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Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Contents Contributors Preface
ix xiii
1
Production of Radionuclides in Accelerators David J. Schlyer
1
2
Accelerators Available for Isotope Production Thomas J. Ruth
71
3
Reactor Production of Radionuclides Leonard F. Mausner and Saed Mirzadeh
87
4
Chemistry of Nitrogen-13 and Oxygen-15 John C. Clark and Franklin I. Aigbirhio
119
5
Aspects on the Synthesis of 11C-LabelIed Compounds Gunnar Antoni, Tor Kihlberg and Bengt Långstrom
141
6
Chemistry of Fluorine-18 Radiopharmaceuticals Scott E. Snyder and Michael R. Kilbourn
195
1
Production and Application of Synthetic Precursors Labeled with Carbon-11 and Fluorine-18 Richard A. Ferrieri
. , 229
8
Automation for the Synthesis and Application of PET Radiopharmaceuticals David L. Alexoff
283
9
Design and Synthesis of 2-Deoxy-2-[18F]Fluoro-D-Glucose (18FDG) Joanna S. Fowler and Tatsuo Ido
307
vi 10 Technetium Radiopharmaceuticals Ashfaq Mahmood and Alun G. Jones
323
11
Chemistry of Gallium and Indium Radiopharmaceuticals Ronald E. Weiner and Mathew L. Thakur
363
12
Chemistry of Copper Radionuclides and Radiopharmaceutical Products Carolyn J. Anderson, Mark A. Green and Yasuhisa Fujibayashi
401
13 Chemistry Applied to Iodine Radionuclides Ronald Finn
423
14 Radiobromine for Imaging and Therapy Douglas J. Rowland, Timothy J. McCarthy and Michael J. Welch
441
15
467
Development of Radiolabeled Probes to Monitor Gene Therapy Chyng- Yann Shiue and Stephen L. Eck
16 Mechanism of Target Specific Uptake Using Examples of Muscarinic Receptor Binding Radiotracers William C. Eckelman
487
17 Strategies for Quantifying PET Imaging Data from Tracer Studies of Brain Receptors and Enzymes Jean Logan
501
18
Radiopharmaceuticals for Studying the Heart Dah-Ren Hwang and Steven R. Bergmann
529
19
PET Imaging Studies in Drug Abuse Research Joanna S. Fowler, Nora D. Volkow, Yu-Shin Ding, Jean Logan and Gene-Jack Wang
557
20
Research and Clinical Application of Neuroreceptor Imaging Henry N. Wagner, Jr. and Zsolt Szabo
581
21
Dynamic Neurotransmitter Interactions Measured with PET Wynne K. Schiffer and Stephen L. Dewey
603
22 Tumor Imaging Roland Hustinx and Abass Alavi
629
23
643
Radiolabeled Peptides for Tumor Imaging Linda C. Knight
CONTENTS
vii
24
Radiolabeled Antibodies for Tumor Imaging and Therapy Michael R. Zalutsky and Jason S. Lewis
685
25
Receptor Imaging of Tumors (Non-Peptide) John A. Katzenellenbogen
715
26
Pulmonary Function Imaging with PET Radiopharmaceuticals P. H. Elsinga and W. Vaalburg
751
27
Considerations in the Selection of Radionuclides for Cancer Therapy Amin I. Kassis and S. James Adelstein
767
28
Radiopharmaceuticals for the Study of Liver and Renal Function David R. Vera, Carl K. Hoh, Robert C. Stadalnik and Kenneth A. Krohn
795
Index
823
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch and Carol S. Redvanly Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3
