complementary and Alternative Medicine.................................................. 97 Additional Web Resources ........................................................................................................... 99 General References ..................................................................................................................... 101 CHAPTER 4. BOOKS ON REYE’S SYNDROME .................................................................................. 103 Overview.................................................................................................................................... 103 Book Summaries: Online Booksellers......................................................................................... 103 The National Library of Medicine Book Index ........................................................................... 104 Chapters on Reye’s Syndrome.................................................................................................... 104 CHAPTER 5. MULTIMEDIA ON REYE’S SYNDROME ....................................................................... 107 Overview.................................................................................................................................... 107 Bibliography: Multimedia on Reye’s Syndrome ........................................................................ 107 APPENDIX A. PHYSICIAN RESOURCES .......................................................................................... 111 Overview.................................................................................................................................... 111 NIH Guidelines.......................................................................................................................... 111 NIH Databases........................................................................................................................... 113 Other Commercial Databases..................................................................................................... 115 APPENDIX B. PATIENT RESOURCES ............................................................................................... 117 Overview.................................................................................................................................... 117 Patient Guideline Sources.......................................................................................................... 117 Associations and Reye’s Syndrome............................................................................................ 120 Finding Associations.................................................................................................................. 122 APPENDIX C. FINDING MEDICAL LIBRARIES ................................................................................ 125 Overview.................................................................................................................................... 125 Preparation................................................................................................................................. 125 Finding a Local Medical Library................................................................................................ 125 Medical Libraries in the U.S. and Canada ................................................................................. 125 ONLINE GLOSSARIES................................................................................................................ 131 Online Dictionary Directories ................................................................................................... 135 REYE’S SYNDROME DICTIONARY ........................................................................................ 137 INDEX .............................................................................................................................................. 171

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FORWARD In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."1 Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing. Since only the smallest fraction of information dealing with Reye’s syndrome is indexed in search engines, such as www.google.com or others, a non-systematic approach to Internet research can be not only time consuming, but also incomplete. This book was created for medical professionals, students, and members of the general public who want to know as much as possible about Reye’s syndrome, using the most advanced research tools available and spending the least amount of time doing so. In addition to offering a structured and comprehensive bibliography, the pages that follow will tell you where and how to find reliable information covering virtually all topics related to Reye’s syndrome, from the essentials to the most advanced areas of research. Public, academic, government, and peer-reviewed research studies are emphasized. Various abstracts are reproduced to give you some of the latest official information available to date on Reye’s syndrome. Abundant guidance is given on how to obtain free-of-charge primary research results via the Internet. While this book focuses on the field of medicine, when some sources provide access to non-medical information relating to Reye’s syndrome, these are noted in the text. E-book and electronic versions of this book are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). If you are using the hard copy version of this book, you can access a cited Web site by typing the provided Web address directly into your Internet browser. You may find it useful to refer to synonyms or related terms when accessing these Internet databases. NOTE: At the time of publication, the Web addresses were functional. However, some links may fail due to URL address changes, which is a common occurrence on the Internet. For readers unfamiliar with the Internet, detailed instructions are offered on how to access electronic resources. For readers unfamiliar with medical terminology, a comprehensive glossary is provided. For readers without access to Internet resources, a directory of medical libraries, that have or can locate references cited here, is given. We hope these resources will prove useful to the widest possible audience seeking information on Reye’s syndrome. The Editors

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From the NIH, National Cancer Institute (NCI): http://www.cancer.gov/cancerinfo/ten-things-to-know.

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CHAPTER 1. STUDIES ON REYE’S SYNDROME Overview In this chapter, we will show you how to locate peer-reviewed references and studies on Reye’s syndrome.

Federally Funded Research on Reye’s Syndrome The U.S. Government supports a variety of research studies relating to Reye’s syndrome. These studies are tracked by the Office of Extramural Research at the National Institutes of Health.2 CRISP (Computerized Retrieval of Information on Scientific Projects) is a searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other institutions. Search the CRISP Web site at http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen. You will have the option to perform targeted searches by various criteria, including geography, date, and topics related to Reye’s syndrome. For most of the studies, the agencies reporting into CRISP provide summaries or abstracts. As opposed to clinical trial research using patients, many federally funded studies use animals or simulated models to explore Reye’s syndrome. The following is typical of the type of information found when searching the CRISP database for Reye’s syndrome: •

Project Title: CATALYSIS AND REGULATION OF THE UREA CYCLE Principal Investigator & Institution: Powers-Lee, Susan G.; Professor; Biology; Northeastern University 360 Huntington Ave Boston, MA 02115 Timing: Fiscal Year 2001; Project Start 01-SEP-1998; Project End 30-JUN-2003 Summary: Control mechanisms are of crucial importance for the maintenance of normal metabolism and a knowledge of the molecular details of the mechanisms that regulate metabolism is essential for elucidation of pathological processes. Thus, knowledge of the

2 Healthcare projects are funded by the National Institutes of Health (NIH), Substance Abuse and Mental Health Services (SAMHSA), Health Resources and Services Administration (HRSA), Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDCP), Agency for Healthcare Research and Quality (AHRQ), and Office of Assistant Secretary of Health (OASH).

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Reye’s Syndrome

molecular mechanisms for regulation of the urea cycle, the major pathway of ammonia removal, will prove an understanding of disorders (e.g., Reye's syndrome, hepatitis, cirrhosis and metabolic defects) in which liver function is temporarily or permanently altered. Carbamoyl-phosphate synthetase (CPS), which catalyzes the entry step of the urea cycle, is the primary site of control under many physiological conditions. CPSs vary in subunit structure, nitrogen donor (free ammonia and/or ammonia derived from glutamine), and regulators. However, all CPSs have similar sequences folded into a similar multi-domain structure, and all appear to use a common mechanism to catalyze the form of CP, P/i and 2 ADP from HCO/3, NH/3 and 2 ATP. For glutaminedependent CPSs, subdomain A-2 is a glutaminases; ammonia- specific CPSs retain this region but with replacement of essential residues. Subdomain A-1 mediates interaction between the glutaminase and synthetase moieties. Domain D is the regulatory domain where binding of many allosteric effectors occurs. The two molecules of ATP are utilized at two internally duplicated domains, B and C, with domain D possibly folding to facilitate ATP utilization. The recently reported crystal structure for CPS has shown that domains B and C are structurally equivalent to each other and to the other four members of the N-ligase structural family. We have proposed a novel mechanism for CPS, which couples ATP binding and hydrolysis at domain C to domain B cycling between two alternative conformations. Our first three specific aims are intended to test specific, distinguishing features of the proposed reaction scheme, but will yield significant insights in the structure/function relationship for CPS regardless of the pathway utilized. Proposed specific aims 4 and 5 are intended to elucidate the structural and functional routes of communication among the various domains of CPS that allow its catalysis and regulation. Website: http://crisp.cit.nih.gov/crisp/Crisp_Query.Generate_Screen •

Project Title: CELLULAR PATHOGENESIS OF PEDIATRIC LIVER DISEASE Principal Investigator & Institution: Perlmutter, David H.; Professor; Pediatrics; Washington University Lindell and Skinker Blvd St. Louis, MO 63130 Timing: Fiscal Year 2001; Project Start 01-JUN-2000; Project End 31-MAY-2001 Summary: A number of pediatric liver diseases, such as alpha1-anti-trypsin deficiency, cystic fibrosis, Wilson disease and mitochondrial fatty acid oxidation defects are characterized by abnormalities in protein folding and/or cellular trafficking of trace metals and organic anions may also cause the cholestatic liver diseases associated with overload of copper, iron and bile acids. This program project will examine the hypothesis that the development and severity of liver injury in these diseases is determined in part by the fate of abnormally folded proteins, trace metals or ions as directed by the quality control systems of the cell (chaperons, degradation pathways) and by the host response to their accumulation in specific subcellular compartments (e.g. heat shock, unfolded protein and autophagic responses). In project 1, D. Perlmutter will study alpha1-AT deficiency by using cell lines with inducible expression of mutant alpha1- ATZ to examine its fate in the endoplasmic reticulum (ER) and by establishing transgenic mice with liver-specific inducible expression of alpha1-ATZ to examine the in vivo response to ER retention. In project 2, G. Bu and A.L. Schwartz will examine fundamental mechanisms for quality control within the ER, including studies of a novel ER chaperone system and of the fate of LDL receptor mutants that are retained in the ER. In project 3, A. Strauss will examine the role of mitochondrial trifunctional protein deficiency in the pathogenesis of acute fatty liver of pregnancy and Reye's syndrome. In project 4, J. Gitlin will examine the role of the copper chaperone HAH1 in Wilson disease and other pediatric hepatic copper storage disorders. The core facilities include:

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A) Morphology Core with confocal microscopy and a unique immune electron microscopy serve at the Dept. Cell Biology, University Utrecht, Netherlands; B) Genetically Altered Mouse Core affiliated with the Child Health Research Center at Washington University; and C) Administrative Core. This program will thus provide new information about the pathogenesis of pediatric liver disease through a collaborative multi- disciplinary strategy. Website: http://crisp.cit.nih.gov/crisp/Crisp_Query.Generate_Screen •

Project Title: MITOCHONDRIAL DEHYDROGENASES

SHORT

CHAIN

3-OH-ACYL-COA

Principal Investigator & Institution: Strauss, Arnold W.; Professor and Chair; Pediatrics; Vanderbilt University 3319 West End Ave. Nashville, TN 372036917 Timing: Fiscal Year 2001; Project Start 20-AUG-1999; Project End 30-JUN-2004 Summary: Mitochondrial fatty acid beta-oxidation is the major source of energy in highly oxidative mammalian tissues and is essential for intermediary metabolism and production of ketone bodies in liver. Human genetic defects in fatty acid oxidation genes cause acute liver failure, a Reye's syndrome-like phenotype of hypoketotic, hypoglycemia; cardiomyopathy; skeletal myopathy; or sudden, unexpected childhood death. This pathway consists of four enzymatic steps catalyzed by 12 different nuclearly-encoded enzymes that are developmentally-regulated and tissue- specifically expressed. This proposal focuses on two enzymes catalyzing the third step, the short chain 3-hydroxy-acyl-CoA dehydrogenases (SCHAD). Aims 1 and 2 will examine the hypothesis that tissue-specific and developmental expression of the SCHAD-1 and -2 genes is coordinated with other fatty acid oxidation enzyme genes and involves nuclear hormone receptor transcription factors responsive to energy requirements and nutritional cues. Aim 2 will use the human SCHAD-1 gene and in vitro transfection and transgenic mice to locate critical regulatory sequences. Based upon the SCHAD-1 crystal structure and protein homologies, Aim 3 will determine structure-function relationships of SCHAD-1 of normal and mutant SCHADs after expression in bacteria to explore the hypothesis that SCHAD-1 and long chain 3-hydroxy- acyl-CoA dehydrogenase share common structural domains. Using the human gene sequences we have determined, Aim 4 will delineate SCHAD-1 or -2 mutations in children to examine the proposal that SCHAD deficiency and environmental stresses cause a Reye's syndrome-like phenotype of acute hepatic failure. Aim 5 will examine the effects of the three human SCHAD-1 mutations we have discovered on structure and function, the pathogenetics of SCHAD deficiency, to explore the hypothesis that SCHAD missense mutations result in rapid intramitochondrial degradation secondary to misfolding. Aim 6 is to define the phenotype of SCHAD-1 gene ablation we created in mice as a model of human disease, to examine the effects of environmental and drug (aspirin and acetaminophen) stressors on outcome and to similarly study an SCHAD-2 knockout. These studies will augment understanding of the pathogenesis of fatty acid oxidation disorders causing acute liver failure, cardiomyopathy, and sudden death in children. Website: http://crisp.cit.nih.gov/crisp/Crisp_Query.Generate_Screen

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E-Journals: PubMed Central3 PubMed Central (PMC) is a digital archive of life sciences journal literature developed and managed by the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).4 Access to this growing archive of e-journals is free and unrestricted.5 To search, go to http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Pmc, and type “Reye’s syndrome” (or synonyms) into the search box. This search gives you access to full-text articles. The following is a sample of items found for Reye’s syndrome in the PubMed Central database: •

Murine Adenovirus Infection of SCID Mice Induces Hepatic Lesions that Resemble Human Reye Syndrome. by Pirofski L, Horwitz MS, Scharff MD, Factor SM. 1991 May 15; http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&rendertype=abstr act&artid=51658

The National Library of Medicine: PubMed One of the quickest and most comprehensive ways to find academic studies in both English and other languages is to use PubMed, maintained by the National Library of Medicine.6 The advantage of PubMed over previously mentioned sources is that it covers a greater number of domestic and foreign references. It is also free to use. If the publisher has a Web site that offers full text of its journals, PubMed will provide links to that site, as well as to sites offering other related data. User registration, a subscription fee, or some other type of fee may be required to access the full text of articles in some journals. To generate your own bibliography of studies dealing with Reye’s syndrome, simply go to the PubMed Web site at http://www.ncbi.nlm.nih.gov/pubmed. Type “Reye’s syndrome” (or synonyms) into the search box, and click “Go.” The following is the type of output you can expect from PubMed for “Reye’s syndrome” (hyperlinks lead to article summaries): •

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“Locked-in” state following Reye's syndrome. Author(s): Kotagal S, Rolfe U, Schwarz KB, Escober W. Source: Annals of Neurology. 1984 June; 15(6): 599-601. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6742793&dopt=Abstract

Adapted from the National Library of Medicine: http://www.pubmedcentral.nih.gov/about/intro.html.

With PubMed Central, NCBI is taking the lead in preservation and maintenance of open access to electronic literature, just as NLM has done for decades with printed biomedical literature. PubMed Central aims to become a world-class library of the digital age. 5 The value of PubMed Central, in addition to its role as an archive, lies in the availability of data from diverse sources stored in a common format in a single repository. Many journals already have online publishing operations, and there is a growing tendency to publish material online only, to the exclusion of print. 6 PubMed was developed by the National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM) at the National Institutes of Health (NIH). The PubMed database was developed in conjunction with publishers of biomedical literature as a search tool for accessing literature citations and linking to full-text journal articles at Web sites of participating publishers. Publishers that participate in PubMed supply NLM with their citations electronically prior to or at the time of publication.

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“Reye's syndrome”. Author(s): Budd RA, Hobdell EF. Source: Critical Care Nurse. 1983 March-April; 3(2): 94-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6551218&dopt=Abstract

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“Therapeutic success” in Reye's syndrome. Author(s): Waldman JD, Given GZ, Schwartz AD. Source: The Journal of Pediatrics. 1973 February; 82(2): 343-54. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4684381&dopt=Abstract

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A case of ornithine transcarbamylase deficiency with acute and late onset simulating Reye's syndrome in an adult male. Author(s): Mizoguchi K, Sukehiro K, Ogata M, Onizuka S, Watanabe J, Yoshida I, Yoshino M. Source: Kurume Med J. 1990; 37(2): 105-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2255172&dopt=Abstract

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A comparison of liver ultrastructure in salicylate intoxication and Reye's syndrome. Author(s): Partin JS, Daugherty CC, McAdams AJ, Partin JC, Schubert WK. Source: Hepatology (Baltimore, Md.). 1984 July-August; 4(4): 687-90. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6745858&dopt=Abstract

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A link between Reye's syndrome and aflatoxins? Author(s): Harwig J, Przybylski W, Moodie CA. Source: Can Med Assoc J. 1975 August 23; 113(4): 281. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1148980&dopt=Abstract

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A morphometric study of Reye's syndrome. Correlation of reduced mitochondrial numbers and increased mitochondrial size with clinical manifestations. Author(s): Daugherty CC, Gartside PS, Heubi JE, Saalfeld K, Snyder J. Source: American Journal of Pathology. 1987 November; 129(2): 313-26. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2823614&dopt=Abstract

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A nationwide outbreak of Reye's Syndrome. Its epidemiologic relationship of influenza B. Author(s): Corey L, Rubin RJ, Hattwick MA, Noble GR, Cassidy E. Source: The American Journal of Medicine. 1976 November; 61(5): 615-25. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=984065&dopt=Abstract

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A new patient with dicarboxylic aciduria suggestive of medium-chain Acyl-CoA dehydrogenase deficiency presenting as Reye's syndrome. Author(s): Del Valle JA, Garcia MJ, Merinero B, Perez-Cerda C, Roman F, Jimenez A, Ugarte M, Martinez-Pardo M, Ludena C, Camarero C, et al. Source: Journal of Inherited Metabolic Disease. 1984; 7(2): 62-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6434827&dopt=Abstract

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A possible role for antibodies to tumour necrosis factor alpha and to endotoxin in the treatment of Reye's syndrome. Author(s): Odeh M. Source: Gut. 1995 September; 37(3): 441-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7590445&dopt=Abstract

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A proposed therapy for the encephalopathies of Reye's syndrome and hepatic encephalopathy. Author(s): Anderson B. Source: Medical Hypotheses. 1984 December; 15(4): 415-20. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6098803&dopt=Abstract

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A reemergence of Reye's syndrome. Author(s): Poss WB, Vernon DD, Dean JM. Source: Archives of Pediatrics & Adolescent Medicine. 1994 August; 148(8): 879-82. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8044272&dopt=Abstract

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A Reye's syndrome like illness with early seizures: its relationship to Reye's syndrome. Author(s): Aiyathurai JE. Source: J Singapore Paediatr Soc. 1982; 24(1-2): 33-53. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7183843&dopt=Abstract

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A survey of aspirin use and Reye's syndrome awareness among parents. Author(s): Morris LA, Klimberg R. Source: American Journal of Public Health. 1986 December; 76(12): 1422-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3777289&dopt=Abstract

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Abnormal cellular regulation of lipolysis and phosphorylation in Reye's Syndrome. Author(s): Kang ES, Gates RE, Wrenn EL Jr. Source: Biochem Med. 1982 April; 27(2): 180-94. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7044379&dopt=Abstract

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Abnormal P wave in Reye's syndrome--II. Author(s): Wasserburger RH. Source: The American Journal of Cardiology. 1979 January; 43(1): 166. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=758763&dopt=Abstract

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Abnormal P wave pattern in Reye's syndrome. Author(s): Isner J, Guller B, Scott LP. Source: The American Journal of Cardiology. 1978 February; 41(2): 350-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=623029&dopt=Abstract

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Abnormal pancreatic endocrine function in Reye's syndrome survivors and their relatives: a preliminary report. Author(s): Kang ES, Solomon SS, Duckworth WC, Burghen GA, Schwenzer KS. Source: Pediatric Research. 1979 July; 13(7): 870-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=384352&dopt=Abstract

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Abnormal polyunsaturated fatty acid patterns of serum lipids in Reye's syndrome. Author(s): Ogburn PL Jr, Sharp H, Lloyd-Still JD, Johnson SB, Holman RT. Source: Proceedings of the National Academy of Sciences of the United States of America. 1982 February; 79(3): 908-11. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6950433&dopt=Abstract

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Abnormal regulation of pyridoxal 5'-phosphate in Reye's syndrome. Author(s): Faraj BA, Camp VM, Caplan DB, Ahmann PA, Kutner M. Source: Clinical Chemistry. 1983 October; 29(10): 1832-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6616834&dopt=Abstract

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Abnormalities of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of patients with Reye's syndrome. Author(s): Sinatra F, Yoshida T, Applebaum M, Masion Hoogenraad NJ, Sunshine P. Source: Pediatric Research. 1975 November; 9(11): 829-33. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=171618&dopt=Abstract

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Acetaminophen and Reye's syndrome. Author(s): Little JA. Source: Pediatrics. 1976 December; 58(6): 918. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=995527&dopt=Abstract

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Action stat. Reye's syndrome. Author(s): Doire TL. Source: Nursing. 1999 December; 29(12): 33. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10797692&dopt=Abstract

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Acute aflatoxin B1 toxicity in the macaque and its similarities to Reye's syndrome. Author(s): Bourgeois CH, Shank RC, Grossman RA, Johnsen DO, Wooding WL, Chandavimol P. Source: Laboratory Investigation; a Journal of Technical Methods and Pathology. 1971 March; 24(3): 206-16. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4994463&dopt=Abstract

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Acute encephalopathy in children associated with acute hepatocellular dysfunction. Reye's syndrome revisited. Author(s): Randolph M, Gelfman NA. Source: Am J Dis Child. 1968 September; 116(3): 303-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5676651&dopt=Abstract

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Acute encephalopathy in children in Nagpur: similarity to Reye's syndrome. Author(s): John TJ, Date A, Patoria NK. Source: Indian J Pediatr. 1983 March-April; 50(403): 129-32. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6618571&dopt=Abstract

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Acute encephalopathy with fatty change of viscera (Reye's Syndrome). Author(s): Bornhofen JH, Hankins E, Araoz C. Source: J Ark Med Soc. 1970 July; 67(2): 60-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4246626&dopt=Abstract

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Acute liver failure and encephalopathy (Reye's syndrome?) during salicylate therapy. Author(s): Daum F, Zucker P, Cohen MI. Source: Acta Paediatr Scand. 1976 November; 65(6): 747. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=998231&dopt=Abstract

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Acute liver failure and encephalopathy (Reye's syndrome?) during salicylate therapy. Author(s): Sillanpaa M, Makela AL, Koivikko A. Source: Acta Paediatr Scand. 1975 November; 64(6): 877-80. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1189911&dopt=Abstract

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Acute pancreatitis in Reye's syndrome: a fatal complication during intensive supportive care. Author(s): Chaves-Carballo E, Menezes AH, Bell WE, Hernriquez EM. Source: Southern Medical Journal. 1980 February; 73(2): 152-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7355311&dopt=Abstract

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Acute renal failure in Reye's syndrome. Author(s): Hin SA, Reginald LK, Lim TC. Source: J Singapore Paediatr Soc. 1990; 32(1-2): 36-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2259193&dopt=Abstract

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Acute renal failure in Reye's syndrome. Author(s): Baliga R, Fleischmann LE, Chang CH, Sarnaik AP, Bidani AK, Arcinue EL. Source: Am J Dis Child. 1979 October; 133(10): 1009-13. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=495589&dopt=Abstract

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Adaptive behaviour of Reye's syndrome survivors. Author(s): Weinman B. Source: J Ment Defic Res. 1984 December; 28 ( Pt 4): 297-301. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6527377&dopt=Abstract

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Adult Reye's syndrome after dengue. Author(s): Terry SI, Golden MH, Hanchard B, Bain B. Source: Gut. 1980 May; 21(5): 436-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7429308&dopt=Abstract

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Adult Reye's syndrome. Author(s): Nesbitt JA, Minuk GY. Source: Annals of Emergency Medicine. 1988 February; 17(2): 155-8. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3276249&dopt=Abstract

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Adult Reye's syndrome. Author(s): Al-Tikriti SA, Rowe PA, Munro AJ. Source: Journal of the Royal Society of Medicine. 1984 August; 77(8): 694-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6481745&dopt=Abstract

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Adult Reye's syndrome: a review with new evidence for a generalized defect in intramitochondrial enzyme processing. Author(s): Van Coster RN, De Vivo DC, Blake D, Lombes A, Barrett R, DiMauro S. Source: Neurology. 1991 November; 41(11): 1815-21. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1944914&dopt=Abstract

12 Reye’s Syndrome

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Adult Reye's syndrome: discordance in hepatic subcellular function testing. Author(s): Gill RA, Anderson DC, Almquist AK, Comly WM. Source: Minn Med. 1987 June; 70(6): 347-8, 354. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3600578&dopt=Abstract

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Aetiology of Reye's syndrome. Author(s): Leonard JV. Source: Archives of Disease in Childhood. 1984 January; 59(1): 91. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6696509&dopt=Abstract

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Aetiology of Reye's syndrome. Author(s): Bellman MH, Hall SM. Source: Archives of Disease in Childhood. 1983 September; 58(9): 670-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6625625&dopt=Abstract

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Aflatoxin and Reye's syndrome. Author(s): Stora C, Dvorackova I, Ayraud N. Source: J Med. 1983; 14(1): 47-54. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6411848&dopt=Abstract

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Aflatoxin and Reye's syndrome: a case control study. Author(s): Wray B. Source: Pediatrics. 1981 September; 68(3): 473. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7279490&dopt=Abstract

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Aflatoxin and Reye's syndrome: a case control study. Author(s): Nelson DB, Kimbrough R, Landrigan PS, Hayes AW, Yang GC, Benanides J. Source: Pediatrics. 1980 December; 66(6): 865-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7454477&dopt=Abstract

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Aflatoxin and Reye's syndrome: a study of livers from deceased cases. Author(s): Rogan WJ, Yang GC, Kimbrough RD. Source: Archives of Environmental Health. 1985 March-April; 40(2): 91-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4004347&dopt=Abstract

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Aflatoxin B1 and Reye's syndrome. Author(s): Hogan GR, Ryan NJ, Hayes AW. Source: Lancet. 1978 March 11; 1(8063): 561. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=76107&dopt=Abstract

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Aflatoxin B1; its role in the etiology of Reye's syndrome. Author(s): Ryan NJ, Hogan GR, Hayes AW, Unger PD, Siraj MY. Source: Pediatrics. 1979 July; 64(1): 71-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=450565&dopt=Abstract

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Altered metabolic profiles of valproic acid in a patient with Reye's syndrome. Author(s): Kuhara T, Inoue Y, Matsumoto M, Shinka T, Matsumoto I, Kitamura K, Fujii H, Sakura N. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1985 January 30; 145(2): 135-42. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3918813&dopt=Abstract

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Aminoacid ratios in Reye's syndrome. Author(s): Rittenhouse JW, Mason M, Baublis JV. Source: Lancet. 1979 July 14; 2(8133): 105-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=87959&dopt=Abstract

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An autopsy case of Reye's syndrome associated with acute pancreatitis, acute renal failure and disseminated intravascular coagulopathy. Author(s): Teng RJ, Tsau YK, Chang MH, Lee CY, Chen CL. Source: J Formos Med Assoc. 1990 October; 89(10): 887-91. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1981777&dopt=Abstract

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An outbreak of Reye's syndrome associated with influenza B. Author(s): Reynolds DW, Riley HD Jr, LaFont DS, Vorse H, Stout LC, Carpenter RL. Source: The Journal of Pediatrics. 1972 March; 80(3): 429-32. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5060456&dopt=Abstract

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Anticerebral oedema therapy in Reye's syndrome. Author(s): Lovejoy FH Jr, Bresnan MJ, Lombroso CT, Smith AL. Source: Archives of Disease in Childhood. 1975 December; 50(12): 933-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1220606&dopt=Abstract

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Antipyretics and Reye's syndrome. Author(s): Butterworth RF. Source: Clinical and Investigative Medicine. Medecine Clinique Et Experimentale. 1998 August-October; 21(4-5): 209-10. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9800070&dopt=Abstract

14 Reye’s Syndrome

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Arrhythmias and ischemia-like ECG changes in Reye's syndrome. Author(s): Sarti A, Cecchi F, Manetti A, Busoni P. Source: Intensive Care Medicine. 1996 January; 22(1): 62-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8857440&dopt=Abstract

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ASA and Reye's syndrome: an update. Author(s): Liston AJ. Source: Can Med Assoc J. 1983 October 1; 129(7): 677. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6616371&dopt=Abstract

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Aspirin and Reye's syndrome. Author(s): Khan AS, Kent J, Schonberger LB. Source: Lancet. 1993 April 10; 341(8850): 968. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8096309&dopt=Abstract

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Aspirin and Reye's syndrome. Author(s): Hall SM. Source: Cleve Clin J Med. 1991 July-August; 58(4): 367-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1889120&dopt=Abstract

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Aspirin and Reye's syndrome. Author(s): Roeser HP. Source: Qld Nurse. 1986 September; 5(6): 18. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3099339&dopt=Abstract

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Aspirin and Reye's syndrome. Author(s): Daugherty CC, McAdams AJ, Partin JS. Source: Lancet. 1983 July 9; 2(8341): 104. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6134937&dopt=Abstract

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Aspirin and Reye's syndrome. Author(s): Halpin TJ, Holtzhauer FJ, Campbell RJ, Hall LJ, Correa-Villasenor A, Lanese R, Rice J, Hurwitz ES. Source: Jama : the Journal of the American Medical Association. 1983 June 17; 249(23): 3177. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6854845&dopt=Abstract

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Aspirin and Reye's syndrome. Author(s): Hall SM. Source: Lancet. 1983 March 12; 1(8324): 583-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6131270&dopt=Abstract

Studies 15

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Aspirin and Reye's syndrome. Author(s): Glezen WP. Source: Am J Dis Child. 1982 November; 136(11): 971-2. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7124701&dopt=Abstract

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Aspirin and Reye's syndrome. A reappraisal. Author(s): Glen-Bott AM. Source: Med Toxicol. 1987 May-June; 2(3): 161-5. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3298920&dopt=Abstract

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Aspirin and Reye's syndrome. How strong an association? Author(s): Orlowski JP. Source: Postgraduate Medicine. 1984 May; 75(6): 47-54. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6718283&dopt=Abstract

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Aspirin and Reye's syndrome: discovery of aspirin and paracetamol. Author(s): Aronoff DM. Source: Drug Safety : an International Journal of Medical Toxicology and Drug Experience. 2002; 25(10): 751. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12167070&dopt=Abstract

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Aspirin and Reye's syndrome: is the response appropriate? Author(s): Langford NJ. Source: Journal of Clinical Pharmacy and Therapeutics. 2002 June; 27(3): 157-60. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12081628&dopt=Abstract

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Aspirin and Reye's syndrome: the change in prescribing habits of health professionals. Author(s): Rahwan GL, Rahwan RG. Source: Drug Intell Clin Pharm. 1986 February; 20(2): 143-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3948691&dopt=Abstract

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Aspirin and Reye's syndrome--do parents know? Author(s): Hall RW. Source: J R Coll Gen Pract. 1987 October; 37(303): 459-60. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3505289&dopt=Abstract

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Aspirin anticoagulation for mechanical heart valves and Reye's syndrome. Author(s): Jacklitsch M, Leyland S. Source: The Journal of Thoracic and Cardiovascular Surgery. 1988 January; 95(1): 146-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3336232&dopt=Abstract

16 Reye’s Syndrome

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Aspirin as a risk factor in Reye's syndrome. Author(s): Waldman RJ, Hall WN, McGee H, Van Amburg G. Source: Jama : the Journal of the American Medical Association. 1982 June 11; 247(22): 3089-94. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7077803&dopt=Abstract

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Aspirin consumption and severity of Reye's syndrome. Author(s): Brown RD, Wilson JT. Source: Pediatrics. 1983 February; 71(2): 293-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6823439&dopt=Abstract

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Aspirin esterase activity and Reye's syndrome. Author(s): Tomasova H, Nevoral J, Pachl J, Kincl V. Source: Lancet. 1984 July 7; 2(8393): 43. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6145962&dopt=Abstract

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Association between salicylates and Reye's syndrome. Author(s): Soller RW, Stander H. Source: Jama : the Journal of the American Medical Association. 1983 February 18; 249(7): 883-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6823038&dopt=Abstract

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Association of Reye's syndrome with viral infection. Author(s): Linnemann CC Jr, Shea L, Kauffman CA, Schiff GM, Partin JC, Schubert WK. Source: Lancet. 1974 July 27; 2(7874): 179-82. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4135606&dopt=Abstract

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Augmented tumour necrosis factor in Reye's syndrome associated with dengue virus. Author(s): Iyngkaran N, Yadav M, Harun F, Kamath KR. Source: Lancet. 1992 December 12; 340(8833): 1466-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1360578&dopt=Abstract

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Battered child syndrome in a four year old with previous diagnosis of Reye's syndrome. Author(s): Conradi S, Brissie R. Source: Forensic Science International. 1986 February-March; 30(2-3): 195-203. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3957191&dopt=Abstract

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Behavior management of aggressive sequela after Reye's syndrome. Author(s): Jacobs HE, Lynch M, Cornick J, Slifer K. Source: Archives of Physical Medicine and Rehabilitation. 1986 August; 67(8): 558-63. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2874781&dopt=Abstract

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beta-Hydroxy-beta-methyglutaricaciduria presenting as Reye's syndrome. Author(s): Leonard JV, Seakins JW, Griffin NK. Source: Lancet. 1979 March 24; 1(8117): 680. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=85928&dopt=Abstract

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beta-hydroxy-beta-methylglutaricaciduria, Reye's syndrome, and Echovirus 11. Author(s): Leonard JV, Seakins JW, Griffin NK, Marshall WC. Source: Lancet. 1979 May 26; 1(8126): 1147. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=86872&dopt=Abstract

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Beware of Reye's syndrome. Author(s): Reeves KR. Source: The American Journal of Nursing. 1974 September; 74(9): 1621-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4496439&dopt=Abstract

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Biochemical abnormalities in Reye's syndrome. Author(s): Alvira MM, Forman DT. Source: Ann Clin Lab Sci. 1974 November-December; 4(6): 477-83. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4154722&dopt=Abstract

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Biochemical correlates of illness and recovery in Reye's syndrome. Author(s): Trauner D, Sweetman L, Holm J, Kulovich S, Nyhan WL. Source: Annals of Neurology. 1977 September; 2(3): 238-41. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=617569&dopt=Abstract

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Brain lesions in Reye's syndrome. Author(s): Evans H, Bourgeois CH, Comer DS, Keschamras N. Source: Arch Pathol. 1970 December; 90(6): 543-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5485110&dopt=Abstract

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Brain stem auditory evoked potentials in a case of Reye's syndrome. Author(s): DiLiberti JH, Laxer KD. Source: Clinical Pediatrics. 1984 April; 23(4): 238-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6697634&dopt=Abstract

18 Reye’s Syndrome

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Brain ultrastructure in Reye's syndrome. Author(s): Partin JC, Partin JS, Schubert WK, McLaurin RL. Source: Journal of Neuropathology and Experimental Neurology. 1975 September; 34(5): 425-44. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1176996&dopt=Abstract

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Carnitine deficiency, organic acidemias, and Reye's syndrome. Author(s): Stumpf DA, Parker WD Jr, Angelini C. Source: Neurology. 1985 July; 35(7): 1041-5. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3892364&dopt=Abstract

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Carnitine metabolism and urinary organic acid excretion in Reye's syndrome and salicylate intoxication. Author(s): Takayanagi M, Kakinuma H, Yamamoto S, Nakajima H. Source: Acta Paediatr Jpn. 1990 August; 32(4): 406-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2288223&dopt=Abstract

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Case of fulminant Reye's syndrome. Author(s): Redel C, Shulman RJ. Source: Pediatric Emergency Care. 1992 February; 8(1): 62-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1520389&dopt=Abstract

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Cellular regulation of lipolysis in Reye's syndrome. Author(s): Aiyathurai EJ, Boon WH. Source: Biochem Med. 1983 June; 29(3): 398-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6351855&dopt=Abstract

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Central retinal vein occlusion in Reye's syndrome. Author(s): Smith P, Green WR, Miller NR, Terry JM. Source: Archives of Ophthalmology. 1980 July; 98(7): 1256-60. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6156667&dopt=Abstract

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Cerebral MRS in infant with suspected Reye's syndrome. Author(s): Ernst T, Ross BD, Flores R. Source: Lancet. 1992 August 22; 340(8817): 486. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1354813&dopt=Abstract

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Cerebrospinal fluid glutamine in Reye's syndrome. Author(s): Sunakorn P. Source: Southeast Asian J Trop Med Public Health. 1975 December; 6(4): 606-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1226544&dopt=Abstract

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Changing trends of inborn errors in Reye's syndrome: rarity is relative. Author(s): Hsia YE. Source: Hepatology (Baltimore, Md.). 1990 February; 11(2): 327-8. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2407633&dopt=Abstract

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Choline salicylates and Reye's syndrome. Author(s): Sarll DW, Duxbury AJ. Source: British Dental Journal. 1986 November 8; 161(9): 317-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3490870&dopt=Abstract

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Chronic camphor ingestion mimicking Reye's syndrome. Author(s): Jimenez JF, Brown AL, Arnold WC, Byrne WJ. Source: Gastroenterology. 1983 February; 84(2): 394-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6848413&dopt=Abstract

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Citrulline in Reye's syndrome. Author(s): Thisyakorn U, Sunakorn P. Source: J Med Assoc Thai. 1980 April; 63(4): 196-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7381355&dopt=Abstract

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Clinical features and prognosis of Reye's syndrome. Author(s): Aiyathurai JE, Wong HB. Source: Archives of Disease in Childhood. 1984 November; 59(11): 1110-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6508351&dopt=Abstract

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Clinical features and prognosis of Reye's syndrome. Author(s): Glasgow JF. Source: Archives of Disease in Childhood. 1984 March; 59(3): 230-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6712271&dopt=Abstract

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Clinicopathologic features of the heart in Reye's syndrome. Author(s): Brown RE, Madge GE. Source: The American Journal of Cardiology. 1972 February; 29(2): 303-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5058355&dopt=Abstract

20 Reye’s Syndrome

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Co-existence of hepatitis A and adult Reye's syndrome. Author(s): Duerksen DR, Jewell LD, Mason AL, Bain VG. Source: Gut. 1997 July; 41(1): 121-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9274483&dopt=Abstract

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Commentary: Reye's syndrome. Author(s): Keating JP. Source: The Journal of Pediatrics. 1977 April; 90(4): 641. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=839386&dopt=Abstract

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Comparison of cytosolic and mitochondrial hepatic enzyme alterations in Reye's syndrome. Author(s): Mitchell RA, Ram ML, Arcinue EL, Chang CH. Source: Pediatric Research. 1980 November; 14(11): 1216-21. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7454435&dopt=Abstract

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Computerized evaluation of electroencephalographic changes accompanying exchange transfusion in Reye's syndrome. Author(s): Barr RE, Ackmann JJ, Harrington GJ, Varma RR, Lewis JD, Casper JT. Source: Electroencephalography and Clinical Neurophysiology. 1977 April; 42(4): 46679. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=66130&dopt=Abstract

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Computerized tomography in Reye's syndrome: evidence for pathological cerebral vasodilatation. Author(s): Giannotta SL, Hopkins J, Kindt GW. Source: Neurosurgery. 1978 May-June; 2(3): 201-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=732969&dopt=Abstract

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Confirmation of serum salicylate levels in Reye's syndrome: a comparison between the Natelson colorimetric method and high performance liquid chromatography. Author(s): Clark JH, Nagamori K, Fitzgerald JF. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1985 February 15; 145(3): 243-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3987027&dopt=Abstract

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Continuous monitoring of intracranial pressure in Reye's syndrome--5 years experience. Author(s): Chi CS, Law KL, Wong TT, Su GY, Lin N. Source: Acta Paediatr Jpn. 1990 August; 32(4): 426-34. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2288226&dopt=Abstract

Studies 21

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Creatine kinase isoenzymes in serum of patients with Reye's syndrome. Author(s): Rock RC, Dreskin R, Kickler T, Wimsatt T. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1975 July 9; 62(1): 159-62. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1149273&dopt=Abstract

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Critical care and anesthetic management of Reye's syndrome. Author(s): Hubbert CH. Source: Southern Medical Journal. 1979 June; 72(6): 684-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=451652&dopt=Abstract

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Current concepts in Reye's syndrome. Author(s): Glasgow JF, Moore R. Source: Br J Hosp Med. 1993 November 17-December 14; 50(10): 599-604. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8293241&dopt=Abstract

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Current treatment of Reye's syndrome. Author(s): Hofschire PJ, Pinsky WW, Cheatham JP, Kugler JD, Vanderhoof JA, Antonson DL, Torkelson RD, Hellbusch LC, Miller D. Source: Nebr Med J. 1982 August; 67(8): 219-22. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7133215&dopt=Abstract

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Cyclic nucleotide phosphodiesterase activities of the human liver: comparison between control and Reye's syndrome samples. Author(s): Kang ES. Source: Pediatric Research. 1978 July; 12(7): 761-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=211480&dopt=Abstract

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Cyclic nucleotide phosphodiesterase activity of human liver: is there an altered form in Reye's syndrome? Author(s): Mitchell RA. Source: Pediatric Research. 1979 August; 13(8): 945-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=225720&dopt=Abstract

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Dangers of mannitol in treatment of Reye's syndrome. Author(s): Schmidley J, Sander J, Diamond I, Fishman RA. Source: The New England Journal of Medicine. 1979 July 12; 301(2): 106-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=449934&dopt=Abstract

22 Reye’s Syndrome

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Decompressive craniectomy for the encephalopathy of Reye's syndrome. Author(s): Ausman JI, Rogers C, Sharp HL. Source: Surgical Neurology. 1976 August; 6(2): 97-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=951659&dopt=Abstract

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Deficient activity of hepatic pyruvate dehydrogenase and pyruvate carboxylase in Reye's syndrome. Author(s): Robinson BH, Gall DG, Cutz E. Source: Pediatric Research. 1977 April; 11(4): 279-81. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=191789&dopt=Abstract

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Dermatoglyphics and Reye's syndrome. Author(s): Abraham JL. Source: Lancet. 1971 May 8; 1(7706): 969-70. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4102295&dopt=Abstract

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Development of Reye's syndrome protocol in the Hamilton health region. Author(s): Hurley RM. Source: Can Med Assoc J. 1980 June 21; 122(12): 1351, 1354. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7260740&dopt=Abstract

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Diagnosis and management of Reye's syndrome. Author(s): Sarnaik AP. Source: Compr Ther. 1982 October; 8(10): 47-53. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6814814&dopt=Abstract

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Diagnostic criteria for influenza B-associated Reye's syndrome: clinical vs. pathologic criteria. Author(s): Corey L, Rubin RJ, Bregman D, Gregg MB. Source: Pediatrics. 1977 November; 60(5): 702-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=917632&dopt=Abstract

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Diagnostic quality of laboratory tests as evaluated by graphic comparison of “first test” data, with Reye's syndrome “workup” assays as a model. Author(s): Meites S, Bubis S. Source: Clinical Chemistry. 1987 January; 33(1): 100-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3802454&dopt=Abstract

Studies 23

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Differential diagnosis of Reye's syndrome. Author(s): Allison F, Bennett MJ. Source: Developmental Medicine and Child Neurology. 1987 December; 29(6): 830. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3691984&dopt=Abstract

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Differential diagnosis of Reye's syndrome. Author(s): Robinson RO. Source: Developmental Medicine and Child Neurology. 1987 February; 29(1): 110-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3556790&dopt=Abstract

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Disorders of mitochondrial beta-oxidation: prenatal and early postnatal diagnosis and their relevance to Reye's syndrome and sudden infant death. Author(s): Pollitt RJ. Source: Journal of Inherited Metabolic Disease. 1989; 12 Suppl 1: 215-30. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2509809&dopt=Abstract

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Displacement of hepatic ornithine carbamoyltransferase from mitochondria to cytosol in Reye's syndrome. Author(s): Woodfin BM, Davis LE. Source: Biochemical Medicine and Metabolic Biology. 1991 October; 46(2): 255-62. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1782015&dopt=Abstract

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Drug therapy for Reye's syndrome. Author(s): Mutchie KD, Burckart GJ. Source: Am J Hosp Pharm. 1979 June; 36(6): 767-73. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=463892&dopt=Abstract

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Early diagnosis as a curb to Reye's syndrome mortality. Author(s): Evers JC, Davoli E. Source: Va Med. 1982 May; 109(5): 319-22. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7102085&dopt=Abstract

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Editorial: Ammonia disposal in Reye's syndrome. Author(s): Smith AL. Source: The New England Journal of Medicine. 1976 April 15; 294(16): 897-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1250317&dopt=Abstract

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Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria. Author(s): Tonsgard JH, Getz GS. Source: The Journal of Clinical Investigation. 1985 August; 76(2): 816-25. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4031073&dopt=Abstract

24 Reye’s Syndrome

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Effect of Reye's syndrome serum on the ultrastructure of isolated liver mitochondria. Author(s): Tonsgard JH. Source: Laboratory Investigation; a Journal of Technical Methods and Pathology. 1989 April; 60(4): 568-73. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2496274&dopt=Abstract

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Effects of antipyretics on mortality due to influenza B virus in a mouse model of Reye's syndrome. Author(s): Crocker JF, Digout SC, Lee SH, Rozee KR, Renton K, Field CA, Acott P, Murphy MG. Source: Clinical and Investigative Medicine. Medecine Clinique Et Experimentale. 1998 August-October; 21(4-5): 192-202. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9800068&dopt=Abstract

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Effects of peroxidized polyunsaturated fatty acids on mitochondrial function and structure: pathogenetic implications for Reye's syndrome. Author(s): Brown RE, Bhuvaneswaran C, Brewster M. Source: Ann Clin Lab Sci. 1988 July-August; 18(4): 337-43. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2900617&dopt=Abstract

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Effects of professional and media warnings about the association between aspirin use in children and Reye's syndrome. Author(s): Soumerai SB, Ross-Degnan D, Kahn JS. Source: The Milbank Quarterly. 1992; 70(1): 155-82. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1316991&dopt=Abstract

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Elevated serum gamma-aminobutyric acid levels in children with Reye's syndrome. Author(s): Minuk GY, Sarjeant EJ, Buchan K. Source: Journal of Pediatric Gastroenterology and Nutrition. 1985 August; 4(4): 528-31. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4032163&dopt=Abstract

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Encephalopathy and fatty degeneration of the viscera (Reye's syndrome): a clinicopathologic entity? Author(s): Burns RR, Silverberg SG. Source: Southern Medical Journal. 1970 February; 63(2): 183-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5411929&dopt=Abstract

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Encephalopathy and fatty degeneration of the viscera (Reye's syndrome): report of a case and brief review of the literature. Author(s): Tinaztepe K, Baykara E, Yalaz K. Source: Turk J Pediatr. 1969 July; 11(3): 132-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5371155&dopt=Abstract

Studies 25

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Encephalopathy and fatty degeneration of the viscera. Reye's syndrome. Author(s): Mack RF. Source: Minn Med. 1968 March; 51(3): 335-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5649328&dopt=Abstract

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Encephalopathy and fatty degeneration of the viscera: Reye's syndrome. Author(s): Hartford J. Source: Nebr Med J. 1973 August; 58(8): 312-3. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4726381&dopt=Abstract

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Encephalopathy and fatty degeneration of viscera: Reye's syndrome. Author(s): Mowat AP. Source: Archives of Disease in Childhood. 1973 June; 48(6): 411-3. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4197287&dopt=Abstract

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Encephalopathy and fatty liver (Reye's syndrome). Author(s): Schubert WK, Partin JC, Partin JS. Source: Prog Liver Dis. 1972; 4: 489-510. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4569008&dopt=Abstract

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Encephalopathy of Reye's syndrome: a review of pathogenetic hypotheses. Author(s): DeLong GR, Glick TH. Source: Pediatrics. 1982 January; 69(1): 53-63. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7033913&dopt=Abstract

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Enzymatic alterations in Reye's syndrome: prognostic implications. Author(s): Roe CR, Schonberger LB, Gelbach SH, Wies LA, Sidbury JB Jr. Source: Pediatrics. 1975 January; 55(1): 119-26. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1110856&dopt=Abstract

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Epidemiologic studies of Reye's syndrome: cases seen in Pittsburgh, October 1973April 1975. Author(s): Ruben FL, Streiff EJ, Neal M, Michaels RH. Source: American Journal of Public Health. 1976 November; 66(11): 1096-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=984281&dopt=Abstract

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Epidemiology of Reye's syndrome, United States, 1991-1994: comparison of CDC surveillance and hospital admission data. Author(s): Sullivan KM, Belay ED, Durbin RE, Foster DA, Nordenberg DF. Source: Neuroepidemiology. 2000 November-December; 19(6): 338-44. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11060509&dopt=Abstract

26 Reye’s Syndrome

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Erythrocyte lipid abnormalities in Reye's syndrome. Author(s): Schwarz KB, Larroya S, Kohlman L, Morrison A. Source: Pediatric Research. 1987 April; 21(4): 352-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3574986&dopt=Abstract

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Evaluation of level of consciousness by the Glasgow coma scale in children with Reye's syndrome. Author(s): Duncan CC, Ment LR, Shaywitz BA. Source: Neurosurgery. 1983 December; 13(6): 650-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6657017&dopt=Abstract

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Evidence for hypertyraminemia in Reye's syndrome. Author(s): Faraj BA, Newman SL, Caplan DB, Ali FM, Camp VM, Ahmann PA. Source: Pediatrics. 1979 July; 64(1): 76-80. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=450566&dopt=Abstract

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Exchange transfusion for Reye's syndrome. Author(s): Lewis JD, Varma RR, Harrington G, Casper J, Ackmann JJ, Darin JC. Source: The Journal of Surgical Research. 1975 March; 18(3): 327-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1134093&dopt=Abstract

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Facilitation of exchange transfusions with Scribner shunts in Reye's syndrome. Author(s): Strauss RA, Kling TF, Levinsohn MW, Danielson RA. Source: American Journal of Surgery. 1976 June; 131(6): 772-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=937661&dopt=Abstract

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Falling incidence of Reye's syndrome in Northern Ireland. Author(s): Robinson PH, Glasgow JF, Moore R. Source: Lancet. 1988 August 20; 2(8608): 446. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2900367&dopt=Abstract

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Fatal varicella or Reye's syndrome: an unusual cause of death in a renal graft recipient. Author(s): Le Guen E, Deminiere C, Larue JR, Postec E, Morel D, Aparicio M, Potaux L. Source: Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 1992; 7(2): 158-60. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1314977&dopt=Abstract

Studies 27

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Fatty acid composition of hepatic triglycerides in Reye's syndrome: implications for hepatic desaturase abnormalities. Author(s): Kang ES, Johnson SB, Holman RT. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1991 December 31; 204(1-3): 167-77. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1819459&dopt=Abstract

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Fatty acids and metabolic disturbances in Reye's syndrome. Author(s): Brown RE, Madge GE. Source: Arch Pathol. 1972 November; 94(5): 475-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5079858&dopt=Abstract

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Fatty acids and mitochondrial injury in Reye's syndrome. Author(s): Brown RE, Madge GE. Source: The New England Journal of Medicine. 1972 April 6; 286(14): 787-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5025795&dopt=Abstract

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Fatty acids and Reye's syndrome. Author(s): Mock DM. Source: Hepatology (Baltimore, Md.). 1986 November-December; 6(6): 1414-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3793015&dopt=Abstract

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Fatty liver in sudden childhood death. Implications for Reye's syndrome? Author(s): Bonnell HJ, Beckwith JB. Source: Am J Dis Child. 1986 January; 140(1): 30-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3942104&dopt=Abstract

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Free fatty acids in an animal model of Reye's syndrome. Author(s): Deshmukh DR, Deshmukh GD, Shope TC, Radin NS. Source: Biochimica Et Biophysica Acta. 1983 September 20; 753(2): 153-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6615853&dopt=Abstract

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From the National Institute of Allergy and Infectious Diseases: Summary of a workshop on disease mechanisms and prospects for prevention of Reye's syndrome. Author(s): La Montagne JR. Source: The Journal of Infectious Diseases. 1983 November; 148(5): 943-50. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6631079&dopt=Abstract

28 Reye’s Syndrome

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From the National Institute of Allergy and Infectious Diseases: summary of a workshop on influenza B viruses and Reye's syndrome. Author(s): LaMontagne JR. Source: The Journal of Infectious Diseases. 1980 September; 142(3): 452-65. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7441013&dopt=Abstract

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Generation of allantoin from the oxidation of urate by cytochrome c and its possible role in Reye's syndrome. Author(s): Martens ME, Storey BT, Lee CP. Source: Archives of Biochemistry and Biophysics. 1987 January; 252(1): 91-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3028263&dopt=Abstract

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Glutamate dehydrogenase in Reye's syndrome. Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP. Author(s): Holt JT, Arvan DA, Mayer T, Smith TJ, Bell JE. Source: Biochimica Et Biophysica Acta. 1983 November 28; 749(1): 42-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6639955&dopt=Abstract

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Glycogen complexes in muscle in Reye's syndrome simulating virus-like particles. Author(s): Collins DN, Gilbert EF. Source: Laboratory Investigation; a Journal of Technical Methods and Pathology. 1977 January; 36(1): 91-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=830997&dopt=Abstract

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Grade I Reye's syndrome. A frequent cause of vomiting and liver dysfunction after varicella and upper-respiratory-tract infection. Author(s): Lichtenstein PK, Heubi JE, Daugherty CC, Farrell MK, Sokol RJ, Rothbaum RJ, Suchy FJ, Balistreri WF. Source: The New England Journal of Medicine. 1983 July 21; 309(3): 133-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6866012&dopt=Abstract

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Grade I Reye's syndrome--outcome and predictors of progression to deeper coma grades. Author(s): Heubi JE, Daugherty CC, Partin JS, Partin JC, Schubert WK. Source: The New England Journal of Medicine. 1984 December 13; 311(24): 1539-42. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6504082&dopt=Abstract

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Hepatic and cerebral pathology findings in children with fatal salicylate intoxication: further evidence for a causal relation between salicylate and Reye's syndrome. Author(s): Starko KM, Mullick FG. Source: Lancet. 1983 February 12; 1(8320): 326-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6185805&dopt=Abstract

Studies 29

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Hepatic and encephalopathic components of Reye's syndrome: factor analysis of admission data from 209 patients. Author(s): Mitchell RA, Partin JC, Partin JS, Ram ML. Source: Neurology. 1985 August; 35(8): 1236-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4022364&dopt=Abstract

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Hepatic degeneration and dysfunction in Reye's syndrome. Author(s): Brown RE, Madge GE. Source: Am J Dig Dis. 1971 December; 16(12): 1116-22. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4332646&dopt=Abstract

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Hepatic encephalopathy and Reye's syndrome. Author(s): Partin JC. Source: Pediatric Annals. 1977 May; 6(5): 346-54. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=854374&dopt=Abstract

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Hepatic lipid in Reye's syndrome: histochemical and ultrastructural characteristics. Author(s): Johnson FB, Mullick FG, Brown RE. Source: Pa Med. 1974 June; 77(6): 39-41. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4134824&dopt=Abstract

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Hepatic metabolic alterations in rats treated with low-dose endotoxin and aspirin: an animal model of Reye's syndrome. Author(s): Kilpatrick LE, Polin RA, Douglas SD, Corkey BE. Source: Metabolism: Clinical and Experimental. 1989 January; 38(1): 73-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2909830&dopt=Abstract

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Hepatic polyamine metabolism in children with Reye's syndrome. Author(s): Mukhopadhyay A, Deshmukh DR, Sarnaik AP. Source: Enzyme. 1991; 45(4): 209-14. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1823865&dopt=Abstract

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Hepatic ultrastructure in Reye's syndrome. Author(s): Brown RE, Madge GE. Source: Va Med Mon (1918). 1972 December; 99(12): 1295-300. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4654979&dopt=Abstract

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How common is Reye's syndrome? Author(s): DeVivo DC. Source: The New England Journal of Medicine. 1983 July 21; 309(3): 179-81. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6866017&dopt=Abstract

30 Reye’s Syndrome

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Human ornithine transcarbamylase. Purification and characterization of the enzyme from normal liver and the liver of a Reye's syndrome patient. Author(s): Pierson DL, Cox SL, Gilbert BE. Source: The Journal of Biological Chemistry. 1977 September 25; 252(18): 6464-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=893420&dopt=Abstract

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Hyperammonemia and Reye's syndrome. Author(s): Kang ES, Gerald PS. Source: The New England Journal of Medicine. 1972 June 1; 286(22): 1216-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5021339&dopt=Abstract

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Hypercatecholaminemia in Reye's syndrome. Author(s): Faraj BA, Caplan DB, Newman SL, Ahmann PA, Camp VM, Kutner M. Source: Pediatrics. 1984 April; 73(4): 481-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6709427&dopt=Abstract

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Hypophosphatemia and Reye's syndrome. Author(s): Carroll JL, Kanter RK. Source: Critical Care Medicine. 1985 June; 13(6): 480-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3996000&dopt=Abstract

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Hypothermia: an unusual manifestation of Reye's syndrome. Author(s): Taly AB, Crunda JP, Nagaraja D, Ravindra JB. Source: Indian Journal of Medical Sciences. 1990 September; 44(9): 237-8, 243. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2269514&dopt=Abstract

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Identification of fatty acid methyl esters in kidneys and livers of two patients with Reye's syndrome. Author(s): Sudo M, Tanioka KI, Momoi T, Akaishi K, Suzuki Y. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1978 March 1; 84(1-2): 179-84. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=639302&dopt=Abstract

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Identification of long chain dicarboxylic acids in the serum of two patients with Reye's syndrome. Author(s): Ng KJ, Andresen BD, Hilty MD, Bianchine JR. Source: Journal of Chromatography. 1983 August 12; 276(1): 1-10. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6672002&dopt=Abstract

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Identification of the Reye's syndrome “serum factor”. Author(s): Aprille JR, Austin J, Costello CE, Royal N. Source: Biochemical and Biophysical Research Communications. 1980 May 14; 94(1): 381-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7387701&dopt=Abstract

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Immunopharmacological considerations in Reye's syndrome: a possible xenobiotic initiated disorder? Author(s): Mullen PW. Source: Biochemical Pharmacology. 1978 January 15; 27(2): 145-9. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=341895&dopt=Abstract

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Impaired oxidative metabolism of salicylate in Reye's syndrome. Author(s): Meert KL, Kauffman RE, Deshmukh DR, Sarnaik AP. Source: Dev Pharmacol Ther. 1990; 15(2): 57-60. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2078973&dopt=Abstract

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Important role of prodromal viral infections responsible for inhibition of xenobiotic metabolizing enzymes in the pathomechanism of idiopathic Reye's syndrome, Stevens-Johnson syndrome, autoimmune hepatitis, and hepatotoxicity of the therapeutic doses of acetaminophen used in genetically predisposed persons. Author(s): Prandota J. Source: American Journal of Therapeutics. 2002 March-April; 9(2): 149-56. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11897929&dopt=Abstract

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Improved assay for spinal fluid glutamine, and values for children with Reye's syndrome. Author(s): Glasgow AM, Dhiensiri K. Source: Clinical Chemistry. 1974 June; 20(6): 642-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4830166&dopt=Abstract

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In vivo proton magnetic resonance spectroscopy in a case of Reye's syndrome. Author(s): Kreis R, Pfenninger J, Herschkowitz N, Boesch C. Source: Intensive Care Medicine. 1995 March; 21(3): 266-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7790619&dopt=Abstract

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Inborn errors of metabolism (IEM) revealed by Reye's syndrome (RS) Author(s): Fayon M, Carre M, Parrot-Roulaud F, Galperine RI, Sarlangue J, Lamireau T, Demarquez JL. Source: Intensive Care Medicine. 1992; 18(7): 443. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1469188&dopt=Abstract

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Inborn errors of metabolism in children referred with Reye's syndrome. A changing pattern. Author(s): Rowe PC, Valle D, Brusilow SW. Source: Jama : the Journal of the American Medical Association. 1988 December 2; 260(21): 3167-70. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3184395&dopt=Abstract

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Incidence of Reye's syndrome in France: a hospital-based survey. Author(s): Autret-Leca E, Jonville-Bera AP, Llau ME, Bavoux F, Saudubray JM, Laugier J, Devictor D, Barbier P; French Departments of Paediatrics. Source: Journal of Clinical Epidemiology. 2001 August; 54(8): 857-62. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11470397&dopt=Abstract

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Infectious mononucleosis and Reye's syndrome. Author(s): Dorman JM. Source: Jama : the Journal of the American Medical Association. 1980 April 25; 243(16): 1631. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7359749&dopt=Abstract

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Infectious mononucleosis and Reye's syndrome: a fatal case with studies for EpsteinBarr virus. Author(s): Rahal JJ Jr, Henle G. Source: Pediatrics. 1970 November; 46(5): 776-80. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5481078&dopt=Abstract

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Influenza A virus and Reye's syndrome in adults. Author(s): Davis LE, Kornfeld M. Source: Journal of Neurology, Neurosurgery, and Psychiatry. 1980 June; 43(6): 516-21. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7205293&dopt=Abstract

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Influenza B-associated Reye's syndrome: incidence in Michigan and potential for prevention. Author(s): Corey L, Rubin RJ, Thompson TR, Noble GR, Cassidy E, Hattwick MA, Gregg MB, Eddins D. Source: The Journal of Infectious Diseases. 1977 March; 135(3): 398-407. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=850077&dopt=Abstract

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Initial and follow-up MRI in a case of early diagnosed Reye's syndrome. Author(s): Ozdoba C, Pfenninger J, Schroth G. Source: Neuroradiology. 1997 July; 39(7): 495-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9258926&dopt=Abstract

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Inner ear degeneration in Reye's syndrome. Author(s): Hinojosa R, Lindsay JR. Source: Arch Otolaryngol. 1977 November; 103(11): 634-40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=303511&dopt=Abstract

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Inner ear pathology associated with Reye's syndrome. Author(s): Rarey KE, Davis JA, Davis LE, Hawkins JE Jr. Source: International Journal of Pediatric Otorhinolaryngology. 1983 December; 6(3): 255-63. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6144641&dopt=Abstract

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Intellectual and emotional sequelae of Reye's Syndrome. Author(s): Benjamin PY, Levinsohn M, Drotar D, Hanson EE. Source: Critical Care Medicine. 1982 September; 10(9): 583-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7105767&dopt=Abstract

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Intracranial hypertension: a Reye's syndrome complication. Author(s): Feaster S. Source: Dimensions of Critical Care Nursing : Dccn. 1984 January-February; 3(1): 24-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6559668&dopt=Abstract

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Intracranial pressure monitoring in Reye's syndrome. Author(s): Pizzi FJ, Schut L, Berman W, Holzhapple W. Source: Childs Brain. 1976; 2(1): 59-66. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1277955&dopt=Abstract

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Intracranial pressure monitoring in Reye's syndrome. Author(s): Haller J. Source: Hosp Pract. 1980 February; 15(2): 101-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6773873&dopt=Abstract

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Intravenous calcium treatment of refractory hypotension in Reye's syndrome. Author(s): Jones R, Thompson JA. Source: Archives of Neurology. 1984 July; 41(7): 786-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6743072&dopt=Abstract

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Investigation of an epidemic of Reye's syndrome in northern region of India. Author(s): Benakappa DG, Vanitha J. Source: Indian Pediatrics. 2000 March; 37(3): 342-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10750088&dopt=Abstract

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Investigation of an epidemic of Reye's syndrome in northern region of India. Author(s): Ghosh D, Dhadwal D, Aggarwal A, Mitra S, Garg SK, Kumar R, Kaur B. Source: Indian Pediatrics. 1999 November; 36(11): 1097-106. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10745330&dopt=Abstract

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Investigation of metabolic disorders resembling Reye's syndrome. Author(s): Green A, Hall SM. Source: Archives of Disease in Childhood. 1992 October; 67(10): 1313-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1444539&dopt=Abstract

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Is a compromised interferon response an etiologic factor in Reye's syndrome? Author(s): Rozee KR, Lee SH, Crocker JF, Digout S, Arcinue E. Source: Can Med Assoc J. 1982 April 1; 126(7): 798-802. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6176306&dopt=Abstract

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Is aspirin a cause of Reye's syndrome? A case against. Author(s): Orlowski JP, Hanhan UA, Fiallos MR. Source: Drug Safety : an International Journal of Medical Toxicology and Drug Experience. 2002; 25(4): 225-31. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11994026&dopt=Abstract

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Is fatty liver and kidney disease in chickens a suitable model for Reye's syndrome? Author(s): Awrich P, Wolf B. Source: Lancet. 1983 February 5; 1(8319): 306. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6130325&dopt=Abstract

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Is Reye's syndrome a disorder of the locus ceruleus? Author(s): Maurizi CP. Source: Medical Hypotheses. 1985 April; 16(4): 355-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4010574&dopt=Abstract

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Is Reye's syndrome caused by augmented release of tumour necrosis factor? Author(s): Larrick JW, Kunkel SL. Source: Lancet. 1986 July 19; 2(8499): 132-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2873400&dopt=Abstract

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Isolation of influenza A virus in Reye's syndrome. Author(s): Visudhiphan P, Chatiyanonda K. Source: Southeast Asian J Trop Med Public Health. 1975 June; 6(2): 260-3. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1166354&dopt=Abstract

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Isolation of influenza virus from liver and muscle biopsy specimens from a surviving case of Reye's syndrome. Author(s): Partin JC, Partin JS, Schubert WK, Jacobs R, Saalfeld K. Source: Lancet. 1976 September 18; 2(7986): 599-602. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=61342&dopt=Abstract

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Jamaican vomiting sickness and Reye's syndrome. Author(s): Trauner DA, Nyhan WL, Sweetman L. Source: The New England Journal of Medicine. 1976 December 23; 295(26): 1481-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=995147&dopt=Abstract

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Jamshedpur fever and Reye's syndrome. Author(s): Olson LC. Source: Jama : the Journal of the American Medical Association. 1984 August 3; 252(5): 627. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6737664&dopt=Abstract

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Jamshedpur fever and Reye's syndrome. Author(s): Khan N. Source: Jama : the Journal of the American Medical Association. 1983 August 26; 250(8): 1025. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6348317&dopt=Abstract

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Juvenile atherosclerosis and Reye's syndrome. Author(s): Johannsson JH, Robertson AL Jr. Source: Paroi Arterielle. 1978 January-February; 4(2): 79-87. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=652384&dopt=Abstract

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Labeling for oral and rectal over-the-counter drug products containing aspirin and nonaspirin salicylates; Reye's Syndrome warning. Final rule. Author(s): Food and Drug Administration, HHS. Source: Federal Register. 2003 April 17; 68(74): 18861-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12701599&dopt=Abstract

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Lactic acidemia in Reye's syndrome. Author(s): Tonsgard JH, Huttenlocher PR, Thisted RA. Source: Pediatrics. 1982 January; 69(1): 64-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7054762&dopt=Abstract

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Lesson of the week: Reye's syndrome and aspirin: lest we forget. Author(s): McGovern MC, Glasgow JF, Stewart MC. Source: Bmj (Clinical Research Ed.). 2001 June 30; 322(7302): 1591-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11431304&dopt=Abstract

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Letter: A case of Reye's syndrome. Author(s): Smith AD, Horwood SP. Source: Can Med Assoc J. 1973 December 1; 109(11): 1077. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4586273&dopt=Abstract

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Letter: Association of hyperaminoacidemia and lactic acidosis in Reye's syndrome. Author(s): Moore TA 3rd. Source: The Journal of Pediatrics. 1974 September; 85(3): 440-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4431510&dopt=Abstract

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Letter: Carbamyl phosphate synthetase and ornithine transcarbamylase in liver of Reye's syndrome. Author(s): Brown T, Brown H, Lansky L, Hug G. Source: The New England Journal of Medicine. 1974 October 10; 291(15): 797-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4414133&dopt=Abstract

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Letter: Citrulline for Reye's syndrome. Author(s): DeLong GR, Glick TH, Shannon DC. Source: The New England Journal of Medicine. 1974 June 27; 290(26): 1488. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4831769&dopt=Abstract

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Letter: Clinical diagnosis of Reye's syndrome. Author(s): Bhagwat AG. Source: British Medical Journal. 1974 May 4; 2(913): 272-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4827080&dopt=Abstract

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Letter: Clinical diagnosis of Reye's syndrome. Author(s): Kang E. Source: British Medical Journal. 1974 March 16; 1(906): 518-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4206130&dopt=Abstract

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Letter: Controlled trial of therapy in Reye's syndrome. Author(s): Mowat AP, Neville BG. Source: British Medical Journal. 1975 October 11; 4(5988): 102. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1182461&dopt=Abstract

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Letter: Excessive free fatty acidemia and the encephalopathy in Reye's syndrome. Author(s): Brown RE. Source: The New England Journal of Medicine. 1975 June 12; 292(24): 1297-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1128598&dopt=Abstract

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Letter: Hypophosphataemia in Reye's syndrome. Author(s): Keating JP, Karl IE, DeVivo DC, Haymond MW. Source: Lancet. 1975 July 5; 2(7923): 39-40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=49637&dopt=Abstract

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Letter: Hypothermic total body-washout with survival in Reye's syndrome. Author(s): Lansky LL, Fixley M, Romig DA, Keitges PW, Boggan M, Reis RL. Source: Lancet. 1974 October 26; 2(7887): 1019. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4138322&dopt=Abstract

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Letter: Influenza B and prevention of Reye's syndrome. Author(s): Johnson GM. Source: The New England Journal of Medicine. 1974 June 6; 290(23): 1326. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4827636&dopt=Abstract

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Letter: Lysine metabolism in Reye's syndrome. Author(s): Shih VE, Glick TH, Bercu BB. Source: Lancet. 1974 July 20; 2(7873): 163-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4135529&dopt=Abstract

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Letter: Ornithine or citrulline therapy in treatment of Reye's syndrome. Author(s): Tremblay GC. Source: The New England Journal of Medicine. 1975 January 16; 292(3): 160-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1207715&dopt=Abstract

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Letter: Recurrence of Reye's syndrome. Author(s): Glasgow JF, Halliday HL. Source: Lancet. 1976 May 1; 1(7966): 974. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=57391&dopt=Abstract

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Letter: Respiratory-distress syndrome of the newborn, Reye's syndrome, and fatty acids. Author(s): Brown RE, Drake RM. Source: Lancet. 1974 November 23; 2(7891): 1271-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4139513&dopt=Abstract

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Letter: Reye's syndrome and its treatment. Author(s): Mendoza SA, Schneider JA. Source: Pediatrics. 1974 May; 53(5): 769. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4826739&dopt=Abstract

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Letter: Reye's syndrome and the kinetics of ornithine carbamoyltransferase. Author(s): Lee AR, Balinsky JB, Rossouw JE. Source: Lancet. 1975 September 27; 2(7935): 606. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=51430&dopt=Abstract

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Letter: Reye's syndrome in a newborn. Author(s): Kang ES. Source: Can Med Assoc J. 1974 April 20; 110(8): 886. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4824958&dopt=Abstract

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Letter: Reye's syndrome of children and the fatty-liver-and-kidney syndrome of chickens. Author(s): Wight PA, Siller WG, Evans AJ, Bannister DW, Whitehead CC, Blair R. Source: Lancet. 1975 June 14; 1(7920): 1339. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=49537&dopt=Abstract

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Letter: Reye's syndrome or not? Author(s): Bhagwat AG, Chandrasekharan R, Banerji CK, Kumar V. Source: Lancet. 1974 September 7; 2(7880): 593-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4140303&dopt=Abstract

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Letter: Reye's syndrome. Author(s): Brown T, Hug G, Bove K, Brown H, Lansky L. Source: Lancet. 1974 September 21; 2(7882): 716-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4142983&dopt=Abstract

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Letter: Reye's syndrome. Author(s): Thaler MM, Hoogenraad NJ. Source: Lancet. 1975 December 6; 2(7945): 1154. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=53646&dopt=Abstract

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Letter: Reye's syndrome. Author(s): Liang DC. Source: Lancet. 1975 September 27; 2(7935): 607. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=51433&dopt=Abstract

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Letter: Reye's syndrome: a viral myopathy? Author(s): Alvira MM, Mendoza M. Source: The New England Journal of Medicine. 1975 June 12; 292(24): 1297. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1128597&dopt=Abstract

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Letter: Reye's syndrome--virus or artifact in muscle? Author(s): Hanson PA, Urizar RE. Source: The New England Journal of Medicine. 1975 September 4; 293(10): 505-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1152868&dopt=Abstract

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Letter: Role of influenza B infections in Reye's syndrome. Author(s): Regan RP. Source: Postgraduate Medicine. 1974 June; 55(6): 21. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4831489&dopt=Abstract

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Letter: Role of ornithine transcarbamylase in Reye's syndrome. Author(s): Thaler MM. Source: The New England Journal of Medicine. 1974 October 10; 291(15): 797. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4414380&dopt=Abstract

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Letter: The need for control study in Reye's syndrome. Author(s): Albers WH. Source: Pediatrics. 1975 April; 55(4): 569-70. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1128975&dopt=Abstract

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Leukemia following Reye's syndrome treated with exchange transfusions: search for type-C viral infection. Author(s): Overturf GD, Powars DR, McAllister RM, Pegelow C, Charman HP. Source: Medical and Pediatric Oncology. 1977; 3(4): 345-50. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=200832&dopt=Abstract

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Leukocyte tubuloreticular inclusions in Reye's syndrome. Author(s): Tang TT, Harb JM, Grossberg SE, Sedmak GV, Murphy JV. Source: Archives of Pathology & Laboratory Medicine. 1985 June; 109(6): 543-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2581524&dopt=Abstract

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Life-threatening intracranial hypertension in Reye's syndrome treated with intravenous thiopentone. Author(s): McWilliam RC, Stephenson JB. Source: European Journal of Pediatrics. 1985 November; 144(4): 383-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4076255&dopt=Abstract

40 Reye’s Syndrome

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Lipid and lipoprotein studies in Reye's syndrome. Author(s): Brown RE, Madge GE, Trauner DA, David RB. Source: Va Med Mon (1918). 1972 June; 99(6): 622-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5033677&dopt=Abstract

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Liver coenzyme A ester content: comparison between Reye's syndrome and control subjects. Author(s): Kang ES, Capaci MT, Korones DN, Tekade N. Source: Clinical Science (London, England : 1979). 1982 November; 63(5): 455-60. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7116786&dopt=Abstract

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Liver function abnormalities in the course of a type A (H1N1) influenza outbreak: relation to Reye's syndrome. Author(s): Monto AS, Ceglarek JP, Hayner NS. Source: American Journal of Epidemiology. 1981 November; 114(5): 750-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7304602&dopt=Abstract

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Liver ultrastructure in mitochondrial urea cycle enzyme deficiencies and comparison with Reye's syndrome. Author(s): Latham PS, LaBrecque DR, McReynolds JW, Klatskin G. Source: Hepatology (Baltimore, Md.). 1984 May-June; 4(3): 404-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6724509&dopt=Abstract

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Long-lasting memory deficits in children recovered from Reye's syndrome. Author(s): Quart EJ, Buchtel HA, Sarnaik AP. Source: J Clin Exp Neuropsychol. 1988 August; 10(4): 409-20. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3403704&dopt=Abstract

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Lowering of intracranial pressure in Reye's syndrome by sensory stimulation. Author(s): Pollack LD, Goldstein GW. Source: The New England Journal of Medicine. 1981 March 19; 304(12): 732. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7464873&dopt=Abstract

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Management of Reye's syndrome. Author(s): Swedlow DB, Schreiner MS. Source: Critical Care Clinics. 1985 July; 1(2): 285-311. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3916781&dopt=Abstract

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Management of Reye's syndrome. Author(s): Goldschmidt MN, Bailey DW. Source: The New England Journal of Medicine. 1972 August 3; 287(5): 255. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5037505&dopt=Abstract

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Management of Reye's syndrome. A rational approach to a complex problem. Author(s): Boutros A, Hoyt J, Menezes A, Bell W. Source: Critical Care Medicine. 1977 September-October; 5(5): 234-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=902493&dopt=Abstract

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Management of Reye's syndrome: a rational approach to a complex problem. Author(s): Sarnaik AP. Source: Indian J Pediatr. 1982 September-October; 49(400): 707-14. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6821324&dopt=Abstract

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Management of Reye's syndrome: need for early diagnosis and intravenous treatment of stage I non-comatose cases. Author(s): Partin JC. Source: Pediatric Annals. 1985 July; 14(7): 511, 514-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4022667&dopt=Abstract

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Margosa oil poisoning as a cause of Reye's syndrome. Author(s): Sinniah D, Baskaran G. Source: Lancet. 1981 February 28; 1(8218): 487-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6110100&dopt=Abstract

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Masking by enzyme inhibitor of raised serum glutamate dehydrogenase activity in Reye's syndrome. Author(s): Holt JT, Arvan DA, Mayer TK. Source: Lancet. 1983 July 2; 2(8340): 4-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6134899&dopt=Abstract

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Measurement of true salicylate concentrations in serum from patients with Reye's syndrome. Author(s): Kang ES, Todd TA, Capaci MT, Schwenzer K, Jabbour JT. Source: Clinical Chemistry. 1983 June; 29(6): 1012-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6851086&dopt=Abstract

42 Reye’s Syndrome

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Medium and long chain serum free fatty acids in a case of Reye's syndrome. Author(s): Ogburn PL. Source: Southern Medical Journal. 1976 May; 69(5): 632-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1273626&dopt=Abstract

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Medium-chain and long-chain acyl CoA dehydrogenase deficiency: clinical, pathologic and ultrastructural differentiation from Reye's syndrome. Author(s): Treem WR, Witzleben CA, Piccoli DA, Stanley CA, Hale DE, Coates PM, Watkins JB. Source: Hepatology (Baltimore, Md.). 1986 November-December; 6(6): 1270-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3793003&dopt=Abstract

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Metabolic disorder possible cause of Reye's syndrome. Author(s): Kelley RI, Coates PM, Hale DE, Stanley CA. Source: Am J Dis Child. 1986 April; 140(4): 328-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3953520&dopt=Abstract

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Metabolic disorders mimicking Reye's syndrome. Author(s): Chang PF, Huang SF, Hwu WL, Hou JW, Ni YH, Chang MH. Source: J Formos Med Assoc. 2000 April; 99(4): 295-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10870312&dopt=Abstract

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Michigan studies of Reye's Syndrome, aspirin, suggest preventive measures available. Author(s): Hall W. Source: Mich Med. 1981 September; 80(26): 486-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7289892&dopt=Abstract

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Mild Reye's syndrome in an adult. Author(s): Lecky BR, Winer JB, Kenwright S. Source: Journal of Neurology, Neurosurgery, and Psychiatry. 1984 August; 47(8): 885-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6470734&dopt=Abstract

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Mitochondria in Reye's syndrome. Author(s): Thaler MM, Partin JC, Schubert WK, Partin JS. Source: The New England Journal of Medicine. 1972 February 24; 286(8): 434-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5009238&dopt=Abstract

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Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera). Author(s): Partin JC, Schubert WK, Partin JS. Source: The New England Journal of Medicine. 1971 December 9; 285(24): 1339-43. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5121185&dopt=Abstract

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Molecular integrity of aspirin in relation to Reye's syndrome. Author(s): Caveney S. Source: W V Med J. 1988 May; 84(5): 186-90. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3376471&dopt=Abstract

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Monitoring serum osmolality in mannitol treatment of Reye's syndrome. Author(s): Newman SL. Source: The New England Journal of Medicine. 1979 October 25; 301(17): 945-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=481550&dopt=Abstract

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Monoclonal antibody therapy in the treatment of Reye's syndrome. Author(s): Treon SP, Broitman SA. Source: Medical Hypotheses. 1992 November; 39(3): 238-42. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1474950&dopt=Abstract

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Morphologic grading of hepatic mitochondrial alteration in Reye's syndrome: potential prognostic implication. Author(s): Chang CH, Uchwat F, Masalskis F, Arcinue EL. Source: Pediatr Pathol. 1985; 4(3-4): 265-75. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3835551&dopt=Abstract

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Mortality due to Reye's syndrome in Michigan: distribution and longitudinal trends. Author(s): Luscombe FA, Monto AS, Baublis JV. Source: The Journal of Infectious Diseases. 1980 September; 142(3): 363-71. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7441007&dopt=Abstract

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Motor disorders of voice and speech in Reye's syndrome survivors. Author(s): Reitman MA, Casper J, Coplan J, Weiner LB, Kellman RM, Kanter RK. Source: Am J Dis Child. 1984 December; 138(12): 1129-31. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6507395&dopt=Abstract

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Multiple hornet stings with features of Reye's syndrome. Author(s): Weizman Z, Mussafi H, Ishay JS, Shvil Y, Goitein K, Livni N, Deckelbaum RJ. Source: Gastroenterology. 1985 December; 89(6): 1407-10. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4054532&dopt=Abstract

44 Reye’s Syndrome

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Mumps and varicella vs. Reye's syndrome. Author(s): Lerman SJ. Source: Clinical Pediatrics. 1972 October; 11(10): 10A Passim. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5078525&dopt=Abstract

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Mumps and varicella vs. Reye's syndrome. Author(s): Szalay GC. Source: Clinical Pediatrics. 1972 October; 11(10): 10 Passim. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5078524&dopt=Abstract

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Myocardial mitochondrial calcifiction in Reye's syndrome. Author(s): Hammar SP, Krous H. Source: Human Pathology. 1977 January; 8(1): 95-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=844857&dopt=Abstract

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Myth & facts... about Reye's syndrome. Author(s): Quillen TM. Source: Nursing. 1996 May; 26(5): 17. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8710277&dopt=Abstract

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Necessity of liver biopsy for accurate diagnosis of Reye's syndrome. Author(s): Kimura A, Yoshida I, Yamashita F. Source: Journal of Pediatric Gastroenterology and Nutrition. 1987 January-February; 6(1): 153-4. Erratum In: J Pediatr Gastroenterol Nutr 1987 May-June; 6(3): 489. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3794930&dopt=Abstract

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Necrosis of the forearm following radial artery catheterization in a patient with Reye's syndrome. Author(s): Mayer T, Matlak ME, Thompson JA. Source: Pediatrics. 1980 January; 65(1): 141-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7355010&dopt=Abstract

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Neurological and intellectual sequelae of Reye's syndrome. Author(s): Davidson PW, Willoughby RH, O'Tuama LA, Swisher CN, Benjamins D. Source: Am J Ment Defic. 1978 May; 82(6): 535-41. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=655200&dopt=Abstract

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Neuropathologic features, including pontine schwannosis, in a four-year survivor of probable Reye's syndrome with secondary Mobius syndrome. Author(s): Manz HJ, Cochran W. Source: Childs Brain. 1984; 11(2): 126-34. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6723427&dopt=Abstract

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Non-icteric fulminant hepatitis and Reye's syndrome: comparison of laboratory data. Author(s): Shibao K. Source: Acta Paediatr Jpn. 1990 August; 32(4): 399-405. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2288222&dopt=Abstract

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Nursing care study: Reye's syndrome. Author(s): Edwards M. Source: Nurs Times. 1977 July 7; 73(27): 1039-40. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=882406&dopt=Abstract

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Observations on the pathogenesis of Reye's syndrome. Author(s): Brown RE, Madge GE, Schiller HM. Source: Southern Medical Journal. 1971 August; 64(8): 942-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5565332&dopt=Abstract

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Organic acids and Reye's syndrome. Author(s): Applegarth DA, MacLeod PM, Toone JR, Kirby LT, MacLean JR, Mamer OA, Montgomery JA. Source: Lancet. 1979 May 26; 1(8126): 1147. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=86873&dopt=Abstract

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Ornithine carbamyl transferase in Reye's syndrome. Author(s): Deshmukh DR, Remington PL. Source: Biochem Med. 1984 December; 32(3): 337-40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6517878&dopt=Abstract

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Our experience in Reye's syndrome. Author(s): Kutukculer N, Yagci RV. Source: Journal of Pediatric Gastroenterology and Nutrition. 1996 October; 23(3): 338-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8890094&dopt=Abstract

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Pancreatitis and Reye's syndrome. Author(s): Ellis GH, Mirkin LD, Mills MC. Source: Am J Dis Child. 1979 October; 133(10): 1014-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=495590&dopt=Abstract

46 Reye’s Syndrome

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Pancreatitis in patients with Reye's syndrome. Author(s): Glassman M, Tahan S, Hillemeier C, Rothstein P, Shaywitz BA, Gryboski J. Source: Journal of Clinical Gastroenterology. 1981 June; 3(2): 165-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7240693&dopt=Abstract

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Pancreatitis in Reye's syndrome. Author(s): Banks PA. Source: Journal of Clinical Gastroenterology. 1981 June; 3(2): 201-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7240700&dopt=Abstract

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Partial carbamyl phosphate synthetase deficiency, simulating Reye's syndrome, in a 9-year-old girl. Author(s): Granot E, Matoth I, Lotan C, Shvil Y, Lijovetzky G, Yatziv S. Source: Isr J Med Sci. 1986 June; 22(6): 463-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3759432&dopt=Abstract

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Pathogenesis of Reye's syndrome: A working hypothesis. Author(s): Thaler MM. Source: Pediatrics. 1975 December; 56(6): 1081-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1196760&dopt=Abstract

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Pathology of the liver in Reye's syndrome. Author(s): Svoboda DJ, Reddy JK. Source: Laboratory Investigation; a Journal of Technical Methods and Pathology. 1975 May; 32(5): 571-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1127876&dopt=Abstract

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Pediatric ibuprofen use increases while incidence of Reye's syndrome continues to decline. Author(s): Prior MJ, Nelson EB, Temple AR. Source: Clinical Pediatrics. 2000 April; 39(4): 245-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10791139&dopt=Abstract

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Pediatric management problems (Reye's syndrome). Author(s): Castiglia PT, Aquilina S. Source: Pediatric Nursing. 1984 March-April; 10(2): 156-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6561516&dopt=Abstract

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Pentobarbital quantitation using immunoassays in Reye's syndrome patient serum. Author(s): Turley CP. Source: Therapeutic Drug Monitoring. 1989; 11(3): 343-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2728092&dopt=Abstract

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Pentobarbital therapy for intracranial hypertension in metabolic coma. Reye's syndrome. Author(s): Marshall LF, Shapiro HM, Rauscher A, Kaufman NM. Source: Critical Care Medicine. 1978 January-February; 6(1): 1-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=639524&dopt=Abstract

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Peptic ulcer in Reye's syndrome. Author(s): Manning R, Kearney PJ. Source: British Medical Journal (Clinical Research Ed.). 1983 October 15; 287(6399): 1105. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6414584&dopt=Abstract

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Periportal hepatic necrosis in Reye's syndrome. One case in a review of eight patients. Author(s): Bentz MS, Cohen C. Source: The American Journal of Gastroenterology. 1980 January; 73(1): 49-53. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7377172&dopt=Abstract

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Plans for future influenza pandemics must raise awareness of Reye's syndrome. Author(s): Hall S, Lynn R. Source: Bmj (Clinical Research Ed.). 1998 July 25; 317(7153): 284. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9677238&dopt=Abstract

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Platelet-monoamine oxidase activity in Reye's syndrome. Author(s): Faraj BA, Newman SL, Caplan DB, Ahmann PA, Kutner M, Ali FM, Lindahl JA. Source: Journal of Pediatric Gastroenterology and Nutrition. 1985 August; 4(4): 532-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4032164&dopt=Abstract

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Polygraphic recordings in a case of Reye's syndrome. Author(s): Fernandez H, Smith JB, McGraw P, Toole JF. Source: Journal of Clinical Ultrasound : Jcu. 1976 October; 4(5): 365-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=824318&dopt=Abstract

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Possible pathogenic role of endotoxin in Reye's syndrome. Author(s): Cooperstock MS, Tucker RP, Baublis JV. Source: Lancet. 1975 June 7; 1(7919): 1272-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=48899&dopt=Abstract

48 Reye’s Syndrome

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Possible role of lysolecithins and nonesterified fatty acids in the pathogenesis of Reye's syndrome, sudden infant death syndrome, acute pancreatitis, and diabetic ketoacidosis. Author(s): Shaw W. Source: Clinical Chemistry. 1985 July; 31(7): 1109-15. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3924439&dopt=Abstract

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Post-influenzal encephalitis and Reye's syndrome. Author(s): Harrington M, Draper IT. Source: Journal of Neurology, Neurosurgery, and Psychiatry. 1981 July; 44(7): 649. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7288455&dopt=Abstract

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Potential hazard of therapy for Reye's syndrome with urea cycle intermediates. Author(s): Glasgow AM. Source: Pediatrics. 1977 October; 60(4): 557-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=905032&dopt=Abstract

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Potential therapeutic pitfalls in Reye's syndrome. Author(s): Brown RE, Mullick FG, Madge GE. Source: Pediatrics. 1973 October; 52(4): 491-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4742242&dopt=Abstract

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Preadmission antipyretics in Reye's syndrome. Author(s): Hall SM, Plaster PA, Glasgow JF, Hancock P. Source: Archives of Disease in Childhood. 1988 July; 63(7): 857-66. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3415311&dopt=Abstract

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Presence of aflatoxin B1 in human liver referred to as Reye's syndrome in Venezuela. Author(s): Burguera JA. Source: Acta Cient Venez. 1986; 37(3): 325-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3113145&dopt=Abstract

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Preservation of mitochondrial enzymes in brain and muscle in Reye's syndrome. Author(s): Partin JS. Source: Pediatric Research. 1979 July; 13(7): 868-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=481961&dopt=Abstract

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Prior history of learning disabilities in Reye's syndrome survivors. Author(s): Quart EJ, Cruickshank WM, Sarnaik A. Source: Journal of Learning Disabilities. 1985 June-July; 18(6): 345-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4020289&dopt=Abstract

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Problems in case definition of Reye's syndrome. Author(s): Ko KW. Source: Acta Paediatr Jpn. 1990 August; 32(4): 381-4. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2288219&dopt=Abstract

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Prognostic value of electroencephalography in Reye's syndrome. Author(s): Aoki Y, Lombroso C. Source: Neurology. 1973 April; 23(4): 333-43. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4736121&dopt=Abstract

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Prolactin and the encephalopathy of Reye's syndrome. Author(s): Newman SL, Faraj BA, Caplan DB, Ali FM, Camp VM, Ahmann PA. Source: Lancet. 1979 November 24; 2(8152): 1097-100. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=91838&dopt=Abstract

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Prolonged continuous monitoring of intracranial pressure in severe Reye's syndrome. Author(s): Shaywitz BA, Leventhal JM, Kramer MS, Venes JL. Source: Pediatrics. 1977 April; 59(4): 595-605. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=850599&dopt=Abstract

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Public Health Service study of Reye's syndrome and medications. Report of the main study. Author(s): Hurwitz ES, Barrett MJ, Bregman D, Gunn WJ, Pinsky P, Schonberger LB, Drage JS, Kaslow RA, Burlington DB, Quinnan GV, et al. Source: Jama : the Journal of the American Medical Association. 1987 April 10; 257(14): 1905-11. Erratum In: Jama 1987 June 26; 257(24): 3366. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3820509&dopt=Abstract

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Public Health Service study on Reye's syndrome and medications. Report of the pilot phase. Author(s): Hurwitz ES, Barrett MJ, Bregman D, Gunn WJ, Schonberger LB, Fairweather WR, Drage JS, LaMontagne JR, Kaslow RA, Burlington DB, et al. Source: The New England Journal of Medicine. 1985 October 3; 313(14): 849-57. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4033715&dopt=Abstract

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Pulmonary findings in Reye's syndrome. Clinicopathologic features. Author(s): Brown RE, Madge GE. Source: Arch Pathol. 1971 December; 92(6): 475-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5121034&dopt=Abstract

50 Reye’s Syndrome

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Recognition and early management of Reye's syndrome. Author(s): Dezateux CA, Dinwiddie R, Helms P, Matthew DJ. Source: Archives of Disease in Childhood. 1986 July; 61(7): 647-51. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3740903&dopt=Abstract

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Recognizing a case of Reye's syndrome. Author(s): Quam DA. Source: American Family Physician. 1994 November 15; 50(7): 1491-6. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7976984&dopt=Abstract

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Recurrent Reye's syndrome without liver lipid deposition. Author(s): Cox KL, Cannon RA. Source: Hosp Pract (Hosp Ed). 1981 February; 16(2): 45-51. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7193176&dopt=Abstract

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Recurrent Reye's syndrome. Author(s): Schubert WK. Source: Am J Dis Child. 1979 June; 133(6): 657-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=443227&dopt=Abstract

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Recurrent Reye's syndrome. Author(s): Newman SL. Source: Am J Dis Child. 1979 June; 133(6): 657. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=443226&dopt=Abstract

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Recurrent Reye's syndrome. Author(s): Pichichero ME, McCabe ER. Source: Am J Dis Child. 1978 November; 132(11): 1097-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=717318&dopt=Abstract

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Red blood cell insulin binding studies in Reye's syndrome survivors and families. Author(s): Kang ES, Solomon SS, Gates RE, Schaeffer SJ. Source: Endocr Res Commun. 1982; 9(2): 121-33. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6761105&dopt=Abstract

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Reduced activity of otc in the liver of a patient with Reye's syndrome. Author(s): Arashima S, Takekoshi Y, Anakura M, Nanbu H, Matsuda I. Source: Advances in Experimental Medicine and Biology. 1982; 153: 163-70. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7164895&dopt=Abstract

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Reduction of deaths after drug labelling for risk of Reye's syndrome. Author(s): Shindell S. Source: Lancet. 1993 January 9; 341(8837): 119. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8093390&dopt=Abstract

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Reduction of deaths after drug labelling for risk of Reye's syndrome. Author(s): Casteels-Van Daele M. Source: Lancet. 1993 January 9; 341(8837): 118-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8093388&dopt=Abstract

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Reduction of deaths after drug labelling for risk of Reye's syndrome. Author(s): Davis DL, Buffler P. Source: Lancet. 1992 October 24; 340(8826): 1042. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1357433&dopt=Abstract

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Renal transplantation in Reye's syndrome: fate of the recipient--a case report. Author(s): Richardson CC, Warner OG, Callender CO. Source: The Journal of Urology. 1979 April; 121(4): 497-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=374752&dopt=Abstract

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Repeat liver biopsy in Reye's syndrome. Author(s): Klein M, Raifman M, Phillips J. Source: Am J Dis Child. 1977 October; 131(10): 1174. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=910775&dopt=Abstract

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Report of the New Brunswick Task Force on the Environment and Reye's syndrome. Author(s): Spitzer WO. Source: Clinical and Investigative Medicine. Medecine Clinique Et Experimentale. 1982; 5(2-3): 203-14. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7116727&dopt=Abstract

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Research, improved care lowering Reye's Syndrome death rate. Author(s): Smith M. Source: Mich Med. 1980 June; 79(17): 319-20. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7207240&dopt=Abstract

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Retinol binding protein and prealbumin in Reye's syndrome. Author(s): Bosin E, Glasgow AM, Monji N. Source: Clinical Biochemistry. 1986 June; 19(3): 189-91. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3731437&dopt=Abstract

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Reye syndrome. Author(s): Kamienski MC. Source: The American Journal of Nursing. 2003 July; 103(7): 54-7. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12865641&dopt=Abstract

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Reye's syndrome (acute encephalopathy and fatty degeneration of the viscera). Author(s): Bell WE. Source: J Iowa Med Soc. 1977 May; 67(5): 164-6,178,187. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=858952&dopt=Abstract

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Reye's syndrome (encephalopathy and fatty liver). Diagnosis and treatment. Author(s): Partin JC. Source: Gastroenterology. 1975 August; 69(2): 511-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1150054&dopt=Abstract

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Reye's syndrome 30 years on. Author(s): Glasgow JF, Moore R. Source: Bmj (Clinical Research Ed.). 1993 October 16; 307(6910): 950-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8241901&dopt=Abstract

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Reye's syndrome among patients with juvenile rheumatoid arthritis. Author(s): Sullivan KM, Remington PL, Hurwitz ES, Halpin TJ. Source: Jama : the Journal of the American Medical Association. 1988 December 16; 260(23): 3434-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3210279&dopt=Abstract

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Reye's syndrome and analgesic choice in dentistry. Author(s): Holmes A, Davidson LE. Source: British Dental Journal. 1989 November 25; 167(10): 345-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2590571&dopt=Abstract

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Reye's syndrome and aspirin use: a possible immunological relationship. Author(s): Bailey JM, Low CE, Pupillo MB. Source: Prostaglandins Leukot Med. 1982 March; 8(3): 211-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6952287&dopt=Abstract

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Reye's syndrome and aspirin. Author(s): Andreoli A, Bonora G, Luciani L, Perletti L. Source: Lancet. 1988 September 17; 2(8612): 684. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2901540&dopt=Abstract

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Reye's syndrome and aspirin. Author(s): Danks DM. Source: Lancet. 1987 October 10; 2(8563): 864. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2889071&dopt=Abstract

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Reye's syndrome and aspirin. Author(s): Rowe PH. Source: Journal of the Royal Society of Medicine. 1987 May; 80(5): 325-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3612668&dopt=Abstract

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Reye's syndrome and aspirin. Author(s): Tarlow M. Source: British Medical Journal (Clinical Research Ed.). 1986 June 14; 292(6535): 1543-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3087507&dopt=Abstract

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Reye's syndrome and aspirin. Author(s): Mann RD. Source: J R Coll Gen Pract. 1986 September; 36(290): 418-21. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3806491&dopt=Abstract

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Reye's syndrome and aspirin. Evidence for a dose-response effect. Author(s): Pinsky PF, Hurwitz ES, Schonberger LB, Gunn WJ. Source: Jama : the Journal of the American Medical Association. 1988 August 5; 260(5): 657-61. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3392791&dopt=Abstract

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Reye's syndrome and aspirin: a review. Author(s): Hall SM. Source: Br J Clin Pract Suppl. 1990 August; 70: 4-11. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2081107&dopt=Abstract

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Reye's syndrome and aspirin: a review. Author(s): Hall SM. Source: Journal of the Royal Society of Medicine. 1986 October; 79(10): 596-8. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3537289&dopt=Abstract

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Reye's syndrome and aspirin: guilt by association. Author(s): Feely J. Source: Ir Med J. 1986 October; 79(10): 269-70. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3793418&dopt=Abstract

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Reye's syndrome and cerebellar intracytoplasmic inclusion bodies. Author(s): Turel AP Jr, Levinsohn MW, Derakhshan I, Gutierrez Y. Source: Archives of Neurology. 1975 September; 32(9): 624-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=169767&dopt=Abstract

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Reye's syndrome and hyperaminoacidemia. Author(s): Hilty MD, Romshe CA, Delamater PV. Source: The Journal of Pediatrics. 1974 March; 84(3): 362-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4811987&dopt=Abstract

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Reye's syndrome and juvenile rheumatoid arthritis: a case report in Texas. Author(s): Roman GC, Munden PM, Waagner D, Ledbetter EO. Source: Tex Med. 1987 October; 83(10): 46-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3672387&dopt=Abstract

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Reye's syndrome and medication use. Author(s): Halpin TJ, Holtzhauer FJ, Campbell RJ, Hall LJ, Correa-Villasenor A, Lanese R, Rice J, Hurwitz ES. Source: Jama : the Journal of the American Medical Association. 1982 August 13; 248(6): 687-91. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7097918&dopt=Abstract

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Reye's syndrome and organ transplantation. Author(s): Mauer SM. Source: Lancet. 1985 May 18; 1(8438): 1164. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2860370&dopt=Abstract

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Reye's syndrome and organ transplantation. Author(s): Donnelly PK, Cook S, Eastham E. Source: Lancet. 1985 February 2; 1(8423): 289. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2857358&dopt=Abstract

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Reye's syndrome and pancreatitis. Author(s): Gilboa N. Source: Am J Dis Child. 1980 September; 134(9): 903. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7416124&dopt=Abstract

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Reye's syndrome and post-influenza-B hepatotoxicity. Author(s): Ashe HS. Source: Wis Med J. 1975 January; 74(1): S7-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1114852&dopt=Abstract

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Reye's syndrome and salicylate use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863. Author(s): Kauffman RE. Source: Pediatrics. 1998 July; 102(1 Pt 2): 259-62. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9729163&dopt=Abstract

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Reye's syndrome and salicylate use. Author(s): Starko KM, Ray CG, Dominguez LB, Stromberg WL, Woodall DF. Source: Pediatrics. 1980 December; 66(6): 859-64. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7454476&dopt=Abstract

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Reye's syndrome and short-chain fatty acids. Author(s): Krause KH, Berlit P, Bonjour JP. Source: Neurology. 1985 January; 35(1): 135-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3965989&dopt=Abstract

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Reye's syndrome and spruce budworm insecticide spraying in Maine, 1978-1982. Author(s): Wood RB Jr, Bogdan GF. Source: American Journal of Epidemiology. 1986 October; 124(4): 671-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3752060&dopt=Abstract

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Reye's syndrome and the Singapore syndrome. Author(s): Aiyathurai JE, Mathew T, Boon WH. Source: J Singapore Paediatr Soc. 1978 August-September; 20(3): 159-67. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=750757&dopt=Abstract

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Reye's syndrome and the use of aspirin. Author(s): Smith TC. Source: Scott Med J. 1996 February; 41(1): 4-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8658122&dopt=Abstract

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Reye's syndrome and viral ketoacidosis. Author(s): Aiyathurai JE. Source: Lancet. 1976 December 4; 2(7997): 1253. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=63082&dopt=Abstract

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Reye's syndrome as a cause of hypoglycemia. Author(s): David S. Source: Pediatrics. 1971 May; 47(5): 959-60. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5573886&dopt=Abstract

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Reye's syndrome associated with acute myocarditis and fatal circulatory failure. Author(s): Lajoie J, Sagy M, Gonzalez R. Source: Pediatric Emergency Care. 1991 August; 7(4): 226-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1758777&dopt=Abstract

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Reye's syndrome associated with acute tubular necrosis. Author(s): Nicholls S, Gill D, Craske J. Source: Archives of Disease in Childhood. 1975 December; 50(12): 960-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1220612&dopt=Abstract

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Reye's syndrome associated with adenovirus infections in infants. Author(s): Edwards KM, Bennett SR, Garner WL, Bratton DL, Glick AD, Greene HL, Wright PF. Source: Am J Dis Child. 1985 April; 139(4): 343-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2983531&dopt=Abstract

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Reye's syndrome associated with adenovirus infections. Author(s): Daugherty CC, Heubi JE. Source: Am J Dis Child. 1985 November; 139(11): 1076. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2998179&dopt=Abstract

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Reye's syndrome associated with adenovirus type 3 infection. Author(s): Brown JM. Source: The Medical Journal of Australia. 1974 December 14; 2(24): 873-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4375785&dopt=Abstract

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Reye's syndrome associated with influenza A and B virus. Author(s): Rao BL, Phadke MA, Joshi AS. Source: Indian Pediatrics. 1982 August; 19(8): 719-22. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7174109&dopt=Abstract

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Reye's syndrome associated with long-term aspirin therapy. Author(s): Young RS, Torretti D, Williams RH, Hendriksen D, Woods M. Source: Jama : the Journal of the American Medical Association. 1984 February 10; 251(6): 754-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6694278&dopt=Abstract

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Reye's syndrome associated with respiratory syncytial virus infection. Author(s): Griffin N, Keeling JW, Tomlinson AH. Source: Archives of Disease in Childhood. 1979 January; 54(1): 74-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=420528&dopt=Abstract

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Reye's syndrome due to a novel protein-tolerant variant of ornithinetranscarbamylase deficiency. Author(s): Thaler MM, Hoogenraad NJ, Boswell M. Source: Lancet. 1974 August 24; 2(7878): 438-40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4137171&dopt=Abstract

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Reye's syndrome in a 17-year-old male: is this disease really disappearing? Author(s): da Silveira EB, Young K, Rodriguez M, Ameen N. Source: Digestive Diseases and Sciences. 2002 September; 47(9): 1959-61. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12353836&dopt=Abstract

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Reye's syndrome in a boy treated with salicylates for Reiter's disease. Author(s): Baboolal R, Monaghan H, Ward OC. Source: Ir Med J. 1986 October; 79(10): 289-91. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3793424&dopt=Abstract

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Reye's syndrome in a child on long-term salicylate medication. Author(s): Christoffersen P, Faarup P, Geertinger P, Krogh P. Source: Forensic Science International. 1980 March-April; 15(2): 129-33. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7358324&dopt=Abstract

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Reye's syndrome in a neonate. Author(s): Harris HB, Vogler LB, Cassady G. Source: Southern Medical Journal. 1976 November; 69(11): 1511-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1019656&dopt=Abstract

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Reye's syndrome in a newborn infant. Author(s): Papageorgiou A, Wiglesworth FW, Schiff D, Stern L. Source: Can Med Assoc J. 1973 October 20; 109(8): 717-20. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4746131&dopt=Abstract

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Reye's syndrome in a young adult. Author(s): Chan ED. Source: Military Medicine. 1993 January; 158(1): 65-8. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8437745&dopt=Abstract

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Reye's syndrome in adult with AIDS. Author(s): Jolliet P, Widmann JJ. Source: Lancet. 1990 June 16; 335(8703): 1457. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1972225&dopt=Abstract

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Reye's syndrome in adults. Author(s): Kolb SE. Source: Critical Care Nurse. 1991 January; 11(1): 73-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1988253&dopt=Abstract

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Reye's syndrome in adults. Author(s): Ede RJ, Williams R. Source: British Medical Journal (Clinical Research Ed.). 1988 February 20; 296(6621): 5178. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3126886&dopt=Abstract

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Reye's syndrome in adults. A case report and review of the literature. Author(s): Peters LJ, Wiener GJ, Gilliam J, Van Noord G, Geisinger KR, Roach ES. Source: Archives of Internal Medicine. 1986 December; 146(12): 2401-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3778077&dopt=Abstract

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Reye's syndrome in adults. Diagnostic considerations. Author(s): Meythaler JM, Varma RR. Source: Archives of Internal Medicine. 1987 January; 147(1): 61-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3800531&dopt=Abstract

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Reye's syndrome in an adult patient. Author(s): Kirkpatrick DB, Ottoson C, Bateman LL. Source: The Western Journal of Medicine. 1986 February; 144(2): 223-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3953091&dopt=Abstract

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Reye's syndrome in an adult. Author(s): Eagel BA, Vinoski B, Krugman D. Source: Conn Med. 1989 January; 53(1): 3-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2706976&dopt=Abstract

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Reye's syndrome in an adult. Author(s): Vanholder R, De Reuck J, Sieben-Praet M, De Coster W. Source: European Neurology. 1979; 18(6): 367-72. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=546659&dopt=Abstract

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Reye's syndrome in an adult. Author(s): Morse RS, Holmes AW, Levin S. Source: Am J Dig Dis. 1975 December; 20(12): 1184-90. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1200012&dopt=Abstract

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Reye's syndrome in an adult: a case report. Author(s): Mehdi S, Franco J. Source: Wmj. 2000 September; 99(6): 23-4, 40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11061022&dopt=Abstract

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Reye's syndrome in Baltimore. A review of 16 cases. Author(s): Walker SH, Schleupner CJ. Source: Md State Med J. 1973 May; 22(5): 48-53. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4707360&dopt=Abstract

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Reye's syndrome in Bangalore. Author(s): Benakappa DG, Das S, Shankar SK, Rao BS, Prakash, George S, Aswath PS, Sastry NS, Benakappa A. Source: Indian J Pediatr. 1991 November-December; 58(6): 805-10. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1818875&dopt=Abstract

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Reye's syndrome in children travelling abroad. Author(s): Donaldson M, Fleming P. Source: Lancet. 1988 November 5; 2(8619): 1073. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2903294&dopt=Abstract

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Reye's syndrome in children under three years old. Author(s): Bellman MH, Ross EM, Miller DL. Source: Archives of Disease in Childhood. 1982 April; 57(4): 259-63. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7082037&dopt=Abstract

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Reye's syndrome in children under two years of age: significance of electroencephalographic observations. Author(s): Hart ZH, Nelson BG, Kooi KA, Baublis JV, Tucker RP. Source: Clin Electroencephalogr. 1981 July; 12(3): 102-12. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7273426&dopt=Abstract

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Reye's syndrome in Denmark. A retrospective study. Author(s): Daugbjerg P, Ranek L. Source: Acta Paediatr Scand. 1986 March; 75(2): 313-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3962663&dopt=Abstract

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Reye's syndrome in Haemophilus influenzae B septicaemia: case report. Author(s): Macgregor DF. Source: Annals of Tropical Paediatrics. 1988 March; 8(1): 42-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2456722&dopt=Abstract

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Reye's syndrome in Hong Kong. Author(s): Yu EC. Source: Aust Paediatr J. 1988 February; 24(1): 61. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3355448&dopt=Abstract

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Reye's syndrome in infancy. Author(s): Huttenlocher PR, Trauner DA. Source: Pediatrics. 1978 July; 62(1): 84-90. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=683788&dopt=Abstract

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Reye's syndrome in Johannesburg. Epidemiology and clinical presentation. Author(s): Hofman KJ, Rosen EU. Source: South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 1982 February 20; 61(8): 281-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7058462&dopt=Abstract

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Reye's syndrome in Malaysian children: a report of three autopsy cases. Author(s): Leong AS. Source: J Singapore Paediatr Soc. 1976 April; 18(1): 38-42. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=966741&dopt=Abstract

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Reye's syndrome in Michigan: the 1974 epidemiologic experience. Author(s): Thompson TR, Gordon RC, Baublis JV. Source: Mich Med. 1975 February; 74(6): 69-73. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1113693&dopt=Abstract

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Reye's syndrome in nonpediatric age groups. Author(s): Varma RR, Riedel DR, Komorowski RA, Harrington GJ, Nowak TV. Source: Jama : the Journal of the American Medical Association. 1979 September 28; 242(13): 1373-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=480558&dopt=Abstract

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Reye's syndrome in Olmsted County, Minnesota: did it exist before 1963? Author(s): Komori S, Ludwig J, Okazaki H, Komori T, Kurland LT. Source: Mayo Clinic Proceedings. 1992 September; 67(9): 871-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1434932&dopt=Abstract

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Reye's syndrome in Rhode Island. Author(s): Brunquell P. Source: R I Med J. 1979 November; 62(11): 429-34. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=293840&dopt=Abstract

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Reye's syndrome in siblings. Author(s): Joseph A, John TJ. Source: Indian Pediatrics. 1971 April; 8(4): 174-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5571293&dopt=Abstract

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Reye's syndrome in South Carolina. Author(s): Key JB, Darby CP. Source: J S C Med Assoc. 1974 November; 70(11): 341-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4530126&dopt=Abstract

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Reye's syndrome in Sri Lanka. Author(s): de Silva DD, Chandrasoma PT, Lamabadusuriya SP. Source: Ceylon Med J. 1975 December; 20(4): 219-24. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1230307&dopt=Abstract

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Reye's syndrome in Thailand. Author(s): Sunakorn P, Kalayanarooj S. Source: Acta Paediatr Jpn. 1990 August; 32(4): 391-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2288221&dopt=Abstract

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Reye's syndrome in the adult patients. Author(s): Atkins JN, Haponik EF. Source: The American Journal of Medicine. 1979 October; 67(4): 672-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=495637&dopt=Abstract

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Reye's syndrome in the adult: case report and review of the literature. Author(s): Stillman A, Gitter H, Shillington D, Sobonya R, Payne CM, Ettinger D, Lee SM. Source: The American Journal of Gastroenterology. 1983 June; 78(6): 365-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6859015&dopt=Abstract

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Reye's syndrome in the British Isles: first annual report of the joint British Paediatric Association and Communicable Disease Surveillance Centre surveillance scheme. Author(s): Hall S, Bellman M. Source: British Medical Journal (Clinical Research Ed.). 1984 February 18; 288(6416): 54850. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6421374&dopt=Abstract

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Reye's syndrome in the British Isles: report for 1990/91 and the first decade of surveillance. Author(s): Newton L, Hall SM. Source: Commun Dis Rep Cdr Rev. 1993 January 1; 3(1): R11-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7689017&dopt=Abstract

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Reye's syndrome in the United States from 1981 through 1997. Author(s): Belay ED, Bresee JS, Holman RC, Khan AS, Shahriari A, Schonberger LB. Source: The New England Journal of Medicine. 1999 May 6; 340(18): 1377-82. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10228187&dopt=Abstract

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Reye's syndrome in the United States in 1977-1978, a non-influenza B virus year. Author(s): Nelson DB, Hurwitz ES, Sullivan-Bolyai JZ, Morens DM, Schonberger LB. Source: The Journal of Infectious Diseases. 1979 September; 140(3): 436-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=501157&dopt=Abstract

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Reye's syndrome in three Israeli children. Possible relationship to warfarin toxicity. Author(s): Mogilner, BM, Freeman JS, Blashar Y, Pincus FE. Source: Isr J Med Sci. 1974 September; 10(9): 1117-25. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4436035&dopt=Abstract

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Reye's syndrome in three siblings. Association with type A influenza infection. Author(s): Wilson R, Miller J, Greene H, Rankin R, Lumeng L, Gordon D, Nelson D, Noble G. Source: Am J Dis Child. 1980 November; 134(11): 1032-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7435460&dopt=Abstract

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Reye's syndrome in twins. Author(s): Thaler MM, Bruhn FW, Applebaum MN, Goodman J. Source: The Journal of Pediatrics. 1970 October; 77(4): 638-46. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5454710&dopt=Abstract

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Reye's syndrome or its metabolic mimics? Author(s): Cannon RA. Source: Hosp Pract (Off Ed). 1984 September; 19(9): 134F-134G, 134K, 134O. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6432814&dopt=Abstract

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Reye's syndrome presenting as atypical sudden infant death syndrome? Author(s): Mason JK, Bain AD. Source: Forensic Science International. 1982 July-August; 20(1): 39-44. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7095676&dopt=Abstract

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Reye's syndrome presenting as suspected appendicitis. Author(s): Nixon SJ, Mendelow AD, Gordon A. Source: Journal of the Royal College of Surgeons of Edinburgh. 1984 January; 29(1): 63-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6708001&dopt=Abstract

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Reye's syndrome reminder. Author(s): Jender C. Source: Journal of Emergency Nursing: Jen : Official Publication of the Emergency Department Nurses Association. 1990 September-October; 16(5): 314. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2214483&dopt=Abstract

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Reye's syndrome report of six autopsied cases. Author(s): Deshpande DH, Shrinivas HV, Rao TV. Source: Indian Pediatrics. 1980 January; 17(1): 3-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7399655&dopt=Abstract

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Reye's syndrome revisited. Outdated concept of Reye's syndrome was used. Author(s): Casteels-Van Daele M, Wouters C, Van Geet C, McGovern MC, Glasgow JF, Stewart MC. Source: Bmj (Clinical Research Ed.). 2002 March 2; 324(7336): 546. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11872565&dopt=Abstract

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Reye's syndrome treated by hemodialysis: a case report. Author(s): Geflman NA, Kranwinkel RN, Pezzimenti JF, Kotch PI, Dean LP, Smith B. Source: Conn Med. 1975 July; 39(7): 405-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1157486&dopt=Abstract

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Reye's syndrome treated by peritoneal dialysis. Author(s): Press DC, Bradford WD, Krueger RP. Source: Pediatrics. 1970 May; 45(5): 845-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5444404&dopt=Abstract

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Reye's syndrome with cortical laminar necrosis: MRI. Author(s): Kinoshita T, Takahashi S, Ishii K, Higano S, Matsumoto K, Sakamoto K, Haginoya K, Iinuma K. Source: Neuroradiology. 1996 April; 38(3): 269-72. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8741200&dopt=Abstract

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Reye's syndrome with respiratory failure. Author(s): Krieger AJ, Trooskin SZ, Detwiler JS. Source: Postgraduate Medicine. 1976 April; 59(4): 239-43. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1264903&dopt=Abstract

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Reye's syndrome without fatty liver. Author(s): Gosseye S, De Meyer R, Maldague P. Source: Helv Paediatr Acta. 1976 April; 30(6): 509-13. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1270322&dopt=Abstract

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Reye's syndrome, salicylates, epidemiology, and public health policy. Author(s): Mortimer EA Jr. Source: Jama : the Journal of the American Medical Association. 1987 April 10; 257(14): 941. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3820516&dopt=Abstract

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Reye's syndrome. Author(s): Deepak S, Raj RS, Sibi NS, Joseph W, Thomas M. Source: J Assoc Physicians India. 2003 January; 51: 89-90. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12693474&dopt=Abstract

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Reye's syndrome. Author(s): Casteels-Van Daele M, Van Geet C, Wouters C, Eggermont E. Source: Lancet. 2001 July 28; 358(9278): 334. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11501538&dopt=Abstract

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Reye's syndrome. Author(s): Johnson GM. Source: The New England Journal of Medicine. 1999 September 9; 341(11): 846-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10490386&dopt=Abstract

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Reye's syndrome. Author(s): Hall SM, Lynn R. Source: The New England Journal of Medicine. 1999 September 9; 341(11): 845-6; Author Reply 846-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10490385&dopt=Abstract

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Reye's syndrome. Author(s): Larsen SU. Source: Med Sci Law. 1997 July; 37(3): 235-41. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9264230&dopt=Abstract

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Reye's syndrome. Author(s): Casteels-Van Daele M, Eggermont E. Source: Bmj (Clinical Research Ed.). 1994 November 26; 309(6966): 1443. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7819876&dopt=Abstract

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Reye's syndrome. Author(s): Hall SM. Source: Bmj (Clinical Research Ed.). 1994 August 6; 309(6951): 411. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8081168&dopt=Abstract

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Reye's syndrome. Author(s): Casteels-van Daele M, Eggermont E. Source: Bmj (Clinical Research Ed.). 1994 April 2; 308(6933): 919-20. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8173388&dopt=Abstract

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Reye's syndrome. Author(s): Alonso K. Source: The American Journal of Forensic Medicine and Pathology : Official Publication of the National Association of Medical Examiners. 1993 March; 14(1): 85-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8493979&dopt=Abstract

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Reye's syndrome. Author(s): Johnson DP. Source: Conn Med. 1989 January; 53(1): 53-4. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2706984&dopt=Abstract

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Reye's syndrome. Author(s): Hurwitz ES. Source: Epidemiologic Reviews. 1989; 11: 249-53. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2680560&dopt=Abstract

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Reye's syndrome. Author(s): Lesna M, Boyd C. Source: British Medical Journal (Clinical Research Ed.). 1986 March 29; 292(6524): 901. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3083936&dopt=Abstract

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Reye's syndrome. Author(s): Glasgow JF, Hicks EM, Jenkins JG, Keilty SR, Black GW, Fannin TF. Source: Br J Hosp Med. 1985 July; 34(1): 42-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4016409&dopt=Abstract

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Reye's syndrome. Author(s): Trauner DA. Source: The Western Journal of Medicine. 1984 August; 141(2): 206-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6495727&dopt=Abstract

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Reye's syndrome. Author(s): Khan N. Source: British Medical Journal (Clinical Research Ed.). 1983 July 9; 287(6385): 128. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6407704&dopt=Abstract

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Reye's syndrome. Author(s): Jemison-Smith P, Hamm P. Source: Crit Care Update. 1983 July; 10(7): 54-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6554160&dopt=Abstract

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Reye's syndrome. Author(s): Miller J, Arsenault L. Source: J Neurosurg Nurs. 1983 June; 15(3): 154-64. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6345731&dopt=Abstract

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Reye's syndrome. Author(s): Rockoff MA, Pascucci RC. Source: Emergency Medicine Clinics of North America. 1983 April; 1(1): 87-100. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6440775&dopt=Abstract

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Reye's syndrome. Author(s): Crocker JF. Source: Seminars in Liver Disease. 1982 November; 2(4): 340-52. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6763346&dopt=Abstract

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Reye's syndrome. Author(s): Richmond DA, Stair T. Source: Annals of Emergency Medicine. 1982 July; 11(7): 379-83. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7091801&dopt=Abstract

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Reye's syndrome. Author(s): Trauner DA. Source: Curr Probl Pediatr. 1982 May; 12(7): 1-31. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7094621&dopt=Abstract

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Reye's syndrome. Author(s): Miller P. Source: Infect Control. 1981 March-April; 2(2): 150-2. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6912206&dopt=Abstract

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Reye's syndrome. Author(s): Datta CK, Reed JB. Source: W V Med J. 1979 October; 75(10): 285-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=294715&dopt=Abstract

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Reye's syndrome. Author(s): Sunakorn P, Rajadanurak K. Source: J Med Assoc Thai. 1975 August; 58(8): 393-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1159341&dopt=Abstract

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Reye's syndrome. Author(s): Nadler HL. Source: Compr Ther. 1975 July; 1(3): 64-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1220906&dopt=Abstract

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Reye's syndrome. Author(s): Gupte S. Source: Indian J Pediatr. 1975 June; 42(329): 176-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1184128&dopt=Abstract

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Reye's syndrome. Author(s): Hutton JT, Levy BS, Hosfield WB. Source: American Family Physician. 1975 March; 11(3): 146-50. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1114934&dopt=Abstract

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Reye's syndrome. Author(s): Kumari S. Source: J La State Med Soc. 1974 May; 126(5): 155-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4840899&dopt=Abstract

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Reye's syndrome. Author(s): Erwin CP. Source: Wis Med J. 1972 November; 71(11): 7-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5083792&dopt=Abstract

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Reye's syndrome. Author(s): Keating JP, DeVivo DC. Source: Mo Med. 1972 November; 69(11): 861-3. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5080097&dopt=Abstract

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Reye's syndrome. Author(s): Human DG. Source: South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 1976 August 28; 50(3F): 1450-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=973164&dopt=Abstract

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Reye's syndrome. Author(s): Riley HD Jr. Source: The Journal of Infectious Diseases. 1972 January; 125(1): 77-81. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5008696&dopt=Abstract

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Reye's syndrome. Author(s): Merrifield JV. Source: W V Med J. 1970 December; 66(12): 415-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5293556&dopt=Abstract

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Reye's syndrome. Author(s): Gray RE, Ryan NJ. Source: J Miss State Med Assoc. 1980 October; 21(10): 211-3. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7431386&dopt=Abstract

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Reye's syndrome. Author(s): Muntean W. Source: Am J Dis Child. 1980 October; 134(10): 999. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7424866&dopt=Abstract

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Reye's syndrome. Author(s): Pais P, Mathias P, Balasubramanium KR. Source: J Indian Med Assoc. 1979 November; 73(9-10): 173-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=547009&dopt=Abstract

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Reye's syndrome. Author(s): Devivo DC, Keating JP. Source: Adv Pediatr. 1976; 22: 175-229. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=817580&dopt=Abstract

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Reye's syndrome. Author(s): Schiff GM. Source: Annual Review of Medicine. 1976; 27: 447-52. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=779608&dopt=Abstract

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Reye's syndrome. Author(s): Schubert WK, Bobo RC, Partin JC, Partin JS. Source: Disease-A-Month : Dm. 1975 December; : 1-30. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1104294&dopt=Abstract

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Reye's syndrome. A diagnosis occasionally first made at medicolegal autopsy. Author(s): Young TW. Source: The American Journal of Forensic Medicine and Pathology : Official Publication of the National Association of Medical Examiners. 1992 March; 13(1): 21-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1585882&dopt=Abstract

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Reye's syndrome. A major disease problem in Thailand. Author(s): Olson LC. Source: J Med Assoc Thai. 1971 September; 54(9): 642-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5126664&dopt=Abstract

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Reye's syndrome. A reappraisal of diagnosis in 49 presumptive cases. Author(s): Gauthier M, Guay J, Lacroix J, Lortie A. Source: Am J Dis Child. 1989 October; 143(10): 1181-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2801659&dopt=Abstract

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Reye's syndrome. A review from the forensic viewpoint. Author(s): Meier FA, Baron JA, Greenberg ER. Source: The American Journal of Forensic Medicine and Pathology : Official Publication of the National Association of Medical Examiners. 1983 December; 4(4): 323-9. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6364791&dopt=Abstract

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Reye's syndrome. An epidemiologic analysis of mild disease. Author(s): Holtzhauer FJ, Campbell RJ, Hall LJ, Halpin TJ. Source: Am J Dis Child. 1986 December; 140(12): 1231-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3776937&dopt=Abstract

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Reye's syndrome. Encephalopathy associated with fatty changes in the viscera in siblings. Author(s): White FP, Rydeen JO. Source: Va Med Mon (1918). 1970 July; 97(7): 434-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5528013&dopt=Abstract

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Reye's syndrome. Encephalopathy in children associated with fatty changes in the viscera. Author(s): Laxdal OE, Sinha RP, Merida J, Wong LC, Stephen JD. Source: Am J Dis Child. 1969 June; 117(6): 717-21. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5771514&dopt=Abstract

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Reye's syndrome. I. Blood ammonia and consideration of the nonhistologic diagnosis. Author(s): Glasgow AM, Cotton RB, Dhiensiri K. Source: Am J Dis Child. 1972 December; 124(6): 827-33. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4639217&dopt=Abstract

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Reye's syndrome. II. Occurrence in the absence of severe fatty infiltration of the liver. Author(s): Glasgow AM, Cotton RB, Bourgeois CH, Dhiensiri K. Source: Am J Dis Child. 1972 December; 124(6): 834-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4639218&dopt=Abstract

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Reye's syndrome. Its relationship to post-infectious encephalitis. Author(s): Faris AA, Jabbour JT. Source: J Med Liban. 1973 April; 26(4): 357-72. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4594346&dopt=Abstract

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Reye's syndrome. Possible causes and pathogenetic pathways. Author(s): Bradford WD, Parker JC Jr. Source: Clinical Pediatrics. 1971 March; 10(3): 148-53. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4927506&dopt=Abstract

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Reye's syndrome. Salicylate metabolism, viral antibody levels, and other factors in surviving patients and unaffected family members. Author(s): Chu AB, Nerurkar LS, Witzel N, Andresen BD, Alexander M, Kang ES, Brouwers P, Fedio P, Lee YJ, Sever JL. Source: Am J Dis Child. 1986 October; 140(10): 1009-12. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3019125&dopt=Abstract

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Reye's syndrome. Two case reports and literature review. Author(s): Sen SK, Subapodok C. Source: Wis Med J. 1972 November; 71(11): 243-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5083789&dopt=Abstract

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Reye's syndrome: 20 years on. Author(s): Mowat AP. Source: British Medical Journal (Clinical Research Ed.). 1983 June 25; 286(6383): 19992001. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6409202&dopt=Abstract

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Reye's syndrome: a case control study of medication use and associated viruses in Australia. Author(s): Orlowski JP, Campbell P, Goldstein S. Source: Cleve Clin J Med. 1990 June; 57(4): 323-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2364532&dopt=Abstract

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Reye's syndrome: a challenge not limited to critical care nurses. Author(s): Dunne RS, Perez RC. Source: Issues in Comprehensive Pediatric Nursing. 1981 July-August; 5(4): 253-63. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6918400&dopt=Abstract

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Reye's syndrome: a clinical review. Author(s): Crocker JF, Bagnell PC. Source: Can Med Assoc J. 1981 February 15; 124(4): 375-82, 425. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6783291&dopt=Abstract

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Reye's syndrome: a devastating childhood illness. Author(s): Hall S. Source: Health Visit. 1983 December; 56(12): 447-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6559775&dopt=Abstract

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Reye's syndrome: a medical mystery. Author(s): Kolata GB. Source: Science. 1980 March 28; 207(4438): 1453-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6767271&dopt=Abstract

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Reye's syndrome: a report of two cases from northern Nigeria. Author(s): Mee J, Nirodi NS, Duggan MB. Source: East Afr Med J. 1979 February; 56(2): 86-91. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=535542&dopt=Abstract

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Reye's syndrome: a report on 674 cases. Author(s): Bear MR. Source: Pas Rep. 1978 June 26; 16(9): 1-12. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10316774&dopt=Abstract

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Reye's syndrome: a review of research studies. Author(s): Lopez TP, Redican KJ, Olsen LK. Source: The Journal of School Health. 1982 April; 52(4): 206-11. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6919693&dopt=Abstract

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Reye's syndrome: a review of six cases. Author(s): Holmes GL. Source: Va Med. 1977 July; 104(7): 466-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=883382&dopt=Abstract

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Reye's syndrome: ammonia intoxication as a possible factor in the encephalopathy. Author(s): Huttenlocher PR, Schwartz AD, Klatskin G. Source: Pediatrics. 1969 March; 43(3): 443-54. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5812402&dopt=Abstract

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Reye's syndrome: an association with influenza A infection. Author(s): Hall BD, Hughes WT Jr, Kmetz D. Source: J Ky Med Assoc. 1969 April; 67(4): 269-71. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5776600&dopt=Abstract

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Reye's syndrome: an update for the practicing physician. Author(s): Volk DM. Source: Clinical Pediatrics. 1981 August; 20(8): 505-11. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6788423&dopt=Abstract

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Reye's syndrome: an update. Author(s): Ward MR. Source: The Nurse Practitioner. 1997 December; 22(12): 45-6, 49-50, 52-3. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9437671&dopt=Abstract

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Reye's syndrome: an update. Author(s): Martelli ME. Source: Journal of Emergency Nursing: Jen : Official Publication of the Emergency Department Nurses Association. 1984 November-December; 10(6): 287-93. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6392665&dopt=Abstract

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Reye's syndrome: are adults big children? Author(s): Latham PS. Source: Hepatology (Baltimore, Md.). 1988 January-February; 8(1): 187-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3338708&dopt=Abstract

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Reye's syndrome: assessment of intracranial monitoring. Author(s): Jenkins JG, Glasgow JF, Black GW, Fannin TF, Hicks EM, Keilty SR, Crean PM. Source: British Medical Journal (Clinical Research Ed.). 1987 February 7; 294(6568): 3378. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3101864&dopt=Abstract

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Reye's syndrome: clinical and pathological features. Author(s): Bellomy BB. Source: J Tenn Med Assoc. 1969 November; 62(11): 1038-41. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5356779&dopt=Abstract

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Reye's syndrome: clinical course and follow-up of survivors. Author(s): Chandrasekaran R, Kumar V, Bannerjee C, Walia BN, Bhagwat AG. Source: Indian Pediatrics. 1973 June; 10(6): 377-81. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4746250&dopt=Abstract

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Reye's syndrome: clinical delineation and evaluation. Author(s): Tang TT, Good TA, Dorrington AJ, McCreadie SR, Siegesmund KA. Source: Wis Med J. 1974 May; 73(5): S49-54. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4830365&dopt=Abstract

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Reye's syndrome: clinical progression and evaluation of therapy. Author(s): Corey L, Rubin RJ, Hattwick MA. Source: Pediatrics. 1977 November; 60(5): 708-14. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=917633&dopt=Abstract

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Reye's syndrome: current concepts. Author(s): Heubi JE, Partin JC, Partin JS, Schubert WK. Source: Hepatology (Baltimore, Md.). 1987 January-February; 7(1): 155-64. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3542776&dopt=Abstract

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Reye's syndrome: diagnosis by muscle biopsy? Author(s): Ozsoylu S. Source: Archives of Disease in Childhood. 1981 December; 56(12): 964. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7332345&dopt=Abstract

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Reye's syndrome: down but not out. Author(s): Bhutta AT, Van Savell H, Schexnayder SM. Source: Southern Medical Journal. 2003 January; 96(1): 43-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12602712&dopt=Abstract

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Reye's syndrome: epidemiologic and viral studies, 1963-1974. Author(s): Linnemann CC Jr, Shea L, Partin JC, Schubert WK, Schiff GM. Source: American Journal of Epidemiology. 1975 June; 101(6): 517-26. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1155430&dopt=Abstract

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Reye's syndrome: epidemiology and treatment. Author(s): Wright EG. Source: Curr Pract Pediatr Nurs. 1980; 3: 206-21. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6904281&dopt=Abstract

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Reye's syndrome: hold the obituary. Author(s): Sarnaik AP. Source: Critical Care Medicine. 1999 August; 27(8): 1674-6. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10470794&dopt=Abstract

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Reye's syndrome: incidence and time trends in Olmsted County, MN, 1950-1981. Author(s): Nicolosi A, Hauser WA, Kurland LT, Beghi E. Source: Neurology. 1985 September; 35(9): 1338-40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4022381&dopt=Abstract

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Reye's syndrome: isolation of parainfluenza virus. Report of three cases. Author(s): Powell HC, Rosenberg RN, McKellar B. Source: Archives of Neurology. 1973 September; 29(3): 135-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4360417&dopt=Abstract

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Reye's syndrome: lessons for family physicians. Author(s): Baird RE, Foley C, Bresee J, Schonberger LB. Source: American Family Physician. 1994 November 15; 50(7): 1454, 1458, 1460-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7976977&dopt=Abstract

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Reye's syndrome: marked fatty metamorphosis of the liver with encephalopathy. Author(s): Dubilier LD, Chipps HD. Source: J Ky Med Assoc. 1972 September; 70(9): 694-7. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5068928&dopt=Abstract

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Reye's syndrome: massive fatty metamorphosis of the liver with acute encephalopathy. Author(s): Barr R, Glass IH, Chawla GS. Source: Can Med Assoc J. 1968 June 1; 98(22): 1038-44. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5652447&dopt=Abstract

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Reye's syndrome: mitochondrial swelling and Ca2+ release induced by Reye's plasma, allantoin, and salicylate. Author(s): Martens ME, Chang CH, Lee CP. Source: Archives of Biochemistry and Biophysics. 1986 February 1; 244(2): 773-86. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3080954&dopt=Abstract

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Reye's syndrome: much work remains to be done. Author(s): Van Acker KJ. Source: Acta Paediatr Belg. 1976 January-March; 29(1): 9-12. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1015295&dopt=Abstract

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Reye's syndrome: not of historical interest only. Author(s): Valencia AM, Quevedo FW, Quintos LS. Source: The Pediatric Infectious Disease Journal. 1997 October; 16(10): 1011-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9380462&dopt=Abstract

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Reye's syndrome: patient serum alters mitochondrial function and morphology in vitro. Author(s): Aprille JR. Source: Science. 1977 August 26; 197(4306): 908-10. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=887930&dopt=Abstract

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Reye's syndrome: plasma-induced alterations in mitochondrial structure and function. Author(s): Segalman TY, Lee CP. Source: Archives of Biochemistry and Biophysics. 1982 April 1; 214(2): 522-30. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6178367&dopt=Abstract

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Reye's syndrome: preservation of mitochondrial enzymes in brain and muscle compared with liver. Author(s): Robinson BH, Taylor J, Cutz E, Gall DG. Source: Pediatric Research. 1978 November; 12(11): 1045-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=214743&dopt=Abstract

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Reye's syndrome: relapses and neurological sequelae. Author(s): van Caillie M, Morin CL, Roy CC, Geoffroy G, McLaughlin B. Source: Pediatrics. 1977 February; 59(2): 245-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=834507&dopt=Abstract

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Reye's syndrome: relation of outcome to therapy. Author(s): Huttenlocher PR. Source: The Journal of Pediatrics. 1972 May; 80(5): 845-50. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5018398&dopt=Abstract

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Reye's syndrome: report of a case. Author(s): McCarthy DJ, Gillespie DL. Source: Rocky Mt Med J. 1973 May; 70(5): 40-1. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4698478&dopt=Abstract

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Reye's syndrome: report of cases and a review of literature. Author(s): Simmons RE, Reddy JK. Source: J Kans Med Soc. 1975 June; 76(6): 119-24, 128. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1133496&dopt=Abstract

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Reye's syndrome: review and update. Author(s): Maheady DC. Source: Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners. 1989 September-October; 3(5): 246-50. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2674393&dopt=Abstract

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Reye's syndrome: salicylates and mitochondrial functions. Author(s): Martens ME, Lee CP. Source: Biochemical Pharmacology. 1984 September 15; 33(18): 2869-76. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6477646&dopt=Abstract

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Reye's syndrome: success of supportive care. Author(s): Newman SL, Caplan DB, Ahmann PA. Source: The New England Journal of Medicine. 1978 November 9; 299(19): 1079. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=703781&dopt=Abstract

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Reye's syndrome: the effect of patient serum on mitochondrial respiration in vitro. Author(s): Asimakis GK, Aprille JR. Source: Biochemical and Biophysical Research Communications. 1977 December 21; 79(4): 1122-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=603647&dopt=Abstract

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Reye's syndrome: to be or not to be. Author(s): Thaler MM. Source: Gastroenterology. 1979 April; 76(4): 890-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=422019&dopt=Abstract

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Reye's syndrome: twenty years in perspective. Author(s): Riela AR, Roach ES. Source: N C Med J. 1983 June; 44(6): 351-5. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6348559&dopt=Abstract

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Reye's syndrome: when early referral is vital to prevent death. Author(s): Larcher V. Source: Nurs Mirror. 1978 November 23; 147(21): 37-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=251302&dopt=Abstract

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Reye's syndrome:clinical diagnosis and treatment with peritoneal dialysis. Author(s): Samaha FJ, Blau E, Berardinelli JL. Source: Pediatrics. 1974 March; 53(3): 336-40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4815251&dopt=Abstract

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Reye's syndrome; diagnosis by muscle biopsy? Author(s): Shapira Y, Deckelbaum R, Statter M, Tennenbaum A, Aker M, Yarom R. Source: Archives of Disease in Childhood. 1981 April; 56(4): 287-91. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7247440&dopt=Abstract

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Reye's syndrome--1980. Author(s): Dobrin RS. Source: Med Times. 1980 September; 108(9): 1S-3S, 9S-10S, 15S-16S Passim. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7432112&dopt=Abstract

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Reye's syndrome--a case report. Author(s): Johnson BE, Hanchard B. Source: The West Indian Medical Journal. 1979 June; 28(2): 124-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=473763&dopt=Abstract

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Reye's syndrome--a comparison between city and rural cases. A review. Author(s): Angsubhakorn S, Bhamarapravati N, Sirikulchayanonta V, Sahaphong S, Thamavit W. Source: J Med Assoc Thai. 1978 September; 61(9): 521-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=690540&dopt=Abstract

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Reye's syndrome--a continuing enigma. Author(s): Mowat AP. Source: Adverse Drug React Acute Poisoning Rev. 1987 Winter; 6(4): 211-30. Review. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3328492&dopt=Abstract

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Reye's syndrome--a preliminary report on early diagnosis and management. Author(s): Halliday HL, Glasgow JF. Source: Ir Med J. 1977 March 31; 70(4): 112-4. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=852967&dopt=Abstract

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Reye's syndrome--an interesting epidemiological correlation. Author(s): Vashishtha VM, Sharma JP. Source: Indian Pediatrics. 2000 March; 37(3): 343-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10750089&dopt=Abstract

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Reye's syndrome-aspirin link: a bit stronger. Author(s): Check W. Source: Jama : the Journal of the American Medical Association. 1982 March 19; 247(11): 1534-5, 1539. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7062448&dopt=Abstract

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Reye's syndrome--in disguise. Author(s): McEvoy M, Drury MI. Source: Ir J Med Sci. 1982 May; 151(5): 162-4. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6809688&dopt=Abstract

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Reye's syndrome-like illness in a patient receiving amiodarone. Author(s): Jones DB, Mullick FG, Hoofnagle JH, Baranski B. Source: The American Journal of Gastroenterology. 1988 September; 83(9): 967-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3414648&dopt=Abstract

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Reye's syndrome--still an elusive entity. Author(s): Huttenlocher PR. Source: The Western Journal of Medicine. 1984 August; 141(2): 236-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6495728&dopt=Abstract

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S. C. Paul oration 1980. Reye's syndrome and a Reye's syndrome-like illness with early seizures--their pathogenesis and treatment. Author(s): Aiyathurai JE. Source: Ceylon Med J. 1980 March-June; 25(1-2): 5-25. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6965244&dopt=Abstract

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Salicylate and mitochondrial monoamine oxidase function in Reye's syndrome. Author(s): Faraj BA, Caplan D, Lolies P, Buchanan C. Source: Journal of Pharmaceutical Sciences. 1987 June; 76(6): 423-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3625483&dopt=Abstract

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Salicylate and Reye's syndrome. Author(s): Rodgers GC Jr, Weiner LB, McMillan JA. Source: Lancet. 1982 March 13; 1(8272): 616. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6121196&dopt=Abstract

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Salicylate and Reye's syndrome. Author(s): Pascoe JM. Source: Pediatrics. 1981 October; 68(4): 610-1. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7322705&dopt=Abstract

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Salicylates and Reye's syndrome. Author(s): Simmons VP. Source: Jama : the Journal of the American Medical Association. 1983 September 16; 250(11): 1393. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6887457&dopt=Abstract

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Salicylates and Reye's syndrome. Author(s): Tonsgard JH, Huttenlocher PR. Source: Pediatrics. 1981 November; 68(5): 747-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7312481&dopt=Abstract

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Salicylates and Reye's syndrome: epidemiologic data as a basis of action. Author(s): Alexander ER. Source: Jama : the Journal of the American Medical Association. 1982 August 13; 248(6): 722-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7097927&dopt=Abstract

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Salicylates, nitric oxide, malaria, and Reye's syndrome. Author(s): Clark I, Whitten R, Molyneux M, Taylor T. Source: Lancet. 2001 February 24; 357(9256): 625-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11558501&dopt=Abstract

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Salicylates, nitric oxide, malaria, and Reye's syndrome. Author(s): Willcox ML. Source: Lancet. 2001 June 9; 357(9271): 1881-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=11417574&dopt=Abstract

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Scientific uncertainties in the studies of salicylate use and Reye's syndrome. Author(s): Daniels SR, Greenberg RS, Ibrahim MA. Source: Jama : the Journal of the American Medical Association. 1983 March 11; 249(10): 1311-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6827709&dopt=Abstract

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Septicemic plague that mimics Reye's syndrome. Author(s): Washington RL, Barkin RM, Hillman JR. Source: Am J Dis Child. 1979 April; 133(4): 434-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=433859&dopt=Abstract

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Serum carnitine in Reye's syndrome. Author(s): Hinshaw WB Jr, Glenn JL, Hatch KM. Source: The New England Journal of Medicine. 1980 June 19; 302(25): 1423. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7374704&dopt=Abstract

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Serum creatine kinase inhibition in Reye's syndrome. Author(s): Forman DT, Kieffer H, Grayson SH. Source: Clinical Chemistry. 1977 July; 23(7): 1364-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=872393&dopt=Abstract

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Serum enzyme alterations in arginine-deficient, influenza-infected ferrets: a potential animal model of Reye's syndrome. Author(s): Deshmukh DR, Kao W, Mason M, Maassab HF, Baublis JV. Source: Enzyme. 1982; 27(1): 52-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7067689&dopt=Abstract

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Serum glutamate dehydrogenase and ornithine carbamyl transferase in Reye's syndrome. Author(s): Deshmukh DR, Thomas PE, McArthur B, Sarnaik AP. Source: Enzyme. 1985; 33(3): 171-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4054075&dopt=Abstract

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Serum isocitrate dehydrogenase activity in Reye's syndrome. Author(s): Deshmukh DR, Shope TC, Sarnaik AP. Source: Biochemical Medicine and Metabolic Biology. 1987 April; 37(2): 255-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3593596&dopt=Abstract

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Serum lipolytic activity in Reye's syndrome. Author(s): Kang ES, Matsuo N, Nagai T, Greenhaw J, Williams PL. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1989 September 15; 184(1): 107-14. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2598464&dopt=Abstract

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Serum ornithine carbamyl transferase activities in Reye's syndrome. Author(s): Deshmukh DR, Rittenhouse JW, Mason M, Baublis JV. Source: Enzyme. 1982; 27(1): 45-51. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7067688&dopt=Abstract

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Serum uric acid as a prognostic indicator in Reye's syndrome? Author(s): Bhuvaneswaran C, Brewster MA. Source: Biochem Med. 1980 December; 24(3): 361-3. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7283990&dopt=Abstract

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Short-chain fatty acids and encephalopathy of Reye's syndrome. Author(s): McArthur B, Sarnaik AP, Mitchell RA. Source: Neurology. 1984 June; 34(6): 831-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6539450&dopt=Abstract

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Short-chain organic acidemia and Reye's syndrome. Author(s): Trauner DA, Nyhan WL, Sweetman L. Source: Neurology. 1975 March; 25(3): 296-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1167641&dopt=Abstract

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Simulated Reye's syndrome and salicylate therapy. Author(s): Yoshida I, Yamashita F, Okada S, Horikoshi T. Source: Acta Paediatr Scand. 1984 July; 73(4): 562-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6464745&dopt=Abstract

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Social class and age distribution in Reye's syndrome. Author(s): Morris JA, Shapiro DZ. Source: British Medical Journal (Clinical Research Ed.). 1986 February 8; 292(6517): 379. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3080182&dopt=Abstract

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Spotting Reye's syndrome while there's still time. Author(s): Budd RA, Rothwell R. Source: Rn. 1983 December; 46(12): 38-42, 67. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6560752&dopt=Abstract

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Standardized care plan for a child with Reye's syndrome. Author(s): Slota MC. Source: Critical Care Nurse. 1984 January-February; 4(1): 100-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6559648&dopt=Abstract

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Studies on the pathophysiology of encephalopathy in Reye's syndrome; Hyperammonemia in Reye's syndrome. Author(s): Shannon DC, De Long R, Bercu B, Glick T, Herrin JT, Moylan FM, Todres ID. Source: Pediatrics. 1975 December; 56(6): 999-1004. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1196768&dopt=Abstract

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Systemic carnitine deficiency--a treatable inherited lipid-storage disease presenting as Reye's syndrome. Author(s): Chapoy PR, Angelini C, Brown WJ, Stiff JE, Shug AL, Cederbaum SD. Source: The New England Journal of Medicine. 1980 December 11; 303(24): 1389-94. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7432384&dopt=Abstract

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Take two aspirin and call me in the morning. Salicylate use and Reye's syndrome. Author(s): Hoekelman RA. Source: Am J Dis Child. 1982 November; 136(11): 973-4. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7124702&dopt=Abstract

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Teaching parents about Reye's syndrome. Author(s): Martelli ME. Source: The American Journal of Nursing. 1982 February; 82(2): 260-3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6915709&dopt=Abstract

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Temperature, mitochondria, and Reye's syndrome. Author(s): El-Mallakh RS. Source: Pediatrics. 1983 June; 71(6): 985-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6856417&dopt=Abstract

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The biochemistry of Reye's syndrome. Author(s): Brown RE, Forman DT. Source: Critical Reviews in Clinical Laboratory Sciences. 1982; 17(3): 247-97. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6127187&dopt=Abstract

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The changing age distribution of Reye's syndrome in the United States and a critique of the CDC criteria. Author(s): Yoshida I, Yamashita F. Source: Acta Paediatr Jpn. 1990 August; 32(4): 378-80. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1963024&dopt=Abstract

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The changing clinical pattern of Reye's syndrome 1982-1990. Author(s): Hardie RM, Newton LH, Bruce JC, Glasgow JF, Mowat AP, Stephenson JB, Hall SM. Source: Archives of Disease in Childhood. 1996 May; 74(5): 400-5. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=8669954&dopt=Abstract

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The changing clinical pattern of Reye's syndrome 1982-90. Author(s): Casteels-Van Daele M, Van Geet C, Wouters K, Eggermont E. Source: Archives of Disease in Childhood. 1997 January; 76(1): 79. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9059171&dopt=Abstract

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The changing epidemiology of Reye's syndrome in the United States: further evidence for a public health success. Author(s): Hurwitz ES. Source: Jama : the Journal of the American Medical Association. 1988 December 2; 260(21): 3178-80. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3184397&dopt=Abstract

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The changing face of Reye's Syndrome. Author(s): Breheny FX, O'Brien TA, Monaghen H, Wren WS. Source: Ir Med J. 1982 March; 75(3): 72-3. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7076469&dopt=Abstract

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The choroid plexus in Reye's syndrome. Author(s): Brown RE, Madge GE. Source: Va Med Mon (1918). 1972 March; 99(3): 271-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5025843&dopt=Abstract

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The coagulation defect in Reye's syndrome. Author(s): Schwartz AD. Source: The Journal of Pediatrics. 1971 February; 78(2): 326-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5539781&dopt=Abstract

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The diagnosis and management of Reye's syndrome. Author(s): Kearney PJ, Deasy PF, O'Donohoe NV. Source: Ir Med J. 1975 April 12; 68(7): 169-74. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1132960&dopt=Abstract

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The diagnosis and treatment of Reye's syndrome. Author(s): Drage JS. Source: Indian J Pediatr. 1981 September-October; 48(394): 569-74. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7327649&dopt=Abstract

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The disappearance of Reye's syndrome--a public health triumph. Author(s): Monto AS. Source: The New England Journal of Medicine. 1999 May 6; 340(18): 1423-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10228195&dopt=Abstract

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The first case of H5N1 avian influenza infection in a human with complications of adult respiratory distress syndrome and Reye's syndrome. Author(s): Ku AS, Chan LT. Source: Journal of Paediatrics and Child Health. 1999 April; 35(2): 207-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10365363&dopt=Abstract

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The hepatic lesion in Reye's syndrome. Author(s): Bove KE, McAdams AJ, Partin JC, Partin JS, Hug G, Schubert WK. Source: Gastroenterology. 1975 September; 69(3): 685-97. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1158086&dopt=Abstract

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The interval between varicella and Reye's syndrome. Author(s): Glasgow AM, Gold MB. Source: Am J Dis Child. 1979 June; 133(6): 653. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=443225&dopt=Abstract

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The isoprenoid pathway and the pathogenesis of Reye's syndrome. Author(s): Kurup RK, Kurup PA. Source: Pediatric Pathology & Molecular Medicine. 2003 March-April; 22(2): 159-70. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=12556296&dopt=Abstract

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The mechanism of inhibition of beta-oxidation by aspirin metabolites in skin fibroblasts from Reye's syndrome patients and controls. Author(s): Glasgow JF, Middleton B, Moore R, Gray A, Hill J. Source: Biochimica Et Biophysica Acta. 1999 May 31; 1454(1): 115-25. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10354521&dopt=Abstract

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The metabolic course of Reye's syndrome: distinction between survivors and nonsurvivors. Author(s): Arcinue EL, Mitchell RA, Sarnaik AP, McArthur B. Source: Neurology. 1986 March; 36(3): 435-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3951718&dopt=Abstract

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The metabolic effects of aspirin in fasting and fed subjects: relevance to the aetiology of Reye's syndrome. Author(s): Williams FM, Ferner RE, Graham M, Blain PG, Alberti KG, Rawlins MD. Source: European Journal of Clinical Pharmacology. 1990; 38(5): 519-21. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2379539&dopt=Abstract

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The neuron-specific enolase as a marker of brain destruction in a case of Reye's syndrome: related to the treatment of brain edema. Author(s): Nara T, Tsukiyama T, Nishimoto H. Source: Acta Paediatr Scand. 1988 November; 77(6): 912-3. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3207025&dopt=Abstract

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The probable mechanisms of brain damage and epilepsy in febrile convulsions, Singapore syndrome and Reye's syndrome. Author(s): Aiyathurai EJ, Boon WH. Source: Acta Paediatr Jpn. 1989 June; 31(3): 245-58. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2508420&dopt=Abstract

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The prognosis of Reye's syndrome in Ireland. Can it be improved. Author(s): Glasgow JF, Jenkins JG, Hicks EM, Keilty SR, Crean PM, Black GW, Fannin TF. Source: Ir J Med Sci. 1986 April; 155(4): 111-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3721815&dopt=Abstract

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The proportion of mitochondrial isoenzyme of aspartate aminotransferase is not elevated in Reye's syndrome. Author(s): Mock DM, Scott M, Mock NI, Thaler MM. Source: Pediatric Research. 1983 November; 17(11): 884-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6646898&dopt=Abstract

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The significance of serum triglyceride changes in viral ketoacidosis and Reye's syndrome. Author(s): Aiyathurai JE, Sentheshanmuganathan S, Parameshwaran N. Source: J Singapore Paediatr Soc. 1986; 28(3-4): 237-42. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3599930&dopt=Abstract

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The truths and myths about Reye's syndrome. Author(s): Bhagwat AG. Source: Indian J Pathol Bacteriol. 1974 July; 17(3): 143-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4455624&dopt=Abstract

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The use of citrulline for the treatment of Reye's syndrome: case reports. Author(s): Oetgen WJ. Source: Military Medicine. 1977 February; 142(2): 162-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=401969&dopt=Abstract

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The use of lactulose syrup for the control of hyperammonemia in Reye's syndrome: report of case. Author(s): Smith VS, Mikesell D, Stoker JA. Source: J Am Osteopath Assoc. 1978 October; 78(2): 126-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=711525&dopt=Abstract

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The viral mechanism of Reye's syndrome. Author(s): Younkin B, Gudzinowicz B. Source: Medical Hypotheses. 1984 June; 14(2): 161-80. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6379395&dopt=Abstract

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Therapeutic considerations in Reye's syndrome. Author(s): Brown RE, Madge GE. Source: Pediatrics. 1971 July; 48(1): 162-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5561873&dopt=Abstract

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Therapeutic delirium in Reye's syndrome. Author(s): Nadler H. Source: Pediatrics. 1974 September; 54(3): 265-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4416626&dopt=Abstract

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Therapy of Reye's syndrome. Author(s): Eskes PW. Source: Pediatrics. 1972 January; 49(1): 153-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5059304&dopt=Abstract

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Therapy of Reye's syndrome. Author(s): Haller JS. Source: Am J Hosp Pharm. 1979 December; 36(12): 1654, 1657-8. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=525639&dopt=Abstract

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Thiopental sodium and pentobarbital sodium in the treatment of Reye's syndrome. Author(s): Treadwell BE. Source: Am J Hosp Pharm. 1979 November; 36(11): 1480. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=517530&dopt=Abstract

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Total alpha-amino acid nitrogen quantification as prognosticator in Reye's syndrome. Author(s): McArthur BS, Arcinue EL, Schultz GE. Source: Am J Dis Child. 1981 August; 135(8): 765-6. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7270523&dopt=Abstract

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Total blood washout and exchange. A valuable tool in acute hepatic coma and Reye's syndrome. Author(s): Cooper GN Jr, Karlson KE, Clowes GH, Martin H, Randall HT. Source: American Journal of Surgery. 1977 April; 133(4): 522-30. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=848687&dopt=Abstract

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Total blood washout for Reye's syndrome. Author(s): Talmage EA, Thomas JM, Weeks JH. Source: Anesthesia and Analgesia. 1973 July-August; 52(4): 563-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4736854&dopt=Abstract

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Transient intellectual and psychosocial regression during recovery phase of stage V Reye's syndrome. Author(s): Preston G, Sarnaik AP, Nigro M. Source: Journal of Developmental and Behavioral Pediatrics : Jdbp. 1982 December; 3(4): 206-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7153366&dopt=Abstract

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Transiently reduced activity of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of children with Reye's syndrome. Author(s): Brown T, Hug G, Lansky L, Bove K, Scheve A, Ryan M, Brown H, Schubert WK, Partin JC, Lloyd-Still J. Source: The New England Journal of Medicine. 1976 April 15; 294(16): 861-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=175276&dopt=Abstract

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Transplantation of organs from donors with Reye's syndrome: is it safe? Author(s): Sumrani N, Delaney V, Hong JH, Lipkowitz GS, Butt KM. Source: American Journal of Nephrology. 1990; 10(1): 87-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2343884&dopt=Abstract

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Treatment of Reye's syndrome at Sumber Waras Hospital. Author(s): Wulur H, Kho LK. Source: Acta Paediatr Jpn. 1990 August; 32(4): 435-42. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2126907&dopt=Abstract

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Trends in the incidence of Reye's syndrome and the use of aspirin. Author(s): Porter JD, Robinson PH, Glasgow JF, Banks JH, Hall SM. Source: Archives of Disease in Childhood. 1990 August; 65(8): 826-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2400216&dopt=Abstract

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Two autopsy cases of Reye's syndrome. Author(s): Motoi M, Kobayashi S, Ogawa K, Murakami M, Aoyama K. Source: Acta Pathol Jpn. 1970 May; 20(2): 251-9. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5536774&dopt=Abstract

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Ultrasonically undetectable fatty liver in acute fatty liver of pregnancy and Reye's syndrome. Author(s): Shimizu M, Okumura M, Yuh K, Oita J, Shimizu H. Source: Journal of Clinical Ultrasound : Jcu. 1985 November-December; 13(9): 679-82. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3935687&dopt=Abstract

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Ultrastructural abnormalities of liver cells in Reye's syndrome. Author(s): Iancu TC, Mason WH, Neustein HB. Source: Human Pathology. 1977 July; 8(4): 421-31. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=892794&dopt=Abstract

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Ultrastructural alterations of the lymphocytes from a patient with Reye's syndrome. Author(s): Lewinski UH, Djaldetti M. Source: J Submicrosc Cytol. 1981 October; 13(4): 697-701. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6278162&dopt=Abstract

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Ultrastructural lesions of muscle and immunofluorescent deposits in vessels in Reye's syndrome: a preliminary report of serial muscle biopsies. Author(s): Hanson PA, Urizar RE. Source: Annals of Neurology. 1977 May; 1(5): 431-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=363044&dopt=Abstract

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Ultrastructural study of intranuclear inclusions in the exocrine pancreas in Reye's syndrome. Author(s): Collins DN. Source: Laboratory Investigation; a Journal of Technical Methods and Pathology. 1974 March; 30(3): 333-40. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4817827&dopt=Abstract

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Unusual cerebral inclusions in Reye's syndrome. Author(s): Lantos PL, Anthony PP, Clarke GR. Source: British Medical Journal. 1976 November 13; 2(6045): 1176. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=186150&dopt=Abstract

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Urea-cycle enzyme deficiencies and an increased nitrogen load producing hyperammonemia in Reye's syndrome. Author(s): Snodgrass PJ, DeLong GR. Source: The New England Journal of Medicine. 1976 April 15; 294(16): 855-60. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1250313&dopt=Abstract

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Urinary C6-C12 dicarboxylic acylcarnitines in Reye's syndrome. Author(s): Tracey BM, Cheng KN, Rosankiewicz J, Stacey TE, Chalmers RA. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1988 June 30; 175(1): 79-87. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3168285&dopt=Abstract

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Urinary organic acid profiles of Reye's syndrome patients. Author(s): Harrington W, Liu AS, Lonsdale D, Igou D. Source: Clinica Chimica Acta; International Journal of Clinical Chemistry. 1977 February 1; 74(3): 247-54. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=832426&dopt=Abstract

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Use of aspirin and Reye's syndrome. Author(s): Banco L. Source: Am J Dis Child. 1987 March; 141(3): 240-1. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3812398&dopt=Abstract

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Valueless treatment of Reye's syndrome. Author(s): Stoddart JG. Source: Br J Hosp Med. 1986 January; 35(1): 64-5. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3955292&dopt=Abstract

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Variations in glycerol kinetics in Reye's syndrome. Author(s): Nahata MC, Kerzner B, McClung HJ, Sherard ES, Hilty MD. Source: Clinical Pharmacology and Therapeutics. 1981 June; 29(6): 782-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=7226710&dopt=Abstract

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Varicella hepatitis and Reye's syndrome: an interrelationship? Author(s): Landay SE. Source: Pediatrics. 1977 November; 60(5): 746-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=917641&dopt=Abstract

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Varicella hepatitis or post-varicella Reye's syndrome? Author(s): Guerin JM, Lustman C, Barbotin-Larrieu F. Source: The American Journal of Medicine. 1990 December; 89(6): 836-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2252059&dopt=Abstract

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Viral hepatitis and salicylism simulating Reye's syndrome. Author(s): Lyon LJ, Nevins MA. Source: J Med Soc N J. 1974 September; 71(9): 657-60. No Abstract Available. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4528107&dopt=Abstract

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Visual evoked potentials in Reye's syndrome. Author(s): Ch'ien L, Belluomini J, Lemmi H. Source: Clin Electroencephalogr. 1979 July; 10(3): 164-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=476968&dopt=Abstract

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Vitamin K in Reye's syndrome. Author(s): Bood DJ, Poley JR, Smith JD, Schwartz AD. Source: The Journal of Pediatrics. 1971 October; 79(4): 709-10. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=5094269&dopt=Abstract

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Vitamin K, hepatic fatty infiltration, and Reye's syndrome. Author(s): Boon DJ, Eveloff AR, Pilapil VR. Source: Pediatrics. 1973 January; 51(1): 153-4. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=4684443&dopt=Abstract

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Vocal cord paralysis and superior laryngeal nerve dysfunction in Reye's syndrome. Author(s): Thompson JW, Rosenthal P, Camilon FS Jr. Source: Archives of Otolaryngology--Head & Neck Surgery. 1990 January; 116(1): 46-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2294940&dopt=Abstract

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What every ICU nurse should know about Reye's syndrome. Author(s): Weeks HL. Source: Mcn. the American Journal of Maternal Child Nursing. 1976 July-August; 1(4): 231-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=818464&dopt=Abstract

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Whatever happened to Reye's syndrome? Did it ever really exist? Author(s): Orlowski JP. Source: Critical Care Medicine. 1999 August; 27(8): 1582-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=10470768&dopt=Abstract

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CHAPTER 2. NUTRITION AND REYE’S SYNDROME Overview In this chapter, we will show you how to find studies dedicated specifically to nutrition and Reye’s syndrome.

Finding Nutrition Studies on Reye’s Syndrome The National Institutes of Health’s Office of Dietary Supplements (ODS) offers a searchable bibliographic database called the IBIDS (International Bibliographic Information on Dietary Supplements; National Institutes of Health, Building 31, Room 1B29, 31 Center Drive, MSC 2086, Bethesda, Maryland 20892-2086, Tel: 301-435-2920, Fax: 301-480-1845, E-mail: [email protected]). The IBIDS contains over 460,000 scientific citations and summaries about dietary supplements and nutrition as well as references to published international, scientific literature on dietary supplements such as vitamins, minerals, and botanicals.7 The IBIDS includes references and citations to both human and animal research studies. As a service of the ODS, access to the IBIDS database is available free of charge at the following Web address: http://ods.od.nih.gov/databases/ibids.html. After entering the search area, you have three choices: (1) IBIDS Consumer Database, (2) Full IBIDS Database, or (3) Peer Reviewed Citations Only. Now that you have selected a database, click on the “Advanced” tab. An advanced search allows you to retrieve up to 100 fully explained references in a comprehensive format. Type “Reye’s syndrome” (or synonyms) into the search box, and click “Go.” To narrow the search, you can also select the “Title” field.

7

Adapted from http://ods.od.nih.gov. IBIDS is produced by the Office of Dietary Supplements (ODS) at the National Institutes of Health to assist the public, healthcare providers, educators, and researchers in locating credible, scientific information on dietary supplements. IBIDS was developed and will be maintained through an interagency partnership with the Food and Nutrition Information Center of the National Agricultural Library, U.S. Department of Agriculture.

94 Reye’s Syndrome

The following information is typical of that found when using the “Full IBIDS Database” to search for “Reye’s syndrome” (or a synonym): •

Alterations in plasma amino acids and hepatic enzymes in the 4-pentenoic acid model of Reye's syndrome. Author(s): Department of Chemistry, University of Detroit, MI 48221-9987. Source: Hart, M A Swisher, J A Caspers, M L Biochem-Pharmacol. 1989 May 15; 38(10): 1696-8 0006-2952

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Carnitine metabolism and urinary organic acid excretion in Reye's syndrome and salicylate intoxication. Author(s): Department of Pediatrics, Chiba University School of Medicine, Japan. Source: Takayanagi, M Kakinuma, H Yamamoto, S Nakajima, H Acta-Paediatr-Jpn. 1990 August; 32(4): 406-9 0374-5600

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Depression of oxidative metabolism of aspirin in mice via an interferon-associated mechanism in relation to Reye's syndrome. Source: Dolphin, C T Caldwell, J Smith, R L J-Pharm-Pharmacol. 1987 March; 39(3): 22830 0022-3573

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Effects of peroxidized polyunsaturated fatty acids on mitochondrial function and structure: pathogenetic implications for Reye's syndrome. Author(s): Department of Pathology, Cook-Fort Worth Children's Medical Center, TX 76104. Source: Brown, R E Bhuvaneswaran, C Brewster, M Ann-Clin-Lab-Sci. 1988 Jul-August; 18(4): 337-43 0091-7370

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Erythrocyte lipid abnormalities in Reye's syndrome. Source: Schwarz, K B Larroya, S Kohlman, L Morrison, A Pediatr-Res. 1987 April; 21(4): 352-6 0031-3998

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Evaluation of the possible role of glucose, carnitine, coenzyme Q10 and steroids in the treatment of Reye's syndrome using the margosa oil animal model. Author(s): Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur. Source: Sinniah, D Sinniah, R Baskaran, G Pathmanathan, R Yamashita, F Yoshino, M Acta-Paediatr-Jpn. 1990 August; 32(4): 462-8 0374-5600

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Impaired oxidative metabolism of salicylate in Reye's syndrome. Author(s): Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit. Source: Meert, K L Kauffman, R E Deshmukh, D R Sarnaik, A P Dev-Pharmacol-Ther. 1990; 15(2): 57-60 0379-8305

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Inhibition of fatty acid beta oxidation by influenza B virus and salicylic acid in mice: implications for Reye's syndrome. Author(s): Department of Neurosciences, UCSD Medical Center 92103. Source: Trauner, D A Horvath, E Davis, L E Neurology. 1988 February; 38(2): 239-41 0028-3878

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Inhibition of mitochondrial functions by margosa oil: possible implications in the pathogenesis of Reye's syndrome. Author(s): Department of Pediatrics and Child Health, Kurume University School of Medicine, Malaya. Source: Koga, Y Yoshida, I Kimura, A Yoshino, M Yamashita, F Sinniah, D Pediatr-Res. 1987 August; 22(2): 184-7 0031-3998

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Interactions of ibuprofen with influenza infection and hyperammonemia in an animal model of Reye's syndrome. Author(s): Department of Pediatrics, Children's Hospital of Michigan, Detroit 48201. Source: Mukhopadhyay, A Sarnaik, A P Deshmukh, D R Pediatr-Res. 1992 March; 31(3): 258-60 0031-3998

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Microvesicular fatty liver in rats with resembling Reye's syndrome induced by 4pentenoic acid. Author(s): Department of Pathology, Kansai Medical University, Osaka, Japan. Source: Sakaida, N Senzaki, H Shikata, N Morii, S Acta-Pathol-Jpn. 1990 September; 40(9): 635-42 0001-6632

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Octanoic acid inhibits astrocyte volume control: implications for cerebral edema in Reye's syndrome. Author(s): Department of Emergency Medicine, Wright State University, School of Medicine, Dayton, Ohio 45401. Source: Olson, J E Holtzman, D Sankar, R Lawson, C Rosenberg, R J-Neurochem. 1989 April; 52(4): 1197-202 0022-3042

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On octanoic acid-induced hyperventilation--implications for hepatic encephalopathy and Reye's syndrome. Author(s): Department of Pathophysiology, Faculty of Medicine, Higher Medical Institute, Plovdiv, Bulgaria. Source: Mitkov, D Toreva, D Krustev, A Kostadinova, I Jumbasova, S Res-Exp-Med(Berl). 1989; 189(5): 347-54 0300-9130

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Response of epithelial cells of the choroid plexus in the ferret model for Reye's syndrome. Source: Rarey, K E Davis, J A Deshmukh, D R Lab-Invest. 1987 March; 56(3): 249-55 0023-6837

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The mechanism of inhibition of beta-oxidation by aspirin metabolites in skin fibroblasts from Reye's syndrome patients and controls. Author(s): Nuffield Department of Child Health, The Queen's University of Belfast, Royal Belfast Hospital for Sick Children, Belfast BT12 6BA, UK. Source: Glasgow, J F Middleton, B Moore, R Gray, A Hill, J Biochim-Biophys-Acta. 1999 May 31; 1454(1): 115-25 0006-3002

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The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury. Author(s): Department of Cell Biology & Anatomy, School of Medicine, University of North Carolina at Chapel Hill, USA. Source: Trost, L C Lemasters, J J J-Pharmacol-Exp-Ther. 1996 September; 278(3): 1000-5 0022-3565

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Urinary C6-C12 dicarboxylic acylcarnitines in Reye's syndrome. Author(s): Perinatal and Child Health, MRC Clinical Research Centre, Harrow, Middlesex, UK. Source: Tracey, B M Cheng, K N Rosankiewicz, J Stacey, T E Chalmers, R A Clin-ChimActa. 1988 June 30; 175(1): 79-87 0009-8981

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Federal Resources on Nutrition In addition to the IBIDS, the United States Department of Health and Human Services (HHS) and the United States Department of Agriculture (USDA) provide many sources of information on general nutrition and health. Recommended resources include: •

healthfinder®, HHS’s gateway to health information, including diet and nutrition: http://www.healthfinder.gov/scripts/SearchContext.asp?topic=238&page=0

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The United States Department of Agriculture’s Web site dedicated to nutrition information: www.nutrition.gov

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The Food and Drug Administration’s Web site for federal food safety information: www.foodsafety.gov

•

The National Action Plan on Overweight and Obesity sponsored by the United States Surgeon General: http://www.surgeongeneral.gov/topics/obesity/

•

The Center for Food Safety and Applied Nutrition has an Internet site sponsored by the Food and Drug Administration and the Department of Health and Human Services: http://vm.cfsan.fda.gov/

•

Center for Nutrition Policy and Promotion sponsored by the United States Department of Agriculture: http://www.usda.gov/cnpp/

•

Food and Nutrition Information Center, National Agricultural Library sponsored by the United States Department of Agriculture: http://www.nal.usda.gov/fnic/

•

Food and Nutrition Service sponsored by the United States Department of Agriculture: http://www.fns.usda.gov/fns/

Additional Web Resources A number of additional Web sites offer encyclopedic information covering food and nutrition. The following is a representative sample: •

AOL: http://search.aol.com/cat.adp?id=174&layer=&from=subcats

•

Family Village: http://www.familyvillage.wisc.edu/med_nutrition.html

•

Google: http://directory.google.com/Top/Health/Nutrition/

•

Healthnotes: http://www.healthnotes.com/

•

Open Directory Project: http://dmoz.org/Health/Nutrition/

•

Yahoo.com: http://dir.yahoo.com/Health/Nutrition/

•

WebMDHealth: http://my.webmd.com/nutrition

•

WholeHealthMD.com: http://www.wholehealthmd.com/reflib/0,1529,,00.html

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CHAPTER 3. SYNDROME

ALTERNATIVE MEDICINE AND REYE’S

Overview In this chapter, we will begin by introducing you to official information sources on complementary and alternative medicine (CAM) relating to Reye’s syndrome. At the conclusion of this chapter, we will provide additional sources.

National Center for Complementary and Alternative Medicine The National Center for Complementary and Alternative Medicine (NCCAM) of the National Institutes of Health (http://nccam.nih.gov/) has created a link to the National Library of Medicine’s databases to facilitate research for articles that specifically relate to Reye’s syndrome and complementary medicine. To search the database, go to the following Web site: http://www.nlm.nih.gov/nccam/camonpubmed.html. Select “CAM on PubMed.” Enter “Reye’s syndrome” (or synonyms) into the search box. Click “Go.” The following references provide information on particular aspects of complementary and alternative medicine that are related to Reye’s syndrome: •

Chronic camphor ingestion mimicking Reye's syndrome. Author(s): Jimenez JF, Brown AL, Arnold WC, Byrne WJ. Source: Gastroenterology. 1983 February; 84(2): 394-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6848413&dopt=Abstract

•

Control of polyunsaturated acids in tissue lipids. Author(s): Holman RT. Source: Journal of the American College of Nutrition. 1986; 5(2): 183-211. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2873160&dopt=Abstract

•

Manslaughter by heat stroke. Medical comment. Author(s): McCloskey BP.

98 Reye’s Syndrome

Source: The Medical Journal of Australia. 1976 December 18-25; 2(25-26): 925-6. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=1018673&dopt=Abstract •

Margosa oil poisoning as a cause of Reye's syndrome. Author(s): Sinniah D, Baskaran G. Source: Lancet. 1981 February 28; 1(8218): 487-9. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6110100&dopt=Abstract

•

Plague pneumonia disease caused by Yersinia pestis. Author(s): Cleri DJ, Vernaleo JR, Lombardi LJ, Rabbat MS, Mathew A, Marton R, Reyelt MC. Source: Seminars in Respiratory Infections. 1997 March; 12(1): 12-23. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=9097371&dopt=Abstract

•

Pyrrolizidine (Senecio) intoxication mimicking Reye syndrome. Author(s): Fox DW, Hart MC, Bergeson PS, Jarrett PB, Stillman AE, Huxtable RJ. Source: The Journal of Pediatrics. 1978 December; 93(6): 980-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=722447&dopt=Abstract

•

Reye's syndrome and spruce budworm insecticide spraying in Maine, 1978-1982. Author(s): Wood RB Jr, Bogdan GF. Source: American Journal of Epidemiology. 1986 October; 124(4): 671-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=3752060&dopt=Abstract

•

Significance of positive spike burst in Reye syndrome. Author(s): Yamada T, Young S, Kimura J. Source: Archives of Neurology. 1977 June; 34(6): 376-80. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=871261&dopt=Abstract

•

Systemic carnitine deficiency: benefit of oral carnitine supplements vs. persisting biochemical abnormalities. Author(s): Duran M, de Klerk JB, Wadman SK, Scholte HR, Beekman RP, Jennekens FG. Source: European Journal of Pediatrics. 1984 August; 142(3): 224-8. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=6468448&dopt=Abstract

•

The clinical syndrome of Impila (Callilepis laureola) poisoning in children. Author(s): Watson AR, Coovadia HM, Bhoola KD. Source: South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 1979 February 24; 55(8): 290-2. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=441880&dopt=Abstract

Alternative Medicine 99

•

The effect of L-carnitine supplementation in 4 pentenoic acid treated rats. Author(s): Sugimoto T, Woo M, Nishida N, Araki A, Murakami K, Kobayashi Y. Source: Brain & Development. 1990; 12(4): 417-22. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ uids=2240462&dopt=Abstract

Additional Web Resources A number of additional Web sites offer encyclopedic information covering CAM and related topics. The following is a representative sample: •

Alternative Medicine Foundation, Inc.: http://www.herbmed.org/

•

AOL: http://search.aol.com/cat.adp?id=169&layer=&from=subcats

•

Chinese Medicine: http://www.newcenturynutrition.com/

•

drkoop.com: http://www.drkoop.com/InteractiveMedicine/IndexC.html

•

Family Village: http://www.familyvillage.wisc.edu/med_altn.htm

•

Google: http://directory.google.com/Top/Health/Alternative/

•

Healthnotes: http://www.healthnotes.com/

•

MedWebPlus: http://medwebplus.com/subject/Alternative_and_Complementary_Medicine

•

Open Directory Project: http://dmoz.org/Health/Alternative/

•

HealthGate: http://www.tnp.com/

•

WebMDHealth: http://my.webmd.com/drugs_and_herbs

•

WholeHealthMD.com: http://www.wholehealthmd.com/reflib/0,1529,,00.html

•

Yahoo.com: http://dir.yahoo.com/Health/Alternative_Medicine/

The following is a specific Web list relating to Reye’s syndrome; please note that any particular subject below may indicate either a therapeutic use, or a contraindication (potential danger), and does not reflect an official recommendation (some Web sites are subscription based): •

General Overview Epstein-Barr Virus Source: Integrative Medicine Communications; www.drkoop.com Fever of Unknown Origin Source: Integrative Medicine Communications; www.drkoop.com Flu Source: Integrative Medicine Communications; www.drkoop.com

100 Reye’s Syndrome

Influenza Source: Healthnotes, Inc. www.healthnotes.com Influenza Source: Integrative Medicine Communications; www.drkoop.com Insect Bites and Stings Source: Integrative Medicine Communications; www.drkoop.com Mononucleosis Source: Integrative Medicine Communications; www.drkoop.com Recurrent Ear Infections Source: Healthnotes, Inc. www.healthnotes.com Roseola Source: Integrative Medicine Communications; www.drkoop.com Rubella Source: Integrative Medicine Communications; www.drkoop.com •

Herbs and Supplements Aspirin Source: Healthnotes, Inc. www.healthnotes.com Glutamine Source: Integrative Medicine Communications; www.drkoop.com Meadowsweet Alternative names: Filipendula ulmaria Source: Healthnotes, Inc. www.healthnotes.com White Willow Source: Prima Communications, Inc.www.personalhealthzone.com White willow bark Source: WholeHealthMD.com, LLC. www.wholehealthmd.com Hyperlink: http://www.wholehealthmd.com/refshelf/substances_view/0,1525,10069,00.html Willow Alternative names: Salix alba Source: Healthnotes, Inc. www.healthnotes.com Willow Bark Alternative names: There are several species of willow includingSalix alba, Salix nigra, Salix fragilis, Salix purpurea, Salix babylonica, White Willow, European Willow, Black Willow, Pussy Willow, Crack Willow, Purple Willow, Weeping Willow, Liu-zhi Source: Integrative Medicine Communications; www.drkoop.com

Alternative Medicine 101

General References A good place to find general background information on CAM is the National Library of Medicine. It has prepared within the MEDLINEplus system an information topic page dedicated to complementary and alternative medicine. To access this page, go to the MEDLINEplus site at http://www.nlm.nih.gov/medlineplus/alternativemedicine.html. This Web site provides a general overview of various topics and can lead to a number of general sources.

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CHAPTER 4. BOOKS ON REYE’S SYNDROME Overview This chapter provides bibliographic book references relating to Reye’s syndrome. In addition to online booksellers such as www.amazon.com and www.bn.com, excellent sources for book titles on Reye’s syndrome include the Combined Health Information Database and the National Library of Medicine. Your local medical library also may have these titles available for loan.

Book Summaries: Online Booksellers Commercial Internet-based booksellers, such as Amazon.com and Barnes&Noble.com, offer summaries which have been supplied by each title’s publisher. Some summaries also include customer reviews. Your local bookseller may have access to in-house and commercial databases that index all published books (e.g. Books in Print). IMPORTANT NOTE: Online booksellers typically produce search results for medical and non-medical books. When searching for “Reye’s syndrome” at online booksellers’ Web sites, you may discover non-medical books that use the generic term “Reye’s syndrome” (or a synonym) in their titles. The following is indicative of the results you might find when searching for “Reye’s syndrome” (sorted alphabetically by title; follow the hyperlink to view more details at Amazon.com): •

Reye's syndrome : proceedings of the Reye's Syndrome Conference; ISBN: 0808908871; http://www.amazon.com/exec/obidos/ASIN/0808908871/icongroupinterna

•

Reye's syndrome II : proceedings of the International Conference on Reye's Syndrome, Halifax, Nova Scotia, Canada, June, 1978; ISBN: 0808911783; http://www.amazon.com/exec/obidos/ASIN/0808911783/icongroupinterna

•

The Official Parent's Sourcebook on Reye's Syndrome: A Revised and Updated Directory for the Internet Age by Icon Health Publications; ISBN: 0597830398; http://www.amazon.com/exec/obidos/ASIN/0597830398/icongroupinterna

104 Reye’s Syndrome

The National Library of Medicine Book Index The National Library of Medicine at the National Institutes of Health has a massive database of books published on healthcare and biomedicine. Go to the following Internet site, http://locatorplus.gov/, and then select “Search LOCATORplus.” Once you are in the search area, simply type “Reye’s syndrome” (or synonyms) into the search box, and select “books only.” From there, results can be sorted by publication date, author, or relevance. The following was recently catalogued by the National Library of Medicine:8 •

Reye's syndrome Author: Trauner, Doris A. (Doris Ann),; Year: 1982; Chicago: Year Book Medical Publishers, 1982; ISBN: 0815199058 http://www.amazon.com/exec/obidos/ASIN/0815199058/icongroupinterna

•

Reye's syndrome: hearings before the Subcommittee on Natural Resources, Agriculture Research and Environment of the Committee on Science and Technology, U.S. House of Representatives, Ninety-seventh Congress, second session, September 17 and 29, 1982. Author: United States. Congress. House. Committee on Science and Technology. Subcommittee on Natural Resources, Agriculture Research, and Environment.; Year: 1983; Washington: U.S. G.P.O., 1983

•

Reye's syndrome: January 1975 through October 1980, 194 citations Author: Kenton, Charlotte.; Year: 1980; [Bethesda, Md.]: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1980]

•

Reye's syndrome: proceedings of an extended panel discussion held in London on November 10 and 11, 1986 Author: Wood, Clive.; Year: 1988; [Oxford?]: Royal Society of Medicine Services, c1988

•

Reye's syndrome IV: proceedings of the Fourth International Conference on Reye's Syndrome, June 21-22, 1984, Columbus, Ohio Author: Pollack, J. Dennis.; Year: 1985; Bryan, Ohio: National

Chapters on Reye’s Syndrome In order to find chapters that specifically relate to Reye’s syndrome, an excellent source of abstracts is the Combined Health Information Database. You will need to limit your search to book chapters and Reye’s syndrome using the “Detailed Search” option. Go to the 8

In addition to LOCATORPlus, in collaboration with authors and publishers, the National Center for Biotechnology Information (NCBI) is currently adapting biomedical books for the Web. The books may be accessed in two ways: (1) by searching directly using any search term or phrase (in the same way as the bibliographic database PubMed), or (2) by following the links to PubMed abstracts. Each PubMed abstract has a "Books" button that displays a facsimile of the abstract in which some phrases are hypertext links. These phrases are also found in the books available at NCBI. Click on hyperlinked results in the list of books in which the phrase is found. Currently, the majority of the links are between the books and PubMed. In the future, more links will be created between the books and other types of information, such as gene and protein sequences and macromolecular structures. See http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books.

Books 105

following hyperlink: http://chid.nih.gov/detail/detail.html. To find book chapters, use the drop boxes at the bottom of the search page where “You may refine your search by.” Select the dates and language you prefer, and the format option “Book Chapter.” Type “Reye’s syndrome” (or synonyms) into the “For these words:” box.

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CHAPTER 5. MULTIMEDIA ON REYE’S SYNDROME Overview In this chapter, we show you how to keep current on multimedia sources of information on Reye’s syndrome. We start with sources that have been summarized by federal agencies, and then show you how to find bibliographic information catalogued by the National Library of Medicine.

Bibliography: Multimedia on Reye’s Syndrome The National Library of Medicine is a rich source of information on healthcare-related multimedia productions including slides, computer software, and databases. To access the multimedia database, go to the following Web site: http://locatorplus.gov/. Select “Search LOCATORplus.” Once in the search area, simply type in Reye’s syndrome (or synonyms). Then, in the option box provided below the search box, select “Audiovisuals and Computer Files.” From there, you can choose to sort results by publication date, author, or relevance. The following multimedia has been indexed on Reye’s syndrome: •

New concepts of Reye's syndrome [videorecording] Source: Department of Pediatrics, Emory Univ., School of Medicine; Year: 1980; Format: Videorecording; Atlanta: Emory Medical Television Network: [for loan or sale by A. W. Calhoun Medical Library], 1980

•

Reye's syndrome [slide] Source: University of Michigan Medical Center, Dept. of Postgraduate Medicine and Health Professions Education; [produced by] Biomedical Media Production Unit, University of Michigan Medical Center; Year: 1978; Format: Slide; Ann Arbor: The University: [for loan and sale by its Medical Center Media Library], c1978

•

Reye's syndrome [videorecording] Source: Dept. of Pediatrics, Emory University, School of Medicine; Year: 1979; Format: Videorecording; Atlanta: Emory Medical Television Network: [for loan or sale by A. W. Calhoun Medical Library], 1979

•

Reye's syndrome [videorecording]: child killer in disguise Source: a Jaynne Fitzgerald production; Year: 1985; Format: Videorecording; Bryan, Ohio: National

•

Reye's syndrome update 1981 [videorecording] Source: presented by Department of Pediatrics, Emory University, School of Medicine; Year: 1981; Format: Videorecording; Atlanta, Ga.: Emory Medical Television Network, 1981

108 Reye’s Syndrome

109

APPENDICES

111

APPENDIX A. PHYSICIAN RESOURCES Overview In this chapter, we focus on databases and Internet-based guidelines and information resources created or written for a professional audience.

NIH Guidelines Commonly referred to as “clinical” or “professional” guidelines, the National Institutes of Health publish physician guidelines for the most common diseases. Publications are available at the following by relevant Institute9: •

Office of the Director (OD); guidelines consolidated across agencies available at http://www.nih.gov/health/consumer/conkey.htm

•

National Institute of General Medical Sciences (NIGMS); fact sheets available at http://www.nigms.nih.gov/news/facts/

•

National Library of Medicine (NLM); extensive encyclopedia (A.D.A.M., Inc.) with guidelines: http://www.nlm.nih.gov/medlineplus/healthtopics.html

•

National Cancer Institute (NCI); guidelines available at http://www.cancer.gov/cancerinfo/list.aspx?viewid=5f35036e-5497-4d86-8c2c714a9f7c8d25

•

National Eye Institute (NEI); guidelines available at http://www.nei.nih.gov/order/index.htm

•

National Heart, Lung, and Blood Institute (NHLBI); guidelines available at http://www.nhlbi.nih.gov/guidelines/index.htm

•

National Human Genome Research Institute (NHGRI); research available at http://www.genome.gov/page.cfm?pageID=10000375

•

National Institute on Aging (NIA); guidelines available at http://www.nia.nih.gov/health/

9

These publications are typically written by one or more of the various NIH Institutes.

112 Reye’s Syndrome

•

National Institute on Alcohol Abuse and Alcoholism (NIAAA); guidelines available at http://www.niaaa.nih.gov/publications/publications.htm

•

National Institute of Allergy and Infectious Diseases (NIAID); guidelines available at http://www.niaid.nih.gov/publications/

•

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); fact sheets and guidelines available at http://www.niams.nih.gov/hi/index.htm

•

National Institute of Child Health and Human Development (NICHD); guidelines available at http://www.nichd.nih.gov/publications/pubskey.cfm

•

National Institute on Deafness and Other Communication Disorders (NIDCD); fact sheets and guidelines at http://www.nidcd.nih.gov/health/

•

National Institute of Dental and Craniofacial Research (NIDCR); guidelines available at http://www.nidr.nih.gov/health/

•

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); guidelines available at http://www.niddk.nih.gov/health/health.htm

•

National Institute on Drug Abuse (NIDA); guidelines available at http://www.nida.nih.gov/DrugAbuse.html

•

National Institute of Environmental Health Sciences (NIEHS); environmental health information available at http://www.niehs.nih.gov/external/facts.htm

•

National Institute of Mental Health (NIMH); guidelines available at http://www.nimh.nih.gov/practitioners/index.cfm

•

National Institute of Neurological Disorders and Stroke (NINDS); neurological disorder information pages available at http://www.ninds.nih.gov/health_and_medical/disorder_index.htm

•

National Institute of Nursing Research (NINR); publications on selected illnesses at http://www.nih.gov/ninr/news-info/publications.html

•

National Institute of Biomedical Imaging and Bioengineering; general information at http://grants.nih.gov/grants/becon/becon_info.htm

•

Center for Information Technology (CIT); referrals to other agencies based on keyword searches available at http://kb.nih.gov/www_query_main.asp

•

National Center for Complementary and Alternative Medicine (NCCAM); health information available at http://nccam.nih.gov/health/

•

National Center for Research Resources (NCRR); various information directories available at http://www.ncrr.nih.gov/publications.asp

•

Office of Rare Diseases; various fact sheets available at http://rarediseases.info.nih.gov/html/resources/rep_pubs.html

•

Centers for Disease Control and Prevention; various fact sheets on infectious diseases available at http://www.cdc.gov/publications.htm

Physician Resources 113

NIH Databases In addition to the various Institutes of Health that publish professional guidelines, the NIH has designed a number of databases for professionals.10 Physician-oriented resources provide a wide variety of information related to the biomedical and health sciences, both past and present. The format of these resources varies. Searchable databases, bibliographic citations, full-text articles (when available), archival collections, and images are all available. The following are referenced by the National Library of Medicine:11 •

Bioethics: Access to published literature on the ethical, legal, and public policy issues surrounding healthcare and biomedical research. This information is provided in conjunction with the Kennedy Institute of Ethics located at Georgetown University, Washington, D.C.: http://www.nlm.nih.gov/databases/databases_bioethics.html

•

HIV/AIDS Resources: Describes various links and databases dedicated to HIV/AIDS research: http://www.nlm.nih.gov/pubs/factsheets/aidsinfs.html

•

NLM Online Exhibitions: Describes “Exhibitions in the History of Medicine”: http://www.nlm.nih.gov/exhibition/exhibition.html. Additional resources for historical scholarship in medicine: http://www.nlm.nih.gov/hmd/hmd.html

•

Biotechnology Information: Access to public databases. The National Center for Biotechnology Information conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information for the better understanding of molecular processes affecting human health and disease: http://www.ncbi.nlm.nih.gov/

•

Population Information: The National Library of Medicine provides access to worldwide coverage of population, family planning, and related health issues, including family planning technology and programs, fertility, and population law and policy: http://www.nlm.nih.gov/databases/databases_population.html

•

Cancer Information: Access to cancer-oriented databases: http://www.nlm.nih.gov/databases/databases_cancer.html

•

Profiles in Science: Offering the archival collections of prominent twentieth-century biomedical scientists to the public through modern digital technology: http://www.profiles.nlm.nih.gov/

•

Chemical Information: Provides links to various chemical databases and references: http://sis.nlm.nih.gov/Chem/ChemMain.html

•

Clinical Alerts: Reports the release of findings from the NIH-funded clinical trials where such release could significantly affect morbidity and mortality: http://www.nlm.nih.gov/databases/alerts/clinical_alerts.html

•

Space Life Sciences: Provides links and information to space-based research (including NASA): http://www.nlm.nih.gov/databases/databases_space.html

•

MEDLINE: Bibliographic database covering the fields of medicine, nursing, dentistry, veterinary medicine, the healthcare system, and the pre-clinical sciences: http://www.nlm.nih.gov/databases/databases_medline.html

10

Remember, for the general public, the National Library of Medicine recommends the databases referenced in MEDLINEplus (http://medlineplus.gov/ or http://www.nlm.nih.gov/medlineplus/databases.html). 11 See http://www.nlm.nih.gov/databases/databases.html.

114 Reye’s Syndrome

•

Toxicology and Environmental Health Information (TOXNET): Databases covering toxicology and environmental health: http://sis.nlm.nih.gov/Tox/ToxMain.html

•

Visible Human Interface: Anatomically detailed, three-dimensional representations of normal male and female human bodies: http://www.nlm.nih.gov/research/visible/visible_human.html

The NLM Gateway12 The NLM (National Library of Medicine) Gateway is a Web-based system that lets users search simultaneously in multiple retrieval systems at the U.S. National Library of Medicine (NLM). It allows users of NLM services to initiate searches from one Web interface, providing one-stop searching for many of NLM’s information resources or databases.13 To use the NLM Gateway, simply go to the search site at http://gateway.nlm.nih.gov/gw/Cmd. Type “Reye’s syndrome” (or synonyms) into the search box and click “Search.” The results will be presented in a tabular form, indicating the number of references in each database category. Results Summary Category Journal Articles Books / Periodicals / Audio Visual Consumer Health Meeting Abstracts Other Collections Total

Items Found 1755 23 5 1 0 1784

HSTAT14 HSTAT is a free, Web-based resource that provides access to full-text documents used in healthcare decision-making.15 These documents include clinical practice guidelines, quickreference guides for clinicians, consumer health brochures, evidence reports and technology assessments from the Agency for Healthcare Research and Quality (AHRQ), as well as AHRQ’s Put Prevention Into Practice.16 Simply search by “Reye’s syndrome” (or synonyms) at the following Web site: http://text.nlm.nih.gov.

12

Adapted from NLM: http://gateway.nlm.nih.gov/gw/Cmd?Overview.x.

13

The NLM Gateway is currently being developed by the Lister Hill National Center for Biomedical Communications (LHNCBC) at the National Library of Medicine (NLM) of the National Institutes of Health (NIH). 14 Adapted from HSTAT: http://www.nlm.nih.gov/pubs/factsheets/hstat.html. 15 16

The HSTAT URL is http://hstat.nlm.nih.gov/.

Other important documents in HSTAT include: the National Institutes of Health (NIH) Consensus Conference Reports and Technology Assessment Reports; the HIV/AIDS Treatment Information Service (ATIS) resource documents; the Substance Abuse and Mental Health Services Administration's Center for Substance Abuse Treatment (SAMHSA/CSAT) Treatment Improvement Protocols (TIP) and Center for Substance Abuse Prevention (SAMHSA/CSAP) Prevention Enhancement Protocols System (PEPS); the Public Health Service (PHS) Preventive Services Task Force's Guide to Clinical Preventive Services; the independent, nonfederal Task Force on Community Services’ Guide to Community Preventive Services; and the Health Technology Advisory Committee (HTAC) of the Minnesota Health Care Commission (MHCC) health technology evaluations.

Physician Resources 115

Coffee Break: Tutorials for Biologists17 Coffee Break is a general healthcare site that takes a scientific view of the news and covers recent breakthroughs in biology that may one day assist physicians in developing treatments. Here you will find a collection of short reports on recent biological discoveries. Each report incorporates interactive tutorials that demonstrate how bioinformatics tools are used as a part of the research process. Currently, all Coffee Breaks are written by NCBI staff.18 Each report is about 400 words and is usually based on a discovery reported in one or more articles from recently published, peer-reviewed literature.19 This site has new articles every few weeks, so it can be considered an online magazine of sorts. It is intended for general background information. You can access the Coffee Break Web site at the following hyperlink: http://www.ncbi.nlm.nih.gov/Coffeebreak/.

Other Commercial Databases In addition to resources maintained by official agencies, other databases exist that are commercial ventures addressing medical professionals. Here are some examples that may interest you: •

CliniWeb International: Index and table of contents to selected clinical information on the Internet; see http://www.ohsu.edu/cliniweb/.

•

Medical World Search: Searches full text from thousands of selected medical sites on the Internet; see http://www.mwsearch.com/.

17 Adapted 18

from http://www.ncbi.nlm.nih.gov/Coffeebreak/Archive/FAQ.html.

The figure that accompanies each article is frequently supplied by an expert external to NCBI, in which case the source of the figure is cited. The result is an interactive tutorial that tells a biological story. 19 After a brief introduction that sets the work described into a broader context, the report focuses on how a molecular understanding can provide explanations of observed biology and lead to therapies for diseases. Each vignette is accompanied by a figure and hypertext links that lead to a series of pages that interactively show how NCBI tools and resources are used in the research process.

117

APPENDIX B. PATIENT RESOURCES Overview Official agencies, as well as federally funded institutions supported by national grants, frequently publish a variety of guidelines written with the patient in mind. These are typically called “Fact Sheets” or “Guidelines.” They can take the form of a brochure, information kit, pamphlet, or flyer. Often they are only a few pages in length. Since new guidelines on Reye’s syndrome can appear at any moment and be published by a number of sources, the best approach to finding guidelines is to systematically scan the Internet-based services that post them.

Patient Guideline Sources The remainder of this chapter directs you to sources which either publish or can help you find additional guidelines on topics related to Reye’s syndrome. Due to space limitations, these sources are listed in a concise manner. Do not hesitate to consult the following sources by either using the Internet hyperlink provided, or, in cases where the contact information is provided, contacting the publisher or author directly. The National Institutes of Health The NIH gateway to patients is located at http://health.nih.gov/. From this site, you can search across various sources and institutes, a number of which are summarized below. Topic Pages: MEDLINEplus The National Library of Medicine has created a vast and patient-oriented healthcare information portal called MEDLINEplus. Within this Internet-based system are “health topic pages” which list links to available materials relevant to Reye’s syndrome. To access this system, log on to http://www.nlm.nih.gov/medlineplus/healthtopics.html. From there you can either search using the alphabetical index or browse by broad topic areas. Recently, MEDLINEplus listed the following when searched for “Reye’s syndrome”:

118 Reye’s Syndrome

•

Other Guides Adrenal Gland Disorders http://www.nlm.nih.gov/medlineplus/adrenalglanddisorders.html Chickenpox http://www.nlm.nih.gov/medlineplus/chickenpox.html Cirrhosis http://www.nlm.nih.gov/medlineplus/cirrhosis.html Down Syndrome http://www.nlm.nih.gov/medlineplus/downsyndrome.html Hepatitis http://www.nlm.nih.gov/medlineplus/hepatitis.html Hepatitis A http://www.nlm.nih.gov/medlineplus/hepatitisa.html Hepatitis C http://www.nlm.nih.gov/medlineplus/hepatitisc.html Laboratory Tests http://www.nlm.nih.gov/medlineplus/laboratorytests.html Liver Diseases http://www.nlm.nih.gov/medlineplus/liverdiseasesgeneral.html Liver Transplantation http://www.nlm.nih.gov/medlineplus/livertransplantation.html Sjogren's Syndrome http://www.nlm.nih.gov/medlineplus/sjogrenssyndrome.html Tourette Syndrome http://www.nlm.nih.gov/medlineplus/tourettesyndrome.html Turner's Syndrome http://www.nlm.nih.gov/medlineplus/turnerssyndrome.html

Within the health topic page dedicated to Reye’s syndrome, the following was listed: •

General/Overviews Reye's Syndrome Source: Nemours Foundation http://kidshealth.org/parent/infections/bacterial_viral/reye.html What is Reye's Syndrome? Source: National Reye's Syndrome Foundation http://www.reyessyndrome.org/what.htm

•

Treatment Treatment of Reye's Syndrome Source: National Reye's Syndrome Foundation http://www.reyessyndrome.org/treat.htm

Patient Resources 119

•

Children Reye Syndrome Source: American Academy of Pediatrics http://www.medem.com/medlb/article_detaillb.cfm?article_ID=ZZZKM6MUEDC &sub_cat=24

•

From the National Institutes of Health Reye's Syndrome http://www.ninds.nih.gov/health_and_medical/disorders/reyes_syndrome.htm

•

Organizations National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ National Reye's Syndrome Foundation http://www.reyessyndrome.org/

•

Prevention/Screening Aspirin or Salicylate-Containing Medications Source: National Reye's Syndrome Foundation http://www.reyessyndrome.org/aspirin2.htm What is the Role of Aspirin? Source: National Reye's Syndrome Foundation http://www.reyessyndrome.org/aspirin.htm

•

Statistics CDC Study Shows Sharp Decline in Reye's Syndrome Among U.S. Children Source: Centers for Disease Control and Prevention http://www.cdc.gov/ncidod/diseases/reye.htm

You may also choose to use the search utility provided by MEDLINEplus at the following Web address: http://www.nlm.nih.gov/medlineplus/. Simply type a keyword into the search box and click “Search.” This utility is similar to the NIH search utility, with the exception that it only includes materials that are linked within the MEDLINEplus system (mostly patient-oriented information). It also has the disadvantage of generating unstructured results. We recommend, therefore, that you use this method only if you have a very targeted search. The NIH Search Utility The NIH search utility allows you to search for documents on over 100 selected Web sites that comprise the NIH-WEB-SPACE. Each of these servers is “crawled” and indexed on an ongoing basis. Your search will produce a list of various documents, all of which will relate in some way to Reye’s syndrome. The drawbacks of this approach are that the information is not organized by theme and that the references are often a mix of information for professionals and patients. Nevertheless, a large number of the listed Web sites provide useful background information. We can only recommend this route, therefore, for relatively

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rare or specific disorders, or when using highly targeted searches. To use the NIH search utility, visit the following Web page: http://search.nih.gov/index.html. Additional Web Sources

A number of Web sites are available to the public that often link to government sites. These can also point you in the direction of essential information. The following is a representative sample: •

AOL: http://search.aol.com/cat.adp?id=168&layer=&from=subcats

•

Family Village: http://www.familyvillage.wisc.edu/specific.htm

•

Google: http://directory.google.com/Top/Health/Conditions_and_Diseases/

•

Med Help International: http://www.medhelp.org/HealthTopics/A.html

•

Open Directory Project: http://dmoz.org/Health/Conditions_and_Diseases/

•

Yahoo.com: http://dir.yahoo.com/Health/Diseases_and_Conditions/

•

WebMDHealth: http://my.webmd.com/health_topics

Associations and Reye’s Syndrome The following is a list of associations that provide information on and resources relating to Reye’s syndrome: •

American Liver Foundation Address: Telephone: (212) 668-1000 Toll-free: (800) 465-4837 Fax: (212) 483-8179 Email: [email protected] Web Site: http://www.liverfoundation.org Background: The American Liver Foundation (ALF) is a national voluntary non-profit organization dedicated to the prevention, treatment, and cure of hepatitis and other liver diseases through research, education and advocacy. Established in 1976, ALF provides a national HelpLine, educational information and programs, physician referrals, extensive scientific research grants, and a nationwide network of chapters and support groups. Relevant area(s) of interest: Reye Syndrome

•

Canadian Liver Foundation Address: Telephone: (416) 491-3353 Toll-free: (800) 563-5483 Fax: (416) 491-4952 Email: [email protected] Web Site: http://www.liver.ca

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Background: The Canadian Liver Foundation (CLF) is a not-for-profit health organization committed to reducing the incidence and impact of liver disease by providing support for research and education into the causes, diagnosis, prevention and treatment of more than 100 diseases of the liver. Established in 1969, the CLF has established 30 chapters across Canada and provides information in both English and French. Some of the liver diseases discussed in brochures and medical information sheets available from CLF include gallstones, hemochromatosis, primary biliary cirrhosis, several forms of hepatitis, porphyria, fatty liver, and liver cancer. Further information is provided on liver transplantation, the effects of sodium, and management of variceal bleeding. The Foundation also produces a newsletter and maintains a web site. Relevant area(s) of interest: Reye Syndrome •

Children's Gaucher Research Fund Address: Telephone: (916) 797-3700 Toll-free: Fax: (916) 797-3707 Email: [email protected] Web Site: http://www.childrensgaucher.org Background: The Children s Gaucher Research Fund is a non-profit organization that raises money for medical research aimed at finding a cure for Gaucher disease Type 2 and Type 3. It also provides support to families of affected children and allows families who have lost a child to this disease to participate, in their child s honor, in fund-raising for medical research. Gaucher disease is a rare, inherited, metabolic disorder in which the body is unable to rid itself of worn-out red and white blood cells so that these cells accumulate in the liver, spleen, bone marrow, and, sometimes, heart and lungs. In Children s Gaucher disease, more commonly known as Types 2 and 3 Gaucher disease, all of the above-mentioned symptoms exist, but the disease is also characterized by certain neurologic symptoms such as ocular motor apraxia, a defect of horizontal eye movements; breathing problems and, sometimes, speech or cognitive delay. Founded in 1999, the Children s Gaucher Research Fund has approximately 1900 members. It serves families in the United States and Canada.

•

March of Dimes Birth Defects Foundation Address: Telephone: (914) 428-7100 Toll-free: (888) 663-4637 Fax: (914) 997-4763 Email: [email protected] Web Site: http://www.marchofdimes.com Background: The March of Dimes Birth Defects Foundation is a national not-for-profit organization that was established in 1938. The mission of the Foundation is to improve the health of babies by preventing birth defects and infant mortality. The March of Dimes funds programs of research, community services, education, and advocacy. Educational programs that seek to prevent birth defects are important to the Foundation and to that end it also produces a wide variety of printed informational materials and videos. The Pregnancy and Newborn Health Education Center staffs trained health

122 Reye’s Syndrome

information specialists who provide researched information on pregnancy issues, complications and risks, newborn care, birth defects, genetic diseases and related topics as well as referrals to relevant organizations and support groups. •

National Reye's Syndrome Foundation, Inc Address: Telephone: (419) 636-2679 Toll-free: (800) 233-7393 Fax: (419) 636-9897 Email: [email protected] Web Site: http://www.reyessyndrome.org Background: The National Reye s Syndrome Foundation, Inc., is a voluntary not-forprofit service organization dedicated to providing funding for basic research, awareness programs for the general public and the medical community, and emotional support and guidance for individuals with Reye s syndrome and their families. Reye s syndrome is a rare disease that usually follows a viral infection, such as influenza or chicken pox, and is strongly associated with the use of salicylates (e.g., aspirin). Reye's syndrome affects the liver and brain. Established in 1974, the National Reye s Syndrome Foundation promotes patient and family advocacy; provides appropriate referrals (e.g., to support groups); and offers a variety of educational and supportive information through its database, bulletins, fact sheets, brochures, audio-visual aids, and regular newsletter. Languages supported by the Foundation include English, Spanish, Laotian, Cambodian, and Vietnamese. Relevant area(s) of interest: Reye Syndrome

Finding Associations There are several Internet directories that provide lists of medical associations with information on or resources relating to Reye’s syndrome. By consulting all of associations listed in this chapter, you will have nearly exhausted all sources for patient associations concerned with Reye’s syndrome. The National Health Information Center (NHIC) The National Health Information Center (NHIC) offers a free referral service to help people find organizations that provide information about Reye’s syndrome. For more information, see the NHIC’s Web site at http://www.health.gov/NHIC/ or contact an information specialist by calling 1-800-336-4797. Directory of Health Organizations The Directory of Health Organizations, provided by the National Library of Medicine Specialized Information Services, is a comprehensive source of information on associations. The Directory of Health Organizations database can be accessed via the Internet at http://www.sis.nlm.nih.gov/Dir/DirMain.html. It is composed of two parts: DIRLINE and Health Hotlines.

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The DIRLINE database comprises some 10,000 records of organizations, research centers, and government institutes and associations that primarily focus on health and biomedicine. To access DIRLINE directly, go to the following Web site: http://dirline.nlm.nih.gov/. Simply type in “Reye’s syndrome” (or a synonym), and you will receive information on all relevant organizations listed in the database. Health Hotlines directs you to toll-free numbers to over 300 organizations. You can access this database directly at http://www.sis.nlm.nih.gov/hotlines/. On this page, you are given the option to search by keyword or by browsing the subject list. When you have received your search results, click on the name of the organization for its description and contact information. The Combined Health Information Database Another comprehensive source of information on healthcare associations is the Combined Health Information Database. Using the “Detailed Search” option, you will need to limit your search to “Organizations” and “Reye’s syndrome”. Type the following hyperlink into your Web browser: http://chid.nih.gov/detail/detail.html. To find associations, use the drop boxes at the bottom of the search page where “You may refine your search by.” For publication date, select “All Years.” Then, select your preferred language and the format option “Organization Resource Sheet.” Type “Reye’s syndrome” (or synonyms) into the “For these words:” box. You should check back periodically with this database since it is updated every three months. The National Organization for Rare Disorders, Inc. The National Organization for Rare Disorders, Inc. has prepared a Web site that provides, at no charge, lists of associations organized by health topic. You can access this database at the following Web site: http://www.rarediseases.org/search/orgsearch.html. Type “Reye’s syndrome” (or a synonym) into the search box, and click “Submit Query.”

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APPENDIX C. FINDING MEDICAL LIBRARIES Overview In this Appendix, we show you how to quickly find a medical library in your area.

Preparation Your local public library and medical libraries have interlibrary loan programs with the National Library of Medicine (NLM), one of the largest medical collections in the world. According to the NLM, most of the literature in the general and historical collections of the National Library of Medicine is available on interlibrary loan to any library. If you would like to access NLM medical literature, then visit a library in your area that can request the publications for you.20

Finding a Local Medical Library The quickest method to locate medical libraries is to use the Internet-based directory published by the National Network of Libraries of Medicine (NN/LM). This network includes 4626 members and affiliates that provide many services to librarians, health professionals, and the public. To find a library in your area, simply visit http://nnlm.gov/members/adv.html or call 1-800-338-7657.

Medical Libraries in the U.S. and Canada In addition to the NN/LM, the National Library of Medicine (NLM) lists a number of libraries with reference facilities that are open to the public. The following is the NLM’s list and includes hyperlinks to each library’s Web site. These Web pages can provide information on hours of operation and other restrictions. The list below is a small sample of

20

Adapted from the NLM: http://www.nlm.nih.gov/psd/cas/interlibrary.html.

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libraries recommended by the National Library of Medicine (sorted alphabetically by name of the U.S. state or Canadian province where the library is located)21: •

Alabama: Health InfoNet of Jefferson County (Jefferson County Library Cooperative, Lister Hill Library of the Health Sciences), http://www.uab.edu/infonet/

•

Alabama: Richard M. Scrushy Library (American Sports Medicine Institute)

•

Arizona: Samaritan Regional Medical Center: The Learning Center (Samaritan Health System, Phoenix, Arizona), http://www.samaritan.edu/library/bannerlibs.htm

•

California: Kris Kelly Health Information Center (St. Joseph Health System, Humboldt), http://www.humboldt1.com/~kkhic/index.html

•

California: Community Health Library of Los Gatos, http://www.healthlib.org/orgresources.html

•

California: Consumer Health Program and Services (CHIPS) (County of Los Angeles Public Library, Los Angeles County Harbor-UCLA Medical Center Library) - Carson, CA, http://www.colapublib.org/services/chips.html

•

California: Gateway Health Library (Sutter Gould Medical Foundation)

•

California: Health Library (Stanford University Medical Center), http://wwwmed.stanford.edu/healthlibrary/

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California: Patient Education Resource Center - Health Information and Resources (University of California, San Francisco), http://sfghdean.ucsf.edu/barnett/PERC/default.asp

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California: Redwood Health Library (Petaluma Health Care District), http://www.phcd.org/rdwdlib.html

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California: Los Gatos PlaneTree Health Library, http://planetreesanjose.org/

•

California: Sutter Resource Library (Sutter Hospitals Foundation, Sacramento), http://suttermedicalcenter.org/library/

•

California: Health Sciences Libraries (University of California, Davis), http://www.lib.ucdavis.edu/healthsci/

•

California: ValleyCare Health Library & Ryan Comer Cancer Resource Center (ValleyCare Health System, Pleasanton), http://gaelnet.stmarysca.edu/other.libs/gbal/east/vchl.html

•

California: Washington Community Health Resource Library (Fremont), http://www.healthlibrary.org/

•

Colorado: William V. Gervasini Memorial Library (Exempla Healthcare), http://www.saintjosephdenver.org/yourhealth/libraries/

•

Connecticut: Hartford Hospital Health Science Libraries (Hartford Hospital), http://www.harthosp.org/library/

•

Connecticut: Healthnet: Connecticut Consumer Health Information Center (University of Connecticut Health Center, Lyman Maynard Stowe Library), http://library.uchc.edu/departm/hnet/

21

Abstracted from http://www.nlm.nih.gov/medlineplus/libraries.html.

Finding Medical Libraries 127

•

Connecticut: Waterbury Hospital Health Center Library (Waterbury Hospital, Waterbury), http://www.waterburyhospital.com/library/consumer.shtml

•

Delaware: Consumer Health Library (Christiana Care Health System, Eugene du Pont Preventive Medicine & Rehabilitation Institute, Wilmington), http://www.christianacare.org/health_guide/health_guide_pmri_health_info.cfm

•

Delaware: Lewis B. Flinn Library (Delaware Academy of Medicine, Wilmington), http://www.delamed.org/chls.html

•

Georgia: Family Resource Library (Medical College of Georgia, Augusta), http://cmc.mcg.edu/kids_families/fam_resources/fam_res_lib/frl.htm

•

Georgia: Health Resource Center (Medical Center of Central Georgia, Macon), http://www.mccg.org/hrc/hrchome.asp

•

Hawaii: Hawaii Medical Library: Consumer Health Information Service (Hawaii Medical Library, Honolulu), http://hml.org/CHIS/

•

Idaho: DeArmond Consumer Health Library (Kootenai Medical Center, Coeur d’Alene), http://www.nicon.org/DeArmond/index.htm

•

Illinois: Health Learning Center of Northwestern Memorial Hospital (Chicago), http://www.nmh.org/health_info/hlc.html

•

Illinois: Medical Library (OSF Saint Francis Medical Center, Peoria), http://www.osfsaintfrancis.org/general/library/

•

Kentucky: Medical Library - Services for Patients, Families, Students & the Public (Central Baptist Hospital, Lexington), http://www.centralbap.com/education/community/library.cfm

•

Kentucky: University of Kentucky - Health Information Library (Chandler Medical Center, Lexington), http://www.mc.uky.edu/PatientEd/

•

Louisiana: Alton Ochsner Medical Foundation Library (Alton Ochsner Medical Foundation, New Orleans), http://www.ochsner.org/library/

•

Louisiana: Louisiana State University Health Sciences Center Medical LibraryShreveport, http://lib-sh.lsuhsc.edu/

•

Maine: Franklin Memorial Hospital Medical Library (Franklin Memorial Hospital, Farmington), http://www.fchn.org/fmh/lib.htm

•

Maine: Gerrish-True Health Sciences Library (Central Maine Medical Center, Lewiston), http://www.cmmc.org/library/library.html

•

Maine: Hadley Parrot Health Science Library (Eastern Maine Healthcare, Bangor), http://www.emh.org/hll/hpl/guide.htm

•

Maine: Maine Medical Center Library (Maine Medical Center, Portland), http://www.mmc.org/library/

•

Maine: Parkview Hospital (Brunswick), http://www.parkviewhospital.org/

•

Maine: Southern Maine Medical Center Health Sciences Library (Southern Maine Medical Center, Biddeford), http://www.smmc.org/services/service.php3?choice=10

•

Maine: Stephens Memorial Hospital’s Health Information Library (Western Maine Health, Norway), http://www.wmhcc.org/Library/

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•

Manitoba, Canada: Consumer & Patient Health Information Service (University of Manitoba Libraries), http://www.umanitoba.ca/libraries/units/health/reference/chis.html

•

Manitoba, Canada: J.W. Crane Memorial Library (Deer Lodge Centre, Winnipeg), http://www.deerlodge.mb.ca/crane_library/about.asp

•

Maryland: Health Information Center at the Wheaton Regional Library (Montgomery County, Dept. of Public Libraries, Wheaton Regional Library), http://www.mont.lib.md.us/healthinfo/hic.asp

•

Massachusetts: Baystate Medical Center Library (Baystate Health System), http://www.baystatehealth.com/1024/

•

Massachusetts: Boston University Medical Center Alumni Medical Library (Boston University Medical Center), http://med-libwww.bu.edu/library/lib.html

•

Massachusetts: Lowell General Hospital Health Sciences Library (Lowell General Hospital, Lowell), http://www.lowellgeneral.org/library/HomePageLinks/WWW.htm

•

Massachusetts: Paul E. Woodard Health Sciences Library (New England Baptist Hospital, Boston), http://www.nebh.org/health_lib.asp

•

Massachusetts: St. Luke’s Hospital Health Sciences Library (St. Luke’s Hospital, Southcoast Health System, New Bedford), http://www.southcoast.org/library/

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Massachusetts: Treadwell Library Consumer Health Reference Center (Massachusetts General Hospital), http://www.mgh.harvard.edu/library/chrcindex.html

•

Massachusetts: UMass HealthNet (University of Massachusetts Medical School, Worchester), http://healthnet.umassmed.edu/

•

Michigan: Botsford General Hospital Library - Consumer Health (Botsford General Hospital, Library & Internet Services), http://www.botsfordlibrary.org/consumer.htm

•

Michigan: Helen DeRoy Medical Library (Providence Hospital and Medical Centers), http://www.providence-hospital.org/library/

•

Michigan: Marquette General Hospital - Consumer Health Library (Marquette General Hospital, Health Information Center), http://www.mgh.org/center.html

•

Michigan: Patient Education Resouce Center - University of Michigan Cancer Center (University of Michigan Comprehensive Cancer Center, Ann Arbor), http://www.cancer.med.umich.edu/learn/leares.htm

•

Michigan: Sladen Library & Center for Health Information Resources - Consumer Health Information (Detroit), http://www.henryford.com/body.cfm?id=39330

•

Montana: Center for Health Information (St. Patrick Hospital and Health Sciences Center, Missoula)

•

National: Consumer Health Library Directory (Medical Library Association, Consumer and Patient Health Information Section), http://caphis.mlanet.org/directory/index.html

•

National: National Network of Libraries of Medicine (National Library of Medicine) provides library services for health professionals in the United States who do not have access to a medical library, http://nnlm.gov/

•

National: NN/LM List of Libraries Serving the Public (National Network of Libraries of Medicine), http://nnlm.gov/members/

Finding Medical Libraries 129

•

Nevada: Health Science Library, West Charleston Library (Las Vegas-Clark County Library District, Las Vegas), http://www.lvccld.org/special_collections/medical/index.htm

•

New Hampshire: Dartmouth Biomedical Libraries (Dartmouth College Library, Hanover), http://www.dartmouth.edu/~biomed/resources.htmld/conshealth.htmld/

•

New Jersey: Consumer Health Library (Rahway Hospital, Rahway), http://www.rahwayhospital.com/library.htm

•

New Jersey: Dr. Walter Phillips Health Sciences Library (Englewood Hospital and Medical Center, Englewood), http://www.englewoodhospital.com/links/index.htm

•

New Jersey: Meland Foundation (Englewood Hospital and Medical Center, Englewood), http://www.geocities.com/ResearchTriangle/9360/

•

New York: Choices in Health Information (New York Public Library) - NLM Consumer Pilot Project participant, http://www.nypl.org/branch/health/links.html

•

New York: Health Information Center (Upstate Medical University, State University of New York, Syracuse), http://www.upstate.edu/library/hic/

•

New York: Health Sciences Library (Long Island Jewish Medical Center, New Hyde Park), http://www.lij.edu/library/library.html

•

New York: ViaHealth Medical Library (Rochester General Hospital), http://www.nyam.org/library/

•

Ohio: Consumer Health Library (Akron General Medical Center, Medical & Consumer Health Library), http://www.akrongeneral.org/hwlibrary.htm

•

Oklahoma: The Health Information Center at Saint Francis Hospital (Saint Francis Health System, Tulsa), http://www.sfh-tulsa.com/services/healthinfo.asp

•

Oregon: Planetree Health Resource Center (Mid-Columbia Medical Center, The Dalles), http://www.mcmc.net/phrc/

•

Pennsylvania: Community Health Information Library (Milton S. Hershey Medical Center, Hershey), http://www.hmc.psu.edu/commhealth/

•

Pennsylvania: Community Health Resource Library (Geisinger Medical Center, Danville), http://www.geisinger.edu/education/commlib.shtml

•

Pennsylvania: HealthInfo Library (Moses Taylor Hospital, Scranton), http://www.mth.org/healthwellness.html

•

Pennsylvania: Hopwood Library (University of Pittsburgh, Health Sciences Library System, Pittsburgh), http://www.hsls.pitt.edu/guides/chi/hopwood/index_html

•

Pennsylvania: Koop Community Health Information Center (College of Physicians of Philadelphia), http://www.collphyphil.org/kooppg1.shtml

•

Pennsylvania: Learning Resources Center - Medical Library (Susquehanna Health System, Williamsport), http://www.shscares.org/services/lrc/index.asp

•

Pennsylvania: Medical Library (UPMC Health System, Pittsburgh), http://www.upmc.edu/passavant/library.htm

•

Quebec, Canada: Medical Library (Montreal General Hospital), http://www.mghlib.mcgill.ca/

130 Reye’s Syndrome

•

South Dakota: Rapid City Regional Hospital Medical Library (Rapid City Regional Hospital), http://www.rcrh.org/Services/Library/Default.asp

•

Texas: Houston HealthWays (Houston Academy of Medicine-Texas Medical Center Library), http://hhw.library.tmc.edu/

•

Washington: Community Health Library (Kittitas Valley Community Hospital), http://www.kvch.com/

•

Washington: Southwest Washington Medical Center Library (Southwest Washington Medical Center, Vancouver), http://www.swmedicalcenter.com/body.cfm?id=72

131

ONLINE GLOSSARIES The Internet provides access to a number of free-to-use medical dictionaries. The National Library of Medicine has compiled the following list of online dictionaries: •

ADAM Medical Encyclopedia (A.D.A.M., Inc.), comprehensive medical reference: http://www.nlm.nih.gov/medlineplus/encyclopedia.html

•

MedicineNet.com Medical Dictionary (MedicineNet, Inc.): http://www.medterms.com/Script/Main/hp.asp

•

Merriam-Webster Medical Dictionary (Inteli-Health, Inc.): http://www.intelihealth.com/IH/

•

Multilingual Glossary of Technical and Popular Medical Terms in Eight European Languages (European Commission) - Danish, Dutch, English, French, German, Italian, Portuguese, and Spanish: http://allserv.rug.ac.be/~rvdstich/eugloss/welcome.html

•

On-line Medical Dictionary (CancerWEB): http://cancerweb.ncl.ac.uk/omd/

•

Rare Diseases Terms (Office of Rare Diseases): http://ord.aspensys.com/asp/diseases/diseases.asp

•

Technology Glossary (National Library of Medicine) - Health Care Technology: http://www.nlm.nih.gov/nichsr/ta101/ta10108.htm

Beyond these, MEDLINEplus contains a very patient-friendly encyclopedia covering every aspect of medicine (licensed from A.D.A.M., Inc.). The ADAM Medical Encyclopedia can be accessed at http://www.nlm.nih.gov/medlineplus/encyclopedia.html. ADAM is also available on commercial Web sites such as drkoop.com (http://www.drkoop.com/) and Web MD (http://my.webmd.com/adam/asset/adam_disease_articles/a_to_z/a). The NIH suggests the following Web sites in the ADAM Medical Encyclopedia when searching for information on Reye’s syndrome: •

Basic Guidelines for Reye’s Syndrome Hepatic encephalopathy Web site: http://www.nlm.nih.gov/medlineplus/ency/article/000302.htm Reye's syndrome Web site: http://www.nlm.nih.gov/medlineplus/ency/article/001565.htm Reye's syndrome - resources Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002192.htm RLS Web site: http://www.nlm.nih.gov/medlineplus/ency/article/000807.htm

•

Signs & Symptoms for Reye’s Syndrome Changes in mental status Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003205.htm

132 Reye’s Syndrome

Coma Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003202.htm Confusion Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003205.htm Decerebrate posture Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003299.htm Double vision Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003029.htm Edema Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003103.htm Hearing loss Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003044.htm Hepatomegaly Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003275.htm Irritability Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003214.htm Lethargy Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003088.htm Loss of consciousness Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003202.htm Mental changes Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003205.htm Mental status changes Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003205.htm Muscle function loss Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003190.htm Nausea Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003117.htm Paralysis Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003190.htm Respiratory arrest Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003069.htm Seizures Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003200.htm

Online Glossaries 133

Speech difficulties Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003204.htm Stress Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003211.htm Stuporous Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003202.htm Swelling Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003103.htm Vomiting Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003117.htm Weakness Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003174.htm •

Diagnostics and Tests for Reye’s Syndrome Alkaline phosphatase Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003470.htm ALT Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003473.htm AST Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003472.htm Bilirubin Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003479.htm Biopsy Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003416.htm Blood chemistry tests Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003468.htm Blood gases Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003855.htm CPK Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003503.htm Differential Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm EEG Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003931.htm

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Head CT Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003786.htm Head MRI scan Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003791.htm LDH Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm Liver biopsy Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003895.htm Liver function tests Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003436.htm Prothrombin time Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003652.htm Serum ammonia test Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003506.htm Spinal tap Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003428.htm •

Nutrition for Reye’s Syndrome Inborn errors of metabolism Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002438.htm

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Surgery and Procedures for Reye’s Syndrome Craniotomy Web site: http://www.nlm.nih.gov/medlineplus/ency/article/003018.htm

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Background Topics for Reye’s Syndrome Acute Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002215.htm Electrolytes Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002350.htm Hepatic Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002378.htm Incidence Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002387.htm Intravenous Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002383.htm

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Respiratory Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002290.htm Reye's syndrome - support group Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002192.htm Support groups Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002150.htm Toxins Web site: http://www.nlm.nih.gov/medlineplus/ency/article/002331.htm

Online Dictionary Directories The following are additional online directories compiled by the National Library of Medicine, including a number of specialized medical dictionaries: •

Medical Dictionaries: Medical & Biological (World Health Organization): http://www.who.int/hlt/virtuallibrary/English/diction.htm#Medical

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MEL-Michigan Electronic Library List of Online Health and Medical Dictionaries (Michigan Electronic Library): http://mel.lib.mi.us/health/health-dictionaries.html

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Patient Education: Glossaries (DMOZ Open Directory Project): http://dmoz.org/Health/Education/Patient_Education/Glossaries/

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Web of Online Dictionaries (Bucknell University): http://www.yourdictionary.com/diction5.html#medicine

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REYE’S SYNDROME DICTIONARY The definitions below are derived from official public sources, including the National Institutes of Health [NIH] and the European Union [EU]. Abdominal: Having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs. [NIH] Acceptor: A substance which, while normally not oxidized by oxygen or reduced by hydrogen, can be oxidized or reduced in presence of a substance which is itself undergoing oxidation or reduction. [NIH] Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak antiinflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. [NIH] Acetone: A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis. [NIH] Acetylcholine: A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications. [NIH] Acidemia: Increased acidity of blood. [NIH] Acidity: The quality of being acid or sour; containing acid (hydrogen ions). [EU] Acidosis: A pathologic condition resulting from accumulation of acid or depletion of the alkaline reserve (bicarbonate content) in the blood and body tissues, and characterized by an increase in hydrogen ion concentration. [EU] Acute renal: A condition in which the kidneys suddenly stop working. In most cases, kidneys can recover from almost complete loss of function. [NIH] Acyl: Chemical signal used by bacteria to communicate. [NIH] Adenosine: A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. [NIH] Adenovirus: A group of viruses that cause respiratory tract and eye infections. Adenoviruses used in gene therapy are altered to carry a specific tumor-fighting gene. [NIH] Aerobic: In biochemistry, reactions that need oxygen to happen or happen when oxygen is present. [NIH] Aerobic Metabolism: A chemical process in which oxygen is used to make energy from carbohydrates (sugars). Also known as aerobic respiration, oxidative metabolism, or cell respiration. [NIH] Aerobic Respiration: A chemical process in which oxygen is used to make energy from carbohydrates (sugars). Also known as oxidative metabolism, cell respiration, or aerobic metabolism. [NIH] Aetiology: Study of the causes of disease. [EU] Affinity: 1. Inherent likeness or relationship. 2. A special attraction for a specific element,

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organ, or structure. 3. Chemical affinity; the force that binds atoms in molecules; the tendency of substances to combine by chemical reaction. 4. The strength of noncovalent chemical binding between two substances as measured by the dissociation constant of the complex. 5. In immunology, a thermodynamic expression of the strength of interaction between a single antigen-binding site and a single antigenic determinant (and thus of the stereochemical compatibility between them), most accurately applied to interactions among simple, uniform antigenic determinants such as haptens. Expressed as the association constant (K litres mole -1), which, owing to the heterogeneity of affinities in a population of antibody molecules of a given specificity, actually represents an average value (mean intrinsic association constant). 6. The reciprocal of the dissociation constant. [EU] Aflatoxins: A group of closely related toxic metabolites that are designated mycotoxins. They are produced by Aspergillus flavus and A. parasiticus. Members of the group include aflatoxin B1, aflatoxin B2, aflatoxin G1, aflatoxin G2, aflatoxin M1, and aflatoxin M2. [NIH] Age Distribution: The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine. [NIH] Age Groups: Persons classified by age from birth (infant, newborn) to octogenarians and older (aged, 80 and over). [NIH] Aged, 80 and Over: A person 80 years of age and older. [NIH] Alkaline: Having the reactions of an alkali. [EU] Alternative medicine: Practices not generally recognized by the medical community as standard or conventional medical approaches and used instead of standard treatments. Alternative medicine includes the taking of dietary supplements, megadose vitamins, and herbal preparations; the drinking of special teas; and practices such as massage therapy, magnet therapy, spiritual healing, and meditation. [NIH] Amino acid: Any organic compound containing an amino (-NH2 and a carboxyl (- COOH) group. The 20 a-amino acids listed in the accompanying table are the amino acids from which proteins are synthesized by formation of peptide bonds during ribosomal translation of messenger RNA; all except glycine, which is not optically active, have the L configuration. Other amino acids occurring in proteins, such as hydroxyproline in collagen, are formed by posttranslational enzymatic modification of amino acids residues in polypeptide chains. There are also several important amino acids, such as the neurotransmitter y-aminobutyric acid, that have no relation to proteins. Abbreviated AA. [EU] Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining protein conformation. [NIH] Amiodarone: An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance. [NIH] Ammonia: A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. [NIH] Analgesic: An agent that alleviates pain without causing loss of consciousness. [EU] Anemia: A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin. [NIH] Animal model: An animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test

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new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models. [NIH] Antianginal: Counteracting angina or anginal conditions. [EU] Antiarrhythmic: An agent that prevents or alleviates cardiac arrhythmia. [EU] Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the antigen that induced their synthesis in cells of the lymphoid series (especially plasma cells), or with an antigen closely related to it. [NIH] Antibody: A type of protein made by certain white blood cells in response to a foreign substance (antigen). Each antibody can bind to only a specific antigen. The purpose of this binding is to help destroy the antigen. Antibodies can work in several ways, depending on the nature of the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen. [NIH] Antibody therapy: Treatment with an antibody, a substance that can directly kill specific tumor cells or stimulate the immune system to kill tumor cells. [NIH] Anticoagulant: A drug that helps prevent blood clots from forming. Also called a blood thinner. [NIH] Anticonvulsant: An agent that prevents or relieves convulsions. [EU] Antigen: Any substance which is capable, under appropriate conditions, of inducing a specific immune response and of reacting with the products of that response, that is, with specific antibody or specifically sensitized T-lymphocytes, or both. Antigens may be soluble substances, such as toxins and foreign proteins, or particulate, such as bacteria and tissue cells; however, only the portion of the protein or polysaccharide molecule known as the antigenic determinant (q.v.) combines with antibody or a specific receptor on a lymphocyte. Abbreviated Ag. [EU] Anti-infective: An agent that so acts. [EU] Anti-inflammatory: Having to do with reducing inflammation. [NIH] Anti-Inflammatory Agents: Substances that reduce or suppress inflammation. [NIH] Antipruritic: Relieving or preventing itching. [EU] Antipyretic: An agent that relieves or reduces fever. Called also antifebrile, antithermic and febrifuge. [EU] Anus: The opening of the rectum to the outside of the body. [NIH] Apolipoproteins: The protein components of lipoproteins which remain after the lipids to which the proteins are bound have been removed. They play an important role in lipid transport and metabolism. [NIH] Appendicitis: Acute inflammation of the vermiform appendix. [NIH] Apraxia: Loss of ability to perform purposeful movements, in the absence of paralysis or sensory disturbance, caused by lesions in the cortex. [NIH] Arginine: An essential amino acid that is physiologically active in the L-form. [NIH] Arterial: Pertaining to an artery or to the arteries. [EU] Arteries: The vessels carrying blood away from the heart. [NIH] Arteriosclerosis: Thickening and loss of elasticity of arterial walls. Atherosclerosis is the most common form of arteriosclerosis and involves lipid deposition and thickening of the intimal cell layers within arteries. Additional forms of arteriosclerosis involve calcification of the media of muscular arteries (Monkeberg medial calcific sclerosis) and thickening of the walls of small arteries or arterioles due to cell proliferation or hyaline deposition

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(arteriolosclerosis). [NIH] Aspartate: A synthetic amino acid. [NIH] Aspirin: A drug that reduces pain, fever, inflammation, and blood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention. [NIH] Assay: Determination of the amount of a particular constituent of a mixture, or of the biological or pharmacological potency of a drug. [EU] Astrocytes: The largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the blood brain barrier. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with microglia) respond to injury. Astrocytes have high- affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitter, but their role in signaling (as in many other functions) is not well understood. [NIH] Asymptomatic: Having no signs or symptoms of disease. [NIH] Atrial: Pertaining to an atrium. [EU] Atrial Fibrillation: Disorder of cardiac rhythm characterized by rapid, irregular atrial impulses and ineffective atrial contractions. [NIH] Atypical: Irregular; not conformable to the type; in microbiology, applied specifically to strains of unusual type. [EU] Auditory: Pertaining to the sense of hearing. [EU] Autodigestion: Autolysis; a condition found in disease of the stomach: the stomach wall is digested by the gastric juice. [NIH] Autoimmune Hepatitis: A liver disease caused when the body's immune system destroys liver cells for no known reason. [NIH] Autopsy: Postmortem examination of the body. [NIH] Avian: A plasmodial infection in birds. [NIH] Bacteria: Unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. [NIH] Base: In chemistry, the nonacid part of a salt; a substance that combines with acids to form salts; a substance that dissociates to give hydroxide ions in aqueous solutions; a substance whose molecule or ion can combine with a proton (hydrogen ion); a substance capable of donating a pair of electrons (to an acid) for the formation of a coordinate covalent bond. [EU] Bile: An emulsifying agent produced in the liver and secreted into the duodenum. Its composition includes bile acids and salts, cholesterol, and electrolytes. It aids digestion of fats in the duodenum. [NIH] Bile duct: A tube through which bile passes in and out of the liver. [NIH] Biliary: Having to do with the liver, bile ducts, and/or gallbladder. [NIH] Biliary Tract: The gallbladder and its ducts. [NIH] Bilirubin: A bile pigment that is a degradation product of heme. [NIH] Biochemical: Relating to biochemistry; characterized by, produced by, or involving chemical reactions in living organisms. [EU] Biological response modifier: BRM. A substance that stimulates the body's response to

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infection and disease. [NIH] Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body. [NIH] Biopsy specimen: Tissue removed from the body and examined under a microscope to determine whether disease is present. [NIH] Biotin: Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid. Growth factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.The biotin content of cancerous tissue is higher than that of normal tissue. [NIH] Bladder: The organ that stores urine. [NIH] Blood Coagulation: The process of the interaction of blood coagulation factors that results in an insoluble fibrin clot. [NIH] Blood pressure: The pressure of blood against the walls of a blood vessel or heart chamber. Unless there is reference to another location, such as the pulmonary artery or one of the heart chambers, it refers to the pressure in the systemic arteries, as measured, for example, in the forearm. [NIH] Blood vessel: A tube in the body through which blood circulates. Blood vessels include a network of arteries, arterioles, capillaries, venules, and veins. [NIH] Body Fluids: Liquid components of living organisms. [NIH] Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. [NIH] Brachial: All the nerves from the arm are ripped from the spinal cord. [NIH] Brachial Artery: The continuation of the axillary artery; it branches into the radial and ulnar arteries. [NIH] Bradykinin: A nonapeptide messenger that is enzymatically produced from kallidin in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from mast cells during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter. [NIH] Branch: Most commonly used for branches of nerves, but applied also to other structures. [NIH]

Breakdown: A physical, metal, or nervous collapse. [NIH] Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. [NIH] Camphor: A bicyclic monoterpene ketone found widely in plant (primarily the camphor tree, Cinnamomum camphora). Natural camphor is used topically as a skin antipruritic and as an anti-infective agent. [NIH] Carbamyl Phosphate: Phosphate salt of carbamic acid. [NIH]

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Carbohydrate: An aldehyde or ketone derivative of a polyhydric alcohol, particularly of the pentahydric and hexahydric alcohols. They are so named because the hydrogen and oxygen are usually in the proportion to form water, (CH2O)n. The most important carbohydrates are the starches, sugars, celluloses, and gums. They are classified into mono-, di-, tri-, polyand heterosaccharides. [EU] Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. [NIH] Cardiovascular: Having to do with the heart and blood vessels. [NIH] Cardiovascular disease: Any abnormal condition characterized by dysfunction of the heart and blood vessels. CVD includes atherosclerosis (especially coronary heart disease, which can lead to heart attacks), cerebrovascular disease (e.g., stroke), and hypertension (high blood pressure). [NIH] Carnitine: Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. [NIH] Carotene: The general name for a group of pigments found in green, yellow, and leafy vegetables, and yellow fruits. The pigments are fat-soluble, unsaturated aliphatic hydrocarbons functioning as provitamins and are converted to vitamin A through enzymatic processes in the intestinal wall. [NIH] Case report: A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin). [NIH] Catecholamines: tyrosine. [NIH]

A general class of ortho-dihydroxyphenylalkylamines derived from

Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from intubation in that the tube here is used to restore or maintain patency in obstructions. [NIH] Causal: Pertaining to a cause; directed against a cause. [EU] Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint. [NIH] Cell: The individual unit that makes up all of the tissues of the body. All living things are made up of one or more cells. [NIH] Cell membrane: Cell membrane = plasma membrane. The structure enveloping a cell, enclosing the cytoplasm, and forming a selective permeability barrier; it consists of lipids, proteins, and some carbohydrates, the lipids thought to form a bilayer in which integral proteins are embedded to varying degrees. [EU] Cell Respiration: The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell. [NIH] Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges. [NIH] Cerebellar: Pertaining to the cerebellum. [EU] Cerebellum: Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement. [NIH] Cerebral: Of or pertaining of the cerebrum or the brain. [EU] Cerebrospinal: Pertaining to the brain and spinal cord. [EU] Cerebrospinal fluid:

CSF. The fluid flowing around the brain and spinal cord.

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Cerebrospinal fluid is produced in the ventricles in the brain. [NIH] Cerebrum: The largest part of the brain. It is divided into two hemispheres, or halves, called the cerebral hemispheres. The cerebrum controls muscle functions of the body and also controls speech, emotions, reading, writing, and learning. [NIH] Chickenpox: A mild, highly contagious virus characterized by itchy blisters all over the body. [NIH] Chin: The anatomical frontal portion of the mandible, also known as the mentum, that contains the line of fusion of the two separate halves of the mandible (symphysis menti). This line of fusion divides inferiorly to enclose a triangular area called the mental protuberance. On each side, inferior to the second premolar tooth, is the mental foramen for the passage of blood vessels and a nerve. [NIH] Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. [NIH] Cholesterol Esters: Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis. [NIH] Choroid: The thin, highly vascular membrane covering most of the posterior of the eye between the retina and sclera. [NIH] Choroid Plexus: A villous structure of tangled masses of blood vessels contained within the third, lateral, and fourth ventricles of the brain. It regulates part of the production and composition of cerebrospinal fluid. [NIH] Chromatin: The material of chromosomes. It is a complex of DNA, histones, and nonhistone proteins (chromosomal proteins, non-histone) found within the nucleus of a cell. [NIH] Chronic: A disease or condition that persists or progresses over a long period of time. [NIH] Chylomicrons: A class of lipoproteins that carry dietary cholesterol and triglycerides from the small intestines to the tissues. [NIH] Circulatory system: The system that contains the heart and the blood vessels and moves blood throughout the body. This system helps tissues get enough oxygen and nutrients, and it helps them get rid of waste products. The lymph system, which connects with the blood system, is often considered part of the circulatory system. [NIH] Cirrhosis: A type of chronic, progressive liver disease. [NIH] CIS: Cancer Information Service. The CIS is the National Cancer Institute's link to the public, interpreting and explaining research findings in a clear and understandable manner, and providing personalized responses to specific questions about cancer. Access the CIS by calling 1-800-4-CANCER, or by using the Web site at http://cis.nci.nih.gov. [NIH] Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. [NIH] Clinical trial: A research study that tests how well new medical treatments or other interventions work in people. Each study is designed to test new methods of screening, prevention, diagnosis, or treatment of a disease. [NIH] Coagulation: 1. The process of clot formation. 2. In colloid chemistry, the solidification of a sol into a gelatinous mass; an alteration of a disperse phase or of a dissolved solid which causes the separation of the system into a liquid phase and an insoluble mass called the clot or curd. Coagulation is usually irreversible. 3. In surgery, the disruption of tissue by physical means to form an amorphous residuum, as in electrocoagulation and

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photocoagulation. [EU] Coenzyme: An organic nonprotein molecule, frequently a phosphorylated derivative of a water-soluble vitamin, that binds with the protein molecule (apoenzyme) to form the active enzyme (holoenzyme). [EU] Cofactor: A substance, microorganism or environmental factor that activates or enhances the action of another entity such as a disease-causing agent. [NIH] Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of skin, connective tissue, and the organic substance of bones and teeth. Different forms of collagen are produced in the body but all consist of three alpha-polypeptide chains arranged in a triple helix. Collagen is differentiated from other fibrous proteins, such as elastin, by the content of proline, hydroxyproline, and hydroxylysine; by the absence of tryptophan; and particularly by the high content of polar groups which are responsible for its swelling properties. [NIH] Collapse: 1. A state of extreme prostration and depression, with failure of circulation. 2. Abnormal falling in of the walls of any part of organ. [EU] Comatose: Pertaining to or affected with coma. [EU] Complement: A term originally used to refer to the heat-labile factor in serum that causes immune cytolysis, the lysis of antibody-coated cells, and now referring to the entire functionally related system comprising at least 20 distinct serum proteins that is the effector not only of immune cytolysis but also of other biologic functions. Complement activation occurs by two different sequences, the classic and alternative pathways. The proteins of the classic pathway are termed 'components of complement' and are designated by the symbols C1 through C9. C1 is a calcium-dependent complex of three distinct proteins C1q, C1r and C1s. The proteins of the alternative pathway (collectively referred to as the properdin system) and complement regulatory proteins are known by semisystematic or trivial names. Fragments resulting from proteolytic cleavage of complement proteins are designated with lower-case letter suffixes, e.g., C3a. Inactivated fragments may be designated with the suffix 'i', e.g. C3bi. Activated components or complexes with biological activity are designated by a bar over the symbol e.g. C1 or C4b,2a. The classic pathway is activated by the binding of C1 to classic pathway activators, primarily antigen-antibody complexes containing IgM, IgG1, IgG3; C1q binds to a single IgM molecule or two adjacent IgG molecules. The alternative pathway can be activated by IgA immune complexes and also by nonimmunologic materials including bacterial endotoxins, microbial polysaccharides, and cell walls. Activation of the classic pathway triggers an enzymatic cascade involving C1, C4, C2 and C3; activation of the alternative pathway triggers a cascade involving C3 and factors B, D and P. Both result in the cleavage of C5 and the formation of the membrane attack complex. Complement activation also results in the formation of many biologically active complement fragments that act as anaphylatoxins, opsonins, or chemotactic factors. [EU] Complementary and alternative medicine: CAM. Forms of treatment that are used in addition to (complementary) or instead of (alternative) standard treatments. These practices are not considered standard medical approaches. CAM includes dietary supplements, megadose vitamins, herbal preparations, special teas, massage therapy, magnet therapy, spiritual healing, and meditation. [NIH] Complementary medicine: Practices not generally recognized by the medical community as standard or conventional medical approaches and used to enhance or complement the standard treatments. Complementary medicine includes the taking of dietary supplements, megadose vitamins, and herbal preparations; the drinking of special teas; and practices such as massage therapy, magnet therapy, spiritual healing, and meditation. [NIH] Computational Biology: A field of biology concerned with the development of techniques

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for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories applicable to molecular biology and areas of computer-based techniques for solving biological problems including manipulation of models and datasets. [NIH] Cones: One type of specialized light-sensitive cells (photoreceptors) in the retina that provide sharp central vision and color vision. [NIH] Conjugated: Acting or operating as if joined; simultaneous. [EU] Conjunctiva: The mucous membrane that lines the inner surface of the eyelids and the anterior part of the sclera. [NIH] Connective Tissue: Tissue that supports and binds other tissues. It consists of connective tissue cells embedded in a large amount of extracellular matrix. [NIH] Connective Tissue: Tissue that supports and binds other tissues. It consists of connective tissue cells embedded in a large amount of extracellular matrix. [NIH] Consciousness: Sense of awareness of self and of the environment. [NIH] Constriction: The act of constricting. [NIH] Consumption: Pulmonary tuberculosis. [NIH] Contamination: The soiling or pollution by inferior material, as by the introduction of organisms into a wound, or sewage into a stream. [EU] Contraindications: Any factor or sign that it is unwise to pursue a certain kind of action or treatment, e. g. giving a general anesthetic to a person with pneumonia. [NIH] Convulsions: A general term referring to sudden and often violent motor activity of cerebral or brainstem origin. Convulsions may also occur in the absence of an electrical cerebral discharge (e.g., in response to hypotension). [NIH] Coronary: Encircling in the manner of a crown; a term applied to vessels; nerves, ligaments, etc. The term usually denotes the arteries that supply the heart muscle and, by extension, a pathologic involvement of them. [EU] Coronary Thrombosis: Presence of a thrombus in a coronary artery, often causing a myocardial infarction. [NIH] Cortex: The outer layer of an organ or other body structure, as distinguished from the internal substance. [EU] Cortical: Pertaining to or of the nature of a cortex or bark. [EU] Cranial: Pertaining to the cranium, or to the anterior (in animals) or superior (in humans) end of the body. [EU] Creatine: An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. [NIH]

Creatine Kinase: A transferase that catalyzes formation of phosphocreatine from ATP + creatine. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue, and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. EC 2.7.3.2. [NIH] Creatinine: A compound that is excreted from the body in urine. Creatinine levels are measured to monitor kidney function. [NIH] Critical Care: Health care provided to a critically ill patient during a medical emergency or crisis. [NIH]

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Cyclic: Pertaining to or occurring in a cycle or cycles; the term is applied to chemical compounds that contain a ring of atoms in the nucleus. [EU] Cytochrome: Any electron transfer hemoprotein having a mode of action in which the transfer of a single electron is effected by a reversible valence change of the central iron atom of the heme prosthetic group between the +2 and +3 oxidation states; classified as cytochromes a in which the heme contains a formyl side chain, cytochromes b, which contain protoheme or a closely similar heme that is not covalently bound to the protein, cytochromes c in which protoheme or other heme is covalently bound to the protein, and cytochromes d in which the iron-tetrapyrrole has fewer conjugated double bonds than the hemes have. Well-known cytochromes have been numbered consecutively within groups and are designated by subscripts (beginning with no subscript), e.g. cytochromes c, c1, C2, ... New cytochromes are named according to the wavelength in nanometres of the absorption maximum of the a-band of the iron (II) form in pyridine, e.g., c-555. [EU] Cytoplasm: The protoplasm of a cell exclusive of that of the nucleus; it consists of a continuous aqueous solution (cytosol) and the organelles and inclusions suspended in it (phaneroplasm), and is the site of most of the chemical activities of the cell. [EU] Deamination: The removal of an amino group (NH2) from a chemical compound. [NIH] Degenerative: Undergoing degeneration : tending to degenerate; having the character of or involving degeneration; causing or tending to cause degeneration. [EU] Delirium: (DSM III-R) an acute, reversible organic mental disorder characterized by reduced ability to maintain attention to external stimuli and disorganized thinking as manifested by rambling, irrelevant, or incoherent speech; there are also a reduced level of consciousness, sensory misperceptions, disturbance of the sleep-wakefulness cycle and level of psychomotor activity, disorientation to time, place, or person, and memory impairment. Delirium may be caused by a large number of conditions resulting in derangement of cerebral metabolism, including systemic infection, poisoning, drug intoxication or withdrawal, seizures or head trauma, and metabolic disturbances such as hypoxia, hypoglycaemia, fluid, electrolyte, or acid-base imbalances, or hepatic or renal failure. Called also acute confusional state and acute brain syndrome. [EU] Dendritic: 1. Branched like a tree. 2. Pertaining to or possessing dendrites. [EU] Dengue Virus: A species of the genus Flavivirus which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known. [NIH] Density: The logarithm to the base 10 of the opacity of an exposed and processed film. [NIH] Diabetes Mellitus: A heterogeneous group of disorders that share glucose intolerance in common. [NIH] Diabetic Ketoacidosis: Complication of diabetes resulting from severe insulin deficiency coupled with an absolute or relative increase in glucagon concentration. The metabolic acidosis is caused by the breakdown of adipose stores and resulting increased levels of free fatty acids. Glucagon accelerates the oxidation of the free fatty acids producing excess ketone bodies (ketosis). [NIH] Diagnostic procedure: A method used to identify a disease. [NIH] Dialyzer: A part of the hemodialysis machine. (See hemodialysis under dialysis.) The dialyzer has two sections separated by a membrane. One section holds dialysate. The other holds the patient's blood. [NIH] Diastolic: Of or pertaining to the diastole. [EU] Digestion: The process of breakdown of food for metabolism and use by the body. [NIH]

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Direct: 1. Straight; in a straight line. 2. Performed immediately and without the intervention of subsidiary means. [EU] Discrete: Made up of separate parts or characterized by lesions which do not become blended; not running together; separate. [NIH] Disorientation: The loss of proper bearings, or a state of mental confusion as to time, place, or identity. [EU] Dopamine: An endogenous catecholamine and prominent neurotransmitter in several systems of the brain. In the synthesis of catecholamines from tyrosine, it is the immediate precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of dopaminergic receptor subtypes mediate its action. Dopamine is used pharmacologically for its direct (beta adrenergic agonist) and indirect (adrenergic releasing) sympathomimetic effects including its actions as an inotropic agent and as a renal vasodilator. [NIH] Duct: A tube through which body fluids pass. [NIH] Edema: Excessive amount of watery fluid accumulated in the intercellular spaces, most commonly present in subcutaneous tissue. [NIH] Electrocoagulation: Electrosurgical procedures used to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. [NIH] Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. [NIH] Electrolyte: A substance that dissociates into ions when fused or in solution, and thus becomes capable of conducting electricity; an ionic solute. [EU] Electrophoresis: An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current. [NIH]

Elementary Particles: Individual components of atoms, usually subatomic; subnuclear particles are usually detected only when the atomic nucleus decays and then only transiently, as most of them are unstable, often yielding pure energy without substance, i.e., radiation. [NIH] Emboli: Bit of foreign matter which enters the blood stream at one point and is carried until it is lodged or impacted in an artery and obstructs it. It may be a blood clot, an air bubble, fat or other tissue, or clumps of bacteria. [NIH] Embolism: Blocking of a blood vessel by a blood clot or foreign matter that has been transported from a distant site by the blood stream. [NIH] Embolization: The blocking of an artery by a clot or foreign material. Embolization can be done as treatment to block the flow of blood to a tumor. [NIH] Emollient: Softening or soothing; called also malactic. [EU] Encephalitis: Inflammation of the brain due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see encephalitis, viral) are a relatively frequent cause of this condition. [NIH] Encephalitis, Viral: Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of Togaviridae infections; Herpesviridae infections; Adenoviridae infections; Flaviviridae infections; Bunyaviridae infections; Picornaviridae infections; Paramyxoviridae infections; Orthomyxoviridae infections; Retroviridae infections; and Arenaviridae infections. [NIH]

148 Reye’s Syndrome

Encephalopathy: A disorder of the brain that can be caused by disease, injury, drugs, or chemicals. [NIH] Endemic: Present or usually prevalent in a population or geographical area at all times; said of a disease or agent. Called also endemial. [EU] Endothelium: A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body. [NIH] Endothelium-derived: Small molecule that diffuses to the adjacent muscle layer and relaxes it. [NIH] Endotoxic: Of, relating to, or acting as an endotoxin (= a heat-stable toxin, associated with the outer membranes of certain gram-negative bacteria. Endotoxins are not secreted and are released only when the cells are disrupted). [EU] Endotoxin: Toxin from cell walls of bacteria. [NIH] Enteropeptidase: A specialized proteolytic enzyme secreted by intestinal cells. It converts trypsinogen into its active form trypsin by removing the N-terminal peptide. EC 3.4.21.9. [NIH]

Environmental Health: The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health. [NIH] Enzymatic: Phase where enzyme cuts the precursor protein. [NIH] Enzyme: A protein that speeds up chemical reactions in the body. [NIH] Epidemic: Occurring suddenly in numbers clearly in excess of normal expectancy; said especially of infectious diseases but applied also to any disease, injury, or other healthrelated event occurring in such outbreaks. [EU] Epidemiological: Relating to, or involving epidemiology. [EU] Epigastric: Having to do with the upper middle area of the abdomen. [NIH] Epithelial: Refers to the cells that line the internal and external surfaces of the body. [NIH] Epithelial Cells: Cells that line the inner and outer surfaces of the body. [NIH] Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing hemoglobin whose function is to transport oxygen. [NIH] Evoked Potentials: The electric response evoked in the central nervous system by stimulation of sensory receptors or some point on the sensory pathway leading from the receptor to the cortex. The evoked stimulus can be auditory, somatosensory, or visual, although other modalities have been reported. Event-related potentials is sometimes used synonymously with evoked potentials but is often associated with the execution of a motor, cognitive, or psychophysiological task, as well as with the response to a stimulus. [NIH] Exhaustion: The feeling of weariness of mind and body. [NIH] Exocrine: Secreting outwardly, via a duct. [EU] Expiration: The act of breathing out, or expelling air from the lungs. [EU] Extracellular: Outside a cell or cells. [EU] Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. [NIH] Eye Infections: Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation,

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visual impairment, or blindness. [NIH] Eye Movements: Voluntary or reflex-controlled movements of the eye. [NIH] Family Planning: Programs or services designed to assist the family in controlling reproduction by either improving or diminishing fertility. [NIH] Fat: Total lipids including phospholipids. [NIH] Fatty acids: A major component of fats that are used by the body for energy and tissue development. [NIH] Fatty Liver: The buildup of fat in liver cells. The most common cause is alcoholism. Other causes include obesity, diabetes, and pregnancy. Also called steatosis. [NIH] Febrile: Pertaining to or characterized by fever. [EU] Ferrets: Semidomesticated variety of European polecat much used for hunting rodents and/or rabbits and as a laboratory animal. [NIH] Fetus: The developing offspring from 7 to 8 weeks after conception until birth. [NIH] Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. [NIH] Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. [NIH] Forearm: The part between the elbow and the wrist. [NIH] Fourth Ventricle: An irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space. [NIH]

Gallbladder: The pear-shaped organ that sits below the liver. Bile is concentrated and stored in the gallbladder. [NIH] Gallstones: The solid masses or stones made of cholesterol or bilirubin that form in the gallbladder or bile ducts. [NIH] Gas: Air that comes from normal breakdown of food. The gases are passed out of the body through the rectum (flatus) or the mouth (burp). [NIH] Gas exchange: Primary function of the lungs; transfer of oxygen from inhaled air into the blood and of carbon dioxide from the blood into the lungs. [NIH] Gastric: Having to do with the stomach. [NIH] Gene: The functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein. [NIH]

Gene Therapy: The introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Techniques include insertion of retroviral vectors, transfection, homologous recombination, and injection of new genes into the nuclei of single cell embryos. The entire gene therapy process may consist of multiple steps. The new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia. [NIH] Gland: An organ that produces and releases one or more substances for use in the body. Some glands produce fluids that affect tissues or organs. Others produce hormones or

150 Reye’s Syndrome

participate in blood production. [NIH] Glomerular: Pertaining to or of the nature of a glomerulus, especially a renal glomerulus. [EU]

Glucose: D-Glucose. A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. [NIH] Glutamate: Excitatory neurotransmitter of the brain. [NIH] Glutamate Dehydrogenase: An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2. [NIH] Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid (glutamate) is the most common excitatory neurotransmitter in the central nervous system. [NIH] Glutamine: A non-essential amino acid present abundantly throught the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cells. [NIH] Glycerol: A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent. [NIH]

Glycine: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [NIH] Governing Board: The group in which legal authority is vested for the control of healthrelated institutions and organizations. [NIH] Grade: The grade of a tumor depends on how abnormal the cancer cells look under a microscope and how quickly the tumor is likely to grow and spread. Grading systems are different for each type of cancer. [NIH] Grading: A system for classifying cancer cells in terms of how abnormal they appear when examined under a microscope. The objective of a grading system is to provide information about the probable growth rate of the tumor and its tendency to spread. The systems used to grade tumors vary with each type of cancer. Grading plays a role in treatment decisions. [NIH]

Graft: Healthy skin, bone, or other tissue taken from one part of the body and used to replace diseased or injured tissue removed from another part of the body. [NIH] Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups: neutrophils, eosinophils, and basophils. [NIH] Growth: The progressive development of a living being or part of an organism from its earliest stage to maturity. [NIH] Guanylate Cyclase: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2. [NIH] Headache: Pain in the cranial region that may occur as an isolated and benign symptom or as a manifestation of a wide variety of conditions including subarachnoid hemorrhage; craniocerebral trauma; central nervous system infections; intracranial hypertension; and other disorders. In general, recurrent headaches that are not associated with a primary disease process are referred to as headache disorders (e.g., migraine). [NIH] Heart failure:

Loss of pumping ability by the heart, often accompanied by fatigue,

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breathlessness, and excess fluid accumulation in body tissues. [NIH] Heat Stroke: A condition characterized by cessation of sweating, hot dry skin, delirium, collapse, and coma and resulting from prolonged exposure to high environmental temperature. [NIH] Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins. [NIH] Hemochromatosis: A disease that occurs when the body absorbs too much iron. The body stores the excess iron in the liver, pancreas, and other organs. May cause cirrhosis of the liver. Also called iron overload disease. [NIH] Hemodialysis: The use of a machine to clean wastes from the blood after the kidneys have failed. The blood travels through tubes to a dialyzer, which removes wastes and extra fluid. The cleaned blood then flows through another set of tubes back into the body. [NIH] Hepatic: Refers to the liver. [NIH] Hepatic Encephalopathy: A condition that may cause loss of consciousness and coma. It is usually the result of advanced liver disease. Also called hepatic coma. [NIH] Hepatitis: Inflammation of the liver and liver disease involving degenerative or necrotic alterations of hepatocytes. [NIH] Hepatitis A: Hepatitis caused by hepatovirus. It can be transmitted through fecal contamination of food or water. [NIH] Hepatocellular: Pertaining to or affecting liver cells. [EU] Hepatocytes: The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. [NIH] Hepatotoxicity: How much damage a medicine or other substance does to the liver. [NIH] Hepatovirus: A genus of Picornaviridae causing infectious hepatitis naturally in humans and experimentally in other primates. It is transmitted through fecal contamination of food or water. [NIH] Heredity: 1. The genetic transmission of a particular quality or trait from parent to offspring. 2. The genetic constitution of an individual. [EU] Hormone: A substance in the body that regulates certain organs. Hormones such as gastrin help in breaking down food. Some hormones come from cells in the stomach and small intestine. [NIH] Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight 1. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are protons. Besides the common H1 isotope, hydrogen exists as the stable isotope deuterium and the unstable, radioactive isotope tritium. [NIH] Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water. [NIH] Hydrophobic: Not readily absorbing water, or being adversely affected by water, as a hydrophobic colloid. [EU] Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ascorbic acid can result in impaired hydroxyproline formation. [NIH] Hyperammonemia: blood. [NIH]

Metabolic disorder characterized by elevated level of ammonia in

Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions

152 Reye’s Syndrome

upon subsequent exposure to that particular antigen. [NIH] Hypertension: Persistently high arterial blood pressure. Currently accepted threshold levels are 140 mm Hg systolic and 90 mm Hg diastolic pressure. [NIH] Hyperventilation: A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide. [NIH] Hypoglycaemia: An abnormally diminished concentration of glucose in the blood, which may lead to tremulousness, cold sweat, piloerection, hypothermia, and headache, accompanied by irritability, confusion, hallucinations, bizarre behaviour, and ultimately, convulsions and coma. [EU] Hypoglycemia: Abnormally low blood sugar [NIH] Hypotension: Abnormally low blood pressure. [NIH] Hypotonic Solutions: Solutions that have a lesser osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid. [NIH] Hypoxia: Reduction of oxygen supply to tissue below physiological levels despite adequate perfusion of the tissue by blood. [EU] Ibuprofen: A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. [NIH] Id: The part of the personality structure which harbors the unconscious instinctive desires and strivings of the individual. [NIH] Idiopathic: Describes a disease of unknown cause. [NIH] Immune response: (antigens). [NIH]

The activity of the immune system against foreign substances

Immune system: The organs, cells, and molecules responsible for the recognition and disposal of foreign ("non-self") material which enters the body. [NIH] Immunogenic: Producing immunity; evoking an immune response. [EU] Impairment: In the context of health experience, an impairment is any loss or abnormality of psychological, physiological, or anatomical structure or function. [NIH] In vitro: In the laboratory (outside the body). The opposite of in vivo (in the body). [NIH] In vivo: In the body. The opposite of in vitro (outside the body or in the laboratory). [NIH] Indicative: That indicates; that points out more or less exactly; that reveals fairly clearly. [EU]

Infancy: The period of complete dependency prior to the acquisition of competence in walking, talking, and self-feeding. [NIH] Infant Mortality: Perinatal, neonatal, and infant deaths in a given population. [NIH] Infant, Newborn: An infant during the first month after birth. [NIH] Infarction: A pathological process consisting of a sudden insufficient blood supply to an area, which results in necrosis of that area. It is usually caused by a thrombus, an embolus, or a vascular torsion. [NIH] Infection: 1. Invasion and multiplication of microorganisms in body tissues, which may be clinically unapparent or result in local cellular injury due to competitive metabolism, toxins, intracellular replication, or antigen-antibody response. The infection may remain localized, subclinical, and temporary if the body's defensive mechanisms are effective. A local infection may persist and spread by extension to become an acute, subacute, or chronic

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clinical infection or disease state. A local infection may also become systemic when the microorganisms gain access to the lymphatic or vascular system. 2. An infectious disease. [EU]

Infectious Mononucleosis: A common, acute infection usually caused by the Epstein-Barr virus (Human herpesvirus 4). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis. [NIH] Infiltration: The diffusion or accumulation in a tissue or cells of substances not normal to it or in amounts of the normal. Also, the material so accumulated. [EU] Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. [NIH] Influenza: An acute viral infection involving the respiratory tract. It is marked by inflammation of the nasal mucosa, the pharynx, and conjunctiva, and by headache and severe, often generalized, myalgia. [NIH] Infusion: A method of putting fluids, including drugs, into the bloodstream. Also called intravenous infusion. [NIH] Ingestion: Taking into the body by mouth [NIH] Inhalation: The drawing of air or other substances into the lungs. [EU] Insulin: A protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus. [NIH] Insulin-dependent diabetes mellitus: A disease characterized by high levels of blood glucose resulting from defects in insulin secretion, insulin action, or both. Autoimmune, genetic, and environmental factors are involved in the development of type I diabetes. [NIH] Interferon: A biological response modifier (a substance that can improve the body's natural response to disease). Interferons interfere with the division of cancer cells and can slow tumor growth. There are several types of interferons, including interferon-alpha, -beta, and gamma. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases. [NIH] Interferon-alpha: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products. It is the major interferon produced by virus-induced leukocyte cultures and, in addition to its pronounced antiviral activity, it causes activation of NK cells. [NIH] Intermittent: Occurring at separated intervals; having periods of cessation of activity. [EU] Interstitial: Pertaining to or situated between parts or in the interspaces of a tissue. [EU] Intoxication: Poisoning, the state of being poisoned. [EU] Intracellular: Inside a cell. [NIH] Intracranial Hypertension: Increased pressure within the cranial vault. This may result from several conditions, including hydrocephalus; brain edema; intracranial masses; severe systemic hypertension; pseudotumor cerebri; and other disorders. [NIH] Intracranial Pressure: Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity. [NIH] Intravascular: Within a vessel or vessels. [EU] Intravenous: IV. Into a vein. [NIH]

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Intubation: Introduction of a tube into a hollow organ to restore or maintain patency if obstructed. It is differentiated from catheterization in that the insertion of a catheter is usually performed for the introducing or withdrawing of fluids from the body. [NIH] Ischemia: Deficiency of blood in a part, due to functional constriction or actual obstruction of a blood vessel. [EU] Isocitrate Dehydrogenase: An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key ratelimiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41. [NIH] Isoenzyme: Different forms of an enzyme, usually occurring in different tissues. The isoenzymes of a particular enzyme catalyze the same reaction but they differ in some of their properties. [NIH] Isoprenoid: Molecule that might anchor G protein to the cell membrane as it is hydrophobic. [NIH] Isotonic: A biological term denoting a solution in which body cells can be bathed without a net flow of water across the semipermeable cell membrane. Also, denoting a solution having the same tonicity as some other solution with which it is compared, such as physiologic salt solution and the blood serum. [EU] Joint: The point of contact between elements of an animal skeleton with the parts that surround and support it. [NIH] Kb: A measure of the length of DNA fragments, 1 Kb = 1000 base pairs. The largest DNA fragments are up to 50 kilobases long. [NIH] Ketoacidosis: Acidosis accompanied by the accumulation of ketone bodies (ketosis) in the body tissues and fluids, as in diabetic acidosis. [EU] Ketone Bodies: Chemicals that the body makes when there is not enough insulin in the blood and it must break down fat for its energy. Ketone bodies can poison and even kill body cells. When the body does not have the help of insulin, the ketones build up in the blood and then "spill" over into the urine so that the body can get rid of them. The body can also rid itself of one type of ketone, called acetone, through the lungs. This gives the breath a fruity odor. Ketones that build up in the body for a long time lead to serious illness and coma. [NIH] Ketosis: A condition of having ketone bodies build up in body tissues and fluids. The signs of ketosis are nausea, vomiting, and stomach pain. Ketosis can lead to ketoacidosis. [NIH] Kidney Disease: Any one of several chronic conditions that are caused by damage to the cells of the kidney. People who have had diabetes for a long time may have kidney damage. Also called nephropathy. [NIH] Kidney stone: A stone that develops from crystals that form in urine and build up on the inner surfaces of the kidney, in the renal pelvis, or in the ureters. [NIH] Kinetics: The study of rate dynamics in chemical or physical systems. [NIH] Lactulose: A mild laxative. [NIH] Large Intestine: The part of the intestine that goes from the cecum to the rectum. The large intestine absorbs water from stool and changes it from a liquid to a solid form. The large intestine is 5 feet long and includes the appendix, cecum, colon, and rectum. Also called colon. [NIH]

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Larva: Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals. [NIH] Laryngeal: Having to do with the larynx. [NIH] Larynx: An irregularly shaped, musculocartilaginous tubular structure, lined with mucous membrane, located at the top of the trachea and below the root of the tongue and the hyoid bone. It is the essential sphincter guarding the entrance into the trachea and functioning secondarily as the organ of voice. [NIH] Laxative: An agent that acts to promote evacuation of the bowel; a cathartic or purgative. [EU]

Leukocytes: White blood cells. These include granular leukocytes (basophils, eosinophils, and neutrophils) as well as non-granular leukocytes (lymphocytes and monocytes). [NIH] Library Services: circulation. [NIH]

Services offered to the library user. They include reference and

Ligase: An enzyme that repairs single stranded discontinuities in double-stranded DNA molecules in the cell. Purified DNA ligase is used in gene cloning to join DNA molecules together. [NIH] Lipid: Fat. [NIH] Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties. [NIH] Lipolysis: The hydrolysis of lipids. [NIH] Lipopolysaccharides: Substance consisting of polysaccaride and lipid. [NIH] Lipoprotein: Any of the lipid-protein complexes in which lipids are transported in the blood; lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesterol esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins; the four principal classes are high-density, low-density, and very-lowdensity lipoproteins and chylomicrons. [EU] Liver: A large, glandular organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile. [NIH] Liver cancer: A disease in which malignant (cancer) cells are found in the tissues of the liver. [NIH] Liver Mitochondria: Yellow discoloration of the liver due to fatty degeneration of liver parenchymal cells; the cause may be chemical poisoning. [NIH] Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another. [NIH] Localized: Cancer which has not metastasized yet. [NIH] Low-density lipoprotein: Lipoprotein that contains most of the cholesterol in the blood. LDL carries cholesterol to the tissues of the body, including the arteries. A high level of LDL increases the risk of heart disease. LDL typically contains 60 to 70 percent of the total serum cholesterol and both are directly correlated with CHD risk. [NIH] Lymphatic: The tissues and organs, including the bone marrow, spleen, thymus, and lymph nodes, that produce and store cells that fight infection and disease. [NIH] Lymphatic system: The tissues and organs that produce, store, and carry white blood cells that fight infection and other diseases. This system includes the bone marrow, spleen, thymus, lymph nodes and a network of thin tubes that carry lymph and white blood cells. These tubes branch, like blood vessels, into all the tissues of the body. [NIH]

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Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells. [NIH] Lymphoid: Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop. [NIH] Lysine: An essential amino acid. It is often added to animal feed. [NIH] Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. [NIH] Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (magnetic resonance imaging). [NIH] Malaria: A protozoan disease caused in humans by four species of the genus Plasmodium (P. falciparum (malaria, falciparum), P. vivax (malaria, vivax), P. ovale, and P. malariae) and transmitted by the bite of an infected female mosquito of the genus Anopheles. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high fever, sweating, shaking chills, and anemia. Malaria in animals is caused by other species of plasmodia. [NIH] Malaria, Falciparum: Malaria caused by Plasmodium falciparum. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations. [NIH] Malaria, Vivax: Malaria caused by Plasmodium vivax. This form of malaria is less severe than malaria, falciparum, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day. [NIH] Malignant: Cancerous; a growth with a tendency to invade and destroy nearby tissue and spread to other parts of the body. [NIH] Medical Records: illnesses. [NIH]

Recording of pertinent information concerning patient's illness or

MEDLINE: An online database of MEDLARS, the computerized bibliographic Medical Literature Analysis and Retrieval System of the National Library of Medicine. [NIH] Membrane: A very thin layer of tissue that covers a surface. [NIH] Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory. [NIH] Mental: Pertaining to the mind; psychic. 2. (L. mentum chin) pertaining to the chin. [EU] Mental Health: The state wherein the person is well adjusted. [NIH] Metabolic disorder: A condition in which normal metabolic processes are disrupted, usually because of a missing enzyme. [NIH] Metamorphosis: The ontogeny of insects, i. e. the series of changes undergone from egg, through larva and pupa, or through nymph, to adult. [NIH] MI: Myocardial infarction. Gross necrosis of the myocardium as a result of interruption of

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the blood supply to the area; it is almost always caused by atherosclerosis of the coronary arteries, upon which coronary thrombosis is usually superimposed. [NIH] Microbe: An organism which cannot be observed with the naked eye; e. g. unicellular animals, lower algae, lower fungi, bacteria. [NIH] Microbiology: The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses. [NIH] Microglia: The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling. [NIH] Micro-organism: An organism which cannot be observed with the naked eye; e. g. unicellular animals, lower algae, lower fungi, bacteria. [NIH] Mitochondria: Parts of a cell where aerobic production (also known as cell respiration) takes place. [NIH] Mitochondrial Swelling: Increase in volume of mitochondria due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria. [NIH] Modification: A change in an organism, or in a process in an organism, that is acquired from its own activity or environment. [NIH] Molecular: Of, pertaining to, or composed of molecules : a very small mass of matter. [EU] Molecule: A chemical made up of two or more atoms. The atoms in a molecule can be the same (an oxygen molecule has two oxygen atoms) or different (a water molecule has two hydrogen atoms and one oxygen atom). Biological molecules, such as proteins and DNA, can be made up of many thousands of atoms. [NIH] Monoamine: Enzyme that breaks down dopamine in the astrocytes and microglia. [NIH] Monoamine Oxidase: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4. [NIH] Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles. [NIH] Mononuclear: A cell with one nucleus. [NIH] Mononucleosis: The presence of an abnormally large number of mononuclear leucocytes (monocytes) in the blood. The term is often used alone to refer to infectious mononucleosis. [EU]

Morphology: The science of the form and structure of organisms (plants, animals, and other forms of life). [NIH] Motor Activity: The physical activity of an organism as a behavioral phenomenon. [NIH]

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Myalgia: Pain in a muscle or muscles. [EU] Mycotoxins: Toxins derived from bacteria or fungi. [NIH] Myocardial infarction: Gross necrosis of the myocardium as a result of interruption of the blood supply to the area; it is almost always caused by atherosclerosis of the coronary arteries, upon which coronary thrombosis is usually superimposed. [NIH] Myocarditis: Inflammation of the myocardium; inflammation of the muscular walls of the heart. [EU] Myocardium: The muscle tissue of the heart composed of striated, involuntary muscle known as cardiac muscle. [NIH] Myopathy: Any disease of a muscle. [EU] Nasal Mucosa: The mucous membrane lining the nasal cavity. [NIH] Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses. [NIH] Need: A state of tension or dissatisfaction felt by an individual that impels him to action toward a goal he believes will satisfy the impulse. [NIH] Neonatal: Pertaining to the first four weeks after birth. [EU] Neoplasm: A new growth of benign or malignant tissue. [NIH] Nephropathy: Disease of the kidneys. [EU] Nerve: A cordlike structure of nervous tissue that connects parts of the nervous system with other tissues of the body and conveys nervous impulses to, or away from, these tissues. [NIH] Nervous System: The entire nerve apparatus composed of the brain, spinal cord, nerves and ganglia. [NIH] Neural: 1. Pertaining to a nerve or to the nerves. 2. Situated in the region of the spinal axis, as the neutral arch. [EU] Neurologic: Having to do with nerves or the nervous system. [NIH] Neurotransmitter: Any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, norepinephrine, epinephrine, dopamine, glycine, y-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins, and serotonin. [EU] Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells. It is synthesized from arginine by a complex reaction, catalyzed by nitric oxide synthase. Nitric oxide is endothelium-derived relaxing factor. It is released by the vascular endothelium and mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic guanylate cyclase and thus elevates intracellular levels of cyclic GMP. [NIH]

Nitrogen: An element with the atomic symbol N, atomic number 7, and atomic weight 14. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells. [NIH] Nuclei: A body of specialized protoplasm found in nearly all cells and containing the chromosomes. [NIH]

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Nucleic acid: Either of two types of macromolecule (DNA or RNA) formed by polymerization of nucleotides. Nucleic acids are found in all living cells and contain the information (genetic code) for the transfer of genetic information from one generation to the next. [NIH] Nucleus: A body of specialized protoplasm found in nearly all cells and containing the chromosomes. [NIH] Nymph: The immature stage in the life cycle of those orders of insects characterized by gradual metamorphosis, in which the young resemble the imago in general form of body, including compound eyes and external wings; also the 8-legged stage of mites and ticks that follows the first moult. [NIH] Ocular: 1. Of, pertaining to, or affecting the eye. 2. Eyepiece. [EU] Oedema: The presence of abnormally large amounts of fluid in the intercellular tissue spaces of the body; usually applied to demonstrable accumulation of excessive fluid in the subcutaneous tissues. Edema may be localized, due to venous or lymphatic obstruction or to increased vascular permeability, or it may be systemic due to heart failure or renal disease. Collections of edema fluid are designated according to the site, e.g. ascites (peritoneal cavity), hydrothorax (pleural cavity), and hydropericardium (pericardial sac). Massive generalized edema is called anasarca. [EU] Ophthalmic: Pertaining to the eye. [EU] Opsin: A protein formed, together with retinene, by the chemical breakdown of metarhodopsin. [NIH] Optic Nerve: The 2nd cranial nerve. The optic nerve conveys visual information from the retina to the brain. The nerve carries the axons of the retinal ganglion cells which sort at the optic chiasm and continue via the optic tracts to the brain. The largest projection is to the lateral geniculate nuclei; other important targets include the superior colliculi and the suprachiasmatic nuclei. Though known as the second cranial nerve, it is considered part of the central nervous system. [NIH] Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species. [NIH] Ornithine: An amino acid produced in the urea cycle by the splitting off of urea from arginine. [NIH] Osmolality: The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per kilogram of solvent. The osmolality is directly proportional to the colligative properties of solutions; osmotic pressure, boiling point elevation, freezing point depression, and vapour pressure lowering. [EU] Osmoles: The standard unit of osmotic pressure. [NIH] Osmotic: Pertaining to or of the nature of osmosis (= the passage of pure solvent from a solution of lesser to one of greater solute concentration when the two solutions are separated by a membrane which selectively prevents the passage of solute molecules, but is permeable to the solvent). [EU] Oxidation: The act of oxidizing or state of being oxidized. Chemically it consists in the increase of positive charges on an atom or the loss of negative charges. Most biological oxidations are accomplished by the removal of a pair of hydrogen atoms (dehydrogenation) from a molecule. Such oxidations must be accompanied by reduction of an acceptor molecule. Univalent o. indicates loss of one electron; divalent o., the loss of two electrons. [EU]

Oxidative metabolism: A chemical process in which oxygen is used to make energy from

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carbohydrates (sugars). Also known as aerobic respiration, cell respiration, or aerobic metabolism. [NIH] Oxygen Consumption: The oxygen consumption is determined by calculating the difference between the amount of oxygen inhaled and exhaled. [NIH] Pancreas: A mixed exocrine and endocrine gland situated transversely across the posterior abdominal wall in the epigastric and hypochondriac regions. The endocrine portion is comprised of the Islets of Langerhans, while the exocrine portion is a compound acinar gland that secretes digestive enzymes. [NIH] Pancreatic: Having to do with the pancreas. [NIH] Pancreatitis: Acute or chronic inflammation of the pancreas, which may be asymptomatic or symptomatic, and which is due to autodigestion of a pancreatic tissue by its own enzymes. It is caused most often by alcoholism or biliary tract disease; less commonly it may be associated with hyperlipaemia, hyperparathyroidism, abdominal trauma (accidental or operative injury), vasculitis, or uraemia. [EU] Paralysis: Loss of ability to move all or part of the body. [NIH] Pathogenesis: The cellular events and reactions that occur in the development of disease. [NIH]

Pathologic: 1. Indicative of or caused by a morbid condition. 2. Pertaining to pathology (= branch of medicine that treats the essential nature of the disease, especially the structural and functional changes in tissues and organs of the body caused by the disease). [EU] Pathophysiology: Altered functions in an individual or an organ due to disease. [NIH] Peptide: Any compound consisting of two or more amino acids, the building blocks of proteins. Peptides are combined to make proteins. [NIH] Peritoneal: Having to do with the peritoneum (the tissue that lines the abdominal wall and covers most of the organs in the abdomen). [NIH] Peritoneal Cavity: The space enclosed by the peritoneum. It is divided into two portions, the greater sac and the lesser sac or omental bursa, which lies behind the stomach. The two sacs are connected by the foramen of Winslow, or epiploic foramen. [NIH] Peritoneal Dialysis: Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure. [NIH] Peritoneum: Endothelial lining of the abdominal cavity, the parietal peritoneum covering the inside of the abdominal wall and the visceral peritoneum covering the bowel, the mesentery, and certain of the organs. The portion that covers the bowel becomes the serosal layer of the bowel wall. [NIH] Pharmacologic: Pertaining to pharmacology or to the properties and reactions of drugs. [EU] Pharynx: The hollow tube about 5 inches long that starts behind the nose and ends at the top of the trachea (windpipe) and esophagus (the tube that goes to the stomach). [NIH] Phosphodiesterase: Effector enzyme that regulates the levels of a second messenger, the cyclic GMP. [NIH] Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides; glycerophospholipids) or sphingosine (sphingolipids). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system. [NIH] Phosphorus: A non-metallic element that is found in the blood, muscles, nevers, bones, and teeth, and is a component of adenosine triphosphate (ATP; the primary energy source for

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the body's cells.) [NIH] Phosphorylated: Attached to a phosphate group. [NIH] Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety. [NIH] Photocoagulation: Using a special strong beam of light (laser) to seal off bleeding blood vessels such as in the eye. The laser can also burn away blood vessels that should not have grown in the eye. This is the main treatment for diabetic retinopathy. [NIH] Pigments: Any normal or abnormal coloring matter in plants, animals, or micro-organisms. [NIH]

Plague: An acute infectious disease caused by Yersinia pestis that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form. [NIH] Plants: Multicellular, eukaryotic life forms of the kingdom Plantae. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (meristems); cellulose within cells providing rigidity; the absence of organs of locomotion; absense of nervous and sensory systems; and an alteration of haploid and diploid generations. [NIH] Plasma: The clear, yellowish, fluid part of the blood that carries the blood cells. The proteins that form blood clots are in plasma. [NIH] Plasma cells: A type of white blood cell that produces antibodies. [NIH] Platelet Aggregation: The attachment of platelets to one another. This clumping together can be induced by a number of agents (e.g., thrombin, collagen) and is part of the mechanism leading to the formation of a thrombus. [NIH] Platelets: A type of blood cell that helps prevent bleeding by causing blood clots to form. Also called thrombocytes. [NIH] Pleural: A circumscribed area of hyaline whorled fibrous tissue which appears on the surface of the parietal pleura, on the fibrous part of the diaphragm or on the pleura in the interlobar fissures. [NIH] Pleural cavity: A space enclosed by the pleura (thin tissue covering the lungs and lining the interior wall of the chest cavity). It is bound by thin membranes. [NIH] Pneumonia: Inflammation of the lungs. [NIH] Poisoning: A condition or physical state produced by the ingestion, injection or inhalation of, or exposure to a deleterious agent. [NIH] Polyunsaturated fat: An unsaturated fat found in greatest amounts in foods derived from plants, including safflower, sunflower, corn, and soybean oils. [NIH] Pontine: A brain region involved in the detection and processing of taste. [NIH] Porphyria: A group of disorders characterized by the excessive production of porphyrins or their precursors that arises from abnormalities in the regulation of the porphyrin-heme pathway. The porphyrias are usually divided into three broad groups, erythropoietic, hepatic, and erythrohepatic, according to the major sites of abnormal porphyrin synthesis. [NIH]

Porphyrins: A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component

162 Reye’s Syndrome

in biologically significant compounds such as hemoglobin and myoglobin. [NIH] Posterior: Situated in back of, or in the back part of, or affecting the back or dorsal surface of the body. In lower animals, it refers to the caudal end of the body. [EU] Postnatal: Occurring after birth, with reference to the newborn. [EU] Practice Guidelines: Directions or principles presenting current or future rules of policy for the health care practitioner to assist him in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery. [NIH] Prealbumin: A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease. [NIH] Prenatal: Existing or occurring before birth, with reference to the fetus. [EU] Presumptive: A treatment based on an assumed diagnosis, prior to receiving confirmatory laboratory test results. [NIH] Primary Biliary Cirrhosis: A chronic liver disease. Slowly destroys the bile ducts in the liver. This prevents release of bile. Long-term irritation of the liver may cause scarring and cirrhosis in later stages of the disease. [NIH] Progression: Increase in the size of a tumor or spread of cancer in the body. [NIH] Progressive: Advancing; going forward; going from bad to worse; increasing in scope or severity. [EU] Prophylaxis: An attempt to prevent disease. [NIH] Proportional: Being in proportion : corresponding in size, degree, or intensity, having the same or a constant ratio; of, relating to, or used in determining proportions. [EU] Protein C: A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation. [NIH] Protein Folding: A rapid biochemical reaction involved in the formation of proteins. It begins even before a protein has been completely synthesized and proceeds through discrete intermediates (primary, secondary, and tertiary structures) before the final structure (quaternary structure) is developed. [NIH] Protein S: The vitamin K-dependent cofactor of activated protein C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S can lead to recurrent venous and arterial thrombosis. [NIH] Proteins: Polymers of amino acids linked by peptide bonds. The specific sequence of amino acids determines the shape and function of the protein. [NIH] Protocol: The detailed plan for a clinical trial that states the trial's rationale, purpose, drug or vaccine dosages, length of study, routes of administration, who may participate, and other aspects of trial design. [NIH] Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion. [NIH] Protozoan: 1. Any individual of the protozoa; protozoon. 2. Of or pertaining to the protozoa; protozoal. [EU]

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Pseudotumor Cerebri: A condition marked by raised intracranial pressure and characterized clinically by headaches; nausea; papilledema, peripheral constriction of the visual fields, transient visual obscurations, and pulsatile tinnitus. Obesity is frequently associated with this condition, which primarily affects women between 20 and 44 years of age. Chronic papilledema may lead to optic nerve injury (optic nerve diseases) and visual loss (blindness). [NIH] Psychic: Pertaining to the psyche or to the mind; mental. [EU] Psychomotor: Pertaining to motor effects of cerebral or psychic activity. [EU] Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level. [NIH] Public Policy: A course or method of action selected, usually by a government, from among alternatives to guide and determine present and future decisions. [NIH] Pulmonary: Relating to the lungs. [NIH] Pulmonary Embolism: Embolism in the pulmonary artery or one of its branches. [NIH] Pulmonary Ventilation: The total volume of gas per minute inspired or expired measured in liters per minute. [NIH] Pupa: An inactive stage between the larval and adult stages in the life cycle of insects. [NIH] Pyogenic: Producing pus; pyopoietic (= liquid inflammation product made up of cells and a thin fluid called liquor puris). [EU] Pyridoxal: 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4- pyridinecarboxaldehyde. [NIH] Pyruvate Carboxylase: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of carbon dioxide to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and lactic acidosis in infants. EC 6.4.1.1. [NIH] Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment. [NIH] Quaternary: 1. Fourth in order. 2. Containing four elements or groups. [EU] Radial Artery: The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand. [NIH] Radius: The lateral bone of the forearm. [NIH] Receptor: A molecule inside or on the surface of a cell that binds to a specific substance and causes a specific physiologic effect in the cell. [NIH] Rectal: By or having to do with the rectum. The rectum is the last 8 to 10 inches of the large intestine and ends at the anus. [NIH] Rectum: The last 8 to 10 inches of the large intestine. [NIH] Refer: To send or direct for treatment, aid, information, de decision. [NIH] Reflex: An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord. [NIH] Refractory: Not readily yielding to treatment. [EU] Renal failure: Progressive renal insufficiency and uremia, due to irreversible and progressive renal glomerular tubular or interstitial disease. [NIH]

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Respiration: The act of breathing with the lungs, consisting of inspiration, or the taking into the lungs of the ambient air, and of expiration, or the expelling of the modified air which contains more carbon dioxide than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= oxygen consumption) or cell respiration (= cell respiration). [NIH] Respiratory distress syndrome: A lung disease that occurs primarily in premature infants; the newborn must struggle for each breath and blueing of its skin reflects the baby's inability to get enough oxygen. [NIH] Respiratory failure: Inability of the lungs to conduct gas exchange. [NIH] Respiratory syncytial virus: RSV. A virus that causes respiratory infections with cold-like symptoms. [NIH] Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the optic nerve and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the choroid and the inner surface with the vitreous body. The outer-most layer is pigmented, whereas the inner nine layers are transparent. [NIH] Retinal: 1. Pertaining to the retina. 2. The aldehyde of retinol, derived by the oxidative enzymatic splitting of absorbed dietary carotene, and having vitamin A activity. In the retina, retinal combines with opsins to form visual pigments. One isomer, 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin, or visual purple. Another, all-trans retinal (trans-r.); visual yellow; xanthopsin) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal also combines with opsins in the cones (photopsins) to form the three pigments responsible for colour vision. Called also retinal, and retinene1. [EU] Retinal Vein: Central retinal vein and its tributaries. It runs a short course within the optic nerve and then leaves and empties into the superior ophthalmic vein or cavernous sinus. [NIH]

Retinal Vein Occlusion: Occlusion of the retinal vein. Those at high risk for this condition include patients with hypertension, diabetes mellitus, arteriosclerosis, and other cardiovascular diseases. [NIH] Retinol: Vitamin A. It is essential for proper vision and healthy skin and mucous membranes. Retinol is being studied for cancer prevention; it belongs to the family of drugs called retinoids. [NIH] Retrospective: Looking back at events that have already taken place. [NIH] Retrospective study: A study that looks backward in time, usually using medical records and interviews with patients who already have or had a disease. [NIH] Rheumatism: A group of disorders marked by inflammation or pain in the connective tissue structures of the body. These structures include bone, cartilage, and fat. [NIH] Rheumatoid: Resembling rheumatism. [EU] Rheumatoid arthritis: A form of arthritis, the cause of which is unknown, although infection, hypersensitivity, hormone imbalance and psychologic stress have been suggested as possible causes. [NIH] Rhodopsin: A photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinal, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. [NIH] Rigidity: Stiffness or inflexibility, chiefly that which is abnormal or morbid; rigor. [EU] Risk factor: A habit, trait, condition, or genetic alteration that increases a person's chance of

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developing a disease. [NIH] Salicylate: Non-steroidal anti-inflammatory drugs. [NIH] Salicylic: A tuberculosis drug. [NIH] Salicylism: A group of commonly occurring toxic effects of excessive dosage with salicylic acid or its salts, usually marked by tinnitus, nausea, and vomiting. [EU] Sclera: The tough white outer coat of the eyeball, covering approximately the posterior fivesixths of its surface, and continuous anteriorly with the cornea and posteriorly with the external sheath of the optic nerve. [EU] Screening: Checking for disease when there are no symptoms. [NIH] Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as epilepsy or "seizure disorder." [NIH] Septicaemia: A term originally used to denote a putrefactive process in the body, but now usually referring to infection with pyogenic micro-organisms; a genus of Diptera; the severe type of infection in which the blood stream is invaded by large numbers of the causal. [NIH] Sequela: Any lesion or affection following or caused by an attack of disease. [EU] Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines, pyrimidines, and other amino acids. [NIH] Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-tryptophan. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (receptors, serotonin) explain the broad physiological actions and distribution of this biochemical mediator. [NIH] Serotypes: A cause of haemorrhagic septicaemia (in cattle, sheep and pigs), fowl cholera of birds, pasteurellosis of rabbits, and gangrenous mastitis of ewes. It is also commonly found in atrophic rhinitis of pigs. [NIH] Serum: The clear liquid part of the blood that remains after blood cells and clotting proteins have been removed. [NIH] Serum Albumin: A major plasma protein that serves in maintaining the plasma colloidal osmotic pressure and transporting large organic anions. [NIH] Side effect: A consequence other than the one(s) for which an agent or measure is used, as the adverse effects produced by a drug, especially on a tissue or organ system other than the one sought to be benefited by its administration. [EU] Skeletal: Having to do with the skeleton (boney part of the body). [NIH] Skeleton: The framework that supports the soft tissues of vertebrate animals and protects many of their internal organs. The skeletons of vertebrates are made of bone and/or cartilage. [NIH] Skull: The skeleton of the head including the bones of the face and the bones enclosing the brain. [NIH] Small intestine: The part of the digestive tract that is located between the stomach and the large intestine. [NIH] Sodium: An element that is a member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. With a valence of 1, it has a strong

166 Reye’s Syndrome

affinity for oxygen and other nonmetallic elements. Sodium provides the chief cation of the extracellular body fluids. Its salts are the most widely used in medicine. (From Dorland, 27th ed) Physiologically the sodium ion plays a major role in blood pressure regulation, maintenance of fluid volume, and electrolyte balance. [NIH] Sodium Channels: Cell membrane glycoproteins selective for sodium ions. Fast sodium current is associated with the action potential in neural membranes. [NIH] Soft tissue: Refers to muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body. [NIH] Solvent: 1. Dissolving; effecting a solution. 2. A liquid that dissolves or that is capable of dissolving; the component of a solution that is present in greater amount. [EU] Soybean Oil: Oil from soybean or soybean plant. [NIH] Specialist: In medicine, one who concentrates on 1 special branch of medical science. [NIH] Species: A taxonomic category subordinate to a genus (or subgenus) and superior to a subspecies or variety, composed of individuals possessing common characters distinguishing them from other categories of individuals of the same taxonomic level. In taxonomic nomenclature, species are designated by the genus name followed by a Latin or Latinized adjective or noun. [EU] Spike: The activation of synapses causes changes in the permeability of the dendritic membrane leading to changes in the membrane potential. This difference of the potential travels along the axon of the neuron and is called spike. [NIH] Spleen: An organ that is part of the lymphatic system. The spleen produces lymphocytes, filters the blood, stores blood cells, and destroys old blood cells. It is located on the left side of the abdomen near the stomach. [NIH] Steatosis: Fatty degeneration. [EU] Steroids: Drugs used to relieve swelling and inflammation. [NIH] Stimulus: That which can elicit or evoke action (response) in a muscle, nerve, gland or other excitable issue, or cause an augmenting action upon any function or metabolic process. [NIH] Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the esophagus and the beginning of the duodenum. [NIH] Stress: Forcibly exerted influence; pressure. Any condition or situation that causes strain or tension. Stress may be either physical or psychologic, or both. [NIH] Subacute: Somewhat acute; between acute and chronic. [EU] Subclinical: Without clinical manifestations; said of the early stage(s) of an infection or other disease or abnormality before symptoms and signs become apparent or detectable by clinical examination or laboratory tests, or of a very mild form of an infection or other disease or abnormality. [EU] Subcutaneous: Beneath the skin. [NIH] Subspecies: A category intermediate in rank between species and variety, based on a smaller number of correlated characters than are used to differentiate species and generally conditioned by geographical and/or ecological occurrence. [NIH] Supplementation: Adding nutrients to the diet. [NIH] Support group: A group of people with similar disease who meet to discuss how better to cope with their cancer and treatment. [NIH] Supportive care: Treatment given to prevent, control, or relieve complications and side effects and to improve the comfort and quality of life of people who have cancer. [NIH]

Dictionary 167

Symptomatic: Having to do with symptoms, which are signs of a condition or disease. [NIH] Synapses: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate through direct electrical connections which are sometimes called electrical synapses; these are not included here but rather in gap junctions. [NIH] Systemic: Affecting the entire body. [NIH] Systolic: Indicating the maximum arterial pressure during contraction of the left ventricle of the heart. [EU] Threshold: For a specified sensory modality (e. g. light, sound, vibration), the lowest level (absolute threshold) or smallest difference (difference threshold, difference limen) or intensity of the stimulus discernible in prescribed conditions of stimulation. [NIH] Thrombosis: The formation or presence of a blood clot inside a blood vessel. [NIH] Tidal Volume: The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T. [NIH] Tinnitus: Sounds that are perceived in the absence of any external noise source which may take the form of buzzing, ringing, clicking, pulsations, and other noises. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of cochlear diseases; vestibulocochlear nerve diseases; intracranial hypertension; craniocerebral trauma; and other conditions. [NIH] Tissue: A group or layer of cells that are alike in type and work together to perform a specific function. [NIH] Tomography: Imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane. [NIH] Toxic: Having to do with poison or something harmful to the body. Toxic substances usually cause unwanted side effects. [NIH] Toxicity: The quality of being poisonous, especially the degree of virulence of a toxic microbe or of a poison. [EU] Toxicology: The science concerned with the detection, chemical composition, and pharmacologic action of toxic substances or poisons and the treatment and prevention of toxic manifestations. [NIH] Toxins: Specific, characterizable, poisonous chemicals, often proteins, with specific biological properties, including immunogenicity, produced by microbes, higher plants, or animals. [NIH] Transfusion: The infusion of components of blood or whole blood into the bloodstream. The blood may be donated from another person, or it may have been taken from the person earlier and stored until needed. [NIH] Translation: The process whereby the genetic information present in the linear sequence of ribonucleotides in mRNA is converted into a corresponding sequence of amino acids in a protein. It occurs on the ribosome and is unidirectional. [NIH] Transplantation: Transference of a tissue or organ, alive or dead, within an individual, between individuals of the same species, or between individuals of different species. [NIH]

168 Reye’s Syndrome

Trauma: Any injury, wound, or shock, must frequently physical or structural shock, producing a disturbance. [NIH] Triglyceride: A lipid carried through the blood stream to tissues. Most of the body's fat tissue is in the form of triglycerides, stored for use as energy. Triglycerides are obtained primarily from fat in foods. [NIH] Trypsin: A serine endopeptidase that is formed from trypsinogen in the pancreas. It is converted into its active form by enteropeptidase in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4. [NIH] Tumour: 1. Swelling, one of the cardinal signs of inflammations; morbid enlargement. 2. A new growth of tissue in which the multiplication of cells is uncontrolled and progressive; called also neoplasm. [EU] Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems. [NIH] Ulcer: A localized necrotic lesion of the skin or a mucous surface. [NIH] Unconscious: Experience which was once conscious, but was subsequently rejected, as the "personal unconscious". [NIH] Uraemia: 1. An excess in the blood of urea, creatinine, and other nitrogenous end products of protein and amino acids metabolism; more correctly referred to as azotemia. 2. In current usage the entire constellation of signs and symptoms of chronic renal failure, including nausea, vomiting anorexia, a metallic taste in the mouth, a uraemic odour of the breath, pruritus, uraemic frost on the skin, neuromuscular disorders, pain and twitching in the muscles, hypertension, edema, mental confusion, and acid-base and electrolyte imbalances. [EU]

Urea: A compound (CO(NH2)2), formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. [NIH] Uremia: The illness associated with the buildup of urea in the blood because the kidneys are not working effectively. Symptoms include nausea, vomiting, loss of appetite, weakness, and mental confusion. [NIH] Urethra: The tube through which urine leaves the body. It empties urine from the bladder. [NIH]

Uric: A kidney stone that may result from a diet high in animal protein. When the body breaks down this protein, uric acid levels rise and can form stones. [NIH] Urinary: Having to do with urine or the organs of the body that produce and get rid of urine. [NIH] Urine: Fluid containing water and waste products. Urine is made by the kidneys, stored in the bladder, and leaves the body through the urethra. [NIH] Vaccine: A substance or group of substances meant to cause the immune system to respond to a tumor or to microorganisms, such as bacteria or viruses. [NIH] Valproic Acid: A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GABA levels in the brain or by altering the properties of voltage dependent sodium channels. [NIH] Valves: Flap-like structures that control the direction of blood flow through the heart. [NIH]

Dictionary 169

Varicella: Chicken pox. [EU] Vascular: Pertaining to blood vessels or indicative of a copious blood supply. [EU] Vascular Resistance: An expression of the resistance offered by the systemic arterioles, and to a lesser extent by the capillaries, to the flow of blood. [NIH] Vasculitis: Inflammation of a blood vessel. [NIH] Vasodilatation: A state of increased calibre of the blood vessels. [EU] Vasodilators: Any nerve or agent which induces dilatation of the blood vessels. [NIH] Vein: Vessel-carrying blood from various parts of the body to the heart. [NIH] Venous: Of or pertaining to the veins. [EU] Venous Thrombosis: The formation or presence of a thrombus within a vein. [NIH] Ventricular: Pertaining to a ventricle. [EU] Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals. [NIH] Villous: Of a surface, covered with villi. [NIH] Viral: Pertaining to, caused by, or of the nature of virus. [EU] Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. [NIH] Virus: Submicroscopic organism that causes infectious disease. In cancer therapy, some viruses may be made into vaccines that help the body build an immune response to, and kill, tumor cells. [NIH] Viscera: Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen. [NIH] Vitro: Descriptive of an event or enzyme reaction under experimental investigation occurring outside a living organism. Parts of an organism or microorganism are used together with artificial substrates and/or conditions. [NIH] Vivo: Outside of or removed from the body of a living organism. [NIH] Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide. [NIH] White blood cell: A type of cell in the immune system that helps the body fight infection and disease. White blood cells include lymphocytes, granulocytes, macrophages, and others. [NIH]

Withdrawal: 1. A pathological retreat from interpersonal contact and social involvement, as may occur in schizophrenia, depression, or schizoid avoidant and schizotypal personality disorders. 2. (DSM III-R) A substance-specific organic brain syndrome that follows the cessation of use or reduction in intake of a psychoactive substance that had been regularly used to induce a state of intoxication. [EU] Xenograft: The cells of one species transplanted to another species. [NIH]

171

INDEX A Abdominal, 137, 160 Acceptor, 137, 159 Acetaminophen, 9, 31, 137 Acetone, 137, 154 Acetylcholine, 137, 158 Acidemia, 35, 37, 82, 137 Acidity, 137 Acidosis, 36, 137, 146, 154, 163 Acute renal, 11, 13, 137 Acyl, 8, 42, 137 Adenosine, 137, 138, 160 Adenovirus, 6, 56, 137 Aerobic, 137, 157, 160 Aerobic Metabolism, 137, 160 Aerobic Respiration, 137, 160 Aetiology, 12, 86, 137 Affinity, 137, 140, 166 Aflatoxins, 7, 138 Age Distribution, 82, 83, 138 Age Groups, 60, 138 Aged, 80 and Over, 138 Alkaline, 133, 137, 138, 141 Alternative medicine, 138 Amino acid, 88, 94, 138, 139, 140, 145, 150, 156, 159, 160, 162, 165, 167, 168 Amino Acid Sequence, 138, 139 Amiodarone, 79, 138 Ammonia, 23, 70, 72, 134, 138, 150, 151, 168 Analgesic, 52, 137, 138, 152 Anemia, 138, 156 Animal model, 27, 29, 81, 94, 95, 138 Antianginal, 138, 139 Antiarrhythmic, 138, 139 Antibodies, 8, 139, 161 Antibody, 43, 71, 138, 139, 144, 152 Antibody therapy, 43, 139 Anticoagulant, 139, 162, 169 Anticonvulsant, 139, 168 Antigen, 138, 139, 144, 151, 152, 157 Anti-infective, 139, 141 Anti-inflammatory, 137, 139, 140, 152, 165 Anti-Inflammatory Agents, 139, 140 Antipruritic, 139, 141 Antipyretic, 137, 139 Anus, 139, 163 Apolipoproteins, 139, 155

Appendicitis, 63, 139 Apraxia, 121, 139 Arginine, 81, 139, 158, 159, 168 Arterial, 139, 143, 152, 162, 167 Arteries, 139, 141, 145, 155, 157, 158 Arteriosclerosis, 139, 164 Aspartate, 86, 140 Assay, 31, 140 Astrocytes, 140, 157 Asymptomatic, 140, 160 Atrial, 138, 140, 169 Atrial Fibrillation, 140, 169 Atypical, 63, 140, 153 Auditory, 17, 140, 148 Autodigestion, 140, 160 Autoimmune Hepatitis, 31, 140 Autopsy, 13, 60, 69, 89, 140 Avian, 85, 140 B Bacteria, 137, 139, 140, 147, 148, 157, 158, 168 Base, 140, 146, 154, 168 Bile, 140, 149, 155, 162 Bile duct, 140, 149, 162 Biliary, 140, 160 Biliary Tract, 140, 160 Bilirubin, 133, 140, 149 Biochemical, 17, 23, 31, 77, 81, 98, 140, 162, 165 Biological response modifier, 140, 153 Biopsy, 35, 44, 51, 74, 78, 133, 134, 141 Biopsy specimen, 35, 141 Biotin, 141, 163 Bladder, 141, 168 Blood Coagulation, 141 Blood pressure, 141, 142, 152, 166 Blood vessel, 141, 142, 143, 147, 148, 154, 155, 161, 166, 167, 169 Body Fluids, 141, 147, 166 Bone Marrow, 121, 141, 149, 155, 157 Brachial, 141, 163 Brachial Artery, 141, 163 Bradykinin, 141, 158 Branch, 129, 141, 155, 160, 163, 166 Breakdown, 141, 146, 149, 159 C Calcium, 33, 141, 143, 144 Camphor, 19, 97, 141

172 Reye’s Syndrome

Carbamyl Phosphate, 9, 46, 88, 141 Carbohydrate, 142, 150 Carbon Dioxide, 142, 149, 152, 154, 163, 164 Cardiovascular, 15, 142, 164, 165 Cardiovascular disease, 142, 164 Carnitine, 18, 81, 83, 94, 98, 99, 142 Carotene, 142, 164 Case report, 51, 54, 58, 59, 60, 61, 63, 71, 78, 87, 142 Catecholamines, 142, 147, 157 Catheterization, 44, 142, 154 Causal, 28, 142, 165 Cause of Death, 26, 142 Cell membrane, 142, 154, 160, 166 Cell Respiration, 137, 142, 157, 160, 164 Central Nervous System, 137, 142, 148, 150, 157, 159, 165 Cerebellar, 54, 142 Cerebellum, 142, 149 Cerebral, 18, 20, 28, 90, 95, 142, 143, 145, 146, 149, 156, 163 Cerebrospinal, 19, 142, 143 Cerebrospinal fluid, 19, 142, 143 Cerebrum, 142, 143 Chickenpox, 118, 143 Chin, 143, 156 Cholesterol, 140, 143, 149, 155 Cholesterol Esters, 143, 155 Choroid, 84, 95, 143, 164 Choroid Plexus, 84, 95, 143 Chromatin, 143, 156 Chronic, 19, 97, 143, 152, 154, 160, 162, 163, 166, 168 Chylomicrons, 143, 155 Circulatory system, 143, 153 Cirrhosis, 118, 143, 151, 162 CIS, 143, 164 Citric Acid, 143, 154 Clinical trial, 113, 143, 162 Coagulation, 84, 141, 143, 169 Coenzyme, 40, 94, 144 Cofactor, 144, 162 Collagen, 138, 144, 149, 161 Collapse, 141, 144, 151 Comatose, 41, 144 Complement, 144 Complementary and alternative medicine, 97, 101, 144 Complementary medicine, 97, 144 Computational Biology, 113, 144 Cones, 145, 164

Conjugated, 145, 146 Conjunctiva, 145, 153 Connective Tissue, 141, 144, 145, 149, 164 Consciousness, 26, 132, 138, 145, 146, 151 Constriction, 145, 154, 163 Consumption, 16, 145, 160 Contamination, 145, 151 Contraindications, ii, 145 Convulsions, 86, 139, 145, 152 Coronary, 142, 145, 157, 158 Coronary Thrombosis, 145, 157, 158 Cortex, 139, 145, 148 Cortical, 64, 145, 165 Cranial, 142, 145, 150, 153, 159 Creatine, 21, 81, 145 Creatine Kinase, 81, 145 Creatinine, 145, 168 Critical Care, 7, 30, 33, 40, 41, 47, 58, 71, 74, 82, 92, 145 Cyclic, 21, 146, 150, 158, 160, 161 Cytochrome, 28, 146 Cytoplasm, 142, 146, 150, 156, 157 D Deamination, 146, 157, 168 Degenerative, 146, 151 Delirium, 87, 146, 151 Dendritic, 146, 166 Dengue Virus, 16, 146 Density, 146, 155 Diabetes Mellitus, 146, 164 Diabetic Ketoacidosis, 48, 146 Diagnostic procedure, 146 Dialyzer, 146, 151 Diastolic, 146, 152 Digestion, 140, 146, 155, 166 Direct, iii, 147, 163, 167 Discrete, 147, 162 Disorientation, 146, 147 Dopamine, 147, 157, 158 Duct, 142, 147, 148 E Edema, 86, 95, 132, 147, 153, 159, 168 Electrocoagulation, 143, 147 Electroencephalography, 20, 49, 147 Electrolyte, 146, 147, 166, 168 Electrophoresis, 147, 162 Elementary Particles, 147, 156, 162 Emboli, 147, 169 Embolism, 147, 163, 169 Embolization, 147, 169 Emollient, 147, 150 Encephalitis, 48, 70, 147

Index 173

Encephalitis, Viral, 147 Encephalopathy, 10, 22, 24, 25, 29, 37, 43, 49, 52, 70, 72, 75, 82, 83, 131, 148 Endemic, 148, 156 Endothelium, 148, 158 Endothelium-derived, 148, 158 Endotoxic, 148, 155 Endotoxin, 8, 29, 47, 148 Enteropeptidase, 148, 168 Environmental Health, 12, 112, 114, 148 Enzymatic, 25, 138, 141, 142, 144, 148, 164 Epidemic, 33, 34, 148 Epidemiological, 79, 148 Epigastric, 148, 160 Epithelial, 95, 148, 151 Epithelial Cells, 95, 148, 151 Erythrocytes, 138, 141, 148 Evoked Potentials, 17, 91, 148 Exhaustion, 148, 156 Exocrine, 90, 148, 160 Expiration, 148, 164 Extracellular, 140, 145, 148, 149, 166 Extracellular Matrix, 145, 148, 149 Eye Infections, 137, 148 Eye Movements, 121, 149 F Family Planning, 113, 149 Fat, 141, 142, 147, 149, 154, 155, 161, 164, 166, 168 Fatty acids, 27, 37, 42, 48, 55, 82, 146, 149 Fatty Liver, 25, 34, 52, 64, 89, 95, 121, 149 Febrile, 86, 146, 149, 156 Ferrets, 81, 149 Fetus, 149, 162 Fibroblasts, 85, 95, 149 Fibrosis, 149 Forearm, 44, 141, 149, 163 Fourth Ventricle, 143, 149 G Gallbladder, 137, 140, 149 Gallstones, 121, 149 Gas, 138, 142, 149, 151, 158, 163, 164 Gas exchange, 149, 164 Gastric, 140, 142, 149 Gene, 104, 137, 149, 155 Gene Therapy, 137, 149 Gland, 118, 149, 160, 166 Glomerular, 150, 163 Glucose, 94, 146, 150, 152, 153 Glutamate, 28, 41, 81, 150 Glutamate Dehydrogenase, 41, 81, 150 Glutamic Acid, 150, 158

Glutamine, 19, 31, 100, 150 Glycerol, 91, 150, 160 Glycine, 138, 150, 158, 165 Governing Board, 150, 162 Grade, 28, 150 Grading, 43, 150 Graft, 26, 150 Granulocytes, 150, 169 Growth, 141, 150, 153, 156, 157, 158, 161, 168 Guanylate Cyclase, 150, 158 H Headache, 150, 152, 153 Heart failure, 150, 159 Heat Stroke, 97, 151 Heme, 140, 146, 151, 161 Hemochromatosis, 121, 151 Hemodialysis, 63, 146, 151 Hepatic, 6, 8, 12, 20, 22, 23, 27, 28, 29, 43, 47, 85, 88, 91, 94, 95, 131, 134, 146, 151, 157, 161 Hepatic Encephalopathy, 8, 95, 151 Hepatitis, 20, 45, 91, 118, 120, 121, 151, 153 Hepatitis A, 45, 91, 118, 120, 151 Hepatocellular, 10, 151 Hepatocytes, 151 Hepatotoxicity, 31, 54, 151 Hepatovirus, 151 Heredity, 149, 151 Hormone, 151, 153, 164 Hydrogen, 137, 140, 142, 151, 157, 159, 162 Hydrolysis, 151, 155, 168 Hydrophobic, 151, 154, 155 Hydroxyproline, 138, 144, 151 Hyperammonemia, 30, 83, 87, 90, 95, 151 Hypersensitivity, 151, 164 Hypertension, 33, 142, 152, 153, 164, 168 Hyperventilation, 95, 152 Hypoglycaemia, 146, 152 Hypoglycemia, 56, 152 Hypotension, 33, 145, 152 Hypotonic Solutions, 152, 157 Hypoxia, 146, 152 I Ibuprofen, 46, 95, 152 Id, 96, 99, 120, 128, 130, 152 Idiopathic, 31, 152 Immune response, 139, 152, 169 Immune system, 139, 140, 152, 168, 169 Immunogenic, 152, 155 Impairment, 146, 149, 152 In vitro, 76, 77, 149, 152

174 Reye’s Syndrome

In vivo, 31, 149, 152 Indicative, 103, 152, 160, 169 Infancy, 60, 152 Infant Mortality, 121, 152 Infant, Newborn, 138, 152 Infarction, 152 Infection, 6, 16, 28, 39, 56, 57, 62, 72, 85, 95, 122, 140, 141, 146, 147, 148, 152, 153, 155, 164, 165, 166, 169 Infectious Mononucleosis, 153, 157 Infiltration, 70, 91, 153 Inflammation, 139, 140, 147, 148, 149, 151, 153, 158, 160, 161, 163, 164, 166, 169 Influenza, 7, 13, 22, 24, 28, 32, 34, 35, 37, 39, 40, 47, 54, 56, 62, 72, 81, 85, 94, 95, 100, 122, 153 Infusion, 153, 167 Ingestion, 19, 97, 153, 161 Inhalation, 153, 161 Insulin, 50, 146, 153, 154 Insulin-dependent diabetes mellitus, 153 Interferon, 34, 94, 153 Interferon-alpha, 153 Intermittent, 153, 160 Interstitial, 152, 153, 163 Intoxication, 7, 18, 28, 72, 94, 98, 146, 153, 169 Intracellular, 152, 153, 158 Intracranial Hypertension, 39, 47, 150, 153, 167 Intracranial Pressure, 20, 40, 49, 153, 163 Intravascular, 13, 153 Intravenous, 33, 39, 41, 134, 153 Intubation, 142, 154 Ischemia, 14, 154 Isocitrate Dehydrogenase, 81, 154 Isoenzyme, 86, 145, 154 Isoprenoid, 85, 154 Isotonic, 154, 157 J Joint, 62, 154 K Kb, 112, 154 Ketoacidosis, 55, 86, 137, 154 Ketone Bodies, 137, 146, 154 Ketosis, 146, 154 Kidney Disease, 34, 112, 154 Kidney stone, 154, 168 Kinetics, 38, 91, 154 L Lactulose, 87, 154 Large Intestine, 154, 163, 165

Larva, 155, 156 Laryngeal, 91, 155 Larynx, 155 Laxative, 154, 155 Leukocytes, 141, 150, 153, 155, 157 Library Services, 128, 155 Ligase, 155, 163 Lipid, 26, 29, 40, 50, 83, 94, 139, 150, 153, 155, 168 Lipid A, 26, 94, 155 Lipolysis, 8, 18, 155 Lipopolysaccharides, 155 Lipoprotein, 40, 155 Liver cancer, 121, 155 Liver Mitochondria, 23, 24, 155 Liver Transplantation, 118, 121, 155 Localized, 152, 155, 157, 159, 161, 168 Low-density lipoprotein, 155 Lymphatic, 148, 153, 155, 159, 166 Lymphatic system, 155, 166 Lymphocytes, 89, 139, 153, 155, 156, 166, 169 Lymphoid, 139, 156 Lysine, 37, 156, 168 M Magnetic Resonance Imaging, 156 Magnetic Resonance Spectroscopy, 31, 156 Malaria, 80, 156 Malaria, Falciparum, 156 Malaria, Vivax, 156 Malignant, 155, 156, 158 Medical Records, 156, 164 MEDLINE, 113, 156 Membrane, 140, 142, 143, 144, 145, 146, 148, 155, 156, 158, 159, 160, 164, 166, 167 Memory, 40, 146, 156 Mental, v, 112, 114, 131, 132, 143, 146, 147, 156, 163, 168 Mental Health, v, 112, 114, 156, 163 Metabolic disorder, 34, 42, 121, 151, 156 Metamorphosis, 75, 156, 159 MI, 10, 79, 94, 135, 156 Microbe, 157, 167 Microbiology, 140, 157 Microglia, 140, 157 Micro-organism, 157, 161, 165 Mitochondria, 23, 42, 83, 154, 157 Mitochondrial Swelling, 75, 157 Modification, 138, 157, 163 Molecular, 43, 85, 113, 115, 145, 157, 162

Index 175

Molecule, 139, 140, 144, 148, 151, 154, 157, 159, 163 Monoamine, 47, 79, 157, 168 Monoamine Oxidase, 47, 79, 157, 168 Monocytes, 155, 157 Mononuclear, 153, 157 Mononucleosis, 32, 100, 157 Morphology, 76, 157 Motor Activity, 145, 157 Myalgia, 153, 158 Mycotoxins, 138, 158 Myocardial infarction, 145, 156, 158, 169 Myocarditis, 56, 158 Myocardium, 156, 158 Myopathy, 39, 158 N Nasal Mucosa, 153, 158 Nausea, 132, 154, 158, 163, 165, 168 Need, 39, 41, 104, 123, 137, 158 Neonatal, 152, 158 Neoplasm, 158, 168 Nephropathy, 154, 158 Nerve, 91, 143, 157, 158, 159, 163, 164, 166, 167, 169 Nervous System, 142, 158, 168 Neural, 157, 158, 166 Neurologic, 121, 158 Neurotransmitter, 137, 138, 141, 147, 150, 158, 168 Nitric Oxide, 80, 158 Nitrogen, 88, 90, 150, 158 Nuclei, 149, 156, 158, 159, 162 Nucleic acid, 158, 159 Nucleus, 143, 146, 147, 156, 157, 159, 162 Nymph, 156, 159 O Ocular, 121, 159 Oedema, 13, 159 Ophthalmic, 159, 164 Opsin, 159, 164 Optic Nerve, 159, 163, 164, 165 Organ Transplantation, 54, 159 Ornithine, 7, 9, 23, 30, 36, 37, 38, 39, 45, 57, 81, 82, 88, 159 Osmolality, 43, 159 Osmoles, 159 Osmotic, 152, 157, 159, 165 Oxidation, 23, 28, 85, 94, 95, 137, 146, 159 Oxidative metabolism, 31, 94, 137, 159 Oxygen Consumption, 160, 164 P Pancreas, 90, 137, 141, 151, 153, 160, 168

Pancreatic, 9, 142, 160 Pancreatitis, 11, 13, 45, 46, 48, 54, 160 Paralysis, 91, 132, 139, 160 Pathogenesis, 45, 46, 48, 79, 85, 94, 160 Pathologic, 22, 42, 137, 141, 145, 151, 160 Pathophysiology, 83, 95, 160 Peptide, 138, 148, 160, 162 Peritoneal, 64, 78, 159, 160 Peritoneal Cavity, 159, 160 Peritoneal Dialysis, 64, 78, 160 Peritoneum, 160 Pharmacologic, 160, 167 Pharynx, 153, 160 Phosphodiesterase, 21, 160 Phospholipids, 149, 155, 160 Phosphorus, 141, 160, 161 Phosphorylated, 144, 161 Phosphorylation, 8, 161 Photocoagulation, 144, 161 Pigments, 142, 161, 164 Plague, 81, 98, 161 Plants, 142, 150, 157, 161, 163, 167 Plasma, 75, 76, 94, 139, 142, 143, 152, 161, 165 Plasma cells, 139, 161 Platelet Aggregation, 158, 161 Platelets, 158, 161, 165 Pleural, 159, 161 Pleural cavity, 159, 161 Pneumonia, 98, 145, 161 Poisoning, 41, 78, 98, 146, 153, 155, 158, 161 Polyunsaturated fat, 9, 24, 94, 161 Pontine, 45, 161 Porphyria, 121, 161 Porphyrins, 161 Posterior, 142, 143, 160, 162, 165 Postnatal, 23, 162 Practice Guidelines, 114, 162 Prealbumin, 51, 162 Prenatal, 23, 162 Presumptive, 69, 162 Primary Biliary Cirrhosis, 121, 162 Progression, 28, 74, 138, 162 Progressive, 143, 150, 162, 163, 168 Prophylaxis, 162, 169 Proportional, 159, 162 Protein C, 138, 139, 155, 162, 168 Protein Folding, 162 Protein S, 104, 162 Proteins, 138, 139, 141, 142, 143, 144, 145, 157, 158, 160, 161, 162, 165, 167

176 Reye’s Syndrome

Protocol, 22, 162 Protons, 151, 156, 162 Protozoan, 156, 162 Pseudotumor Cerebri, 153, 163 Psychic, 156, 163, 165 Psychomotor, 146, 163 Public Health, 8, 19, 25, 34, 49, 64, 84, 85, 104, 114, 163 Public Policy, 113, 163 Pulmonary, 49, 141, 145, 152, 163, 169 Pulmonary Embolism, 163, 169 Pulmonary Ventilation, 152, 163 Pupa, 156, 163 Pyogenic, 163, 165 Pyridoxal, 9, 163 Pyruvate Carboxylase, 22, 163 Q Quality of Life, 163, 166 Quaternary, 162, 163 R Radial Artery, 44, 163 Radius, 163 Receptor, 139, 147, 148, 163, 165 Rectal, 35, 163 Rectum, 139, 149, 154, 163 Refer, 1, 138, 144, 157, 163 Reflex, 149, 163 Refractory, 33, 147, 163 Renal failure, 146, 163, 168 Respiration, 77, 142, 164 Respiratory distress syndrome, 85, 164 Respiratory failure, 64, 164 Respiratory syncytial virus, 57, 164 Retina, 143, 145, 159, 164 Retinal, 18, 159, 164 Retinal Vein, 18, 164 Retinal Vein Occlusion, 18, 164 Retinol, 51, 164 Retrospective, 59, 164 Retrospective study, 59, 164 Rheumatism, 152, 164 Rheumatoid, 52, 54, 164 Rheumatoid arthritis, 52, 54, 164 Rhodopsin, 159, 164 Rigidity, 153, 161, 164 Risk factor, 16, 164 S Salicylate, 7, 10, 18, 20, 28, 31, 41, 55, 57, 71, 75, 79, 80, 82, 83, 94, 119, 165 Salicylic, 94, 165 Salicylism, 91, 165 Sclera, 143, 145, 165

Screening, 119, 143, 165 Seizures, 8, 79, 132, 146, 165 Septicaemia, 60, 165 Sequela, 17, 165 Serine, 165, 168 Serotonin, 157, 158, 165 Serotypes, 146, 165 Serum, 9, 20, 21, 23, 24, 28, 30, 31, 41, 42, 43, 47, 76, 77, 81, 82, 86, 134, 144, 145, 154, 155, 162, 165 Serum Albumin, 162, 165 Side effect, 165, 166, 167 Skeletal, 145, 165 Skeleton, 154, 165 Skull, 153, 165 Small intestine, 143, 151, 165, 168 Sodium, 88, 121, 165, 166, 168 Sodium Channels, 166, 168 Soft tissue, 141, 165, 166 Solvent, 137, 150, 159, 166 Soybean Oil, 161, 166 Specialist, 122, 166 Species, 100, 146, 156, 159, 166, 167, 169 Spike, 98, 166 Spleen, 121, 155, 166 Steatosis, 149, 166 Steroids, 94, 166 Stimulus, 148, 163, 166, 167 Stomach, 137, 140, 149, 151, 154, 158, 160, 165, 166 Stress, 133, 158, 164, 166 Subacute, 152, 166 Subclinical, 152, 165, 166 Subcutaneous, 147, 159, 166 Subspecies, 166 Supplementation, 99, 166 Support group, 120, 122, 135, 166 Supportive care, 11, 77, 166 Symptomatic, 160, 167 Synapses, 166, 167 Systemic, 83, 98, 141, 146, 153, 159, 167, 169 Systolic, 152, 167 T Threshold, 152, 167 Thrombosis, 162, 167 Tidal Volume, 152, 167 Tinnitus, 163, 165, 167 Tomography, 20, 156, 167 Toxic, v, 95, 138, 165, 167 Toxicity, 10, 62, 167 Toxicology, 15, 34, 114, 167

Index 177

Toxins, 135, 139, 147, 152, 158, 167 Transfusion, 20, 26, 167 Translation, 138, 167 Transplantation, 26, 51, 88, 167 Trauma, 146, 150, 160, 167, 168 Triglyceride, 86, 168 Trypsin, 148, 168 Tumour, 8, 16, 34, 168 Tyramine, 157, 168 U Ulcer, 47, 168 Unconscious, 152, 168 Uraemia, 160, 168 Urea, 40, 48, 90, 159, 168 Uremia, 163, 168 Urethra, 168 Uric, 82, 168 Urinary, 18, 90, 94, 95, 168 Urine, 6, 141, 145, 154, 168 V Vaccine, 162, 168 Valproic Acid, 13, 168 Valves, 15, 168 Varicella, 26, 28, 44, 85, 91, 169 Vascular, 138, 143, 148, 152, 153, 158, 159, 169

Vascular Resistance, 138, 169 Vasculitis, 160, 169 Vasodilatation, 20, 169 Vasodilators, 158, 169 Vein, 153, 164, 169 Venous, 159, 162, 169 Venous Thrombosis, 169 Ventricular, 138, 169 Veterinary Medicine, 113, 169 Villous, 143, 169 Viral, 16, 31, 39, 55, 71, 74, 86, 87, 91, 118, 122, 147, 153, 169 Virulence, 167, 169 Virus, 24, 28, 32, 34, 35, 39, 56, 62, 75, 94, 99, 143, 153, 164, 169 Viscera, 10, 24, 25, 43, 52, 70, 169 Vitro, 169 Vivo, 11, 169 W Warfarin, 62, 169 White blood cell, 121, 139, 153, 155, 156, 161, 169 Withdrawal, 146, 169 X Xenograft, 139, 169

178 Reye’s Syndrome