International Complete Collection of R&D Information About Traditional Chinese Materia Medica and Biotechnology Enterprises

INTERNATIONAL COMPLETE COLLECTION OF R&D INFORMATION ABOUT TRADITIONAL CHINESE MATERIA MEDICA AND BIOTECHNOLOGY ENTERPRISES ettifftr

Zhati Zhciigsong

Chemical Industry Press

World Scientific

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INTERNATIONAL COMPLETE COLLECTION OF R&D INFORMATION ABOUT TRADITIONAL CHINESE MATERIA MEDICA AND BIOTECHNOLOGY ENTERPRISES

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INTERNATIONAL COMPLETE COLLECTION OF R&D INFORMATION ABOUT TRADITIONAL CHINESE MATERIA MEDICA AND BIOTECHNOLOGY ENTERPRISES

editor-in-chief

Zhan Zhengsong

Academy of Military Medical Sciences, China

World Scientific NEW JERSEY

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SINGAPORE

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TA I P E I

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Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE and Chemical Industry Press No. 13 Qingnianhu South Street Dongcheng District Beijing 100011 P. R. China

British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library.

This edition is jointly published by World Scientific Publishing Co. Pte. Ltd. and Chemical Industry Press, P. R. China.

INTERNATIONAL COMPLETE COLLECTION OF R&D INFORMATION ABOUT TRADITIONAL CHINESE MATERIA MEDICA AND BIOTECHNOLOGY ENTERPRISES Copyright © 2011 by World Scientific Publishing Co. Pte. Ltd. and Chemical Industry Press All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the Publisher.

For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher.

ISBN-13 978-981-4291-56-9 Typeset by Stallion Press Email: [email protected]

Printed in Singapore.

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CONTENTS

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii About the Editor-in-Chief . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix List of Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

x

List of Abbreviations of Technological Expertise . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xii List of Enterprises 1

N . . . . . . . . . . . . . . . . . . . . . . 603

B . . . . . . . . . . . . . . . . . . . . . . 88

O . . . . . . . . . . . . . . . . . . . . . . 639

C . . . . . . . . . . . . . . . . . . . . . . 183

P . . . . . . . . . . . . . . . . . . . . . . . 664

D . . . . . . . . . . . . . . . . . . . . . . 274

Q . . . . . . . . . . . . . . . . . . . . . . 738

E . . . . . . . . . . . . . . . . . . . . . . 306

R . . . . . . . . . . . . . . . . . . . . . . 746

F . . . . . . . . . . . . . . . . . . . . . . . 340

S . . . . . . . . . . . . . . . . . . . . . . . 772

G . . . . . . . . . . . . . . . . . . . . . . 354

T . . . . . . . . . . . . . . . . . . . . . . 842

H . . . . . . . . . . . . . . . . . . . . . . 401

U . . . . . . . . . . . . . . . . . . . . . . 878

I . . . . . . . . . . . . . . . . . . . . . . . 425

V . . . . . . . . . . . . . . . . . . . . . . 886

J . . . . . . . . . . . . . . . . . . . . . . . 485

W . . . . . . . . . . . . . . . . . . . . . . 907

K . . . . . . . . . . . . . . . . . . . . . . 494

X . . . . . . . . . . . . . . . . . . . . . . 917

L . . . . . . . . . . . . . . . . . . . . . . 511

Y . . . . . . . . . . . . . . . . . . . . . . 921

M . . . . . . . . . . . . . . . . . . . . . . 537

Z . . . . . . . . . . . . . . . . . . . . . . 923

A ......................

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 931 Keywords Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 933

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PREFACE

Since the 1980s, biotechnology companies worldwide, especially the medical biotechnology companies, have made new discoveries, ventured into research and development (R&D) projects and brought about a new wave of approved medicines that come roughly to over 200,000 types. Traditional Chinese materia medica (TCMM) is a great wonder of medical science created by the Chinese people thousands of years ago. Our socio-economic conditions as well as technological and scientific advancement, have brought tremendous changes to our living environment and standard of living, which result in an evolving change to the disease pattern of human as well as the medical and treatment modes. On the other hand, there is an increasing awareness of the importance of TCMM towards the enhancement and improvement of human health. This directory — International Complete Collection of R&D Information about TCMM and Biotechnology Enterprises — is primarily adapted from the Chinese edition of the Information Handbook of Medicinal and Biotechnology Enterprises as a chief source with new addition of information on TCMM companies. It is a compilation of upto-date essential information — such as R&D expertise, technological capabilities, principal products/instrumentation — of about 3,000 companies from 50 countries and regions spanning across Asia, Africa, America, Europe and

Oceania. The directory also includes a brief review of the latest product and research development of the companies. Put together by more than 80 editors who researched and sourced the information from a wide range of reliable resources such as books, journals, and website references, the directory took 20 painstaking months to complete. I hope this book serves as a stimulating guide to researchers in this area and to a broader scientific community with a general interest in the field of TCMM and Biotechnology. I would like to express my heartfelt appreciation to all editors for their enthusiasm and support of this compendium of useful information. I am also indebted to World Scientific Publishing Co Pte Ltd and Chemical Industry Press of China for the opportunity to publish this directory. Last but not least, I am very thankful to my wife Yu Zhijia for her patience and understanding during the editing process. This directory was compiled within a short timeframe; hence, any errors or omissions are unintentional and we apologize for any errata. We welcome your comments and feedback, and also appreciate your calling to our attention any errors in the resource. Zhan Zhengsong [email protected] April 2010

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ABOUT THE EDITOR-IN-CHIEF

was a consultant on the AMMS Advisory Committee for New Drugs Research, Deputy Director of AMMS Laboratory Animals Governing Board, and consultant of the Military Professional Titles Foreign Examination Center. He was a special contributor of military medicine for the world military yearbook. To date he has published more than 60 papers, translated 4 books, and co-edited 20 books. He was awarded the second prize by the Military Science and Technology Progress Review Committee based on achievements in four areas: nuclear, biological and chemical warfare defense of Chinese military and military medicine, countermeasure suggestion of military medicine biotechnology development, research paper for the development strategy of new military medicine, and the basic and clinical research of high-altitude pulmonary heart disease. He was also awarded a second prize by the National Science and Technology Committee for his book entitled Research, Progress, Prediction and Countermeasure of Information in Military Medicine Development Strategy.

Zhan Zhengsong ( ) is an emeritus professor and researcher at the Academy of Military Medical Sciences (AMMS), China. He studies military medicine using different languages, i.e. German, English, Japanese and Russian. His research focus includes nuclear, biological and chemical weapons, battle surgery, sanitation, environmental medicine and military biotechnology. He also performs information investigation on the current situation and future development of medicinal sciences. Prof. Zhan is a senior translator of the Chinese Translators Society and a senior military translator of the Chinese Military Science Translators Committee. Before retirement, he

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LIST OF CONTRIBUTORS

EDITORS Zhan Zhengsong ( Xian Qiusheng ( Li Yi ( ) Rong Wenhui ( Wang Xiaoyu ( Jiang Haojing ( Li Yang ( )

) ) ) ) )

Li Yuequn ( ) Zhang Xiaoyan ( Li Yue ( ) Liu Lihua ( ) Wang Yongyan ( Li Jing ( ) Liu Ying ( )

)

)

Wei Yongtang ( ) Piao Chunyi ( ) Hu Yunhe ( ) Yan Zheng ( ) Jiang Tengfang ( ) Xue Junfeng ( ) Cao Ling ( )

TRANSLATORS/PROOFREADERS Zhan Zhengsong ( ) Lou Tiezhu ( ) Liu Hongfang ( ) Ma Liren ( ) Tian Renmao ( ) Zhao Gonglin ( )

Wang Ling ( ) Gao Yue ( ) Cynthia Chang ( ) Xu Qishou ( ) Wang Xianming ( ) Hu Yunlong ( )

Bao Guoqiang ( ) Jiang Mingmin ( ) Ling Ruiqin ( ) Liu Keling ( ) Miao Jihong ( )

Hao Junqin ( Sun Liangzhi ( Zhan Jing ( ) Zhan Xinda ( Ma Hongyue ( Tian Mingqing ( Wu Xiaoyan ( Yu Gui ( ) Jin Xianglan ( Deng Zhenhua ( Tang Qiuhong ( Ma Hui ( )

Wang Wenbo ( ) Zhang Xinkuan ( ) Yang Hui ( ) Chen Wei ( ) Zhang Mei ( ) Yu Hongbo ( ) Jiang Fang ( ) Zhang Jintao ( ) Xing Guangyu ( ) Lin Shanren ( ) Liu Xuezhen ( ) Hu Kai ( )

ASSISTANT EDITORS Tao Ran ( ) Zhang Feng ( ) Zhang Bingran ( ) Zhan Wencheng ( ) Feng Mei ( ) Lu Yaping ( ) Yu Zhipei ( ) Yang Yongli ( ) Yu Bo ( ) Lang Feng ( ) Zhang Lei ( ) Tian Shujun ( )

x

) ) ) ) ) ) ) ) )

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List of Contributors

Zhang Lili ( ) Niu Liangshun ( Liu Kun ( )

)

Zhang Ning ( ) Sun Shixiang ( Zhou Zhemin (

) )

Qian Daming ( Wang Haoran (

BOOK COVER DESIGN Ma Ling (

)

Yin Liang (

)

Azouri Bongso

xi

) )

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LIST OF ABBREVIATIONS OF TECHNOLOGICAL EXPERTISE AB AF AMS AS AU BA BC BI BME BP BS BTS CB CC CH/S CHT CMH CMM COC COS CPHC CS CSDP C/TC CW DD D-D DDI DK DKHC E ERT ET

antibody antifungals analytical mass spectrometry antisense automation bioprocess automation biocatalysis bioinformatics biomedical equipment bioprocess blood substitutes biotechnology software carbohydrate biotechnology chiral chemistry computer hardware/software Chinese herbal therapy Chinese medicinal herbs Chinese moxibustion medicine combinatorial chemistry custom organic synthesis contract purification HPLC and CCC chemical synthesis chemical synthesis of DNA and peptides cell/tissue culture contract work drug delivery drug design drug discovery DNA kit DNA kits & HPLC columns enzymology enzyme reactor technology enzymetic technique

F FE FL G GA GB GM GP GT HC H/CF HDT HNT HTDS LC/TC LP M MAE MP NAC OC O-C P PA PC PG PI PIS PLHDDT

PMC POS P/P xii

fermentation fermentation engineering fluorescence labeling genomics gene amplification gene bank growth media GMP production gene therapy HPLC columns hybridoma/cell fusion HLA DNA typing high new technology high throughput drug screening large-scale cell/tissue culture large-scale purification macrolide monoclonal antibody engineering marine pharmaceuticals nucleic acid chemistry organic chemistry organic catalysts peptide polyclonal antibodies protein chemistry pharmacogenomics peptide instrumentation peptide isolation and synthesis polymeric-, lipid- and HAbased drug delivery technology process monitoring control polymer science purification/production

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List of Abbreviations of Technological Expertise

PPAT P/PS PS P/S PS/AP Q R RD RDS RM RPP S

protein and peptide-based anticancer therapeutics protein/peptide sequencing peptide synthesis purification/separation peptide synthesis/antibody production quinolines robotics recombinant DNA recombinant DNA scale-up raw materials recombinant protein production sequencing

SAADP SC SI SMC SSMSA SY T TCMM TDI TE TTM

synthesis of amino acid derivatives and peptides surface coating synthesis instruments small molecule chemistry spot synthesis on membranes and screening assays synthesis transgenics traditional Chinese meteria medica TCM diagnostic instruments tissue engineering traditional Tibetan medicine

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LIST OF ENTERPRISES

R&D expertise: Research, development, production and marketing of specialty protein products.

1 AALTO SCIENTIFIC, LTD. Add: 1959 Kellogg Ave. Carlsbad, CA 92008

Technological expertise: RD, F, BA, Q, E, GA, P/S

Tel: (760) 431-7922 Fax: (760) 431-6942

Principal products/instrumentation: Specialty protein: Kappa lock Kappa™ light chain binding protein, dehydrogenase enzymes, SOD.

E-mail: [email protected] Web site: www.aaltoscientific.com President/CEO: Steve Mauro Research director: Bob Reynolds

3 AASTROM BIOSCIENCES, INC.

R&D expertise: Development and manufacturing of in vitro diagnostic controls & calibrators, purification of human enzymes & proteins, processing bulk human serum.

Add: 24 Frank Lloyd Wright Dr., P.O. Box 376, Ann Arbor, MI 48106 Tel: (734) 930-5777

Technological expertise: E, PA, P/S

Fax: (734) 665-0485

Principal products/instrumentation: In vitro diagnostic controls, including clinical chemistry, immunoassay, cardiac markers, and specialty controls.

E-mail: [email protected] Web site: www.aastrom.com President/CEO: R. Douglas Armstrong, Ph.D.

Main products/instrumentation under R&D: Monoclonal antibodies to carbonic anhydrase III (verifier to myoglobin), development stage; tumor marker panel control, research.

R&D expertise: Cell culture immunology research, development of systems for stem cell and blood therapy and gene therapy, DNA damage analysis. Technological expertise: TE, CH/S, GT, C/TC

2 AASTON, INC.

Main products/instrumentation under R&D: Aastrom Replied™ Cell Production System for stem cell therapy and other cell therapies; Aastrom™ Gene Loader for high efficiency gene transfer; Aastrom cell production system (stem and progenitor cell expansion from bone marrow and umbilical cord blood), blood and immune system recovery in cancer patients

Add: 12 Falmouth Rd. Weiiesley, MA 02481 Tel: (781) 237-3755 Fax: (781) 239-0455 E-mail: [email protected] President: Randolph T. Hatch, Ph.D. 1

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following chemotherapy ablation/suppression, Phase III completed, 2008; Phase II trial of Cardiac Repair Cells (CRCs), a mixture of stem and progenitor cells derived from a patient's own bone marrow, for the treatment of dilated Cardiomyopathy (DCM), a severe form of chronic heart failure, 2008. Sealed and granted patents: Stem cell replication and stem cell transduction; gene transfer enhancement; stem cell compositions of matter.

4 ABB BOMEM, INC. Add: 585 Charest Blvd. E., Ste. 300 Quebec G1K9H4 Canada Tel: (418) 877-2944 Fax: (418) 877-2834 E-mail: [email protected] Web site: www.bomem.com

R&D expertise: Peptide design and manufacturing, peptide instrumentation, bulk pharmaceuticals/chemicals development and custom manufacturing. Technological expertise: F, SY, CS, RD, OC, Q, M Principal products/instrumentation: Custom and standard products to meet specific needs, peptide library, peptide hormone, erythromycin, clindamycin, spectinomycin, vancomycin, butamben, disuifiram, hydrochlorothiazide, maprotiline hydrochloride, methyclothiazide, sodium nitroprusside, pramoxine hydrochloride, prazosin hydrochloride, TRH, cyclamates, peptides, monitor peptides. Main products/instrumentation under R&D: Amrinone, atracurium, butophanol, misoprostol; adalimumab (Humira), III, 2008; afelimomab (segard), IV, 2008; peptide sequencer, peptide synthesizer; Phase III psoriasis studies with ABT-874, 2007.

President: Garry Vail Research director: Raymone Roberge Subsidiary of ABB Group R&D expertise: Research, development and production of analytical instrumentation for drug research lab. Technological expertise: M Principal products/instrumentation: Prota — protein secondary structure analysis, 1997; ChiralIR — chiral molecule analyzer, drug analytical instruments.

5 ABBOTT LABORATORIES, CHEMICAL BUSINESS UNIT Add: 100 Abbott park Rd., Abbott park, IL 60064-3500 Tel: (800) 240-1043, (847) 937-6100 Fax: (847) 937-1511 President: Robert L. Parkinson, Jr., COO Research director: John Leonard

6 ABCAM, LTD. Add: Tennis Court Rd. Cambridge CB2 1QR UK Tel: 44 (0) 1223-766442 Fax: 44 (0) 1223-766480 E-mail: [email protected] Web site: www.abcam.com President/CEO: Dr. Jonathan Milner Research director: Dr. Jonathan Milner R&D expertise: Development of high quality antibodies and other pharmaceuticals. Joint ventures: Novus Biologicals (antibodies), Genetor (antibodies), Aves Labs (antibodies), Serotec (antibodies). R&D collaboration: Novus Biologicals (antibodies), Genetor (antibodies), Aves Labs (antibodies), Serotec (antibodies). Key sales market contracts: Novus Biologicals (antibodies), Genetor (antibodies), Aves Labs (antibodies), Serotec (antibodies).

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Key license and trade contracts: Imperial Cancer Research Technology ICRT. Technological expertise: P/S, H/CF, BI, AB Principal products/instrumentation: Cancer research antibodies, 1999; high sensitivity antibodies. Main products/instrumentation under R&D: Biopharmaceuticals.

7 ABCELL

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Principal products/instrumentation: Bioreactors used in the production of therapeutics, bioprocessing equipment, bioprocess engineering technology.

9 ABER INSTRUMENTS, LTD. Add: Science Park Aberystwyth, Dyfed SY23 3AH UK Tel: (44) 1970-636300 Fax: (44) 1970-615455

Add: P.O. Box 62, Fin-33101 Tampere FIN-33101 Finland Fax: (358) 3-265-6213 E-mail: [email protected] Web site: www.kolumbus.fi/abceil President/CEO: Terho Eloranta R&D expertise: Visualization research and development of macromolecules & immunodiagnostics. Key sales market contracts: Clare Chemical research (USA), Biomedica G.M.B.H. (Austria), Suomen Biotekniikka OY Cofactor (Finland) Technological expertise: PA, H/CF, C/TC, GM Principal products/instrumentation: Plasma Cell Growth Supporter™ AB-Max, 1996; macromolecule products, macro molecular ligand.

E-mail: [email protected] Web site: www.aber-instruments.co.uk President: Barry Wise Research director: Dr. Bob Todd R&D expertise: Development and manufacture of on-line and off-line instrumentation for monitoring and control of Biomass. Joint ventures: Distribution by Applikon Inc. in USA and Canada. Technological expertise: F, M, BA, C/TC, SI Principal products/instrumentation: 214M Biomass Monitor, 1992; 520 Viable Cell Monitor, 1996; Microcyte Flow Cytorneter; viable cell analyser 820, on-line data handling equipment. Main products/instrumentation under R&D: Viability measurement for yeast and animal cells, monitoring and control device of biomass.

8 ABEC Add: 6390 Hedgewood Dr. Ailentown, PA 18106 Tel: (610) 366-7800

10 ABGENE

Fax: (610) 395-8147

Add: Abgene House Blenheim Rd. Epsom, Surrey KT 19 9AP UK

CEO: Jack Wilson

Tel: (44) 0 1372-723456

Research director: Marvin Charles, Ph.D.

Fax: (44) 0 1372-741414

R&D expertise: Research, design and development of custom bioreactors and bioprocessing equipment; bioprocess engineering.

E-mail: [email protected]

Technological expertise: F, M, CH/S, P/S, BA, C/TC

President: Paul Day, Managing Director

Web site: www.abgene.com Research director: Ariel Louwrier

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R&D expertise: Development and production of reagents and consumables for molecular biology research; important innovation research in products for this market. Key license and trade contracts: HoffmannLa Roche license to supply TAQ DNA Polymerase. Technological expertise: PG, P/S, G, GA, COC Principal products/instrumentation: Products for: PGR, drug discovery, HTS, Genomics platform, proteomics platform, monitoring reagents. Subsidiary bodies: France, Germany, and USA.

11 ABGENIX, INC. Add: 7601 Dumbarton Circle Fremont, CA 94555 Tel: (510) 608-6500 Fax: (510) 608-6589 E-mail: [email protected] Web site: www.abgenix.com President/CEO: R. Scott Greer Research director: Dr. C. Geoffrey Davis R&D expertise: Develop biotech medicines proprietary transgenic mice technology, focused on the development and commercialization of monoclonal antibodies to treat a wide range of diseases. Key license and trade contracts: Pfizer Inc. — cancer; Schering-Plough Research Institute — inflammation; Genentech, Inc. — growth factor modulator and cardiovascular; Millennium Bio therapeutics, Inc. — inflammation; Cell Genesys, Inc. — gene therapy; U.S. Army — infectious diseases; Centocor — cardiovascular; Avi Biopharma — cancer; BASF Research Corporation; AMGEN; Japan Tobacco — psoriasis inflammation; Research Corporation Technologies — immune tolerance.

Technological expertise: F, Q, T, C/TC, GA, H/CF, P/S, RD Principal products/instrumentation: XenoMouse technology for creation of fully human monoclonal antibodies. Main products/instrumentation under R&D: ABX-IL8 for treatment of psoriasis, Phase II/ III; ABX-CLB, treat GVHD, Phase III completed; ABX-CBL, monoclonal antibody for graft versus host disease (GVHD), Phase II completed; ABX-ID3, psoriasis, other inflammatory diseases, Phase I/II completed, Phase I; ABX-EGF, various cancers, Phase I; ABXRB2, transplant rejection, autoimmune disorders, preclinical; panitumumab (ABX-EGF), for treatment of colorectal cancer, lung cancer and prostate cancer etc, Phase III, 2008. Sealed and granted patents: Methods for expressing and recovering human monoclonal antibodies to CTLA-4. 7,109,003, U.S.; Antibodies to insulin-like growth factor I receptor. 7,037,498, U.S.; Production of multimeric protein by cell fusion method. 6, 420, 140, U.S.; Antibodies against the MUC 18 antigen. 6,924,360, U.S.; Methods for using ant-MUCI 18 antibodies. 7,067,131, U.S.; Production of antibodies using cre-mediated site-specific recombination. 6,458,592, U.S.; Use of antibodies against the MUC 18 antigen. 7,090,844, U.S.; Lactoferrin in the treatment of diabetes mellitus patents pending. 7,034, 126, U.S.; Human monoclonal antibodies to CTLA-4. 6,682,736, U.S. (2002–2008); other patents pending.

12 ABIMED ANALYSEN-TECHNIK GMBH Add: Raiffeisenstrasse 3 Langenfeld 40764 Germany Tel: (49) 21 73-89050 Fax: (49) 21 73-890577 E-mail: [email protected]

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Web site: www.abimed.de

E-mail: [email protected]

President: Klaus Zinecker

Web site: www.academybiomed.com

Research director: Dr. Heinrich ausepohi

President/CEO: George C. Yang

R&D expertise: Development and manufacturing of peptide instrumentation, peptide automated liquid handling, peptide synthesis and, life sciences.

Research director: Charles Yang

Technological expertise: P/S, COC, PIS, CS Principal products/instrumentation: HPLC Automated Liquid Handling, Pipetting Systems, Environmental Pollutant Analysis, Peptide Mimetic Design Synthesis, Protein Digestion, In situ hybridization technology.

5

R&D expertise: Research and production of heart diseases related human lipoproteins, antigens and polyclonal antibodies. Technological expertise: PA, P/S, AB, BS Principal products/instrumentation: Goat anti-APOE antibody, 1995; Sheep anti-apo(e) antibody, 1996; Goat anti-MDA antibody, 1999; Goat anti-nitrotyrosine antibody, human lipoprotein-associated coagulation inhibitor (nLACI).

13 AB, SA.NGTEC MEDICAL Add: Ballstavagen 30 Box 20045 Bromma S-16120 Sweden

15 ACADIA PHARMACEUTICALS

Tel: (46) 8-635-1200

Add: 3911 Sorrento Valley Blvd. San Diego, CA 92121

Fax: (46) 8-829-2181

Tel: (858) 558-2871

Web site: www.sangtecmd.com

Fax: (858) 558-2872

President: Hans Henriksnas Research director: Jan Brundell R&D expertise: R&D immunodiagnostics and DNA analysis technologies, DNA damage analytical technologies. Technological expertise: C/TC, H/CF, GA, RD Principal products/instrumentation: Tumor markers for TPA, NSE, TK, FLAP, S-100 — Prolifigen™, DNA based immuno diagnostics for hepatitis R, Cystic Fibrosis, APOE, alpha1 Antitrypsin, Affigen™, AffiProbe™, DNA database, DNA detection kits, immuno detection reagent.

14 ACADEMY BIOMEDICAL CO. Add: 1417 Kress St. Houston, TX 77020 Tel: (281) 546-2613 Fax: (713) 673-4049

E-mail: [email protected] Web site: www.acadia-pharm.com President: Mark R. Brann, Ph.D. Research director: Mark R. Brann, Ph.D. R&D expertise: Drug discovery, research design, development and manufacture. R&D collaboration: Allergan, ArQuie. Key license and trade contracts: Allergan. Technological expertise: SMC, PG, HTDS, DDI, BA, BC, D-D Subsidiary bodies: Copenhagen (Glostrup), DK. Main products/instrumentation under R&D: Drug delivery devices, drug discovery route, drug proprietary discovery technology, ACP103, Phase II, 2007. Sealed and granted patents: Proprietary Discovery Technology.

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16 ACCELERATED TECHNOLOGY LABORATORIES, INC. Add: 496 Holly Grove School Rd. West End, NC 27376 Tel: (910) 673-8165 Fax: (910) 673-8166 E-mail: [email protected] Web site: www.atlab.com

1–3 microns with strepavidin, biotin, (dT)25mRNA hooks, antibodies and antigens on a custom basis only, metallo Affinity isolations; alternative to magnetic beads, tluidized bed technology, process affinity chromatography, cell separations devices, thin layer chromatography. Subsidiary bodies: Laboratory — 3150-8 Skokie Highway, Highland Park, IL 60035. Sealed and granted patents: U.S. Patent No. 5,245,024 and others pending.

President: Don Kolva R&D expertise: Laboratory Automation and LLVIS (Laboratory Information Management Systems) of novel drug R&D and products manufacturing. Technological expertise: CH/S, BI Principal products/instrumentation: Sample Master™ and the Enterprise Edition Sample Master Pro laboratory information management system. Main products/instrumentation under R&D: Laboratory research software, for many industries including medical and drug biotechnology enterprises.

17 ACCURATE POLYMERS, LTD. Add: 3150 Skokie Hwy. — Unit 7 Highland Park, IL 60035 Tel: (847) 266-0043

18 ACCUTEK LABORATORIES, INC. Add: 9212 Mira Este CX, Ste. 100 San Diego, CA 92126 Tel: (858) 536-3344 Fax: (858) 536-3342 E-mail: [email protected] Web site: www.accuteklab.com President: A. Spector R&D expertise: Research, design, development and manufacturing of calibration devices and instruments, pipettes and liquid handling, sale, service of pipettes. Technological expertise: CH/S Principal products/instrumentation: AccuPet™, AccuPet TPM™, pipet washer, pipet controller lab calibration devices/instruments for drug research.

Fax: (847) 266-9079 President/CEO: Dr. William D. Garner Research director: Dr. Ioannis Scarpa R&D expertise: Products for diagnostics and biopurification research, development and manufacturing. Joint ventures: North American Corp. Technological expertise: Q, SMC, RD, P/S, PIS, HTDS, DD, COC, C/TC Principal products/instrumentation: Orbkel™ 1992, bead-bed reactor, small beads of

19 ACLARA BIOSCIENCES Add: 1288 Peal Av. Mountainview, CA 94043 Tel: (650) 210-1200 Fax: (650) 210-1210 E-mail: [email protected] Web site: www.aclara.com President/CEO: Joseph M. Limber Research director: Scott Braxton

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R&D expertise: Research and development of microfluidic based systems.

Tel: (44) 0 1223-728453

R&D collaboration: Perkin Elmer, multinational pharmaceutical organizations; Hitachi Chemical.

E-mail: [email protected]

Key license and trade contracts: Lawrence Livermore National Labs.

CEO: Dr. Steven Powell

Technological expertise: BI, Q, R, P/S, HTDS, CH/S Main products/instrumentation under R&D: Microsequencer; high throughput screening system, microfluid management system. Sealed and granted patents: U.S. patents are pending.

20 ACORDA THERAPEUTICS, INC. Add: 15 Skyline Dr. Hawthorne, NY 10532 Tel: (914) 347-4300

7

Fax: (44) 01223-728448 Web site: www.actinova.co.uk Research director: Dr. Peter Laing R&D expertise: Research/development of biopharmaceuticals — protein engineering, microbiology, and immunology; products manufacturing. Technological expertise: PA, P/S, BI, BA, CH/S, D-D, G, HTDS, PIS Principal products/instrumentation: Protein L, 1997; protein, LA 1998 Main products/instrumentation under R&D: Anticaries peptide/P1025, Phase 1; Group A. Streptococcus Vaccine, Preclinical; Covalent Display Technology, Affinity Chromatography, protein determination, protein conducting channel.

Fax: (914) 347-4560 E-mail: [email protected]

22 ACTIPAC BIOSYSTEMS GMBH

Web site: www.acorda.com President/CEO: Ron Cohen, M.D. Research director: Andrew Blight, Ph.D. R&D expertise: Research of cell/tissue culture, spinal cord injury, MS and related neurological conductions.

Add: AM Klopferspitz 19 Martinsried/Munchen D-82152 Germany Tel: (49) 089-740 1540 Fax: (49)089-740 15410 E-mail: [email protected]

Joint ventures: Han Pharmaceuticals

Web site: www.actipac.de

Technological expertise: PA, TE, H/CF, GT, DD, C/TC

President: Enno Spillner

Main products/instrumentation under R&D: Remyelinating Antibody-preclinical; Spinal Cord Regeneration — R&D; nerve conduction enhancing drug — clinical, spinal cord injury therapeutic, R&D.

R&D expertise: Design and products manufacturing of drug delivery systems.

Sealed and granted patents: Methods for treating muscle diseases and disorders 7,037,888 U.S.

21 ACTINOVA, LTD. Add: 185 Cambridge Science Park Milton Road Cambridge CBA OGA UK

Research director: Dr. Celal Albayrak

Technological expertise: GT, DD Main products/instrumentation under R&D: Microencapsulated drugs, preclinical; drug screening technology. 23 ACTIVE PASS PHARMACEUTICALS, INC. Add: Room 5830, 2255 Wesbrook Mall Vancouver, BC V6T 1Z3 Canada

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Tel: (604) 822-7981

Tel: (44) 158-259-7676

Fax: (604) 822-7524

Fax: (44) 158-258-1495

E-mail: [email protected]

E-mail: [email protected]

Web site: www.activepass.com

Web site: www.adaptive.co.uk

President/CEO: Peter B. Reiner

CEO: T. J. Bonham Carter

R&D expertise: Research, development and manufacture of Alzheimer disease therapeutics and other biotech medicines.

Research director: Dr. C. Taylor

Technological expertise: BI, C/TC, CH/S, GA, G, PG, RD, PA, Q, SMC Principal products/instrumentation: Biologicals, pharmaceuticals, vaccines, Alzheimer disease therapeutics, reagents, enzymes.

24 A. DAIGGER Add: 675 Heathrow Dr. Lincolnshire, IL 60069-4200 Tel: (800) 621-7193

R&D expertise: Biotechnology software research, design, develop and manufacture software systems control. R&D collaboration: Brunel University, UK; University College, London, UK. Technological expertise: F, M, CH/S, BA, BTS Principal products/instrumentation: BioView control software, BIOVIEW; Tandem dual gas sensor, BioReactors, Mass flow controllers, biotechnology medicine software.

26 ADHEREX TECHNOLOGIES, INC.

Fax: (800) 320-7200 E-mail: [email protected] Web site: www.daigger.com President: James R. Waldenberg R&D expertise: Development of clinical packaging, labeling, drug storage, drug distribution, clinical trials software and laboratory research products. Technological expertise: COC, BC, COS, CS, FE, HTDS, P/S Principal products/instrumentation: Mixers, 1995; Label Maker; Microscope Slide Boxes; Calculators; Mini Micro Centrifuge; Pipette Tips; Weigh Dishes for Balances; Water Baths; Hearing Blocks, clinical packaging extract, drug clinical trial software.

25 ADAPTIVE BIOSYSTEMS, LTD. Add: P.O.Box 2203, 15 Ribocon Way Progress-Park Luton LU4 9FT UK

Add: 600 Peter Morand Cres. Ottawa, Ont. K1G 5Z3 Canada Tel: (613) 738-8000 Fax: (613) 738-9060 Web site: www.adherex.com President: John Brooks Research director: Orest Blaschuk, Ph.D. R&D expertise: The research and development of agents that treat several cancers by modulating cadherin mediated cell adhesion. Joint ventures: McGill University R&D collaboration: McGill University, University of Ottawa, University of Toronto, Georgetown University, Princeton University, Weizmann Institute (Israel). Technological expertise: PI, DD, D-D, PIS Main products/instrumentation under R&D: Cadherin modulators, pre-clinical; anticancer agents, R&D.

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Sealed and granted patents: Compounds and methods for cancer therapy. 6,797,807, U.S.; Compounds and methods for stimulating betacatenin mediated gene expression and differentiation. 6,706,685 U.S; Compounds and methods for modulating junctional adhesion molecule-mediated functions. 6,391,855 U.S. (2008); others pending.

27 ADINSTRUMENTS, INC. POWERLAB/MACLAB DIV. Add: 115 Cedar St. Suite N-4 Milford, MA 01757 Tel: (508) 478-6887 Fax: (508) 634-8869 E-mail: [email protected] Web site: www.adinstruments.com President/CEO: William P. Mitchell Research director: Ashish More R&D expertise: Research, develop, manufacture and sell computer based recording systems, transducers, electrodes and signal conductioners. Technological expertise: HC, CPHC, RPP Principal products/instrumentation: MacLab Recording Systems for Macintosh — 1991; PowerChrom Chromatography Data System — 1995; PowerLab Recording System for Windows based computers — 1996; electrode/ signal conductioners, tranducers.

9

R&D expertise: Research, design, development and manufacture of industrial wastewater treatment systems, anaerobic and aerobic technologies. Technological expertise: Q, BA Principal products/instrumentation: ADIBVF, industrial wastewater treatment system, anaerobic reactor, aerobic waste treatment system.

29 ADOLF KUHNER AG Add: Dinkelbergerstr. 1 Birsfelden 4127 Switzerland Tel: (41) 61-319-9393 Fax: (41) 61-319-9394 E-mail: [email protected] Web site: www.kuhner.com R&D expertise: Development and manufacture of fermentation products, culture shaking machines and incubator shakers for laboratory and industrial applications. Technological expertise: BA, FE, LC/TC Principal products/instrumentation: Shaking machines, incubator Shakers, fermented products.

30 ADOLOR CORP. Add: 395 Phoenixville Pike Malvern, PA 19355

28 ADI SYSTEMS, INC. Add: 1133 Regent Street Suite 300 Fredericton, NB E3B 3Z2 Canada Tel: (506) 452-7307 Fax: (506) 452-7308 E-mail: [email protected] Web site: www.adi.ca/sys President: Robert Landine Research director: Al Cocci

Tel: (610) 889-5729 Fax: (610) 889-2203 Web site: www.adolor.com President/CEO: John J. Farrar, Ph.D. Research director: Alan L. Maycock, Ph.D. R&D expertise: Development and manufacture of novel analgesics and other therapeutics based on proprietary medicinal chemistry and recombinant receptor technology; bio-pharmaceutical development.

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Technological expertise: D-D, HTDS, RD, SMC, SY Main products/instrumentation under R&D: ADL 2-1294: topical analgesic for burn pain, clinical development research; ADL-2-1294 ophthalmic pain; ADL-8-2698 constipation; ADL 10-0101 post surgical pain, recombinant receptor technology, specific analgesic. Sealed and granted patents: Patents or applications on recombinant opiate receptors, specific opiate agonists or antagonists and their uses.

31 ADVANCE CONSULTANCY SERVICES Add: 189 St. Georges Terrace Ashton Buildings, 8th Floor Perth, WA 6000 Australia Tel: (61) 89-226-4345 Fax: (61) 89-226-4346

R&D expertise: Research and development of animal proprietary drug and biological delivery, jet injection, controlled and pulse release, nasal mucosal powders, stability. R&D collaboration: Cambridge, England.

EastBridge

Ltd.,

Key license and trade contracts: Eastbridge Limited, current negotiations include jet injection and glass technology with two additional companies. Technological expertise: DD Main products/instrumentation under R&D: Combination swine vaccines (custom blended) for jet injection with immediate and pulse release. Nasal aerosol for dogs, animal vaccines, biovine virus diarrhea vaccine, feline rhinotracheitis vaccine, ost-coarthritic formulation and delivery for dogs. Sealed and granted patents: Particle in solution, glasses (pending).

E-mail: [email protected] President: Dass Apanah R&D expertise: Marketing, commercials, contract R&D of biotech medicines and vaccines. Joint ventures: Under review.

33 ADVANCED BIOCONCEPT, LTD. Add: 5375 Pare St. Suite 201 Montreal H4P 1P7 Canada

R&D collaboration: Negotiating with universities for contract R&D.

Tel: (514) 874-5434

Key sales market contracts: Medicine products.

E-mail: mail@bioconcept. com

Technological expertise: COC, G, COS Principal products/instrumentation: Biosensors, antibodies, contract research/development products, natural products, nutraceuticals, vaccines, reagents, enzymes, biologicals.

32 ADVANCED ANIMAL THERAPEUTICS, INC. Add: 860 Knollwood Rd. Deerfield, IL 60015 Tel: (847) 948-0401 Fax: (847) 948-0425 President: James Maki

Fax: (514) 874-9077 Web site: www. bioconcept. com President: Martin Le Blanc Research director: Peter Banks, Ph.D. Joint ventures: NEN Lifescience Products R&D expertise: Research of custom organic synthesis, chemical synthesis of DNA and peptides, HLA DNA typing, protein and peptide-based anticancer therapeutics, peptide instrumentation. R&D collaboration: McGill University, Montreal Neurological Institute, Université du Quebec à Montreal. Technological expertise: CSDP, CS, FL, HDT, COS, PI, P, PIS, PPAT, P/PS, PS/AP

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Principal products/instrumentation: Produced peptides including Fluo-Beta Amyloid(1-42)TM, Fluo-MCHTM, Fluo-VIPTM, Fluo-Endothelin1TM, Fluo-Angiotensin IITM, plus 36 others, all trademarked. Main products/instrumentation under R&D: 30–40 Conjugates, DNA and peptide synthesizer, peptide sequencer, peptide nucleic acid, peptide library, peptinogan analogs.

34 ADVANCED BIOTECHNOLOGIES, INC.

11

gp12 degrees antigen capture; Herpes and Retrovirus monoclonal antibodies. Sealed and granted patents: U.S. patents are pending.

35 ADVANCED CENTRE FOR BIOCHEMICAL ENGINEERING Add: Chem & Biochem Engineering University College London, Torrington Place London WC1E7JE UK Tel: (44) 0171-391-1316 Fax: (44) 0171-916-3943

Add: Rivers Park II 9108 Guilford Rd. Columbia, MD 21046-2701 Tel: (301) 470-3220

CEO: Prof. P. Dunnill Research director: Prof. P. Dunnill

Fax: (301) 497-9773

R&D expertise: Provision of bioprocess research, development and training.

E-mail: [email protected]

Technological expertise: F, M, P/S, BA, CC, BP

Web site: www.abionline.com

Principal products/instrumentation: Specialty Chemicals, contract manufacturing products, industry training programs (MBI training), biosensors, bioprocess technology instrumentations, research in bioprocesses and consulting.

President/CEO: James E. Whitman, Jr., Ph.D, Research director: James E. Whitman, Jr., Ph.D. R&D expertise: R&D/manufacture of largescale viral antigen and cell culture for research and diagnostic kit; protein purification, reagents for AIDS, retroviral and herpes viral research/development.

36 ADVANCED CHEMTECH, INC.

Technological expertise: F, PA, M, Q, BA, C/TC, GA, P/S, RD, G, HTDS

Add: 5609 Fern Valley Rd. Louisville, KY 40228

Principal products/instrumentation: Viral antigens for diagnostic kit, immunoassay stabilizer, stock and customer cell culture, purified viral proteins, retroviral and cellular DNA controls, large-scale plasmid preparations and purification, cultured cells, elutriated cell preparations (human monocytes, lymphocytes), human macrophage and lymphocyte cultures, natural human IL-2, virus quantization, bioprocess monitoring, anti-AIDS and other retroviral drug testing, anti-herpes virus testing, EIA test human retroviruses from patient blood, diagnostic kits: HHV-6 ELISA and IFA, HHV-8 ELISA and IFA, and HIV-1

Tel: (502) 969-0000 Fax: (502) 968-1000 E-mail: [email protected] Web site: www.peptide.com President/CEO: Hossain Saneii, Ph.D. Research director: Hans Tanner R&D expertise: Development of peptide products, peptide instrumentation and services for drug discovery, emphasis on combinatorial, organic and peptide chemistry. Key sales market contracts: Rapp Polymere, Tripos, Inc. Cambridge Scientific Computing.

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Key license and trade contracts: SPAR-50 resin (Baylor University); Chiron Corp. (Library technology).

R&D expertise: Research and development of gene computing technology software.

Technological expertise: CC, COC, R, SMC, CS, D-D, PIS, SY

Principal products/instrumentation: Agriculture, biopharmaceuticals, HYBsimulator oligonucleotide design software, 1995, version 2.0 1997; gene computing technology software.

Principal products/instrumentation: Chemicals, contract manufacturing, instrumentation, pharmaceuticals, B-Amyloids, reagents, Angio Tensins, LH-RH, PTH, ANF, Cgmp, TB4, ANP, BNP, Bulk, Peptides, peptide sequencer, ACT Model Multiple Peptide Synthesizers; Benchmark Series Organic Synthesizers; Labtech Manual Synthesizers; Vantage Combinatorial Synthesizer; Vanguard Semi-Automated Synthesizer; Benchmark organic synthesizers (model 496 MOS, 440 MOS, 354 HTS); Labtech multiple synthesis system; Model 396 MBS, Model348 MPS Synthesizers; ParamaxSynmesisresins; ReactechSynthesizer, peptide scanning technique. Main products/instrumentation under R&D: New synthesizer systems, peptide library, integrated discovery products, data management software, all under development. Subsidiary bodies: Advanced Chem Tech Europe, Nieuwbrugstraat 73, B-1830 Machelen, Brussels, Advanced ChemTech Japan K.K., Segi Building, 7-1, 1-chome, Iwamotocho, Chiyodaku, Tokyo 101, Japan. Sealed and granted patents: Reactor and synthesizer technology pending.

Technological expertise: GA, CH/S, BTS

38 ADVANCED MOLECULAR SYSTEMS Add: 2055 Gateway PL, Suite 400 San Jose, CA95110-1015 Tel: (408) 433-9814 Fax: (408) 433-5925 President/CEO: Martin F. Schroeder Research director: Franklin Sunzeri, Ph.D. R&D expertise: Separations science technology development and manufacture of molecular biology products. Technological expertise: SMC, BC Principal products/instrumentation: Model 2000 capillary electrophoresis system, fingerprinter™ system, molecular exciton microscopy molecular sieve.

39 ADVANCED PRESSURE PRODUCTS Add: 83 Brown Rd, Ithaca, NY 14850 Tel: (607) 257-5544

37 ADVANCED GENE COMPUTING TECHNOLOGIES, INC. Add: 1003 Health Sciences, Rd. West Irvine, CA 92612 Tel: (949) 725-2707 Fax: (949) 725-2708 E-mail: [email protected] Web site: www.hybsimulator.com President/CEO: Masato Mitsuhashi Subsidiary of Hitachi Chemical

Fax: (607) 257-5639 E-mail: [email protected] Web site: www.pmiapp.com President: Krishna M. Gupta R&D expertise: Process control research and related novel products development. Technological expertise: SMC Principal products/instrumentation: Pressure & flow control systems, automated valves, pressure generators & calibration systems, process control technologies.

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40 ADVANCED SCIENTIFICS, INC.

13

41 ADVANCED SEPARATIONS AND PROCESS SYSTEMS, INC.

Add: 163 Research Ln. Millersburg, PA 17061 Tel: (717) 692-2104

Add: 6111 Pepsi Way Windsor, WI 53598

Fax: (717) 692-2197

Tel: (608) 846-1130

Web site: www.advancedscientifics.com

Fax: (608) 846-1140

President/CEO: Kent Smeltz

Web site: www.asapsvs.com

Research director: Carl Martin

President: Bob Cadwalader

R&D expertise: Scientific research of cell and tissue culture; custom manufacture of bag systems and tubing sets, custom injection molding.

R&D expertise: Drug design, development and engineering, custom fabrication of process systems and automation for pharmaceutical/ biotech industries

Technological expertise: C/TC Principal products/instrumentation: Waste bags, media bags (100 ML-200 liters) patented sterile connector system for sterile solution transfer, injection molding (design, build and run), biological safety assessments including assays for viral and other contaminants of mammalian cell and blood-plasma-derived products, analytical methods for protein characterization; a wide range of cGMP and GLP compliant biopharmaceutical and pharmaceutical products including biosafe, analytical, carcinogenicity and toxicology testing, purification process validation, cell line characterization, formulation development, stability and lot release testing services and laboratory animal health services; and cGMP banking and contract manufacturing for microbial products, including recombinant and nonrecombinant bacteria and yeasts, and viral-based products including retroviral, adenoviral and other gene therapy vectors for clinical trials; Large tube clamp utilized to control or stop the flow of the fluid path through a variety of tubing from 0.75′′ OD to 1.75′′ OD (1/8′′ wall). The component is composed of a locking and unlocking feature to enhance versatility. Typical applications of the clamp include use with biopharmaceutical manufacturing and pharmaceutical processes, disposable filtration systems, mixing containers and vessels, and assemblies and tubing sets, 2010. Sealed and granted patents: Sterile connector system.

Technological expertise: F, M, P/S, BA, CH/S Principal products/instrumentation: CIP/SIP systems, Hartel, 1972; Modular package process systems, Hartel, 1972; ASAP Autosoft™ automated, ASAPAutosoft™ 1992; process control system, drug screening program.

42 ADVANCED SEPARATION TECHNOLOGIES Add: 37 Leslie Court, P.O. Box 297 Whippany. NJ 07981 Tel: (973) 428-9080 Fax: (973) 428-0152 E-mail: [email protected] Web site: www.astecusa.com President: Thomas E, Beesley R&D expertise: Unique chromatography phases for chiral separations of biopharmaceuticals. Technological expertise: CC, P/S Principal products/instrumentation: Cyclodextrin bonded HPLC Phases, CYCLOBOND, 1983; macrocyclic glycopeptide bonded HPLC Phases, Chirobiotic, 1994; Cyclodextrin Bonded GC Phases, CHIRALDEX; uniquesequence DNA, chiral separation technology, chiral reagents, antibodies.

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43 ADVANCED SURFACE TECHNOLOGY, INC. Add: 9 Linnell Circle Billerica, MA 018213902 Tel: (978) 670-2544, (978) 663-7652 Fax: (978) 667-9778 E-mail: [email protected]

dopamine beta hydroxylase targeting, 1994; Antibodies for Neuroscience and Endocrinology, 1996; SP-SAP, substance P targeting, 1997. Main products/instrumentation under R&D: Substance P-Saporin as pain treatment, specific targeting reagents. Sealed and granted patents: Substance PSaporin US 6,063,758

Web site: www.astp.com President: Ih-Houng Loh, Sc.D. Research director: Min-Shyan Sheu, Ph.D. R&D expertise: Surface coating/surface modification/surface analysis of drugs. Technological expertise: CH/S, DD, P/S, SY

45 ADVANCED TECHNOLOGY & INDUSTRIAL CO., LTD. Add: Unit B, l/F, Cheong Shing Bldg. 17 Walnut St. Tai Kok Tsui, KW Hong Kong

Principal products/instrumentation: VCA2000 Video Angle System, CellSTAGE™, Biophilic™, ParyLAST™, HydroLAST™.

Tel: (852) 2380-2273

Sealed and granted patents: 5,355,832 Polymerization Reactor; 5,236,563 Surface Modified Bioabsorbables; 5,211,993 Method of Making Novel Separation Media; other U.S. patents are pending; surface intermediate, surface structure analysis.

E-mail: [email protected]

44 ADVANCED TARGETING SYSTEMS Add: 11175-A Flintkote Avenue San Diego, CA 92121 Tel: (858) 642-1988 Fax: (858) 642-1989

Fax: (852) 2789-8314 President/CEO: Wesley Hui R&D expertise: Research and development of laboratory chemicals, laboratory equipment/ apparatus, lab consumables, fine chemicals, biochemicals, process equipment and analyzers. Technological expertise: CC, E, F, PA, M, Q, Y, TE, AF, BA, BS, C/TC, COC, DD, D-D, GA, GT, HTDS, H/CF, PIS, P/S, RD, R, SY Principal products/instrumentation: Laboratory reagents; laboratory consumables, laboratory apparatus, fine chemicals, specialty biochemicals, process scale chromatography, microanalyzers.

E-mail: [email protected] Web site: www.ATSbio.com President: Douglas A. Lappi, Ph.D. R&D expertise: Development, manufacture and marketing of research reagents for specific targeting of cell populations. Technological expertise: C/TC, GT, E, H/CF, PA, RD, SY Principal products/instrumentation: 192lgG-SAP, p75 targeting, 1994; Anti-DBH-SAP,

46 ADVANCED TISSUE SCIENCES, INC. Add: 10933 North Torrey Pines Rd. La Jolla, CA 92037 Tel: (858) 713-7300 Fax: (858) 713-7400 President: Gail K. Naughton, Ph.D. Research director: Anthony Ratdiffe, Ph.D.

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R&D expertise: Research, development and manufacture of human-based tissue culture products for tissue injury repair and transplantation. Joint ventures: Smith & Nephew — 50/50 joint venture — orthopedic cartilage, Dermagraft — diabetic foot ulcers.

15

48 AEA TECHNOLOGY, PLC. Add: Biotechnology Services 353, Harwell Didcot, Oxon OX11 ORA UK Tel: (44) 1235-43-4744/5415 Fax: (44) 1235-43-2997

R&D collaboration: Georgia Tech. — chondrocyte metabolsim.

E-mail: [email protected]; biotechnology@ aeat.co.uk

Key license and trade contracts: University of Florida Research Foundation, Procter & Gamble Co., MIT/ Children’s Hospital Boston.

Web site: www.aeat.co.uk/pes/Biotech

Technological expertise: C, TE, LC/TC

R&D expertise: Development of cell-tissue culture, biotechnology medicines, bioprocessing and bioprocess engineering products contract research.

Principal products/instrumentation: Dermagraft-TC temporary skin covering. Main products/instrumentation under R&D: Dermagraft-Ulcers, Phase III; Orthopedic Cartilage, preclinical; Tissue Engineer Heart Valves, research; temporary skin culture grafts. Sealed and granted patents: #4,721,096; 5,032,508; 5,160,490; 5,266,480; 5,443,950; HEM 44 additional patents, 4,963,489; 5,460,939; 5,510,254; 5,541,107; 5,578,485; 5,518,915; 5,516,681; 5,512,475; 5,516,680.

47 ADVANTEC MFS, INC. Add: 6691 Owens Dr. Pleasanton, CA 94588 Tel: (800) 334-7132 Fax: (925) 225-0353 E-mail: [email protected] Web site: www.advantecrnfs.com President: Y. Matsao Subsidiary of Toyo Roshi Kaisha, Ltd. R&D expertise: Research, development and marketing of filters and filtration apparatus.

President: Dr. A. Nichols Research director: Dr. A. Lewin

Technological expertise: LC/TC, LP, MAE, AT, BP, C/TC, DD, P/S, R, G Principal products/instrumentation: Process scale-up & integration, genetic engineering fermentation, purification, development biosafety, bioaerosol optimization, sampling, process development software, analysis. Services: Confidential contract R&D (bioprocessing, bioseparations), BIOSEP research club, Therapeutic target selection, biologicals, enzymes, vaccines, monoclonal antibodies, healthcare products. Adsorption and chromatography membranes, space biotechnology, assay based on animal cells, solid and liquid effluent treatment using biofilms, bioaerosols, fermentation, cell-line development. Subsidiary bodies: Lab and pilot plants for bioseparations, effluent treatment, and mammalian cell culture; Pilot plant to 120 fermentation & downstream processing.

49 AEF GLOBAL, INC.

Technological expertise: FE, PI, BA Principal products/instrumentation: MFS brand filters-membranes, paper and glass fiber, filtration manifold.

Add: 855, rue Pepin Sherbrooke, Quebec I1C 2P8 Canada Tel: (819) 348-9461

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Fax: (819) 348-9466 E-mail: [email protected] Web site: www.aefglobal.com President: Renaud Lapiere R&D expertise: Development of biopesticides — BT and others; R&D/manufacturing services. Technological expertise: AF Principal products/instrumentation: Agriculture, biological, natural products, biopesticides, pest control operation.

R&D expertise: Research, development, manufacture and commercialization of professional products for the controlled delivery of drugs to the lungs; Pulmonary Drug Delivery. R&D collaboration: PathoGenesis Becton, Dickinson & Co.

and

Technological expertise: DD, DDI Principal products/instrumentation: Pharmaceuticals, contract R&D products, drug delivery route, pulmonary drug delivery method.

52 AERONEX, INC. 50 AERBIO, LTD. Add: 320 N. Walnut St. Bloomington, IN 47404

Add: 6975 Flanders Dr. Suite A San Diego, CA 92121

Tel: (812) 334-1540

Tel: (858) 452-0124

Fax: (812) 334-1285

Fax: (858) 452-0229

E-mail: [email protected]

E-mail: [email protected]

Web site: www.aerbio.com

Web site: www.aeronex.com

President: Michael Jeffers

President/CEO: Jeff Spiegelman

Subsidiary of AerChem

Research director: Jeff Spiegelman

Key sales market contracts: Clinalfa AG Switzerland

R&D expertise: Development/manufacture of ultra high purity fluid/gas delivery systems.

R&D expertise: Development/production of biochemical for clinical application.

Technological expertise: M, P/S

Technological expertise: O, C, CC, E, PI, PA, Y Principal products/instrumentation: Clinicalready bioactive compounds.

51 AEROGEN

Principal products/instrumentation: Stainless steel Buchner funnels, cold traps and vessels. Main products/instrumentation under R&D: Stainless steel cold traps and vessels, ultra high purity fluid/gas delivery systems.

53 AETERNA LABORATORIES, INC.

Add: 1310 Orleans Drive Sunnyvale, CA 94089

Add: 1405, boul du Parc-Technologique Quebec, PQ G1P 4P5 Canada

Tel: (408) 543-2400

Tel: (418) 652-8525

Fax: (408) 543-2450

Fax: (418) 652-0881

Web site: www.aerogen.com

E-mail: [email protected]

President/CEO: Jane Shaw, Ph.D.

Web site: www.aeterna.com

Research director: Robert Fishman, M.D.

President: Eric Dupont, Ph.D.

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Research director: Pierre Falardeau, Ph.D. R&D expertise: Research, development and manufacture of antiangiogenic drugs in oncology, dermatology and ophthalmology. Technological expertise: E, M, P/S, BA, C/TC

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55 AFFINITI RESEARCH PRODUCTS, LTD. Add: Mamhead Castle Mamhead, Execter EX6 8HD UK

Principal products/instrumentation: cartcellbioserum, nat-cell, mdi complex, pre complex.

Tel: (44) 0 1626-891010

Main products/instrumentation under R&D: AC-941/Neovastat (oncology, Phase II & III, AC941/PSOVASCAR (dermatology), Phase II; AC-941/Neoretina (ophthalmology), Phase I.

E-mail: [email protected]

Sealed and granted patents: U.S. patent 5,618,925-extracts of shark cartilage having an antiangiogene activity and an effect on tumor regression.

Research director: Paul W. Sheppard, Ph.D.

Fax: (44) 0 1626-891090 Web site: www.affiniti-res.com President/CEO: Ian M. Varndell, Ph.D. R&D expertise: manufacture of peptide drugs and peptide instrumentation and providing research products for life sciences. Key sales market contracts: Biomol Research Labs, Inc., Cytosignal, Inc.

54 AFFERENT (DISTRIBUTOR), IPC. Add: 2020 S.W. Fourth Ave. Third Floor Portland, OR 97201 Tel: (503) 224-6040 Fax: (503) 223-1494 President/CEO: Kenneth Durant Research director: Ted Johnson Subsidiary of CH2MHill, Ltd. R&D expertise: Full-service research, design and engineering firm specializing in integrated facility and process design, cleanrooms, and validation services.

Technological expertise: PA, CS, SY, PIS Principal products/instrumentation: Reagents for ubiquitin-proteasome research, 1998; pacemaker custom peptide; conjugate and antibody products. Main products/instrumentation under R&D: Reagents for nitric oxide research. Subsidiary bodies: Labs at University of Exeter, UK.

56 AFFINITY BIOLOGICALS, INC.

Joint ventures: Ishfmoto America, IDC Japan.

Add: HCH Research Centre 711 Concession St. Hamilton, ON L8V 1C3 Canada

Technological expertise: RD, P/S, BA, H/CF, C/TC, PMC, CH/S

Tel: (905) 527-2299 ext. 43520

Principal products/instrumentation: Biologicals, pharmaceuticals, diagnostics, food processing methods, specialty chemicals.

E-mail: [email protected]

Main products/instrumentation under R&D: Clean rooms. Subsidiary bodies: Portland, OR; Austin, TX; Pittsburgh, PA; Albuquerque, NM; Pocatello, ID; San Jose, CA; Phoenix, AZ; Dublin, Ireland; Tokyo, Japan.

Fax: (905) 575-2633 Web site: www.affinitybiologicals.com President: Hugh Hoogendoom Research director: Denlse Foulon R&D expertise: Development and manufacture of antibodies and plasmas for research and diagnostics. Technological expertise: PA, P/S

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Principal products/instrumentation: Paired antibodies for EIA, 1989; Factor Deficient Plasmas, 1995; Polyclonal Anti-bodies, polyclonal antibodies, hybrid antibodies, anticardiolipin antibodies.

Technological expertise: F, RD Principal products/instrumentation: Biological, pharmaceuticals, reagents, neutralizing antibodies, antithyroid antibodies. Sealed and granted patents: In phage display of antibodies.

57 AFFINITY BIOREAGENTS, INC. Add: 14818 West 6th Ave. Suite 1OA Golden, CO 80401

59 AFFYMAX RESEARCH INSTITUTE

Tel: (800) 527-4535

Add: 3410 Central Expressway Santa Clara, CA 95051

Fax: (303) 278-2424

Tel: (408) 522-5700

E-mail: [email protected]

Fax: (408) 481-0393

Web site: www.bioreagents.com

Web site: www.affymax.com

President: James Stiehr

President: Russell Howard, Ph.D.

Research director: Phillip Schwartz

Subsidiary of Glaxo Wellcome

R&D expertise: Immunological research and development of reagents for basic research.

R&D expertise: Bio-Pharmaceutical discovery, concentrating on drug discovery, and drug optimization production.

Key license and trade contracts: Numerous academic and research institutions. Technological expertise: PA, PIS Principal products/instrumentation: Monoclonal and polyclonal antibodies, secondary antibodies, recombinant proteins, maleimideactivated carrier proteins and custom polyclonal antibody, anti-centromere antibodies antinuclear antibodies.

58 AFFITECH AS Add: Gaustadlleen 21 Oslo 0349 Norway Tel: (47) 22-95-8758 Fax: (47) 22-95-8358

Technological expertise: COC Principal products/instrumentation: Biopharmaceuticals, contract R&D products. Main products/instrumentation under R&D: Phase II trial of Hematide for blood transfusion in most patients with erythropoietin-induced pure red cell aplasia (PRCA), 2009. Hematide is a synthetic peptidic erythropoiesis stimulating agent. Subsidiary bodies: 3410 Central Expressway, Santa Clara, CA 95051 Sealed and granted patents: Peptides and compounds that bind to the 7,109,299, U.S. IL-5 receptor.

E-mail: [email protected] Web site: www.affitech.com President/CEO: Dr.01eJ.Maruik Research director: Dr. Micheal Braunagel R&D expertise: Research, development and manufacture of human recombinant antibodies for diagnostic and therapeutic purposes.

60 A/F PROTEIN CANADA, INC. Add: P.O. Box 21233 20 Hailett Cres. St. John’s, NF A1A 5B2 Canada Tel: (709) 738-4638 Fax: (709) 738-4644 E-mail: [email protected]

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Web site: www.afprotefn.com President: Dr. Garth Fletcher Research director: Dr. Garth Fletcher R&D expertise: Research and development of biotechnology medicines antifreeze protein uses in the agricultural, food, cosmetic, medical fields and transgenic fish for aquaculture.

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Subsidiary bodies: A/F Protein Canada, 20 Halett Crescent, St. John’s Newfoundland, Canada Al A5B2, Tel: (709) 738-4638; Fax: (709) 738-4644. Sealed and granted patents: Use patents of antifreeze proteins to preserve cells, tissue, organs, transgenic fish for rapid growth.

Technological expertise: PS, P/S, PC Principal products/instrumentation: Purification/separation products of proteins and other biotech medicines, antifreeze professional proteins for the scientific research community and aquaculture industry.

62 AGDIA, INC. Add: 30380 County Rd. 6 Elkhart, IN 46514 Tel: (219) 264-2014 Fax: (219) 264-2153 E-mail: [email protected]

61 A/F PROTEIN, INC.

Web site: www.agdia.com President/CEO: Dr. Chester Sutula

Add: 935 Main St. Waltham, MA 02154

Research director: Dr. Jun Xia

Tel: (781) 899-7755 E-mail: [email protected]

R&D expertise: Reagent research and development; production of diagnostic test kits for the detection of plant pathogens.

Web site: www.afprotein.com

Technological expertise: PA, H/CF, GA

President: Elliot Z. Entis

Principal products/instrumentation: PathoScreen ELISA kits for plant pathogens; PathoScreen ELISA kit for Neomycin Phosphotransferase II; nucleic acid hybridization tests; immunological reagents, detection kits of plant pathogenic bacteria.

Fax: (781) 899-8482

Research director: Garth Fletcher, Ph.D. R&D expertise: Research, development and manufacture of antifreeze proteins and their application, genetically engineered fish development. R&D collaboration: Unilever Key license and trade contracts: Salmond Smith Biolabs (Transgenic Fish), Bioshelter Inc. Technological expertise: PI, P, RD, Q, TE, T

63 AGEN BIOMEDICAL, LTD. Add: 11 Durbell St. Acacia Ridge Queensland 4110 Australia

Principal products/instrumentation: Transgenic fishs, aquadvantage Salmon transgenic for rapid growth.

Tel: (61) 7-3370-6300

Main products/instrumentation under R&D: Hypothermic preservation of blood platelet, preclinical; AquAdvantage Fish — trangenic for viral resistance; enhanced cryosurgery — preclinical.

Web site: www.agen.com.au

Fax: (61) 7-3370-6370 E-mail: [email protected] CEO: Russell Richards (General Manager) Research director: Dr. Michael Gerometta Subsidiary of Agen Limited

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R&D expertise: R&D, manufacturing and marketing of human and animal diagnostics and related technologies. Technological expertise: F, P/S, HTDS, C/TC Principal products/instrumentation: Dimertest Latex and EIA (test for blood dots), diagnostic kits, diagnostic enzymes, diagnostic reagents, VetRED Canine Heart Worm (whole blood assay for detecting canine heart worm), SimpliRED D-dirner (whole blood assay for detecting D-dimer levels), SimpliRED HBsAg (simplified rapid whole blood assay for detecting hepatitis B antigen), witness CHW, FIV and FELV (rapid whole blood assay for detecting feline immune deficiency virus), SimpliDdiner (rapid immunochromatog, D-dimer (rapid immunochromatography test for Ddimer ), AUTO DIMERTEST (automated latex agglutination assay for D-dimer), rapid transtation system, diagnostic agents, diagnostic aid. Sealed and granted patents: D-Dimer monoclonal; Red cell agglutination technology.

Technological expertise: RD Main products/instrumentation under R&D: Lactoferrin, preclinical; recombinant human lactoglobulin, Phase II study of Talactoferrin Alfa, a recombinant form of human lactoferrin, for the treatment of severe sepsis, 2008. Sealed and granted patents: EP 0471011 — Human Lactoferrin cDNA Sequence; U.S. 5571691; U.S. 5571896; U.S. 5571697 — production of recombinant human lactoferrin; intimicrobial/endotoxin neutralizing polypeptide. 6,399,570, U.S.; other patents pending. 65 AGOURON PHARMACEUTICALS, INC. Add: 10350 N.Torrey Pines Rd. La folia, CA 92037 Tel: (858) 622-3000 Fax: (858) 622-3298 Web site: www.agouron.com President/CEO: Peter Johnson Research director: Mike Vamey, Ph.D.

64 AGENNIX, INC. Add: 8 Greenway Plaza, Ste. 910 Houston, TX 77046 Tel: (713) 552-1091 Fax: (713) 552-0795 E-mail: [email protected] Web site: www.agennix.com President: Denis R. Headon, Ph.D. Research director: Samantha Fast (Project Development Manager) R&D expertise: Development/manufacturing scale-up, preclinical and commercial development of recombinant human lactoferrin. Joint ventures: Royal-Gist Brocades N.V. Key license and trade contracts: Baylor College of Medicine.

Subsidiary of Warner-Lambert R&D expertise: R&D of human therapeutics, anti-cancer and anti-HIV; antibodies and antiviral drugs production. Key sales market contracts: Japan Tobacco/nc, Roche. Key sales market contracts: Roche Key license and trade contracts: Roche Technological expertise: SMC, DD, D-D, HTDS Principal products/instrumentation: Viracept, 1997; Rescriptor, anticancer drugs, anticarcinogen. Main products/instrumentation under R&D: AG 3340, Phase III; AG 7088 Phase II; Remune (HIV-immunogen), HIV seropositive, Phase III–IV, 2008; anticancer vaccine, antiviral antibody, antiviral protein. Sealed and granted patents: Viracept

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66 AGOWA GMBH Add: Glienicker Weg 185 Berlin 12489 Germany Tel: (49) 30-670-57238 Fax: (49) 30-670-57228

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Technological expertise: Q, E, T, RD, P/S, GA, C/TC Main products/instrumentation under R&D: Genetically improved soybeans, cotton and other crops, genetically engineered plant, genetically engineered vaccines.

E-mail: [email protected] Web site: www.agowa.de President/CEO: Dr. Rolf Wambutt Research director: Dr. Wolfgang Zirnmermann R&D expertise: Drug products R&D, manufacture and services of molecular biology.

68 AGRAQUEST, INC. Add: 1530 Drew Ave. Davis, CA 95616 Tel: (530) 750-0150 Fax: (530) 750-0153

Technological expertise: Q, BI, G, P/S

E-mail: [email protected]

Principal products/instrumentation: Custom DNA Sequencing products, DNA drug complex, Bioinformatics, ConSequence, 1999; DNA Isolation Kit, AGOWA DNA Isolation Kit; high through-put DNA sequencing (EST’s, Cosmides, BAG, Genome); custom sequencing service; diagnostic sequencing (Mutation analysis) Bioinformatics, ConSequence, kits and automated solutions for nucleic acid purification, DNA detection kit, DNA detection kit, DNA database, DNA purification kit.

Web site: www.agraquest.com

67 AGRACETUS CAMPUS, MONSANTO CO. Add: 8520 University Green Middleton, WI 53562 Tel: (608) 836-7300

President/CEO: Pamela G. Marrone, Ph.D. R&D expertise: Research, development and manufacture of natural pesticide products. Technological expertise: F, BA Principal products/instrumentation: Laginex, “MoquitoLarvicide”, 1997 Main products/instrumentation under R&D: Serenade Biofungicide, market launch 1999; QST776 (3 patents) mosquito repellant, market launch 2000; QST2808 Biofungicide, market launch 2000; QST5595 Biofungicide, market launch 2001. Sealed and granted patents: 12 patents issued (2001); Strain of Streptomyces for controlling plant disease, 6,524,577, U.S. Metabolite from streptomyces strain NRRL accession NO. B30145 and mutants thereof for controlling plant diseases, 6,852,317, U.S. (2008)

Fax: (608) 836-9710 E-mail: [email protected] Web site: www.monsanto.com

69 AGRIFOREST BIOTECHNOLOGIES, LTD.

Research director: Paul Umbeck, Ph.D. Subsidiary of Monsanto Co. R&D expertise: Research, development and manufacture of plant biotechnology products, genetic improvements of crops.

Add: 4290 Wallace Hill Rd. Kelowna, British Columbia VIW 4B6 Canada Tel: (250)764-2224; (604) 764-2224 Fax: (250) 764-2224; (604) 764-2224

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President: Ken Hardy

Web site: www.agritope.com

Research director: Kamlesh Patel, Ph.D.

President/CEO: Adolph J. Ferro, Ph.D.

R&D expertise: Cell and tissue culture; plant tissue culture

Research director: Ry Wagner, Ph.D.

R&D collaboration: Agriculture Canada Key license and trade contracts: Agriculture Canada. Technological expertise: C/TC Principal products/instrumentation: Plant tissue culture: Apple, pear, cherry rootstock, self-rooted cherries, ornamental shrubs, roses, grapes, trees, tissue culture derived fruit root stocks, ornamental shade & flowering trees, landscape plants, roselets, grapes, saskatoons.

70 AGRISERA Add: Box 57 Vannas 91121 Sweden Tel: (46) 935 33033 Fax: (46) 935 33044 E-mail: [email protected] President: Greger Nordlund Research director: Dr. Joanna Porankiewicz R&D expertise: R&D and manufacturing of antibodies and virus, etc. Technological expertise: PA, P/S, C/TC, H/CF Principal products/instrumentation: Biologicals, contract manufacturing products, diagnostics, pharmaceuticals, monoclonal and polyclonal antibodies, attenuated vivus, hepatitis virus.

71 AGRITOPE, INC. Add: 16160 SW Upper Boones Ferry Rd. Portland, OR 97224

R&D expertise: Improved varieties of fruits and vegetables; grapevine nursery, functional genomics and gene discovery and product development. Joint ventures: Superior Tomato Associates, LLC (with Sunseeds Co.); Agrinomics, LLC (with Rhone-Poulenc). R&D collaboration: Vilmorin Clause & Ge; Sweet Briar Development; Ball Horticultural Co.; The Salk Institute for Biological Studies, The Boyce Thompson Inst, Vanwell Nursery, USDA. Key license and trade contracts: The Salk Institute for Biological Studies, Ohio State University; AgraQuest, Inc.; The University of Edinburgh, U.T.I. Technological expertise: E, Q, T, AF, BI, C/TC, CH/S, GA, G, RD Principal products/instrumentation: Disease free grapevine nursery stock; disease testing and elimination services in grapevine. Main products/instrumentation under R&D: Ripening controlled fruits and vegetables, field trials; Disease resistant fruits and vegetables, R&D; Yield enhanced fruits and vegetables, field trials, promoters of apple transgenes expression. Subsidiary bodies: Vinifera Inc., Petaluma, CA, Agritope Wood Bum Field Station. Sealed and granted patents: 5,589,623; 5,416,250; 5,723,743; 5,750,864; 5,859,330; apple promoters for expression of transgenes in plants 6,392,122, U.S.

72 AGRIVIRION, INC.

Tel: (503) 670-7702 Fax: (503) 670-7703

Add: 460 W. 25th St. New York, NY 10001

E-mail: [email protected]

Tel: (212) 463-7325

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Brazil, Australia, South Africa, Japan, India and the Philippines.)

Web site: www.agriviron.com President/CEO: John Lee Compton, Ph.D. R&D expertise: High efficiency contract R&D/ production of recombinant proteins in insect larvae from baculovirus-based expression vectors. Technological expertise: RPP, SI Principal products/instrumentation: Biologicals, contract manufacturing products, reagents, recombinant insect proteins, baculovirus expression vectors. Sealed and granted patents: US #5,351,643 and foreign-High density insert rearing; US #5,593,669 and foreign — Oral infection of insect larvae.

73 AGROL TECHNOLOGIES, LTD. Add: Agrol House, Woodbridge Meadows Guildford, Surrey GU1 1BA UK Tel: (44) 1483-880-450

74 A.G. SCIENTIFIC, INC. Add: 6450 Lusk Blvd. Ste. E102 San Diego, CA 92121 Tel: (858) 452-9925; (877) 452-9925 Fax: (858) 452-9926 E-mail: [email protected] Web site: www.agscientific.com President: Chip Lindgren Research director: Chip Lindgren R&D expertise: Research, development and manufacturing of biochemicals and pharmaceutical raw materials. Technological expertise: PI, CS, HTDS, F, SY, SMC Principal products/instrumentation: Specialty neurochemicals, apoptosis (programmed cell death) reagents, signal transduction pathway, cancer reagents, specialty biochemicals.

Fax: (44) 1483-880-468 E-mail: [email protected]

75 A/G TECHNOLOGY CORP.

President: Prof. B. S. Hartley Research director: Mr. B. Mechsner R&D expertise: Research, development and commercialization of patented thermophilic microorganisms and bioprocesses research to produce chemicals such as ethanol and lactic acid. Technological expertise: E, F, M, Q, BI, BA, CH/S, G, P/S, RD

Add: 101 Hampton Ave. Needham, MA 02494-2628 Tel: (781) 449-5774; (800) 248-2535 Fax: (781) 449-5786 E-mail: [email protected] Web site: www.agtech.com President: A Go Ran, D.Sc.

Main products/instrumentation under R&D: Thermophilic microorganisms/thermophile, improvement and development; fermentation processes, lab and pilot-scale development.

R&D expertise: Research and development of bio-separations utilizing membrane technology specializing in hollow fibers.

Sealed and granted patents: US5182199: Thermophilic ethanol production in a twostage closed system. (Also patented in the EU,

Principal products/instrumentation: Cross flow hollow fiber microfilter, cross flow fiber ultrafiltration and micro filtration membrane

Technological expertise: P/S

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cartridges and systems for bioprocessing: MidGee™ Cross Flow Filters Xampler™ cartridges for laboratory scale applications; MaxCelF™ and Procell™ large process scale cartridges for production scale applications; VirA/Gard™ viral removal membranes. Midler™ Cross Flow Filtration System to replace stirred cells and conventional dialysis for small volume applications; QuixStand™ Benchtop System for rapid concentration/ diafiltration of up to 10 liters; FlexStand Benchtop Pilot System for processing 5 to 100+ liters; Grandstand™ Pilot/Process System for processing 50 to 1000+ liters. AVER point-of-use air separation system for oxygen enriched air to enhance fermentation and nitrogen enriched air for USP water/WFI blanketing.

76 AIDLAB, INC.

77 AKKADIX CORPORATION Add: 11099 North Torrey Pines Road Ste. 200 La Jolla, CA 92037 Tel: (858) 646-8222 Fax: (858) 625-0158 Web site: www.akkadix.com President: Gary H. Richardson Research director: Leo Kim, Ph.D. R&D expertise: Agriculture biotechnologydiscovery research of new agricultural products that will positively impact our day-to-day lives. Technological expertise: Q, BI, RD, C/TC, G Principal products/instrumentation: Agriculture, veterinary products, agrobiological, new agricultural products. 78 ALABAMA RESEARCH AND DEVELOPMENT

Add: P.O. Box 538 Markham, ON L3P 3R1 Canada

Add: 152 Metal Samples Rd. Munford, AL 36268

Tel: (905) 294-1500

Tel: (256) 358-0460

Fax: (905) 471-0322

Fax: (256) 358-4515

E-mail: [email protected]

E-mail: [email protected]

President: D. Ian M. Kerr

Web site: www.alspi.com

R&D expertise: Research of molecular biology, immunology and cytogenetics, related novel products development.

President: Sai Mudiam

Key sales market contracts: Manufacturers representatives for Erie Scientific and Interglass Inc. Technological expertise: SMC, CS, PC Principal products/instrumentation: AIDLAB laboratory products, AIDPAK glass and plastic packaging products. Subsidiary bodies: Scarborough, 3 Pullman Court, Scarborough, ON Canada M1X 1E4; Woodbridge, 461 Hanlan Rd., Woodbridge, ON Canada L4L 3T1.

R&D expertise: Research of cell/tissue culture. Development and manufacture of in-vitro toxicology testing products. Technological expertise: C/TC Principal products/instrumentation: In-vitro toxicology testing products Krumdieck Tissue Slicer, in vitro toxicology testing products. 79 ALBANY MOLECULAR RESEARCH, INC. Add: 21 Corporate Circle PO Box 15098 Albany, NY 12212-5098

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Tel: (518) 464-0279

Research director: Sandra Katz

Fax: (518) 464-0289

R&D expertise: Research, development and provide to biotechnology companies using fermentation processes. Manufacture and co-development of veterinary vaccines.

E-mail: [email protected] Web site: www.albmolecular.com President: Donald E. Kuhla, Ph.D. Research director: Michael P. Trova, Ph.D. R&D expertise: Specialty biochemical contract research organization, products development. Joint ventures: Organichem Corporation. R&D collaboration: Cambrex Corporation. Key sales market contracts: Sphinx Pharmaceuticals (a division of Eli Lilly & Co.), Eli Lilly, Pfizer, DuPont.

Key license and trade contracts: SYNSORB Biotech, Inc.; Biotransplant, BTG USA, Inc. Technological expertise: F, BI, S, SMC, SY, RD, C/TC, F, L, oligosaccharide (scale-up production), immunology, chemistry. Principal products/instrumentation: Specialty biochemicals, vaccines, enzymes, biologicals, reagents, antibodies.

Key license and trade contracts: Hoechst Marion Roussel, Inc.

81 ALC, A DIVISION OF JOUAN, INC.

Technological expertise: CC, E, D-D, COC, SMC, SY, CS

Add: 170 Marcel Dr. Winchester, VA 22602

Principal products/instrumentation: Fully integrated chemistry outsourcing company offering medicinal chemistry, chemical development, enzymatic acylation agent, specialty biochemicals, eGMP synthesis and analytical research services. Subsidiary bodies: Syracuse, NY; Iowa City, IA. Sealed and granted patents: U.S. 5,750,703; U.S. 5,663,412; US. 5,578,610; U.S. 5,581,011; U.S. 5,589,487; Two-step enzymatic acylation, 6,261,813, U.S.

80 ALBERTA RESEARCH COUNCIL, BIOTECHNOLOGY

Tel: (800) 662-7477 Fax: (540) 869-5904 President: Lyle E. Cady, Jr. R&D expertise: Research, development and manufacture of Centrifuges and related products. Technological expertise: P/S, PIS, C/TC Principal products/instrumentation: Centrifuges, centrifuge tube, centrifuge rotor.

82 ALCIDE CORPORATION Add: 8561 154th Avenue NE Redmond, WA 98052 Tel: (425) 882-2555 Fax: (425) 861-0173

Add: 250 Karl Clark Rd. Edmonton, Alberta T6N IE4 Canada

E-mail: [email protected]

Tel: (780) 450-5359

President/CEO: Joseph A. Sasenick

Fax: (780) 465-0744

Research director: G. Kere Kemp

E-mail: [email protected] Web site: www.biotech.arc.ab.ca

R&D expertise: Research, development and manufacture of antifugals/antifungal agents.

President: Walt Leps, Ph.D.

Technological expertise: AF

Web site: www.alcide.com

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Principal products/instrumentation: Exspor, 4XLA, Pre-Gold, Uddergold, Uddergold Plus. Main products/instrumentation under R&D: h5G1.1 Mab, treat membranous nephritis, rheumatoid arthritis lupus, Phase II.

84 ALEXION PHARMACEUTICALS, INC. Add: 25 Science Park, Suite 360 New Haven, CT 06511 Tel: (203) 776-1790 Fax: (203) 772-3655 Web site: www.alexionpharm.com

83 ALERCHEK, INC. Add: 203 Anderson St. Portland, ME 041012548 Tel: (207) 775-2574 Fax: (207) 775-0594 E-mail: [email protected] Web site: www.nlbbs.com/~alerchek/alerchek. htm President/CEO: Wayne M. Henry R&D expertise: Research and development of immuno diagnostics, related novel products manufacture. Technological expertise: BC, COC, CS, CSDP Principal products/instrumentation: Total Human IgG Microwell ELISA, 1995; Total Human IgA Microwell ELISA; Total Human IgM Microwell ELISA; Total Human IgE Microwell ELISA; Allergen Specific Human IgE Microwell ELISA >400 allergens; Allergen Specific Canine IgE Microwell ELISA >400 allergens; Allergen Specific Feline IgE Microwell ELISA >400 allergens; Apolipoprotein AI Microwell ELISA; Apolipoprotein B Microwell ELISA; Lipoprotein (a) Lp(a) Microwell ELISA; TMB/Peroxide HRP Liquid Substrate; HRP Conjugate Stabilizer, Dilutabody Plus; Contract Microwell Coating, immunodetection kits, immunodiagnostic reagents. Main products/instrumentation under R&D: Antibiotic Severe Hypersensitivity Microwell ELISA Tests.

President/CEO: Dr. Leonard Bell Research director: Dr. Stephen Squinto R&D expertise: R&D production of immunoregulatory biopharmaceuticals directed targeting autoimmune and cardiovascular disorders and organ transplants. R&D collaboration: Southeast Wisconsin Blood Center, University of Erlangen (Germany), SUNT, NIAID, Austin Research Institute, U.S. Surgical Corp. Key license and trade contracts: Oklahoma Medical Research Foundation (OMRF), Yale University, AMRAD Corp., Biotechnology Research and Development Corp. (BRDC), NIH Technological expertise: F, Q, T, RD, P/S, C/TC, SY, DD, GT Principal products/instrumentation: Eculizumab (soliris), CAS 219685-50-4 Main products/instrumentation under R&D: Treatment targets (preclinical) for 2007. Autoimmune disease, reperfusion injury; xenographs for organ transplants, rheumatoid arthiritis, Lupus Nephritis surgical bleeding in cardiopulmonary bypass, multiple sclerosis, diabetes mellitus, myasthenia gravis, retroviral gene therapy, myocardial infarction, and stroke; Soliri (eculizuma) for treatment of paroxysmal nocturnal hemoglobinuria to reduce 2007 hemolysis; monoclonal antibody, for rheumatoid arthritis, Phase II/III; for psoriasis, phape II. Sealed and granted patents: Nested oligonucleotides containing a hairpin for nucleic acid

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amplification, 6,919,189, U.S.; Phagemid vectors, 6,803,230, U.S.

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Key sales market contracts: International distributors; mainly in Europe. Key license and trade contracts: MIT, UMASS, Stanford.

85 ALEXIS CORP. Add: 6181 Cornerstone Ct. East, Suites 102104 San Diego, CA 92121-4727 Tel: (858) 658-0065, (800) 900-0065 Fax: (858) 658-9224; (800) 900-9224 E-mail: [email protected] Web site: www.alexis-corp.com President/CEO: Dr. Georges Chappuis R&D expertise: Development/manufacture of biochemical and immunochemical for the Life Science Reagents Key sales market contracts: Fisher Scientific

Technological expertise: E, PA, RD, P/S, H/CF, GT Principal products/instrumentation: Medical diagnostic kits for GI infections, total products are now on market; Prospect T; 1989. Main products/instrumentation under R&D: GI bacterial such as salmonella, shipara; virus such as astrovirus and norwalk virus, parasites Dientamoeba fragilis. Subsidiary bodies: Headquarters: 14000 Unity St., NW, Ramsey, MN 55303-9115 Sealed and granted patents: GSA 65 (Giardia lamblic), other patents are pending.

Technological expertise: PA, SMC Principal products/instrumentation: Apoptosis, Cytokines, Immunology Neurochemicals, Nitric Oxide Pathway, Signal transduction and Cell Trafficking. Subsidiary bodies: Alexis Corp., Switzerland; Alexis, U.K.; Alexis, Germany.

87 ALFACELL CORP. Add: 225 Belleville Ave. Bloomfield, NJ 07003 Tel: (973) 748-8082 Fax: (973) 748-1355 E-mail: [email protected]

86 ALEXON-TREND, INC. Add: 601 West California Ave Sunnyvale, CA 94086 Tel: (408) 328-6080 Fax: (408) 328-6087 E-mail: [email protected] President: David Taus Research director: Zong-e Xia Subsidiary of Sybron Int. R&D expertise: Research, development and manufacture of medical diagnostic drugs for GI infections. R&D collaboration: IW Biomedical Inc.

Web site: www.alfacell.com President/CEO: Kuslima Shogen R&D expertise: Discovery, research and development/marketing of a new class of anticancer drugs from amphibian ribonucleases (RNases). R&D collaboration: National Institutes of Health (NINDS&NCI). Technological expertise: RD, D-D, DDI Main products/instrumentation under R&D: ONCONASE — Phase III/IV Sealed and granted patents: Two U.S. patents issued in 1989 for composition of matter & manufacturing method; two counterpart European patents issued in 1994.

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88 ALFA LAVAL

Fax: (14) 20-19-33 E-mail: [email protected]

Add: 955 Mearns Rd. Warminster, PA 18974

President: Oscar Fernandez Anchendo

Tel: (215) 443-4000

Research director: Claudia Juarez

Fax: (215) 443-4112

R&D expertise: Feed design, develop and manufacturing.

Web site: www.alfalaval.com President: Urban Svensson R&D expertise: Research, development and manufacture of centrifugal separation systems. Technological expertise: P/S, PI, SI Principal products/instrumentation: Alfa Laval Sharpies Supers — tubular bowl centrifuges, Alfa Laval Sharpies Super-D-Canters, decanter centrifuges, other centrifugal separation systems.

89 ALFA LAVAL FLOW, INC.

R&D collaboration: Universidad Autinoma de Chihuahua. Key sales market contracts: Farmland, Inc., Godbold, Inc. Technological expertise: BA Principal products/instrumentation: Equus, 1996; Capi-Can, 1997. Main products/instrumentation under R&D: new feed.

91 ALIZYME PLC

Tel: (800) 558-4060

Add: 280 Science Park Milton Road Cambridge CB4 OWE UK

Fax: (414) 694-2907

Tel: (44) 1223-423-070

President: Keith Potts

Fax: (44) 1223-423-818

Research director: Mark Ream

E-mail: [email protected]

Subsidiary of Alfa Laval

Web site: www.alizyme.com

R&D expertise: Research, design and manufacture of Full-line pumps and related valves.

President/CEO: Dr. Richard Palmer

Add: Pleasant Prairie, WI 53158-0909

Technological expertise: M, BI Principal products/instrumentation: Sanitary pumps, professional valves, & fittings-water for injection pumps, microbiological sampling valves.

R&D expertise: Drug discovery, research, design and development for obesity, diabetes, gastrointestinal diseases and mucositis, related novel products manufacturing. R&D collaboration: SmithKline Beecham, Oxford Molecular Group, Peptide Therapeutics Ltd., Imperial College of Science, Technology and Medicine; University of Birmingham.

90 ALIMENTOS CONCENTRADOS DE CHIHUAHUA S.A.

Key license and trade contracts: British Technology Group, University of Strathclyde, Rowett Research Institute.

Add: Blvd. Fuentes Mares # 1000 Codigo Postal 31050. Apartado Postal F-2 Chihuahua, Chih. 31050 Mexico

Technological expertise: COC, DDI, D-D, HTDS, RD, SMC, SY

Tel: (14) 20-99-33

Main products/instrumentation under R&D: ATL-1251 for irritable bowel syndrome, Phase II;

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ATL-2502/Colal for inflammatory bowel disease, Phase II; ATL-962 for obesity; ATL-101 for mucositis, Preclinical; Colal; colonic drug delivery system; gastrone.

92 ALKAMI BIOSYSTEMS Add: PO Box 11216 Berkeley, CA 94712-2216 Tel: (510) 665-9683

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Technological expertise: GT, DD, SY, C/TC, H/CF, RD Main products/instrumentation under R&D: Medisorb-Risperdal human growth hormone, treat schizophrenia, in clinical trials; Cereport (RMP-7)/Carboplatin, treat recurrent malignant cerebroma, Phase III: ProLease/hGH, preclinical; ProLeaseVIntron A, preclinical; ProLease/undisclosed molecule, preclinical. Subsidiary bodies: Alkermes Europe, Ltd.

Fax: (510) 849-2148 E-mail: [email protected] Web site: www.alkami.com President: Lisa Stewart R&D expertise: Design and development of biological software & consulting; Research and manufacture of biotechnological medicines. Key sales market contracts: United Scientific Products, Axygen Scientific.

94 ALL CELLS, LLC. Add: 2500 Milvia St., Ste. 214 Berkeley, CA 94704 Tel: (510) 548-8908 Fax: (510) 548-8327 E-mail: [email protected]

Technological expertise: BI, CH/S, GA, GT

Web site: www.alllcells.com

Principal products/instrumentation: Alkami Bios/stems, 1998; Alkami PCR.

President/CEO: Jay Tong

Main products/instrumentation under R&D: Sequence Analysis, Beta Testing, discovery software of biotech medicines.

93 ALKERMES, INC. Add: 64 Sidney St. Cambridge, MA 02139 Tel: (617) 494-0171 Fax: (617) 494-9255 Web site: www.alkermes.com President: Robert Breyer Research director: Jim Wright R&D expertise: Development, manufacture and commercialization of high efficiency products based on drug delivery technologies. R&D collaboration: Schering-Plough; Genetech; Boeringer Mannheim. Key license and trade contracts: Cortex Pharmaceuticals, calgain inhibitors.

R&D expertise: Development/manufacture of blood substitutes cells, and tissue culture. Technological expertise: BA, BS, C/TC, GT, G, TE Principal products/instrumentation: Human primary cells, human bone marrow cells, human peripheral blood cells (including GCSF mobilized peripheral blood cells), human cord blood cells, human CD34+ cells, human immunological cells (CD4, CD8, CD14, CD19, etc.) Human primary cell culture including human hematopoietic colony assay, cell and tissue culture products, other blood substitutes.

95 ALLELIX BIOPHARMACEUTICALS, INC. Add: 6850 Goreway Dr. Mississauga, Ontario L4V 1V7 Canada Tel: (905) 677-0831

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E-mail: [email protected]

Key license and trade contracts: Chiron Corp for certain infectious disease vaccines.

Web site: www.allelix.com

Technological expertise: DD, D-D

Fax: (905) 677-9595

President: G. Strachan R&D expertise: Research, development and manufacture of bio-pharmaceuticals. Joint ventures: Resolution Pharmaceuticals Inc. R&D collaboration: Eli Lilly; Nordion International; University of Toronto; Hoechst; Fournier. Key license and trade contracts: Numerous Canadian universities Technological expertise: RD, D-D, CH/S, HTDS, R, SMC, P/S, BA, GA, C/TC, SY Main products/instrumentation under R&D: ALXI-II, Recombinant human Parathyroid hormone (PTH) for osteoporosis in (Phase III); GLP-2 for gastrointestinal disorders; ALX0600, Analog of Glucagon-like peptide 2, an intestinal growth factor (Phase I); ALX-064S, Serotonin receptor agonists for treating migraine (Phase II); ALX-5407, Glycine reuptake inhibitor for treating schizophrenia and dementia, Preclinical; Dopamine transporter antagonists; Cognition enhancers; Novel analgesics; EAA receptor modulators, vaccines, enzymes, antibodies.

Main products/instrumentation under R&D: Ragweed for: Allergy, Phase II; Tetanus, Phase I; Grass Allergy, Phase I; Cancer, Preclinical. Sealed and granted patents: 5 in U.S. on core technology, all uses, composition, manufacture and use. 97 ALLERGY IMMUNO TECHNOLOGIES, INC. Add: 1527 Monrovia Ave. Newport Beach, CA 92663 Tel: (949) 645-3703 Fax: (949) 722-6674 E-mail: [email protected] Web site: www.biomerica.com President/CEO: J. Kaslow, J.H. Irani Subsidiary of Biomenca R&D expertise: Development and manufacture of allergy treatment (patented) drug using liposomes, reference lab research services. Technological expertise: DD, D-D Main products/instrumentation under R&D: Treatment for allergies using liposome encapsulated allergens, new therapeutics for allergic disease.

96 ALLERGENICS, INC. 98 ALLEXCEL.COM, INC. Add: 500 Airport Blvd. Ste. 100 Burlingame, CA 94010-1914

Add: 135 Wood St. West Haven, CT 06516

President: Clint G. Dederick, Jr.

Tel: (203) 937-6137

Research director: Lindsey Wood, Ph.D.

E-mail: [email protected]

R&D expertise: Research and development of oral delivery vaccines for allergy, infectious diseases and cancer.

Web site: www.allexcel.com

R&D collaboration: CRADA with NCI for cancer vaccines. Clinical trial agreement with NIH for tetanus vaccine.

R&D expertise: Research and manufacture targeted Encapsulated Drug Delivery, anti-HIV and Anti-Cancer Drugs.

President:.Anil Diwan, Ph.D. Research director: Dr. Arthur Watterson

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Joint ventures: seeking. R&D collaboration: Massachusetts.

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University

of

Fax: (49) 3371-68-1165 E-mail: [email protected]

Key sales market contracts: SciQuest, inc.

Web site: www.alphabvt.com

Key license and trade contracts: seeking.

President: Dr. Mathias Schroedter

Technological expertise: AB, BA, CH/S, DD, D-D, F, GA, HTDS, Q, TE, H/CF, RD, SY, SMC, PIS, PG, E

R&D expertise: Custom fermentation engineering research of recombinant (-S2) and nonrecombinant organisms.

Main products/instrumentation under R&D: Encapsulated drug delivery technology, Anti-HIV Drugs (research), anticancer drugs, preclinical.

Technological expertise: F, P/S, H/CF, C/TC, BA, FE

Sealed and granted patents: Pending Patents on Chemical Composition, Utility, and Processes.

99 ALLIED-SIGNAL, INC. BURDICK & JACKSON Add: 1953 S. Harvey St. Muskegon, MI 49442 Tel: (800) 368-0050 Fax: (1616) 725-6216 Web site: www.allied-signal.com President: Fred Lynch Research director: James T. Przybytek Subsidiary of AlliedSignal R&D expertise: Development of high purity solvents and DNA reagents; contract research for protein biophysical characterization, protein purification and protein stabilization. Technological expertise: CC, AB, COC, GT, G, PIS, P/S, RD, SY Principal products/instrumentation: High purity and low water solvents, DNA reagents, B & J BioSyn, 1996; purified protein derivative, protein purified products, DNA purification kits.

100 ALPHA BIOVERFAHRENSTECHNIK GMBH Add: Im Biotechnologiepark TGZ Luckenwalde 14943 Germany

Principal products/instrumentation: Toxicity Test Kit, AlphaTox, fermentation engineering products.

101 ALPHAGENE, INC. Add: 260 West Cummings Park Woburn, MA 01801 Tel: (781) 933-5424 E-mail: [email protected] Web site: www.alphagene.com President/CEO: Donald J. McCarren, Ph.D. Research director: Peter Schad, Ph.D. R&D expertise: Genomics and Neurological Research. R&D collaboration: New Life Sciences. Technological expertise: R, GN, BI, GA, HTDS, RD, S Principal products/instrumentation: Full Length Genes, Flex, Gene Expression, MicroArray, Gene & Protein Discovery, biologicals, human genome project. Sealed and granted patents: Full Length Gene Patents-5,162,209 & 5,643,766.

102 ALPHA INNOTECH CORP. Add: 14743 Catalina St. San Leandro, CA 94577

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Tel: (510) 483-9620

104 ALPHA THERAPEUTIC CORP.

Fax: (510) 483-3227 Web site: www.alphainnotech.com

Add: 5555 Valley Blvd. Los Angeles, CA 90032

President: Darryl Ray

Tel: (323) 225-2221

R&D expertise: Development of digital imaging systems, computer hardware & software for life science research, product manufacture.

Fax: (323) 227-7689

Technological expertise: CH/S, AU

President/CEO: Ralph Galustian

Principal products/instrumentation: ALPHAIMAGER; CHEMIIMAGER; MULTIIMAGE; FA-1000 FAILURE ANALYSIS; SPECTRAIMAGER; ALPHAS-CAN; FluorChem; Chemilmager; Alphamager; AlphaEase.

Research director: fames Pennington, MD

E-mail: [email protected]

E-mail: [email protected] Web site: www.alphather.com

Subsidiary of Yoshitomi Pharmaceutical Industries, Ltd. R&D expertise: Development of blood substitute products and plasma derived therapies. Technological expertise: P/S

103 ALPHAONE PHARMACEUTICALS, INC. Add: 850 Marina Village Parkway Alameda, CA 94501 Tel: (510) 337-1250 Fax: (510) 337-1251 E-mail: [email protected] Web site: www.alphaonepharm.com President: Philip J. Barr, Ph.D. Research director: Philip J. Barr, Ph.D. R&D expertise: Development and manufacture of protease inhibitors for therapeutic applications. R&D collaboration: Baxter Healthcare Corporation.

Principal products/instrumentation: Alphanate Antihemophilic Factor (Human), Solvent Detergent/Heat Treated; AlphaNine SD Coagulation Factor LX (Human) Solvent Detergent Treated/Virus Filtered; Profilnine SD Factor LX Complex, Solvent Detergent Treated; Venoglobuiin S Immune Globulin Intravenous (Human), Solvent Detergent Treated, 5% and 10% solutions; Albutein Albumin (Human), 5% and 25% solutions. Main products/instrumentation under R&D: Alpha (1) proteinase inhibitor for treatment of alpha (1) proteinase inhibitor deficiency (hereditary emphysema), Phase III; Circulase (AS-013 in lipid emulsions) for prevention of limb amputation in patients with severe ischemia, Phase III/IV: NM-702, intermittent claudication. Phase I/II.

Technological expertise: F, P, G, RD Main products/instrumentation under R&D: Recombinant alpha 1-antitrypsin, preclinical, protease inhibitors. Sealed and granted patents: Manufacture and use of recombinant alpha 1-antitrypsin & other serine protease inhibitors in a wide range of clinical indications.

105 ALTA GENTICS INS. Add: Box 12, RR4, Site 12 Calgary, Alberta T2M 4L4 Canada Tel: (403) 239-8882 Fax: (403) 239-8886 Web site: www.altagenetics.com

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President/CEO: Douglas G. Blair

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107 ALTEON, INC.

Research director: Ted Mitenko R&D expertise: Improvement of animal production systems by use of highest quality genetics and reproductive technologies. R&D collaboration: University of Calgary (molecular biology: IVF). Contract unit of license trade: University of Calgary; FII. Hoffmann-LaRoche. Technological expertise: C/TC Principal products/instrumentation: High quality livestock genetics (beef and dairy) sold as semen, embryos, live cattle; technology transfer in embryo transfer field including ultrasonography, DNA probes for early sex determination. Main products/instrumentation under R&D: IVF system for embryo production, animal production systems.

106 ALTAREX CORP.

Add: 170 Williams Dr. Ramsey, NJ 07446 Tel: (201) 934-5000 Fax: (201) 934-8880 Web site: www.alteonpharma.com President/CEO: Ken Moch R&D expertise: Development of therapeutics for complications related to diabetes and aging. Joint ventures: Yamanouchi Pharmaceuticals. Ltd., Gamida, Boehringer Mannheim Diagnostics. R&D collaboration: Yamanouchi pharmaceutical Co., Ltd; Boehringer Mannheim Diagnostics; Picower Institute for Medical Research. Key sales market contracts: Yamanouchi Pharmaceutical Co., Ltd; Boehringer Mannheim Diagnostics; Gamida. Key license and trade contracts: Yamanouchi Pharmaceutical Co., Ltd; Boehringer Mannheim Diagnostics; Picower Institute for Medical Research, Gamida.

Add: 303 Wyman St. Suite 125 Waltham, MA 02154

Technological expertise: C, D, N, H, PA, R, Q, SM, Y, TE

Tel: (781) 672-0138

Main products/instrumentation under R&D: Pimagedine: Phase III tests kidney disease in diabetes — Type II; Phase III/IV kidney disease in diabetes — Type III; Endstage Renal Disease; Dyslipidemia, therapeutics for diabetes complication.

Fax: (781) 672-0142 E-mail: [email protected] Web site: www.altarex.com President/CEO: Richard Bagley Research director: Birgit Schultes R&D expertise: Cancer Immunotherapy development.

Sealed and granted patents: Pimagedine, A.G.E. Breakers Glucose lowering agents, 2nd generation formation inhibitors.

Key license and trade contracts: Biomira Inc. Technological expertise: H/CF, C/TC

108 ALTHEA TECHNOLOGIES, INC.

Main products/instrumentation under R&D: Ovarex, Phase II & IIb, clinical trials; Brevarex, Phase I; Givarex, Discovery Vaccines.

Add: 11040 Roselle street San Diego, CA 92121-1205

Subsidiary bodies: Edmoton, Alberta.

Fax: (858) 882-0133

Tel: (858) 882-0123

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E-mail: [email protected] Web site: www.altheatech.com President: Magda Marquet, Ph.D.

Sealed and granted patents: US #5,618,710; Stabilized protein crystals formulations containing them and methods of making them, 6,541,606, U.S.; other patents pending.

Research director: Francois Ferre R&D expertise: Specialized research and development services (gene quantification & plasmid production) and products for the clinical research and drug development market; GLP contract testing and GMP manufacturing.

110 ALZA CORPORATION Add: P.O. Box 7210 1900 Charleston Rd. Mountain View, CA 94039-7210

Technological expertise: F, G, Q, F, C/TC, CH/S, GA, GT, PG, P/S, BA

Tel: (650) 564-5222

Principal products/instrumentation: Gene quantification services, 1998; Quantitative PCR services, 1998; Plasmid DNA production services 1998.

Web site: www.alza.com

109 ALTUS BIOLOGICS, INC.

Fax: (650) 564-5121 Presidenty/CEO: Dr. Ernest Mario Research director: Dr. Felix Theeuwes R&D expertise: To commercialize products based on Alza’s drug delivery technologies, drug products marketing and sales. Technological expertise: DD

Add: 625 Putnam Ave. Cambridge, MA 02139-4211 Tel: (617) 577-6500 Fax: (617) 577-6480 E-mail: [email protected] Web site: www.altus.com President: Peter Lanciano Research director: Dr. Alex Margolin R&D expertise: Research of peptide synthesis, chiral chemistry and biocatalysis; Biotechnology medicines development. R&D collaboration: Burroughs Wellcome, Sandoz, Nagase Chemicals, Ciba-Geigy.

Principal products/instrumentation: OROS Chlorpheniramine (OTC anti-allergy); Alzet infiasion pumps for laboratory research; Transdermal patch delivery systems; Acutrim appetite suppressant. Main products/instrumentation under R&D: OROS product for severe chronic pain, in development; Transdermal system for urinary urge incontinence, in development; inhalant for osteoporosis, in development; Alza’s drug delivery technologies.

111 AMANO ENZYME EUROPE, LTD.

Technological expertise: CC, E, BA, DD, SMC, SY, P/S, SAADP, PS/AP

Add: 2-7, 1-Chome, Nishin Naka-ku, Nagoya 460-8630 Japan

Principal products/instrumentation: Chiro CLEC catalysts for chiral resolution, CLEC, 1995–1996; Pepti CLEC catalysts for peptide synthesis, Syntha CLEC catalysts for antibiotic synthesis, biocatalyst, stabilized protein crystals.

Tel: (81) (0) 52-211-3032 Fax: (81) (0) 52-211-3054 Web site: www.amano-enzyme.co.jp President: M. Amano Sr. Research director: Mr. Asami

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R&D expertise: Research, development and manufacture of food, Pharmaceutical and diagnostic enzymes. Technological expertise: CC, E, F, CB Principal products/instrumentation: Specialty Enzymes, Amano; Umanizyme, 1999; Maltotriose Enzyme, AMI; diagnostic enzymes, protein tyrosine kinase. 112 AMANO ENZYME USA CO., LTD. Add: 1157N. Main St. Lombard, IL 60148 Tel: (630) 953-1891, 800-446-7652 Fax: (630) 953-1895

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Tel: (806) 376-1741 Fax: (806) 376-9301 E-mail: [email protected] Web site: www.amarbio.com President/CEO: Joseph M. Cummins Research director: Philip C. Fox R&D expertise: Research, development and manufacture of oral interferon and various cytokines. R&D collaboration: Hayashibara Biochemical Laboratory, Japan. Key sales market contracts: Mitsubishi Corporation.

Web site: www.amano-enzyme.co.jp

Key license and trade contracts: Hayashibara Biochemical Labs, Interferon Sciences, Inc., North China Pharmaceutical Global Damon.

President: Torn Okumura (London office)

Technological expertise: P/S, DD, C/TC, CS

E-mail: [email protected]

Research director: Setsuko Jolly (Nagoya office) Subsidiary of Amano Pharmaceutical Co., Ltd. (Japan) R&D expertise: Enzymology and enzyme reactor technology research, enzymes manufacture.

Main products/instrumentation under R&D: Low dose oral interferon alpha, Phase II/III; interferon alpha, Phase IV, 2008. Veldona (natural human IF-α), treat Sjogren’s syndrome and fibromuscular pain syndrome, Phase III. Sealed and granted patents: 19 U.S. Patents.

Technological expertise: E, ERT Principal products/instrumentation: Enzymes for food and industrial use (amylase, protease, cellulase, lipase); enzymes for diagnostic reagents (glucose oxidase, cholesterol oxidase); enzymes for chiral transformations, enzymecontaining food material, D-aminoacylase. Sealed and granted patents: Enzyme in a dosage form for oral use in mammals, enzymecontaining food material and method for administering the enzyme in a dosage form. 6,699,496, U.S.; Transformed microorganism and process for producing D-aminoacylase. 6,943,004, U.S.; others are pending. 113 AMARILLO BIOSCIENCES, INC. Add: 800 West 9th Ave. Amarillo, TX 791013206

114 AMBERGENE CORPORATION Add: 87I Industrial Road San Carlos, CA 94070 Tel: (415) 802-8543 President/CEO: Robin Steele Research director: Raul Cano, Ph.D. R&D expertise: Drug Discovery, design and development of Antiinfectives. Joint ventures: Merck, Procter & Gamble, DuPont, Microcide Pharmaceuticals, Industrial Research, Ltd. R&D collaboration: National Cancer Institute, NY State Department of Health, California Polytechnic State University, University of Puerto Rico Institute of Neurobiology.

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Technological expertise: F, Q, SMC, AF, HTDS

Fax: (512) 651-0201

Main products/instrumentation under R&D: Antibacterial and antifungal compounds — preclinical stage; Industrial enzymes, plant gene technology, under development; antiviral peptide, antiviral agents, terminal markets, dual markers.

Web site: www.ambion.com

Sealed and granted patents: N-terminal and Cterminal markers in nascent proteins. 7,101,662, U.S.; N-terminal and C-terminal markers in nascent proteins, 6,303,337, U.S.; Dual markers. 6,596,481, U.S.; other patents pending.

115 AMBI, INC. Add: 4 Manhattanville Rd. Purchase, NY 10577 Tel: (914) 701-4500 Fax: (914) 696-0860 Web site: www.ambiinc.com President/CEO: Fredric D. Price Research director: Jan de la Harpe, Ph.D. R&D expertise: Research, development and manufacture of pharmaceuticals and dietary supplements. Joint ventures: Nippon Shoji Kaisha (Japan). Technological expertise: F, P/S, RD Principal products/instrumentation: Dietary Supplement Cardia Salt Alternative, Chromax Chromium Picolinate, food processing technologies. Sealed and granted patents: 110 patents issued worldwide.

116 AMBION, INC. Add: 2130 Woodward St., #200 Austin, TX 78744-1832 Tel: (800) 888-8804

E-mail: [email protected] President: Bruce W. Leander Research director: Matt Winkler, Ph.D. R&D expertise: Research of biotechnology medicines; drug compound detection and production; quantification and purification of RNA. R&D collaboration: Cenetron Diagnostics — development of armored RNA. Technological expertise: Q, RD, GA, CH/S, AB, SY Principal products/instrumentation: RPA II, HybSpeed and DirectProtect, Ribonuclease protection assays for the sensitive detection of RNA; BrightStar BioDetect, Non Isotopic detection of RNA and DNA probes; mMESSAGE mMACHINE, MAXJscript, MEGAscript, Ultra high yield transcription kits for the production of mass quantities of RNA or for producing High specific activity RNA probes; DEGAprime for random priming of DNA; MisMatch Detect II, A non isotopic method for the detection of single base mismatches in DNA; NortherruMax, Complete Northern analysis kit for low background Northern Blotting; QuantutumRNA, RETROscript, RNA quantitation and analysis using RT-PCR; StripEZ System for stripable probe synthesis and removal. Main products/instrumentation under R&D: Ribonuclease resistant RNA, reagents for inactivating ribonucleases, in vitro RNA transcription methods, R&D, 2008. Sealed and granted patents: AMBION holds numerous patents related to Transcription and RNA Detection and Quantification (2001); Compositions and methods of using a synthetic Dnase I. 7,067,298, U.S.; Ribonuclease resistant RNA preparation and utilization. 7,033,749, U.S.; Methods and reagents for inactivating ribonucleases. 6,825,340, U.S.;

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Methods and reagents for inactivating ribonucleases RNase A, RNase I and RNase T1. 6,777,210, U.S.; Compositions and methods for increasing the yields of the in vitro RNA transcription and other polynucleotide synthetic reactions. 6,586,219, U.S.; Compositions and methods for increasing the yields of the in vitro RNA transcription and other polynucleotide synthetic reactions. 6,586,218, U.S. (2002–2008); other pending.

117 AMCELL CORP. Add: 1849 Bayshore Highway Ste. 300 Burlingame, CA 94010 Tel: (650) 227-1100

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President/CEO: That T. Ngo, Ph.D. Research director: That T. Ngo, Ph.D. R&D expertise: Biotechnology product development, biomedical diagnostic kits to underserved international markets. Joint ventures: ICD, LLC. Technological expertise: PA, H/CF, DR Principal products/instrumentation: DR70 1997, PyloriProbe 1997, various disease medical diagnostic kits in areas of cancer; infectious diseases; allergy; endocrinology; diabetology; nephrology; drugs of abuse. Main products/instrumentation under R&D: Preclinical OncoChek, disease medical diagnostic kits. Sealed and granted patents: DR-70.

Fax: (650) 227-1111 E-mail: [email protected] Web site: www.amcell.com President: Stefan Miltenyi

119 AMERICAN ALLIED BIOCHEMICAL, INC.

Research director: Richard W. Reeves

Add: 14160 E. Evans Ave. Aurora, CO 80014

R&D expertise: Development of cell/tissue culture and cell therapy.

Tel: (800) 873-3018

R&D collaboration: Miltenyi Biotec GmbH.

E-mail: [email protected]

Key sales market contracts: Kirin.

Web site: www.aablabs.com

Technological expertise: TE, C/TC, GT, H/CF

President: Mark Fagan, Ph.D.

Principal products/instrumentation: Clinimacs Cell Seperation system, cell/tissue culture products.

Research director: Jennifer Blakeley

Subsidiary bodies: Amcell GmbH, Germany.

118 AMDL, INC. Add: 2492 Walnut Ave., Ste. 100 Tustin, CA 92780-6953 Tel: (714) 505-4460 Fax: (714) 505-4464

Fax: (303) 755-7135

R&D expertise: Enzymetic technique development, restriction enzymes production. Technological expertise: E, ET, DK Principal products/instrumentation: Restriction enzymes, transferring enzymes, induced enzymes, allosteric enzymes, lambda DNA, agarose, lamba DNA markers.

120 AMERICAN BIOANALYTICAL, INC.

E-mail: [email protected]

Add: 15 Erie Dr. Natick, MA 01760

Web site: www.amdl.com

Tel: (800) 443-0600

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Fax: (508) 655-2754 E-mail: [email protected] Web site: www.americanbio.com President: Vincent P. Cooney Research director: Eric Rosenvold R&D expertise: Development and manufacture of chemicals for life sciences.

neurodegenerative diseases, coronary artery diseases, cancer, preclinical. Subsidiary bodies: San Antonio, TX; Notre Dame, IN; Ireland. Sealed and granted patents: Methods for treating a tumor containing fibrin using a fibrin specific monoclonal antibody and compositions use therein, 6,294,173, U.S.

Technological expertise: Q, P/S Principal products/instrumentation: Phenols, acryl amides dextran sulphate, formamide di.

121 AMERICAN BIOGENETIC SCIENCES, INC. Add: 1375 Akron St. Copiague, NY 11726 Tel: (516) 789-2600; 1-646-2029679 Fax: (516) 789-1661 E-mail: [email protected] Web site: www.mabxa.com President: John S. North Research director: George Christoffersen R&D expertise: Biotechnology medicine product development, focus on cardiovascular and neurobiology products, vaccines. R&D collaboration: University of Notre Dame, Trinity College. Key sales market contracts: Yamanouchi. Key license and trade contracts: Yamanouchi, Medeva. Technological expertise: RD, GA, HTDS, C/TC, DD, GT Principal products/instrumentation: CadKit, 1991; MH-1. Main products/instrumentation under R&D: Alzheimer’s diagnostic reagents, MH 1 imaging, fibrin specific monoclonal antibodies, monoclonal antibodies, Hepatitis A Vaccine; MH1-Fab imaging agent for the detection of cardiovascular thrombosis Phase II, 2008; therapeutic drugs of epilepsy, migraine and mania,

122 AMERICAN DIAGNOSTICA, INC. Add: 222 Railroad Ave. P.O. Box 1165 Greenwich, CT 06836 Tel: (203) 661-0000 Fax: (203) 661-7784 E-mail: [email protected] Web site: www.americandiagnostica.com President/CEO: Richard Hart, Ph.D. MB Research director: J. Bognacki, Ph.D. R&D expertise: Research, design and development of in vitro diagnostics for cancer, cardiovascular disease, coagulation disorders, thrombolytic disorders, and drug discovery methods. Technological expertise: PA, SMC, C/TC, D-D, RD, HTDS Principal products/instrumentation: DVV test and DVV confirm reagents for Lupus Anticoagulant testing; IMUBIND uPA, IMUBIND uPAR, and IMUBIND Tissue PAII ELISA Kits for cancer prognosis; ACTICHROME enzymatic assay kits, diagnostic reagent for coagulation disorders.

123 AMERICAN FLUOROSEAL CORP. Add: 431-D East Diamond Gaithersburg, MD 20877 Tel: (301) 990-1407 Fax: (301) 990-1472

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E-mail: [email protected] Web site: www.teflonbag.com

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125 AMERICAN INTERNATIONAL CHEMICAL, INC.

President: Herb Cullis R&D expertise: Development of cell culture, teflon bags, custom media, cryopreservation systems.

Add: 17 Strathmore Rd. Natick, MA 01760

Technological expertise: BA, C/TC, GA, HTDS, PA, TE

E-mail: [email protected]

Principal products/instrumentation: Vue Life (teflon culture systems), Kryo Vue (kapton cryopreservation system), cryoprotector. Sealed and granted patents: Laser welded teflon.

Tel: (508) 655-5805; (800) 238-0001 Fax: (508) 655-0927 Web site: www.aicma.com R&D expertise: Development of bulk specialty chemicals to biotech/diagnostic industries; purification reagents, custom synthesis, DNA/RNA synthesis reagents, and other biotechnology medicines. Technological expertise: Q, P/S, AB, GA, GT, G, PIS

124 AMERICAN HOME PRODUCTS CORP. Add: 5 Giralda Farms Madison, NJ 07940 Tel: (201) 660-5000 Fax: (201) 660-5771 President/CEO: John R. Stafford R&D expertise: Pursue new biotechnology chemical drug products through internal R&D. R&D collaboration: Proteus Internationalanimal health products; Genetics Inst. new small molecule drugs and rhIL-ll; Affymax NV — drug discovery in therapeutic areas. ALZA Corp. — the pharmaceutical products; Lederle Labs — Verelan for Hypertension. Key license and trade contracts: U.S. Bioscience — Hexalen oral treatment for ovarian cancer. Principal products/instrumentation: Venlafaxine antidepressant, rhIL-II Orudis sustainedrelease dosage form. Main products/instrumentation under R&D: New small molecule drugs. Subsidiary bodies: Pharmaceutical research facilities: Radnor, PA; Princeton and Hammonton, NJ.

Main products/instrumentation under R&D: Diagnostics, Human Genome Project, Nutraceuticals. Specialty chemicals, Chemical raw materials such as Guanidine Hydrochloride, Urea, Detergents, DNA/RNA synthesis reagents, other USP/ACS/Reagent grade chemicals for large scale processes and custom sourcing, vaccines, enzymes, DNA purification reagents.

126 AMERICAN PEPTIDE COMPANY, INC. Add: 777 E. Evelyn Ave. Sunnyvale, CA 94086 Tel: (408) 733-7604 Fax: (408) 733-7603 E-mail: [email protected] Web site: www.americanpeptide.com President: T. Nakamura, Ph.D. Research director: Shawn Lee, Ph.D. R&D expertise: Peptide biotechnology medicines, peptide instrumentation, building block. R&D collaboration: Central Research Institute, Japan.

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Technological expertise: PA, P/S, SMC, CC, SY, PIS, COC, CS, ET, PS, GP

Tel: (314 ) 991-4545; (800) 331-6661

Principal products/instrumentation: Beta Amyloids, Orexin, Cart peptide, Neuropeptides, Endothelins, Conotoxins, Neuropeptide Y, BQ 788, Adrenomedollins, ICE Inhibitors of other peptides used in apoptosis field, orexins, pharmaceutical grade peptide, recombination insulin, APC-GmPI instrument.

E-mail: [email protected]

Main products/instrumentation under R&D: Development Salmon Calicitonin, Leuprolide, Busereline & other LHRH analogs under GMP, HIV peptides.

Technological expertise: CC, E, PIS, P/S, SMC, SY

127 AMERICAN QUALEX Add: 920-A Calle Negocio San Clemente, CA 92673

Fax: (314) 991-4692; (800) 999-9925 Web site: www.arc-inc.com President/CEO: Surendra Gupta, Ph.D. Research director: Surendra Gupta, Ph.D. R&D expertise: Development and manufacture of radio labeled chemicals for biomedical research.

Main products/instrumentation under R&D: High quality radiochemical over 1100 (many exclusive) radio labeled (14C, 3H, 32P, 125I) amino acids, autoradiography standards, biological chemicals, carbohydrates, various drugs, fatty acids, isoprenoids, lipids, nucleotides, reagents, steroids, etc.

Tel: (949) 492-8298 Fax: (949) 492-6790 E-mail: [email protected] Web site: www.americanqualex.com

129 AMERICAN TYPE CULTURE COLLECTION

President: Dan Moothart

Add: 10801 University Blvd. Manassas, VA 20110-2209

Research director: Laurie Stephen

Tel: (703) 365-2700; (800) 638-6597

R&D expertise: Research of immunology, peptide synthesis and biochemicals synthesis; immunochemicals manufacturing.

Fax: (703) 365-2701

Technological expertise: PA, P/S, PIS, H/CF, C/TC Principal products/instrumentation: Peptides, primary antibodies, secondary antibodies. Main products/instrumentation under R&D: Epitope tag, antibodies to cardiac markers, in development, monitor peptides.

E-mail: sales@atcc. org Web site: www. atcc. org President/CEO: Raymond H. Cypress, DVM, Ph.D. Research director: Jay George, Ph.D. R&D expertise: R&D and manufacture of cell and tissue culture, related biotechnology products, contract research services. Technological expertise: C/TC, CW, H/CF, LC/TC

128 AMERICAN RADIOLABELED CHEMICALS, INC. Add: 11624 Bowling Green Dr. St. Louis, MO 63146

Principal products/instrumentation: Cell lines, hybridomas, feeder cells, hybridoma culture medium, bacteria, DNA molecular weight markers, PCR mycoplasma detection kit, viruses, fungi, huma cDNA clones, vectors,

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libraries; Mycoplasma testing, DNA fingerprinting, microorganism ID, cell banking. Main products/instrumentation under R&D: Cell and tissue culture, biotech drugs, biotechware.

130 AMERSHAM PHARMACIA BIOTECH Add: Bjorkgatan 30 Uppsala SE-75184 Sweden Tel: (46) 18-612-0000 Fax: (46) 18-612-1200 E-mail: [email protected] Web site: www.apbiotech.com President: Andrew Carr Research director: Mike Hayes R&D expertise: Develop biotechnology medicines and peptide instrumentation providing the advanced technologies to discover, develop and deliver therapies faster and more costeffectively then ever before. Its innovative systems used to sequence genes; uncover the structure and function of genes and proteins, separate biomolecular, screen potential drugs and manufacture biopharmaceuticals. Technological expertise: BI, BA, R, Q, CB, COC, CH/S, GA, G, HTDS, SMC, E, PIS, PG, PA, PMC, P/S, RD, SY, C/TC, H/CF Principal products/instrumentation: Biologicals, specialty chemicals, enzymes, single cell proteins, vaccines, monoclonal antibodies, SMART System, peptide columns, RESOURCE RPC column, FPLC, AKTA Purifier, Source chromatography media, Streamline columns and media, BioProcess media for industrial chromatography, Chromaflow and Fineline columns, AKTA design chromatography systems. MegaBACE automated high throughput DNA sequencer, Thermo Sequenase and DYEnamic ET terminators for DNA

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sequencing, LEADseeker homogenous imaging system for high throughput screening, SPA drug screening assays, Cytostar-T assays, receptor ligands, 14C, 3H, and 125I radiochemicals, OligoPilot and OligoProcess DNA/RNA synthesizers, amidites, Cytodex, Cytopore and Cytoline microcarriers, Fast Trak validation. Subsidiary bodies: NORTH AMERICA: Amersham Pharmacia Biotech, Inc., 800 Centennial Ave, P.O. Box 1327, Piscataway, NJ 08855-1327, USA, Tel: (800) 526-3593, Fax: (800) Fax-3593; EUROPE: Amersham Pharmacia Biotech Europe GmbH, Munzinger Strasse 9, D-79111, Freiburg, Germany, Tel: (49) 761-45190, Fax: (49) 761-4519-159 (Postfach 5480, D-79021 Freiburg, Germany); JAPAN: Amersham Pharmacia Biotech KK, Otsuka Daiichi Seimei Bldg., 32-22, Higashi Ikebukuro 2-chome, Toshimaku, Tokyo 170, Japan, Tel: (81) 3-5331-9317, Fax: (81) 3-5331-9372; OTHER COUNTRIES: International Trading Division-Amersham Pharmacia Biotech Ltd., Amersham Place, Little Chalfont, Buckinghamshire, England HP79NA, Tel: (44) 1494-544100, Fax: (44) 1494-544350.

131 AMERSHAM PHARMACIA BIOTECH Add: 800 Centennial Avenue Piscataway, NJ 08855 Tel: (800) 526-3593 Fax: (877) 295-8102 E-mail: [email protected] Web site: www.apbiotech.com President: Jack Ball Research director: John Burczak Subsidiary of Nycomed Amersham R&D expertise: The technologies to discover, develop and deliver therapies faster and more cost-effectively then ever before. Innovative

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systems used to sequence genes, uncover the structure and function of genes and proteins, separate biomolecules, screen potential drugs and manufacture biopharmaceuticals. Technological expertise: BI, BA, S, C/TC, COC, CH/S, E, GA, G, HTDS, PG, PA, PMC, P/S, RD, Q, SMC, SY Principal products/instrumentation: ALFwin Fragment Analyser, HLA Sequityper, HLA RSCA typer, Source chromatography media, Streamline columns and media, BioProcess media for industrial chromatography, Chromoflow and FineLine columns, AKTA design chromatography systems. MegaBACE automated high throughput DNA sequencer, Thermo Sequenase and DYEnamic ET terminators for DNA sequencing. LEADseeker homogenous imaging system for high throughput screening, SPA drug screening assays, Cytostar-T assays, receptor ligands, 14C, 3H, and 125I radiochemicals, OligoPilot and Oligo-Process DNA/RNA synthesizers, amidites, Cytodex, cytopore and Cytoline microcarriers. Fast Trak validation. Subsidiary bodies: REGIONAL OFFICES: NORTH AMERICA — Amersham Pharmacia Biotech, Inc., 800 Centennial Ave., P.O. Box 1327, Piscataway, NJ 08855-1327, USA, Tel: (800) 526-3593, Fax: (877) 295-8102; EUROPE — Amersham Pharmacia Biotech Europe GmbH, Munzinger Strasse 9, D-79111, Freiburg, Germany, Tel: (49) 76145190, Fax: (49) 761-451-9159 (Postal Address: Postfach 5480, D-79021 Freiburg, Germany); JAPAN — Amersham Pharmacia Biotech KK, Otsuka Daiichi Seimei Bldg, 3222, Higashi Ikebukuro 2-chome, Toshima-ku, Tokyo 170, Japan, Tel: (81) 3-5331-9317, Fax: (81) 3-5331-9372; OTHER COUNTRIES — International Trading Division, Amersham Pharma-cia Biotech Ltd., Amersham Place, Little Chalfont, Buckinghamshire, England HP7 9NA, Tel: (44) 1494-544100, Fax: (44) 1494-544350.

132 AMGEN, INC. Add: 1 Amgen Center Dr. Thousand Oaks, CA 91320-1790 Tel: (805) 447-1000, 447-5631 Fax: (805) 447-1010 Web site: www.amgen.bio.com President: Kevin W. Sharer R&D expertise: Discover, design, develop, manufacture and market human chemical therapeutics, biotechnology medicines and vaccines based on advanced cellular and molecular biology. Joint ventures: Kirin Brewery, Epogen and Neupogen, MGDF (megakaryocytic growth and development factor). R&D collaboration: Regeneron, with a focus on brain derived neurotrophic factor, neurotrophic-3; Alanex, small molecule therapeutics that act through peptide receptors; Amcell, cell separation and cell characterization technology; Arris, cytokine mimetics; Medtronic, brain derived growth factor delivery systems; MIT, research collaboration; Sugen, receptor tyro sine kinases and receptor tyrosine phosphates; The Rockefeller University. Key sales market contracts: Hoffmann-La Roche, Neupogen. Key license and trade contracts: Johnson and Johnson, Epogen. Technological expertise: RD, F, D, COC, H/CF, C/TC, M, SY, Q, AB, DD, T, GT Principal products/instrumentation: EPOGEN, recombinant human erythropoeitin (Epoetin alfa), rEPO 1989; NEUPQGEN, recombinant human granulocyte colony stimulating factor (Filgrastim), 1991; Infergen (interferon alfacon) for treatment of chronic viral hepatitis C, 1997; Panitumumab Bectibix for treatment of EGFR-expressing metastatic colorectal carcinoma, 2006; Cinacalcet hydrochloride sensipar secondary hyperparathro idism in patients with chronic kidney disease, 2004; palifermi

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kepivance, 2004; met-stem cell factor (stemgen), mobilizes the PBPC, 2000. Enlrel treat arthritis, 2004; Meulaste, 2005; panitumumab (Vectibix) treat rectocolonic carcinoma, 2007; stemgen ancestim, PBPC transplantation. Main products/instrumentation under R&D: Stem cell factor, consensus interferon, neurotrophic factors, Abarelin, prostate cancer Phase III/II; palifermin (Repivance), Phase III, 2008 phase; hepatitis B vaccine, interleukin-2, additional indications for NEU-POGEN, megakaryocyte growth and development factor (HGDF), brain-derived neurotrophic factor (BDNF), Denosumab (AMG 162), III, 2008; AMG 531, Phase III, 2008; Soluble tumornecrosis factor-a Reratinocyte growth factor (RGF), Phase III; Neuroimmunophilins for Parkinson’s syndrome, Phase II; Calcimimetics (oral hyperpara-thyroid hormone blocking agent), Phase II/ III, receptor type (STNF-R1), RA, Phase III, abavelix, cancer, Phase III, calcimimetics, Phase II; Vectibix (panitumumab) treatment in Phase III PACCE (Panitumumab Advanced Colorectal Cancer Evaluation) study, 2007. Subsidiary bodies: Boulder, CO; Brussels, Belgium; Paris, France; Munich, Germany; Milan, Italy; Breda, The Netherlands; Barcelona, Spain; Lucerne, Switzerland; Cambridge, U.K.; Ontario, Canada; Hong Kong, China; Louisville, KY; Sydney and Melbourne, Australia; Juncos, Puerto Rico; Tokyo, Japan; Lisbon, Portugal; Vienna, Austria; Bromma, Sweden. Sealed and granted patents: Nucleic acids encoding TNF inhibitor. 6,541,620, U.S.; tmst2, a novel member of the TNF-receptor supergene family. 6,627,199, U.S.; Nucleic acids encoding MK 61 receptors. 7,153,669, U.S.; host cells for producing human monoclonal antibodies to CTLA-4. 7,132,281, U.S.; gene expression, 7,105,313, U.S.; Specific binding agents of human angiopoietin-2, 7,138,370, U.S.; Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases, 7,033,776, U.S.; Truncated soluble tumor necrosis factor type-1 and type-II receptors,

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6,989,147, U.S.; Method for controlling metallophosphate precipitation in high cell density fermentation. 7,118,884, U.S.; N-terminally chemically modified protein compositions and methods. 7,090,835, 6,956,027 U.S.; Fully human antibody Fab fragments with human interferon-gamma neutralizing activity. 7,084,257, U.S.; Method of stimulating growth of melanocyte cells by administering stem cell factor. 6,852,313, U.S.; Chemical modification of proteins to improve biocompatibility and bioactivity, 6,770,746, U.S.; DKR polypeptides, 6,344,541, U.S.; Tissue specific transgene expression, 6,268,212, U.S.; Fibronolytically active polypeptide. 6,261,820, U.S.; Fibronolytically active polypeptide. 6,261,820, U.S.; Osteoprotegerin, 6,369,027, 6,284,740, 6,284,728, 6,288,032. U.S.; Stem cell factor formulations and methods, 6,288,030, U.S.; Nucleic acids encoding osteoprotegerin, 6,284,485, U.S.; Genes encoding LSIRF polypeptides, 6,369,202, U.S.; Shc-binding protein, 6,399,747, U.S.; IK K-alpha. Proteins, nucleic acids and methods. 7,045,613, U.S.; IL-17 receptor like molecules and uses thereof, 7,094,566, U.S.; Method for increasing hematopoietic progenitor cells by stem cell factor, 6,967,029, U.S.; Inhibition of retrovirus infection, 6,869,925, U.S.; Peptides and related molecules that modulate nerve growth factor activity, 6,919,426, U.S.; Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors, 6,858,409, U.S.; Stem cell factor compositions, 6,841,147, U.S.; fhm, a novel member of the TNF ligand supergene family. 6,852,839, U.S.; Keratinocyte growth factor-2 products, 6,743,422, U.S.; Glial cell line-derived neurotrophic factor, 6,362,319, U.S.; Human collagenase inhibitor, recombinant vector system for using the same and recombinant-DNA method for manufacturing the same, 6,342,374, U.S.; Microbiological desulfurization of sulfur containing gases, 6,287,873, U.S.; G-CSF hybrid molecules and pharmaceutical compositions, 6,261,550, U.S.; TNF Receptors, TNF Binding Proteins And DNAs Coding For

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Them, 6,271,346, U.S.; Methods for activating an erythropoietin receptor using antibodies, 6,319,499, U.S.; Combination therapy using a TNF binding protein for treating TNF-mediated diseases, 6,306,820, U.S.; Method for preventing and treating hearing loss using a neurturin protein product, 6,274,554, 6,274,554, U.S.; Composition and method for treating inflammatory diseases, 6,294,170, U.S.; TNF receptors, TNF binding proteins and DNAs coding for them, 6,294,352, U.S.; Pharmaceutical compositions of fibrinolytic agent, 6,440,414, U.S.; Method of ameliorating the harmaful effects of TNF using a polypeptide having the ability to bind to TNF, 6,417,158, U.S.; Chemical modification of proteins to improve biocompatibility and bioactivity, 6,420,340, U.S.; Site-directed dual peglation of proteins for improved bioactivity and biocompatibility, 6,420,339, U.S. (2008); many patents are pending.

Web site: www.ampcinc.com President/CEO: Keith Barnes Research director: Steve Welch, Vice President R&D R&D expertise: Development of functional proteins for the food, nutraceutical and biological industries. Joint ventures: Hilmar Cheese (Hilmar, California) — Whey Proteins, Lactose. Technological expertise: SMC, P/S, BA Principal products/instrumentation: Bovine Serum Albumin (BSA), Cohn Analog, 1998; Whey Protein Concentrate, AMP80, AMP800, including AMP8000, AMPRO810; Lactose, Functional Meat Proteins; Synergy, MyoGel. Main products/instrumentation under R&D: Porcine and Bovine Lipoprotein Fractions for cell culture; Transferrin; High-purity bovine immoglobulins; defibrinated bovine plasma for diagnostics, porcine islet preparation.

133 AMINO LABORATORY, LTD. Add: Science Park Kiryat Weizmann Rehovot 76326 Israel Tel: (972) 8-940-9494 Fax: (972) 8-940-8474 President: Wolf Blumenthal Research director: Dr. Yaacov Alon R&D expertise: Development of cell/tissue culture, recombinant DNA. Technological expertise: C/TC, RD Principal products/instrumentation: Diagnostic systems for plant diseases, DNA probes, plant tissue culture, recombinant DNA origin human insulin. 134 AM PC, INC. (AMERICAN PROTEIN) Add: 2325 N. Loop Drive Ames, IA 50010 Tel: (515) 296-7100 Fax: (515) 296-7110

135 AMPHOTECH, LTD. Add: 200 Cummings Center Suite 426H Beverly, MA 01915 Tel: (978) 922-8193 Fax: (978) 922-8193 E-mail: [email protected] Web site: www.amphotech.com President/CEO: Neal H. Wright Research director: Neal H. Wright R&D expertise: Contract research of analytical chemistry & synthesis; reagents; safety equipment products division; new & refurbished analytical instruments & lab equipment; relative novel products manufacture. Joint ventures: Sanitary monitoring programs with Faulkner Medical Laboratories. R&D collaboration: Proseq, Inc., Front Run Organics, Solotech, Inc. Technological expertise: CC, E, Q, BA, COC, PIS, PMC, P/S, R, SMC, SY

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Principal products/instrumentation: Heterobifunctional crosslinkers, biotinylation reagents, biological detergents, bioassay systems. Main products/instrumentation under R&D: New matrix materials for mass spectrometry, non clinical trials in R&D phase; Rapid qualitative specific bacterial pathogen detection in R&D, non-clinical trial, new/refurbished analytical instruments.

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and neurodegenerative diseases, genomics marker and gene therapy for cardiovascular diease, antiviral antibodies, antiviral protein. Sealed and granted patents: Various patents are pending.

137 AMRESCO, INC. Add: 30175 Solon Industrial Pkwy. Solon, OH 44139 Tel: (440) 349-1313; (800) 829-2802

136 AMRAD CORPORATION LIMITED

Fax: (440) 349-1182

Add: 576 Swan St. Private Bag 29 Richmond, Victoria 3121 Australia

E-mail: [email protected]

Tel: (61) (0) 3-9208-4000

President: David A. Camiener

Fax: (61) (0) 3-9208-4350

Research director: Milita Matousek, Ph.D.

Web site: www.amrad.com.au

R&D expertise: Specializing in biotech medicines custom research; A variety of agarose, acrylamides and precast gels for electrophoresis; Various salt forms, buffers, chaotic agents, chelating agents, detergents, enzymes, enzyme substrates and molecular biology applications research.

President: John P. Grace Research director: John Flack R&D expertise: Commercialization production of Australian biomedical pharmaceutical research; biopharmaceutical research & development, manufacture. Joint ventures: AMRAD Pharmaceuticals — 55% AMRAD, 45% Merck, Sharp & Dohme, Aventis, DevCo and Serono. R&D collaboration: Chugai, Aventis, DevCo and Serono. Key sales market contracts: Co-marketing in Australia with Merck; License from Chugai to market Granocyte (G-CSF) in Australia and New Zealand. Key license and trade contracts: Serono, Aventis, Edwards LifeSciences, DevCo.

Web site: www.amresco-inc.com

Technological expertise: E, PA, P/S, RD, Q Principal products/instrumentation: Antibiotics, sterile antibiotic mixtures, solubilized amphoterecin B, buffers, enzyme immobilization, enzyme substrate complex. Sealed and granted patents: 5,429,797; 5,439,667; 5,290,706; 5,344,637; 5,622,696; 5,482,676, and 5,700,365.

138 AMS BIOTECHNOLOGY (EUROPE), LTD.

Technological expertise: G, GT, PG Principal products/instrumentation: Lipec, Prinivil, Granocyte, Amprace, Amfamox. Main products/instrumentation under R&D: Antivirals, neruologicals, anti-HIV drugs, HBV drugs, treatment drugs for neuromuscular

Add: 185 A&B Milton Park Abingdon, Oxon OX14 4SR UK Tel: (44) 01235-82-8200 Fax: (44) 01235-82-0482 E-mail: [email protected]

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Web site: www.immunok.com Add: Centro Nord Sub Stabile 2 Entrata E Bioggio, Ticino 6934 Switzerland

Main products/instrumentation under R&D: HIV-kits, preclinical; kits for virology, research viread, viricide.

Tel: (41) 91-604-5522 Fax: (41) 91-605-1785

140 AMYLIN PHARMACEUTICALS, INC.

E-mail: [email protected] Web site: www.immunok.com President: Nick Harding Research director: Paolo Piazza R&D expertise: Cell and tissue culture, commercialization of products for life science. Key sales market contracts: Ambion, Immunokontact, Biodesign, Serva. Technological expertise: BA, CB, GA, G, HTDS, H/CF, F, PA, RD, C/TC Principal products/instrumentation: Complete system for CHO pression, serum- and protein-free CHO system, cytokines, trace DNA detection kits, protein-free media for CHO and baculovirus and E. coli expression systems, monoclonals, peptides and recombinant protein, custom molecular biology research services.

139 AMSTERDAM SUPPORT DIAGNOSTICS B.V. Add: Bernadottelaan 15 P.O. Box 8323 Utrecht 3503 RH Netherlands Tel: (31) 30-2938-027 Fax: (31) 30-2941-526 President: Dr. W. J. van Oort Research director: Dr. J. Goudsmit R&D expertise: Research, design and development of new viral diagnostics, HIVneutralizing antibodies, viral therapeutics. Joint ventures: Academic Hospital of the University of Amsterdam. Technological expertise: Q, E, P/S, H/CF, C/TC, D-D, BI, RD

Add: 9373 Towne Centre Dr. San Diego, CA 92121 Tel: (858) 552-2200 Fax: (858) 552-2212 Web site: www.amylin.com President: Timothy J. Rink R&D expertise: Discover, develop and manufacture novel therapeutics for diabetes and other metabolic disorders. R&D collaboration: Lifescan/Johnson & Johnson. Technological expertise: RD, F, P, BA, GA, C/TC, CH/S, SY, Q, E, D-D Principal products/instrumentation: Pramlintide (Acetate), Type I and II diabetes, 2005; Exenatide (Byetta) glycemic control in patients with type II diabetes mellitus,2005; Main products/instrumentation under R&D: Pramlintide (AC137) for type I diabetes, Phase FIB; Pramlintide (AC137) for insulin-using type II diabetes, Phase III; AC625 and AC253 for syndrome X, Phase I; AC 2993 treat improved glucose control in type z diabetes, Phase II completed, 2008; Symlyn prarnlintide acetate for type Iand II diabetes, Phase III/IV, 2008; Phase III trial of pramlintide for the treatment of obesity, 2008; a global Phase III study of PEGylated interferon beta-1a in patients with relapsing multiple sclerosis, 2009. Sealed and granted patents: Use of exendins and agonists thereof for lowering plasma lipis.7,138,375, U.S.; Methods for glucagon suppression using modified exendins. 7,153,825, U.S. Inotropic and diuretic effects of exendin and GLP-1. 6,703,359, U.S.; Exendin agonist formulations and methods of administration thereof. 6,902,744, U.S.; Formulations

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for amylin agonist peptides. 6,410,744, U.S.; polypeptide and protein derivatives and process for their preparation. 7,129,327, U.S.; Methods for recombinatorial nucleic acid synthesis. 6,994,963, U.S.; Mixed amylin activity compounds. 6,936,584, U.S.; Modified exendins and exendin agonists. 6,924,264, U.S.; Methods for glucagon suppression. 6,872,700, U.S.; Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue. 6,982,248, U.S.; Exendins, exendin agonists, and methods for their use. 7,115,569, U.S.; Polymer-modified synthetic proteins. 7,118,737, U.S.; Human appetite control by glucagon-like peptide receptor binding compounds. 6,998,387, U.S.; Exendins, exendin agonists, and methods for their use. 6,989,366, U.S.(2008); other patents pending.

141 ANA-GEN TECHNOLOGIES, INC. Add: 4015 Fabian Way Palo Alto, CA 94303 Tel: (650) 494-3894 Fax: (650) 494-3893 E-mail: [email protected] Web site: www.ana-gen.com President: Saeed Races R&D expertise: Research and development of contract molecular biology and mutation detection; related novel products manufacturing. Technological expertise: Q, T, BS, C/TC, GT, G, P/S, RD, R Principal products/instrumentation: Spontaneous/induced mutation Detection; Gene Synthesis; DNA Purification, genetically engineering antibodies.

142 ANALTECH, INC. Add: 75 Blue Hen Drive Newark, DE 19713 Tel: 800-441-7540; (302)-737-6960

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Fax: (302) 737-7115 E-mail: [email protected] Web site: www.analtech.com Research director: Ed Dugan R&D expertise: Research and development of thin-layer chromatography and other biomedical instrumentation. Technological expertise: AMS, BC, PI, PMC Principal products/instrumentation: UNISCAN Video Densitometer, thin-layer chromatogram scanner, thin-layer chromatography scanner, UNIPLATES, SPICE, UNIBOND, Cyolograph Centrifugal Chromatography System, TLC AutoSpotter, thin-layer gel filtration.

143 ANALYTICAL BIOLOGICAL SERVICES Add: Cornell Business Park — 701-4 Wilmington, DE 19801 Tel: (302) 654-4492 Fax: (302) 654-8046 E-mail: [email protected] Web site: www.ABSbioreagents.com President/CEO: Charles F. Sailer, Ph.D. Research director: Brenda S. Robertson. MSc. R&D expertise: Development of custom bioreagents for drug discovery and basic applied research. Joint ventures: Biosomes, Inc. Technological expertise: PA, E, D-D, AB, BI, DD, BA, G, COC, HTDS, PIS, CH/S Principal products/instrumentation: Pharmaceuticals, contract research/clinical trials products, bioreagents for drug discovery, purified enzymes, nucleic acid extracts. Subsidiary bodies: Analytical Biological Services Inc. (ABS) provides custom bioreagents and high capacity cell culture services to drug discovery and biomedical research laboratories

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throughout the world, pharmaceutical companies in the US and Europe.

144 ANALYTICHEM CORPORATION Add: 12220 Maycheck Lane Bowie, MD 20715

Technological expertise: F, SMC, P/S, COC Principal products/instrumentation: Separation systems for drug development: Sepbox, 1997; Semisynthetic natural product: KombiNaturik; Natural Product Libraries: Megabolite; automated chromagraphy systems.

Fax: (301) 352-4077

Main products/instrumentation under R&D: Antrvirals, anticancer compounds, drug separation technologies (Sepbox, Multi-ParallelHPLC), preclinical.

E-mail: [email protected]

Sealed and granted patents: Sepbox.

Tel: (301) 352-4075

Web site: www.a-chem.com President: Nancy M. Tutini

146 ANASPEC, INC.

R&D expertise: Development and manufacture of laboratory biomedical equipment and systems for drug research use.

Add: 2149 OToole Ave. Suite F San Jose, CA 95131

Technological expertise: CPHC, SI, AMC

Tel: (408) 452-5055

Principal products/instrumentation: MSR7000 Spectroradiometer; AOTF-Based Portable Nir System, Wave runner; Southern Soxhlet Extraction System; Sampling devices, Sample preparation devices, Southern Soxhlet apparatus.

Fax: (408) 452-5059 E-mail: [email protected] Web site: www.anaspec.com R&D expertise: Development of antibodies, peptides and other biotechnology medicines. Technological expertise: PA, P/S, SY, PIS, CH/S

145 ANALYTICON AG Add: Tegeler Weg 33 Berlin 10589 Germany Tel: (49) 30-346-07-500 Fax: (49) 30-346-07-600

Principal products/instrumentation: Custom peptide synthesis, amino acids, resins & reagents for the synthesis of peptides, anticardiolipin antibodies, anti-DNA antibodies, vasoactive intestinal peptides, peptide hormone, mass spectrometry services, custom antibody products, lab software.

E-mail: [email protected] Web site: www.analyticon-ag.com President/CEO: Dr. Lutz Muller-Kuhrt

147 ANASYSCON INSTRUMENTELLE ANALYSENTECHNIK GMBH

Research director: Dr. Kai Bindseil R&D expertise: Development and manufacture of automated chromography systems; drug development based on natural products, contract research, pharmaceutical development services; compound libraries. Joint ventures: Oxford Natural Products. R&D collaboration: Merz.

Add: Vahrenwalder Str. 7 Hanover D-30165 Germany Tel: (49) 511-9357-200 Fax: (49) 511-9357-100 Web site: www.genios.de/r ubrowsing/an/ anasvscon instrumentelle analysentechnik gmbh.html

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President/CEO: Dr. H.R. Howind

Web site: www.anatel.com

Research director: Dr. W. Schaefer

President/CEO: J. Yamamori

R&D expertise: Development, design, production and marketing of biosensors plus corresponding analytical hard and software for bioengineering products research.

Research director: John Stillian

Technological expertise: BA, CH/S, PMC

Technological expertise: PMC, COS, O-C

Principal products/instrumentation: Biocart enzyme cartridges, 1992; biocart/CAFCA-system for automated multichannel on-line monitoring of key components from bioprocess media; EXPERT/ACCU pump/controller-system.

Principal products/instrumentation: Total organic carbon analyzer for high purity water, model a-1000 1993; wide-range TOC analyzer for reclaim water, 1996; organic substances analysis system for drinking water.

Main products/instrumentation under R&D: Fluorometric/photometric detector units for online analysis.

Sealed and granted patents: TOC Destruct, TOC and Conductivity measurements.

Sealed and granted patents: Projective reference evaluation.

148 ANATEK-EP Add: 17 Bishop St. Portland, ME 04103 Tel: (207) 797-8445; (800)-831-4696 Fax: (207) 772-5644 E-mail: [email protected] President: Marcia Goldfarb R&D expertise: Contract research and development for: protein chemistry; two dimensional electrophoresis; Western blot; Custom western blot strips for immunoassay.

R&D expertise: Total organic carbon analysis systems research, development and manufacturing.

150 ANAWA HOLDING AG Add: Unterdorfstrasse 23 Wangen-Zurich CH8602 Switzerland Tel: 1-8330555 Fax: 1-8330575 President: H. J. Vollenweider, Ph.D. Research director: A. N. Wicki, Ph.D. R&D expertise: Biomedical laboratory research services to the pharmaceutical and biotech industries; production of diagnostics and radiolabelled chemicals and peptides.

Technological expertise: P/S, PC

Joint ventures: TuV Product Service GmbH, testing of medical devices; Tektagen, Inc., safety testing.

Principal products/instrumentation: Western blot strips for Lyme (Borrelia burgdorferi).

Key license and trade contracts: Roche, PCR license.

149 ANATEL CORP. Add: 2200 Central Ave. Boulder, CO 80301 Tel: (303) 442-5533 Fax: (303) 447-8365 E-mail: [email protected]

Technological expertise: RD, P/S, H/CF, C/TC Principal products/instrumentation: ELISA for interferon antibody detection, radiolabelled (A3H, A14C) chemicals and peptides, reagents for molecular biology, pharmaceutical grade peptides, pharmaceutical grade proteins.

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151 ANCELL CORP.

153 ANDONIAN CRYOGENICS, INC.

Add: 243 Third St. N. P.O. Box 87 Bayport, MN 55003

Add: 90 Hatch St. New Bedford, MA 02745

Tel: (651) 439-0835

Fax: (508) 990-0337

Fax: (651) 439-1940

E-mail: [email protected]

Web site: www.ancell.com

Web site: www.cryogenics.com

President/CEO: John W. Orf, Ph.D.

President: Martin D. Andonian

R&D expertise: Research, development and manufacture of biologicals with a focus on monoclonal antibodies to human leukocyte and immune regulation molecules.

Research director: Alan Taylor

Key license and trade contracts: ICRT, Un. of MN, Un. of MI, Un. of Wash, Duke Univ., Rockefeller Univ., Dartmouth Univ., Un. of Miami, Un. of Madrid, UKT-Germany, Un. of Birmingham.

Principal products/instrumentation: Cryogenic containers, variable temperature cryostats for most research applications, Cryogenic purification devices, cryogenic separation equipment.

Technological expertise: RD, P/S, H/CF, C/TC Principal products/instrumentation: Monoclonal antibodies to human immune cell molecules (mainly CD markers), 1993; ELISA reagents trademarked as CD EIA PAG, immune regulation molecules.

Tel: (508) 992-0636

R&D expertise: Development and manufacture of cryogenic equipment. Technological expertise: BME, BC

Main products/instrumentation under R&D: Cryogenic equipment for freezing biological materials and storing them at liquid nitrogen temperatures, supercryogenic refrigerator.

154 ANDOVER CORPORATION Add: 4 Commercial Dr. Salem, NH 03079 Tel: (603) 893-6888

152 ANDCARE, INC.

Fax: (603) 893-6508 E-mail: [email protected]

Add: 2810 Meridian Pkwy. Suite 152 Durham, NC 27713 Tel: (919) 544-8220

Web site: www.andcorp.com President/CEO: Richard J. Bennett

Fax: (919) 544-9808

R&D expertise: Development and production of biomedical laboratory equipment.

Web site: www.andcare.com

Technological expertise: BME, BC

President/CEO: Steven E. Wegner

Principal products/instrumentation: Optical interference filters and coatings, optical interference microscope.

Research director: Robert W. Henkens R&D expertise: Research, development and manufacturing of DNA detection devices. Technological expertise: GA, CH/S Principal products/instrumentation: LEAD CARE-1997; DNA detection devices, DNA detection kits.

155 ANDROSCORE CORP. Add: HC 69, P.O. Box 50 Alzada, MT59311 Tel: (307) 878-4494

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Fax: (307) 878-4499

Tel: (514) 281-6084

E-mail: [email protected]

Fax: (514) 896-4926

Web site: www.childselect.com

E-mail: [email protected]

President: Ronald J. Ericsson, Ph.D.

Web site: www.angiogene.com

R&D expertise: Development of medical diagnostic devices for male fertility-human and livestock.

President: Dr. Guy Leclerc

Technological expertise: BME Principal products/instrumentation: Fertility SCORE-human male fertility diagnostic device, on market in Europe, Far East, Middle East, and Canada; BullSCORE, StudSCORE, and BoarSCORE, on market in the U.S., Canada, and the UK; fertilization diagnostic devices.

156 ANDRULIS PHARMACEUTICALS CORP. Add: 2800 Shirlington Rd. Ste, 600 Arlington, VA 22206 Tel: (703) 824-3500 Fax: (703) 820-0708

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Research director: Dr. Guy Leclerc R&D expertise: Research and development of therapeutics in cardiology; products manufacturing. R&D collaboration: Institute National de la Recherche Scientifique (PNRS): coating of endovascular devices with biomaterials. Technological expertise: AB, C/TC, DD, D-D, GA, P/S, SY, GT Main products/instrumentation under R&D: Biomaterials, clinical test, pharmaceuticals, Qliglow Radiopharmaceutical compound to be used for the prevention of post-angioplasty restenosis, preclinical; Angiogenesis compounds, discovery; therapeutics for heart disease, antiarrhythmics. Sealed and granted patents: U.S. Patent 5,821,354.

E-mail: [email protected] Web site: www.andrulis.com President/CEO: Peter J. Andrulis, Jr., Ph.D.

158 ANGIOTECH PHARMACEUTICALS, INC.

Research director: Murray Drulak, Ph.D. R&D expertise: Clinical development and production of unique immunosuppressor; antiinflammatory against wide range of conditions.

Add: 6660 N.W. Marine Dr. Vancouver, BC V6T 1Z4 Canada Tel: (604) 221-7676

Technological expertise: P/S, SY, D-D, DD

Fax: (604) 221-2330

Main products/instrumentation under R&D: Small molecular anticytokine agent, Phase II; anti-cancer agents, preclinical; small molecular anticarcinogen, unique immunosuppressant.

E-mail: [email protected]

157 ANGIOGENE, INC. Add: 1560 Sherbrooke Street East Suite Y1605 Montreal, Quebec H2L 4M1 Canada

Web site: www.angiotech.com President: Donald E. Longenecker, Ph.D. Research director: Thomas Spencer R&D expertise: Research and development of biotechnology therepeutics for angiogenesis and chronic inflammatory disease; Systemic paclitaxel treatments and paclitaxel coating for medical devices.

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R&D collaboration: UBC, Mt. Sinai Hosp, NIH, UCLA, Mass. Gen. Hosp.

anti-angiogenic and anti-invasive compound, novel molecule drugs.

Key license and trade contracts: Boston Scientific Corp., Cook Inc., CE Bard; Alcon.

Sealed and granted patents: U.S. 5,942,492; U.S. 5,994,309.

Technological expertise: SMC, DD Main products/instrumentation under R&D: Stent coatings; paclitaxel for rheumatoid arthritis, MS, psoriasis & other chronic inflammatory diseases, vanadate for cancer, drug against angiogenesis. Sealed and granted patents: Co. patents: UCLA (paclitaxel & arthritis); Mt. Sinai (vanadium compounds); UBC (vanadium compounds); NIH (paclitaxel in cardio-vascular disease); Anti-angiogenic compositions and methods of use, 6,544,544, U.S.; others are pending.

159 ANGSTROM PHARMACEUTICALS, INC. Add: 6310 Nancy Ridge Drive, #105 San Diego, CA 92121 Tel: (858) 350-1760 Fax: (858) 350-1761 E-mail: [email protected] Web site: www.angstrominc.com President/CEO: Terence R. Jones, Ph.D.

160 ANIKA THERAPEUTICS Add: 235 West Common Park Woburn, MA 01801 Tel: (781) 457-9000 Fax: (781) 305-9720 E-mail: [email protected] Web site: www.anikatherapeutics.com President/CEO: J. Melville Eagle Research director: Dr. Scott Brader R&D expertise: Develop, manufacturing and commercialize therapeutic products based on hyaluronic acid. Key license and trade contracts: BristolMyers Squibb for ORTHOVISC, Bausch & Lomb surgical for AMVIC. Technological expertise: TE, P/S, S Principal products/instrumentation: AMVISCophthalmic surgery, 1993; ORTHOVISC for osteoarthritis hyaluronidase. Main products/instrumentation under R&D: INCEPT for post surgical adhesions, Phase II.

Research director: Terence R. Jones, Ph.D. R&D expertise: Research, design and development of novel small-molecule pharmaceuticals for treatment of cancer and other serious diseases, using “platform” drug-design technology. Key license and trade contracts: Radiopharmaceuticals with Diatie, Inc.

161 ANIMAL BEHAVIOUR SYSTEM Add: 5909 Breckenridge Parkway Ste. G Tampa, FL 33610 Tel: (813) 621-9447 Fax: (813) 621-0751

Technological expertise: RD, C/TC, SY, SMC, D-D, CH/S

President/CEO: John A Connell

Main products/instrumentation under R&D: uPA receptor antagonists for metastasis and angiogenesis of solid tumors preclinical development;

R&D expertise: Development and production of biopharmaceuticals for veterinary health care.

Research director: Bobby G. Edwards

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Technological expertise: BA

Key license and trade contracts: Caltag

Principal products/instrumentation: Veterinary healthcare drugs including immunostimulants, immunostimulating complex, pet maintenance, disinfectant, wound care.

Technological expertise: PA, Q, SY, PIS, P/S Principal products/instrumentation: Customized antibodies, peptide arrays, peptide hormone, peptide synthesis, peptide library, affinity purification, affinity ligand, affinityisolated antibodies.

162 ANIMAL CARE SYSTEMS, INC. Add: 1460 W-Ganal court Suite 100 Littleton, CO 80120

164 ANIMAL TECHNOLOGIES, INC.

Tel: (720) 283-0177

Add: 2016 E. Erwin Tyler, TX 75702

Fax: (720) 283-0179

Tel: (903) 592-1363

E-mail: [email protected]

Fax: (903) 593-0960

Web site: www.animalcaresystems.com President: Germain R. Rivard, DVM, Ph.D. Research director: Germain R. Rivard, DVM, Ph.D. R&D expertise: Development and manufacturing of animal caging and veterinary services. Technological expertise: T Principal products/instrumentation: Vented Mice Cage & Rack System, 1999; Barrier Unit. Main products/instrumentation under R&D: Microenvironmental Sensors, R&D. Sealed and granted patents: Animal caging and biological storage systems.

E-mail: [email protected] Web site: www.animaltechnologies.com President: George H. (Skip) Wrape, Jr. R&D expertise: Development and production of raw animal biological products. Technological expertise: TE, BA, C/TC Main products/instrumentation under R&D: Raw animal biological products, breeding improved new variety for raw animal. Subsidiary bodies: Costa Rica, Central America, South Island, New Zealand.

165 ANIMAL TECHNOLOGIES, LTD. Add: dba. B&K Universal 3403 Yale Way Fremont, CA 94538

163 ANIMAL PHARM SERVICES, INC.

Tel: (510) 490-3036 Fax: (510) 656-1921

Add: 303 Dry Creek Rd. Healdsburg, CA 95448 Tel: (800) 808-0550 Fax: (800) 808-0551

E-mail: [email protected] Web site: www.atbk.net President: Albert Nutbrown

E-mail: [email protected]

R&D expertise: Development and production of improved variety for laboratory animals.

President: Margaret Delameter

Technological expertise: T

R&D expertise: Research and development customized polycolonal antibodies.

Principal products/instrumentation: Breeding improved variety for laboratory rats and mice, breeding true animal.

Joint ventures: Caltag, IVT.

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166 ANMED/BIOSAFE, INC. Add: 7642 Standish Place Rockville, MD 20855 Tel: (301) 762-0366 Fax: (301) 762-7438 E-mail: [email protected] President: Steven H, Weisbroth, DVM. Research director: Sanford H. Feldman, DVM, Ph.D. R&D expertise: Testing research and services for cell lines, monoclonal Abs, and gene therapy products. Technological expertise: C/TC Principal products/instrumentation: Major research and services: MAP testing, cell genetics testing, complete virus panels, mycoplasma, sterility, general safety testing, contaminant analysis of cell lines and monoclonal/polyclonal antibody products in accord with “Points to Consider”, quantitative tests for DNA contamination, PCR assays; Contaminant analyses and safety testing of cell lines; monoclonal and polyclonal antibody products intended for use as in vivo diagnostics and therapeutics.

synthesize these mimetics for research, diagnostics and therapeutics. Key sales market contracts: Fisher, SOWA. Key license and trade contracts: Lynx Pharmaceuticals. Technological expertise: AB, S, CC, D-D, GA, PIS, P/S, RD, SMC, SY, Principal products/instrumentation: Special chemicals, phosphoramidites, protected nucleosides. Oligonucleotides, oligomimetics, molecular biology assays. Subsidiary bodies: Cruachem Ltd., Glasgow, UK. Sealed and granted patents: Alkyl-carboxy Amino Acid Kainate Antagonist; Dihydrophtalazine AMPA Antagonist; Arylphthalazine NMDA/AMPA Antagonist; Glutamate Pocket Modeling; Psychopharmcological Disorders; Mood Disorder; Tolerance Addiction; Cognition.

168 ANOROC SCIENTIFIC Add: P.O. Box 2001 South Hackensack, NJ 07606 Tel: (201) 891-8919 Fax: (201) 641-0789

167 ANNOVIS, INC.

President/CEO: Lou Confortini

Add: 34 Mount Pleasant Dr. Aston, PA 19014

R&D expertise: Development and production of reagents for research.

Tel: (610) 361-9224

Technological expertise: PMC, P/S, SY

Fax: (610) 361-8255

Principal products/instrumentation: Liquid scintillation chemicals: EnviroSafe, 1987; CytoSolv; Mini Solv; Organic Solv, liquid reagents for research.

E-mail: [email protected] Web site: www.annovis.com; www.cruachem. com President/CEO: Maria-Luisa Maccecchini, Ph.D.

169 ANSPEC/OHIO

Research director: Krishna Ghosh, Ph.D. R&D expertise: Novel approaches to study RNA/DNA, and to develop compounds that mimic biomolecules; Design, optimize and

Add: 12 West Selby Blvd., Suite 4 Columbus, OH 43085 Tel: (800) 521-1720

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Fax: (614) 888-7843 Web site: www.munhall_anspec.com President: Carl G. Chatfield Research director: Kelly Kiszka R&D expertise: Research and development of biotechnological equipment and supplies. Technological expertise: PIS, P/S, GA Principal products/instrumentation: Products for chromatographic separations of proteins and peptides, lab equipment for biotech drug research. Main products/instrumentation under R&D: Preparative free-flow zone electrophoresis equipment

170 ANTEK INSTRUMENTS, INC. Add: 300 Bammel Westfield Road Houston, TX 77090 Tel: (281) 580-0339 Fax: (281) 580-0719 E-mail: [email protected] Web site: www.antekhou.com President: Donald M. Wreyford CEO: Randy L. Wreyford Research director: Mark Homan, Ph.D.; Frank Yan, Ph.D. R&D expertise: Designing, developing, manufacturing, and marketing of innovative analytical instrumentation that provides real world solutions for laboratories in a wide variety of industries. R&D collaboration: Sponsoring graduate students at Texas A&M University, Chemistry Department.

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Technological expertise: COC, CH/S, D-D, HTDS Principal products/instrumentation: Pyrochemiluminescenr Total Nitrogen Analyzer (patented 1977), Pyro-fluorescent Total Sulfur Analyzer (1986), Nitrogen-Specific GC & HPLC Detectors, Sulfur Chemiluminescent GC Detector, Total Fluoride Analyzer (patent pending), Nitric Oxide Analyzer. Main products/instrumentation under R&D: Sulfur Specific HPLC detector, fluoride specific HPLC detector nitric oxide specific HPLC detector. Subsidiary bodies: Antek Instruments, GmbH, Wacholderstrasse 7, D-40489 Dusseldorf, Germany, Tel: (49) 02-03-74325; Fax (49) 02-03-741545. Sealed and granted patents: 4,018,562 (renewed 1994) — Nitrogen determination by combustion followed by chemiluminescent detection (Total Nitrogen, Nitrogen-Specific GC & HPLC Detectors); 5,152,963-Simultaneous Nitrogen (by chemiluminescent)/Sulfur (by fluorescence) determination; 4,352,779 & 4,678,756 — Sulfur determination by combustions followed by chemiluminescent detection; 5,248,616 — Nitric Oxide determination by chemiluminescence other patents are pending.

171 ANTEX BIOLOGICS, INC. Add: 300 Professional Dr. Gaithersburg, MD 20879 Tel: (301) 590-0129 Fax: (301) 590-1251 E-mail: [email protected] Web site: www.AntexBiologics.com

Key sales market contracts: Hewlett Packard Channel Partner, Agilent Channel Partner and LincQuantum.

President/CEO: V.M, Esposito, Ph.D.

Key license and trade contracts: Some of our patents are cross-licensed.

R&D expertise: Develop and market drug products to prevent and treat infectious diseases

Research director: Larry R. Ellingsworth, Ph.D.

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and related disorders; specialize in plant medicine, alternative medicine, natural medicine.

Web site: www.anthos-labtec.com

R&D collaboration: United States Department of Defense (U.S. Navy) — Campylobacter vaccine.

Research director: Ing. Christian Veleba

Key sales market contracts: SmithKline Beecham and Pasteur Merieux Serums ET Vaccines, subsidiary of Rhone Poulenc — vaccines.

Key sales market contracts: Joint marketing with Rosys AG, Switzerland under name “Rosys-Anthos”.

Key license and trade contracts: Pasteur Merieux Serums et Vaccines, subsidiary of Rhone Poulenc — Otitis media vaccine. Technological expertise: BA, S, C/TC, F, PA, RD, P/S, H/CF, DD Principal products/instrumentation: Otitis media vaccines, drugs to prevent and treat infections diseases. All products are pending. Main products/instrumentation under R&D: Campylobacter vaccine for arcuation bacillus infections, Phase III completed; Helicobacter and Haemophilus influenzae vaccines Phase I, Shigella, Moraxella, Chlamydia vaccines — preclinical, Helivax helicobacter pylori vaccine treat helicobacter pylori infection, Phase II completed, 2008. rV-MUC — treat breast cancer, Phase II; TBC CEA (vaccinia virus expressing carcinoembryonic antigen) treat colorectal cancer and lung cancer, Phase II/III, 2008. Sealed and granted patents: Numerous U.S. and foreign patents and filed applications; Moraxella catarrhalis protein, gene sequence and uses thereof 6,541,616, U.S. (2008); others pending.

172 ANTHOS LABTEC INSTRUMENTS Add: Lagerhausstrasse 507 Wals Salzburg 5071 Austria Tel: (43) 662-857-220 Fax: (43) 662-857-223 E-mail: [email protected]

President: Peter G. Fritz R&D expertise: Research, development and production of laboratory instrumentation.

Technological expertise: CH/S, R Principal products/instrumentation: Microplate luminometer, Lucyl, 1993; Microplate luminometer, Lucy2, 1997; Micro plate luminometer Lucy3, 1999; Micro plate Readers, 2001, HT, 2010; Micro plate Reader, 2020; Robotic sample processor for luminescence, Autolucy. Main products/instrumentation under R&D: Robotic sample processor for fluorescense, Autofluor, launch 2000; Microplate fluorometer, launch 2000; Microplate reader, 2000; launch 2000; microplate luminometer, Lucy 4.

173 ANTIBODIES, INC. Add: P.O. Box 1560 Davis, CA 95617-1560 Tel: (800) 824-8540 Fax: (530) 758-6307 E-mail: [email protected] Web site: www.antibodiesinc.com President/CEO: Richard L. Krogsrud, Ph.D. Research director: Richard L. Krogsrud, Ph.D. R&D expertise: Development and production of immunochemicals. Technological expertise: C/TC, H/CF, PIS, PG, PA Principal products/instrumentation: Strep A diagnostic kit, DETET-A-STREP; Giardia Lambda Diagnostic Kit, GiardEIA; Hep2 ANA Test Kit; Antin DNA Test Kit, Crithi DNA, firs-aid kits, bispecific antibodies, complete antibodies.

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as well as cosmopeutics, contract research of biopharmaceuticals.

Add: 1135 San Antonio Rd. Ste. D Palo Alto, CA 94303-4310

R&D collaboration: ONCase: Shionogi & Co. Ltd.; FIDRA Eiken Chemical Co.

Tel: (650) 938-4300

Key sales market contracts: MetaMouse: Mitsubishi Corp.; HDRA: Eiken Chemical Co.; Methioninase: Wako Pure Chemical.

Fax: (650) 938-4390 E-mail: [email protected] Web site: www.antibody.com President/CEO: John S. Kenney, Ph.D. Research director: Mototaka Senda, Ph.D. R&D expertise: Research and development of custom antibody products and services, new professional antibody research and development Key sales market contracts: Applied Bioproducts; Scandinavian Biotechnology Consulting. Key license and trade contracts: Becton Dickinson immunocytometry systems. Technological expertise: C/TC, H/CF, PA Principal products/instrumentation: Polyclonal Solutions, 1998; Monoclonal Solutions; Multiclonal.Antibody. Main products/instrumentation under R&D: EDG Receptor.Antibodies; Arninotriazole Antibodies, neutralizing antibodies. Subsidiary bodies: Antibody Solutions SARL, 74 Route du Rhin, F-67401 IUkirch, France.

175 ANTICANCER, INC. Add: 7917 Ostrow St. San Diego, CA92111 Tel: (858) 654-2555 Fax: (858) 268-4175 E-mail: [email protected] Web site: www.anticancer.com President/CEO: Robert M. Hoffman, Ph.D. Research director: Yuying Tan, M.D. R&D expertise: Research, development and marketing of cancer therapeutics and diagnostics

Key license and trade contracts: ONCase: Shionogi & Co. Ltd.; HDRA: Eiken Chemical Co. Technological expertise: BA, C/TC, DD, DD, E, F, GA, HTDS, P/S, RD, SMC, TE Principal products/instrumentation: HDRA: Drug response assay for chemotherapy individualization and drug discovery, MetaMouse: Human tumor bearing animal model for drug discovery, Homocysteine Enzymatic Assay. Main products/instrumentation under R&D: ONCase: Protein cancer therapeutic with universal indication and tumor selectivity and apoptotic activity, Phase II. Sealed and granted patents: MetaMouse I, U.S. 5,491,284; MetaMouse II U.S. 5,569,812; MetaMouse Japan 2,664,261; MetaMouse Europe 437,488; HDRA I U.S. 5,474,909; HDRA II (Prolif Viability) U.S. 5,726,009; DermaTek (Skin Histo) U.S. 5,849,579; DremaTek (Skin Histo) Europe 573,606; DermaTek (Skin Histo) Japan 2,950,519; ONCase (improved form) U.S. 5,888,506; ONCase (Combo Therapy) U.S. 5,690,929; ONCase (High Expression) U.S. 5,891,704; CARDIOase I U.S. 5,715,835; Methioninase Australia 687,768; Methioninase Japan 2,930,723; Methioninase Australia 708,361; Soda Methioninase 1 U.S. 5,861,154; Soda Methioninase 2 U.S. 5,863,788; DermaTek(Lipo Mel) U.S. 5,641,508; DermaTek (Hair Color Pigment) U.S. 5,965,157; DernaTek (Macromolecules) U.S. 5,914,126; DermaTek (Chemo Alopecia) U.S. 5,753,263; DermaTek (Liposome) Japan 2,950,520; Skin Vibration U.S. 5,803,177; Skin Vibration II US 6,080,127; HCY Assay (Gamma glut) U.S. 5,985,540; HCY Kit U.S.

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5,998,191; HCY Kit (Fluorescent) U.S. 6,066.467, (2008); Nude mouse model for human neoplastic disease. RE39, 337, U.S.; Method to provide for production of hair coloring pigments in hair follicles. 6,621,596, U.S.; Method and model for hair pigmentation. 6.372,489, U.S. (2008); other patents pending.

R&D expertise: Research and development of biopharmaceuticals for toxic diagnosis. Technological expertise: K, C, PA, TE Principal products/instrumentation: Clinical Diagnostics: Monoclonal and polyclonal finished blood grouping sera, cytohistologic differential diagnostics, botulism antitoxin.

178 ANVER BIOSCIENCE DESIGN, INC. 176 ANTIGENIX AMERICA, INC. Add: Antigenix America, P.O. Box 2666, Huntington Station, NY 11746

Add: 160 East Montecito Ave. Sierra Madre, CA 91024 Tel: (626) 355-1568

Tel: (516) 485-1008, (631) 424-0296

President: Anthony J. Verbiscar, Ph.D.

Fax: (516) 485-1009

R&D expertise: Research, development and production of plant-derived products.

E-mail: [email protected] Web site: www.antigenix.com President: M. Dempsey R&D expertise: Research and development of monoclonal antibodies and related biochemicals for immunology research; contract antibody development. Technological expertise: H/CF, PA Principal products/instrumentation: Monoclonal antibodies for transforming growth factor beta, G-CSF receptor, CD6 receptor, MCP-3 receptor. Main products/instrumentation under R&D: MIP- 1 Alpha antibodies and kits; Phase II investigator-sponsored trial of cancer vaccine oncophage (vitespen) for recurrent, high-grade glioma, 2007.

R&D collaboration: NCI, NIAID, FDA, NSF grants. Technological expertise: S, D-D, DD Main products/instrumentation under R&D: Antiviral and anticancer immunomodulator drugs; drug carriers, viracol topical antiviral, Phase III/IV; natural products, immunomodulatory plant drug. Sealed and granted patents: 3 U.S., 2 PCT.

179 AORIS NOVA PTY, LTD. Add: Biomedical Building 1 Central Ave., The Australian Technology Park Eveleigh NSW 1430 Australia Tel: (61) 29209-4231 Fax: (61) 2-9209-4242

177 ANTITOXIN GMBH

E-mail: [email protected] Web site: www.aoris.com.au

Add: Schatthaeuser Strasse 6 Meckesheim D74909 Germany Tel: (49) 6226-7011 Fax: (49) 6226-7013 President: Dr. Ortwin Walla

President: Dr. Kelvin Hopper Research director: Dr. Robert Miller R&D expertise: Drugs research, patented licensing, business development and market strategy, consulting of pharmaceuticals.

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Joint ventures: Symbiotic Research Pty. Ltd.

Joint ventures: NitroMed, Inc.

Technological expertise: G, PA, C/TC, P/S, DD, D-D, GT, H/CF, PG, PMC

R&D collaboration: Ajinomoto Co., Tokyo; Duke University.

Principal products/instrumentation: Contract research/clinical trial products, laboratory diagnostics, biopharmaceuticals, vaccines, veterinary products.

Technological expertise: F, RD, BS

180 APATH, LLC. Add: 595 Anglum Rd. Hazelwood, MO 63042 Tel: (314) 731-8518 Fax: (314) 731-8880 E-mail: [email protected]

Main products/instrumentation under R&D: PHP (pyridoxalated hemoglobin ployoxyethylene), treat shock associated with SIRS (systemic inflammatory response syndrome), nitric oxideinduced shock, Phase III completed, 2008; PHPHT, Phase I/II; PHP-CT, preclinical; PHP-OC, preclinical; recombinant superoxide dismutase (research); NO synthase inhibitors (research). Sealed and granted patents: methods for the synthesis of a modified hemoglobin solution. 6,747,132, U.S.; others pending.

Web site: www.apath.com President: Dr. Charles M. Rice (Manager) Research director: Dr. Paul D. Olivo

182 APHIOS CORPORATION

R&D expertise: Research, development and production of virus diagnostics/therapeutics.

Add: 3-E Gill Street Woburn, MA 01801-1720

Technological expertise: C/TC, GA, G, HTDS, P/S, RD, Q, T

Fax: (781) 932-6865

Main products/instrumentation under R&D: Hepatitis C RNA Load ASSAY, preclinical; viral diagnostic novel agents, antiviral antibodies, antiviral proteins. Sealed and granted patents: U.S. Patent 5,976,836.

181 APEX BIOSCIENCE, INC. Add: 2810 Meridian Pkwy. Ste. 120 Durham, NC 27713 Tel: (919) 405-4000 Fax: (919) 405-4010 President/CEO: John A. Irick Research director: Joseph DeAngelo R&D expertise: Identify, develop, manufacture and commercialization of proprietary products based on hemoglobin & nitric oxide (NO) technologies.

Tel: (781) 932-6933 E-mail: [email protected] Web site: www.aphios.com President/CEO: Trevor P. Castor, Ph.D. Research director: Glenn T. Hong, Sc.D. R&D expertise: Improved drug discovery, development manufacturing and delivery of natural biotherapeutics; development of bioprocess engineering products; R&D of drug delivery, manufacturing. R&D collaboration: Alpha-Beta Technology, SmithKline Beecham, Vestar, JRH Biosciences, Intergen, Baxter, Bristol-Myers Squibb, Miles (Bayer), Orion-Farmos Technological expertise: CC, F, P/S, BA, DD, RD, Extraction & purification of paclitaxel & broystatin I, viral inactivation technology, drug delivery of hydrobhobic anti-cancer compounds such as paclitaxel and camprothecin. Principal products/instrumentation: Biologicals, specialty chemicals, vaccines, antibodies,

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peptides, enzymes, paclitaxel, taxol, taxosomes, camposomes.

Fax: (410) 633-3666

Main products/instrumentation under R&D: Natural product (Taxol) manufacturing — pilot and commercial; taxotere, taxus, drug delivery (Taxol and Camptothecin) — pilot and preclinical; virus inactivation, marine rnicroorganisms.

Web site: www.apogeedesigns.com

Sealed and granted patents: Taxol manufacturing, microbial cell disruption, liposome manufacturing.

183 APOCOM, INC. Add: 11020 Solway School Rd. Knoxville, TN 37931-2052 Tel: (865) 927-6120 Fax: (865) 927-6122 E-mail: [email protected]

E-mail: [email protected] President/CEO: Robert W. Flesher Research director: Kevin J. Barnes R&D expertise: Plastics design, development (thermoforming, vacuum forming) and manufacturing. Technological expertise: RM, CW, S Principal products/instrumentation: DNA Sequencer, DNA synthesizer, DNA thermal cycler, Electrophoresis; PCR Workstation; BioReactor, hollow fiber cell growth systems. Main products/instrumentation under R&D: Camera Imaging Station; Pipettors; Trans Illuminator, PCR DNA quantitation. Sealed and granted patents: DNA Sequencer, Pipettors, Automated DNA sequencer, other patents are pending.

Web site: www.apocom.com President: Dr. Robin Zimrner Research director: Ron Lee R&D expertise: Biotechnology Software R&D. Technological expertise: Q, BTS, RD, CH/S, BI

185 APOLIFE, INC. Add: 100 River Place, #5900 Detroit, MI 48207

Principal products/instrumentation: GRAIL Toolkit — protein coding region prediction and gene modeling using neural networks; high performance computing comparisons against several protein, DNA and Motif databases; GeneHound

Tel: (313) 446-2625

Main products/instrumentation under R&D: Frameshift error-correction, parallel computing versions for human and all major classes of model organisms, new type biotech drug software, R&D.

Research director: Dr. Robert Blackburn

184 APOGEE DESIGNS, LTD. Add: 101 S. Kane St. Baltimore, MD 21224 Tel: (410) 633-6336

Fax: (313) 446-2855 E-mail: [email protected] Web site: www.apolife.com President: Dr. Nalini Motwani R&D expertise: Research of Cell/tissue culture, recombinant monoclonal antibody production in yeast, immunotoxins. R&D collaboration: National Cancer Institute. Technological expertise: F, RD, H/CF, C/TC, GT, GA Principal products/instrumentation: Lowcost production system for recombinant antibodies.

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Main products/instrumentation under R&D: Immunotoxin, preclinical. Sealed and granted patents: Expression of heterologous multi-domain proteins in yeast 6, 358, 733, U.S.

186 APPLIED ANALYTICAL INDUSTRIES, INC.-AAI Add: 2320 Scientific Park Drive Wilmington, NC 28405 Tel: (910) 254-7000 Web site: www.AAiintl.com

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Principal products/instrumentation: ECIS (electric cell-substrate impedance sensing), an electrical measurement of cell behavior and motility in tissue culture; the model 100 now commercially available and can monitor up to 16 culture wells concurrently; ECIS 9600 cell growth monitor, a high-throughput instrument designed to monitor cells grown in special arrays, having a 96-well plate configuration, 2007. Main products/instrumentation under R&D: ECIS accessories for electroporation and wound healing; HTS and drug discovery via ECIS.

President/CEO: Fred Sancilio, Ph.D. R&D expertise: Contract researches all aspects of drug products development to the worldwide pharmaceutical and biotechnology industries, from preclinical dosage development to Phase I, II, III and IV clinical trials. Technological expertise: S, C/TC, CH/S, CC, DD, D-D, PIS, PMC, P/S, R, Q, SMC Principal products/instrumentation: Contract manufacturing products, nutraceuticals, biopharmaceuticals, enzymes, reagents, vaccines, natural products.

187 APPLIED BIOPHYSICS, INC. Add: 1223 People’s Ave. Troy, NY 121803535 Tel: (518) 276-2165 Fax: (518) 276-6380 E-mail: [email protected] Web site: www.biophysics.com President: Ivar Giaever Research director: Charles R. Keese R&D expertise: Research and development of laboratory biomedical instrumentation for biology and medicine. Technological expertise: C/TC, CH/S, HTDS

188 APPLIED BIOSYSTEMS Add: Molecular Biology Division 850 Lincoln Centre Dr. Foster City, CA 94404 Tel: (650) 570-6667 Fax: (650) 572-2743 Web site: www.pebio.com President: Andre F. Marion Research director: Robert Jones R&D expertise: Research, development and production of automated systems-instruments and associated chemicals — for life science research and related applications. Technological expertise: RD, P/S, GA, CH/S, SY, Q, AB Principal products/instrumentation: Protein sequencer; protein synthesizer, peptide synthesizer; DNA synthesizer; DNA sequencer; amino acid analyzer; DNA fragment analyzer; mass analyzer; data analysis systems; molecular biology lab station; DNA extractor; electrophoresis systems; HPLC systems; Genetic Analyzer, 2008; Veriti 96 Well Thermal Cycler with VeriFlex Blocks, 2007; DNA Purification Kit, 2007; PCR reagents, 2007. Main products/instrumentation under R&D: DNA analogs used for drug development studies,

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protein protease inhibitor, DNA detection kits, DNA database, DNA probe, all in development.

189 APPLIED GENETICS, INC. DERMATICS Add: 205 Buffalo Ave. Freeport. NY 11520 Tel: (516) 868-9026 Fax: (516) 868-9143 E-mail: [email protected] Web site: www.agiderm.com President/CEO: Daniel B. Yarosh, Ph.D. Research director: David Brown, Ph.D. R&D expertise: Development of DNA repairs technology, liposome dermatics research and related novel manufacture. Technological expertise: BA, C/TC, DD, D-D, E, P/S Principal products/instrumentation: Photosomes, Ultrasomes, Thiotaine and Oxysomes, DNA repairs technology. Main products/instrumentation under R&D: T4N5 liposomes, Mer minus Test, liposome dermatan, dermostatin. Sealed and granted patents: Liposome delivery to skin, diagnostic test for alkyltransferase.

R&D expertise: Development of membrane for bioreactors, oxygenation, purifications; Coatings for catalysis, oligosynthesis. R&D collaboration: Several joint product/ process developments. Key license and trade contracts: Savox Corporation. Technological expertise: BA, C/TC, COC, CH/S, GA, PIS, P/S, RB, TE, E, F Principal products/instrumentation: Biooxygenators, AEROX, 1992; Bioreactors membranes, Pervaporation Modules, 1998; Vapor Recovery Modules. Main products/instrumentation under R&D: Equipment for catalysis coatings, oligo synthesizer. Sealed and granted patents: Membranes, membrane devices, processes for gas and liquid transfer, and purification.

191 APPLIED PHYTOLOGICS, INC. Add: 410 N. Freeway Blvd. Sacramento, CA 95834-1219 Tel: (916) 921-6148 Fax: (916) 921-5611 E-mail: [email protected] Web site: www.apinc.com

190 APPLIED MEMBRANE TECHNOLOGY, INC. Add: 11558 Encore Circle Minnetonka, MN 55343 Tel: (623) 933-5121 Fax: (612) 933-8839 E-mail: [email protected] Web site: www.appliedmembranetech.com President/CEO: Stephen P. Conover Research director: Thomas McEvoy

President/CEO: Frank E. Hagie, Jr., Esq. Research director: Ming Huang, Ph.D., Senior Scientist R&D expertise: Develop, produce and market premium edible products incorporating as active ingredients formulated transgenic cereal seeds expressing value-added output traits. Technological expertise: C/TC, F Main products/instrumentation under R&D: Food supplement, performance similitude, nutraceuticals, nutrient, forfenimex similitude, multifunctional protein.

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192 APPLIED PRECISION, INC. Add: 1040 12th Ave. NW Issaquah, WA 98027-8929 Tel: (425) 557-1000 Fax: (425) 557-1055 E-mail: [email protected] Web site: www.appliedprecision.com President/CEO: Donald Snow Research director: Rich Fisler R&D expertise: Development of semiconductor industry products and biotechnology medicines research. Key license and trade contracts: University of California San Francisco — Deconvolution Technology.

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Joint ventures: U.S. Manufacture of Till Photonics high speed Monochromator for Fluorescence excitation. Technological expertise: CH/S, R Principal products/instrumentation: Hardware for microscopy; microscope condenser, microscopic slide, automated cell injection; precision X, Y stages and microscope focus controllers; X, Y scanning stages; complete imaging systems. Main products/instrumentation under R&D: Highspeed Polychrome I Monochromator for excitation of fluorescent probes and uncaging of compounds, highspeed monochromator for fluorescence excitation.

194 APPLIED SEPARATIONS, INC.

Technological expertise: BI, CH/S, HTDS Principal products/instrumentation: Delta Vision Restoration Microscopy System, 1994 array WoRx; Microarray Scanner, 1999; SoftWoRx Imaging Workstation. Main products/instrumentation under R&D: DNA Micro Array Scanners, apparatus for inspecting integrated circuit probe cards. Sealed and granted patents: Method and apparatus for inspecting integrated circuit probe cards.

193 APPLIED SCIENTIFIC, INC. Add: 29391 W. Enid Rd. Eugene, OR 97402 Tel: (541) 461-8181

Add: 930 Hamilton St. Allentown, PA 18101 Tel: (610) 770-0900 Fax: (610) 740-5520 E-mail: [email protected] Web site: www.appliedseparations.com President: Rolf Schlake R&D expertise: Drug separation, purification, analytical and production. Technological expertise: P/S, COC Principal products/instrumentation: Speed cartridges for solid phase extraction; Speed Wiz automated processor for solid phase extraction; Speed SFE supercritical fluid extraction instrument, automated analysizer for solid phase extraction.

Fax: (541) 461-4018 E-mail: [email protected] Web site: www.asiimaging.com

195 APPLIKON DEPENDABLE INSTRUMENTS

President: John Zemek Research director: Gary Rondeau R&D expertise: Development, design & manufacturing of scientific hardware.

Add: De Brauwweg 13 Schiedam 3125 AE Netherlands Tel: (31) 10-298-3555

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Fax: (31) 10-437-9648 E-mail: [email protected] President: Jan van Burg R&D expertise: R&D of Bioprocess engineering products; Bioreactor systems: Bioreactors, controller, software and peripherals. R&D collaboration: Delft University of Technology, Wageningen Agricultural University. Key license and trade contracts: Sonosep Biotech Inc.

and western Canada, 1459 Moore Place, Coquitlan, BC VoE; Mid-Atlantic, P.O. Box 750, Madison, Ng 07940.

197 APPROPRIATE TECHNICAL RESOURCES, INC. (ATR, INC.) Add: 9157 Whiskey BottonRd. P.O. Box 460 Laurel, MD 20725 Tel: (410) 792-0769

Technological expertise: F, BA, C/TC, H/CF, PMC, on-line analysis.

Fax: (410) 792-2837

Principal products/instrumentation: Bioreactor systems for vaccine production, bacterial cultures, tissue cultures, plant cell, fungi, sensors for biotechnology, biotech software and peripherals.

Web site: www.atrbiotech.com

196 APPLIKON, INC. Add: 1165 Chess Dr., Suite G Foster City, CA 94404-1113 Tel: (650) 578-1396 Fax: (650) 578-8836 E-mail: [email protected] Web site: www.applikon.com President: John Chary

E-mail: [email protected] President: Stephen Mitchell Research director: Stephen Mitchell R&D expertise: Development and production of a wide range of general purpose research equipment. Technological expertise: F, BME Principal products/instrumentation: DNA Processing System, ATR, (1996); Concentration Systems CS1, CS3, (Heto); Multitron-Shaking Incubators (Infers); Lyophilizers (Heto); Rotamix (ATR); SLxfors Multi-Fermenter (Infors), general purpose research equipment. Subsidiary bodies: (Sales & Service) ATR Biotech, 1552 E. Beach St., Emeryville, CA 94608.

R&D expertise: Biotechnology equipment R&D Technological expertise: BA, C/TC, CH/S, F, PMC, TE, LC/TC Principal products/instrumentation: Autoclavable and in situ bioreactors (1–1,200 liters) for microbial and cell culture processes; 1,030 biocontroller control system; Bio Watch and BioWorks fermentation software; perfusion devices, sensors, A-Sep on-line system. Subsidiary bodies: (201) 593-0212; New England Offices: 11 Nelshore Dr., Monticello, NY 1270 (914) 791-6429; Midwest office, PO Box 134, Prairie, WI 53590; Pacific Northwest

198 APTAGEN, INC. Add: 2190 Foxmill Rd. Herndon.VA 20171 Tel: (888) 367-4312 Fax: (703) 793- 8037 E-mail: [email protected] Web site: www.aptagen.com President/CEO: Colin Higbie Research director: Geoffrey Kidd R&D expertise: Research and development of DNA engineering and gene synthesis technologies

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to improve protein expression and protein function. Technological expertise: AB, BA, COC, D-D, E, G, HTDS, PG, RD, R, T Principal products/instrumentation: The Gene Forge for superior gene design and expression, Gene Forge, 1997. Main products/instrumentation under R&D: Manufacturing process for complex immunoproteins in order to lower the cost of drug deliver and FDA approval of biologics; rapid diagnostics for point-of-care testing of infectious diseases and to lower the cost of collecting data for FDA trials; DNA engineering and gene synthesis technologies.

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Technological expertise: BA, FE, BME Principal products/instrumentation: High press homogenisers and pumps, cell disruption homogenizers, high-pressure liquid chromatograph, high-rate biological filter.

201 AQUAGENE, INC. Add: 12085 Research Drive Alachua, FL 32615 Tel: (904) 418-1400 Fax: (904) 462-0875 E-mail: [email protected] Web site: www.aquagene.com President/CEO: John Rogers

199 APV HOMOGENISERS AS

Research director: Sharon D. Ogden, Ph.D.

Add: Roholmsvej 8 Albertslund/Copenhagen DK-2620 Denmark

R&D expertise: Research of molecular biology, transgenics, aquaculture; custom protein growth using transgenic fish.

Tel: (45) 43-666-600

Technological expertise: T, G

Fax: (45) 43-640-330

Principal products/instrumentation: Transgenic fish, protein growth fishs.

President: Gary Kedgley, Managing Director R&D expertise: Development and production of homogenisers and high pressure pumps.

202 AQUA-10 LABORATORIES

Technological expertise: BME, AMS, BC Principal products/instrumentation: Rannie and Gaulin homogenisers and high pressure pumps, two stage homogenizer.

Add: 153 Aqua-10 Rd. P.O. Box 818 Beaufort, NC 28616-0818 Tel: (919) 728-2270 Fax: (919) 728-5059

200 APV HOMOGENIZES GROUP

President: William E. Campbell Research director: Steven E. Ganpbell

Add: 500 Research Dr. Wilmington Technology Park Wilmington, MA 01887 Tel: (508) 988-9300 Fax: (508) 988-9111 President: David Duffin Research director: Richard R. Kinney R&D expertise: Research, development and production of cell disruption homogenizers, other bioprocess engineering products.

R&D expertise: Agriculture development/ manufacture. Technological expertise: F Principal products/instrumentation: AgriBLEND F401 foliant; AgriBLEND S301; AgriBLEND L201; AgriBLEND P404, agriculture pesticide. Sealed and granted patents: AgriBLEND F401, S301, L201, P404.

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Main products/instrumentation under R&D: Agrimycin, agricillin, agrobacteriocin.

203 AQUATEC DEVELOPMENT, INC. Add: 1543 Locke Lane Sugar Land, TX 77478-3917 Tel: (281)491-0808 Fax: (281) 242-7771 E-mail: [email protected] President: Howard W. Stern R&D expertise: Research and development of marine biomass to raw material nutraceuticals. Technological expertise: BA Principal products/instrumentation: Marine microalgae Concentrate Mass Production Technology-Pharmaceutical Quality — ready for extraction and use by the BIOTECHNOLOGY INDUSTRY. Protein isolates/carotenoids. Minerals and trace elements, Omega 3-Fatty acids. Very low-cost raw materials — cheaper than synthesizing — Available on very large scale. Marine nutraceutical raw material to biotech and food industry. Ready for orders. Marine nutraleutical extracts. Algea/Spirolina — mass production technology. Main products/instrumentation under R&D: Developed — ready for orders, marinobufagin, marine lipid concentrate (contain: omegasfatty acids, DHA, EPA), marinol other marine medicinals.

204 AQUILA BIOPHARMACEUTICALS, INC. Add: 175 Crossing Blvd. Framingham, MA 01702 Tel: (508) 766-2700 Fax: (508) 766-2705 E-mail: [email protected] Web site: www.aquilabio.com

President/CEO: Dr. Alison Taunton-Rigby Research director: Gerald Beltz R&D expertise: Creating and commercializing products that modulate the human immune system to treat or prevent infectious diseases and cancer. Key license and trade contracts: SmithKline Beecham, Pasteur Merieux Connaught, WyethLederie, Progenics, NASI, VaxGen. Technological expertise: F, RD, BA, P/S, DD Principal products/instrumentation: QuilvaxFeLV. Main products/instrumentation under R&D: Quilvax-L, quilvax-BM, quilimmune-P for pneumococcal infections in the elolerl Phase II completed, 2008; Quilimmune-M, quilirnmuneT, feline leukemia vaccine, immunomodulator nucleic acid derivative, protein hydrolysate oral. Sealed and granted patents: Nucleic, proteins, and methods of use of granulocytic ehrlichia 6,306,394, U.S.

205 AQUIONICS, INC. Add: 21 Kenton Lands Road Erlanger.KY 41018 Tel: (606) 341-0710 Fax: (606) 341-0350 E-mail: [email protected] Web site: www.aquionics.com President: Dave McCarty R&D expertise: Research of ultra violet, relative products manufacturing. Technological expertise: P/S Principal products/instrumentation: Ultraviolet technology, ultraviolet-visible detector.

206 ARBOR TECHNOLOGIES, INC. Add: 401 West Morgan Rd. Ann Arbor, MI 48108-9109

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R&D expertise: Research and development of electrophoresis systems, precast gels, protein separation, protein purification.

R&D expertise: Research and production of filtration devices for critical applications.

Key sales market contracts: Phenomena distributor in the USA, United Kingdom, Germany, Australia, New Zealand, Canada, and Puerto Rico.

Technological expertise: P/S

Technological expertise: BA, P/S

Principal products/instrumentation: PolyCap PES, PolyCap IF, SteriVent.

Principal products/instrumentation: Precast Gel Electrophoresis, SimpleGel electrophoresis, electrophoresis apparatus systems.

Research director: Tom Haddock

Main products/instrumentation under R&D: Whole blood filter, Autoprime, critical filtration devices. Sealed and granted patents: AutoPrime

207 ARCHAENZYME, LTD.

209 ARGENE, INC. Add: 198 N. Queens Ave. N. Massapequa, NY 11758 Tel: (888) 4 ARGENE

Add: Bldg. 13A Kiryat Weizmarm Science Park Ness Ziona Israel

Fax: (516) 795-4942

Tel: (972) 8-940-6210 Fax: (972) 8-940-8085

Web site: www.argenbiosoft.com/pages/ argeninc.htm

E-mail: [email protected]

President: Jean Larroque

CEO: Dr. Mathew Weisman

Research director: Alain Guerrey

R&D expertise: Development and production of ultrastable enzymes.

Subsidiary of Argene BioSoft

Technological expertise: E, F, P/S, GA Main products/instrumentation under R&D: Ultrastable enzymes for chemical synthesis; ultrastable enzymes for molecular biology.

208 ARCHIDEX Add: 2311 West 205th St., Ste. 101 Torrance, CA 90501 Tel: (310) 782-8192

E-mail: [email protected]

R&D expertise: Production and development of research monoclonal antibodies against viral, bacterial and parasitic antigens. Technological expertise: C/TC, PA Principal products/instrumentation: Monoclonal and polyclonal antibodies, BioSoft; molecular biology tools and kits, Cinakit, cinapool; hybridoma cell lines, hybridowell.

210 ARGONAUT TECHNOLOGIES, INC.

Fax: (310) 212-7085

Add: 887 Industrial Rd., Ste. G San Carlos, CA 94070

E-mail: [email protected]

Tel: (415) 598-1350

Web site: www.archidex.com

Fax: (415) 598-1359

Research director: Qi-Feng Ma

E-mail: [email protected]

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Web site: www.argotech.com President/CEO: David Binkley, Ph.D.

products for research; vaccines, general reagents, drug discovery route.

Research director: Paul van Eikeren, Ph.D. R&D expertise: Research and production of automated instrumentation & consumable products for chemistry.

212 ARIAD PHARMACEUTICALS, INC. Add: 26 Landsdowne St. Cambridge, MA 02139

R&D collaboration: Amgen, Berlex, BristolMyers Squibb, Merck, Pharmacopeia, Sandoz and SmithKline Beecham.

Tel: (617) 494-0400

Key sales market contracts: Sumitomo Corp.

Web site: www.ariad.com

Technological expertise: COC, CH/S, P/S, SMC, SY

President/CEO: Dr. Harvey Berger

Principal products/instrumentation: Nautilus 2400, Argogel Resin.

R&D expertise: Development and production of small-molecule drugs for the treatment of allergy/asthma, immune disease, osteoporosis and for regulation of gene therapy.

Main products/instrumentation under R&D: Additional instrumentation and resin families, resilin, coactivated resin, automated plastic instruments.

Fax: (617) 494-8144

Research director: Dr. Joan Brugge

R&D collaboration: Collaboration with Hoechst Marion Roussel on the development of drugs to treat osteoporosis. Technological expertise: SMC, GT, COC, D-D

211 ARGONEX, INC. Add: 706 Forest St., Ste. I Charlottesville, VA 22903 Tel: (804) 984-2040 Fax: (804) 984-1737 E-mail: [email protected] Web site: www.argonex.com President/CEO: Sheridan G. Synder Research director: Mark M. Ross R&D expertise: Research of reagents and drug discovery. Joint ventures: RheoGene (JV with ROHM & HAAS). R&D collaboration: Research collaborative agreement with Wyeth-Leyderle vaccines; Upstate Biotechnology Inc., U.S.; Upstate Biotechnology LTD, UK.

Main products/instrumentation under R&D: Signal transduction inhibitors for osteoporosis, immune disease and allergy/asthma (preclinical), reculated gene theraphy system (preclinical), methods involving conditional retention domains, small-molecule drugs for regulation of gene therapy; Phase II trial of oral ridaforolimus (mTOR inhibitor) in patients with metastatic solid tumors, 2009. Sealed and granted patents: Materials and methods involving conditional retention domains 6,566,073, U.S.

213 ARIES SCIENTIFIC, INC. Add: 1243 American Pkwy. Richardson, TX 75081 Tel: (972)783-7083

Technological expertise: C/TC, HTDS, PIS, Q

Fax: (972) 783-1818

Principal products/instrumentation: Manufactures & Markets Cell Signaling Reagent

E-mail: [email protected] Web site: www.ariesscientific.com

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President: Joe Foust

Fax: (207) 854-0867

Research director: Jeff Foust

Web site: www.artel-usa.com

R&D expertise: Development and production of animal serums and animal glands, organs and tissues.

President: Kirby Pilcher

Technological expertise: C/TC Principal products/instrumentation: Animal serums albumin, animal glands, animal organs, animal tissues.

214 ARONEX PHARMACEUTICALS, INC.

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R&D expertise: Development and production of analytical instruments and systems for pipette calibration. Technological expertise: BME, AMS Principal products/instrumentation: PCS (Pipette Calibration System), DP (Differential Photometer)

216 ARTHUR TECHNOLOGY

Add: 8707 Technology Forest PL The Woodlands, TX 77381

Add: Fond du Lac, WI 54936-1236

Tel: (281)367-1666

Tel: (414) 922-6970

Fax: (281) 3674676

Fax: (414) 922-1085

Web site: www.aronex.com

Web site: www.arthurtech.com

President: Geoffrey F. Cox, Ph.D.

President: Robert M. Arthur, Ph.D.

Research director: Paul Cossum, Ph.D.

R&D expertise: Biological monitoring of any living system using respirometers.

R&D expertise: Research, discovery and development of proprietary innovative medicines to treat cancer and life-threatening infectious disease.

Technological expertise: BA, PMC Principal products/instrumentation: Laboratory and on-line respirometers.

Key sales market contracts: Genzyme Corporation and Group Ferrer International, S.A. 217 ARTISAN INDUSTRIES, INC.

Key license and trade contracts: Baylor College of Medicine, basic technology; M.D. Anderson Cancer Center; Boehringer Mannheim, GmbH.

Add: 73 Pond St. Waltham, MA 02451

Technological expertise: AF, DD

Tel: (718) 893-6800

Main products/instrumentation under R&D: Nyotran for systemic fungal infections, Phase III/IV; Atragen for acute promyelocytic leukemia, Phase III; Annamycin for breast cancer Phase III; Zintevir for HIV Phase II/III.

Fax: (781) 893-6800 E-mail: [email protected] Web site: www.artisanind.com President: Andrew Donovan Research director: Joseph Qualitz, Ph.D.

215 ARTEL, INC. Add: 25 Bradley Drive Westbrook, ME 04092 Tel: (207) 854-0860

R&D expertise: Specialized professional equipment & custom-engineered systems with integrated process controls for medical, chemical process & biotech fields, University of Maryland, Baltimore.

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Technological expertise: F, BA, C/TC, PMC, L, E, bioreactors, membrane filtration devices. Principal products/instrumentation: CELLStation fully-automated 5L & 10L validatable mechanically-stirred bioreactors, pilot scale bioreactors, medium addition tanks, cell homogenizers, waste sterilization systems for production-scale bioprocessing, OEM for ultrafilters and blood analyzers; Standard and Custom designed equipment for the recovery of biological compounds (Active Pharmaceutical Ingredients and Intermediates) from solvent containing solutions. For example, the Rotothern recovers and recycles solvents from Simulated Moving Bed (SMB) chromatography systems, equipment to purify and recover heat sensitive biologicals from viscous, foaming, or fouling streams. Main products/instrumentation under R&D: 50 Liter and larger fully automated bioreactors and fermenters compatible with CELLStation Control Software; bench scale fully automated fermenter, process control and monitoring packages for use with all bioreactors and fermentors.

219 ASAHI CHEMICAL INDUSTRY CO., LTD. Add: 9-1, Kanda Mitoshirocho Chiyodaku Tokyo 101-8481 Japan Tel: (81) 3-3259-5723 Fax: (81) 3-3259-5725 President: Kazumoto Yamamoto Research director: Hiroo Nakano, Ph.D. R&D expertise: Research and development of chemicals, plastics, membrane, fiber, medical products, housing. Technological expertise: RD, F, P/S, BA, H/CF, C/TC, E, D-D, AB, DD, T, GT Principal products/instrumentation: Planova membrane-virus removal 1988; Leona nylon 66 resin and fiber; Hebel housing; Bemberg Cupra; Roica spandex; diagnostics, Filter “Planova”

220 ASA RULE, INC. Add: 225 Crescent St. Waltham, MA 02154 Tel: (617) 647-5598 Fax: (617) 647-7746

218 ASAHI CHEMICAL INDUSTRY AMERICA, INC. Add: 1400 East Lake Cook Road Ste 120 Buffalo Grove, IL 60089 Tel: (847) 353-8888 Fax: (847) 353-8877 Web site: www.planovafilters.com President/CEO: Yoshihisa Iwasaki Research director: Hiroo Nakano Subsidiary of Asahi Chemical R&D expertise: Research of virus removal filtration during purification of biopharmaceuticals. Technological expertise: P/S Principal products/instrumentation: Planova Virus Filter, virus absorption removal filter.

President/CEO: Allyn H. Rule, Ph.D. R&D expertise: R&D for noninvasive diagnostic tests (diabetes, fertility, ovulation, cancer). Technological expertise: DD, PA, SMC Key sales market contracts: Diabetes-urine test, preclinicals and clinicals with 550 patients; fertility, ovulation (human), preclinical; cows, early clinicals. Main products/instrumentation under R&D: Diabetes-urine test, noninvasive diagnostic test for human ovulation and cancer.

221 ASHBY SCIENTIFIC, LTD. Add: Unit 11, Atlas Ct. Hermitage Ind. Estate Coalville, Leicestershire LE67 3FL UK

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Tel: (44) 01 530-832590

Fax: (7) 95-190-1213

Fax: (44) 01 530-832591

E-mail: [email protected]

E-mail: [email protected]

Web site: www.asinex.com

Web site: www.ashyby-scientific.co.uk

CEO: Alexander Solovyov

President: G. Guidetti

Research director: Prof. Mikhail Kirpichenok

Research director: J. P. Fuller

R&D expertise: Collection of new hand-made organic compounds.

R&D expertise: Development and distribution of novel and innovative biotechnology process AIDS.

Technological expertise: CH/S, D-D, SMC, SY, AF, COC, HTDS

Technological expertise: F, PA, TE, BA, C/TC, H/CF, cell immobilization.

Principal products/instrumentation: Library of 130,000 handcrafted small molecules.

Principal products/instrumentation: Biologicals, vaccines, specialty chemicals, monoclonal antibodies, Immobasil, Textursil.

Main products/instrumentation under R&D: Reagents for synthesis.

Main products/instrumentation under R&D: Filtrasil.

222 ASI

224 ASIST, INC. Add: 5405 E. Schaaf Rd. Cleveland, OH 44131 Tel: (216) 642-8515

Add: 4126 Lakeside Dr. Richmond, CA 94806

Fax: (216) 642-9700

Tel: (510) 669-2250

E-mail: [email protected]

Fax: (510) 223-9670

President: Michael Markelov

E-mail: [email protected]

Research director: M. Markelov

Web site: www.hplc-asi.com

R&D expertise: Research and development of equipment and instrumentation.

President: Steve Graham R&D expertise: Development and production of luminometers, analytical instruments for HPLC. Technological expertise: BME, DKHC, CPHC Principal products/instrumentation: Selfpriming check valves for HPLC, post column reactor, luminometer, static mixers, flow splitter.

Technological expertise: DD, M, P/S, PMC Main products/instrumentation under R&D: Natural products, Headspace Autosampler Appavatus. Sealed and granted patents: Patent #5,441,700; Aug. 15, 1995 — “Headspace Autosampler Apparatus”.

225 ASPER, LTD. 223 ASINEX, LTD.

Add: 3 Oru St. Tartu 51014 Estonia

Add: 6 Schukinskaya ulitsa Moscow 123182 Russia

Tel: (372) 7-441-556

Tel: (7) 95-190-7960

E-mail: [email protected]

Fax: (372) 7-442-343

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Web site: www.asperbio.com President: Andres Metspalu, Ph.D. Research director: Neeme Tonisson R&D expertise: Research, development and production of genotyping on chips. Joint ventures: Se.Ge. Sta S.r.l. R&D collaboration: Estla Ltd., www.estla. com; Columbia University of New York; Cytotest Cell Research GmbH; International Agency for Research on Cancer. Key license and trade contracts: Amersham Pharmacia Biotech. Technological expertise: Q, CH/S, G, R Principal products/instrumentation: Genorama image detection hardware and software, 2000; coated slides for chip. Main products/instrumentation under R&D: DNA chips for genotyping/sequencing. Subsidiary bodies: Bioinformatics group started. Sealed and granted patents: 2 patents filed.

226 ASSOCIATES OF CAPE COD, INC. Add: 70 Main St. Falmouth, MA 02540 Tel: (800) 848-3248; (508) 540-3444 Fax: (508) 540-8680 E-mail: [email protected] Web site: www.acciusa.com

devices, Pyrochrome, Pyrotell-T, marinobufagin, W 3-marine fatty acids. Main products/instrumentation under R&D: Lipopolysaccharide binding protein for clinical, diagnostic and product purifications; reader for conducting assays. Sealed and granted patents: Reader for conducting assays 6,900,059, U.S.

227 ASTEC MICROFLOW, LTD. Add: 30-31 Lynx Crescent Weston Super Mare Somerset BS24 9BP UK Tel: (44) 19-3441-0500 Fax: (44) 19-3441-0546 Web site: www.astec-microflow.co.uk President: Andrew Daintree, M.D. Research director: Beverly Curtis R&D expertise: Design and production of fume filtration equipment including fume cupboards, downflow benches. Technological expertise: IF, AB, BI, BS, CB, C/TC, CC, COC, CH/S, DD, D-D, E, F, GA, GT, HTDS, H/CF, PIS, PA, PMC, P/S, RD, R, Q, SMC, SY, TE, T Principal products/instrumentation: Astec sensair fume cupboard, vaccines, reagents, natural products, natural auxin. Sealed and granted patents: Filter damping.

President/CEO: Thomas J. Novitsky, Ph.D. Research director: Paul A. Ketchum, Ph.D.

228 ASTELL SCIENTIFIC

R&D expertise: Development and production of Limulus Amebocyte Lysate (LAL), lipopolysaccharide research, new products development from marine animals.

Add: Powerscroft Road Sidcup, Kent DAM 5DT UK

Technological expertise: BA, CH/S, E, F, P/S

Fax: (44) 18-1309-2036

Principal products/instrumentation: Pyrotell Limulus Amebocyte Lysate, Pyrosol reagent buffer, LAL-5000 automatic endotoxin detection system, END-X B15 endotoxin removal

Tel: (44) 18-1809-2021 E-mail: [email protected] Web site: www.astell.com President: David Pennock

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R&D expertise: R&D and manufacture of sterilization and disinfection equipment. Technological expertise: BME, SI Principal products/instrumentation: Biologicals, cosmetics, veterinary products, contract R&D products, sterilization-disinfection devices.

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Principal products/instrumentation: Lubricious coating, Lubrilast, Anti-microbial coating.

231 ASTRA SCIENTIFIC, INC. Add: 7020 Roll Center Pkwy. Suite 130 Pleasanton, CA 94566 Tel: (925) 426-6900

229 ASTER BIOTECHNOLOGIES

Fax: (925) 426-6990 Add: Les Nertieres La Gaude 06610 France

E-mail: [email protected]

Tel: (33) 4-9324-7280

Web site: www.astrascientific.com

Fax: (33) 4-9324-7290

President: John D. Jones

President/CEO: M. Fehlmann Research director: M. Samson R&D expertise: Contract research immunology and products manufacture.

in

Technological expertise: C/TC, H/CF, PA, P/S Principal products/instrumentation: Specific immunoassays for drug measurements in pharmacokinetics. Main products/instrumentation under R&D: Process for non-invasive prenatal diagnosis using maternal blood, immunoassays for pharmacokinetics.

R&D expertise: Development, production, sales and marketing of laboratory instrumentation for drug research; internal software and value-added accessory development. Technological expertise: F, C/TC, PMC, CH/S Principal products/instrumentation: Astra Plus fermentation software for monitoring and control, Thermal Analysis Systems; PHT Dosage controllers; Reaction calorimeters.

232 ATARA CORPORATION 230 AST PRODUCTS, INC.

Add: 9700 Henri Bourassa W. St-Laurent, Quebec H4S 1R5 Canada

Add: 9 Linnell Circle Billerica, MA 01821

Tel: (514) 331-8332

Tel: (978) 667-4500

Fax: (514) 335-9346

Fax: (978) 667-9778

E-mail: [email protected]

E-mail: [email protected]

Web site: www.ataracorporation.com

Web site: www.astp.com

President/CEO: Michael J. Ogilvie

President: Dr. Ih-Houng Loh

Research director: Dev Jassal

Research director: Dr. Min-Shyan Sheu

R&D expertise: Development of instrumentation for waste water treatment.

R&D expertise: Development and production of medical coating and surface modification for biomedical devices and materials. Technological expertise: DD

R&D collaboration: National Research Council of Canada. Technological expertise: BA, P/S

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Principal products/instrumentation: Conveyors and mixing systems.

expression research services (Baculovirus and E. coli).

Main products/instrumentation under R&D: Atara NP-1 Reactor System-for wastewater treatment, pilot plants in operation.

Technological expertise: Q, P/S, RD, C/TC, GA

Sealed and granted patents: Bioreactor design and process.

Principal products/instrumentation: Biologicals, pharmaceuticals, agriculture, diagnostics, recombinant protein expression, contract research products.

233 ATCC 235 ATHENA DIAGNOSTICS, INC. Add: 10801 University Blvd. Manassas, VA 20110

Add: 377 Plantation St. Worcester, MA 01605

Tel: (703) 365-2700; (800) 638-6597

Tel: (508) 756-2886

Fax: (703) 365-2750

Fax: (508) 753-5601

E-mail: [email protected]

Web site: www.athenadiagnostics.com

Web site: www.atcc.org

President/CEO: Robert Flaherty

President: Dr. Raymond Cypess

Research director: Michael A. Boss, Ph.D.

Research director: Dr. David Barnes

Subsidiary of Athena Neurosciences, Inc.

R&D expertise: Non-profit bioscience organization focusing on biological cultures, education, information, & technology transfer.

R&D expertise: Clinical reference laboratory research for neurological disease diagnostics.

Joint ventures: Celox Corp., Informax, The Institute for Genomic Research (TIGR). Technological expertise: RD, BI, C/TC, H/CF Principal products/instrumentation: Biological cultures; PCR Mycoplasma Detection Kit.

Key license and trade contracts: Baylor College of Medicine; MIT; Univ. of Minnesota; Kyoto Univ.; Inserm; Mass. General Hospital; Columbia Univ.; Duke Univ.; Washington Univ. (St. Louis); Childrens Hospital, Boston; Cedars-Sinai Medical Center; Oxford Univ. (UK); Memorial Sloan Kettering. Technological expertise: Q, R

234 ATG LABORATORIES, INC. Add: 10300 Valley View Rd., Ste. 107 Eden Prairie, MN 55344

Principal products/instrumentation: Alzheimer’s disease diagnostics, ADMARK; Neutralizing antibody assay for interferon beta, NAbFeron, neurological disorder diagnostics.

Tel: (952) 829-7699 Fax: (952) 829-7693 E-mail: [email protected]

236 ATHENA NEUROSCIENCES, INC.

President: Julie A. Kirihara, Ph.D.

Add: 800 Gateway Blvd. So. San Francisco, CA 94080

Research director: Julie A. Kirihara, Ph.D.

Tel: (415) 877-0900

R&D expertise: Contract R&D; custom molecular biology and recombinant protein

Fax: (415) 877-8370

Web site: www.atglabsinc.com

E-mail: [email protected]

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President/CEO: John Groom Research director: Ivan Lieberburg, M.D. Subsidiary of Elum Corp., plc. R&D expertise: Biotechnology medicines research, development of therapeutics and diagnostics for neurological disorders. R&D collaboration: Eli Lilly, Elan, Wyeth Aerst. Key sales market contracts: Sandoz.

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plasma proteins and protein inhibitors, human serum albumin. Main products/instrumentation under R&D: Diagnostic assays for human disease.

238 ATHEROGENICS, INC. Add: 8995 Westside Parkway Alpharetta, GA 30004

Key license and trade contracts: Duke University, Sandoz.

Tel: (678) 336-2500

Technological expertise: E, F, PA, Q, SMC, SY, T, C/TC, D-D, HTDS, H/CF, P/S, RD

Web site: www.atherogenics.com

Principal products/instrumentation: Permax (registered trademark of Eli Lilly & Co., licensed to Athena.)

Research director: Uday Saxena, Ph.D., Vice President

Main products/instrumentation under R&D: Zanaflex (tizanidine), post Phase III/IV; Diastat (viscous solution of diazepam), filed; Bot B (botulinum toxin type B), Phase II/III; Antegren (monoclonal antibody) Phase III.

237 ATHENS RESEARCH AND TECHNOLOGY, INC. Add: P.O. Box 5494 Athens, GA 30604

Fax: (678) 336-2501 President/CEO: Russell Medford, MD, Ph.D.

R&D expertise: BioPharmaceuticals design and development. Technological expertise: T, D-D, RD, C/TC, SMC, PG Main products/instrumentation under R&D: AGl-l 067, Phase II; small molecule drugs, cell/tissue culture products, recombinant DNA synthesis. Sealed and granted patents: U.S. Patent 5,380,747.

Tel: (706) 546-0207 Fax: (706) 546-7395

239 ATHERSYS, INC.

E-mail: [email protected] Web site: www.athensresearch.com President: Hillary R. Newland, M.D. Research director: Virginia B. Patel, Ph.D. R&D expertise: Development of bioprocess engineering products; purification of proteins from human serum and tissue; development of diagnostic assays for both human and animal disease. Technological expertise: E, L, P/S, H/CF, C/TC Principal products/instrumentation: ART biochemicals: a line of highly purified human

Add: 3201 Carnegie Ave. Cleveland, OH 44115-2634 Tel: (216) 431-9900 Fax: (216) 361-9495 E-mail: [email protected] Web site: www.athersys.com President/CEO: Gil Van Bokkelen, Ph.D. Research director: John Harrington, Ph.D. R&D expertise: Research and development of biotechnology medicines products for the treatment of human diseases; identification,

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development and commercialization of therapeutics that extend and enhance human life. R&D collaboration: Case Western Reserve University, Cleveland Clinic Foundation, with Elan Corporation, plc, Case Western Reserve University, Cleveland Clinic Foundation. Key license and trade contracts: Case Western Reserve University, Athersys receives exclusive rights to the Synthetic Microchromosome vector technology. Technological expertise: RD, GT, G Main products/instrumentation under R&D: Two novel, proprietary platform technologies: the RAGE gene discovery and gene expression technology, the synthetic microchromosome vector system for gene therapy. RAGE, a novel, enabling technology that can activate and express proteins from any gene in an eukaryotic genome, without cloning the genes that encode each protein; Phase I trial of “offthe-shelf” adult stem cell product, MultiStem, in the treatment of ischemic stroke, 2008. Sealed and granted patents: Compositions and methods for non-targeted activation of endogenous genes. 6,410,266, U.S.; Compositions and methods for non-targeted activation of endogenous genes. 6,670,185, U.S.; Compositions and methods for non-targeted activation of endogenous genes. 6,602,686, U.S.; artificial human Compositions and methods for non-targeted activation of endogenous genes. U.S. others pending.

Principal products/instrumentation: Sealife, Nitrozyme, plant fertilizer, animal feed supplement.

241 ATLANTIC PHARMACEUTICALS, INC. Add: 1017 Main Campus Dr., Suite 3900 Raleigh, NC 27606 Tel: (919) 513-7020 Fax: (919) 513-7021 E-mail: [email protected] Web site: www.atlan.com President/CEO: J.D. Lindjord Research director: Stephen R. Miller, M.D. R&D expertise: Early development of a variety of antibodies, other biomedical products and devices. Technological expertise: AB Main products/instrumentation under R&D: Cataract removal device, antisense treatment drugs for RSV, CML; platform technology, sulfate cyclodextrins for restenosis and analgesic and anti-inflammatory agent — all preclinical. Sealed and granted patents: 2.5A antisense patent, cataract device patent, composition of matter and use patents on other agents.

242 ATLANTIC SOFTWARE 240 ATLANTIC LABORATORIES, INC.

Add: P.O. Box 299 Wenham, MA 01984 Tel: (508) 922-4332

Add: 41 Cross St. Waldoboro, ME 04572

E-mail: [email protected]

Tel: (207) 832-5376

President: Emile M. Bellott

Fax: (207) 832-6905

R&D expertise: Scientific and educational software for chemistry and molecular biology laboratory research.

President/CEO: Robert Morse R&D expertise: Research of processing seaweed for plant fertilizer, soil conditioner, animal feed supplement, food grade nutritional supplement. Technological expertise: P/S, BA

Technological expertise: Q, D-D, CH/S, BI Principal products/instrumentation: Protein Predictor; DNA/RNA Builder.

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243 ATOMERGIC CHEMETALS CORP.

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Tel: (970) 482-5868 Fax: (970) 482-9735

Add: 71 Carolyn Blvd. Farmingdale, NY 11735

E-mail: [email protected]

Tel: (631) 694-9000

Web site: www.atrixlabs.com

Fax: (631) 694-9177

President: G. Lee Southard, Ph.D.

E-mail: [email protected]

Research director: Richard L. Sunn, Ph.D.

President/CEO: Michael Roifberg, Ph.D.

R&D expertise: Research, develops, manufactures & markets of dental, medical and veterinary products based biodegradable drug delivery and biomaterial technology.

R&D expertise: Development and production of niche products. Technological expertise: F, RD, SY Principal products/instrumentation: High purity specialty chemicals, single crystals, stable isotopes. Main products/instrumentation under R&D: Bacteria for bioremediation; denatured compounds and aversive agents.

244 ATOM SCIENCES, INC.

R&D collaboration: Pfizer (undisclosed veterinary product). Key sales market contracts: Block Drug Corp (ATRISORB GTR Barrier, ATRIDOX subgingival antibiotic, other dental products in development). Key license and trade contracts: GensiaSicor (Ieuprolide), HESKA Corp. (periodontal treatment for companion animals). Technological expertise: C/TC, DD, TE

Add: 114 Ridgeway Center Oak Ridge, TN 37830 Tel: (865) 483-1113 Fax: (865) 483-3316 E-mail: [email protected] Web site: www.atom-sci.com President: Tom Whitaker Research director: Ken Willey R&D expertise: Biotechnology medicine equipment research and products development. Technological expertise: Q Main products/instrumentation under R&D: Biosensor Arrays, Phase III; DNA sequencer, DNA synthesizer. Sealed and granted patents: DNA sequencing by hybridization with unlabeled DNA

Principal products/instrumentation: ATRISORB: GTR Barrier. Main products/instrumentation under R&D: ATRIDOX subgingival antibiotic therapy for periodontal disease-NDA submitted 3/31/97, ATRISORB Barrier with doxycycline (preclinical); ATRISORB Barrier with growth factors (preclinical); ATRIGEL with leuprolide acetate (preclinical). Subsidiary bodies: 701 Centre Dr., Ft. Collins, CO — manufacturing facility; Sharp Point Dr., Ft. Collins, CO — pilot manufacturing facility. Sealed and granted patents: U.S. (14 issued, 17 pending); ex-U.S. (11 issued, 42 pending).

246 ATUGEN AKTIENGESELLSHAFT 245 ATRIX LABORATORIES, INC. Add: 2579 Midpoint Dr. Fort Collins, CO 80525-4417

Add: R.- Roessle- Str. 10 Berlin 13125 Germany Tel: (49) 30-9489-2700

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Fax: (49) 30-9489-2701 E-mail: [email protected] Web site: www.atugen.com

International Publication W097/21449; EPO Application 96942947.1; Japan Application 522165/97; Canada Application 240,327; P. R. China Application 96199015.5.

CEO: Michael Steinmetz, Ph.D. Research director: Klaus Giese, Ph.D. Subsidiary of ATUGEN USA, INC. R&D expertise: Research of target validation and discovery; transgenic development services. R&D collaboration: Berlex, Roche, Chiron, Glaxo Wellcome. Technological expertise: T, BI, G, P/S, RD Main products/instrumentation under R&D: Transgenic animal, RPIs ribozyme technology, target validation.

248 AURORA BIOSCIENCES CORPORATION Add: 11010 Torreyana Rd. San Diego, CA 92121 Tel: (619) 452-5000 Fax: (619) 452-5723 E-mail: [email protected] Web site: www.aurorabio.com

Subsidiary bodies: ATUGEN USA, INC.; Boulder, Colorado

President/CEO: Timothy J. Rink, M.D., Sc.D.

Sealed and granted patents: Exclusive worldwide licenses for RPI’s ribozyme technology.

R&D expertise: Drug discovery, drug design and production technology.

247 AUROGEN, INC. Add: 202 Remington Street PO Box B Fort Collins, CO 80522 Tel: (970) 491-7339 E-mail: [email protected]

Research director: Paul J. England, Ph.D.

R&D collaboration: Merck & Co., Eli Lilly, Bristol Myers Squibb, Warner-Lambert, Arqule, SIDDCO, Cytovia, Alanex. Key license and trade contracts: OSI Pharmaceuticals, SIBLA Neurosciences, Xenometrix, LIDAK Pharmaceuticals, and UCSD. Technological expertise: BI, HTDS, PG

Research director: Dr. Douglas N. Ishii

Main products/instrumentation under R&D: Drug screening route, drug-resistance strain, drug design program, vaccines reagents, antibodies.

R&D expertise: Research and development of diabetic neuropathy; Parkinson’s disease; Head trauma.

Sealed and granted patents: #5,777,079, #5,625,048, #5,741,657, #5,661,035, #5,070,012, #4,680,275.

Web site: www.aurogen.com CEO: Dr. Douglas N. Ishii

Technological expertise: F, Q, T, C/TC, CH/S, DD, GA, P.S, RD Main products/instrumentation under R&D: IGF for diabetic neuropathy, Phase II; Systemic IGF for Parkinsons, Preclinical; rh EGF for diabetic ulcer; rh TGF for trauma. Sealed and granted patents: U.S. Patent 5,817,623; U.S. Patent Application 08/571,802;

249 AURX, INC. Add: 500 McCormick Dr. Ste.J Glen Burnie. MD 21061 Tel: (410) 590-7610 Fax: (410) 590-2688

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251 AUSTRAL BIOLOGICALS

Web site: www.aurx.com Add: 125 Ryan Industrial Ct. Suite 207 San Ramon, CA 94583

President: Gary Calton Research director: Gary Calton R&D expertise: Research, development and production of herpes therapeutics, biotechnology medicines and vaccines. Technological expertise: E, PA, P, P/S, AB, C/TC, DD, GT Main products/instrumentation under R&D: Herpes-2 therapeutics, Phase II/III; HSV-2 diagnostic, pre-approval; Gene therapy, research; mixed vaccine, herpes vaccines.

Tel: (925) 820-8390 Fax: (925) 820-6843 E-mail: [email protected] Web site: www.australbio.com President: Cecilia Collados Research director: Kathryn Virello R&D expertise: Research/development of reagents and other biotech medicines. Technological expertise: PIS, PA, P/S

250 AUSPEP PTY, LTD. Add: P.O. Box 806 Parkville, Victoria 3052 Australia Tel: (613) 9328-1211 Fax: (613) 9326-8810

Main products/instrumentation under R&D: Additional growth factors, hormones, receptors and their antibodies, human tumor vaccines, epidermal growth factor.

E-mail: [email protected] Web site: www.auspep.com.au CEO: Chris Chandler, Ph.D. Subsidiary of Development

Australasian

Principal products/instrumentation: Growth factors, growth factor receptors, binding proteins, cytokines, enzymes, and their monoclonal and polyclonal antibodies for biological research market; MIPs; Monoclonal antibodies to cancer antigens, recombinant antigens and antibodies of viral and other infectious agents.

Drug

R&D expertise: Development and production of medical research peptides and specialty chemicals. Technological expertise: Q, PIS, P/S, SY Principal products/instrumentation: Catalog and custom peptides, custom iodination and conjugation of peptides, peptide antisera, amino acid derivatives and reagents for peptide synthesis, peptide library, peptide sequence, peptide synthesisers. Subsidiary bodies: Auspep LLC, 4350 Browns-boro Rd., Suite 110, The Summit, Louisville, KY 40207.

252 AUSTRALIAN PROTEOME ANALYSIS FACILITY Add: Level 4, building F7B Macquarie University North Ryde, Sydney, NSW. 2109 Australia Tel: (61) 2-9850-6201 Fax: (61) 2-9850-6200 E-mail: [email protected] Web site: www.proteome.org.au President: Professor Gary Gabon, Director R&D expertise: Biotechnology-proteomics research, products development.

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Technological expertise: Q, P/S, BI

E-mail: [email protected]

Principal products/instrumentation: Biologicals, contract research/products, proteolipid.

Web site: www.autogen.com

Main products/instrumentation under R&D: Proteoglycan, proteohormone, proteolysin.

253 AUTOGEN BIOCLEAR UK, LTD. Add: Holly Ditch Farm, Mile Elm Calne, Wilts SN11 0PY, UK Tel: (44) 0 1249-819008 Fax: (44) 0 1249-817266 E-mail: [email protected] Web site: www.autogen-bioclear.co.uk President: Chris Lear R&D expertise: Research of cell and molecular biology, biotechnology medicines development. Key sales market contracts: Santa Cruz Biotechnology, Inc.; Innogenetics BV; Advanced Biotechnologies, Inc; Dipro GesmbH, Owl Scientific. Bio Media, Q.E.D. ViroGen, Antigenix; Biochrom GMBH; Spectrum BV; Intracel, Inc.

President: Robert Sullivan CEO: Mikio Takahashi R&D expertise: DNA library development and management, nucleic acid extraction. Key sales market contracts: Anachem, Ltd. Key license and trade contracts: Kurabo Industries. Technological expertise: P/S, R Principal products/instrumentation: DNA library, including Autogen 740, Autogen 850X; Na 1000; Na 2000; Colony Picker available; The Auto-Genesys; Complete Robotic Platform (colony picking, gridding, replicating and rearraying) and the AutoGen prep: Automated Nucleic Acid Extraction (The Models are the 3000,2000,740 and 850 alpha). Main products/instrumentation under R&D: Array architecture and expression, gridding.

255 AUTOIMMUNE, INC. Add: 128 Spring St. Lexington, MA 02173

Technological expertise: PMC, H/CF, PA, C/TC

Tel: (617) 860-0710

Principal products/instrumentation: Santa Cruz Biotechnology antibodies, diagnostics, human genome project, organ transplants/ culture, vaccines, Bioclear fetal bovine serum, signal transduction antibodies, cell adhesion molecule, cytokines, infectious disease research products, neurochemical research products, culture media & sera, biotherapeutics.

President: Robert C. Bishop, Ph.D.

254 AUTOGEN, INC. Add: 35 Loring Dr. Framingham, MA 01702 Tel: (800) 292-5678 Fax: (508) 875-5329

Fax: (617) 860-0705 R&D expertise: Research and development of biopharmaceutical products based on the principle of oral tolerance for the treatment of immune system disorders. Key license and trade contracts: Eli Lilly for Diabetes. Technological expertise: RD, F, P/S, BA, C/TC, PMC Main products/instrumentation under R&D: Myloral for multiple sclerosis — Phase III/IV; Collrak for rheumatoid arthritis — Phase III; AI-300 for uveitis — Phase III; AI-401 for juvenile diabetes — Phase II.

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256 AUTOMATED CELL, INC.

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President/CEO: Gerald J. Yakatan Research director: Gerald J. Yakatan

Add: 390 William Pitt Way Pittsburgh, PA 15238 Fax: (412) 826-5215

R&D expertise: Research of biopharmaceuticalsimmunology and virology, relative products development.

E-mail: [email protected]

R&D collaboration: Ribi Immunochem.

Web site: www.automatedcell.com

Key sales market contracts: Molecular Probes.

President/CEO: Raymond K. Houck

Key license and trade contracts: Yamanouchi Europe, B.V.; Grelan Pharmaceuticals; Boryung Pharmaceuticals Company, Ltd., Bristol-Myers Squibb, GTS Industries, Cel-Sci Corp., Southern Research Institute.

Tel: (412) 826-5250

Research director: Alfred B. Bahnson, Ph.D. R&D expertise: Research of automated cell biology tools and therapeutics development (cell therapy and drug discovery). Technological expertise: BI, C/TC, COC, CH/S, GT, G, HTDS, P/S, TE, T Principal products/instrumentation: Biomaterials, drug discovery route, organ transplants, biopharmaceuticals, cell therapy program. 257 AUTOMATE SCIENTIFIC, INC.

Technological expertise: D-D, PIS Main products/instrumentation under R&D: LIDAKOL (n-docosanol) 10% cream, Phase III/IV, oral herpes; LP 2307 melanoma vaccine, Phase II/III; presents zenvia phase III safety data at the American Academy of Neurology Annual Meeting, 2010. Subsidiary bodies: 921 Bethlehem Pike, Spring House, PA 19477.

Add: 1801 Gouldin Rd. Oakland, CA 94611 Tel: (800) 998-6283 Fax: (510) 339-3190 E-mail: [email protected] Web site: www.autom8.com

259 AVANT IMMUNOTHEHAPEUTICS, INC.

President: Josef Kewekordes

Add: 119 Fourth Ave. Needham, MA 024942725

R&D expertise: Research, development and production of biotech apparatus/software.

Tel: (781) 433-0771

Technological expertise: CH/S, DD, HTDS Principal products/instrumentation: ValveBank; ValveLink Controllers; EasyCode Mac and PC.

Fax: (781) 433-0262 E-mail: [email protected] Web site: www.avantimmune.com President: Una S. Ryan, Ph.D. Research director: Henry C. Marsh, Jr., Ph.D.

258 AVANIR PHARMACEUTICALS Add: 9393 Towne Centre Dr. Ste. 200 San Diego, CA 92121 Tel: (858) 558-0364 Fax: (858) 453-5845 Web site: www.avanir.com

R&D expertise: Drug discovery, development and commercialization of products that harness the human immune response to prevent and treat disease. Products include preventive vaccines and immunotherapies that target diseases caused by infectious organisms, drugs and treatment vaccines that modify undesirable activity by the body’s own proteins or cells.

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Joint ventures: Joint discovery agreements with Ar-Qule and Repligen for small molecule immunoregulators. R&D collaboration: Novartis Pharma AG — Complement Inhibitor (TP10) for use in transplantation; Yamanouchi (Japan) — TP10 Heart attack study. Key sales market contracts: DiaMedix — Diagnostic products in U.S. Key license and trade contracts: Astra AB — T cell antigen receptor, based (TCAR) pharmaceuticals; CYto Therapeutics — complement receptor type 1 for cell therapy.

Enterococcus faecalis polynucleotide, polypeptides and method of use therefore. 6,376,235, U.S.; Plasmid-based vaccine for treating atherosclerosis. 6,284,533, U.S.; Immunoadjuvants. 6,261,573, U.S.; Human C3b/C4b receptor. 6,316,604, U.S.

260 AVAX TECHNOLOGIES, INC. Add: 4520 Main Street Kansas City, MO 64111 Tel: (816) 960-1333

Technological expertise: H/CF, RD

Fax: (816) 960-1334

Principal products/instrumentation: TRAX CD4 (diagnostic product).

E-mail: [email protected]

Main products/instrumentation under R&D: Cholera vaccine, Phase II completed, 2008; TPl0, also called sCRl: ARDS, Phase II/III; Reperfusion post myocardial infarction, Phase II completed; T cell activation inhibitors for the prevention of transplant rejection and autoimmune diseases, preclinical; Heart attack study, Phase II completed; Cholesteryl Ester Transfer Protein (CETP) vaccine for treatment of atherosclerosis, preclinical; Astra AB — T Cell Antigen Receptor (TCAR) program for the treatment of Multiple Sclerosis, Phase II completed; Rotavirus vaccine for infant rotavirus, Phase III completed; Adjumer Vaccines: Influenza, Phase III completed, Lyme Disease, Respiratory Syncytial Virus, Herpes Simplex Virus; Micromer Influenza Vaccine; RSV vaccine for treatment of respiratory syncytial virus, Phase III; Ty800, Phase II trial, single-dose oral typhoid vaccine, in about 180 healthy adults, 2009.

President/CEO: Dr. Jeffrey Jonas

Sealed and granted patents: Complement Receptor (CR1); Derivatives of CR1; Rotavirus; Adjurner Adjuvents; Micromer Adjuvents (2001); Regulated antigen delivery system (RADS). 6,780,406, U.S.; Modulation of cholesteryl ester transfer protein activity. 6,410,022, U.S.; IVI-2, IVI-3 and IVI-4 loci of

Web site: www.avax-tech.com Research director: Ernest Yankee R&D expertise: Development of drug products and technologies for the treatment of cancer and other life threatening diseases. Joint ventures: NIHL — Neptunus Intemation Holdings Limited, AC Vaccine Technology in Australia and New Zealand. R&D collaboration: Thomas Jefferson University, Rutgers University, Texas A&M. Technological expertise: AF, C/TC, DD Main products/instrumentation under R&D: Biologicals, pharmaceuticals, vaccines, AC Vaccine technology, M-Vax immune-based therapy, treat late-stage melanoma, Phase II completed 2008. Pivotal registration trial; OVax, ovarian cancer, Phase I; Topoisomeerase Inhibitors, preclinical; Anti-Estrogen Technology, preclinical.

261 AVECIA LIFESCIENCE MOLECULES Add: Gadbrook Park Northwich, Cheshire CW9 7RA UK Tel: (44) 1606-41100

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Fax: (44) 1606-49366 E-Mail: [email protected] Web site: www.avecia.com CEO: David Killworth Research director: Eric Atherton, Ph.D. R&D expertise: Development and manufacture of therapeutic grade peptides and oligonucleotides.

263 AVENTIS RESEARCH & TECHNOLOGIES GMBHDEVOFERM Add: Industriepark Hochst Building H777 Frankfurt am Main 65926 Germany Tel: (49) 69-305-7238 Fax: (49) 69-305-82938

Technological expertise: PIS, SY, AB, P/S

E-mail: [email protected]

Principal products/instrumentation: Therapeutic grade peptides; DNA chemistry, DNA cloning vector, custom oligonucleotides, recombinant proteins, small organic molecules.

Web site: www.devoferm.de

262 AVENTIS CROP SCIENCE N.V. Add: Jozef Plateaustraat 22 Gent 9000 Belgium Tel: (32) (0 9-235-8411 Fax: (32) (0) 9-2240694 CEO: Dr. Bernard Convent Research director: Dr. Bernard Convent R&D expertise: Agricultural biotech research and products development. Technological expertise: RD, C/TC, T, GA, Q Main products/instrumentation under R&D: Hybrid selection crops (canola, rice, vegetables); insert resistance, nucleic acid molecules of transgenic plant cells, transgenic plants. Sealed and granted patents: Nucleic acid molecules from wheat, transgenic plant cells and plants and the thereof for the production of modified starch. 6,462,256, U.S.; Method for producing transgenic plants with modified 5aminolevulinic acid biosynthesis, method for identifying 5-aminolevulinic acid synthesis effectors. 6,603,062, U.S.(2008); other patents pending.

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President: Dr. Schuller; Dr. Schadler Research director: Dr. Andreas SeiffertStoriko R&D expertise: Biotechnology drugs contract process development, contract product development, and manufacturing. R&D collaboration: Several customers especially Europe and USA Technological expertise: F, P/S Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, cosmetics, diagnostics, pesticides, vaccines, reagents, protein expression vector. Sealed and granted patents: Expression vector for the production of dead proteins. 6,582,691, U.S.; Disrupting cells and/or tissue in solid state in presence of solid denaturing substance 6,589,785, U.S.

264 AVERY BUSINESS DEVELOPMENT SERVICE Add: 2506 St. Michel Ct. Ponte Vedra Beach, FL 32082 Tel: (904) 285-6033 President: Henry Avery Joint ventures: Commercial Development Assoc Key sales market contracts: Mayo Clinic.

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Technological expertise: CC, CH/S, P/S, TE, GT

R&D expertise: Biotechnology products for liposome-related research & cell rupture.

R&D expertise: Development of tissue engineering, gene therapy and drug purification/ separation.

Technological expertise: F, LP, P/S, DD

Main products/instrumentation under R&D: Biomass, tissue bank, contract R&D products, gene therapy.

265 AVES LABS, INC. Add: PMB # 146 16200 S.W. Pacific Hwy, Ste. H Tigard, OR 97224 Tel: (503) 245-1858

Principal products/instrumentation: EmulsiFiex high-pressure homogenizing machines; LiposoFast, low-pressure homogenizers, Specialty chemicals, single cell proteins, biotech products food ingredients. Main products/instrumentation under R&D: Larger capacity homogenizers, two stage homogenizer.

267 AVI BIOPHARMA, INC.

Fax: (503) 245-8784

Add: 3450 Monte Villa Parkway, Bothell, WA 98021

E-mail: [email protected]

Tel: (425) 354-5038

Web site: www.aveslab.com

E-mail: [email protected]

President: Fazilah Adam

Web site: www.avibio.com

Research director: Gary Ciment, Ph.D.

President/CEO: Denis Burger, Ph.D.

R&D expertise: Chicken Antibodies development; Custom Antibody Production.

Research director: Dwight Weller, Ph.D.

Technological expertise: PIS, PA Principal products/instrumentation: AntiEpitope tag antibodies, chicken antibodies, custom antibodies, antibody finger printing.

266 AVESTIN, INC. Add: 2450 Don Reid Drive Ottawa, Ontario K1H 1E1 Canada Tel: (888) 283-7846 Fax: (613) 736-8086 E-mail: [email protected] Web site: www.Avestin.com President: Mark Ruzbie Research director: Mark Ruzbie President: Karl Riederce, Ph.D. Research director: Thomas Sauer, Ph.D.

R&D expertise: Drug delivery and antisense drug R&D. Technological expertise: AB, DD Principal products/instrumentation: Antisense drug, contract R&D products. Main products/instrumentation under R&D: Rester-IVG, treat cardiovascular restinosis, Phase I–II, 2008; antisense antiviral agent; AV1-4658 phase II trial for the treatment of Duchenne Muscular Dystrophy (DMD) by exon skipping, 2009. Subsidiary bodies: Corporate headquarters, Benj. Franklin Plaza, One SW Columbia, Suite 1105, Portland, OR 97258, Tel: (503) 2270554, Fax: (503) 227-0751. Sealed and granted patents: Antisense restenosis composition and method 7,094,765, U.S.; Antisense antiviral agent and method for treating ssRNA viral infection 6,828,105, U.S.; Antisense antiviral agent and method composition 6,677,153, U.S.

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268 AVIGENICS, INC. Add: Animal Science Complex 425 River Road Athens, GA 30602 Tel: (706) 227-1170 Fax: (706) 227-2180 E-mail: [email protected] Web site: www.avigenics.com President: Carl E. Marhaver R&D expertise: Biopharmaceutical production via transgenic chickens. Technological expertise: T Main products/instrumentation under R&D: Biopharmaceuticals. Sealed and granted patents: Ovomucoid promoter and methods of use. 6,875,588, U.S.; Three-dimensional array of supports for solidphase parallel synthesis and method of use. 6,872,535, U.S.; Poultry Derived Glycosylated Interferon Alpha 2b. 7,129,390, U.S.; High throughput screening assay for detecting a DNA sequence. 7,122,309, U.S.

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FIX preclinical, recombinant adeno-associated vector. Sealed and granted patents: High-efficiency wild-type-free AAV helper functions. 6,376,237, U.S.; Methods of treating disease using recombinant adeno-associated virus virions administered to muscle. 6,325,998, U.S.; Methods of treating Parkinson’s disease using recombinant adeno-associated vector. 6,309,634; 6,593,123, U.S.; Large-scale recombinant adeno-associated virus production and purification; Methods for delivering DNA to the bloodstream using recombinant adeno-associated virus vectors. 6,391,858, U.S.; Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith. 6,764,845, U.S.

270 AVIRON Add: 297 N. Bernardo Ave. Mountain View, CA 94043 Tel: (415) 919-6500

269 AVIGEN, INC.

Fax: (415) 919-6610 CEO: J. Leighton Read, M.D.

Add: 1201 Harbor Bay Pkwy., Suite 1000 Alameda, CA 94502 Tel: (510) 748-7150 Fax: (510) 748-7155 E-mail: [email protected] Web site: www.avigen.com President/CEO: John Monahan, Ph.D. R&D expertise: Gene therapy research, related novel products development. Technological expertise: GT Main products/instrumentation under R&D: AAV gene therapy treat hemophilia b, Phase I– II; thalassemia, Preclinical; Glioma — Preclinical; antiviral (HIV and hepatitis), Preclinical,

Research director: M. Bryant, M.D., Ph.D. R&D expertise: Prevention research/development

vaccines;

Technological expertise: RD, P/S, BA, C/TC, GT Main products/instrumentation under R&D: Vaccines for influenza, parainfluenza type-3 vaccine (live, attenuated bovine) for prevention of type-3 parain fluenza virus, herpes simplex, cytomegalovirus, respiratory syncytial virus, varicella zoster virus; influenza virus vaccine (live, attenuated) for prevention of influenza, Phase III completed; Epstein-Barr virus vaccine, for prevention of Epstein-Barr virus infection Phase II, 2008.

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271 AVIV INSTRUMENTS, INC. Add: 750 Vassar Ave. Lakewood, NT 087016907 Tel: (732) 367-1663

Sealed and granted patents: Methods for improving oral bioavailability of pharmaceutical compounds.

273 AXIOM INTERNET COMMERCE

Fax: (732) 370-0032 E-mail: [email protected] Web site: www.avivinst.com President/CEO: Jack Aviv R&D expertise: Research, development, and production of innovative instrumentation for science research.

Add: 21116 Vanowen St. Canoga Park, CA 91303-2821 Tel: (818) 346-2779 Fax: (818) 346-8443 E-mail: [email protected] Web site: www.axiominternet.com

Technological expertise: CC, SMC

President: Polly Teige CEO: John Teige

Principal products/instrumentation: Automated scanning titrating differential/ratio spectrofluorometer, circular dichroism spectrometer, stopped flow circular dichroism, stopped flow system, UV-VIS-NIR spectrophotometer, and automated titrating high stability filter fluorometer, circular dichroism spectrum, circular paper chromatography.

Research director: Jim Bullough

272 AVMAX, INC. Add: 385 Oyster Point Blvd. #9A South San Francisco, CA 94080 Tel: (650) 624-0130

R&D expertise: Design and development of software for biotech medicines research. Technological expertise: CH/S Principal products/instrumentation: Clinical Documentation System, AXIOM, Clinical Client 2000, Internet directed care. Main products/instrumentation under R&D: Internet directed care; direct disease specific medications; Care paths. These products are used to treat and heart failure (CHF, patients age 65+), pneumonia and cancer.

274 AXIS GENETICS PLC

Fax: (650) 624-0131 Web site: www.avmax.com

Add: Babraham Cambridge CB2 4AZ UK

President/CEO: Alan F. Russell, Ph.D.

Tel: (44) 12-2383-7611

Research director: Alan F. Russell, Ph.D.

Fax: (44) 12-2383-7604

R&D expertise: Research and development of oral Drug Delivery technology.

E-mail: [email protected] Web site: www.axisgenetics.co.uk

Joint ventures: ELAN Corporation, PLC.

CEO: Iain Cubitt, Ph.D.

Technological expertise: DD, HTDS, R, SMC, SY

Research director: Bill Hamilton, Ph.D.

Main products/instrumentation under R&D: Phase II; Oral Paclitaxel, Preclinical; oral drug delivery methods.

R&D expertise: Research/development of vaccines and other biotechnology medicines. R&D collaboration: Boyce Thompson Institute — oral plant vaccines; Roswell Park

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Cancer Institute — Hepatitis B Oral Plant Vaccine; Biornira Inc. — Therapeutic Cancer Vaccine; Roche Vitamins, Inc. — Plant Derived Vaccina in animal nutrition and health; American AG-TEC International, LTD. — Production of Hepatitis B Oral Plant Vaccine.

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276 AXONYX Add: 825 Third Ave., 40th Flr. New York, NY 10022 Tel: (212) 688-4770

Key license and trade contracts: Mycogen Corp. — edible plant vaccines.

Fax: (212) 688-4843

Technological expertise: BA, P/S, RD, T

Web site: www.axonyx.com

Main products/instrumentation under R&D: Travelers’ diarrhea vaccine, Phase II; oral plant vaccines, plant derived vaccines, plant derived vaccines, Phase II; Hepatitis B vaccine, Phase II; Norwalk virus vaccine; Phase II.

President: Marvin S. Hausman, Ph.D.

Sealed and granted patents: PCT/Ciba2/ 00589; PCT Ciba5/01618 — Chimaeric plant virus particles; Chimaeric virus particles, EP0580635, US5874087; Licenses to: Oral plant vaccines, US5654184, US5679880, US5686079.

Joint ventures: Ares Serono.

E-mail: [email protected]

Research director: Dr. Robert Burford R&D expertise: Research and development of therapeutic drugs for central nervous system disorder. R&D collaboration: NLA/NTH, NY6, University of Melbourne. Key sales market contracts: n/a. Key license and trade contracts: n/a. Technological expertise: DD, PIS

275 AXON INSTRUMENTS Add: 1101 Chess Dr. Foster City, CA 94404 Tel: (650) 571-9400 Fax: (650) 571-9500 E-mail: [email protected] Web site: www.axon.com R&D expertise: Design, development and manufacture of instruments and software for genomics, pharmaceutical screening, functional neurosurgery; cellular neuroscience, etc., and research. Technological expertise: BI, C/TC, CH/S, HTDS, PG, R Principal products/instrumentation: GenePix 4000 and GenePix Pro Microarray systems, GenePix, 1999; Electrophysiology data acquisition and analysis, pClamp, AxoPatcrf, AxoClarnp; Cellular Imaging, Axon Imagine Workbench; Neurosurgery, Guideline, genemics research software, pharmaceutical screening software.

Main products/instrumentation under R&D: Phenserine (acetylcholineslerase inhibitor — 3rd generation) for presenile demention, Phase II; Phenethylaym serine, Preclinical; Tolserine, Preclinical. Sealed and granted patents: Butyrylcholinesterase Inhibition, Amyloia Inhibitory Peptides, Acetylcholinesterase Inhibition; beta sheet breaker peptide analogs that beta pleated sheet formation in amyloid beta-peptide, 6,689,753, U.S.; other patents pending. 277 AXXIOM CHROMATOGRAPHY, INC. Add: 11968 Challenger Court Moorpark.CA 93021-7121 Tel: (805) 523-8888 Fax: (805) 523-7900 E-mail: [email protected] Web site: www.axxiomchromatography.com President/CEO: James Cole

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Research director: Alfred Welch, Jr.

CEO: Prof. Dr. E. Veltkamp

R&D expertise: Development and manufacture of data acquisition and instrument control systems for chromatography.

Research director: Dr. Laurens Sierkstra

Technological expertise: CH/S Principal products/instrumentation: 700 series data systems, PYRAMID chromatography manager, Solvent Recycler, Data System Validator, HPLC Low Pressure Gradient Controller, data acquisition/instrument control systems for chromatography.

R&D expertise: Research, development and manufacture of biotechnology-fermentation derived products, antibodies, peptides, enzymes; fermentation and downstream process development and up-scaling. Technological expertise: BA, F Principal products/instrumentation: Contract research products, anti-centromere antibodies, antinuclear antibodies, hybrid antibodies, natural antibodies, peptides, activating enzymes, restriction enzymes, transferring enzymes.

278 AZUR ENVIRONMENTAL Add: 2232 Rutherford Rd. Carlsbad, CA 92008 Tel: (760) 438-8282 Fax: (760) 438-2980 E-mail: [email protected] Web site: www.azurenv.com President/CEO: Dr. Anthony Bulich R&D expertise: Research and development of laboratory biomedical instrumentation. Technological expertise: PMC Principal products/instrumentation: Microtox Tat Systems, Microtox Acute Test, Microtox Chronic Test, Solid Phase Test, Mutatox Test, Insprectra Analyzer Microtex Omni software, environmental room, environmental pollutant detector.

279 BAC BV-BIOTECHNOLOGY APPLICATION CENTRE Add: Huizerstraatweg 28, 1411 GP Naarden P.O. Box 2, Bussurn Naarden 1411 GP Netherlands Tel: (31) 35-699-2595 Fax: (31) 35-694-9576 E-mail: [email protected] Web site: www.bac.nl

280 BACHEM AG Add: Hauptstrasse 144 Bubendorf CH-4416 Switzerland Tel: (41) 61-931-2333 Fax: (41) 61-931-2549 E-mail: [email protected] Web site: www.bachem.com President: Peter Grogg. Dr. h.c. Research director: Fritz Dick, Ph.D. R&D expertise: Development and manufacture of amino acid derivatives, peptides, peptide instrumentation and proteins to the research market and peptides as bulk drug for the pharmaceutical industry. Technological expertise: COC, CC, PA, SMC, P/S, SY, PIS, solid and solution phase synthesis of peptides, organic synthesis. Principal products/instrumentation: Peptides as research products and as bulk drugs, peptides screening devices, peptide sequencer, amino acid derivatives, resins for solid phase synthesis, cytokines, HIV peptides, interleukins, growth factors, enzyme substrates and inhibitors, bioactive peptides, amyloid peptides, monoclonal and polyclonal antibodies; Peptide synthesizers, countercurrent distribution apparatus, organic synthesizers, peptide library.

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Main products/instrumentation under R&D: Novel bioactive peptides, interleukins, cytokines, growth factors, monoclonal and polyclonal antibodies. Subsidiary bodies: BACHEM Bioscience Inc., King of Prussia, PA, USA; BACHEM Biochemica GmbH, Heidelberg, Germany; BACHEM Biochimie SARL, VoisinsleBretonneux, France; BACHEM California Inc., Torrance, CA, USA; BACHEM (UK) Ltd. St. Helens, Merseyside, England; Peninsula Laboratories Inc., San Carlos, CA, USA. Sealed and granted patents: EP 0292729; EP 0536710; EP 0292729; US 4.946.971; US 7,957.677; US 4.914.151; CH 682 662.

281 BACHEM AMERICAS Add: 3132 Kashiwa St. Torrance, CA 90505 Tel: (310) 539-4171; (888)4 BACHEM Fax: (310) 517-1571 E-mail: [email protected] Web site: www.bachem.com President: Jose de Chastonay, Ph.D. Research director: Alex Faessler, Ph.D. Subsidiary of Bachem AG, Switzerland R&D expertise: Research, development and production of peptides and peptide instrumentation, related novel products development/manufacture. Technological expertise: CS, CW, PI, PIS, PS, P/PS, PPAT. Principal products/instrumentation: Peptides produced including GMP grade peptides, custom synthesis, catalog products. Instrumentation including Labortec Peptide Synthesizers, Countes Current Distribution Apparatus. Main products/instrumentation under R&D: Varieties of New peptides and peptidemimetics; Amino acid derivatives, kits (EIA, RIA); Antibodies and proteins, peptide nucleic acid, peptide T, peptidase A isozyme, peptide sequencer, peptide synthesizer.

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Subsidiary bodies: Bachem California, Bachem Bioscience, Peninsula Laboratories.

282 BACHEM BIOSCIENCE, INC. Add: 3700 Horizon Dr. King of Prussia, PA 19406 Tel: (610) 239-0300; (800) 634-3183 Fax: (610) 239-0800 E-mail: [email protected] Web site: www.bachem.com President: Michael W. Pennington, Ph.D. Research director: Michael W. Pennington, Ph.D. Subsidiary of BACHEM AG, Switzerland R&D expertise: Custom development/manufacturing of biomedical products for biotechnology. Technological expertise: PIS, P/S, SY, RD, CS, Synthesis of amino acid derivatives and peptides. Principal products/instrumentation: Bulk peptide pharmaceuticals, research reagents, growth factors, lymphokines, enzyme substrates & inhibitors, monoclonal antibodies, HIV protease & related peptides, neuropeptides, neurotoxins, amino acids & derivatives, ICE substrates and inhibitors, HIV and HCV protease, substrates and inhibitors, bioactive peptides, amino acid derivatives, resins, peptide library, peptide sequencer. Subsidiary bodies: Bachem California, Torrance; Peninsula Laboratories. Sealed and granted patents: Sasrin Resin, ARG (PMC).

283 BACHEM CALIFORNIA, INC. Add: 3132 Kashiwa St. Torrance, CA 90505 Tel: (888) 422-2436; (310) 539-4171 Fax: (310) 530-1571

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E-mail: [email protected]

Technological expertise: F, AF, BA, P/S, SY

Web site: www.bachem.com

Principal products/instrumentation: Tylosin; Tobramycin; Apramycin; Sulbactam.

President: Dr. Jose de Chastonay Research director: Dr. J.-P. Durieux Subsidiary of Bachem Switzerland R&D expertise: Development of bioactive peptides for basic & clinical research; largescale GMP production of pharmaceutical grade peptides.

Main products/instrumentation under R&D: Xylanase; X-Amylase; bioactive polymer, proteolytic enzymes, redox enzymes.

285 BALL HORTICULTURAL CO.

Technological expertise: RD, P/S, SY, PIS, PA, LP, GMP-grade peptides.

Add: 622 Town Rd. West Chicago, IL 601852698

Principal products/instrumentation: GMPgrade product for clinical applications, including salmon calcitonin, Eel calcitonin, CRH, GRH, LHRH, dDAVP, somatostatin, ANF and hPTH, custom peptide synthesis and catalog products. Vaccines, Specialty chemicals, numerous peptides including calcitonin somat statin, corticotrophin-like intermediate lobe peptide (CLIP).

Tel: (630) 231-3600

Main products/instrumentation under R&D: Several bioactive novel peptides.

R&D collaboration: Sanford Scientific, Inc.; Scotts.

Subsidiary bodies: Bachem AG, Bubendorf, Switzerland; Bachem Bioscience, Inc., King of Prussia, PA, USA; Bachem Biochemica, GmbH, Heidelberg, Germany; Bachem Biochemie SARL, Voisinslo Brctonncux, France; Bachem (UK) Ltd., Walden Essex, England.

Technological expertise: C/TC, T

Fax: (630) 231-2590 Web site: www.ballseed.com President: Anna C. Ball Research director: Dr. Randal M. Hauptmann R&D expertise: Development and manufacture of ornamental horticulture/molding.

Principal products/instrumentation: Cut flowers, bedding & pot plants, flowering plants, transgenic plants, genetically modified plants. Sealed and granted patents: Various plant and process patents.

284 BALKANPHARMA-RAZGRAP 286 BALM PHARMACEUTICALS, LTD. Add: 68, “Aprilsko Vastanie” Blvd. 7200 Razgrad 7200 Bulgaria

Add: P.O. Box 2439 Rehovot 76123 Israel

Tel: (359) 84-2-4651

Tel: (972) 8-936-5431

Fax: (359) 84-3-4272

Fax: (972) 8-946-0484

E-mail: [email protected]

E-mail: [email protected]

Web site: www.antibiotic.bg

CEO: Nurit Eyal, Ph.D.

President: Vasil Vaslov

R&D expertise: Drug development and production.

Research director: Milen Kostadinov R&D expertise: Development of novel antibiotics, bioactivity substances and Industrial enzymes.

Technological expertise: AF, PIS Main products/instrumentation under R&D: Anticancer peptides; antibacterial peptide;

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antifungal peptides preclinical; antidiabetic peptides, peptidase, peptide hormone, peptide, antibiotic, peptide T, peptimaycin.

287 BANGALORE GENEI PRIVATE, LTD. Add: No. 6, 6th Main BDA Industrial Suburb Peenya Bangalore, Karnataka 560 058 India Tel: (91) 83-91453/83-96894 Fax: (91) 080-83-92825 President/CEO: P. Babu, Ph.D. Research director: P. Babu, Ph.D. R&D expertise: Development and production of restriction enzymes and other research reagents for genetic engineering and biotechnology research; also contract research. R&D collaboration: Astra Research Centre India, Bangalore; Indian Institute of Science, Bangalore.

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Key sales market contracts: Prolabo, distribution of Estapor microspheres; DYNO Spheres distribution agreement with DYNO Particles. Technological expertise: P/S, Q, COC, HTDS Principal products/instrumentation: ProActive Streptavidin, Protein A, and secondary antibody coated microspheres, uncoated microspheres made primarily of polystyrene, but also other polymers (dyed and undyed) and silica. All of CO. microspheres including plain (no surface functional groups) and surface functionalized with 1 of 13 different chemical groups for covalent ligand attachment. Flow Cytometry Standards Corporation microbead fluorescent standards. Main products/instrumentation under R&D: Protein-coated silica microspheres 0.4 microns to 5 microns, bioprocess technology monitoring control, process scale chromatography.

Technological expertise: E, F, P/S, RD, SY Principal products/instrumentation: Restriction enzymes, allosteric enzymes, catheptic enzymes, modifying enzymes, DNA vectors, DNA markers, custom oligonucleotides, second antibodies, antibody conjugates, stable substrates, enzymes for antibody conjugation, biologicals, molecular biology kits, bacterial strains, electrophoresis equipment and others.

289 BARENBRUG HOLDING BV Add: Oosterhout Njmegen, Gld. 6678 ZG Netherlands Tel: (31) 481-488100 Fax: (31) 481-488139 E-mail: [email protected] Web site: www.barenbrug.com

288 BANGS LABORATORIES, INC. Add: 9025 Technology Dr. Fishers, IN 460382886

President: H. J. M. Barenbrug Research director: Laurens Beerepoot

Fax: (317) 570-7034

R&D expertise: Development of marketing of seeds of turf grasses and forage crops. Transgenic plant breeding, seed production and marketing.

E-mail: [email protected]

Technological expertise: T, S, C/TC, RD, GA

Web site: www.bangslabs.com

Principal products/instrumentation: Seeds of turf grass varieties and forage crops.

Tel: (800) 387-0672; (317) 570-7020

President: Tom Penno Research director: Mary Meza R&D expertise: Microspheres and bioprocess engineering products R&D.

Main products/instrumentation under R&D: Transgenic varieties of grasses, clovers and alfalfa.

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290 BAR ILAN RESEARCH & DEVELOPMENT COMPANY, LTD. Add: P.O. Box 1530 Ramat Gan 52900 Israel Tel: (972) 3-531-8441 Fax: (972) 3-535-6088 E-mail: [email protected] Web site: www.biu.ac.il/birnd

Principal products/instrumentation: Masterflex tubing pumps; Vacuum pumps, Gilmont flowmeters; Manostat pumps; temperature sensors; mixers; pH; infusion-withdrawal pumps; chemical metering pumps. 292 BARTELS, INC.

CEO: Dr. Isser Peer

Add: 2005 NW Sammimish Rd. Ste. 107 Issaquah, WA 98027-5364

Research director: Mina Gutterman

Tel: (425) 392-2992

Subsidiary of Bar-Ilan University

Fax: (425) 392-0490

R&D expertise: Research of technology transfer for biotechnology pharmaceuticals, diagnostics, medical devices, agriculture, chemical process, high-tech physics and chemistry, applied mathematics and computer sciences.

E-mail: [email protected]

Technological expertise: CH/S, DD, GT, H/CF, PIS, PG, P/S, SMC, SY

R&D expertise: Research, design, development and manufacture of novel diagnostic and therapeutic products for oncological, cardiovascular, and infectious disease.

Principal products/instrumentation: Technology transfer of biotech medicine and related products.

291 BARNANT CO. Add: 28 W 092 Commercial Ave. Barrington, IL 60010 Tel: 1-800-637-3739 Fax: (847) 381-7053 E-mail: [email protected] Web site: www.barnant.com President: George Sezemsky Subsidiary of Cole-Parmer instrument Co. R&D expertise: Research, development and production of peristalic tubing pumps, vacuum pumps, temperature sensors and mixers, as well as flowmeters, manometers and other lab apparatus. Technological expertise: BME

Web site: www.intracel.com President: Dr. Michael Hanna Research director: Diana K. Goroff, Ph.D. Subsidiary of Intracel Corp.

Technological expertise: RD, P/S, H/CF, C/TC, SY, S, BA Principal products/instrumentation: Apo-Tek Lp(a), for quantitation of Lp(a) in plasma and serum; Apo-Tek Apo E, for quantitation of Apo E in plasma, serum and cerebrospinal fluid; BCIImmuneactivator; Retrobiral Recombinant Proteins; Monoclonal and Polyclonal Antibodies; Murine Antibody Reagents; Viral Respiratory Kit. Main products/instrumentation under R&D: HomaSpect Diagnostic Imaging: HomaSpect/Colorectal (PLA/MAA; HomaSpect/ Breast, Phase II/III; HornaSpect70var-ian, Phase II; HumaRad PIT Treatment: HumaRad/ Breast, Phase II; HurnaRad/Ovarian, Phase I; Head and Neck, Phase II. 293 BASF BIORESEARCH CORP. Add: 100 Research Dr. Worcester, MA 01605 Tel: (508) 849-2500

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Fax: (508) 752-6506 Web site: www.basf.com President: Robert Kamen, Ph.D. Research director: Pamela Barney R&D expertise: R&D of immunology and oncology drug products, contract cGMP manufacturing. R&D collaboration: Cambridge Antibody Technologies, Genetics Institute. Technological expertise: RD, BA, C/TC, SY, D-D, HTDS, P/S Principal products/instrumentation: Anticancer agent, immunopotentiating drug, enhanced immunologic function drug, bi-specific antibodies, complete antibodies.

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plus, Autopheresis C, cell harvester, Lifecell culture system, blood pack units, cell sorter. Main products/instrumentation under R&D: Hemoglobin solution, Phase II; Isolex 300, Phase II; Gene Therapy, preclinical; Fibrin sealant; Ceprotin (protein C concentrate (human) for treatment of protein C deficiency, IV, 2007; Phase III trial of Gammagard Liguid (intravenous immune globulin) for the treatment of mild to moderate Alzheimer's disease, 2008. Subsidiary bodies: Illinois, Florida, Washington, and California; Japan, Germany, Switzerland and Belgium. 295 B B INTERNATIONAL Add: Golden Gate, TY Glas Avenue Cardiff CF4 5DX UK

294 BAXTER HEALTHCARE CORP. BIOTECH GROUP

Tel: (44) 1222-747232 Fax: (44) 1222-747242

Add: 1627 Lake Cook Rd. Deerfield, IL 60015

E-mail: [email protected]

Tel: (708) 940-6599; (800) 241-9360

Web site: www.bb-international.com

Fax: (708) 940-6279

President/CEO: Dr. John Chandler

President: Timothy B. Anderson

R&D expertise: Contract research and development of rapid tests, contract manufacture of rapid tests.

Subsidiary of Baxter Healthcare R&D expertise: R&D of closed systems for the collection, storage and manipulation of cells, biopharmaceutical development, research of gene therapy and blood substitutes, novel products manufacture.

Technological expertise: DR, E, MAE Principal products/instrumentation: Immunogold reagents/rapid analysis test, rapid radioimmunoassay.

Joint ventures: Nextran, Neocrin. R&D collaboration: Somatix, Vical, UBI.

296 B. BRAUN BIOTECH, INC.

Key sales market contracts: Medlmmune, Imre, Kabi, Dynal.

Add: 999 Postal Rd. Allentown, PA 18103

Key license and trade contracts: Genetics Institute.

Fax: (610) 266-9319

Tel: (610) 266-6262

Technological expertise: RD, BS, C/TC, GT, P/S

Web site: www.bbraunbiotech.com

Principal products/instrumentation: Recombinate, recombinant plasmid, recombinant protein Garnmagard S/D, Isolex 300, CS-3000

Research director: Michael S. Smith

President: Thomas Ronca Subsidiary of B. Braun Biotech International

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R&D expertise: Biotech drug equipment R&D/manufacture. Key sales market contracts: Keofitt — sampling valves; ASi — glucose probe; Wheatonspinners and controllers. Technological expertise: F, BA, C/TC, PMC, CH/S, E Principal products/instrumentation: Fermentors and bioreactors — Biostat; Shakers — Certomat; Homogenizers — Labsonic; Spinners — Control tower; Process control — MFCS/Win, BioPro; Sterile Sample Valves — Keofitt.; purification devices by liquid extraction. Subsidiary bodies: B. Braun Biotech Intl., Schwarzenberger Weg 73-79, 34121 Melsungen, Germany. Sealed and granted patents: Fundaform; air filter assembly.

297 B BRAUN BIOTECH INTERNATIONAL GMBH Add: Schwarzenberger Weg 73-79 Melsungen 34212 Germany

and bioreactors, photobioreactors, fluidized bed bioreactors, CIP systems, Sterimedia, continuous sterilizers and media preparation systems, Spinferm, external and internal spinfilters for cell separation; Process automation systems, MFGS/wrn; Multi fermentor control system (SDADA); Certomat shakers and stackable incubator shakers, benchtop homogenizers, two stage homogenizers, centrifuges, process development equipment. Subsidiary bodies: USA: B. Braun Biotech Inc., 999 Postal Rd., Allentown, PA 18103, Tel:. (610) 266-6262, Fax (610) 266-9319; Spain: B. Braun Biotech S.A., Benet Mateu, 27-29 Entl. I. A, 08034 Barcelona, Tel: (34) 3280-2623, Fax: (34) 32-80-1581; Benelux B. Braun Biotech International, Olrnenlaan 34, 1750 Lennik, Tel. (32) 2532-0773, Fax: (32) 2532-1534; UK: B.M. Browne (UK) Ltd., Unit 2A, Pincents Kiln Industrial Park, Pincents Kiln/Cakot, Reading, RG31 7SD, Tel: (44) 118930-5333, Fax: (44) 11-8930-5111; Asia/Pacific Operation: B. Braun Biotech, Bayan Lepas Free Trade Zone, P.O. Box 880, 10810 Penang, Tel: (604) 8203-460, Fax: (604) 6435-723.

Tel: (49) 56-6171-3842 Fax: (49) 56-6171-3702

298 BBS SYSTEM, INC.

E-mail: [email protected] Web site: www.bbraun.com

Add: Schutzenmattstr 1 Bulach 8180 Switzerland

President: Dr. W. Kuhlmann

Tel: (407) 292-4812

R&D expertise: Design, development of manufacturing of professional instruments and process equipment for biotech industries and research institutions.

Fax: (407) 292-5306

Joint ventures: Diessel GmbH Hildesheim. R&D collaboration: GBF Braunschweig/ University of Bielefeld, IGV Berlin BergholzRehbrucke. Technological expertise: S, F, BI, BA, C/TC, CH/S, pMC Principal products/instrumentation: Biostat Laboratory, pilot and production scale fermentors

E-mail: [email protected] President/CEO: Heinz Bolli R&D expertise: Bioengineering research and manufacturing of drug sterile process components. Technological expertise: BA Principal products/instrumentation: Biologicals, specialty chemicals, food processing method, enzymes, drug sterile process components, process validation, vaccines, contract R&D products.

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299 BBS SYSTEMS, INC.

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301 BCM DEVELOPMENT, INC.

Add: 6663 Hidden Beach Circle Orlando, FL 32819

Add: 125 rue Dalhousie, Suite 218 Quebec, Quebec G1K 4C5 Canada

Tel: (407) 292-4812

Tel: (418) 692-1287

Fax: (407) 292-5306

Fax: (418) 692-6077

E-mail: [email protected]

E-mail: [email protected]

President/CEO: Heinz Bolli

President: Michel Page

R&D expertise: Development and production of stainless steel components for pharma/ biotech processing.

Research director: Michel Page

Technological expertise: BA, F Principal products/instrumentation: Stainless steel component product line used in pharma/biotechprocesslng, stainless steel components for drug processing.

300 BCM BIOTECH, INC.

R&D expertise: Development and production of paclitaxel from biotechnology, production of paclitaxel soluble derivatives. Technological expertise: P/S, H/CF, C/TC, PIS, PA Main products/instrumentation under R&D: New soluble paclitaxel derivatives, other anticancer drugs. Sealed and granted patents: Paclitaxel production process from biotechnology — USA.

Add: P.O. Box 1033 Quebec GIK 7B5 Canada Tel: (418) 692-1287 Fax: (418) 692-6077 E-mail: [email protected]

302 BCY VENTURES

President: Michel Page

Add: 160 Eglinton Ave. E, Ste. 600 Toronto, Ontario M4P 3B5 Canada

Research director: Brigitte Page

Tel: (416) 484-4666

R&D expertise: Development of on site diagnostic tests for agrifood and veterinary medicine-products for skin care.

Fax: (416) 484-6490

Joint ventures: Groupe Bio-Controle Inc. R&D collaboration: Groupe Bio-Controle Inc. Key sales market contracts: Groupe BioControle Inc. Technological expertise: P/S, H/CF, C/TC, PIS, PA Principal products/instrumentation: BioSurface; Saxi Quant. Main products/instrumentation under R&D: On-site tests for veterinary medicine diagnosis. On-site test for toxins in sea food products, onsite diagnostic for toxin.

E-mail: [email protected] Web site: www.bcyventures.com President/CEO: Lome Meikle Research director: Jamie Cherutti R&D expertise: Research of early stage biotechnology financing and management; science based development products. Joint ventures: Diamond Strategic Consultants. R&D collaboration: U of A; UBC, CBDN. Key sales market contracts: U of A; UBC, CDN. Key license and trade contracts: U of A; UBC, CDN.

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Technological expertise: AB, S Main products/instrumentation under R&D: CF Technology, preclinical; vaccines, biologicals, reagents, dextrins. Sealed and granted patents: Dextrins in CF.

Principal products/instrumentation: Flow cytometers, products for cell biology, immunology and molecular biology; Multiplexed Phosphorylation State Analysis, 2007; Fluorescent dyes for the detection of live cells and key functional activities in a variety of cell-based assays, 2002.

303 BD BIOSCIENCES Add: 7 Loveton Circle Sparks, MD 21152

305 BD BIOSCIENCES — LABWARE

Tel: (800) 638-8663 Fax: (410) 316-4906 Web site: www.bd.com/microbiology President: Deb Neff Subsidiary of Becton, Dickinson & Co. R&D expertise: Development of bacteriological culture media for production, research and quality control applications. Technological expertise: AF, E, F, PA, BS, CH/S, GA Principal products/instrumentation: BBL Select Fermentation Media; BBL Prepared Sterile Pack Plated Media for critical environments; BBL Media Ingredients and Peptones; Qualiswab QC Organisms; and BBL Crystal miniaturized identification system, Difeo Brand dehydrated culture media.

304 BD BIOSCIENCES-BIO Add: 2350 Qume Dr. San Jose, CA 95131-1807 Tel: (877) 232-8995 Fax: (408) 954-2347

Add: 2 Oak Park Bedford, MA 01730 Tel: (800) 343-2035 Fax: (800) 743-6200 E-mail: [email protected] Web site: www.bdbiosciences.com President: Debra Neff/VP Joseph Gentile Research director: Dr. Tom Collins R&D expertise: Research, development and production of biotechnology/medicine and devices. Technological expertise: BA, C/TC, F, PA, P/S, RD Principal products/instrumentation: BD Falcon Pipettes, BD Extracellular Matrix Products; BD Falcon Tubes, BD Cy-tokines & Media Additives; BD Falcon Cell Cultureware; BD BioCoat Cellware & Cell Culture Inserts, cell culture harvest. Subsidiary bodies: One Beaon Drive, Franklin Lakes, NJ 07417. Sealed and granted patents: US Patent #4,657,867; US Patent #5,731,417; US Patent #5,741,701.

Web site: www.bdbiosciences.com President: Deborah Neff Subsidiary of Becton, Dickinson & Co. R&D expertise: Development of products for life sciences, drug discovery and design, clinical diagnostics manufacture. Technological expertise: P/S, BA, H/CF, C/TC, CH/S, DD, D-D

306 BD TRANSDUCTION LABORATORIES Add: 133 Venture Ct. Lexington, KY 40511 Tel: (859) 259-1550 Fax: (859) 259-1443

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E-mail: [email protected]

Tel: (800) 742-2345

Web site: www.translab.com

Fax: (800) 643-4366

Research director: Robert Campos Gonzalez (Site Manager and VP of Research)

E-mail: [email protected]

Subsidiary of Becton Dickinson

President/CEO: John P. Wareham

R&D expertise: Research, development, manufacture and marketing of several antibodies.

R&D expertise: Development and production of automation instruments for life-science and clinical labs.

Technological expertise: C/TC, H/CF, PA, P/S Principal products/instrumentation: Monoclonal and polyclonal antibodies, antimicrosomal antibodies, cytophilic antibodies, hydrid antibodies. Sealed and granted patents: Method and Apparatus for Reacting and Washing Multiple Sample Filters, U.S. patent Number 5,108,707.

307 BEACON DIAGNOSTICS, INC. Add: 21343 Cabot Blvd. Hayward, CA 94545 Tel: (510) 782-2444 Fax: (510) 782-1951 E-mail: [email protected] President/CEO: Bert C. Del Villano, Ph.D. Research director: Bert C. Del Villano, Ph.D. R&D expertise: Research, develop, manufacture and market in vitro diagnostic reagents and test kits that utilize noninvasive specimens. R&D collaboration: University of Florida. Principal products/instrumentation: OraScreen HIV Rapid Test. Main products/instrumentation under R&D: OraScreen HB AG Rapid Test, R&D; OraScreen Analyzer, R&D; in vitro diagnostic reagents for hepatitis B.

308 BECKMAN COULTER, INC. Add: 4300 No. Harbor Blvd., P.O. Box 3100 Fullerton. CA 92834-3100

Web site: www.beckmancoulter.com

Technological expertise: D, HI, PI, P, X, Q, SM, X, V, B, O, CC, S, gN Principal products/instrumentation: DNA Sequencer, CEQ2000X6, 2000; Capillary Electrophoresis, P/ACE Systems, 1997; Centrifuges, HPLC, BiomekFX, 2000; SAGIAN Cone Systems (robotics), 2001; two new IOTest reagents, Anti-NTB-A-PE and CD226(DNAM-1)-PE, are mAbs to cell surface receptors for NK (natural killer) cell studies, 2008; Automated Viability Analyzer, 2008; new Optima MAX-XP benchtop ultracentrifuge, 2007; Dna Determination, 2007; DNA/Protein Spectrophotometer Accessory, 2007; Automated Target RNA Preparation, 2007; DNA Sequenceing Analysis, capillary electrophoresis HPLC, centrifugation, spectrophotometry, PHmeters. Subsidiary bodies: Nyon, Switzerland; Gladesville, NWS, Australia; Vienna, Austria; Mississauga, Ontario, Canada; Beijing, China; Gagny, France; Munich, Germany; Aberdeen, HongKong; Milan, Italy; Tokyo, Japan; Mijdrecht, The Netherlands; Warsaw, Poland; Johannesburg, South Africa; Bromma, Sweden, Taipei, Taiwan; Bucks, UK; Singapore.

309 BECTON DICKINSON BIOSCIENCES Add: 2350 Qume Dr. San Jose, CA 951311807 Tel: (408) 432-9475 Fax: (408) 954-2347

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Web site: www.bdfacs.com President: Deborah Neff Research director: Noel Warner Subsidiary of Becton, Dickinson R&D expertise: Development and production of cell analysis systems for research and clinical markets. Technological expertise: C/TC, PA Principal products/instrumentation: FACSCalibur Flow Cytometer; FACS Vantar Flow Cytometry System; FAC-SCount; FACStation Data Management System; Fast Immune Assay Systems; TruCount Absolute Connect Tubes; other cell analysis system. Main products/instrumentation under R&D: MultiET Software and MultiTEST reagents for automated 3- and 4-color immunophenotyping, phycoerythrin conjugates, peridinin chlorophyll protein. Sealed and granted patents: Phycoerythrin (PE) Conjugates and Allophycocyanin (APC); Peridinin Chlorophyll Protein (PerCP); simultest and IMK-Cymphocyte.

Principal products/instrumentation: China medical device market report, 1997; China Medipharm Insights (monthly), 1996; Chinese Medical News (e-mail news), 1995; influenza vaccines (Anflu), prevention influenza, 2006.

311 BEIJING DONGSIN DIGITAL TECHNOLOGY CO., LTD. Add: Km. 1606, Bldg. 3, NO. 88 jianguo Rd., Chaoyang Dist, Beijing 100022, China Tel: (86) 10-8589-2655 Fax: (86) 10-8589-2655 Web site: www.bjdongsin.com R&D expertise: R&D of automatic software of Traditional Chinese Medicines, related new products manufacture. Technological expertise: HNT, TCMM, BME Principal products/instrumentation: Automatic software for infrared diagnosis of Chinese Medicine — Automatic Thermal Analysis (ATA). Main products/instrumentation under R&D: Chinese medical device and technique. Sealed and granted patents: Automatic thermal analysis (ATA), China and the U.S.

310 BEIJING CONS BIOTECH DEVELOPMENT COMPANY Add: 9-702, An Wai Dong He Yan Beijing 100011 China Tel: (86) 10-6238-8245

312 BEIJING HEALTH FOUNTAIN SCIENCE & TECHNOLOGY CO. LTD.

Fax: (86) 10-6425-2418

Add: 40 Taiping Road, Haidian Distirict, Beijing 100039, China

E-mail: [email protected]

Tel: (86) 10-6816-1323

Web site: www.china-invest.com

Fax: (86) 10-6827-1619

President: Wang Yuquan

E-mail: [email protected]

Research director: Jay Chen

Web site: www. chinasleep.net.cn

R&D expertise: Collection of healthcare market information and marketing research.

President/CEO: Wang Xiao-dao, Professor; Deng Zhen-hua

Technological expertise: BI

Research director: Ling Rui-qin, Professor; Ma Li-ren, Professor

Key sales market contracts: Frost & Sullivan.

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R&D expertise: Medicines for aging diseases and healthy food development (manufacture), LDB low-density Biochips for clinical diagnostic purpose. Key sales market contracts: Beijing Health Fountain Biological Technology Co. Ltd Technological expertise: CS, BP Principal products/instrumentation: Sound sleep Sublingual (tablet) is taken sublingually 0.7–4.5 mg before sleep for improving sleep for clearing free radicals in brain: use 1.5–5 mg; for overcoming jet lag: After boarding on seat, use a preparing dose of 0.3–0.7 mg; before going to sleep, use 1.5–2.5 mg; for complementary regimen of cancer chemotherapy or radiotherapy, use 10–40 mg per day. Sound-sleep Sublingual is much more efficient than the oral melatonin capsule, and can correct disorders of the human biological clock and delay the process of aging: Such as mild cognitive impairment MCI so to alleviate the very early Alzheimer’s Disease AD, Senile Depression, age-related macular degeneration AMD, cataract etc. Products/instrumentation under R&D: Lowdensity biochips (LDB) for multiplex target diagnosis. LDB can detect several (up to 30 or more) targets at the same time. Our LDB technology is sensitive, accurate and economical, which can be used both in urban and rural area. The result can be within half a day (quanlitative) or 6 hour (quantitative) with printed report. Now we have accomplished the development of the LDB working-platform, that include: Spotting device (to be used by chip-manufacturer only), Hybridization device and Reading device with Software (to be used by Diagnosis personal) at very economical price acceptable to rural area.

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and technology Garden, Beijing 100070, China Tel: (86) 10-8368-1842 Fax: (86) 10-8368 1842 E-mail: [email protected] R&D expertise: A technical innovation enterprise, professional in R&D and manufacture of diagnosis device and equipment for Traditional Chinese Medical science. Technological expertise: HNT, TCMM, BME Principal products/instrumentation: SM-IA pulse diagnosis device is developed on the basis of one of the theories of Chinese traditional medicine (CTM) proposed by the famous CTM doctor Liu Shaowu and exactly simulate the feature of expert diagnosis. The device could distinguish patients’ five types of pulses accurately at the same time and provide corresponding conclusion of pulse analyzing through automatic data processing (DP); Vibratory medicine micronization disintegrator has been applied in a lot of medicine research institute and pharmacy or healthcare product enterprises. Sealed and granted patents: SM-IA Pulse diagnosis device has authorized two kinds of patent by the State Intellectual Property Office (SIPO) of China, and has been proposed one declaration of patent for invention.

314 BEL-ART PRODUCTS Add: 6 Industrial Rd. Pequannock, NJ 074401992 Tel: (973) 694-0500 Fax: (973) 694-7199 E-mail: [email protected]

313 BEIJING SMIFE SCIENCE & TECHNOLOGY DEVELOPMENT CO. LTD. Add: 1-301 Room, No. 8 Heiying Lu, Fengtai Science City, Zhongguancan science

Web site: www.bel-art.com President/CEO: David Landsberger Research director: Francis Gomes R&D expertise: Development of laboratory professional instrumentation for cell and

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tissue culture industrial and pharmaceutical product.

Tel: (32) 2-238-3462

Technological expertise: C/TC, COC, HTDS, RD, R

E-mail: [email protected]

Principal products/instrumentation: The Scienceware line of laboratory accessories: includes Precisionware leak-proof bottles, biotechnology tools including mini-tubes and 96-well blocks, safety-labeled wash bottles, pipettors, racks for every purpose and Spinbar magnetic stirring bars. Subsidiary bodies: Henderson, NC; Kansas City, MO; Pocomoke City, MD; Wayne, NJ.

315 BELDEM S.A. Add: Rue Bourrie 12 Andenne 5300 Belgium Tel: (32) 85-82-3250 Fax: (32) 85-82-3260 E-mail: [email protected] CEO: C. Renard Research director: Th. Dauvrin R&D expertise: Research, development and production of enzymes. Technological expertise: BA, E, F, GA, PMC, P/S, R Principal products/instrumentation: Xylanase, Amylase, Glucose Oxidase, Frimox, Pectinate, Frimapec, Belase. Main products/instrumentation under R&D: Pectinase, Beta Glucanase, activating enzymes, allosteric enzymes, proteolytic enzymes, restriction enzymes, transferring enzymes.

Fax: (32) 2-230-5912 Web site: www.belspo.be/bccm President: Nicole Henry Research director: Marleen Bosschaerts R&D expertise: Development of four major, research-based culture collections of bacteria, fungi, yeasts, plasmids and cDNA libraries. Contract development work include: supply of cultures, safe deposits, patent deposits, isolation, identification, molecular finger-printing & preservation of strains, screening for metabolites, sequencing, electron microscopy, material resistance testing, bio-audits, contract research, training, etc. Joint ventures: Collaborations with other culture collections and groups of excellence in a broad area of research fields. Technological expertise: AF, BI, BA, C/TC, PMC, P/S, RD Principal products/instrumentation: Circa 50,000 strains of bacteria, yeasts and fungi; circa 1,500 plasmids are readily available. Main products/instrumentation under R&D: BCCM/IHEM, Biomedical Fungi & Yeasts Collection; BCCM/MUCL (AGRO) Industrial Fungi & Yeasts Collection; BCCM/IMG Bacteria Collection; BCCM/LMBP Piasmid Collection.

317 BELLCO GLASS, INC. Add: 340 Edrudo Rd. Vineland, NT 083603493

316 BELGIAN COORDINATED COLLECTIONS OF MICROORGANISMS Add: OSTC, Rue de la Science 8 Wetenschapsstraat Brussels 1000 Belgium

Tel: (856) 691-1075 Fax: (856) 691-3247 E-mail: [email protected] Web site: www.bellcoglass.com President/CEO: Steven J. Marker

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R&D expertise: Development and production of premium glassware and equipment. Technological expertise: BA, C/TC, PMC Principal products/instrumentation: Hot shakers & hybridization ovens; Roller apparatus & incubators; Spinner flasks & overhead drive vessels; premium glassware.

318 BEN VENUE LABORATORIES, INC. Add: 300 Northfield Rd. P.O. Box 46568 Bedford, OH 44146 Tel: (216) 232-3320

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R&D expertise: Custom development Antibodies, Antibody Products and In Vivo application Studies. Technological expertise: C/TC, H/CF, PA, P/S Principal products/instrumentation: Epitopetagging, cellular marker, receptor, cytoskeletal protein, cytotoxic antibody, cell adhesion molecule transcription, factor and signal transduction receptor, cytoskeletal transcription antibodies.

320 BERLEX LABORATORIES, INC.

Fax: (216) 232-2772

Add: P.O. Box 4099 15049 San Pablo Ave. Richmond, CA 94804-0009

President: Thomas Russillo

Tel: (510) 262-5000

Research director: James Cradock

Fax: (510) 262-7095

R&D expertise: Contract development and manufacture of parenteral pharmaceuticals.

President: Dale Stringfellow, Ph.D.

Joint ventures: Cetus Ben Venue Therapeutics.

R&D expertise: Research and development of cardiovascular, oncology and immunology drugs.

Key sales market contracts: Voluntary Hospital Association (VHA), Novopharm of Canada. Technological expertise: DD Principal products/instrumentation: Generic Oncology Products, Anda Generics, parenteral nutrition pharmaceuticals, generic anticancer drug.

319 BERKELEY ANTIBODY CO. (BABCO) Add: 1223 South 47th St. Richmond, CA 94804-4609

Subsidiary of Berlex Laboratories, Inc.

Technological expertise: RD, F, P/S, BA, GA, H/CF, PMC, SY, Q, E Principal products/instrumentation: Betaseron (recombinant interferon-α-1b) for multiple sclerosis, Fludara. Main products/instrumentation under R&D: New indications for Betaseron, Betaseron (Rifbeta-1b) treat secondary prognessive multiple sclerosis, Phase III–IV, 2008; somatostatin analogs. Sealed and granted patents: Somatostatin analogs, 6,358,491, U.S.

Tel: (510) 412-8930; (800) 92-BABCO Fax: (510) 412-8940 E-mail: [email protected]

321 BERTHOLD GMBH & CO. KG

Web site: www.crpinc.com

Add: Calmbacherstr. 22 Bad Wildbad 75323 Germany

President: Tom Anderson, Ph.D.

Tel: (49) 7081-1770

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Fax: (49) 7081-177-100

323 BIACORE AB

E-mail: berthold-scienceperkinelmer.com Web site: www.berthold-online.com

Add: Rapsgatan 7 Uppsala S-75450 Sweden

Subsidiary of PerkmElmer Inc.

Tel: (46) 18-675700

R&D expertise: Research, development and production of instrumentation.

Fax: (46) 18-150110

Technological expertise: E, GA, RD, T, PA

President: Lars-Goron Andren

Principal products/instrumentation: Luminometer, Low Light Imaging System, HPLC Radio-Detector, HPLC-grade reagents, HPLCgrade solvent.

Research director: Ulf Jonsson

Web site: www.biacore.com

R&D expertise: Research, development and manufacture of analytical instruments and reagents. Technological expertise: BME, AB

322 BHI — BIOTECH HOLDINGS — GELUX, INC.

Principal products/instrumentation: BIACORE 3000, 1998; BIA-CORE 2000, BIACORE 1000, BIA-CORE X, BLACORE probe.

Add: 1556 Georgetown Rd. Hudson, OH 44236 Tel: (330) 655-5644

324 BIACORE, INC.

Fax: (330) 655-5645 E-mail: [email protected] Web site: www.biotechholdings.com President: Peter Lugojan, Ph.D. Research director: Tavaszy Ancy R&D expertise: Bioanalytical laboratory research and products manufacture. Joint ventures: LL Biores Labs, Bucharest, Romania. R&D collaboration: Crescent Chemical Corp, New York, NY. Key sales market contracts: Ward’s Natural Science, Rochester, NY. Technological expertise: E, PIS, PA, P/S Principal products/instrumentation: Gels for Electrophoresis, Geltech, 1990; Collagen Type II, Gelux, 1994; Kits for educational market, BHI; Latex protein testing. Main products/instrumentation under R&D: Ultrathin gels for diagnosis, Phase III Sealed and granted patents: US #5,543,023, (Gel Electrophoresis cassette).

Add: 200 Centennial. Ave. Suite 200 Piscataway, NJ 08854 Tel: (732) 885-5618 Fax: (732) 885-5669 Web site: www.biacore.com President: Thomas Wida R&D expertise: Development and manufacture of analytical instruments and reagents. Technological expertise: CH/S, BME Principal products/instrumentation: BIAcore, 1990; BIAlite, 1993.

325 BIDECO, LTD. Add: Im Schoerli 3 Duebendorf CH-8600 Switzerland Tel: (41) 1-824-3070 Fax: (41) 1-824-3071 E-mail: [email protected] Web site: www.bideco.com

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President: Hans-Peter Knoepfel, Ph.D.

Research director: Roger N. Piasio

Subsidiary of Bideco Holding AG

R&D expertise: Research, design, development, manufacturing and marketing of diagnostic assay.

R&D expertise: Engineering and construction research of biotech drugs and pharma facilities production. Technological expertise: RD, P/S, BA, C/TC, PMC Principal products/instrumentation: Biologicals, pharmaceuticals, diagnostics, vaccines, reagents, drug component detector.

326 BILLUPS-ROTHENBERG, INC.

Technological expertise: BA, H/CF, C/TC, PMC, CH/S Principal products/instrumentation: Glycohemaglobin, Legionella. Main products/instrumentation under R&D: Point-of-care diagnostic tests.

328 BIO ADVANCE

Add: 11555 Sorrento Valley Rd. Suite E. San Diego, CA 92014-0977

Add: Polyparc — 15, Rue Vladimir Jankelevitch Emerainville 77 184 France

Tel: (619) 755-3309

Tel: (33) 01-6461-6666

Fax: (619) 755-3455

Fax: (33) 01-6461-6220

E-mail: [email protected]

E-mail: [email protected]

President/CEO: Barry E. Rothenberg, Ph.D.

President/CEO: Claude Audiberti

Research director: Barry E. Rothenberg, Ph.D.

Research director: Dr. Jaouhari

R&D expertise: Development and production of tissue culture incubator; Hot Box system; electrophoresis devices; and radiation safety devices. Technological expertise: C/TC, GA, H/CF, Q Principal products/instrumentation: Modular Incubator Chamber; Hot Box System; Gel Electrophoreis boxes; Beta-safety shields and boxes. Sealed and granted patents: Multiple patents on tissue culture wares; Hot Box system.

R&D expertise: Research of immunology and molecular biology, relative novel products development. Technological expertise: E, PA, P/S, R Principal products/instrumentation: Autoimmunity drug, IFI, ELISA, DOT; Allergy, DOT; Instruments allergy relief medicine. Main products/instrumentation under R&D: Immunology products, preclinical; molecular biology, R&D.

329 BIOAFFINITY SYSTEMS, INC. 327 BINAX, INC.

Add: P.O. Box 818 Roscoe, IL 61073

Add: 217 Read St. Portland, ME 04103

Tel: (815) 398-1794

Tel: (207) 772-3988

Fax: (815) 398-1810

Fax: (207) 871-5751

President: Paul K. Smith

President/CEO: Roger N. Piasio

Research director: Paul K. Smith

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R&D expertise: Research, development and manufacture of biotechnology medicines.

monitor for objective quantification of laboratory animal behavior, 2007.

R&D collaboration: Northern Illinois University, Albert Einstein College of Medicine.

Subsidiary bodies: Lawrence, KS; Cheshire and Warwickshire, UK.

Technological expertise: P/S, PMC, SY Principal products/instrumentation: Biotin reagents, biological detergents (APO-10, APO-12, CHAPS), Affinity chromatography (T-GEL), crosslinking reagents, peg reagents, metal chelate reagents and supports. Main products/instrumentation under R&D: Large bead-non porous affinity media, hemoglobin modification reagents, general reagents, special reagents, affinity-isolated antibodies, affinity tag.

331 BIO-ANALYTIC LABORATORIES, INC. Add: 3473-3481 Palm CitySchoo Rd. P.O. Box 388 Palm City, FL 34990-0388 Tel: (407) 287-3340 Fax: (407) 287-3551 President/CEO: M.L. Hunter Research director: Ten Pawlik Subsidiary of C.E.G.I.

330 BIOANALYTICAL SYSTEMS, INC. Add: 2701 Kent Ave. W. Lafayette, IN 479061382 Tel: (765) 463-4527 Fax: (765) 497-1102 E-mail: [email protected]

R&D expertise: Development and manufacture of various reagents. Technological expertise: E, PA, ET Principal products/instrumentation: An expanding line of in vitro clinical chemistry diagnostics for human and veterinary science, general reagents, anti-gamma reagent.

Web site: www.bioanalytical.com President/CEO: Peter Kissinger, Ph.D. Research director: Lou Coury, Ph.D. R&D expertise: Bioanalytical purification and toxicology contract research/development services to pharmaceutical, biopharm, and medical device industries supporting clinical trials. Key license and trade contracts: Univ. of Illinois; Brookhaven National Labs; SUNY Buffalo. Technological expertise: C/TC, CC, E, P/S, R, SM Principal products/instrumentation: Liquid Chromatography; Electrochemical Analyzers; Microdialysis Sampling Devices; Raturn Awake Animal Monitoring System (1997), Cutex Automated Blood Samples (2000); Force Plate actimeter (FPA), a behavioral

332 BIOARTIFICIAL GEL TECHNOLOGIES Add: 400 Bld de Maisonneuve West Room 1156 Montreal, Quebec H3A lLA Canada Tel: (514) 280-7804 Fax: (514) 280-7805 Web site: www.bagtech.com President: Dr. Guy Fortier Research director: Dr. Guy Fortier R&D expertise: Research on drug discovery, drug design, control release and drug delivery. Technological expertise: DD, E Principal products/instrumentation: Solid cell culture medium, Microgel, 1998; Hydrogel cover slip, 1999; Cosmetic patches, Water Gel.

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Main products/instrumentation under R&D: Wound dressing for drug control release, preclinical; drug delivery devices, drug discovery route.

R&D expertise: Research, development and manufacture of polyclonal, monoclonal antibodies and kits.

Sealed and granted patents: US #5,733,563; PCT # CA94-00650.

Principal products/instrumentation: Polyclonal and monoclonal antibodies (clusters of differentiation), PNH kit (paroxysmal nocturnal hemoglobinyria), flow cytometry, polyclonal and monoclonal antibodies, diagnostic kits for flow cytometry.

333 BIO-ASSIST/BIO-ASSISTANCE Add: 553 Cr. Simonet Ile Bizard Quebec H9C 2R8 Canada Tel: (514) 620-3053 Fax: (514) 620-0865 E-mail: hennas@videotron. ca

Technological expertise: P/S, H/CF, C/TC, PA

Main products/instrumentation under R&D: A flow cytometry kit to follow engraftment in bone marrow transplantations, PNH, HbF, chimeric cells, monoclonal antibody against hepatitis B virus.

President: Hanna Sikorska, Ph.D. R&D expertise: Quality assurance program design, development and implementation for cGMP, GLP&GCP: document templates, personalized document design; process, assay, equipment validation services; audit good laboratory practice: design, documentation, implementation, audits; preclinical services outsourcing management. Technological expertise: MAE, AB, BME, C/TC, CSDP, BTC Main products/instrumentation under R&D: Murine monoclonal antibodies for the therapy and diagnosis; generation, characterization, production (parenteral cGMP), preclinical and clinical development, MAb-based radio pharmaceuticals, biotech drug.

335 BIOBASAL Add: 55 Eulerstrasse Basel 4003 Switzerland Tel: (41) 61-271-7878 Fax: (41) 61-271-83 59 E-mail: [email protected] President: Pierre Lalluette, M.D., Ph.D. Research director: Dr. P. Lallouette R&D expertise: Development and production of pharmaceuticals. R&D collaboration: Freiburg im Breisgau University. Principal products/instrumentation: Histaglobine, Leucobasal, leucomax. Subsidiary bodies: Biobasal US, 8621 C. Via Mal-lorca, La Jolla, CA 92037.

334 BIOATLANTIC Add: Hotel Dieu, Place Alexis Recordeau Nantes, Cedex 01 44093 France

336 BIOBLOCK SCIENTIFIC

Tel: (33) 02-4008-4769

Add: Parc D’Innovation Blvd. Sebastien Brant Illkirch 67450 France

Fax: (33) 02-4008-4771

Tel: (33) 88-67-1414

President: Mr. Blanchard

Fax: (33) 88-67-1125

Research director: Mr. Blanchard

President: Pierre Block

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R&D expertise: Development and manufacture of biomedical laboratory instrumentation for drug research. Technological expertise: F, P/S, BA, C/TC Principal products/instrumentation: Hoefer Scientific Instruments, YSI; drug screening instruments.

337 BIOBRAS, S.A. Add: Praca Carlos Chagas, 49, 3rd floor 3elo Horizonte, MG 30.170-020 Brazil Tel: (55) 1-31-291-9877 Fax: (55) 31-335-7988 E-mail: [email protected] Web site: www.biobras.org.br

R&D expertise: Development and production of immunotherapeutics. Key license and trade contracts: Virginia Commonwealth University. Technological expertise: D-D, PA, E, F, P/S, BI, GA, RD, G, Q, GT, HTDS, SY Main products/instrumentation under R&D: Vaccine platform, Phase I/II; Statin replacement, Phase I; Homocysteine Assay, preclinical; Inflammatory Diagnostic, preclinical; immunopotentiating agent, immunomodulator, immuno-adjuvant.

339 BIO-CARE TECHNOLOGY PTY, LTD.

President: Guilherme Emrich

Add: R.M.B. 1084 Pacific Highway Somersby, New South Wales 2250 Australia

Research director: Luciano Vilela

Tel: (61) 2-4340-2246

R&D expertise: Research, development and manufacture of biochemical products.

Fax: (61) 2-4340-2243

Technological expertise: F, P/S, BA, PMC, SY, E, DD

Web site: www.ozemail.com.au/~biocare

Principal products/instrumentation: Animal and human insulin preparations (Biohulin, Monolin, Neosulin, Iolin), insulin crystals, enzymes (Proteomix), peptones, culture media, diagnostic reagents and genetically produced insulin, insulin actrapid human.

R&D expertise: Development, manufacturing and marketing of biological products for agriculture/horticulture; formulation of microbial agents.

338 BIOCACHE PHARMACEUTICALS, LLC. Add: 800 East Leigh St. Richmond, VA 23219 Tel: (804) 827-0821 Fax: (520) 244-4326 Web site: www.biocache.com President: Timothy P. Coleman, Ph.D. Research director: Jeff Slunt, Ph.D.

E-mail: [email protected] Research director: G. Bullard or D. Pulsford

Joint ventures: Department of Primary Industries, Tasmania-fungal insecticide; BSES/ SRDC/CSIRO, fungal infective. R&D collaboration: University of Queensland — develop a microbial control agent for hay fodder preservation. Key license and trade contracts: BSES/ SRDC/CSIRO, Tasmania DPI, Lumines (Univ. of Adelaide). Technological expertise: F, FE Principal products/instrumentation: Nodulaid, Nitrogerm legume inoculants; NOGALL biological control agent against crown gall disease. BioGreen Granules, a

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fungal insecticide to control pasture beetle grubs, BioCane Granules — Funga Insecticide to control greyback cane grubs in sugarcane; Trich-a-Soil Trichoderrna inoculant for turf. Main products/instrumentation under R&D: ExiTerm, HayRite, microbial control agent for hay fodder preservation.

340 BIOCATALYSTS, LTD. Add: Treforest Industrial Estate Pontypridd, Wales CF37 5UD UK Tel: (44) 0-1443-843712 Fax: (44) 0-1443-846500 E-mail: [email protected] Web site: www.biocatalysts.com President: W. G. Salisbury Research director: Dr. Philip Cunnah R&D expertise: Development and production of enzymes. Technological expertise: C/TC, CH/S, E, F, P/S Principal products/instrumentation: Leucine dehydrogenase, glutamate dehydrogenase phenylalanine dehydrogenase, dehydrogenase, lipoxygenase, restriction enzymes, catheptic enzymes.

107

R&D expertise: Development, production and applications of enzymes for chemical synthesis and diagnostics; biocatalysis; production of chiral intermediates. Key license and trade contracts: Degussa AG; EnzyMed Corp.; Genetics Institute, Inc. Technological expertise: BA, S, CC, E, PIS, RD, SMC, SY Principal products/instrumentation: Transaminase-broad range, 1997; Transaminasebranched chain, 1997; Non-natural amino acid production, 1997; Cystine assay, Homocysteine assay, 1998; Production of amino alcohols. Main products/instrumentation under R&D: Production of 1, 2 Amino alcohols; production of 1, 3 Amino alcohols; production of 1, 4 Amino alcohols; Neonatal Screen: Homocysteine. Sealed and granted patents: 4,518,692; 4,525,454; 4,826,766; 4,880,738; 5,834,261; 5,885,767, and 5,916,786.

342 BIOCELL LABORATORIES, INC. Add: 2001 University Dominguez, CA 90220

Ave.

Rancho

Tel: (800) 222-8382 Fax: (310) 637-3927 E-mail: [email protected]

341 BIOCATALYTICS, INC. Add: 39 Congress Street Ste. 303 Pasadena, CA 91105 Tel: (818) 841-0072 Fax: (818) 841-0011 E-mail: [email protected] Web site: www.biocatalytics.com President/CEO: J. David Rozzell Research director: J. David Rozzell

Web site: www.biocell.com President/CEO: Marc M. McKonic Research director: C. Sisowath R&D expertise: Development of cell culture nutrients, sera & sera fractions, IVD controls calibrators and chemistry immunology. Technological expertise: C/TC, CC, COC, P/S Principal products/instrumentation: Animal and human sera, including FBS and human serum type AB; serum fractions and concentrates:

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albumins, globulins, lipids (HDL/LDL/ Apo-Lipoproteins); specialty sera: hormone stripped, delipidized and analyte adjusted; human and animal sera-based controls and calibrators, single and multi-analyte; contract manufacturing products, Biolipid (95), Biourine (95).

343 BIOCHECK LAB CO. Add: 10F, 8,348 Lane, Sec. 2, Chung-Shan Rd. Chung-Ho, Taipei 235 Taiwan Tel: (886) 2-2246-7799

Main products/instrumentation under R&D: Biologicals, antibiotics, various recombinant proeins. Subsidiary bodies: Biochemie S.p.a, Rovereto, Italv, Biochemie S.A., Les Franqueses, Spain; Novartis Biochemie Indonesia, Jakarta, Indonesia; Biochemie Plant Schaftenau, Austria; Grandis Biotech, Germany; Biochemie Frankfurt, Germany.

345 BIOCHEM PHARMA, INC.

Fax: (886) 2-2247-1188

Add: 275 Armand-Frappier Blvd. Laval, Quebec H7V 4A7 Canada

E-mail: [email protected]

Tel: (450) 681-1744

President/CEO: Dennis Chen

Fax: (450) 978-7755

Technological expertise: AB, BA, C/TC, GA, G, HTDS, PA, PIS, P/S, RD, R, SY, Q, T

E-mail: [email protected]

Principal products/instrumentation: Abbott/ Murex, Qiagen Instrument, Hyclone, Pall/ Gelman, Greiner, biogenex, Thinprep, Dygene, Evergreen, Porex, Biotrace, Biotest, biomaterials, diagnostics, vaccines.

President: Jacques Lapointe

344 BIOCHEMIE GMBH Add: Biochemiestrasse 10 Kundl A-6250 Austria Tel: (43) 5338-200-680 Fax: (43) 5338-200-442 E-mail: com

[email protected].

Web site: www.biochemie.com President: Dr. Heinrich Scherfler Research director: Dr. E. Leitner Subsidiary of Novartis R&D expertise: Research and development of antiinfectives, recombinant proteins. Technological expertise: F, P/S, RD, LP, BA, large-scale microbial fermentation.

Web site: www.biochempharma.com Research director: Dr. Gervais Dionne R&D expertise: Research, development and production of innovative biopharmaceutical for infectious diseases and cancer. R&D collaboration: Glaxo Wellcome, SmithKline Beecham, AstraZeneca. Contract of market sell: Glaxo Wellcome, SmithKline Beecham. Key license and trade contracts: Maxim Pharmaceuticals, Cytovax Biotechnologies. Technological expertise: F, SMC, P/S, HTDS, PIS, P/S, BI, BA, C/TC, COC, DD, D-D Principal products/instrumentation: Lamivudine for HIV/AIDS, 3TC/Epivir 1995; Lamivudine for chronic hepatitis B, Zeffix/ Heptovir/Epivir-HBV Heptodin, 1998; Pacis for bladder cancer. Main products/instrumentation under R&D: Troxatyl (troxacitabine) for cancer; (-)dOTC for HMAIDS; BCH-3963/LEF for pain control; BCH-13520 for HIV/AIDS; luviral S/F; Injectable cell-culture for influenza; Nasal

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cell-culture for influenza; Neisseria meningitidis; Group B Streptococcus vaccines; Pseudomonas aeruginosa. Subsidiary bodies: Vaccine Development, 30 Bearfoot Road, Northborough, MA 01532, USA, 508/351-9944; Vaccine Production, 2323 du Parc Technologique Blvd., Sainte-Foy, Quebec G1P 4R8, Canada, 418/650-0010. Sealed and granted patents: BioChem currently has 21 issued patents in the U.S. claiming nucleoside analogs, methods of treatment using nucleoside analogs and processes for producing these nucleoside analogs. These patents include claims covering the chemical composition of lamivudine, troxacitabine, dOTC and related nucleoside analogs and methods of treating viral infections, including HIV and hepatitis B, with lamivudine and related nucleoside analogs. The company also has issued patents and pending applications covering lamivudine, troxacitabine, dOTC or other nucleoside analogs, processes for their preparation and methods of using same, in over 100 countries, including issue patents or pending applications in the U.S., most European countries, Japan, Australia and Canada.

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347 BIO-CHEM VALVE, INC. Add: 85 Fulton St. Boonton, NT 07005 Tel: (973) 263-3001 Fax: (973) 263-2880 Web site: www.bio-chemvalve.com President: Adam Meyers Subsidiary of Haima PLC R&D expertise: Manufacture of miniature inert solenoid operated valves and pumps. Technological expertise: BME Principal products/instrumentation: Inert solenoid operated valves and pumps, custom manifold configurations.

348 BIOCHROM KG Add: Leonorenstr. 2-6 Berlin 12247 Germany Tel: (49) 30-779-9060 Fax: (49) 30-771-0012 E-mail: [email protected] President/CEO: Dr. Bernd Frenzel R&D expertise: Research, development and production of biotechnology medicines.

346 BIOCHEM TECHNOLOGY, INC. Add: 100 Ross Rd., Ste. 201 King of Prussia, PA 19406 Tel: (610) 768-9360 Fax: (610) 768-9360

Technological expertise: C/TC, BS, GM, COS Principal products/instrumentation: Sera, media, additive solutions for defined cell culture, serum-free media, antisera, diagnostics. Customized media cell culture products.

President: George Jaw Fang Lee Research director: Sergey mane shin R&D expertise: Wastewater treatment research and products development. Technological expertise: FE, ERT, LC/TC, BA, RDS, F, PMC, CH/S Principal products/instrumentation: The BioGuide System for activated sludge management.

349 BIOCHROM KG Add: Leonorenser. 2-6 Berlin 12247 Germany Tel: (49) 30-779-900600 Fax: (49) 30-77-0012 E-mail: [email protected] Web site: www.biochrom.de

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President: Dr. Bernd Frenzel

Fax: (54) 11-4942-0988

Research director: Ruediger Frenzel

E-mail: [email protected]

R&D expertise: Development and manufacture of many products for bioprocess, bioprocessing engineering cell and tissue culture.

Web site: www.biocientifica.com.ar

Key sales market contracts: Merck, euro lab (cell culture products). Technological expertise: C/TC, TE, LC/TC Principal products/instrumentation: Animal sera, cell media, cell/tissue culture products, bioprocessing engineering products.

350 BIOCHROM LABS, INC. Add: 1719 South 13th St. Terre Haute, IN 47802

President: Roberto Sedlinsky R&D expertise: Research and development of in vitro diagnostics, immunology, autoimmunity, infectious diseases, and proteins relative production manufacture. Technological expertise: E, PA, BI, BS, C/TC, CH/S, H/CF, P/S Principal products/instrumentation: IFA kits for infectious diseases, Immunofluor; IFA kits for autoimmunity, Immunofluor; Rid Plates for proteins, Diffu-plate. Main products/instrumentation under R&D: Turbidimetric Assay, Phase II; turbidimeter

Tel: (812) 234-2558 Fax: (812) 234-2461

352 BIOCLEAR

E-mail: [email protected] Web site: www.biochroml.com President/CEO: Michael J. Lu Research director: Peter Chang R&D expertise: Development and production of polymeric packing materials. Technological expertise: BA, PIS, P/S, SY Principal products/instrumentation: HYDROCELL polymeric HPLC columns and packing materials for biomolecule separation including ion exchange, hydrophobic interaction, reversed phase and high speed nucleic acid columns. Main products/instrumentation under R&D: Polymeric beads, Biocom-Coat, polymeric membrane, polymeric surface-active agent.

Add: Zernikepark 6d Groningen NL-9797 AN Netherlands Tel: (31) 13-1505-718455 Fax: (31) 13-1505-717920 E-mail: [email protected] President: S. Keuning Research director: J. v. d. Waarde R&D expertise: Research of environmental biotechnology and products development. Technological expertise: BA, BI Principal products/instrumentation: Custom Research products & consulting. Main products/instrumentation under R&D: Quantitative PCR detection, environmental pollutant detector, environmental bioremediation.

351 BIOCIENTIFICA S.A. Add: Avenue San Juan 2631 Buenos Aires 1232 Argentina Tel: (54) 11-494-23654

353 BIOCLINICAL PARTNERS, INC. Add: 25 Kenwood Circle Ste. 14 A Franklin, MA 02038

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Tel: (508) 520-0588 Fax: (508) 520-1525 President/CEO: Steven R. Raia R&D expertise: Drug clinical trials and access to patient relations for diagnostic test research and relative product development.

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no. 91122041.6; U.S. 5,777,074; 6,008,044/ 6,083,504 European application no. 00102215.1. Publication number 1016671.

355 BIOCODE, INC.

Technological expertise: SMC

Add: 115 Research Dr. Bethlehem, PA 18015

Principal products/instrumentation: Archives of clinically defined patient sera for tumor marker, endocrinology, autoimmune and infectious disease research and product development.

Tel: (610) 861-6965 Fax: (610) 861-6968 Web site: www.biocode.com President/CEG: John Davies

354 BIOCLONETICS, INC. Add: 921 South 8th St. Philadelphia, PA 19147 Tel: (215) 592-9988 Fax: (305) 832-0519

Research director: Jim Rittenburg, Ph.D. R&D expertise: Research and development of product identification, authentication using antibody pairs. R&D collaboration: Strategic diagnostics Inc.

E-mail: [email protected]

Contract unit of market: Oronite Division of Chevron.

Web site: www.bioclonetics.com

Technological expertise: F, PM, C/TC, H/CF

President: Joseph Cotropia, M.D.

Principal products/instrumentation: Securijet® inline ink jet printing of invisible barcodes on containers and packaging. Securiprint® printing of uniform invisible codes on labels, marker binding pair.

Research director: Joseph Cotropia, M.D. R&D expertise: Research, development and production of diagnostic and therapeutic human monoclonal anti-HIV-1 antibodies. R&D collaboration: University of Pennsylvania; University of California, San Francisco; Karolinska Institutet, Stockholm, Sweden; Public Health Research Institute, NY; INSERM, Marseille, France; Jikei University School of Medicine, Tokyo, Japan; Nissin Food Products Co., LTD; Nissin Central Research Inst. Shiga, 525 Japan Kusatsu City; University of South Florida; Instituto de Investiga-ciones Biomedicas Universidad Nacional Autonoma de Mexico. Technological expertise: H/CF, C/TC, AB Main products/instrumentation under R&D: Diagnostic and therapeutic human monoclonal anti-HIV-1 antibodies, preclinical studies. Sealed and granted patents: 07/633,964; U.S. 5,459,060; Euro-pean patent application,

Subsidiary bodies: York, UK. Sealed and granted patents: Use of binding pairs to detect markers intentionally added to products for identification.

356 BIOCON, INC. Add: 15801 Crabbs Branch Way Rockville, MD 20855 Tel: (301) 417-0585 Fax: (301) 417-9238 E-mail: [email protected] Web site: www.bioconinc.com President: Lawrence E. Cunnick Research director: Stephen Harshman

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R&D expertise: Research, development and supply of animal related products and services to the biotechnoiogy/biomedical marketplace.

President: Emilio Rachera-Guillem, M.D., Ph.D.

Technological expertise: PA, T, C/TC, H/CF, LP, PMC, Transgenic/knockout breeding, biopharmaceutical testing, uniquely designed animal studies.

R&D expertise: Development and production of novel biomedical devices and techniques for the detection and diagnosis of various diseases.

Principal products/instrumentation: Monoclonal antibodies and polyclonal antibodies. Custom antibodies, and transgenic breeding animal, knockout breeding animal.

357 BIO-CONSULT Add: Marburger St. 14 Berlin D-10789 Germany Tel: (49) 219-680-9230 Fax: (49) 219-680-9230 President/CEO: Dr. W. H. Stroh Subsidiary of BC-International R&D expertise: Research of European consultancy specializing in the genetic engineering technologies market research reports. R&D collaboration: Major European and U.S. university institutes, with partnerships in Asia Pacific. Technological expertise: E, AF, TE, AB, DD, RD, GT Principal products/instrumentation: Biologicals, cosmetics, nutraceuticals, pharmaceuticals, genetic engineering technologies market research reports.

358 BIOCRYSTAL, LTD.

Research director: Dr. Barbera-Guillem

Key license and trade contracts: M.I.T. (fluorescent Nan crystals). Technological expertise: C/TC, D-D, HTDS, P/S, RD, SMC, BME Principal products/instrumentation: Disposable cell culture device, a comprehensive cell management tool, OptiCell™, 4th quarter 2000. Main products/instrumentation under R&D: BioPixels™ nanocrystalline fluorescent markers, (in pre-market evaluations); Cancer therapyBcell depletion (Preclinical); cell culture apparatus, automated. Sealed and granted patents: Polynucleotides for inhibiting metastasis and cell growth. 6,268,350, U.S.; Functionalized encapsulate fluorescent nanocrystals. 7,060,252, U.S.; Cell culture apparatus and methods of use. 6,821,772, U.S.; compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response. 6,762,032, U.S.; Automated cell management system for growth and manipulation of cultured cells. 6,673,595, U.S.; other patents pending.

359 BIOCRYST PHARMACEUTICALS, INC. Add: 2190 Parkway Lake Dr. Birmingham, AL 35244

Add: 575 McCorkle Blvd. Westerviile, OH 43082

Tel: (205) 444-4600

Tel: (614) 818-1170

CEO: Charles E. Bugg, Ph.D.

Fax: (614) 818-1615

Research director: John A. Montgomery, Ph.D.

Web site: www.biocrystal.com

Fax: (205) 444-4640

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R&D expertise: Drug design research for discovery, development of several small molecule therapeutics for autoimmune and inflammatory diseases.

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and pending (2001); Hydro gel-isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules. 6,592,894, U.S.

R&D collaboration: Ciba-Geigy. Key license and trade contracts: Ciba-Geigy. Technological expertise: RD, P/S, DDI, D-D Main products/instrumentation under R&D: Purine nucleoside phosphorylase inhibitors; BCX-22 transplant rejection, pre-clinical; BCX-34 proliferative T-cell skin diseases, clinical; influenza neuraminidase inhibitors; Factor D inhibitors, drug discovery; other small molecule therapeutics.

360 BIODELIVERY SCIENCES, INC. Add: 42 Buckman Dr. Lexington, MA 021736040 Tel: (617) 863-0305 Fax: (617) 862-3533 CEO: Irving A. Berstein, Ph.D. Research director: Raphael Mannrno, Ph.D. R&D expertise: Research and development of proprietary delivery technology for drugs, genes, vaccines, antisense, antifungal agents, nutrients for human & animal health products. R&D collaboration: Wyeth-Lederle Division of American Home Products, Inc. for use of cochleates in human vaccines Technological expertise: AF, AB, DD, GT, AS, G Main products/instrumentation under R&D: Phase II trial of Bioral Amphotericin B, its antifungal agent, 2009.

361 BIODESIGN, INC. OF NEW YORK Add: P.O. Box 1050 Carmel, NY 10512 Tel: (845) 454-6610 Fax: (845) 454-6077 E-mail: [email protected] Web site: www.biodesignofny.com President/CEO: Michael Ross, Ph.D. R&D expertise: Development and manufacture of innovative bioproducts in the cell biology and biochemistry areas. Key sales market contracts: Asia Distributor: Nacalai Tesque, Inc., Kyoto, Japan; England, Ireland, Scotland: BDH- Merck, Leicestershire. Technological expertise: P/S, BA, H/CF, C/TC Principal products/instrumentation: BioDesign Gel Wrap™, a unique membrane based method to preserve polyacrylainide and agarose gels; CellMicroSieve™ nylon filter matrix for isolate cells, organelles or remove cellular derivative; BioDesign Dialysis Tubing™, professional dialysis tubing specifically made for the biomedical researcher, and many other new products. Main products/instrumentation under R&D: Several new innovative products in the areas of filtration and immunoassay analysis will shortly be marketed.

R&D expertise: principal products/instrumentation and Main products oral and intranasal delivery of drugs, genes, vaccines, antisense, antifungal agents for humans and animals; delivery route of biologically relevant molecules.

Add: 60 Industrial Park Rd. Saco, ME 04072

Sealed and granted patents: A substantial number of U.S. and foreign patents awarded,

Tel: (888) 530-0140; (207) 283-6500, 9856322

362 BIODESIGN INTERNATIONAL

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Fax: (207) 283-4800, 985-

Fax: (310) 966-9346

E-mail: [email protected]

E-mail: [email protected]

Web site: www.biodesign.com

Web site: www.biodiscovery.com

President: Linda Diou

President: Soheil Shams, Ph.D.

Subsidiary of Meridian Diagnostics

Research director: S. Shams, Ph.D., Bruce Hoff, Ph.D.

R&D expertise: Development and production of antibodies and antigens for industry and drug research. Technological expertise: BA, C/TC, PA, P/S, PMC, LP, monoclonal Ab, purified biologicals. Principal products/instrumentation: Biologicals, contract manufacturing products, diagnostics, instrumentation, reagents, vaccines, veterinary products, monoclonal antibodies, polyclonal antibodies, purified protein derivative, purified insulin, specia chemicals.

363 BIODIGM, LTD. Add: New Millennium House 16 The BanksBingham, Notts NG13 8BL UK

R&D expertise: Research of DNA microarray bioinformatics software applications, bioinformatics services and consulting. Technological expertise: BI, CH/S, G, PG Principal products/instrumentation: Completely automated system for microarray image analysis; various modules for membrane and glass cDNA arrays; microarray data mining tools; microarray experiment databasing and virtual design software packages; customdesigned microarray databases. Main products/instrumentation under R&D: Advanced interactive microarray databases, analysis and navigation tools, DNA microarray bioinformatics software.

Tel: (44) 1-949-876-156 Fax: (44) 1-949-876-156 E-mail: [email protected] Web site: www.biodigm.com President/CEO: Dr. Michael J. Geisow R&D expertise: Develop and provide biotechnology information and marketing. Technological expertise: BI, CH/S Principal products/instrumentation: Structural Biology Industry Platform (www.biodigm.com/ science), Phoretix (www.phorefix.org), biotechnology information/marketing reports.

364 BIODISCOVERY, INC. Add: 11150 W. Olympic Blvd. Ste. 1170 Los Angeles, CA 90064 Tel: (310) 966-9366

365 BIODOT, INC. Add: 17781 Sky Park Circle Irvine, CA 92614 Tel: (714) 440-3685 Fax: (714) 440-3694 E-mail: [email protected] Web site: www.biodot.com President: Mike L. Surmanian Research director: Tom Tisone R&D expertise: Research, development and manufacture of equipment for rapid biodiagnostic tests, and of precision liquid handling for drug discovery. Principal products/instrumentation: XYZ Dispensing Platform, Aspirate & Dispense Platform, Biojet Quanti Dispenser, Airfet Dispenser, Cutting Module Guillotine, Table Larninator, Reel-to-Reel Platform.

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Main products/instrumentation under R&D: Rapid bio-dignostic test devices.

Key sales market contracts: Safepharm Laboratories, LC Biosciences.

Sealed and granted patents: Precision Metered Solenoid Valve Dispenser, #5,743,960; Method of dispensing a liquid, #5,741,554; Precision Metered Aerosol Dispensing Apparatus, #5,738,728; other patents are pending.

Technological expertise: CC, P/S, SY, SM

366 BIODRUG TECHNOLOGY Add: 400 Friel #9 Ottawa, Ontario KIN 7N6 Canada Tel: (613) 231-7679 E-mail: www.biodrugtechnology.com President: Wendy Apple Baum R&D expertise: Development of biodrug technology information.

Principal products/instrumentation: Biologicals, specialty chemicals, contract manufacturing products, peptides, contract research/ trial products, pesticides, pharmaceuticals, vaccines, antibodies, reagents, drug metabolic enzymes.

368 BIOE, INC. Add: 4280 Centerville Rd. St. Paul, MN 55127 Tel: (800) 350-6466 E-mail: [email protected] Web site: www.bioe.com

Technological expertise: BI, PMC

President/CEO: David Shaut

Principal products/instrumentation: An electronic portal containing all information pertaining to biotechnology includes: biodrug technology corporate profiles, investor information.

Research director: Dan Collins

Subsidiary bodies: Journal/Resource information; Terminology/Glossary items; Development by country; Resources for just about everything related to the field.

367 BIODYNAMICS Add: Walton Manor Walton Milton Keynes MK7 7AJ UK Tel: (44) 0 1908-201-653 Fax: (44) 0 1908-201-654 E-mail: [email protected] Web site: www.biodynamics.co.uk

R&D expertise: Research and manufacture of cytokine immunoassays, cellular controls, sample preparation reagents, infectious disease diagnosis relative products. Technological expertise: PG, PA, PMC Principal products/instrumentation: Multiplex cytokine immunoassays, Multiflow, 1999; Cytokine immunoassays, Immuno Flow; Intracellular cytokine immunoassays, QuantiCyte; Sample preparation reagents, BioPrep. Main products/instrumentation under R&D: Infectious Disease Diagnostic, Preclinical; sample preparation reagents, cell separation composition. Sealed and granted patents: Cell separation compositions and methods, 7,106,723, U.S.

CEO: Stephen Liwinton Research director: Stephen Lewinton R&D expertise: R&D and contract services manufacture of pharmaceutical industry areas including drug metabolism, bioanalysis, synthetic chemistry, radiosynthesis, etc.

369 BIOENERGY, INC. Add: 13840 Johnson St. RE. Minneapolis, MN 55304

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Tel: (763) 757-0032

Tel: (757) 423-8826

Fax: (763) 757-0588

Fax: (757) 423-2065

E-mail: [email protected]

E-mail: [email protected]

Web site: www.ribose.com

Web site: www.wilbio.com

President/CEO: Clarence A. Johnson

President: Keith L. Carson

Research director: David Hogsett

Research director: Lloyd Wolfinbarger, Jr., Ph.D.

R&D expertise: Development and production of D-Ribose. Technological expertise: BA, O, F, P/S, SMC Principal products/instrumentation: D-Ribose Powder, Bioenergy Ribose. Main products/instrumentation under R&D: D-ribosomal protein, D-ribosomal RNA.

370 BIOENGINEERING AG Add: Sagenrainstrasse 7 Wald, ZH 8636 Switzerland Tel: (41) 55-256-8111 Fax: (41) 55-256-8256 E-mail: [email protected] President: Pio Meyer R&D expertise: Research, development and production of biomedical equipment. Technological expertise: BA, C/TC, CH/S, F, SI, BME, design & production of microbiological plant. Principal products/instrumentation: Fermenters and reactors for laboratory 1L volume to production plant 100,000L volume; stirred tanks; airlift; dialyse reactors; pathogenic plants; microbiological plants; sterilization facilities; CIP; sterile pressure vessel; process control; spiral filter system; cell retention system; mixers-stirrer, bioreactor-control software, valves, bio-equipment.

371 BIOENHANCE (DIVISION OF CARSON BIOSYSTEMS, INC.) Add: 4015 Killam Ave. Norfolk, VA 23508

R&D expertise: Contract research, development & production of mammalian cell derived products. R&D collaboration: Virginia’s Center for Innovative Technology, Old Dominion University. Technological expertise: CH/S, H/CF, PMC, P/S, C/TC, LP, BA, contract production and development, technology transfer, purification methods development. Principal products/instrumentation: Biologicals, contract manufacturing products, diagnostics, instrumentation, process validation, reagents, vaccines, and veterinary products contract R&D products, technology transfer bioproducts, mammalian cell derived products.

372 BIOERGONOMICS (BIOE) Add: 4280 Centerville Rd. St. Paul, MN 55424 Tel: (651) 426-6466 Fax: (651) 426-5740 E-mail: [email protected] Web site: www.bioe.com President: David Shaut Research director: Dan Collins R&D expertise: Development and production of clinical research diagnostics and reagents. Technological expertise: C/TC Principal products/instrumentation: Quant Flow Immunoassays; Multi Flow IFA; FluoroTrol Controls.

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Main products/instrumentation under R&D: Cell separation composition and methods. Sealed and granted patents: Cell separation compositions and methods, 6,933,148, U.S.

373 BIO-EX MEDICA Add: 200 E. 90th St. Suite 23A New York, NY 10128

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Principal products/instrumentation: Enzymes, reagents, vaccines, antibodies.

375 BIOFLUIDS DIVISION, BIOSOURCE INTERNATIONAL, INC. Add: 1114 Taft St. Rockville, MD 20850 Tel: (301) 424-4140; (800) 972-5200

Tel: (212) 348-1981

Fax: (301) 424-3619

President/CEO: Brandon J. Melloy

E-mail: [email protected]

Research director: Harry Nabisco

Web site: www.biofluids.com

R&D expertise: Development and production of hormones and several enzymes that inhibit or prevent aging process.

President: David Androphy (General Manager)

Technological expertise: RD, P/S, C/TC, E, D-D

R&D expertise: Development and production of sterile biological fluids and animal sera including fetal bovine serum.

Principal products/instrumentation: Biological, hormones. Main products/instrumentation under R&D: Enzymes for preventing aging process, antiaging enzymes.

374 BIOFACTOR GMBH PHARMACEUTICAL IMPORT-EXPORT Add: Rudolf-Huch-Str. Harzburg Germany

14

38667

Bad

Tel: (49) 0 5322-960514 Fax: (49) 0 5322-93017 E-mail: [email protected]

Research director: David Androphy Subsidiary of Biosource International Inc.

Key license and trade contracts: Nestle Ltd.; Vevey, Switzerland. Technological expertise: C/TC, AF Principal products/instrumentation: Fetal bovine serum, cell culture media, biological reagents, serum-free cell culture media, custom media preparation, molecular biology fluids for specialized cells, buffers, other animal sera, reagents & molecular cloning products, interferon and mycoplasma assays. Main products/instrumentation under R&D: Serum-free media. Subsidiary bodies: Biosource International Inc., Camarillo, CA.

Web site: www.biofactor.de President: Milan C. Pesic, M.D.

376 BIOFOCUS

Research director: Dr. Jan. Czarnecki R&D expertise: Import and export of biopharmaceutical products; contract manufacturing (outsourcing).

Add: Sittingbourne Research Centre Sittingbourne, Kent ME9 8AZ UK

Technological expertise: LP, E, P/S, DD

Fax: (44) 1-795-471123

Tel: (44) 1-795-412300

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E-mail: [email protected]

Tel: (49) 214-876320

Web site: www.biofocus.com

Fax: (49) 214-8763290

CEO: Dr. David Stone

E-mail: [email protected]

R&D expertise: Research of medicinal, computational and combinational chemistry, related novel technologies development.

Web site: www.biofrontera.com

R&D collaboration: Roche Discovery Welwyn (UK); Viropharma, Inc. (US); Scriptgen, Inc. (US); Cubist, Inc. (US); Prolifix Ltd. (UK); Parke-Davis (UK), Phamaca & Upjohn (Sweden); Aventis Cropscience Boehringer Ingelhelm. Technological expertise: BI, COC, CH/S, D-D, P/S, R, SMC, SY Principal products/instrumentation: Screening libraries; Chemistry services for novel drug discovery. 377 BIOFORCE LABORATORY, INC. Add: 2901 South Loop Dr. Ames, IA 50010

CEO: Prof Hermann Luebbert R&D expertise: Research and development of gene expression profiling, discovery of new targets and drugs for CNS diseases. R&D collaboration: Pharm-ECO Laboratories, Inc., Lexington, MA, USA. Technological expertise: T, BI, G Main products/instrumentation under R&D: Gene expression profiling, therapeutics for CNS diseases, mRNA molecules. Sealed and granted patents: Digital Expression Pattern Display (DEPD); Methods for characterizing mRNA molecules, 6,670,121, U.S.

379 BIOFX LABORATORIES

Tel: (515) 296-6550 E-mail: [email protected]

Add: 9633 Liberty Rd. Ste. S. Randallstown, MD 21133

Web site: www.bioforcelab.com

Tel: (410) 496-6006

President: Dr. Eric Henderson

Fax: (410) 496-6008

Research director: Dr. Curtis Mosher

E-mail: biofx@biofxcom

R&D expertise: Atomic force microscope (AFM) R&D and products manufacture.

Web site: www.biofx.com

Technological expertise: G, Q

Research director: Thomas Woerner

Principal products/instrumentation: Customized AFM probes; AFM-oriented peripheral products.

R&D expertise: Research, development and manufacture of immuno-substrates and reagents.

Main products/instrumentation under R&D: Solid-state genome mapping technology; High throughput molecular screening methods, proteomics.

Principal products/instrumentation: TMB Microwell & Membrane substrate; BCIP Microwell & Membrane substrate; PNPP Microwell substrate; immunodiagnostic reagents.

Fax: (515) 296-6570

378 BIOFRONTERA PHARMACEUTICALS GMBH Add: Hemmelrather Weg 201 Leverkusen D-51377 Germany

President: Stephen C. Mefferd

Technological expertise: C/TC, CH/S, PMC, TE

380 BIOGAIA FERMENTATION AB Add: Box 965 Lund S-220 09 Sweden Tel: (46) 46-280-1700

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382 BIO/GENE, LTD.

E-mail: [email protected] President: Dr. Harald Skogman

Add: 6 The Business Centre Harvard Way Kimbolton, Cambs PE28 ONJ UK

Research director: Dr. AnnCatrin Berg

Tel: (44) 0 1480-861831

Subsidiary of Biogaia Biologics AB

Fax: (44) 0 1480-861899

R&D expertise: Contract development and manufacture of fermentation products for pharmaceutical and biotechnology industry.

E-mail: [email protected]

Technological expertise: F, P/S

R&D expertise: Development and manufacture of molecular biology equipment and consumables.

Web site: www.biogaia.se

Main products/instrumentation under R&D: Veterinary vaccines, fine chemicals, specialty chemicals, fermentor, fermentograph, fermentor control devices. Subsidiary bodies: Stavanger, Norway.

381 BIOGENE INDIA Add: E/38 Moti Nagar New Delhi 110015 India Tel: (91) 11-545-1426

Web site: www.biogene.co.uk President: N. Nazareth

Key sales market contracts: Idaho Technology Inc.; Genhunter Corp.; DNArnp. Technological expertise: AB, C/TC, CH/S, GA, GT, HTDS, P/S, RD, R Principal products/instrumentation: Thermal Cyclers, Real Time Quantitative PCR Machines, Nucleic Acid Purification Systems, Reagents for Molecular Biology, Agaroses, Media, Gel Documentation Systems; Bio/Logic reasoning, Biobotic Systems for gridding and arraying.

Fax: (91) 11-545-0538 E-mail: [email protected] Web site: www.biogene-india.com

383 BIOGENESIS, LTD.

President: Sanjay Makhija

Add: Technology Road Poole BH17 7DA UK

R&D expertise: Drug products development of life science research.

Tel: (44) 1202-660006

Technological expertise: CSDP, PA

E-mail: [email protected]

Joint ventures: AMRESCO, NEN Lifesciences, Falcon (Becton Dickinson).

Web site: www.biogenesis.co.uk

Key sales market contracts: AMRESCO, NEN, Falcon (Becton Dickinson).

Research director: Alan Tunnicliffe, Ph.D.

Principal products/instrumentation: Ultrapure chemicals, AMRESCO, 1994; radioactive products, NEN Life Science, 1996; Plasticware (tissue culture), Falcon, 1997; Tysabri (Natalizumab) for treatment of patients with relapsing forms of multiple sclerosis (MS) to reduce the frequency of clinical exacerbations, 2004.

Fax: (44) 1202-660020

President/CEO: John Coward R&D expertise: Development of manufacture and immunoreagents for research and diagnostic applications. Technological expertise: C/TC, H/CF, PIS, PA, P/S Principal products/instrumentation: Biologicals, contract manufacturing products, immunoreagents, vaccines, antibodies.

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Subsidiary bodies: Biogenesis Inc., 180 Rte. 125, Brenwood, NH 03833, Tel: (603) 6428302, Fax: (603) 642-8322, subsidiary of Biogenesis Ltd.

384 BIOGENETICA MEXICANA Add: Gonzalez de Cosio #22-401 Apartado Postal 43 Cuidad Hidalgo, Michoacan 06100 Mexico Tel: (52) 715-40863

Principal products/instrumentation: Automated antigen retrieval i1000, 2000; Automated immunostaining system, i6000, 2000; Consolidated Staining System, Optimax, 1996; Digital Image Analysis System, iVision, 2000. Sealed and granted patents: Antigen Retrieval; Automated Staining Apparatus.

386 BIOGEN, INC.

Fax: (52) 715-40863

Add: 14 Cambridge Center Cambridge, MA 02142

E-mail: [email protected]

Tel: (617) 679-2000

President/CEO: Alfredo Gallegos

Fax: (617) 679-2617

R&D expertise: Research of plant-tissue culture, related novel products development.

Web site: www.biogen.com

Key sales market contracts: USA; Europe; South America. Technological expertise: C/TC, H/CF, T

President: James R. Tobin Research director: Joseph M. Davie, M.D., Ph.D.

Principal products/instrumentation: Largescale production, ornamental plants, aquaves, transgenic potatoes, plant-tissue culture.

R&D expertise: Developing, manufacturing of testing products for the treatment of multiple sclerosis, inflammatory diseases, certain cancers and viruses.

Subsidiary bodies: T.C. lab and controlled greenhouses.

R&D collaboration: Genovo, Ontogeny.

Sealed and granted patents: Two patents.

385 BIOGENEX LABORATORIES, INC. Add: 4600 Norris Canyon Rd. San Ramon, CA 94583 Tel: (925) 275-0550 Fax: (925) 866-2594 Web site: www.biogenex.com President/CEO: Dr. Krishan Kalra Research director: Dr. Jianfu Wang R&D expertise: Clinical diagnostics R&D. R&D collaboration: Innogenex, Inc. Technological expertise: G, HTDS, H/CF, PA

Key sales market contracts: CSL LTD., Astra, Schering-Plough (Spain). Key license and trade contracts: Abort Labs, Green Cross, Imcera Group, Mallinckrodt Medical, Merck, Organon Teknika, ScheringPlough, Shinogi & Co., SmithKline Beecham. Technological expertise: F, Q, RD, P/S, BA, C/TC, GA, SY, AB, DD Principal products/instrumentation: Patented genetically engineered hepatitis B antigenssurface, core and ‘e’; Intron A alpha-IFN, Avonex Interferon BETA-la for multiple sclerosis. Main products/instrumentation under R&D: Beta-IFN for hepatitis, basal cell carcinoma and cervical dysplasia, Phase III, 2008; VLA-4 antibody, PhaseI/II, 2008; LFA3TIP, Phase I, 2008;

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AVonex (interferon beta-1a), for idiopathic pulmonary fibrosis, cancer, Phase II; adenosine A1 (antagonist CVT-124), for congestive heart failure, Phase II, 2008; natalizumab (Lucentis) treat regional iteitis, Phase III, 2008. Subsidiary bodies: Research Triangle Park, NC. Sealed and granted patents: Recombinant DNA molecules and their method of production. 6,268,122, U.S.; Common gamma chain monoclonal antibody blocking agents. 6,323,027, U.S.; Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction. 6,764,681, U.S.; Hepatitis B virus inhibitors. 6,544,520, U.S.; Recombinant antiVLA-4 antibody molecules. 6,602,503, U.S.; HBV core antigen particles with multiple immunogenic components attached via peptide ligands. 6,627,202, U.S.; Cell adhesion inhibitors. 6,630,512, U.S.; Ret ligand for stimulating neutral and renal growth. 6,677,135, U.S.; Chromatographically concentrated baculovirus and methods. 6,326, 183, U.S.; Cell adhesion inhibitors. 6,875,743, U.S. (2008); others are pending.

387 BIOGENY PLC

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Principal products/instrumentation: Vaccines, anti-viral agents, gene expression system, vector for polypeptide translocation. Main products/instrumentation under R&D: Anti-virals drug, polypeptides translocation system; Hep C therapy.

388 BIOGNOSIS GMBH Add: Karl-Heinz-Beckurts-Str. 13 Julich 52428 Germany Tel: (49) 2461-690-250 Fax: (49) 2461-690-275 E-mail: [email protected] President: Dr. John L. Meers Research director: Dr. Peter Miethe Subsidiary of Biognosis Ltd. R&D expertise: Research, development, production and marketing of various diagnostic products, mainly point-of-care. Technological expertise: E, H/CF, PA Principal products/instrumentation: ABICAP clinical diagnostic agent, clinical diagnostic aid, diagnostic reagents.

389 BIOHIT, OY.

Add: 46 Lansdoune Rd. London EN11 2LR UK

Add: Laippatie 1 Helsinki 00880 Finland

Tel: (44) 20-7727-1397

Fax: (358) 9 77-386200

Fax: (44) 20-7229-8115

E-mail: [email protected]

E-mail: [email protected]

Web site: www.biohit.com

President/CEO: Jeffrey Pike

President: Osmo Suovaniemi

Research director: Prof. Andresa Crisanti

Research director: Erkki Vesanen

R&D expertise: Research and development of vectors for polypeptide translocation, gene therapy research.

R&D expertise: Developer, manufacturer and exporter of liquid handling products for drug research laboratories.

Joint ventures: Imperial College, Porton Down.

Principal products/instrumentation: Electronic and mechanical pipettes (tips, microplates and other accessories), pipette washer.

Technological expertise: DD, GT

Tel: (358) 9 77-3861

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390 BIO-IMAGING TECHNOLOGIES, INC. Add: 826 Newtown-Yardley Rd. Newtown, PA 18940 Tel: (267) 757-1360 Fax: (267) 757-1361 President/CEO: Rex Bright Research director: James J. Conklin, M.D. R&D expertise: Medical imaging for core laboratory research, digital management services, regulatory submission software, and their products development. Technological expertise: CH/S Main products/instrumentation under R&D: Core lab medical imaging processing and quantitative image analysis services for clinical and preclinical development; Bio/ImageBase digital image analysis/management services for regulatory submission of image data, medical imaging regulatory system.

purification kit; CircleGrow high density growth media, bacteria in capsule form; BioFloat small microcentrifuge tube rack for water-bath, bench or storage; FastPrep Nucleic Acid Extraction System, RPM Plasmid Kit, Floraclean Kit. Main products/instrumentation under R&D: New media formulations; DNA purification; Plasmid isolation, plasmid purification, plasmid replication, DNA recombination. 392 BIOINSIDE GMBH Add: Warthestr. 21 Teltow bei Berlin D-14513 Germany Tel: (49) 3328-305190 Fax: (49) 3328-305192 E-mail: [email protected] Web site: www.bioinside.com President: Dr. Frank-Roman Lauter Research director: Dr. Roger Petersen Subsidiary of Genescan-Europe AG

391 BIO 101, INC. Add: P.O. Box 2284 La Jolla, CA 92038 Tel: (760) 929-1700; (800) 424-6101 Fax: (760) 918-9313 E-mail: [email protected] Web site: www.biol01.com President: J. Gautsch R&D expertise: Research of nucleic acid purification, molecular biology, bacterial/yeast growth media. DNA/RNA isolation and purification, manufacture of custom media for molecular biology. Key sales market contracts: Savant. Technological expertise: RD, F, P/S, E, GA, C/TC Principal products/instrumentation: GeneClean rapid DNA purification process kit; CirclePrep rapid plasmid DNA isolation/

R&D expertise: DNA Analysis, DNA kit and other DNA products development. Technological expertise: GA, HTDS, RD, PMC, DK Principal products/instrumentation: GMO detection kits; Microbial detection kits, DNA detection kits. Main products/instrumentation under R&D: DNA purification kits, DNA synthesizer, DNA thermal cycler, DNA probe. 393 BIOINVENT INTERNATIONAL AB Add: Solvegatan 41 Lund S-223 70 Sweden Tel: (46) 46-286-8550 Fax: (46) 46-211-0806 E-mail: [email protected] Web site: www.bioinvent.com President: Svein Mathisen

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Research director: Carl Borrebaeck, CSO R&D expertise: Research, development and large-scale contract manufacturing of monoclonal antibodies and other animal cell derived products performed in GMP certified production facility. Cell and tissue culture, Isolation and development of human antibodies through its proprietary human antibody library, nCoDeR. Large-scale contract manufacture of antibody-based drugs at state-of-the-art cGMPcertified facility. Technological expertise: BA, C/TC, D-D, HTDS, P/S, SY, PMC, LP

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Technological expertise: AF, AB, BI, BA, BS, CB, C/TC, COC, CH/S, GA, GT, H/CF, PIS, PMC, P/S, R, SY Main products/instrumentation under R&D: Continued R&D studies on early-stage lyme technology; continued R&D studies on chicken interferon; avian interferon.

395 BIOLOGICAL INDUSTRIES CO., LTD. Add: Kibbutz Beit Haemek 25115 Israel

Principal products/instrumentation: Monoclonal antibodies; biologicals; proprietary technologies on isolation and selection of human monoclonal antibodies including synthetic antibody library technology, SAP and CLAP selection systems and affinity manipulation technology; animal cell culture, animal protein factor.

Tel: (972) 4-966-0595

Main products/instrumentation under R&D: Therapeutic antibody product candidate Bl-204 (anti-oxLDL), in Phase II trial for patients with low-density lipoprotein (LDL) cholesterol, 2009.

R&D expertise: Cell and tissue culture, molecular biology research.

394 BIO-INVESTIGATIONS, LTD. Add: 32 Country Way Madison, CT 06443 Tel: (203) 421-3697 Fax: (203) 421-3697 President/CEO: Stewart Rosenberg R&D expertise: Development of biotechnology medicines; acquisitions; capitalization of emerging technologies; licensing of technologies. R&D collaboration: Connaught/Pasteur Merieux exclusive agreement on early stage lyme disease; DeKalb/Monsanto agreement on avian/chicken interferon and Embrex, INC. agreement on avian/chicken interferon. Key license and trade contracts: Worldwide direct sublicensing and licensing relationships with Connaught and the University of Connecticut.

Fax: (972) 4-966-8896 E-mail: [email protected] Web site: www.bioind.com President/CEO: Dr. Gary Bennett Research director: David Fiorentini

Technological expertise: C/TC Principal products/instrumentation: Sera, media, biologicals, reagents and other reagents and disposables for cell culture and molecular biology; Synthetic media and supplements sterile sera products, serum-free media products, ECM-coated plasticware, endotoxin testing, pilot-scale lyophilization, contract sterile filling, kits for molecular biology.

396 BIOLOGICAL RESEARCH FACULTY & FACILITY, INC. Add: 10075-20 Tyler Place Ijamsville, MD 21754 Tel: (301) 831-8810 Fax: (301) 831-8842 E-mail: [email protected] Web site: www.BRFF.com President/CEO: Dr. P. Thomas Iype

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Research director: Dr. P. Thomas Iype R&D expertise: Contract R&D of biotechnology medicines. Technological expertise: C/TC, PMC Principal products/instrumentation: Anticancer research products, GLP-compliant nonclinical product safety testing and specialized cell culture reagents for growing fastidious epithelial cell cultures such as human prostate and human breast cells, anticancer compound, anticarcinogen.

397 BIOLOGICS & CO. Add: 795A Heritage Village Southbury, CT 06488 Tel: (203) 262-8349 President: H. Felton R&D expertise: Bioinformatics, research and development of related products.

bacteria and yeasts, and filamentous fungi, 2008; MicroStation System and 6 MicroPlate Products. Technological expertise: GN, GP, ES, YT, SF-N, SF-P. Main products/instrumentation under R&D: OmniLog PM System for use with Biolog’s Phenotypic MicroArray panels. Sealed and granted patents: Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials, 6,692,239, U.S.; other patents pending.

399 BIOLOG, LIFE SCIENCE INSTITUTE Add: Flughafendarnm 9a P.O. Box 107125 Bremen D-28071 Germany Tel: (49) 042-159-1355 Fax: (49) 042-159-79713 E-mail: [email protected]

Technological expertise: RD, BI, COC, G, PG

Web site: www.biolog.de

Principal products/instrumentation: Bioinformatics, biosensors, bioremediation, biologicals.

President/CEO: Dr. H-G. Genieser

398 BIOLOG, INC.

R&D expertise: R&D of signal transduction, second messenger analogs, chromatography, metabolic monitoring, custom R&D, nucleotide chemistry, custom purification, metabolic monitoring.

Add: 3938 Trust Way Wayward, CA 94545

R&D collaboration: University of Bremen.

Tel: (510) 785-2564

Technological expertise: P/S, SY, E, D-D, SMC

Fax: (510) 782-4639 E-mail: [email protected] Web site: www.biolog.com President/CEO: Tim Mullane Research director: Barry Bochner, Ph.D. R&D expertise: Research, development and production of microbiology diagnostics. Technological expertise: CH/S, PMC, G Principal products/instrumentation: MicroLog Microbial Indentification/Characterization System for identify anaerobic and aerobic

Principal products/instrumentation: Hydrolytically stable activators and inhibitors of protein kinase A and G, rare nucleotides, nucleotides and cyclic nucleotides, signal transduction research tools, inositol phosphates, affinity chromatography products, triphosphate analogs; nucleobase, ribose and phosphate, modified nucleotides, nucleotides and cyclic nucleotides, activators and cyclic nucleotides activators and inhibitors for signal transduction research, hydrolysis resistant nucleotide affinity media.

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Sealed and granted patents: Inhibitors of cGMP-dependent protein kinase.

400 BIOLOGOS, INC. Add: P.O.Box 920 Naperville, IL 60566-0920

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Principal products/instrumentation: Block Magic, rebuilding of valve blocks used in ABI instruments; Phoenix, 1995 — 4 column DNA synthesizer upgrade; Cycleaver 12, 1996 — 12 column cleavage instrument for DNA. Main products/instrumentation under R&D: High throughput DNA synthesizer.

Tel: (630) 961-2440; (800) 246-4088 Fax: (630) 961-2443 E-mail: [email protected] Web site: www.biologos.com President: Dennis Raine

402 BIOLYTIX AG Add: Benkenstrasse 254 Witterswil CH-4108 Switzerland

R&D expertise: Development and production of medical and veterinary biologicals.

Tel: (41) 61-723-2070

Technological expertise: P/S, BA, C/TC, F

E-mail: [email protected]

Principal products/instrumentation: Prosup-76, TC grade fetal bovine serum, Donor herd horse serum, Antibody nondetectable donor calf serum, bovine serum, porcine serum.

Web site: www.biolytix.com

Main products/instrumentation under R&D: Custom formulations, product containers, chick serum, hog cholera serum, polyvalent serum.

401 BIOLYTIC LAB PERFORMANCE, INC. Add: 39120 Argonaut Way PMB #229 Fremont, CA 94538 Tel: (510) 795-1142 Fax: (510) 795-1149 E-mail: [email protected] Web site: www.Biolytic.com President: Thomas J. Demmitt Research director: Tom Demmitt R&D expertise: Instrument research and custom instruments development. Key sales market contracts: Prime Synthesis. Technological expertise: CH/S, R, SY

Fax: (41) 61-723-2071

President: Christoph Keigel Research director: Serge Kocher R&D expertise: Molecular biological analysis and custom products development. Technological expertise: GA, GT, T Principal products/instrumentation: Biological, diagnostics, custom development products, vaccines, reagents, enzymes, antibodies.

403 BIO-M AG, MUNICH BIOTECH DEVELOPMENT Add: Am Klopferspitz 19 Martinsried/Munchen Bavania 82152 Germany Tel: (49) 0-89-89-96790 Fax: (49) 0-89-89-967979 E-mail: [email protected] Web site: www.bio-m.de CEO: Prof. Dr. Horst Domdey R&D expertise: Research and development of biotechnology products; BioTech seedfinancing, location marketing for BioTechRegion Munchen, business consulting.

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Technological expertise: C/TC Principal products/instrumentation: Custom research products. Main products/instrumentation under R&D: Peptides, seed culture, seed plant cultivate, enzymes, vaccines, reagents, antibodies.

404 BIOMARIN PHARMACEUTICAL, INC. Add: 105 Digital Dr., Novato, CA 94949

Main products/instrumentation under R&D: Aldurazyme (alronidase for injection), treat mucopoly saccharidosis-1 (MPS-1), Phase III completed, 2008; X-L-iduroniadase (ALDURA2YME, alronidase), Phase I/II/III; Nacctyl-galactosaminc 4-sulfatase, preclinical; Vibriolysin (for burn debridement), preclinical; Anti-Fungal enzymes, preclinical; Phase II trial of BMN 110, or N-acetyl-galactosamine 6-sulfatase (GALNS), in approximately 20 patients with mucopolysaccharidosis type IVA (MPS IVA), or Morguio A syndrome, 2009.

Tel: (415) 506-6570 Fax: (415) 506-6583 E-mail: [email protected] Web site: www.bmrn.com CEO: Grant W. Denison, Jr. Research director: Christopher M. Starr, Ph.D. R&D expertise: Research, development and production of carbohydrate enzyme therapies for debilitating, life-threatening, chronic genetic disorders and other diseases and conditions. Joint ventures: Genzyme Corporation. Key license and trade contracts: Harbor-UCL Women’s and Children’s Hospital, W.R. Grace. Technological expertise: P/S, E, F, RD, GA, AF, S, C/TC, ABI and Biosearch synthesizers, ABI valve block rebuilds. Principal products/instrumentation: Face Imaging System (Carbohydrade analysis) FACE; Urinary Screening Test, (Lysosomal Storage Diseases); Reagents, Kits, Enzymics (Glycobiology); Naglazyme Galsulfase for Treatment of patients with Mucopolysaccharidosis VI (MPS VI), 2005; Kuvan (sapropterin dihydrochloride) indicated to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalan inemia (HPA) due to tetrahydrobiopterin (BH4) responsive PKU and is to be used in conjunction with a Phe-restricted diet (oral), 2007.

405 BIOMATIC CONSULTING, INC. Add: 488 Hobart Rd. North Brunswick, NJ 08902 Tel: (732) 297-4106 E-mail: [email protected] Web site: www.biomatic-consulting.com President: Johannes G. Mooyman, Ph.D. M.B.A., M.S. Chem. Eng. Research director: Hans Mooyman. Joint ventures: W. R. Grace, IMCERA, Umon Camp, John Brown Eng. & Construct, Lockwood Greene, Union Camp Inc. R&D expertise: Biotechnology consulting, technology transfer, software development, auditing-validation. Technological expertise: E, F, AF, BI, BA, CH/S, RD, C/TC, LP Principal products/instrumentation: Biologicals, bioremediation, specialty chemicals, food processing, natural products, process validation, computer software, Database management programs Quizer; XY-t Base, XY-t plot, HTL- High Tech Linking; HTL-M.

406 BIOMATION INSTRUMENTS Add: 335 Perth St, P.O. Box 156 Almonte, Ontario KOA 1AO Canada

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Tel: (613) 256-2821 Fax: (613) 256-5872 Web site: www.biomation.com President: Dave Hanneson R&D expertise: Medical biology research products development. Key sales market contracts: Mega oy (Finland). Technological expertise: PMC Principal products/instrumentation: Biofeedback devices, biofeed back control systems.

407 BIOMATRIX, INC. Add: 65 Railroad Ave. Ridgefield, NJ 07657 Tel: (201) 945-9550

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ophthalmic disorders, Hylaform correction for facial wrinkles; For skin care industry: Biomatrix, Hyladerm, Biocare HA-24, Biocare SA, Polytrix, Biocare Polymer BHA-10, Biocare HA-24 BIO, Hylasome. Main products/instrumentation under R&D: Hylagel — Uro, to treat urinary incontinence; Hylagel to control adhesions; Hylagel Vase, treatment of arteriovenous malformations; HsS to protect and moisten corneal surface during surgery; Hylashield 24, ophthalmic viscoprotection & lubrication; Hyiasol ophthalmic viscosurgery; Hylasine post surgical anti-adhesion device following sinus surgery; Hylagel Eye, ophthalmic viscosupplementation. Subsidiary bodies: Biomatrix Medical Canada, Inc. — manufacturing and sales subsidiary in Pointe-Claire, Quebec.

Fax: (201) 945-0363 Web site: www.biomatrix.com President: Rory B. Riggs Research director: Endre A. Balazs, M.D. R&D expertise: Research, development, and commercialization and manufacture of viscoelastics made from proprietary biological polymers called hylans, used in therapeutic medical applications and skin care products. Hylan products for medical applications in such specialties as orthopedics, rheumatology, ophthalmology, rhinology, neurology, urology, dermatology, and general and plastic surgery. Key sales market contracts: Amerchol Corp. (subsidiary of Union Carbide), Collagen Corp., Equinord, Farmila Farmaceutica Milano Srl, IMed Pharma, Recordati Industria Chimica e Farmaceutica SpA, Rhone-Poulenc Rorer Inc., Roche AB, Wyeth-Ayerst, Boehringer Ingeiheim, Bayer AG.

408 BIOMAT SNC Add: Via Zeni 8 Rovereto 38068 Italy Tel: (39) 04-64-443320 Fax: (39) 04-64-443159/443320/443112 E-mail: [email protected] President: Dr. M. Pettenati Research director: Dr. M. Pettenati R&D expertise: Development and production of biotechnology medicines. Technological expertise: PPAT, CB Principal products/instrumentation: 96 Wells plates with special surfaces; HB (high binding capacity) MB (medium binding capacity) LB (low binding capacity), animated carboxylated maleimide — streptavidin-Protein A; Concanavalin.

Technological expertise: DD, CB, TE Principal products/instrumentation: Medical Products: Synvisc for osteoarthritis treatment; Hylashield Nite- corneal viscoprotection for overnight use; Hylashield for topical

409 BIOMEC, INC. Add: 1771 East 30th St. Cleveland, OH 44114 Tel: (216) 937-2800

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Fax: (216) 937-2812

411 BIOMEDIA GMBH

E-mail: [email protected] Web site: www.biomec.com President: John A. Redmond Research director: Dr. James M. Moran R&D expertise: Biomedical product research, development and commercialization. R&D collaboration: BF Goodrich. Key license and trade contracts: Cleveland Clink Foundation. Technological expertise: R, TE, BA, CH/S, DD, PMC, P/S Principal products/instrumentation: Biomaterials, biosensors, contract research/clinical trials products, diagnostics, vaccines, antibodies, enzymes, peptides, reagents.

410 BIOMEDA CORP. Add: 1166 Triton Dr., Ste. E. Foster City, CA 94404 Tel: (650) 341-8787 Fax: (650) 341-2299 E-mail: [email protected] Web site: www.biomeda.com President: Jose Perdomo Research director: Dr. Bader Siddiki R&D expertise: Development of biological products for research use only in pathology and immunology laboratories, relative products manufacture.

Add: A. Sommerfeld — Ring 2 Baesweiler D52499 Germany Tel: (49) 2401-805450 Fax: (49) 2401-805451 E-mail: [email protected] Web site: www.bioportfolio.com/biocorporate/ 1645-Biomedia+GmbH.html President/CEO: Dr. Elmar Michels Research director: Michael Gismann R&D expertise: Development and production of in vitro diagnositics (immunoassay kits; antibodies; rec. proteins; instrumentation) for use in laboratory research and development. R&D collaboration: Cell diagnostica GmbH, Munster. Key sales market contracts: Cell diagnostica GmbH, Munster. Technological expertise: C/TC, H/CF, AB, P/PS Principal products/instrumentation: Cytokine ELISA Kits, biomedia; Monoclonal antibodies (tumor markers, apoptosis, inflammatory processes), biomedia; Recombinant proteins, biomedia. Main products/instrumentation under R&D: Allergy screening test (quantitative, multiparameter membrane assay), approaching market introduction, other in vitro diagnostic kits.

412 BIOMEDICA GRUPPE

Technological expertise: P/S, H/CF, C/TC, CH/S, BI

Add: Divischgasse4 Vienna A-1210 Austria

Principal products/instrumentation: Crystal/ Mount, AutoProbe III, UltraProbe, BioStain ABC kits, CK22 antibody, phycobiliproteins conjugated to secondary antibodies, PhycoProbe. LAB/Probe kit detection systems.

Fax: (43) 1-291-0785

Tel: (43) 1-291-0750 E-mail: [email protected] Web site: www.biomedica.co.at CEO: Prof. Dr. Wolfgang Woloszczuk

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Research director: Dr. Gerhard Hawa

President: Tom Mitchell

R&D expertise: Development and production of medical products, immunoassays diagnostics, research reagents, heart surgery, nephrology, nuclear medicine.

Research director: Dr. Savvas Damaskines

Technological expertise: E, PA, PS/AP

R&D collaboration: Allelic Biopharmaceuticals; Genetic Microarray Consortium.

Principal products/instrumentation: Endothelin, Big Endothelin; natriuretic peptides, proANP, proBNP; Oxidative Stress, OLAB; Vitamin D, 25-OH VIT D; Peroxide, Borrelia LgG+LgM, cell proliferation, biomedical research reagents, biomedical products immunoassays diagnostics.

413 BIOMEDICAL FRONTIERS, INC. Add: 1095 10th Ave., S.E. Minneapolis, MN 55414

R&D expertise: Research, development and production of confocal laser imaging of gene chips and genetic microarrays.

Technological expertise: G, CH/S, R, GA Principal products/instrumentation: DNA scope — Confocal scanner for microarrays. Main products/instrumentation under R&D: Confocal laser imaging products of gene chips. Sealed and granted patents: 6 patents on confocal imaging.

415 BIOMEDICAL PRODUCTS CORP.

Tel: (612) 378-0228 Fax: (612) 378-3601 President/CEO: Bo Hedlund, Ph.D. Research director: Paul Dragsten, Ph.D. R&D expertise: Development and production of high molecular weight iron chelators, MRI contrast agents. Technological expertise: P/S, SY Main products/instrumentation under R&D: Anti-oxidant, Phase Ib; iron chelator, Phase II/III; magnetic resonance imaging contrast agent, toxicology.

414 BIOMEDICAL PHOTOMETRICS, INC. Add: 560 Parkside Dr. Waterloo, Ontario N2L 5Z4 Canada Tel: (519) 886-9013 Fax: (519) 886-8442

Add: 10 Halstead Rd. P.O. Box 538 Mendham, NJ 07945 Tel: (973) 543-7434 Fax: (973) 543-7497 E-mail: [email protected] President: John Geppert R&D expertise: Development and production of home health diagnostic tests to OTC, home, labs, drug stores. Key sales market contracts: Cryobiogenics. Technological expertise: TE, T Main products/instrumentation under R&D: Xeno transplant for arteries and veins, organs; home health diagnostic tests to OTC. Sealed and granted patents: Xeno Transplants.

416 BIOMEDICAL TECHNOLOGIES, INC.

E-mail: [email protected]

Add: 378 Page St. Stoughton, MA 02072

Web site: www.confocal.com

Tel: (781) 344-9942

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Fax: (781) 341-1451

E-mail: [email protected]

Web site: www.btiinc.com

President: Philippe Crine

President: Maurice Larnarque

R&D expertise: Development and production of metallopeptidase, bone, cardiovascular.

R&D expertise: Development and manufacture of products for life science research and biotechnology marketplace. Technological expertise: PA, C/TC Principal products/instrumentation: Growth factors, cell growth and attachment factors, RIA and ELISA kits, lipoproteins, other proteins and antibodies.

417 BIOMED LABORATORIES, LTD. Add: 28, Eastern Way, Pontelan Newcastle upon Tyne NE20 9PF UK Tel: (44) 16-08-811081

Key license and trade contracts: Université de Montréal. Technological expertise: E, F, PA, Q, BI, BA, C/TC, COC, D-D, H/CF, PIS, SMC, SY Principal products/instrumentation: Chemicals, contract research products, biopharmaceuticals. Main products/instrumentation under R&D: Metallopeptidase, bone morphogenetic protein.

419 BIOMERICA, INC.

Fax: 44 16-61-8243902

Add: 1533 Monrovia Ave. Newport Beach, CA 92663

E-mail: [email protected]

Tel: (949) 645-2111

Web site: www.biomed.demon.co.uk

Fax: (949) 722-6674

CEO: Dr. G. A. Turner

Web site: www.Biomerica.com

Research director: Dr. G. A. Turner

President: Zackary Irani

R&D expertise: Contract carbohydrate analysis and reagents and kits for the investigation of carbohydrate composition and structure.

R&D expertise: Research, development and production of immuno diagnostics.

Technological expertise: CB Principal products/instrumentation: Lectin analysis kit. Main products/instrumentation under R&D: Carbohydrate Electrophoresis kits, lectin affinity chromatography, reagent of carbohydrate composition and structure.

418 BIOMEP, INC.

Key sales market contracts: Bio-Rad, FujiRebio, Nis-shin. Technological expertise: AF, PA, TE, T, DD Principal products/instrumentation: One step H-pylori test; Allergy treatment (oral).

420 BIOMETALLICS, INC. Add: P.O. Box 2251 Princeton, NJ 08543 Tel: (609) 275-0133; (800) 999-1961

Add: 4631 Cumberland Montreal, Quebec H4B 2L5 Canada

Fax: (609) 275-9485

Tel: (514) 343-7001

Web site: www.microplate.com

Fax: (514) 343-7018

President/CEO: Christa Kuehn

E-mail: [email protected]

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Research director: Delores Nichols/Kristin Ruzzi.

Tel: (800) 932-7250

R&D expertise: Research, development and production of micro plate analysis software, veterinary diagnostic test kits.

E-mail: [email protected]

Technological expertise: HTDS, P/S, PIS, PA, RD, AB, C/TC, CH/S Principal products/instrumentation: DELTASOFT 3, Target Progesterone Test Kit, microplate analysis software.

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Fax: (352) 860-0918 Web site: www.biometra.de President: Tony Sanchez Research director: Tony Sanchez R&D expertise: Development, production and marketing of instruments and biologicals to biotechnology, clinical and research labs. Technological expertise: GA, RD, Q

421 BIOMETICS, INC. Add: 300 Bear Hill Rd. Waltham, MA 02451 Tel: (781) 684-8331 Fax: (781) 684-8335 E-mail: [email protected] Web site: www.biometicsma.com

Principal products/instrumentation: TRIO, UNOII, UNO and PERSONAL Cycler Thermocyclers, PRIMZYME thermostable DNA polymerase, COMPACT and DUOTHERM hybridization ovens, vertical and horizontal electrophoresis instruments, FAST-BLOT, DOTBLOT 96 and VACUBLOT blotting systems, WHATMAN 3mm blotting paper.

President: Stephen Fitzpatrick, Ph.D. R&D expertise: Biopharmaceutical production facility design & validation, project management, process engineering, architecture, cGMP consulting.

423 BIOMIDE CORPORATION Add: 21 Kercheval, Ste. 330 Grosse Pointe Farms, MI 48236

Technological expertise: RD, F, P/S, BA, FE, E, LP, BS, RD, HTDS, C/TC, PMC, CH/S, GT, DD, validation, construction projects, systems design.

Tel: (313) 886-0589

Principal products/instrumentation: Biologicals, vaccines, specialty chemicals, monoclonal antibodies, gene therapy, biodrug facilities, fermentation technology, chromatography technology, continuous bio-waste system technology and novel validation techniques.

Research director: Kenneth V. Honn, Ph.D.

Subsidiary bodies: Second Office Location: 277 Lakeshore Road East, Ste 408, Oakville, Ontario, L6J1H9, Canada, Tel: (905) 8491833, Fax: (905) 849-9734.

422 BIOMETRA, INC. Add: 8410 Gobbler Dr. Floral City, FL 34436

Fax: (313) 886-1301 President: Arthur T. Porter, M.D. R&D expertise: Therapeutic molecules that induce apoptosis in cancer, R&D products manufacture. Technological expertise: COC, SMC Main products/instrumentation under R&D: All therapeutic molecules in preclinical trials, apotosis in cancer. Subsidiary bodies: Laboratory: Detroit, MI.

424 BIOMIDI Add: 35 Ave. Marcel Dassault Pare de la Plaine Toulouse 31502 France

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Tel: (33) 5-6134-0714 Fax: (33) 5-6134-9306 President: Patrick Espenan R&D expertise: Development and production of electrophoresis. Technological expertise: BME, AMS Principal products/instrumentation: Electrophoresis equipment, electrophoresis-grade reagents, electrophoresis buffer, electrophoresis chamber.

425 BIOMIRA, INC. Add: Edmonton Research Park 2011-94th St. Edmonton, Alberta T6N 1H1 Canada Tel: (403) 450-3761 Fax: (403) 463-0871 E-mail: [email protected] Web site: www.biomira.com President/CEO: Alex McPherson, M.D., Ph.D. Research director: B. Mike Longenecker, Ph.D. R&D expertise: Cancer vaccines research and products manufacture. Joint ventures: Chiron — Commercialization of Theratope therapeutic, immunotherapeutic for treatment of metastatic breast cancer.

Principal products/instrumentation: Biologicals, monoclonal antibodies, synthetic carbohydrates. Main products/instrumentation under R&D: Theratope (synthetic carbohydrate therapeutic vaccine) for metastatic breast cancer, Phase II — complete; BLP25, Phase I/II — underway; Liposomal IL-2, preclinical; Liposomal Idiotypic Vaccine, preclinical. Subsidiary bodies: Biomira USA, 1002 Eastpark Blvd., Cranbury, NJ 08512, Tel: (609) 655-5300, Fax: (609) 655-1755: Mircea Popescu, V.P. Research and Development. Sealed and granted patents: 5,798,090 — Theratope vaccine; 4,963,484, 5,503,489 — MUC-1 (BLP-25); 5,527,891 — Glycopeptide synthesis; 5,296,353, 5,583002; 5,556,763; 5,658,744 — STEP; 5,409,698, 5,773,006, 5,560,152, Liposomal-IL-2 & B-Lymphoma Vac-one; 4,971,795, 5,443,983, 5,316,763, 5,641,677, 5,725,855 — Adoptive Cell Therapy; Enhancement of the cellular immune response. 6,326,009, U.S.; Enhancement of the cellular immune response. RE38, 046, U.S.

426 BIOMIRA USA, INC. Add: 1002 Eastpark Blvd. Cranbury NJ 08512 Tel: (609) 655-5300 Fax: (609) 655-1755

Key sales market contracts: Licenses to in vitro MAbs to Tosoh, Chiron Diagnostics and Behring Dade Diagnostics, recently assigned to Centocor.

Web site: www.biomira.com

Key license and trade contracts: Biosyn Arzeimittel — exclusive worldwide supply agreement for KLH for STn Vaccine. ICRF worldwide license for Mucl vaccine patents; Dana Farber license to Kufe Mucl patents in U.S.

Subsidiary of Biomira Inc.

Technological expertise: B, H, C, O, F, PI, L, M, lyophilization vialing.

Main products/instrumentation under R&D: Theratope (synthetic carbohydrate therapeutic

President/CEO: Alex McPherson Research director: Mircea C. Popescu, M.D., Ph.D. R&D expertise: Cancer immunotherapy research, anticancer drug manufacture. Key license and trade contracts: Roche. Technological expertise: DD

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vaccine), treat meatstatic breast cancer, Phase III/ IV; OncoLipin, Phase III; Onco-Cell, Phase II/III; OncoSTEP, Phase II, OncoV-AX, Phase II. Sealed and granted patents: 5,296,353 Evaluation & Treatment of Patients with Progressive Immunosuppression; 5,556,763 Oncostep patent; 5,409,698 Liposome Immunoadjuvants Containing IL-2; 5,316,763 Short-Term AntiCD3 Stimulation of Lymphocytes to increase their in vivo activity, 5,443,983; Method of culturing lymphocytes and method of treatment using such lymphocytes; Vaccine for B-cell malignancies, 6,312,718, U.S.; Multilamellar coalescence vesicles containing biologically active compounds, 6,544,549, U.S.; others are pending.

427 BIOMOLECULAR ASSAYS, INC. DBA BMA LABS Add: 25 Olympia Ave Unit S Woburn, MA 01801

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Fax: (505) 474-5203 Web site: www.biomolecular.com President: Steven Willhoite Research director: Pavel Bondarenko Subsidiary of Thermo Bioanalysis R&D expertise: Research and manufacture of bioanalytical and medical equipment. Technological expertise: BME Principal products/instrumentation: MALDITOF mass spectrometer, dynamo; capillary electrophoresis, crystal; capillary electrophoresis, liltra; capillary electrophoresis, ce-100; bioactive analytic equipment.

429 BIOMOLECULAR TECHNOLOGIES, INC. Add: 525 Del Rey Ave, Ste. F. Sunnyvale, CA 94086-3515 Tel: (415) 813-0445

Tel: (617) 932-3959

Fax: (415) 813-0430

Fax: (617) 932-8705

E-mail: [email protected]

E-mail: [email protected]

President: Marcus Horn, Ph.D.

President/CEO: James A. Laugharn

R&D expertise: Development and manufacture of peptide products, peptide instrumentation, protein chemistry, proteome research, post-translational modifications.

Research director: David J. Green, Ph.D. R&D expertise: Contract biomolecular assays devices development and testing. Joint ventures: BioAmp, Inc.

Joint ventures: Pharmacia Biotech.

R&D collaboration: Epigen, Bioseq.

Key license and trade contracts: Exclusive co-license signed in 1997.

Technological expertise: E, Q, P/S, PMC, GA

Technological expertise: Q, BI, R

Principal products/instrumentation: Biologicals, biomolecular assays devices, diagnostics, plastics, custom other development products.

Principal products/instrumentation: Protein processing system, model 9501 Protein Processing Station, Model 9502 Sample Loading Station.

428 BIOMOLECULAR INSTRUMENTS Add: 504 Airport Rd. Santa Fe, NM 87505 Tel: (505) 471-6124

Main products/instrumentation under R&D: Integrated Reaction Chemistry Cassettes for use with Model 9501 Protein Processing Station and the Model 9502 Sample Loading Station; Automated C-terminal, protein-peptide sequencer.

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430 BIOMOL GMBH Add: Waidmannstrasse 35 Hamburg D-22769 Germany Tel: (49) 40-85-32-600 Fax: (49) 40-85-32-6022

Technological expertise: PA, AB, RD, SMC, HTDS, SY Principal products/instrumentation: QuantiZyme Assay Kits; QuantiPak Assay Kits; Biomol Green Reagent; Casputin Reagent, Screen-Well Libraries for HTS, signal transduction kits.

E-mail: [email protected] Web site: www.biomol.de President: Manfred Konnertz Research director: Hans-Jurgen Heilmann

432 BIONATEC

Subsidiary of NR

Add: 664 Rue des 3 Moulins Sophia Antipolis 06600 France

R&D expertise: Reagents research and development.

Tel: (33) 4-9291-7160

Key sales market contracts: Distribution agreements.

E-mail: [email protected]

Technological expertise: SY Principal products/instrumentation: Signal transduction reagents, general reagents, antibodies, nucleosides, nucleotides, coenzymes, bioactive peptides, biologically active buffers, detergents and biotensides, enzymes, growth factors, electrophoresis reagents, enzyme substrates. Main products/instrumentation under R&D: Biotensides, immunochemicals, novel peptides.

431 BIOMOL RESEARCH LABORATORIES, INC. Add: 5120 Butler Pike Plymouth Meeting, PA 19462-1202 Tel: (610) 941-0430

Fax: (33) 4-9291-7169 President/CEO: Gaetano Zannini Research director: Jean Pierre Mathonnet R&D expertise: Development, production and marketing of natural health food products and cosmetic products based on a new technology biogranules and bioperles [pearls]. Key sales market contracts: Distribution agreements in Italy, Canada, Spain and Taiwan. Technological expertise: DD Principal products/instrumentation: Biogranules; biotyfruit; phytomalines; not back; topergy; aromalines; equiphase. Main products/instrumentation under R&D: Pearls for bath which allows a regular and long delivery of essential oils, natural health food. Sealed and granted patents: PCX Patent under progress.

Fax: (610) 941-9252 E-mail: [email protected] Web site: www.biomol.com

433 BION DIAGNOSTIC SCINECES, INC.

President: Robert Zipkin, Ph.D. Research director: Konrad Kowitz, Ph.D. R&D expertise: Research of biochemicals and kits for signal transduction, products manufacture.

Add: 12277 134th Ct. NE Redmond, WA 98052 Tel: (425) 821-1010 Fax: (425) 814-1520

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E-mail: [email protected] Web site: www.biondiagnostics.com CEO: Drew Cervasio Research director: Robert Kinders Subsidiary of Polymedico, Inc. R&D expertise: Research of cancer diagnosis, and related therapeutic products developments. R&D collaboration: Abbott Human cancer diagnostic. Key sales market contracts: Abbott labs, be cancer diagnostic, Fujrebio — Japanese cancer distribution. Technological expertise: BI, C/TC, GA, H/CF, P/S, SY, Q, PA, CS Principal products/instrumentation: BTA stat test; Assay V-BTA Test. Main products/instrumentation under R&D: Colon cancer diagnostic, clinical. Sealed and granted patents: Complement regular 6017703, U.S.

434 BIONEBRASKA., INC.

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Type II Diabetes, preclinical; GRF plus PTH for osteoporosis, preclinical. Sealed and granted patents: Patents covering application of GRF and GRF in combination with PTH for osteoporosis; monoclonals specific for heavy metals; recombinant processes for production, purification and amidation of peptides (2001); chiorella virus promoters,6,316,224, U.S.

435 BIONET Add: 26 Rachel Imenou Jerusalem 93228 Israel Tel: (972) 2-567-1553 Fax: (972) 2-563-1963 E-mail: [email protected] President: Pierre Girard Stein R&D expertise: Research and manufacture of reagents and kits for diagnostic. Principal products/instrumentation: Agriculture, biologicals, clinical tests, diagnostics, natural products, reagents, kits for diagnostic, enzymes.

Add: 3820 NW 46th St. Lincoln, NE 68524 Tel: (402) 470-2100 Fax: (402) 470-2345 President: Fred W. Wagner, Ph.D. Research director: Barton Holmquist, Ph.D.

436 BIONICHE, INC. Add: 383 Sovereign Rd. London, ON N6M 1A Canada

R&D expertise: Development and manufacture of recombinant regulatory peptide hormone replacement for therapeutics; diagnostic and environmental immunoassay tests for toxic metals.

Tel: (519) 453-2418

Technological expertise: F, Q, GA, PIS, P/S, RD, H/CF

R&D expertise: Biotechnology.

Principal products/instrumentation: BiMelyze Mercury Soil Test.

Technological expertise: F, G, P

Main products/instrumentation under R&D: GRF for osteoporosis, Phase II/III; GLP-1 for

Fax: (519) 453-2481 President: Graeme McRae, Vice Chairman Research director: Catherine Hilderbrand Key license and trade contracts: IPC Nordic. Principal products/instrumentation: Suplasyncontract manufacturing products biopharmaceuticals.

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Main products/instrumentation under R&D: Regressin, Phase III/IV; cystistal, preclinical.

R&D collaboration: Various institutions in North America and Europe.

Sealed and granted patents: Cystistat, Regressin.

Key license and trade contracts: Various institutions in North America and Europe. Technological expertise: PA, P/S, C/TC, H/CF

437 BIONIQUE TESTING LABORATORIES, INC. Add: Fay Brook Dr. RR I, Box l96 Saranac Lake, NY 12983 Tel: (518) 891-2356 Fax: (518) 891-5753 E-mail: [email protected] Web site: www.bionique.com President/CEO: Daniel J. Lundin Research director: Carolyn Kay Lincoln, Ph.D.

Principal products/instrumentation: Polyclonal and monoclonal antibodies for signal transduction, apoptosis, DNA repairs, immunoglobulins subclasses and infectious diseases. Main products/instrumentation under R&D: Novel kits (ELISA format). Subsidiary bodies: Bionostics Ltd., The Business Centre, Tythe Farm, Wyboston, Beds MK44 3AT; Tel: (01) 480-47-7733; Fax: (01) 480-47-7744.

439 BIONOVA HOLDING CORPORATION

R&D expertise: Mycoplasmal testing research of cell cultures and related products for the pharmaceutical, biotechnology.

Add: 6701 San Pablo Ave. Oakland, CA 94608

Technological expertise: PA, HF, C/TC, BP

Tel: (510) 547-2395

Principal products/instrumentation: CELLshipper, SAFE CELLS, mycoplasmal screening assays for the detection of mycoplasmas in cell, cell cultures and related products.

Fax: (510) 450-9342 President: Jorge Fenyvesi Research director: John Bedbrook, Ph.D. Subsidiary of Savia, S.A. de C.V (76% owned)

438 BIONOSTICS, INC. Add: 48 Meadow Brook Rd. Ste. 3 North York, Ontario M6B 2S6 Canada

R&D expertise: Development and production of agricultural biotechnology for fruits and vegetables. Joint ventures: Monsanto.

Tel: (416) 789-3936

R&D collaboration: Seminis Vegetable Seeds.

Fax: (416) 783-8360 E-mail: [email protected]

Key license and trade contracts: AgrEvo, Novartis, Monsanto.

Web site: www.bionostics.com

Technological expertise: T, C/TC, RD

President/CEO: Earl Madorsky

Principal products/instrumentation: Master’s Touch and Freshworld Farms fruits and vegetables.

R&D expertise: Development, production and supply novel antibodies and associated reagents at affordable pricing to research and diagnostic sectors.

Main products/instrumentation under R&D: Pest resistant fruits and vegetables.

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Sealed and granted patents: TranSwitch Gene Suppression; Chitinase Gene; various genes and transformation technology.

440 BIO NOVA INTERNATIONAL PTY, LTD. Add: 36 Munster Terrace P. Box 359 North Melbourne, Victoria 3051 Australia Tel: (61) 03-326-6955 Fax: (61) 03-329-8071 E-mail: [email protected]

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Joint ventures: Biodevelopment Laboratories, Bristol-Meyers Squibb. Key license and trade contracts: The John Hopkins Oncology Ctr., Southwest Foundation for Biomedical Research. Technological expertise: D-D Principal products/instrumentation: Therapeutic drug for cancer.

442 BIO-OPTRONICS, INC.

Web site: www.bionova.com.au

Add: 3385 Brighton-Henrietta TL Rd. Rochester, NY 14623

CEO: Hugh McCormack

Tel: (716) 272-3040

R&D expertise: Research, development and production of therapeutic drugs for vascular disease.

Fax: (716) 272-7273

R&D collaboration: CSIRO, University of Melbourne. Key sales market contracts: Distributors in France, Italy, Austria, Switzerland, Thailand, Taiwan, Middle East, Japan, UK, Germany. Technological expertise: BA, C/TC, TE Principal products/instrumentation: Vascular prostheses, Omniflow II; soft tissue patches. Main products/instrumentation under R&D: Coronary bypass graft, implantation graft.

441 BIONUMERIK PHARMACEUTICALS, INC. Add: 8122 Datapoint Dr. Ste. 1250 San Antonio, TX 78229 Tel: (210) 614-1701 Fax: (210) 614-0643 President: Dr. Frederick H. Hausheer Research director: Dr. Frederick H. Hausheer R&D expertise: Development and production of cancer therapeutics.

President: Michael S. Kamish R&D expertise: Research of process-based quality improvement and pollution prevention, data-acquisition and control software. Technological expertise: CH/S, PMC Principal products/instrumentation: IPPS System (Intelligent Pollution Prevention System); Product Testing Software; Vibration Analysis Software, data acquisition and control software.

443 BIO-OZADVANCED BIOTECHNOLOGICAL AGRICULTURE, LTD. Add: Kibbutz Nahal Oz D.N. NEGEV 85145 Israel Tel: (972) 7-680-5429 Fax: (972) 7-680-5448 E-mail: [email protected] CEO: Dr. Gal Yarden R&D expertise: Development and manufacture solutions of biological protection for a variety of crops from different types of plant diseases to attain higher yields.

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R&D collaboration: Academic institutions in Israel. Key sales market contracts: With all the largest plant nurseries in Israel. Technological expertise: T, RD, CB Principal products/instrumentation: Cucurbit cross-protection against viruses. Main products/instrumentation under R&D: Virus vector, field trials, biological protection of crops plant diseases.

Technological expertise: F, E, BA Principal products/instrumentation: Metabolic modeling software, natural products, pharmaceuticals, contract research products. Main products/instrumentation under R&D: Metabolic modeling.

446 BIOPHAGE, INC. Add: 6100 Royalmount Montreal, Quebec H4P 2R2 Canada

444 BIOPAC SYSTEMS, INC.

Tel: (514) 496-1488 Fax: (514) 496-1521

Add: 42 Aero Camino Santa Barbara, CA 93117 Tel: (805) 967-6615 Fax: (805) 967-6403 E-mail: [email protected] Web site: www.biopac.com President/CEO: Alan Macy

E-mail: [email protected] Web site: www.biophage.com President/CEO: Rosemonde Mandeville Research director: Kishore Murthy R&D expertise: Contract research; R&D in oncology, infections and immunology.

Research director: William McMullen

Key license and trade contracts: Canadian government.

R&D expertise: Medical research workstations.

Technological expertise: PA, P/S, DD, D-D

Technological expertise: PMC, CH/S

Main products/instrumentation under R&D: Breast cancer vaccine; Teiomerase Phage Therapy inhibitors; Immune Modulator; New liposome formulation, Teiomerase Isoform Inhibitors, Phage Therapy Rapid Diagnostic Kits.

Principal products/instrumentation: ACQKNOWLEDGE, MP100WS, MP100WSW, biomedical research workstations.

445 BIOPEP, LTD. T/A BIOFLUX Add: Colville Building 48 North Portland St. Glasgow, Scotland Gl 1XN UK

447 BIO-PHARM CLINICAL SERVICES, INC.

Fax: (44) 141-548-4809

Add: Four Valley Square 512 Township Line Rd. Blue Bell, PA 19422-2724

E-mail: [email protected]

Tel: (215) 283-0770

CEO: Dr. David Mousdale

Fax: (215) 542-2726

Research director: Dr. Jill Meiville/Dr. Manila Fischer

President/CEO: Geraldine A. Henwood, Ph.D.

R&D expertise: Improve bioprocesses by analysis and modeling.

R&D expertise: Drug clinical research and development services.

Tel: (44) 141-548-4808

Research director: Stuart Hamill, Ph.D.

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Joint ventures: De-Skor, Inc.; Moscow Russian Federation. R&D collaboration: Germany.

LPT

Hamburg

Key sales market contracts: Midlantic Bioresearch — Temple Hills, MD; Aster/ Cephac — Paris, France. Technological expertise: DD Principal products/instrumentation: Biologicals, contract research/clinical trial drug, diagnostics, natural products, vaccines, enzymes, reagents, antibodies. Subsidiary bodies: Brussels, Belgium; Chippenham, UK; Durham, NC, USA; Ft Washington, PA, USA; Hamburg, Germany; Moscow, Russia; Paris, France; Prague, Czech Republic; Redwood City, CA, USA; Rheinfelden, Switzerland; Sydney, Australia.

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449 BIOPIGMENT, LTD. Add: P.O. Box 80 Kiryat Arba 90100 Israel Tel: (972) 2-996-3880 Fax: (972) 2-996-1571 E-mail: [email protected] Web site: www.greentech.co.il Research director: Vladimir Boiko R&D expertise: Development and production of iron oxide pigments for industry. Technological expertise: BA Main products/instrumentation under R&D: Iron oxide pigments of high quality, produced from scrap iron (laboratory prototype completed).

450 BIOPOLYMER TECHNOLOGIES INTERNATIONAL, INC. 448 BIOPHARM GMBH

Add: P.O. Box 84 Westborough, MA 01581

Add: Czernyring 22 Heidelberg D-69004 Germany

Tel: (508) 366-4089

Tel: (49) 6221-53830

E-mail: [email protected]

Fax: (49) 6221-538320

President/CEO: Manssur Yalpani

E-mail: [email protected]

Research director: Manssur Yalpani

Web site: www.biopharm.de

R&D expertise: Application research of biopolymer-based technologies for pharmaceuticals, nutraceutical, agricultural and specialty chemical products; carbohydrate biotechnology.

President: M. Paulista Research director: R. Bechtold, Ph.D. and J.S. Pohl, Ph.D. R&D expertise: Cytokine research and analytical services in molecular biology (genetic engineering/expression) and protein biochemistry. Key license and trade contracts: Hoechst AG. Technological expertise: Q, E, RD, P/S, GA, C/TC Main products/instrumentation under R&D: Two new members of the FGF-beta family of growth factors, cytokine network.

Fax: (508) 836-3862

Technological expertise: AF, CB, DD, D-D, SY Main products/instrumentation under R&D: Microencapsulated agricultural products, cholesterol-lowering drug, preclinical; cosmetic gelling agent, antiinfective drug, preclinical.

451 BIOPROCESSING, INC. Add: 4 Washington Ave. Scarborough, ME 04074 Tel: (207) 883-0110

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Fax: (207) 883-1482 E-mail: [email protected] President: Gary Goodrich Research director: Karen Lawrence R&D expertise: OEM research of human proteins particularly in the tumor marker area, products manufacture. Technological expertise: BA, C/TC, PA, P/S Principal products/instrumentation: Cancer antigens; human protein market of breast, ovarian and gastrointestinal tumor.

development of protocols for particular product purification, endotoxin removal. Subsidiary bodies: Bioprocessing Inc., 116 Village Blvd., Suite 200, Princeton Forrestal Village, Princeton, NJ 08540, Tel: (609) 9512243, Fax: (609) 951-2217.

453 BIOPROCESSING TECHNOLOGY CENTRE Add: National University of Singapore 10 Kent Ridge Crescent 119260 Singapore Tel:

452 BIOPROCESSING, LTD.

Fax: E-mail: [email protected]

Add: Medomsley Rd. Consett, Co. Durham DH8 6SZ UK Tel: (44) 1207-581555 Fax: (44) 1207-500944 E-mail: [email protected] President/CEO: Dr. John Heap, CEO Research director: Dr. Kami Beyzavi Subsidiary of Bioprocessing Corp. R&D expertise: Development and marketing of cell and tissue culture products and technologies for protein purification using Prosep affinity purification products; peptide synthesis, endotoxin removal. Key license and trade contracts: University of Surrey.

Web site: www.eng.nus.edu.sg/btc/ President: Miranda Yap, Dir. R&D expertise: Contract development and production in bioprocessing. Joint ventures: Genset Singapore Biotech P/L. Key license and trade contracts: QED Biosdence Inc., San Diego, USA Technological expertise: BA, C/TC, COC, H/CF, PIS, P/S, SY, F, PA, Q Principal products/instrumentation: Biologicals, biomaterials, reagents, contract development products. Subsidiary bodies: GMP Biopilot Facility (Year 2000).

Technological expertise: P/S, BA, PA Principal products/instrumentation: Prosep high performance affinity products; cell and tissue culture products pre-packed affinity columns; contract purification; process development technology; customized affinity adsorbent development technolotgy, Prosep products for large-scale purification of antibodies, specific affinity absorbents, contract purification of customer proteins from cell culture, prosep affinity purification products, and

454 BIOPROCESS TECHNOLOGY CONSULTANTS Add: 24 Wright Farm Rd. Concord, MA 01742-1528 Tel: (978) 371-1733 Fax: (978) 371-1738 E-mail: [email protected] Web site: www.bioprocessconsultants.com

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President: Howard L. Levine, Ph.D.; Diane I. Blumenthal. R&D expertise: All aspects of research, design, process development, products manufacturing, engineering and validation, including cell line selection and scale-up development and validation of downstream processes, development of manufacturing strategies, technology transfer, facility design and validation, and contract manufacturing. Regulatory consulting for CMC-related activities.

pre-registration trials), current dandelion bioherbicide.

456 BIOPRO INTERNATIONAL, INC. Add: P.O. Box 156 Tel: 265 Conklin St. Farmingdale, NY 11735 Tel: (516) 249-0099 Fax: (516) 249-0494

Technological expertise: BTC, P, AB, MAE, RD, PC, PS, PPAT, PS/AT, RPP.

E-mail: [email protected]

Principal products/instrumentation: Peptides, recombinant proteins, monoclonal antibodies, and vaccines.

President/CEO: Rene F. Lohser

Main products/instrumentation under R&D: Cell factor, cell directed inhibitor, cell analyzer, validation of downstream processes.

455 BIOPRODUCTS CENTRE, INC. Add: 101-111 Research Dr. Saskatoon, SK S7N 3R2 Canada Tel: (306) 668-2652 Fax: (306) 975-1966 E-mail: [email protected]. sk.ca President: Stephane Dupont, Ph.D. R&D expertise: Biological crop. protection and growth enhancement products. R&D collaboration: For current Dandelion Bioherbicide Project between DowElanco Canada Inc., Saskatchewan Wheat Pool, Philom Bios Inc., Nova Scotia Agricultural College, McGill University, University of Guelph and the BioProducts Centre Inc. Technological expertise: BA, C/TC, F Main products/instrumentation under R&D: Mycoherbicide for the control of dandelion and other broadleaf weeds in turf in early development (preliminary efficacy and

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Web site: www.biopro.com Research director: Dr. Henry Bondi, Ph.D. R&D expertise: Research, development and production of bioprocess engineering products, cell and tissue culture; Marketing of state-ofthe-art processing equipment and instruments used for research, development and production of biochemicals, therapeutic drugs, enzymes, vaccines, antibodies and other biological products in USA and Canada. Key sales market contracts: Bioengineering AG, Switzerland — fermenters/bioreactors and related processing equipment with accessories and controls; Kuhner AG, Switzerland — biological shakers; Aquasant AG, Switzerlandturbidity meters; M. Christ GmbH, Germany — freeze dryers; DrM, Switzerland — STERIBAC filters; Graber & Pfenninger, Switzerland — vibrating mixers; Snamprogetti Biotechinologie — mobile pilot plant; Contardi, Italymultiple fermenter systems; Segnetron, Israel — DO sensor; Nisco Ltd., Switzerland — Encapsulation; Immobilization; Prior Eng. Ltd., Austria — continuous chromatography Fungilab, Spain — viscosity meters; Esco, Singapore — Laminar flow cabinets; Kühni, Switzerland — agitated extraction columns. Key license and trade contracts: Preparative Continuous Chromatography. Joint ventures: Bioengineering AG, Switzerland; Aquasant AG, Switzerland; Snamprogetti

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Biotechnology, Italy; Kuhner AG, Switzerland. Prior Separation Technology, Austria; Martin Christ, Germany; NISCO Engineering, Switzerland.

Main products/instrumentation under R&D: Protein supplements for animal feeds; post pilot studies; recovery processing instruments of agricultural and food wastes.

Technological expertise: F, C/TC, E, BA, P/S, CH/S, PMC, RD, H/CF, TE

Sealed and granted patents: Processing/ Fermentation.

Principal products/instrumentation: Fermenters/Bioreactors: Laboratory KLF and NLF 22, pilot, product, fluidized bed, airlift, rotor filter, membrane, film, high pressure perfusion, foamkill; Biological Shakers: Incubator shaker cabinet, ISF-1-W, rack system; Freeze Dryers: Lab pilot and production; Sterile Solid/Liquid Separation: FUNDABAC; Turbidity Meter: Aquasant AS82/AF445; Vibrating Mixers: Lab size 1 to production size 4; multiple fermenter system; special DO sensor; Cellbag Bioreactor; Encapsulation/immobilization systems; continuous chromatography; Viscometers; Agitated extraction columns; Incubation shaker cabinets, control systems, fermenter systems, cell culture bioreactors, containment systems, vibrating mixers, turbidity meters, on-line process analyzer, spiral filters for cell concentration and cell-free sampling, rotofilter systems for perfusion cell culture, DO analyzers, mobile modular biotech plants, continuous chromatography, viscosity meters, solid liquid separation, encapsulation/ immobilization systems, vacuum concentrators and freeze dryers. Subsidiary bodies: 16 service representatives nationwide.

458 BIOPROX, INC. Add: 6036 Sheaff Lane Ft. Washington, PA 19034 Tel: (215) 542-8056 Fax: (215) 542-8194 E-mail: [email protected] Web site: www.bioprox.com President: Jorn Dan Benedictus Research director: Jorn Dan Benedictus R&D expertise: Development of fermentation process, related novel products manufacture. Technological expertise: BA, CC, E, F, P/S, SMC Principal products/instrumentation: Fermentation processes products molecule pharmaceuticals and select fine chemicals, fermentor. Main products/instrumentation under R&D: Fermenter controller, fermentograph, fermentor agitation devices, etc. Sealed and granted patents: Proprietary only, no interest in patents.

457 BIO-PROTEUS CORP. 459 BIOPTECHS Add: P.O. Box 7048 Wilmington, DE 19803 Tel: (302) 478-6160

Add: 3560 Beck Rd. Butler, PA 16002

Fax: (302) 478-3667

Tel: (724) 282-7145

President: John F. Bingaman

Fax: (724) 282-0745

R&D expertise: Management/recovery of agricultural and food processing wastes.

E-mail: [email protected]

Technological expertise: BA, F

President/CEO: Dan Focht

Web site: www.bioptechs.com

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Research director: Nicholas A. Pezzuolo

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461 BIOQUAL, INC.

R&D expertise: R&D, manufacturing and marketing of live cell microobservation system and custom microscopic systems.

Add: P.O. Box 388 North Ryde, NSW 1670 Australia

Key sales market contracts: 60 worldwide.

Tel: (61) 2-987-88199

Technological expertise: C/TC, CH/S

Fax: (61) 2-988-87774

Principal products/instrumentation: Focht Chamber System, FCS; Delta T Culture Dish System, Delta T; Objective Heater System, live cell microobervation system.

E-mail: [email protected] Web site: www.bioquestoz.com President: James Kelly Research director: Angus Gidley-Baird, Ph.D.

460 BIOPURE CORP. Add: 11 Hurley St. Cambridge, MA 02141 Tel: (617) 234-6500 Fax: (617) 234-6505 President: Jim O’Shea Research director: Bing L. Wong, Ph.D. R&D expertise: Develop & test of red blood cell substitute for human and veterinary treatment use; separation & purification technology for manufacturing of red blood cell substitute. Joint ventures: Associated Synapse Biologics, Cephagen Corp. R&D collaboration: B. Braun Melsungen, The Upjohn Co. Key license and trade contracts: B. Braun Melsungen, Boehringer Mannheim. Technological expertise: F, P/S, BA, E, BS Principal products/instrumentation: Tissue culture additive, various enzymes, ultrapure bovine hemoglobin. Main products/instrumentation under R&D: Red blood cell substitute for human and veterinary treatment use. Subsidiary bodies: Subsidiary bodies: 39 Hurley St., Cambridge, MA 02141; 4 Progress Dr. Dover, NH 03820.

R&D expertise: Research, development and manufacture of biological reagents. Key sales market contracts: CSIRO: steroidassay reagents. Technological expertise: PA, LP, BA, P/S, H/CF, C/TC Principal products/instrumentation: Monoclonals, polyclonals, contract purification, sterile packing, freeze drying, assay development and kits, SIROSERA steroid assay reagents, hormones, immunoglobulins. Main products/instrumentation under R&D: Veterinary diagnostic assays, R&D; steroid diagnostic reagents, advanced development; enzymes, antibodies.

462 BIO-RAD LABORATORIES, INC. Add: 1000 Alfred Nobel Dr. Hercules, CA 94547 Tel: (510) 724-7000; (510) 741-5817 Fax: (510) 741-5815 Web site: www.bio-rad.com President/CEO: David Schwartz R&D expertise: Development of products for life science research. Technological expertise: BI, BA, CB, CH.S, D-D, GA, G, HTDS, PIS, PG, PA, LP, E

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Principal products/instrumentation: Gene pulser electroporation system, E.col; pulsar electroporation system, Biolistic system, variant II, Unity for windows, Excalibur, Clinical Systems Network, Protean II, Sadtler suite, Molecular imager EX, Singray, specialty chemicals. Subsidiary bodies: Over 70 offices worldwide.

463 BIORECLAMATION, INC. Add: 61 Tec St. Hicksville, NY 11801

Research director: Larry Niesen R&D expertise: Downstream processing research and novel products development. Principal products/instrumentation: X-Flo crossflow membrane filters, X-Flo Lab Systems, X-Flo Prep System, X-Flo pilot systems, X-Flo Process System. Main products/instrumentation under R&D: Processing technology.

465 BIORELIANCE

Tel: (516) 483-1196

Add: 14920 Broschart Rd. Rockville, MD 20850-3349

Fax: (516) 483-4683

Tel: (301) 738-1000; (800) 553-5372

E-mail: [email protected]

Fax: (301) 738-1036

President: Michael Gatz

E-mail: [email protected]

Research director: Michael Gatz

Web site: www.bioreliance.com

R&D expertise: One source research for all biologicals; special projects using animals and humans.

President: Capers W. McDonald

Joint ventures: Chimera — Osteoporosis test. Technological expertise: F, PA, Q, TE, T, BI, BA, BS, C/TC, GA, H/CF, P/S, RD, DD, PG Principal products/instrumentation: IIR (Immunoglobulin Inhibiting Reagent); Animal cDNA, Human cDNA, serum free media, monkey serum, fetal calf serum, human serum, Mab-Max. Main products/instrumentation under R&D: Osteoporosis office test, Phase II; cDNAhuman disease state. Sealed and granted patents: Osteoporosis test.

464 BIO-RECOVERY, INC. Add: P.O. Box 2310 River Vale, NJ 07675 Tel: (201) 784-9396 Fax: (201) 784-0151

Research director: John A. Gilly, Ph.D. R&D expertise: Contract biodrug research organization for pharmaceutical, biopharmaceutical, medical device and chemical companies, biological safety assessments including assays for viral and other contaminants of mammalian cell- and blood-plasma-derived products and analytical methods for protein characterization; a wide range of cGMP and GLP compliant biopharmaceutical and pharmaceutical development services, including drug biosafety, analytical, carcinogenicity and toxicology testing, purification process validation, cell line characterization, formulation development, stability and lot release testing services and laboratory animal health services; and cGMP banking and contract manufacturing for microbial products, including recombinant and nonrecombinant bacteria and yeasts, and viral-based products including retroviral, adenoviral and other gene therapy vectors for clinical trials. Contract manufacturing-production services for cell and virus banks, viral vectors

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used for gene therapy, viral vaccines, tumor vaccines, and recombinant proteins using microbial fermentation technology. Genetic toxicology — services for the detection of toxic mutagenic, clastogenic, and morphological transforming activity in a number of wellcharacterized test systems. General and Molecular Toxicology — traditional single dose, 14-day or 28-day repeated dose and 90-day subchronic studies. Animal Diagnostic services including serological and comprehensive health testing for laboratory animals, also including rodents, rabbit and non-human primates. Technological expertise: F, LP, BA, C/TC, GT, P/S, RD Joint ventures: National Institutes of Health. Principal products/instrumentation: BioSafety testing for viral and other contaminants of mammalian cell derived and blood/plasmaderived products; Process Validation-studies for biopharmaceuticals to quantitate the inactivation and removal of relevant and model agents; Bioanalytical testing for determining product. Stability Testing-programs for real-time realconditions stability data; Contract manufacturing products of viral vectors (retroviruses, adenoviruses, adeno-associated viruses, and others) for gene therapies; viral vaccines, and cells for cellular therapies. Main products/instrumentation under R&D: Viral vector design and optimization, derivation of custom-produced cell lines, and alternative gene therapy delivery techniques; quantitative PCR. Subsidiary bodies: BioReliance Ltd., Scion House, Innovation Park, Hillfoots Road, Stirling, FK9 4NF, Scotland; BioReliance GmbH, Czernyring 22, D-69115 Heidelberg, Germany.

466 BIORELIANCE MANUFACTURING GMBH Add: Czernyring 22 Heidelberg 69115 Germany

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Tel: (49) 62-21-90260 Fax: (49) 62-21-902690 E-mail: [email protected] Web site: www.BIORELIANCE.com President: Hans Peter Kneubuehl Research director: Thomas Pultar, Ph.D. R&D expertise: Contract development and manufacturers for clinical grade bulk material under cGMP (PIC and US-FDA), bioprocess engineering products manufacture. Major partners: E. Merck, B. Braun., Byk Gulden. Key sales market contracts: Major U.S. and European pharmaceutical companies. Technological expertise: F, P/S, RD, LP Principal products/instrumentation: Thrombolytics, vaccines, diagnostics, enzymes, reagents, antibodies, peptides.

467 BIORESEARCH IRELAND Add: Enterprise Ireland Glasnevin Dublin 9 Ireland Tel: (353) 1-837-0177 Fax: (353) 1-837-0176 E-mail: [email protected] Web site: www.biores-irl.ie President/CEO: Dr. James Ryan Research director: Seamus O’Hara R&D expertise: Bioprocess engineering products, contract R&D and novel technology development in biotechnology. R&D collaboration: Innogenetics, Molecules To Market, Dr. Kert Thomas — GmbH, Berlex Bioscience, Innogenetics, Inhibitex Cross Vetpharm. Key sales market contracts: Dainippon Pharmaceutical Co. Ltd.; Kamiya; Kayaku, QED. Key license and trade contracts: Trinity Biotech Plc.

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Technological expertise: CC, E, F, Q, TE, RD, GT, G, LP, P/S, PMC, BA, BI, C/TC, DD, D-D, GA, H/CF

R&D expertise: Research, design and automation manufacture of biorobotics for the genetic research market.

Principal products/instrumentation: Biologicals, vaccines, enzymes, monoclonal antibodies, single cell proteins antibiotics, specialty chemicals. Human and veterinary diagnostic cell culture products technology transfer opportunities. Salivary Progesteronc EIA, salivary Oestradiol EIA, Myoglobin Latex assay antistreptokinase Antibody EIA, Multiple Drug resistance Antibodies — MAB MDR-1; MAB LRP; Briclone-Human hybridoma cloning medium; Equine fertility — progesterone EIA; Oestrone Sulphate EIA, PMSG EIA. Brovine Fertility — Serum Progesterone EIA, PMSG EIA. Brovine Fertility — Serum Progesterone EIA; Milk Progesterone EIA.

Technological expertise: BI, GT, R, G

Main products/instrumentation under R&D: Biological control of potato cyst nematode; probiotics & novel antimicrobial agents; coeliac disease-marker antibody detection; biocatalysts for chiral synthesis; combination cancer therapy; DNA probe generation methods; mutation detection.

Principal products/instrumentation: Biopick, a fully automatic colony harvesting robot, the Biogrid, an automated filter preparation and library replication robot, Microgrid, an instrument for preparing high density microarrays on solid substrates, Mircrogrid II high throughput, high density microarrayer. Microgrid general purpose arraying platform. BioPick automated colony picker. Subsidiary bodies: BioRobotics Inc., Boston, USA.

469 BIOSCAN, INC. Add: 4590 MacArthur Blvd. Washington, DC 20007 Tel: (202) 338-0974 Fax: (202) 333-8514 E-mail: [email protected]

Subsidiary bodies: 5 University-based R&D centers.

Web site: www.bioscan.com

Sealed and granted patents: Generation of specific probes for target nucleotide sequencer. U.S. 5,574,145, plus a range of patent applications in all biotechnologies.

Research director: Seth D. Shulman

468 BIOROBOTICS, LTD.

President/CEO: Seth D. Shulman R&D expertise: Research, development and manufacture of instrumentation. Principal products/instrumentation: System 200 Imaging Scanner; Lumi-Scint; QuickCount; Flow-Count, System 2000 Imaging Scanner, pharma-synthesizer.

Add: Barton Rd. Haslingfield Cambridge CB3 7LW UK Tel: (44) 1223-873500 Fax: (44) 1223-873589 E-mail: [email protected]

470 BIOS CHILE INGENIERIA GENITICA S.A.

Web site: www.biorobotics.com

Add: Avda. Marathon 1943 Nunoa Santiago Chile

President: Dr. Martin Davies

Tel: (56) 2-238-1878

Research director: Stuart Elmes

Fax: (56) 2-239-4250

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472 BIOSCIENCE, INC.

Web site: www.bioschile.cl President: Pablo D.T. Valenzuela, Ph.D. Research director: Luis Burzio R&D expertise: R&D of diagnostics, custom antibody production and biologicals.

Add: 1550 Valley Center Pkwy, Ste. 140 Bethlehem, PA 18017-2263 Tel: (610) 974-9693; (800) 627-3069 Fax: (610) 691-2170

Key sales market contracts: Life Technologies, Rainrn Instrument Ventana/Medical System. Mj Research, Visys.

E-mail: [email protected]

Technological expertise: RD, F, P/S, H/CF, C/TC, Q, E

R&D expertise: Research and development of environmental biotechnology related products.

Principal products/instrumentation: Diagnostic reagents, blood typing products, biologicals.

Technological expertise: F, BA, PMC

Main products/instrumentation under R&D: Novel diagnostics, antibodies, enzymes, peptides, vaccines.

471 BIO SCIENCE CONTRACT PRODUCTION CORP.

Web site: www.bioscienceinc.com President: T.G. Zitrides

Principal products/instrumentation: Microcat microbials; Bl-1000 respirometers; Control biokinetic software; ER-100 respirometers; BIOX biotreaters; Accu-Test cod test kits; QBOD on-line BOD meter, Neupro rotigotine treatment of symptoms of early Parkinson’s disease, 2007.

473 BIOSCIENCE INNOVATIONS, INC.

Add: 5901 East Lombard St. Baltimore, MD 21224

Add: 1617 St. Andrews Dr. Ste. 210 Lawrence, KS 66047

Tel: (410) 563-9200

Tel: (785) 832-2110

Fax: (410) 563-9206

Fax: (785) 832-8234

E-mail: [email protected]

E-mail: [email protected]

Web site: www.bscp.com

Web site: www.bioinnovation.com

President: Steven Rubin

President/CEO: Dr. Ahmed Aced

Research director: Dr. Aaron Heifetz

Research director: Dr. Ahmed Aced

R&D expertise: GMP production of purified bulk biologics.

Subsidiary of Kansas Innovation Corp.

Technological expertise: BA, C/TC, GT, F, P/S, RD Principal products/instrumentation: Biologicals, contract manufacturing products, vaccines, reagents, enzymes, plasmid DNA purification, plasmid replication. Sealed and granted patents: Plasmid DNA Purification.

R&D expertise: Development and manufacture of highest quality biochemical analysis tools, specifically biosensors and capillary electrophoresis. Key sales market contracts: Phenomenex, Torrance, CA; P. J. Cobert St. Associates, St. Louis, MO. Key license and trade contracts: Univ. of Kansas, Lawrence, KS.

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Technological expertise: CC, P/S, BA

Fax: (858) 793-0742

Principal products/instrumentation: BSIC18 coated C.E. Column; BSI-SA Sulfonic coated C.E. column; BSI-AA™ — polyacrylarnide coated C.E. column; BSIChiroDex — chiral separation; C.E. kit with cyclodextrin reagent; B-1Q4, a 4-channel stem to monitor glutamate changes in vivo and in vitro.

E-mail: [email protected]

Main products/instrumentation under R&D: BSI-AA — polyacrylamide coated C.E. column; BSI-Chiro Dex — chiral separation C.E. kit with cyclodextrin reagent.

474 BIO-SCIENCE PTY, LTD. Add: 28 Monro Ave. P.O. Box 78 Kirrawee, NSW 2232 Australia Tel: (61) 2-9521-2177 Fax: (61) 2-9542-3100 E-mail: [email protected] Web site: www.biosci.com.au President/CEO: Man Metti Research director: Daryn Metti R&D expertise: Manufacture and supply of biomedical products and equipment into research and diagnostic laboratories. Technological expertise: AF, CC, E, F, PA, Q, TE, T, AB, BI, BA, BS, CB, C/TC, COC, GA, GT, DD, H/CF, PIS, PG, G, P/S, RD, SMC, SY Principal products/instrumentation: Cytokines, antisera, biochemicals, organic chemicals, plasticware, probes, laboratory equipment for drug research use.

Web site: www.palella.com/palella President: David A. Palella, M.B.A., M.S. R&D expertise: Biotechnology consultants, fifteen plus years experience in Japan-U.S. business. Founded BioScience Ventures in 1991. Retained consultants to major Japanese pharmaceutical companies and U.S., European, and Canadian Bioventure Companies. Technological expertise: BTC, SMC, HTDS, BI, G Principal products/instrumentation: JapanU.S. and U.S.-Europe strategic alliances for funding of R&D and clinical trials of novel biopharmaceutical and biomedical products. Out-licensing and in-licensing of novel therapeutic compounds, vaccines and diagnostic products. Professional networks of biotechnology: small-molecule combinatorial chemistry, molecular diversity, high-throughput screening (HTS), computational chemistry, chemoinformatics, molecular modeling, bioinformatics, high-speed gene sequencing & localization, functional genomics and proteomics.

476 BIOS (CONSULTANCY AND CONTRACT RESEARCH), LTD. Add: Pinewood, College Ride Bagshot Surrey GU19 5ER UK Tel: (44) 1276-473363 Fax: (44) 1276-473928 E-mail: [email protected] Web site: www.biosinternational.co.uk

475 BIOSCIENCE VENTURES, INC.

President: Keith Greenwood Research director: Dr. Alan Davies

Add: 3830 Valley Centre Drive, Suite 705/PMB #581 San Diego, CA 92130-3307 Tel: (858) 793-0741

R&D expertise: Drug consultancy and contract research for the pharmaceutical and allied industries.

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Principal products/instrumentation: Biologicals, chemicals, contract manufacturing products, contract research/clinical trial products, cosmetics, instrument, pesticides, pharmaceuticals, reagents, vaccines, reagents, enzymes, antibodies.

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Tel: (47) 555-43966 Fax: (47) 555-43771 E-mail: [email protected] Web site: www.biosense.no President: Audun Wiborg Research director: Anders Goksoyr

477 BIOSEARCH TECHNOLOGIES, INC. Add: 81 Digital Dr. Novate CA 94949 Tel: (415) 883-8400 Fax: (415) 883-8488 E-mail: [email protected] Web site: www.biosearchtech.com President: Dr. Ronald M. Cook, Ph.D. Research director: Dr. Ronald M. Cook, Ph.D. R&D expertise: Chemical research on related products for genomics development, design and manufacturing; specialized in labeled DNA, fluorogenic supports and reagents and solid supports for DNA synthesis. R&D collaboration: Multiple NIH-funded SBIR grants. Technological expertise: AB, COC, GA, G, PIS, PG, P/S, R, SMC, SY, CS Principal products/instrumentation: Black Hole Quencher, solid supports for synthesis, modified oligonucleotides, fluorogenic probes, peptide synthesizer, including new PEG-PS graft copolymer, champion resin. Main products/instrumentation under R&D: BioPolymer Arrays, Libraries, Bioconjugates, microtiter-plate formatted multiple synthesis configured for peptide modification by incorporation of fluorophores.

R&D expertise: Development and manufacture of antibodies and immuno diagnostic kits for analyzing biological effects of chemicals, toxins and pollutants. R&D collaboration: Brixham Environmental Laboratory (AstraZeneca, UK), Novartis Crop. Protection AG (CH). Key sales market contracts: Cayman Chemical Company (USA), Immuno-Biological Laboratories (JPN). Key license and trade contracts: Brunel University (UK), Sheffield University (UK), Umea University (Sweden), University of Florida (USA). Technological expertise: C/TC, H/CF, PA Principal products/instrumentation: Endocrine Disrupter Test (Vitellogenin), Biosense Vtg-ELISA, 2000. Vitellogenin Antibodies, Biosense Vtg. Main products/instrumentation under R&D: In vitro test for DSP in shellfish, In vitro test for microcystein in drinking water immuno diagnostic kits. Sealed and granted patents: PCT/GB99/ 03756.

479 BIOSEPARATIONS, INC. Add: 245 S. Plumer Ste. 28 Tucson, A2 85719 Tel: (520) 622-5882

478 BIOSENSE LABORATORIES A.S. Add: HIB-Thormohlensgt. 55 Bergen N-5008 Norway

Fax: (520) 622-4766 E-mail: [email protected] Web site: www.bioseparations.com President/CEO: David Sammons, Ph.D.

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Research director: Delia Bethell, Ph.D.

Fax: (301) 470-2333

R&D expertise: Prenatal genetics research, fluorescence imaging development and production.

Web site: www.bioserve.com

Technological expertise: P/S, CH/S

Research director: Terri Lehman

Principal products/instrumentation: Fluorescence in situ hybridization (FISH) buffers, ChromaHyb; Fluorescent imaging, ImageScan.

R&D expertise: Molecular biology research; diagnostics synthesis and services.

Main products/instrumentation under R&D: Prenatal genetics diagnostic system (PDS), preclinical.

480 BIO SERAE LABORATOIRES, SA. Add: BP6 Montolieu 11170 France

President: Rama Modali

Technological expertise: AB, F, P/S, GA, RD, GT, G, Q, SY, PIS Principal products/instrumentation: p53 Amplimer Kit, p53 Sequencing Kit, cancer diagnostic kits

482 BIOSIGNAL, INC.

Tel: (33) 6824-8532

Add: 1744 rue William, Ste. 600 Montreal, PQ H3J1R4 Canada

Fax: (33) 6824-8724

Tel: (514) 937-1010

President: M. Degre

Fax: (514) 937-0777

Research director: I. Degre

E-mail: [email protected]

R&D expertise: Development and production of lactoferrin/lactoperoxidase for pharmacy, nutrition, food technology; immunoglobulins for feed/food; colostrum for veterinary.

President: Dr. Michael Dennis

Technological expertise: F, C/TC, E, AF Principal products/instrumentation: Lactoferrin; lactoperoxidase; lactoglobulin; Colostrom STD 250; mare milk; enzymes and fungicides; DP 50; bovine immunoglobulins; bovine, ovine colostrum. Main products/instrumentation under R&D: Serazym process, a treatment for animal infections; ophthalmology: antivirus and antimicrobial eye lotions; Serazym process, enzymatic system, for microbial food decontamination, lactopontin, lactotransferrin.

R&D expertise: Research, development and production of protein purification, molecular biology, pharmacology and cell culture, etc. Principal products/instrumentation: G protein subunits, recombinant G protein-coupled receptors supplied in frozen cell membranes containing individual receptor subtypes.

483 BIOS INP. CO. LTD. Add: 1289 Matheson Blvd. E. Mississauga, ON L4W 1R1 Canada Tel: (905) 602-1930 Fax: (905) 602-1933 President/CEO: Guan-Huei Ho

481 BIOSERVE BIOTECHNOLOGIES, LTD. Add: 1050 West St. Laurel, MD 20707 Tel: (301) 470-3362

Research director: Guan-Huei Ho R&D expertise: Research, development and manufacture of biotechnology medicines and biomedical equipment and computer system, vaccines, reagents, antibodies, peptides.

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Technological expertise: BA, E, P/S

Web site: www.biosoft.com

Principal products/instrumentation: Food ingredients, immobilized enzymes, biochemicals, computer systems.

President: Dr. John W. Lamble

Sealed and granted patents: Two U.S. patents and three Canadian patents.

Technological expertise: CH/S

484 BIOS LABORATORIES, INC.

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R&D expertise: Biotechnology software scientific and engineering community. Principal products/instrumentation: Various scientific software computer programs; Gene Jockey II version 2 Operating System: Macintosh.

Add: 5 Science Park New Haven, CT 06511 Tel: (203) 773-1450

486 BIOSONDA, S.A.

Fax: (203) 562-9377 Web site: www.bioslabs.com President: Dr. Richard Kouri Research director: Dr. Gualberto Ruano R&D expertise: Gene mapping and characterization.

Add: Eduardo Castillo Velasio 2902 Santiago Chile Tel: (56-2) 209-6770 Fax: (56-2) 274-5462 E-mail: [email protected]

Key sales market contracts: Scotlab Ltd., Toyobo.

Web site: www.cepri.cl/biosonda

Key license and trade contracts: Scotlab Ltd., Scotlab, Inc.

Research director: Alfredo De loannes

Technological expertise: RD, GT, C/TC, Q Principal products/instrumentation: Somatic cell hybrid panels, Evo blots, gene mapping, gene transcription analysis — Northerns, developmental analysis — Northerns, DNA variation analysis, in situ chromosome localization, polymorphic STSs, Opti-Tag, Tag-IT, Human PI library screening service. Main products/instrumentation under R&D: Coupled amplification and sequencing, locus specific libraries, coupling regents.

485 BIOSOFT Add: P.O. Box 10938 Ferguson, MO 63135

President: Maria Ines Becker R&D expertise: Immunodiagnostic and immuno-biotechnology research, novel products development Technological expertise: C/TC, H/CF, PIS, PA, P/S, Q, SY Principal products/instrumentation: Blue Carrier; Monoclonal Antibodies to Acrosin; Monoclonal Antibodies to Gizerosine. Main products/instrumentation under R&D: Competitive ELISA for Histamine and Gizerosine, in development; immunodiagnostic reagents, immunodiagnostic kits.

487 BIOSOURCE, INC.

Tel: (314) 524-8029

Add: P.O. Box 550 34 Old Bridge Dr. Howell, NJ 07731

Fax: (314) 524-8129

Tel: (732) 905-5728

E-mail: [email protected]

Fax: (732) 905-5847

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E-mail: [email protected]

Fax: (508) 435-2199

President: Thomas J. Puskar

E-mail: [email protected]

R&D expertise: Development and manufacture of biochemicals, immunochemicals, cell culture, monoclonal antibodies, etc.

Web site: www.biosource.com

Technological expertise: F, P/S, BA, H/CF, C/TC, E, PA Principal products/instrumentation: Immunochemicals, Biochemicals for research and manufacturing.

488 BIOSOURCE INTERNATIONAL Add: 820 Flynn Rd. Camarillo, CA 93012 Tel: (805) 987-0086 Fax: (805) 987-3385 E-mail: [email protected] Web site: www.biosource.com President/CEO: Jim Chamberlain Research director: Kevin Reagan R&D expertise: Research, development and production of assays and reagents for the study of cell biology. Key license and trade contracts: Children’s Hospital of LA.

President/CEO: Jim Chamberlain Research director: Kevin Reagan R&D expertise: Research of peptide synthesis, antibody production, bioactive peptides, specialty chemicals, antibodies for neuroscience and cell biology, related products manufacture. Technological expertise: PIS, PA, SMC, SY, C/TC, GA, R Principal products/instrumentation: B-amyloid peptides, apoptosis peptides, kinase substrates and inhibitors (MAP Kinase, CaM Kinase, PKC, PKA), cell permeable PKC inhibitors (Isoform-specific), signal transduction antibodies, QCB-Select AB selective antibodies, phosphopeptides and phosphopeptide-specific antibodies, synthaloid AD drug discovery system, B-amyloid ELISA kits. Sealed and granted patents: Camaritto, Ca; Rockville, MD; Foster City, CA; Nivelles, Belgium.

490 BIOSPACE MESURES

Technological expertise: PA, C/TC, SY, RD, PIS, H/CF, HTDS, GA

Add: 10 Rue Mercoeur Paris 75011 France

Principal products/instrumentation: Cytokine ELISA Kits, secondary antibodies, cell biology antibodies, recombinant proteins, custom oligos, phosphorylation-state specific antibodies.

Fax: (33) 1-5525-6061

Main products/instrumentation under R&D: Cell biology antibodies, cell biology assays. Subsidiary bodies: Belgium.

Tel: (33) 1-5525-6060 E-mail: [email protected] Web site: www.biospace.fr President: Marie Meynadier Research director: Georges Charpak R&D expertise: Autoradiographic instrumentation. R&D collaboration: CEA.

489 BIOSOURCE INTERNATIONAL Add: 3 Avenue D Hopkinton, MA 01748-2215 Tel: (508) 435-2080; (800) 435-2080

Technological expertise: HTDS, Q, TE, CH/S Principal products/instrumentation: BetaImager, Micro Imager, BETA Vision, other instrumentation.

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Main products/instrumentation under R&D: Cardiac Imager, autoradiographic instruments.

Research director: C.C. Dawes, Ph.D.

Sealed and granted patents: More than 20.

R&D expertise: Protein development, manufacture & marketing globally; expansion of enzyme developments and R&D in affinity chromatography.

491 BIOSPACIFIC, INC. Add: 4240 Hollis St., Ste. 290 Emeryville, CA 94608 Tel: (510) 652-6155 Fax: (510) 652-4531 President/CEO: Sandy Koshkin Research director: Sandy Koshkin R&D expertise: Development and production of antibodies and antigens, especially in the cardiac and tumor marker areas. Joint ventures: FORTRAN BioScience, Inc. R&D collaboration: Fortron Bio-Science, Inc. Key sales market contracts: Fortron BioScience, Inc. Key license and trade contracts: DadeBehring (Troponin I Antibodies).

Subsidiary of Andard-Mount Co. Ltd.

Joint ventures: Scipac; Organics; Phil-Bio; Trakbio. R&D collaboration: Andard-Mount (Pacific) Ltd. Technological expertise: F, P/S, BA, C/TC, PMC, SY, Q, E Principal products/instrumentation: Menotropin; hCG; cellulose particles for affinity chromatography; Entest endotoxin test; Azadirachtin, natural pesticide; Camptothecin, taxol, oncolytic drug; a wide range of proteins, enzymes, alkaloids and steroids. Main products/instrumentation under R&D: Durus for penile impotence, Phase III clinical trials; 10 Hydroxycamptothecin as potential oncolytic; Euprenorphine, non-addictive analgesic for post-operative pain.

Technological expertise: PA, P/S Principal products/instrumentation: Antibodies to Cardiac Markers: Troponin I, CKMB, Myoglobin, GPBB, FABP. Tumor markers: PSA, Free-PSA, PSA/ACT Complex antigen, AFP, CEA, B-2 Microglobulin. Affinity purified polyclonals to TSH, FITC, Strep. A, lgE, hCG, Ferritin, troponin antibodies, complete antigen, tumor-specific antigen. Sealed and granted patents: Troponin I antibodies.

493 BIOSPEC PRODUCTS, INC. Add: P.O. Box 788 Bartlesville, OK 74005 Tel: (918) 336-3363; (800) 617-3363 Fax: (918) 336-6060 E-mail: [email protected] Web site: www.biospec.com President: T.R. Hopkins, Ph.D. Research director: T.R. Hopkins, Ph.D.

492 BIOSPECIA, LTD. Add: West Africa House, Ashbourne Rd. London, England W5 3QP UK Tel: (44) 81-991-5150 Fax: (44) 81-991-5001 President: Ian Gould, Ph.D.

R&D expertise: Development and manufacturer of biotech laboratory equipment. Technological expertise: P/S, BA, RD, F, E, GA, C Principal products/instrumentation: TissueTearor tissue homogenizer; Bead-Beater cell disrupter; BioHomogenizer tissue homogenizer; BioRotator rotator/rocker mixer;

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BioVortexer rnicrotube vortexer; Mini BeadBeater cell disrupter; tissue pulverizer; Bio Rotator rocker/rotator; BioPulverizer cryogenic cell disrupter, MicroMincer tissue press; BioDryer sample dryer; Micro BioFridge cooling block; TubeTickler microtube mixer; MicroMincer tissue press; BioDryer sample dryer; MicroBroFridge cooling block; TubeTickler microtube mixer, 2001; Multisample Cell Disrupter, 2007; other biotech laboratory equipment.

Principal products/instrumentation: ASM102U DNA Synthesizer, introduced from 1990; ASM-700 DNA Synthesizer, introduced from 1998; OPS-201 Oligonucleotides Purification System, DNA purification system.

Main products/instrumentation under R&D: Protein concentrator.

Add: 6655 Lookout Rd. Boulder, CO 80301

Sealed and granted patents: Oligonucleotides synthesis, DNA synthesizer.

496 BIOSTAR, INC.

Tel: (303) 530-3888 Fax: (303) 530-6601

494 BIOSPUR, INC.

President: Hank Pietraszek Research director: Lyndal Hesterburg, Ph.D.

Add: P.O. Box 170380 Milwaukee, WI 53217 Tel: (941)572-3703

R&D expertise: Development and production of infectious disease diagnostics.

Fax: (414) 355-1844

Technological expertise: P/S, C/TC

President: S. Bernstein

Principal products/instrumentation: Strep A OIA; Strep B OIA, diagnostic agent of infectious disease.

Research director: Melvin Bernstein R&D expertise: Development and manufacture of fermentation nutrients. Technological expertise: F, BA, E Principal products/instrumentation: Vegetable proteins, protein hydrolyzates, fermentation nutrients, essential nutrients.

497 BIO-STAT, LTD. Add: BIO-STAT House, Pepper Road Hazel Grove Stockport SKY 5BW UK Tel: (44) 0161-483-5884

495 BIOSSET, LTD.

Fax: (44) 0161-483-5778 E-mail: [email protected]

Add: Lavrentieva Ave., 8 Novosibirsk 630090 Russia

Web site: www.bio-stat.com

Tel: (7) 3832-32-0502

Research director: Yannick Schneider

Fax: (7) 3832-39-6225

R&D expertise: Development and production of diagnostic and research products.

Web site: www.biosset.com President/CEO: Yu. Sredin R&D expertise: Development and manufacture of purification system and analytical/ synthesis instruments. Technological expertise: PMC, R, SY, SI

President: Robert Isaacs, Chairman

Key sales market contracts: OXIS International, Maxim Biotech Inc., Biopool. Technological expertise: BME, BC, E, DK, ERT Principal products/instrumentation: Oxidative Stress Kits, OXIS; PCR, Maxim; Multiplex

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PCR, Maxim; Probes and primers, Maxim; diagnostic agents.

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Tel: (650) 367-4954 Fax: (650) 364-4985 Web site: www.biostride.com

498 BIOSTRATUM INCORPORATED Add: 4825 Creekstone Dr., Ste. 200 Durham, NC 27703 Tel: (919) 572-6515 Fax: (919) 544-5425 Web site: www.biostratum.com President/CEO: Dr. Claus Kuhl, MX., Ph.D. Research director: J. Wesley Fox, Ph.D. R&D expertise: Discovery, development and production of advanced therapeutics based on basal lamina technology. R&D collaboration: Joslin Diabetes Center, Karolinska Institutet (Sweden), University of Kansas Medical Center, R.W. J. Medical School, University of Minnesota, and the University of South Carolina. Key license and trade contracts: Shiseido/ Cutaneous Biology Research Center at Harvard Medical School. Technological expertise: SMC, R, D HTDS, GT Main products/instrumentation under R&D: Pyridorin — Post-Amadori AGE inhibitor for diabetic nephropathy, Phase II; Angiocol — anti-angiogenesis agent for cancer, Phase ??; Recombinant Laminins and Type IV Collagens — wound repair and tissue regeneration. Subsidiary bodies: Biostratum AB, Stockholm, Sweden. Sealed and granted patents: Nephrin gene and protein 7,105,291, U.S.

499 BIOSTRIDE, INC. Add: 1201 Douglas Ave. Redwood City, CA 94063

President: Laura Colin R&D expertise: Antibodies and enzymes research, relative products development. Technological expertise: RD, PIS, PA, P/S, RD Principal products/instrumentation: Free T-4 kit; antibodies/enzymes. Main products/instrumentation under R&D: Thyroid Rgt. Kits; novel antibodies and enzymes.

500 BIOSURFACE TECHNOLOGY, INC. Add: 64 Sidney St. Cambridge, MA 02139 Tel: (617) 494-8484 Fax: (617) 494-6561 President: David Castaldi Research director: Ross Tabo, Ph.D. R&D expertise: Therapeutic use research and development of cultured normal human cells for tissue replacement. R&D collaboration: Toho Pharmaceutical. Technological expertise: BA, C/TC Principal products/instrumentation: Cultured human epidermal autographs. Main products/instrumentation under R&D: Cultured human epidermal allografts, clinical trials; cultured chrondrocyte cells, cultured normal human cell.

501 BIOSYN ARZNCIMITTEL GMBH Add: Schomdorfer Strasse 32 Fellbach, Ra-Wu D-70734 Germany Tel: (49) 711-575-3200 Fax: (49) 711-575-3299

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Web site: www.biosyn.de President/CEO: Dr. Porcher Research director: Dr. Stiefel R&D expertise: Research of immunology, relative products, with a focus on products of immunomodulator development/manufacture. R&D collaboration: Biomira (immunocyanine (KLH)), Peptide Therapeutics (immunocyanine (KLH)). Key license and trade contracts: Madaus AG, Cologne and Fresenius AG. Technological expertise: Q, CB, D-D, H/CF, PIS, PMC, P/S, RD, ET Main products/instrumentation under R&D: Immucothel, immunocyanine, keyhole limpet hemocyanine in registration, Galasyn, Phase III/IV. Sealed and granted patents: Use of Hemocyanins and Arylphorins to influence the immune system and for the treatment of tumors — European patent: No. 0,320,528, USA patent: No. 5,231,081, Canadian patent: No. 1336322, Japanese patent: No. S 63318357/88; agent and method for the prevention of metastases of malignant tumors — European patent: No. 0,249,008, USA patent: No. 4,946,830, Japanese patent: No. 62113405.

502 BIOSYNERGY (EUROPE) LIMITED Add: 12 Pembroke Ave., Waterbeach Denny Industrial Centre Cambridge CB5 9PB UK

Technological expertise: BA, C/TC, F, H/CF, P/S Principal products/instrumentation: Recombinant proteins, monoclonal antibodies, other immunodiagnostics, products of cell and tissue culture. Subsidiary bodies: GMP manufacturing.

503 BIOSYN, INC. Add: 3401 Market St., Ste. 300 Philadelphia, PA 19104 Tel: (215) 387-5338 Fax: (215) 387-5332 E-mail: [email protected] Web site: www.biosyn-inc.com President/CEO: Anne-Marie Corner Research director: Richard Bax, M.D. R&D expertise: Women’s Health products, AIDS research, products development. R&D collaboration: NTCHD, N1AID, WHO. Technological expertise: AF Main products/instrumentation under R&D: Savvy C31G1.2% vaginal gel, microbicide, treat contraception, prevention of AIDS/HIV infection, infections disease, phase completed, 2008; Vaginal microbicide; Treatment for oral candidiasis, Phase II/III; Treatment of STDs, Preclinical; presumptive therapy for non-STD vaginal infections, preclinical. Sealed and granted patents: Over 40 worldwide.

Tel: (44) 1223-579345 Fax: (44) 1223-579349

504 BIOSYNTH AG

President/CEO: Robert J. Mason Research director: Dr. Dinesh A. Jacob R&D expertise: Contract R&D of immunodiagnostics and therapeutics, hybridoma technology research, contract production of biomolecules.

Add: Rietlistr. 4 Postfach 125 Staad 9422 Switzerland Tel: (41) 71-858-2020 Fax: (41) 71-858-2030 E-mail: [email protected]

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Web site: www.biosynth.com

Fax: (972) 420-0442

President: Hans Spitz

E-mail: [email protected]

Research director: G. Schabert, Ph.D.

Web site: www.biosyn.com

R&D expertise: Research, development, production and marketing of specialty chemicals like enzyme substrates, inducer and enhancer, detergents, culture media additives, culture media and indole derivatives.

President: Miguel Castro

Technological expertise: SY, E Principal products/instrumentation: Enzyme substrates, Indole derivatives. Main products/instrumentation under R&D: Specialty chemicals, culture media additives, inducer, enhancer, detergents. Subsidiary bodies: Biosynth International/ USA.

505 BIOSYNTHESIS Add: 612E. Main St. Lewisville, TX 75057

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Research director: Jessica Chen-Castro R&D expertise: Research and development of custom synthesis, chemical synthesis DNA/ peptides, DNA tissue typing, paternity testing, antipeptide antibodies, modified peptides and peptide instrumention. Technological expertise: PA, SY, CSDP, HDT, COS, S, CW, AB Principal products/instrumentation: Synthetic DNA, nonradioactive custom probes, synthetic peptides, antiserum production, chemiluminometers, custom peptides and antipeptide antibodies, long peptides, synthetic cytokines. Main products/instrumentation under R&D: HLA DNA typing products, long peptide synthesis, peptide modifications, peptidergic fiber, peptide synthesizer, peptide sequencer.

Tel: (972) 420-8505 Fax: (972) 420-0442 E-mail: [email protected] Web site: www. biosyn.com R&D expertise: Research of peptides and peptide instrumentation, related novel products development/manufacture.

507 BIOSYNTH INTERNATIONAL, INC. Add: 1665 W. Quincy Ave., Suite 155 Naperville, IL 60540 Tel: (630) 305-8400

Technological expertise: CW, CSDP, HDT, COS, PI, P, PIS, PPAT, P/PS, PS/AP

Fax: (630) 305-8420

Principal products/instrumentation: Custom produced peptides and antipeptide, antibodies, long peptides, synthetic cytokines.

Web site: www.biosynth.com

Main products/instrumentation under R&D: Peptide hormone, peptide library, peptide sequencer, peptide synthesizer, peptide-ELISA.

506 BIO SYNTHESIS

E-mail: [email protected] President: Hans Spitz R&D expertise: Markets products of Biosynth AG in North America; enzymes, enzyme substrates, plant growth regulators, etc. Key sales market contracts: Biosynth AG. Key license and trade contracts: R & F Laboratories. Technological expertise: P/S, SY

Add: 612 E. Main St. Lewisville, TX 75057 Tel: (800) 227-0627, (972) 420-8505

Principal products/instrumentation: Enzyme substrates (X-gal, X-gluc, BCIP, Luciferin,

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MUG, TMB, IPTG, etc.); Indole derivatives, pharmaceutical intermediates, plant growth regulators. Main products/instrumentation under R&D: Enzyme substrates, Enzyme inhibitor complex.

508 BIOSYS Add: 4520 East West Hwy., Suite 300 Bethesda. MD 20814-3347 Tel: (410) 381-2800 Fax: (410) 381-3844 President: Edwin C. Quattlebaum, Ph.D. Research director: Ramon Georgis, Ph.D. R&D expertise: Biological pest control research, pesticides development and production. R&D collaboration: Sandoz Agro, Inc. Key sales market contracts: Ciba-Geigy, Monsanto, Rhone-Poulenc, Sumitomo, SKS Biotech. Key license and trade contracts: USDA, Rutgers University. Technological expertise: F Principal products/instrumentation: Marketing pesticides: BioSafe; BioVector; Vector; Biosafe-N; Exhibit, Magnet, SanoPlant, Boden-Nutzlinge; Interrup; BioFlea Halt; Helix. Main products/instrumentation under R&D: Insect-killing baculoviruses, controlled release of pheromones and pesticides.

509 BIOSYSTEMS TECHNOLOGIES, INC. Add: P.O. Box 61742 Durham, NC 277151742 Tel: (919) 660-7413 President/CEO: Dr. Charles E. Magnuson

Research director: Dr. John D. Goeschl R&D expertise: Development and supply of advanced scientific techniques and products that help the development of plant new varieties, agricultural chemicals, and agricultural practices resulting in higher plant yields. R&D collaboration: Callahan Enterprises, division of Rhone-Poulenc Ag. Co. Technological expertise: CH/S Principal products/instrumentation: Plant physiological testing for environmental effects, chemical effects and basic research; Hybrid vigor screening techniques; BioSysTec testing. Main products/instrumentation under R&D: Flowering and fruit-set regulator identification.

510 BIOTAGE, A DIVISION OF DYAX Add: 1500 Avon St. Extended Charlottesville, VA 22902 Tel: (804) 979-2319 Fax: (804) 979-4743 E-mail: [email protected] President/CEO: Robert Dishman, Ph.D. R&D expertise: Development of low pressure and high pressure bench-top to manufacture scale LC systems for protein and peptide purification. Technological expertise: PIS, P/S, COC, HTDS, L, R, B, F, M, LP, RD, BA, F, PMC Principal products/instrumentation: Kiloprep HPLC systems, bench-top; Proprep sanitary protein LC systems; Unisphere alumina media and columns; prepacked silica cartridges for flash chromatography, Parallel Purification systems for combinatorial chemistry, low/high pressure benchtop, production scale LC system for protein/ peptide purification. Kiloprep lab-scale, pilotscale and production-scale HPLCs, Kiloprep prepacked cartridges. FLASH systems and cartridges, BIOFLASH cartridges, Parallex,

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HPLC parallex, HPLC parallel purification systems and cartridges.

Web site: www.biotal.co.uk

Subsidiary bodies: Hertford, England. Biotage UK Limited, A Division of Dyax Corp., 15 Harforde Court, John Tate Rd., Hertford UK, S613 7NW.

Research director: Stephen Mann, Ph.D.

511 BIOTA HOLDINGS LIMITED Add: 616 Kiloa Rd., Level 4 Melbourne, Vic 3004 Australia Tel: (61) 3-9529-2311 Fax: (61) 3-9529-2261 E-mail: [email protected] Web site: www.biota.com.au CEO: Hugh Niall Research director: Philip Reece R&D expertise: Research and development of human pharmaceuticals for treatments of viral diseases in respiratory system. R&D collaboration: Glaxo Wellcome; Blostar Inc. Key sales market contracts: Daichu Pure Chemicals; Pangio; Biostar. Principal products/instrumentation: Relenza; Flu OIA. Main products/instrumentation under R&D: Therapeutic drug for Rhinovirus, Preclinical; Therapeutic drug for RSV, Preclinical; Influenza virus vaccine; Phase I clinical trial of BT9881 for the treatment of respiratory syncytial virus in infants and adults, 2009.

512 BIOTAL, LTD. Add: 5 Chiltern Close Cardiff Industrial Park Cardiff, Wales CF4 5DL UK Tel: (44) 07-000-246825 Fax: (44) 01-222-766945 E-mail: [email protected]

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CEO: Rod Howe R&D expertise: Development and manufacture of products containing microbes and enzymes for agriculture, drug industry and consumers. Technological expertise: F, E, AF, BA, CB, PMC Principal products/instrumentation: Biotah Hay Inoculant; Biotal Silage Inoculant II; Biotal Plus; Super Sile; Super Hay; AxpHast; AxpHast Big Bale; Goldstore; PRO 90; Microcell; Biotal Biological Compost Maker; Biotal Grease Degrader; Biocharge. Main products/instrumentation under R&D: Feed enzymes; novel direct fed microbials; biological descaler. Sealed and granted patents: Use of microbe and enzyme formulations in forage and direct Fed products, stabilized liquid compost maker.

513 BIOTECH AUSTRALIA PTY, LTD. Add: 28 Barcoo St. Roseville, New South Wales 2069 Australia Tel: (61) 2-9928-8800 Fax: (61) 2-9928-8899 E-mail: [email protected] Web site: www.bioaust.com.au President/CEO: David E.F. Harrison, Ph.D. Research director: D.O. Irving, Ph.D. R&D expertise: Development and manufacture of recombinant DNA products for human and animal health. Contract or collaborative R&D and manufacturing of GMP recombinant proteins and antibodies. R&D collaboration: Hoechst: oral drug delivery; recombinant animal parasite vaccines. Key sales market contracts: Oxford Bioinnovations, clinical diagnostics.

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Key license and trade contracts: Cistron Biotechnology: rPAI-2.

Sealed and granted patents: U.S. Pat 5,543,023.

Technological expertise: F, P/S, Q, DD, HTDS, AB, RD, C Principal products/instrumentation: Neogard rDNA pig scours vaccine; Calfgard rDNA calf scours vaccine; Tickgard cattletick vaccine; Inhibm antibodies and tests, inhibin, PAI-2.

515 BIOTECH — IGG A/S Add: Oesterbrogade 95 Copenhagen DK-2100 Denmark Tel: (45) 3538-0500

Main products/instrumentation under R&D: Folistatin, Inhibin tests for cancer; Human PAI-2, oral drug development delivery route, recombinant animal parasite vaccines.

Fax: (45) 3538-7322

Sealed and granted patents: PAI-2; Oral Drug Delivery; Folistatin.

President: Alistair Hurst

514 BIOTECH HOLDINGS — GELUX, INC. Add: 245 E. Tallmadge St. Akron, OH 44310 Tel: (330) 376-9090 Fax: (330) 376-9050 E-mail: [email protected]

E-mail: [email protected] Web site: www.biotech-igg.dk R&D expertise: Biotechnology applied research and, medical diagnostics development in the Nordic countries (Denmark, Sweden, Norway, Finland and Iceland). Technological expertise: COC, C/TC, BA, F, PA, RD, P/S, PMC, CH/S Principal products/instrumentation: Biologicals, contract research/clinical trial products, diagnostics, enzymes, instrumentation, vaccines, antibodies.

Web site: www.biotechholdings.com President: Peter Lugojan, Ph.D. R&D expertise: Development of precast gels (custom), bioanalytical labs research and relevant, products manufacture.

516 BIOTECH INSTRUMENTS, LTD. Add: Biotech House 75A High St. Kimpton, Hertfordshire SG4 8PU UK

Joint ventures: LL Biores Labs — Bucharest, Romania.

Tel: (44) 1438-832555

R&D collaboration: Chemicon (USA), Biorad (USA), Pharmacia (USA), Amresco (USA).

E-mail: [email protected]

Fax: (44) 1438-833040

Technological expertise: E, P/S

President: Ray Newton, Ph.D.

Principal products/instrumentation: Custom precast gels, Gelux; IEF Gels (Vertical and horizontal), IEF-Gelux; Collagen Type II — Chicken Sternae, Colanet; Latex protein testing, Prolatex.

R&D expertise: In vivo drug metabolism research, peptide drugs synthesizer manufacture.

Main products/instrumentation under R&D: IEF Ultrathin Plates (Ready to market).

Technological expertise: SM, CS, P/S Principal products/instrumentation: BT 7400 Multiple Peptide Synthesizer, peptide in vivo metabolic route.

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517 BIOTECH INTERNATIONAL, LTD.

R&D expertise: Molecular biology research and relative novel products manufacture.

Add: 14B Brennan Way Belmont Perth, WA 6104 Australia

Technological expertise: RD, P/S, GA, H/CF, C/TC, CH/S, SY, Q

Tel: (61) 8-9478-4735

Principal products/instrumentation: DNA/ RNA Extra-Sep extraction kit.

Fax: (61) 8-9478-4759 E-mail: [email protected] Web site: www.biotech.com.au

Main products/instrumentation under R&D: DNA probes, DNA primer, DNA purification kits.

President: David Fawcett Research director: Dr. Robert Dunlop R&D expertise: Research, development and production of biotechnology drug products. Joint ventures: Esvin Biosys International Ltd.

519 BIOTECH M.A.H. Add: Shalem Farm-Headquarters Brurim M.P. Shikmim 79837 Israel Tel: (972) 03-631-9192

Key license and trade contracts: Hoffman La-Roche: PCR technology.

Fax: (972) 03-631-4114

Technological expertise: E, F, GA

Web site: www.main.co.il

Principal products/instrumentation: Thermastable PCR enzymes, TaqFl; D-dimer diagnostic test kits, Dimertest Gold, AutoDimertest; Veterinary diagnostic test kits, VetRed, Witness; Infectious diseases diagnostic test kits, SimpliRed.

Research director: Dr. Berthold (tolo) Friedland

Main products/instrumentation under R&D: Xylanase enzyme, commercialization development. Subsidiary bodies: ISO9001-TGA-Acacia Ridge, Brisbane, Australia; IS9002, Belmont, Australia.

E-mail: [email protected]

R&D expertise: Development of agrochemicals, intermediates and environmental technologies; Bacterial formulation for treating petroleum contamination of both fresh and salt water; New biomatrix for heavy metals removal from contaminated water; Lycopene extract from tomatoes, etc. Technological expertise: E, CW, BI Main products/instrumentation: Contaminated water management system, drug inter mediates, lycopene extract technique.

518 BIOTECH ITALIA 520 BIO-TECHNICAL RESOURCES Add: Via Delia Marcigliana 532 Rome 00139 Italy

Add: 1035 S 7th St. Manitowoc, WI 54220

Tel: (39) 6-8712-1056

Tel: (920) 684-5518

Fax: (39) 6-8712-2353

Fax: (920) 684-5519

President: Fernando Macchitella

E-mail: [email protected]

Research director: Stefano Vella

Web site: www.biotechresources.com

Subsidiary of Genescience Inc.

President: Tom Jerrell

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Research director: Reinhardt A. Rosson, Ph.D.

Tel: (31) 35-699-2595

R&D expertise: Process new technologies developed based on microbial fermentation and biocatalysis.

Fax: (31) 35-694-9576

Key sales market contracts: Rhein Biotech for Hansenula Polymorpha Expression System; Gist-Brocades for Bacillus Licheniformis Expression System. Technological expertise: BA, E, F, GA, P/S, RD, Q, SY Principal products/instrumentation: Agriculture, biological, biomass, bioremediation, biosensors, chemicals, contract research products, pesticides, pharmaceuticals, enzymes, antibiotics. Main products/instrumentation under R&D: Hansenula polymorpha expression system, Bacillus licheniformis expression system.

521 BIOTECHNOLOGIE GERMFREE LABORATORIES, INC. Add: 7435 NW 41st St. Miami, FL 33166 Tel: (800) 888-5357 Fax: (305) 591-7280 E-mail: [email protected] Web site: www.germfree.com President/CEO: Dr. Jerome Landy R&D expertise: Development and manufacture of process control equipment for pharmaceutical, biotechnology and laboratory applications.

E-mail: [email protected] Web site: www.bac.nl President: E. Veltkamp Research director: Dr. A. Baan Subsidiary of Unilever. R&D expertise: Production and development of industrial proteins by micro-organisms on pilot plant sale. Technological expertise: BI, BA, CH/S, E, F, GA, PIS, PA, PMC, P/S Principal products/instrumentation: Biological, contract manufacturing products, contract research products, detergents, diagnostics, food processing products, industrial proteins.

523 BIO-TECHNOLOGY GENERAL CORP. Add: 70 Wood Avenue South Iselin, NJ 08830 Tel: (908) 632-8800 Fax: (908) 632-8844 Web site: www.btgc.com President: Virgil Thompson Research director: Dr. Amos Panet

Technological expertise: G, GA, BME

R&D expertise: R&D, manufacture and marketing of genetically engineered drugs and other human therapeutics with a focus on endocrine drugs.

Principal products/instrumentation: Laminar Flow Biological Safety Cabinets, Glove Boxes, Custom Filtration and Containment Systems for the Genetic Engineering field.

Key sales market contracts: JCR Pharmaceuticals Co. — Human Growth Hormone for Japan; Far East — Scitech Medical Products — Human Growth Hormone; Hepatitis B Vaccine.

522 BIOTECHNOLOGY APPLICATION CENTRE (BAC BV) Add: Huizerstraatweg 28 1411 GP Naarden Netherlands

Key license and trade contracts: Merck Frosst (Canada) Inc. — Thrombus Imaging Agent (Worldwide). Technological expertise: F, P/S, RD, G, RPP Principal products/instrumentation: BioTropin (Somatropin, human growth hormone,

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rDNA origin) for the treatment of childhood growth development retardation; Biolon (sodium hyaluronate) for ophthalmic surgery; Delatestryl (injectable testosterone); Bio-HepB (hepatitis B vaccine).

Tel: (852) 2358-7290

Main products/instrumentation under R&D: OXSODROL (recombinant human superoxide dismutase) for the treatment of asthma and bronchopulmonary dysplasia; OxSODROL Phase II; BioHy (sodium hyaluronate) Phase III/IV; Insulin (recombinant human insulin) Phase III/IV; Faaorex (anti-coagulant) Preclinical; Puricase (Peg-Uri case) Preclinical.

President: Prof. Nancy Ip

Sealed and granted patents: Human manganese superoxide dismutase DNA, its expression and method of recovering human manganese superoxide dismutase, 6,361,772, U.S.

524 BIOTECHNOLOGY GENERAL (ISRAEL), LTD. Add: Science-Based Industrial Park Kiryat Weizmann Rehovot 76326 Israel

Fax: (852) 2358-1552 E-mail: [email protected] Web site: www.ust.hk/~bri Research director: Dr. Lisa Chao R&D expertise: Basic and applied research projects with industry and research institutions both internationally and regionally. Technological expertise: F, Q, BI, C/TC, COC, DD, HTDS Principal products/instrumentation: Contract research products, cell/tissue culture products, vaccines, enzymes, antibodies, reagents, etc.

526 BIOTECH SOLUTIONS, INC. Add: One Carnation Ct, Ste. B Mt. Laurel, NJ 08054 Tel: (856) 231-0559

Tel: (972) 8-381122

Fax: (856) 787-9815

Fax: (972) 8 409041

E-mail: [email protected]

R&D expertise: Development and manufacture of human growth hormone, hyaluronic acid, bovine somatotropin, porcine growth hormone. HBV vaccine, human superoxide dismutase and Vitamin D derivatives.

Web site: www. biotechsolutions.org

Technological expertise: BP, PC Principal products/instrumentation: Contract R&D products. Main products/instrumentation under R&D: Human growth hormone, bovine somatotropin, HBV vaccines, human superoxide dismutase.

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President: Janet F. Cohen Research director: James G. Finneran R&D expertise: Research of related products for drug discovery drug design, drug development and combinatorial chemistry. Technological expertise: DD, COC, DDI Principal products/instrumentation: Well multi-tier microliter plate (patent pending).

527 BIOTECON DIAGNOSTICS, GMBH 525 BIOTECHNOLOGY RESEARCH INSTITUTE (BRI) Add: Hong Kong University of Science & Technology, Clear Water Bay. Kowloon Hong Kong

Add: Tegeler Weg 33 Berlin 10589 Germany Tel: (49) 30-34-607-500 Fax: (49) 30-34-607-600 E-mail: [email protected]

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Web site: www.bc-diagnostics.com

Tel: (713) 643-0606

CEO: Dr. Konni Berghof

Fax: (713) 643-3143

Research director: Dr. Konni Berghof

E-mail: [email protected]

R&D expertise: Development, design, production and supply of PCR and ELISA kits for detection of microbial pathogens and spoilage of organisms in food and the detection of genetically modified organisms in food.

Web site: www.biotecx.com

Joint ventures: Roche Technological expertise: C/TC, DD, E, F, PA, P/S, RD Principal products/instrumentation: Foodproof salmonella; foodproof Listeria. Main products/instrumentation under R&D: Lightlycler; foodproof GMO.

528 BIOTECON GMBH Add: Hermannswerder 17 Potsdam D-14473 Germany Tel: (49) 331-23000 Fax: (49) 331-2300100

President: Mohan Mehra, Ph.D. R&D expertise: Research and development of molecular biology, isolation kits for RNA/ DNA, immunology, cell biology and diagnostics; relative applied products manufacture. Technological expertise: P/S, C/TC, T Principal products/instrumentation: Molecular biology products for the isolation of RNA, mRNA, simultaneous RNA/DNA, genomic DNA, plasmid DNA & lambda phase DNA. Immunology products including T-Cell, B-Cell and T-Cell subpopulation kits for the purification of rat, mouse, human, cat, dog and monkey T-Cell, CD4 & CD8. Immunodiagnostic products including RIA and ELISA kits for testing hormones, teriods, tumor markers and infectious diseases, molecular biology grade specialty chemicals.

E-mail: [email protected] Web site: www.Biotecon.com

530 BIO-TEK INSTRUMENTS, INC.

CEO: Kornelia Berghof Ph.D. Research director: Kornelia Berghof, Ph.D. Subsidiary of AnalytiCon AG

Add: Highland Park, Box 998 Winooski.VT 05404

R&D expertise: Development and manufacture of PCR based kits for food testing.

Tel: (802) 655-4040

Technological expertise: F, GA, PMC, P/S, RD

E-mail: [email protected]

Principal products/instrumentation: Bio melanin, biomaterials, contract research products, biopharmaceuticals.

Web site: www.biotek.com

Main products/instrumentation under R&D: PCR Kit for pathogen microorganism detection, PCR kit for food testing.

Fax: (802) 655-7941

President/CEO: Briar Alpert R&D expertise: Research, design, development and marketing of biomedical and laboratory instruments, software and integrated system solutions. Technological expertise: CH/S, HTDS, R

529 BIOTECX LABORATORIES, INC. Add: 6023 S. Loop East Houston, TX 77033

Principal products/instrumentation: Biotechnology instruments including powerwave, microplate spectro photometer; ELx405 Select

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96/384 Well Microplate Washer, Multidetection microplate reader, 2007; Gen5 Microplate Data Analysis Software, 2007.

531 BIOTEST DIAGNOSTICS CORP. Add: 66 Ford Rd., Suite 131 Denville, NT 07834 Tel: (973) 625-1300 Fax: (973) 625-5882 Web site: www.biotest.com President: Dr. Harro Walger

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Principal products/instrumentation: Biothane Upflow Anaerobic Sludge Blanket, UASB; Biobed Expanded Granular Sludge Bed, EGSB; High Rate Compact Reactor, HCR. Subsidiary bodies: Biothane Canada, Michael M. Safty, 95 Arbour Dr., Oakville, Ontario, L6J 4Y6, Tel: (905) 842-9451, Fax: (905) 8429448; Techno logia Intercontinental SA de C.V., Rio Lerma 171-4, Mexico City, Mexico 06500, Tel: (525) 514-0321, Fax: (525) 511-6570. Sealed and granted patents: UASB and EGSB technologies.

Research director: Dan Behler R&D expertise: Development, manufacturer and supply of microbial air monitoring devices, air borne particle counters, and biological indicators.

Add: Tykistokatu 6 Turku FIN-20520 Finland

Technological expertise: PMC

Tel: (358) 2-274-8544

Principal products/instrumentation: Hycon — 1990.

Fax: (358) 2-274-8910

Main products/instrumentation under R&D: Microbial air monitoring devices, borne particle counters, biological indicators.

President/CEO: Markku Jalkanen

533 BIO THERAPIES CORP.

Web site: www.biotie.com Research director: Timo Veromaa R&D expertise: R&D of biotech Pharmaceuticals, novel products manufacture.

532 BIOTHANE CORPORATION Add: 2500 Broadway/Dwr. #5 Camden, NJ 08104 Tel: (609) 541-3500 Fax: (609) 541-3366 E-mail: [email protected] Web site: www.biothane.com President: Robert I. Sax, Ph.D. Research director: Jelte Lanting

Joint ventures: Inalco S.P.A. (Italy). R&D collaboration: Boehringer Ingelheim Pharma KG (Germany). Technological expertise: F, SMC, BA, S, C/TC, H/CF Main products/instrumentation under R&D: Vepalimomab/monoclonal antibody, Phase II/III; Bioheparin, preclinical; biorepressor biotherapeutics. Sealed and granted patents: Several.

Subsidiary of Joseph Oat Corp. R&D expertise: Research and manufacture of high rate anaerobic wastewater pretreatment for pharmaceutical, biochemical applications.

534 BIOTHERAPY SYSTEMS Add: Lauggewann 63 Heidelberg 64727 Germany

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Tel: (49) 622-7143-6874 Fax: (49) 622-7140-7308 E-mail: Dr. [email protected] President: Manuela Ahlert Research director: Thorsten Ahlert R&D expertise: Research and development of tumor vaccines, immunodiagnostics, cell tissue banking and virology.

Main products/instrumentation under R&D: Vepalimomab/monoclonal antibody, Phase I/II; Bioheparin, preclinical. Sealed and granted patents: DNA sequence encoding, a novel glucuronyl C5-epimerase, 6,764,844, U.S.; several patents are pending.

536 BIOTIME, INC.

R&D collaboration: Public research institutes. Key license and trade contracts: Tumor vaccine ATV-NDV.

Add: 935 Pardee St. Berkeley, CA 94710

Technological expertise: P/S, BS, C/TC, CH/S

Fax: (510) 845-7914

Principal products/instrumentation: Contract manufacturing products, organ transplants/culture products, vaccines, ATV-NDV autologous tumor vaccine virally modified.

Web site: www.biotimeinc.com

Main products/instrumentation under R&D: Dendritic cell vaccines export system tumor immunomonitoring (clinical Phase II/III); therapy monitoring neuronal networks.

R&D expertise: Research and development of several biotechnology medicines.

Sealed and granted patents: Newcastle disease virus-modified dendritic cell vaccine.

535 BIOTIE THERAPIES CORP. Add: Tykistokatu 6 Turku FIN-20520 Finland Tel: (358) 2-274-8544 Fax: (358) 2-274-8910 E-mail: [email protected]

Tel: (510) 845-9535 E-mail: [email protected] President: Ronald S. Barkin Research director: Hal Sternberg

Key license and trade contracts: Abbott Laboratories has an exclusive license to manufacture and market Hextend, BioTime’s first product in North America. Abbott has right of first refusal on other BioTime products. Principal products/instrumentation: Hexten. Main products/instrumentation under R&D: PentaLyte, Phase II; Hetacool, Phase I. Sealed and granted patents: 10 patents issued in the U.S. alone covering Hextend and PentaLyte. PCT application has been favorably received.

Web site: www.biotie.com President/CEO: Markku Jalkanen Research director: Timo Veromaa R&D expertise: Research and development of biotech and pharmacuticals. Joint ventures: Inalco S.P.A. (Italy). R&D collaboration: Boehringer Ingelheirn Pharma KG (Germany). Technological expertise: BA, CB, C/TC, F, H/CF, P/S, RD, SMC

537 BIOTOOLS, B&M LABS, S.A. Add: General Peron-2 Madrid 28020 Spain Tel: (34) 915-711660 Fax: (34) 915-711232 E-mail: [email protected] President: Pedro M. Franco de Sarabia Research director: Francisco Martin

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R&D expertise: Development and manufacture of kits and reagents for research and diagnosis in life sciences.

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Main products/instrumentation under R&D: Bioinformatics software, data mining and manipulation; also MRD.

Joint ventures: Uniscience do Brasil, Sao Paulo. R&D collaboration: Centro de Biologia molecular (Madrid, Spain), Instituto de Biomedicina (Valencia, Spain), Medicina Legal, (Madrid, Spain). Technological expertise: CH/S, GA, G, P/S, RD, R, Q, T Principal products/instrumentation: Nuclear acids purification kits, Bioclean, et al.; viral detection kits, Bioherp; food analysis kits, Biofood; thermostable enzymes and reagents, Biotools, et al.; diagnostic kits.

538 BIOTOOLS INCORPORATED

539 BIOTOP GMBH Add: Stockhumer Strasse 28, Building A7/1 Witten, NRW 58453 Germany Tel: (49) 2302-914400 Fax: (49) 2302-9144010 E-mail: [email protected] Web site: www.bitop.de President: Dr. Thomas Schwarz Research director: Dr. Thomas Schwarz R&D expertise: Research of enzymology, enzymatic technique and recombinant DNA scale-up and purification/separation; relative novel products manufacture.

Add: 420 Sunlife Place 10123 99 Street Edmonton, Alberta T5J 3HI Canada

Key sales market contracts: Biomol GmbH, Fermentas AB.

Tel: (780) 423-1133

Key license and trade contracts: Merck KGaA.

Fax: (780) 423-1333

Technological expertise: E, F, P, B, R

E-mail: [email protected]

Principal products/instrumentation: Ectocrine, hydroxycetoine, BioStab (Antibody), BioStab (Enzyme).

Web site: www.biotools.com President/CEO: Gordon Stranks Research director: Dr. David Wishart R&D expertise: Bioinformatics research, biotechnological contractual software and database development, custom peptide synthesis.

Main products/instrumentation under R&D: Highly efficient periplasmatic expression of recombinant proteins by using ectoines. Sealed and granted patents: Bacteria milking.

R&D collaboration: Varian. Key license and trade contracts: Sawady Technology Co. Ltd. (Japan); Lifescience Software Resource (USA). Technological expertise: S, PIS, SY, CH/S, BI Principal products/instrumentation: GeneTool (DNA sequence analyzer), PepTool (protein sequence analyzer) ChromaTool (chroma analyzer) Operating System: M, P, R, Protein sequence analysis software; DNA sequence analysis software.

540 BIOTRANSPLANT, INC. Add: Building 75, Third Ave. Charlestown Navy Yard Charlestown, MA 02129 Tel: (617) 241-5200 Fax: (617) 241-8780 E-mail: [email protected] President/CEO: Elliot Lebowitz, Ph.D. Research director: Julia Greenstein, Ph.D.

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R&D expertise: Research, development and manufacture of biotechnology medicines and biomedical treating system. R&D collaboration: Sandoz Pharma Ltd., Novartis, Medimmune. Technological expertise: C/TC, GT, P/S, RD, Q, T Principal products/instrumentation: Biologicals, organ transplants/culture products. Main products/instrumentation under R&D: AlloMune System, Allograft transplantation system, preclinical; XenoMune System, Xenograft transplantation system, research; MED-507, Monoclonal antibody for treating GVH, Phase II; Allomune humanized anti-CD2 MAB, treat refractory non-Hodgkin’s lymphoma or Hodgkin’s disease, Phase I/II, 2008. Sealed and granted patents: Gamma-herpes virus DNA and methods of use, 6,461,811, U.S.

541 BIOTRIN INTERNATIONAL Add: 93 The Rise Mount Merrion Dublin Ireland Tel: (353) 1283-1166 Fax: (353) 1283-1232 E-mail: [email protected] Web site: www.biotrin.ie/biotrin President: Dr. Cormac G. Kilty Research director: Dr. Sean Doyle R&D expertise: Research, development and manufacture of in vitro diagnostic test kits for organ damage and viruses. Key license and trade contracts: University of Leiden — Parvo B19, Trinity College Dublin — Serum Amyloica, Bioscience/ Boston University — Trypsinogen activation peptide. Technological expertise: P/S, C/TC, GA, PA, RD

Principal products/instrumentation: In vitro toxicology testing products, organ transplants/culture, Parvovirus B19 tests; Glutathione, S-transferase; GST. Main products/instrumentation under R&D: Tests for bile duct damage in humans, tests for monitoring of pig xenotransplants, assay to detect trypsinogen activation peptide. Subsidiary bodies: Biotrin SAUL, 14 rue Gorge de Loup, 69 009 Lyon, France; Biotrin GmbH, 16 Wie Scustrabe 74889, Sinsheim, Germany.

542 BIOTROL, INC. Add: 326 Shady Lane Alvaton. KY 421229709 President: Michael S. Gratz Research director: Dennis D. Chilcote, Ph.D. R&D expertise: Hazardous chemicals treatment of contaminated soil and water by offering systems and services to industrial site owners, consultants, contractors and regulatory agencies as full-service systems. Technological expertise: F, P/S, BA Principal products/instrumentation: BioTrol Aqueous Treatment System (BATS), a fixed-film bioreactor for detoxification of organic chemicals in water; BioTrol Soil Treatment System (BSTS), a soil washing system using water as the scrubbing agent to concentrate chemical contaminants from soil as a pretreatment to detoxification; BioTrol In Situ Treatment (BIST) for the management of underground microbiological systems to detoxify migrating organic chemicals; BioTrol Solid Phase Biotreatment (BSPT) of excavated solids with organic compounds; and EZ-Tray Low Profile Air Stripper for removal of volitile contaminants from groundwater. Main products/instrumentation under R&D: Trichloroethylene (TCE) detoxification using methanotrophic bacteria, pilot scale demonstration.

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543 BIOVATION Add: Crombe Lodge, Aberdeen Science Park Bargaunie Dr. Aberdeen AB22 8GU UK Tel: (44) 0-1224-707337 Fax: (44) 0-1224-708816

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signal transduction reagents, antibodies, vaccines, enzymes, peptides.

545 BIOWHITTAKER, INC.

E-mail: [email protected]

Add: 8830 Biggs Ford Rd. Walkersville, MD 21793-0127

Web site: www.biovation.co.uk

Tel: (301) 898-7025

CEO: Dr. Frank J. Carr

Fax: (301) 845-4024; (301) 845-8338

Research director: Dr. Anita A. Hamilton

E-mail: [email protected]

R&D expertise: Research, development and relative products manufacture of antibody and protein engineering.

Web site: www.biowhittaker.com

R&D collaboration: Tanox, Inc., Vectura Ltd., Agen Biomedical Ltd., B2L Biologics. Technological expertise: D-D, AB, PC Main products/instrumentation under R&D: Anti-DNA antibody, hybrid antibody, amyloid A protein, carrier protein. Sealed and granted patents: Delmmunisation family of patents; Biodisplay family of patents.

544 BIOVISION, INC. Add: 450 San Antonio Road, Suite 27 Pal Alto, CA 94306 Tel: (650) 424-1315 Fax: (650) 424-1316 E-mail: [email protected] Web site: www.biovision.inc.com President/CEO: Gordon Yan Research director: Gordon Yan R&D expertise: Research and development of biotechnology medicines for life science research market.

President: Noel Buterbaugh Research director: Dr. Ronald Berzofsky Subsidiary of Cambrex Corp. R&D expertise: Research, development, manufacture and marketing of cell culture products, cell biology products and endotoxin detection products, large animal antibody biotechnology supplies, molecular biology, cell culture media for industrial applications. Scale-up partner: PerImmune Technological expertise: C/TC, GT, H/CF, BA, F, TE Principal products/instrumentation: Clonetics normal human cell systems, cell culture products, cell culture media, sera and reagents, serum free media, micronized powdered media, fetal bovine serum, molecular biology buffers and reagents, endotoxin test kits, cell cultures for virus isolation and identification, viral reagents, allergy diagnostics tests, biologicals, monoclonal antibodies, single cell proteins. Subsidiary bodies: Bio Whittaker UK, Bio Whittaker Europe.

546 BIOWHITTAKER MOLECULAR APPLICATIONS, INC.

Technological expertise: C/TC, PA, RD Principal products/instrumentation: Apostosis detection kits, apostosis research reagents,

Add: 191 Thomaston St. Rockland, ME 04841 Tel: (207) 594-3400

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Fax: (207) 594-3426

548 BIOZYME LABORATORIES, LTD.

E-mail: [email protected] President: Milton Steele

Add: Gilchrist Thomas Estate, Unit 6 Blaenavon, Gwent, South Wales NP4 9RL UK

Research director: Dr. Noriko Kusukawa

Tel: (44) 1495-790678

Subsidiary of FMC Corporation

Fax: (44) 1495-791780

R&D expertise: Research of molecular separations and electrophoresis, relative` products development.

E-mail: [email protected]

Principal products/instrumentation: Natural products, reagents, Agarose, Seakem; sequence gels; Long Ranger.

Subsidiary of Enviromed plc

Web site: www.bioproducts.com

547 BIOZYM DIAGNOSTIK GMBH Add: Postfach 180 Steinbrinksweg 27 Hessisch Oldendorf, Lower Saxony 31833 Germany Tel: (49) 5152-9020 Fax: (49) 5152-2070 E-mail: [email protected] Web site: www.biozym.com President: Winfried Duven, Kurt Welk Research director: Dr. Siegfried Hauch R&D expertise: Development and marketing of medical and pharmaceutical products of own and foreign manufacturing in the field of molecular biology and biomedicine. Joint ventures: Memorec Stoffel GmbH. Key sales market contracts: Memorec Stoffel GmbH. Technological expertise: CH/S, GA, GT, P/S, RD, R, Q, G, HTDS Principal products/instrumentation: Plastics, reagents, sterile filter tips; disposables; pipettors, Precision; thermal cycler, MultiCycler; sequenzer, chip-scanner, PIQOR cDNA arrays; DNA-arrayer. Subsidiary bodies: Biosym Austria, Vienna.

Web site: www.biozyme.com President: John Chesham, Ph.D. R&D expertise: Development and production of highly purified enzymes for clinical diagnostics, immunodiagnostics and biotechnology research. Technological expertise: E, P/S, ET Principal products/instrumentation: Diagnostics, reagents, biologicals, contract manufacturing products, biosensors, alcohol dehydrogenase, alkaline phosphatase, cholesterol esterase, glucose oxidase, ultrapure enterokinase, peroxidase, ribonuclease trypsin inhibitor, urease, catalase, elastase, hyaluroxidase. Subsidiary bodies: Biozyme Laboratories Int’l, Ltd., 9939 Hibert St., Suite 101, San Diego, CA 92131, Tel: (858) 549-4484; Fax: (858) 549-0138.

549 BIRD ENGINEERING B.V. Add: De Brauwweg 13 Schiedam 3125 AE Netherlands Tel: (31) 10-415-7822 Fax: (31) 10-437-9648 E-mail: [email protected] Web site: www.birdengineering.nl President: Dr. J. P. van Djken Research director: Dr. J. P. van Djken R&D expertise: Consultancy, bioprocess engineering and contract research, engineering and

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recruitment for the bio (process) technological industry.

Tel: (610) 993-9758

R&D collaboration: Delft University of Technology.

E-mail: [email protected]

Key license and trade contracts: Delft University of Technology. Technological expertise: AF, BI, BA, C/TC, CH, P/S, RD, LP, education, recruitment of personnel for biotechnology jobs. Principal products/instrumentation: Biological, antibiotics, single cell proteins, vaccines, enzymes, and monoclonal antibodies.

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Fax: (610) 695-9388 President: June Bossinger, Ph.D. R&D expertise: Development and manufacture of biomedical software. Technological expertise: P/S, BI, CH/S Principal products/instrumentation: BioAlmanac; Biomedical CD-ROMs, CD-ROMrelated computer hardware.

552 BLUE MARBLE RESEARCH, INC. 550 BISEPS, INC.

Add: 69 S. Manning Blvd. Albany, NY 12203

Add: 25330 SE 36th Ct. Issaquah, WA 98029

Tel: (518) 438-5050

Tel: (425) 837-0398

President: Richard G. Cohn-Lee

Fax: (425) 837-0697

R&D expertise: Development and production of pharmaceuticals, nutraceuticals and environmental remediation (basic research).

E-mail: [email protected] Web site: www.biseps.com President/CEO: Andrew R. Alaska, Ph.D. Research director: Andrew R. Alaska, Ph.D. R&D expertise: Development and manufacture of low-pressure chromatography. R&D collaboration: Ellard Instrumentations Ltd.; Drewe and Associates, Inc. Technological expertise: P/S, BA, BME Principal products/instrumentation: Side pack columns “Biseps”. Main products/instrumentation under R&D: Sorbent matrices for preparative chromatography, R&D; low-pressure chromatography. Sealed and granted patents: 5,667,676 “Side Pack Column” issued on September 16, 1997.

551 BLUE LIGHTNING DATA AND SOFTWARE, INC. Add: 30 S. Valley RD, Suite 310 Paoli, PA 19301-1476

Technological expertise: CC, Z, D, E, SMC, CB, C/TC, DD, P/S, and D-D Principal products/instrumentation: Biosensors, cosmetics, detergents, diagnostics, food processing, instrumentation, natural products, nutraceuticals, pharmaceuticals, plastics, and vaccines. Main products/instrumentation under R&D: Non-invasive glucometry, preclinical; Noncalorie fat substitutes for frying, preclinical; Oral anti-HTV vaccine, preclinical. Sealed and granted patents: Anti-HIV compounds; non-invasive glucometry.

553 BLUE MOUNTAIN QUALITY RESOURCES Add: 208 W. Hamilton Ave, State College, PA 16801 Tel: (800) 982-2388 Fax: (814) 234-7077

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E-mail: [email protected]

Technological expertise: COC, HTDS, R

Web site: www.coolblue.com

Principal products/instrumentation: Diagnostics, pharmaceuticals, FLUOstar microplate fluorometer; LUMIstar microplate luminometer; POLARstar fluorescense polarization in microplates.

President: James Erickson R&D expertise: Research, development and manufacture of calibration management software. Technological expertise: CH/S, AU

Main products/instrumentation under R&D: NEPHELOstar microplate nephelometer.

Principal products/instrumentation: Calibration Manager™ software.

Subsidiary bodies: Germany, France, UK.

554 BMG LABTECHNOLOGIES Add: Hanns-Martin-Schleyer — Str. 10 Offenburg 77656 Germany Tel: (49) 781-969680 Fax: (49) 781-969867 Web site: www.bmg-labtechnologies.com President: Dr. Thomas Rabiger

556 BMG LABTECHNOLOGIES, LTD. Add: P.O. Box 73 Aylesbury, Bucks HP20 2QJ UK Tel: (44) 012-9633-6650 Fax: (44) 012-9633-6651 E-mail: [email protected] Web site: www.bmg-labtechnologies.com

Research director: Dr. Thomas Rabiger

R&D expertise: Research, development and manufacture of biomedical products.

R&D expertise: Development and production of microplate readers.

Technological expertise: BA, C/TC, D-D, AF, P/S, PI/S, BI

Technological expertise: HTDS, BME

Principal products/instrumentation: Organ transplants/culture products, reagents FLUOstar; LUMIstar; NEPHELOstar.

Principal products/instrumentation: Biological, pharmaceuticals, reagents and instrumentation. Principal products/instrumentation: Multidetection microplate reader, Polarstar, Galaxy.

Main products/instrumentation under R&D: Galaxy.

557 BOECKELER INSTRUMENTS, INC. 555 BMG LABTECHNOLOGIES, INC. Add: 2415 Presidential Bldg.204, Dr. 118 Durham, NC 27703-8026

Add: 4650 South Butterfield Dr. Tucson, AZ 85714 Tel: (520) 745-0001

Tel: (919) 682-1228

Fax: (520) 745-0004

Fax: (919) 682-1673

E-mail: [email protected]

E-mail: [email protected]

Web site: www.boeckeler.com

Web site: www.bmg-labtechnologies.com

President/CEO: Arvie Lake

R&D expertise: Robotics research and relative products development, engineering products manufacturing and marketing.

R&D expertise: Development and manufacture of precision metrology instruments and video imaging systems.

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Key sales market contracts: Marzhauser Wetzlar GmbH Co. KG — microscope stages, measuring stages, and micromanipulators.

Main products/instrumentation under R&D: Viral polymerase inhibitor, mammalian cell culture.

Technological expertise: CH/S, R

Subsidiary bodies: Boehringer Ingelheim Pharma KG, Biberach, Germany; the largest biotechnical operation for mammalian cell culture in Europe for manufacturing of biopharmaceuticals (e.g., Actilyse) and Boehringer Ingelheim Austria is the center of excellence for biopharmaceuticals derived from microorganisms (e.g., Interferons).

Principal products/instrumentation: VTA170 video image analyzer; PVI-73 video marker, Pointmaker. Main products/instrumentation under R&D: Telemedicine system for pathology, preclinical.

558 BOEHRINGER INGELHEIM GMBH, DEPARTMENT INDUSTRIAL BIOPHARMACEUTICALS Add: Bingerstr. 173 Ingelheim/Rhein D-55216 Germany Tel: (49) 6132-77-98275 Fax: (49) 6132-77-98287

Sealed and granted patents: Pharmaceutical composition for immunomodulation based on peptides and adjuvants. 7,105,162, U.S.; Viral polymerase inhibitors. 6,794,404, U.S.; Fluorescence polarization assay. 6,794,158, U.S. Hepatitis C inhibitor peptides, 6,767,991, U.S.; Macrocyclic peptides active against the hepatitis C virus, 6,608,027, U.S.; other patents are pending.

E-mail: [email protected]. com Web site: www.boehringer-ingelheim.com President: Prof. Rolf Werner, Department Head R&D expertise: Research, development and production of biopharmaceuticals, mammalian cell culture and microbial technology. Technological expertise: C/TC, F, GT, H/CF, RD, T, E Principal products/instrumentation: Tipranavir (Aptiva’s), for treatment of HIV, 2005; rtPA Tissue plasminogen activator, ACTILYSE; rIFN-gamma (gamma-Interferon) IMUKLN; rIFN-beta (beta-Interferon), BETAFERON; rTNF-alpha (Tumor necrosis factor alpha), BEROMUN; Spiriva HandiHaler (Tiotropium Bromide), for the long-term, oncedaily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, 2004; Apitvus co-administered with 200mg of ritonavir, is indicated for combination antiretroviral treatment of HIV-1 infected adult patients, 2005.

559 BOEKEL SCIENTIFIC Add: 855 Pennsylvania Blvd. Feasterville, PA 19053 Tel: (215) 396-8200 Fax: (215) 396-8264 E-mail: [email protected] Web site: www.boekelsci.com President: Alfred W. Bush Research director: Mike Revesz R&D expertise: Development and manufacture of laboratory biomedical equipment for research and clinical lab, specializing in molecular biology apparatus. Technological expertise: BME, H/CF Principal products/instrumentation: Benchtop cooling incubators, a wide variety of hybridization ovens, slow speed rockers and gyratory rotators, dry bath incubators, shaking incubators, Slide Moat in-situ hybridization incubator.

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560 BORON BIOLOGICALS, INC. Add: 1437 US Hwy 52 North, Suite 195 Mt. Airy, NC 27030 Tel: (540) 728-0595 Fax: (540) 728-0315 Web site: www.boronbiologicals.com

products, diagnostics, reagents, Accurate External Run Controls, Quality Control Panels, AccuChart QC software. Main products/instrumentation under R&D: Anti-HIV drugs, preclinical; natural compounds. Subsidiary bodies: Three separate patents filed for three families of natural compounds that inhibit HIV from replicating.

President/CEO: Bernard F. Spielvogel, Ph.D. R&D expertise: Research, development and manufacture of boron biochemicals for commercial applications in the life sciences (chiefly pharmaceuticals) and other fields, DNA reagents and diagnostics.

562 BOSTON BIOSYSTEMS, INC. Add: 75A Wiggins Ave. Bedford, MA 01730 Tel: (781) 271-1580

R&D collaboration: Guerbet S.A./MacroNex.

Fax: (781) 271-1588

Technological expertise: Q, SY, D-D, AB, COC

E-mail: [email protected]

Principal products/instrumentation: Pharmaceuticals, diagnostics, agriculture, specialty chemicals, reagents, BNCT compounds for cancer; boron analogues of amino acids and peptides, boronated nucleoside triphosphates.

President: Jack Johnasen

Main products/instrumentation under R&D: Boronated antisense strands nucleosides; boron neutron capture therapy cancer radiation products.

Web site: www.avecialsm.com Research director: Nanda Sinha Ph.D. Subsidiary of Avecia, Inc. R&D expertise: GMP contract development and manufacture of oligonucleotides. Technological expertise: AB, P/S, SY, C/TC Principal products/instrumentation: Oligonucleotides, nucleic acid analogs, nucleic acid chemistry, large-scale DNA synthesis.

561 BOSTON BIOMEDICA, INC. 563 BOSTON EXPRESS LABORATORY Add: 375 West St. West Bridgewater, MA 02379 Tel: (508) 580-1900

Add: 1372 Hancock St., Suite 303 Quincy, MA 02169

Fax: (508) 580-2202

Tel: (617) 770-9336

Web site: www.bbii.com

Fax: (617) 770-9336

President/CEO: Richard T. Schumacher

E-mail: [email protected]

Research director: Mark Manak, Ph.D.

President: Amy Ho

R&D expertise: Development and manufacture of quality control products for infectious disease testing.

Research director: Amy Ho

Principal products/instrumentation: Contract manufacturing products, contract research

Joint ventures: Cotter & Chan BioScience Inc.

R&D expertise: Development and production of polyclonal chicken antibodies.

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R&D collaboration: Dana-Farber Cancer Institute. Key sales market contracts: Capralogics Inc.

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565 BOVA-CAN LABS

Key license and trade contracts: DanaFarber Cancer Institute.

Add: C/o Sask. Research Council 15 Innovation Blvd. Saskatoon, Saskatchewan S7N 2X8 Canada

Technological expertise: I, B, E, PA, P, SM, Y

Tel: (306) 933-7700

Principal products/instrumentation: Bioremediation, biosensors, natural products, pesticides, pharmaceuticals, reagents, chicken antibody for immunoassay, proteins, peptides, tumor markers and environmental pollutants.

Fax: (306) 933-5505

Main products/instrumentation under R&D: Chicken anti-receptor proteins, preclinical.

R&D expertise: Research of genetic diagnosis for animals, and applied products manufacture.

E-mail: [email protected] President: G.S. Cherry Research director: Y. Plante Subsidiary of Bova-Can Inc.

R&D collaboration: Agriculture Canada, University of Saskatchewan, University of Guelph. 564 BOSTON LIFE SCIENCES, INC.

Key license and trade contracts: USDA Technological expertise: Q, T, G, RD, GA

Add: 137 Newbury St., Floor 8 Boston, MA 02116-2912 Tel: (617) 890-8263 Fax: (617) 890-8267 E-mail: [email protected] President/CEO: S. David Hilison Research director: Marc E. Lanser, M.D. R&D expertise: Research of drug design, drug delivery and recombinant DNA; relative novel products development and manufacture. Key license and trade contracts: Zeneca Pharmaceuticals. Technological expertise: Q, RD, DD Main products/instrumentation under R&D: Products relating to cancer, autoimmune and Parkinson’s disease, all preclinical; Therafectin, for treatment of NDA to treat Rheumatoid Arthritis. Sealed and granted patents: Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis. 6,465,431, U.S.

Principal products/instrumentation: Bovine parentage verification PCR tests for BLAD, Kappa-casein, beta-lactoglobulin karyotyping, purity tests for elk and red deer. Main products/instrumentation under R&D: Diagnostic test for paratuberculosis, preclinical; DNA microsatellites for gene mapping, Phase II; Tests for QTL’s in dairy cattle.

566 BRAIN AG Add: Darmstadter Strasse 34 Zwingenberg 64673 Germany Tel: (49) 06-2519-3310 Fax: (49) 06-2519-33111 E-mail: [email protected] Web site: www.brain-biotech.de CEO: Dr. Holger Zinke Research director: Dr. Juergen Eck R&D expertise: R&D of molecular biology, biodiversity and screening, related novel products manufacture.

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R&D collaboration: Madaus AG, Cologne, Germany. Technological expertise: E, F, C/TC, DD, GA, HTDS, DG, P/S, RD, R Main products/instrumentation under R&D: Recombinant mistletoe lectin, Phase II/III.

pumps, Accu-jet pipette controller; Lightwave, spectro-photometer.

569 BRANSON ULTRASONICS CORPORATION Add: 41 Eagle Rd. Danbury, CT 06813

567 BRAND-NU LABORATORIES, INC.

Tel: (203) 796-0400 Fax: (203) 796-9838

Add: 377 Research Parkway Meriden, CT 06450 Tel: (203) 235-7989 Fax: (203) 235-7163 E-mail: [email protected] Web site: www.brandnu.com President: John Gorman R&D expertise: Manufacture and marketing of reagent and fine chemicals. Technological expertise: CC, COC, P/S, SY Principal products/instrumentation: Fine chemicals, contract manufacturing products, custom buffers and reagents, BioSolutions.

568 BRANDTECH SCIENTIFIC, INC.

E-mail: [email protected] Web site: www.Branson-PlasticsJoin.com President: Anthony Pajk Research director: Donald Lovett R&D expertise: Development and manufacture of plastics joining equipment, precision cleaning equipment and ultrasonic cell disruption equipment. Technological expertise: P/S, C/TC, BME, SI Principal products/instrumentation: Ultrasonic cleaning unit; Cell disruption unit.

570 BRENDAN SCIENTIFIC Add: 18530 Mack Ave, Ste. 350 Grosse Pointe, MI 48236

Add: 25 Middlesex Turnpike Essex, CT 06426-1479

Tel: (248) 395-1700

Tel: (860) 767-2562/(888) 522-2726

E-mail: [email protected]

Fax: (860) 767-2563

Web site: www.brendan.com

E-mail: [email protected]

President: John R. Dunn, Ph.D.

Web site: www.brandtech.com

R&D expertise: Research, Design and manufacture of workflow and analysis software for ELISA’s, RIA’s and all other immunoassay.

President/CEO: S. Brinkmann R&D expertise: Development of bio/pharma/ clinical research instruments, related novel products manufacture. Principal products/instrumentation: Dispensotte bottletop dispenser, Dispensette; Transferpette single and multichannel pipettes, Transferrpette; Vacuubrand oil-free vacuum

Fax: (248) 395-1705

Technological expertise: BI, BA, CH/S, BME Principal products/instrumentation: Clinical tests, contract manufacturing products, contract research/clinical trials products, instrumentation, pharmaceuticals, reagents, vaccines, veterinary products, statLIA workflow and

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analysis, StatLIA; software for immunoassays: including interfacing/networking, data reduction, data management, statistical analysis.

571 BRESAGEN LIMITED Add: 38 Winwood St. The Barton, SA 5031 Australia Tel: (61) 8-234-2660 Fax: (61) 8-234-6268 E-mail: [email protected] Web site: www.bresagen.com President/CEO: John Smeaton R&D expertise: Drug discovery research, biopharmaceutical development, transgenesis basic research. Joint ventures: Commercialization of protein pharmaceutical products and the development of cloning; cell therapy technology. Technological expertise: BA, C/TC, DD, DDI Principal products/instrumentation: Equine Somatotropin, Equigen. Main products/instrumentation under R&D: GM-CSF Antagonist-E21R, Phase III/IV; Canine Somatotropin-CST; Interlukin-5-IL5 and Human Growth Hormone-hGH, preclinical; Cell Therapy “drug”, IL-S antagonist, E13R, hGH, cell therapy — Parkinson’s disease, myleoid leukemia, growth deficiency, solid tumors; protein drugs and stem cells. START Grant-Ausindustry-Two; SPIRT Grant. Sealed and granted patents: Cell Therapy, GM-CSF Antagonist.

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Fax: (703) 243-9746 President: James T. Ogle R&D expertise: Research and development of products for biotechnology, diagnostic, pharmaceutical, and device products requiring U.S./ex-U.S. approvals. Joint ventures: CMIC Co. Ltd. of Tokyo, Japan (Japanese CRO); Rheumatology Research International (Consortium of Investigators). Technological expertise: CH/S, DD, All phases of the regulatory approval process, including clinical trials management and multinational clinical studies, strategic regulatory planning, international product registration, quality systems development, biometrics and pharmacoeconomics. Main products/instrumentation under R&D: Various instruments/equipment for biotechnology, diagnostic and pharmaceutical research/ manufacture. Subsidiary bodies: Arlington, VA, USA; San Diego, CA, USA; So. San Francisco, CA, USA; Chapel Hill, NC, USA; Rockville, MD, USA; East Sussex, UK; Surrey, UK; Mechelen, Belgium; Neuilly/Seine, France; Tokyo, Japan.

573 BRIDGEHEAD TECHNOLOGIES, LTD. Add: 37-39 Burton St. Melton Mowbray Leics LE13 1AF UK Tel: (44) 16-6450-0796 Fax: (44) 16-6441-1991 E-mail: [email protected] Web site: www.bridgehead.uk.com

572 BRI (BIOMETRIC RESEARCH INSTITUTE, INC.) Add: 1300 North 17th St. Suite 300 Arlington, VA 22209-3801 Tel: (703) 276-0400

President: F. David Alcraft, B. Pharm., Fiona J. Paton, Ph.D. R&D expertise: International consultancy: active in the pharmaceutical, biotechnology, diagnostic and medical equipment sectors. Company spent 20 years in the pharmaceutical industry with Glaxo, Astra and Fisons in

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commercial roles living in the UK, Sweden and Switzerland.

Tel: (410) 820-8800

Technological expertise: BTC, CB, BME

Web site: www.brinstrument.com

Principal products/instrumentation: Biotechnology new drug products, including DNA vaccines, gene targeting products, new drug discovery and development, recombinant proteins, recombinant vaccines.

President: Roger Roark, Sr.

Fax: (410) 820-8141

Research director: Paul Van Trieste R&D expertise: Research, development, manufacturing and sales of lab professional equipment. Technological expertise: P/S

574 BRINKMANN INSTRUMENTS, INC. Add: One Cantiague Rd. P.O. Box 1019 Westbury, NY 11590-0207 Tel: (516) 334-7500 Fax: (516) 334-7506 E-Mail: [email protected] Web site: www.brinkman.com

Principal products/instrumentation: 8300 High Purity Solvent Recycling System; 8400 High Purity Solvent Recycling System; 8600 High Purity Solvent Recycling System; Pureform 2000 Formalin Recycling System, new type high purity solvent recycling system. 576 BROOKHAVEN INSTRUMENTS CORP.

President/CEO: Martin N. Farb R&D expertise: Development of laboratory instruments/apparatus and imported in the U.S. and Canada.

Add: 750 Blue Point Rd. Holtsville, NY 11742

Technological expertise: BME, SI

E-mail: [email protected]

Principal products/instrumentation: Agriculture, biologicals, biomaterials, bioremediation, biosensors, contract research products, cosmetics, detergents, diagnostics, natural products, organ transplants/culture, pesticides, plastics, process validation, reagents, vaccines, Eppendorf pipettes liquid handling products, metrohm titration systems, Lauda circulating baths and chillers, Buchi rotary evaporators and Kjeldahl systems, Brinkmann polytron homogenizers, Heidolph/Brinkmann Stirrers, Retsch/Brinkmann grinders and Sievers, Eco chemie electrochemical instruments, Buchi melting point apparatus and fat extractor; Kinematica polytron PT 10-35 GT homogenizer, 2007.

Web site: www.bic.com

575 B/R INSTRUMENT CORP. Add: 9119 Centreville Rd. Easton, MD 21601

Tel: (516) 758-3200 Fax: (516) 758-3255

President: Dr. Walther Tschamuter Research director: William Bemt R&D expertise: Development and manufacture of particle size and zeta potential analyzers and light scattering equipment. Technological expertise: BME Principal products/instrumentation: BI200SM BI-9000AT, BI-XPC, BI-OCP, BI-90, BI-90Pfus, Bl-ZetaPlus, BI-Zeta Pals, BI-Foqels. Main products/instrumentation under R&D: Particle size and zeta potential analyzers, light scattering equipment. 577 BRT-BURLESON RESEARCH TECHNOLOGIES, INC. Add: 5706 Chapel Hill Rd. Raleigh, NC 27607

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Tel: (919) 851-4499

Fax: (31) 20-613-7596

Fax: (919) 851-4441

E-mail: [email protected]

E-mail: [email protected]

Web site: www.brunschwig.nl

President: Gary R. Burleson, Ph.D.

President/CEO: H.V. Brunschwig

Research director: Gary R. Burleson, Ph.D.

R&D expertise: Research and development of compounds for biotechnological and analytical purposes.

R&D expertise: Contract research and development of laboratory professional devices in immunology, virology, immunotoxicology, animal models and pharmacogenomics; related novel products manufacture. Technological expertise: C/TC, CH/S, G, PA, HTDS, H/CF, PG, R, COC Principal products/instrumentation: Biologicals, biosensors, contract research products, diagnostics, natural products, nutraceuticals, pesticides, vaccines.

Technological expertise: SMC, NAC, AMS Principal products/instrumentation: Biologicals, diagnostics, agriculture, pesticides, general reagents, media for microbiology and biotechnology; reagents for biochemistry. Subsidiary bodies: Storage and logistic services on behalf of third parties.

580 BSG, INC. 578 BRT LABORATORIES, INC.

Add: 48 Ravona St. Clifton, NJ 07012 Tel: (973) 815-0524

Add: 400 W. Franklin St. Baltimore, MD 21201 Tel: (410) 225-9595 Fax: (410) 383-0938

Fax: (973) 779-2467 President: Bruce Goldberg Research director: Bruce Goldberg

Web site: www.brtlabs.com

R&D expertise: Research of syringe filters — separation devices, novel products development.

President: Caroline Shepherd, M.Sc.

Technological expertise: P/S

Research director: Terry Houtz

Principal products/instrumentation: Biopharmaceuticals, reagents, syringe and Mkrofuge filters, ultrafilters, syringes, agarose, DNA purification.

R&D expertise: Genetic testing development therapeutic technologies research and relative applied products manufacture. Technological expertise: BI, CH/S, GA, RD Principal products/instrumentation: Paternity testing; forensic analysis diagnostic testing; apheresis technology; cell collection.

579 BRUNSCHWIG CHEMIE B.V.

Main products/instrumentation under R&D: Syringe filters separation devices.

581 BSI CORPORATION Add: 9924 West 74 St. Eden Prairie, MN 55344

Add: Hexaanweg 2 Building 2152 1041 AX Amsterdam Netherlands

Tel: (612) 829-2701

Tel: (31) 20-611-3133

President/CEO: Dale R. Olseth

Fax: (612) 829-2743

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Research director: Patrick E. Guire, Ph.D.

583 BTG INTERNATIONAL, INC.

R&D expertise: Development of surface chemistry technologies for biomedical, diagnostics, and high-value industrial applications; relative products manufacture.

Add: 2200 Renaissance Blvd. Gulph Mills, RA 19406

Key license and trade contracts: 41 in place with 27 proprietary clients.

Fax: (610) 278-1605

Technological expertise: CB, C/TC, PA, TE, DD, P/S, SMC, SY Principal products/instrumentation: Biologicals, biomaterials, specialty chemicals, contract research products, diagnostics, reagents photoLink surface modification and immobilization reagents, StabilCoat  immunoassay stabilizer, StabilZyme HRP conjugate stabilizer, StabilZyme AP conjugate stabilizer, StabilZyme  Select conjugate stabilizer. Main products/instrumentation under R&D: Implantable medical devices, diagnostics, biosensors, chromatography, and tissue culture.

582 BST SCIENTIFIC PRIVATE LIMITED Add: 10 Anson Rd., #03-09 International Plaza Singapore 079903 Singapore Tel: (65) 6777-2856 Fax: (65) 6777-2372 E-Mail: [email protected] Web site: www.bst-asia.com President: Francis Yap R&D expertise: Specializes in the sales and marketing of life sciences related products and services in the Southeast Asia region. Technological expertise: COC, PA, RD Key sales market contracts; Invitrogen Corp., Operon Technologies Inc., Biol Inc., MBI Fermentas, Amresco Inc., Maxim Biotech Inc., Scientific Specialties Inc. Principal products/instrumentation: Life sciences related products.

Tel: (610) 278-1660 E-mail: [email protected] Web site: www.btgplc.com President: Richard D. Gill, Ph.D. R&D expertise: Services to worldwide patent technology transfer of pharmaceutical/biotechnology novel inventions from companies, universities, non-profit research institutes to third parties. Key sales market contracts: NY Blood Center, Pre-S peptides for Hepatitis B and vaccine adjuvants; DuPont Pharmaceutical Company; Biogen and Warner Lambert — pharmaceutical technologies and compounds; Eli Lilly and American Cyanamid — agriculture and animal health technologies; Johnson & Johnson — medical imaging technologies. Key license and trade contracts: Factor EX licensed to Genetic Therapy, Genetics Institute; Gene Medicine; Trans-karyotic Therapies; Analgesic Combo, to Forest Labs; Cervidil to Pharmasciences/Forest Labs; Antifungals to Race Pharma. Technological expertise: PA, RD, AF, AB, CB, DD, GT, GA Principal products/instrumentation: Biologicals, nutraceuticals, pesticides, pharmaceuticals, vaccines, tomudex, Zinecard; Benefix, Cervidil Forest; Newcastle disease vaccine; Respiratory vaccine; Pasteurella vaccine. Main products/instrumentation under R&D: CB7630, preclinical; ZD 9331, Phase II; Campath 1H, Phase III; Miconazole pessary, Phase III/IV; Antimicrobial pessary, Phase III; Morphine rectal device, filed (UK); Pulsincap, Phase 1; Pharmaceutical polysaccharides, research/volunteer studies; Oxycodone/ibuprofen, Phase III/IV, Coccidiosis vaccine; Allergy

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vaccine (veterinary), preclinical; Factor IV (gene therapy), preclinical; SDZ-EAA-494, Phase III; De-feriprone, Phase III/IV; Iron chelators, research; Wound healing; preclinical; Recombinant protein production, preclinical; Immunological control of fat, research; VML-252, Phase II; Humanized anti-CD3 monoclonal antibody, Phase III/IV, HSV vector, research; Triiodothyronine (T3), preclinical. Subsidiary bodies: BTG plc, 10 Fleet Place, Limeburner Lane, London, EC4M 7SB, UK. Tel: (44) 0 20-7575- 0000, Fax: (44) 0 207575-0010 Sealed and granted patents: Over 8000 patents; increasing the trehalose content of organisms by transforming them with combinations of the structural genes for trehalose synthase, 6,323,001, U.S.

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spherical silica; IMPAQ augular silica; Kromasil chiral phases; Chirobiotic V; Chirobiotic T; Cyclobond I 2000™ (Kromasil to Eka Chemical, Chi-robiotic V, T, Cyclobond, TM of Astec). Main products/instrumentation under R&D: Bonded silica phases for preparatory/process separations of peptides and chiral drugs, liquid chromatographic separations media and columns. Sealed and granted patents: Silanol enriched surfaces (silica), sterically protected bondings for silica (chromatographic silica).

585 B/T SCI TECH Add: 6046 Cornerstone Ct. W. Suite 216 San Diego, CA 92121 Tel: (619) 587-0809

584 BTR-SEPARATIONS Add: Concord Plaza, Quillen Bldg. 3521 Silverside Rd. Wilmington, DE 19810 Tel: (800) 766-6141 Fax: (302) 695-5026 Web site: www.btrseparations.com President: Lanny Weaver Research director: William Johnson, Ph.D. Subsidiary of DCV INC. R&D expertise: Research, development and manufacture of liquid chromatographic separations media and columns for the pharmaceutical and biotechnology markets. Key sales market contracts: Advanced Separation Technologies, Whippany, NJ.

Fax: (619) 587-8034 E-mail: [email protected] Web site: www.virtualad.com/BTScitech R&D expertise: Development manufacture or allotment of specific products for molecular biology and biotechnology. Technological expertise: RD, GA, C/TC, CH/S Principal products/instrumentation: Speedlight gel documentation system of Lightools Research, Inc.; anaerobic tissue processor (cell/tissue homogenizer) of Professional Diagnostics, Inc.; bio 101, Sorenson Plastics, Shelton scientific centrifuges, Kompspin rotors, Singer Instruments, micromanipulators, Kendrick Labs-QGel, Fermentors, purification devices.

Key license and trade contracts: Agilent Technologies Inc. Technological expertise: CC, PIS, P/S, BA Principal products/instrumentation: Biologicals, natural products, food processing products, zorbax spherical silica; Zorbax LP

586 BUCK SCIENTIFIC, INC. Add: 58 Fort Point St. E. Norwalk, CT 06855 Tel: (203) 853-9444

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Fax: (203) 853-0569

Fax: (631) 249-6066

E-mail: [email protected]

E-mail: [email protected]

Web site: www.bucksci.com

Web site: www.bulbtronics.com

President: Roy Mirchandani

President/CEO: Bruce R. Thaw

Research director: Ed Nadeau R&D expertise: Development and manufacture of analytical instrumentation.

R&D expertise: Development and supply of replacement specialty bulbs for scientific and medical equipment and instrumentation.

Technological expertise: BME, AMS

Technological expertise: BME

Key sales market contracts: Cecil UK, Milestone srl

Principal products/instrumentation: Bioremediation, biosensors, contract research products, cosmetics, detergents, food process, organ transplants/culture, pesticides, toxic waste processing products, replacement specialty light bulbs: deuterium, noHow cathode, UV, IR.

Principal products/instrumentation: Cosmetics, detergents, minerals, pesticides, biopharmaceuticals, 210 VGP/220 Graphite Furnace Atomic Absorption Spectrophotometer, 910 Gas Chromatograph, QS4000 Mercury Analyzer, M500 Infrared Spectrophotometer.

587 BUEHLMANN LABORATORIES AG

589 BURKERT USA Add: 2602 McGaw Ave. Irvine, CA 92614 Tel: (949) 223-3100

Add: Baselstr. 55 Schoenenbuch CH-4124 Switzerland

Fax: (949) 223-3198

Tel: (41) 61-487-1212

President: Hal Reisiger

Fax: (41) 61-487-1234

Subsidiary of Burkert Contromatic

E-mail: [email protected]

R&D expertise: Research and manufacture of general-purpose valves, process valves, sensors, transmitters and controllers.

CEO: Dr. Roland P. Buehlmann R&D expertise: Development and manufacture of medical and research immunoassay kits. Technological expertise: RD, R/S, H/CF, C/TC, SY Principal products/instrumentation: Biologicals, diagnostics, clinical tests, veterinary products, reagents. Main products/instrumentation under R&D: Medical and research immunoassay kits.

588 BULBTRONICS, INC.

Web site: www.burkert-usa.com

Technological expertise: P/S, PMC, DD, PB Main products/instrumentation under R&D: biosensors, cosmetics, detergents, generalpurpose valves, process valves, sensors, transmitters, controllers.

590 BV SPHAERO Q Add: P.O. Box 32005 Leiden 2303 DA Netherlands Tel: (31) 71-522-7338

Add: 45 Banfi Plaza Farmmgdale, NT 11735

Fax: (31) 71-521-0636

Tel: (631) 249-2272

E-mail: [email protected]

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Web site: www.sphaero-q.demon.nl President: B. Jacob R&D expertise: PCR related products for molecular biology laboratories. Principal products/instrumentation: Biologicals, diagnostics, PCR related product.

591 BY-PROD CORPORATION

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Subsidiary bodies: Biosensors, diagnostics tule Lake, CA; Birmingham, UK.

593 CADMOS Add: 35 Avenue Des Princes Brabancons Bruxelles 1170 Belgium Tel: (32) 2-662-2616 Fax: (32) 2-675-8732

Add: St. Louis, MO 63166

E-mail: [email protected]

Tel: (314) 534-3122

CEO: Dr. Rodolphe de Borchgrave

Fax: (314) 534-4422

R&D expertise: Management consulting and technology management of drug market.

E-mail: [email protected] President/CEO: Rick Schiff R&D expertise: Raw material development, manufacture and marketing of fetal bovine serum and various animal serums, glands, and tissues. Technological expertise: C/CT Main products/instrumentation under R&D: Fetal bovine serum; various animal serums; glands and tissues.

Joint ventures: Alliance Consulting, Arcadia International. Principal products/instrumentation: Drug market and technology analysis, biomaterials, specialty chemicals, detergents, food processing, pesticides.

594 CADUS PHARMACEUTICAL CORP. Add: 777 Old Saw Mill River Rd. Tarrytown, NY 10591-6705

592 CABTECH, INC. Add: Potomac, MD 20854 Tel: (301) 299-6380 Fax: (301) 299-1391 E-mail: [email protected] President: Muzaffar Iqbal, Ph.D. R&D expertise: Development and manufacture of molecular reagents and instrumentation for diagnosis of human infectious disease. Key license and trade contracts: University of Maryland. Technological expertise: PA, RD, Q Main products/instrumentation under R&D: Molecular reagents.

Tel: (914) 467-6200 Fax: (914) 345-3565 E-mail: [email protected] Web site: www.cadus.com President/CEO: Charles Woler, M.D., Ph.D. Research director: David R. Webb, Ph.D. R&D expertise: Research and development of pharmaceutical proprietary technologies that exploit the similarities between the yeast and human genomes to elucidate gene function and cell signaling pathways, related products manufacture. R&D collaboration: Trega Biosciences, SmithKline Beecham, Bristol-Myers Squibb, Solvay Duphar B.V., Axiom Biotechnologies, M.I.T., Genome Therapeutics.

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Key license and trade contracts: Duke University, M.I.T., and National Jewish Center for Immunology and Respiratory Medicine. Technological expertise: RD, R, C/TC, CH/S, SY, Q, COC, HTDS, SMC, D-D

Subsidiary of CN Biosciences R&D expertise: Development and manufacture of assay kits, antibodies and biochemical and biological reagents. Technological expertise: PA, CB, C/TC

Main products/instrumentation under R&D: Drugs for inflammation, immunological disease, cancer and selected cardiovascular diseases.

Principal products/instrumentation: Biologicals, detergents, reagents, and 4,000 bioreagents for study of signal transduction, apoptosis, glycobiology, and neuroscience.

Sealed and granted patents: Broad patents in yeast technology for coupling of mammalian G protein-coupled receptors.

597 CALBIOCHEM-NOVABIOCHEM AG

595 CAFRAMO, LTD.

Add: Weidenmattweg 4 Laufelfingen CH4448 Switzerland Tel: (41) 62-285-2525

Add: RR#2 Wiarton, Ontario NOH 2T0 Canada Tel: (519) 534-1080 Fax: (519) 543-1088 E-mail: [email protected] Web site: www.caframo.com President: T. Solecki R&D expertise: Development and manufacture of laboratory professional products. Principal products/instrumentation: Cosmetics, nutraceuticals, pharmaceuticals overhead electrical stirrers; compact Digital™ precise stirrer.

596 CALBIOCHEM Add: 10394 Pacific Center Court San Diego, CA 92121 Tel: (619) 450-9600 Fax: (619) 453-3552

Fax: (41) 62-285-2520 E-mail: [email protected] Web site: www.nova.ch President: Andreas Mueller Research director: Dr. Barbara Dorene Subsidiary of CN Biosciences R&D expertise: Development and production of amino acid derivatives for peptide synthesis, resins and linkers for combinatorial chemistry, custom peptide synthesis. Technological expertise: COC, PIS, SY Principal products/instrumentation: Biologicals, reagents, 2,200 products for peptide synthesis, combinatorial chemistry and pharmaceutical raw material production.

598 CALBIOMARINE TECHNOLOGIES, INC.

E-mail: [email protected]

Add: 6351 Corte del Abeto Ste A-101 Carlsbad, CA 92008

Web site: www.calbiochem.com

Tel: (760) 431-2214

President: James Stewart

Fax: (760) 431-5925

Research director: Dr. John Snow

E-mail: [email protected]

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Web site: www.calbiomarine.com

Technological expertise: Q, AB, RD, C/TC

President/CEO: Dominick Mendola

Main products/instrumentation under R&D: Agriculture products, flaw Savr tomato; BXN cotton, laurate canola and stearate canola sucrose phosphate synthase, specialty oils in plant seeds.

Research director: Barbara favor, Ph.D.J.D. R&D expertise: Marine natural products — drug development, bioprocessing research. R&D collaboration: National Cancer Institute, National Science Foundation, large-scale production of marine invertebrate natural products. Key license and trade contracts: UCSD/SIO Production of Bryostatins from Microbial Sources 6/99. Technological expertise: B, C, F, M, S Principal products/instrumentation: Pharmaceuticals, specialty chemicals, marine natural products. Main products/instrumentation under R&D: Biological systems for production of marine invertebrate and microbial natural products. Sealed and granted patents: Bioprocesses Marine Drug Compounds.

Sealed and granted patents: Sucrose phosphate synthase (SPS), its process for preparation of cDNA, and utilization of cDNA to modify the expression of SPS in plant cells. RE38, 446, U.S.; Nucleic acid sequences to proteins involved in isoprenoid synthesis. 7,067,647, U.S.; Acyl CoA: Cholesterol acyltransferase related nucleic acid sequences. 6,444,876, U.S.; Methods for producing carotenoid compounds, and specialty oils in plant seeds. 6,429,356, U.S.; Plastid transformation of Brassica. 6,891,086, U.S.; Nucleic acid sequences encoding betaketoacyl-ACP syntheses and uses thereof. 6,706,950, U.S.; Engineering B-ketoacyl ACP synthase for novel substrate specificity. 6,770,465, U.S.; others are pending.

600 CAL-GLASS FOR RESEARCH, INC. 599 CALGENE, INC. Add: 1920 Fifth St. Davis, CA 95616

Add: 3012 Enterprise Ave, Costa Mesa, CA 92626

Tel: (530) 753-6313

Tel: (714) 546-7250

Fax: (530) 753-1510

Fax: (714) 755-7800

Web site: www.calgene.com

E-mail: [email protected]

President: Roderick N. Stacey

Web site: www.cal-glass.com

Research director: Vic Knauf, Ph.D.

President/CEO: Robert J. Cheadey

R&D expertise: Research, development and production of genetically engineered plants and novel plant products for seed, food, and oleo chemical industries.

Research director: James R. Cheadey

Joint ventures: Quadrant Holdings, Cambridge Ltd., Kirin Brewery. R&D collaboration: Procter & Gamble, Rhone Pouienc Ag Co. Key license and trade contracts: Monsanto, Plant Genetics Systems, AgrEvo.

R&D expertise: Development and manufacture custom glass blowing both Pyrex and Quartz, Intelligent Automation Distillation, Solvent Fractionation, photo chemical recovery machine. Technological expertise: P/S, PMS Principal products/instrumentation: Toxic waste processing products, intelligent Automated Fractionator; Distillation Apparatus.

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Sealed and granted patents: Photo chemical effluent recovery technology.

601 CALGON CARBON CORPORATION Add: PO Box 717 Pittsburgh, PA 15230-0717 Tel: (412) 787-6754 Fax: (412) 787-4523 E-mail: [email protected] Web site: www.calgoncarbon.com CEO: Jim Cedema R&D expertise: Development and manufacture of advanced chromatographic, ion exchange simulated and moving bed separators. Technological expertise: CC, F, P/S, PIS Principal products/instrumentation: Biologicals, contract research products, natural products, nutraceuticals, pesticides, vaccines, ISEP Ion-Exchange Separator; CESP Chromatophic Separator; UV Oxidation Technology.

drug screening; Agilent Technologies, marketing and sale of lab chip products. Key license and trade contracts: Lockheed Martin (Oak Ridge National Lab), University of Pennsylvania, and Northeastern University. Technological expertise: BI, HTDS, G, SMC, RD, D-D, GT, P/S Principal LapChip.

products/instrumentation:

Main products/instrumentation under R&D: Lab-on-a-chip system, high throughput drug screening. Sealed and granted patents: Microfluidic Patents, more than 60 patent applications covering in-house microfluidic inventions; 59 issued patents, 16 allowed, 150 pending covering lab-on-a-chip technology.

603 CALTAG LABORATORIES Add: 1849 BayshoreBlvd #200 Burlingame, CA 94010 Tel: (650) 652-0468 Fax: (650) 652-9030

602 CALIPER TECHNOLOGIES CORP. Add: 605 Fairchild Drive Mountain View, CA 94043

E-mail: [email protected] Web site: www.caltag.com/caltag/ President/CEO: Helga Johnson

Tel: (650) 623-0700

Research director: Helga Johnson

Fax: (650) 623-0505

R&D expertise: Development and manufacture of immunological reagents for research and clinical diagnosis.

E-mail: [email protected] Web site: www.calipertech.com President/CEO: Daniel L. Kisner, M.D. Research director: Michael Knapp, Ph.D. R&D expertise: “Lab-On-A-Chip” systems development and manufacture. R&D collaboration: Hoffmann-La-Roche, high throughput drug screening; HP-development and sale of lab-on-a-chip products for research and analytical markets; Roche, Amgen, Lilly, Millenium Pharmaceuticals, high throughput

Technological expertise: P/S, H/CF, C/TC Principal products/instrumentation: Biologicals, diagnostics, monoclonal and polyclonal antibodies, immunological reagents.

604 CALWOOD NUTRITIONALS, INC. Add: 500 McCormick Drive, Suite J. Glen Burnie, MD 21061

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Tel: (410) 590-4890 or (800) 479-9942 Fax: (410) 590-2688 E-mail: [email protected] Web site: www.calwoodnutritionals.com President: Gary Calton Research director: John Hamman R&D expertise: Design and development of nutritional supplementation. Technological expertise: CB, DD, D-D Principal products/instrumentation: Nutraceuticals, biopharmaceuticals, amino acids. Main products/instrumentation under R&D: Other bioactive AA and derivatives, nutrilipid, nutrition, nutrient drug. Sealed and granted patents: Yes.

605 CALYDON, INC.

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Sealed and granted patents: Calydon files all patents globally. The following have been issued in the U.S. and are pending elsewhere: Tissue Specific and Tumor Growth Suppression by Adenovirus Comprising Prostate Specific Antigen. #5,871,726; Tissue Specific Enhancer Active in Prostate. #5,648,478; Tissue Specific Viral Vectors. #5,698.443; Tissue Specific Enhancer Active in Prostate. #5,830,686; Prostate Cancer Drug Screenings. #5,783,435; Prostate Cancer Screening using HKLK2 Enhancer. #6,051,417; Tissue Specific Enhancer Active in prostate. #6,057,299.

606 CALYPTE BIOMEDICAL CORP. Add: 1265 Harbor Bay Parkway Alameda, CA 94502 Tel: (510) 749-5100

Add: 1324 Chesapeake Terrace Sunnyvale, CA 94089 Tel: (408) 734-0733 Fax: (408) 734-2808 E-mail: [email protected] Web site: www.calydon.com President/CEO: Daniel R. Henderson, Ph.D. Research director: De-Chao Yu, Ph.D. R&D expertise: Development and manufacture of biopharmaceuticals for the treatment of cancer (prostate and other cancers).

Fax: (510) 814-8408 E-mail: [email protected] Web site: www.calypte.com President/CEO: Nancy E. Katz Research director: Toby D., Gottfried, Ph.D. R&D expertise: Research, development and manufacturer of urine-based diagnostic products and services for HIV, sexually transmitted diseases and other chronic illnesses.

Technological expertise: RD, BA, C/TC, D-D, GT, PMC, P/S

Key sales market contracts: Seradyn Inc., Otsuka Pharmaceutical Co., Ltd., Travenol (Israel).

Principal products/instrumentation: Anticancer pharmaceuticals.

Technological expertise: PA, RD, C/TC, CH/S, GA, P/S

Main products/instrumentation under R&D: Viral therapeutics to target prostate cancer (CN-706 and CV-787), clinical trials — Phase II/III; Tissue specific viruses that selectively infect and destroy cancer cells, R&D/preclinical, prostate cancer drug screening, tissue specific viral vectors.

Principal products/instrumentation: Calypte HIV-1 Urine EIA Diagnostic Kit, Cambridge Biotech HIV-1 Western Blot Kit, Cambridge Biotech. Main products/instrumentation under R&D: OTC HIV Urine Collection System, preclinical; Rapid HIV-1 Urine EIA, preclinical.

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Sealed and granted patents: Detection of HIV-1 antibodies in urine; detection of chlamydia antibodies in urine.

607 CALZYME LABORATORIES, INC.

R&D collaboration: University of Cambridge. Key sales market contracts: Epicentre Technologies, Bioventures Inc., Trevigen, CPG, Glen Research. Key license and trade contracts: Amersham International, Hoffmann-La-Roche.

Add: 3443 Miguelito Court San Luis Obispo, CA 93401

Technological expertise: PA, T, GT, RD, P/S, BI, SY, BA, AB, GA

Tel: (805) 541-5754

Principal products/instrumentation: Star Fish chromosome paints; Parr Buffer; Sequitherm Excel; Fast-Unk; Masteramp. Antibodies, chaperonin proteins, oligonucleotide synthesis products, DNA ladders, microcentrifuges, molecular biologicals.

Fax: (805) 541-8301 E-mail: [email protected] Web site: www.calzyme.com President: Muzaffar Iqbal, Ph.D. R&D expertise: Development and manufacture of protein and enzyme purification and scale-up, bioprocess engineering products. Technological expertise: F, E, AF, P/S, BA, COC, PA Principal products/instrumentation: HRP, ALP, CPK, biologicals, pharmaceuticals, diagnostics, agriculture, biomaterials, biosensors. Antibiotics, enzymes, single cell proteins. Subsidiary bodies: Tule Lake, CA; Birmingham, England, UK; Pakistan.

609 CAMBRIDGE ANTIBODY TECHNOLOGY PLC Add: The Science Park Melbourn, Cambs SG8 6JJ UK Tel: (44) 17-6326-3233 Fax: (44) 17-6326-3413 E-mail: [email protected] President: Prof. Peter B. Garland Research director: Kevin Johnson, Ph.D.

608 CAMBIO Add: 34 Newnham Rd. Cambridge CB3 9EY UK Tel: (44) 12-2336-6500 Fax: (44) 12-2335-0069 E-mail: [email protected] Web site: www.cambio.co.uk President/CEO: Dr. Peter Dean Research director: Dr. Peter Dean R&D expertise: Research of cell and tissue culture in molecular biology, technology transfer, molecular biologicals. Joint ventures: University of Cambridge.

R&D expertise: R&D of antibody engineering; Drug discovery, design and development. Joint ventures: Obesys, Progenitor, ICOS. R&D collaboration: Pharmacia P-L Biochemicals; Igen, Inc; Merck, Co.; Boehringer Mannheim; Knoll AG, Sumitomo; Mitsubishi; Genentech; Pfizer, Eli Lilly. Key license and trade contracts: Pharmacia P-L Biochemicals; Medical Research Council, Genentech, Pfizer, Eli Lilly, Telios Pharmaceuticals. Technological expertise: PA, HTDS, RD, GA, H/CF, BI, D-D Main products/instrumentation under R&D: Therapeutic human monoclonal antibodies,

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antibody gene repertoires, ribosome binding sequence.

Web site: www.isotope.com

Subsidiary bodies: Denzyme ApS.

R&D expertise: Research and development of stable isotope labeled compounds, cell growth media and biopharmaceuticals.

Sealed and granted patents: Antibody gene repertoires, phage display, ribosome display.

President: Joel C. Bradley

Technological expertise: RD, COC 610 CAMBRIDGE DISCOVERY CHEMICAL™ (FORMERLY CAMBRIDGE COMBINATORIAL) Add: The Merrifield Centre, Rosemary Lane Cambridge CB1 3LQ UK Tel: (44) 12-2372-2400

Principal products/instrumentation: Stable isotope labeled compounds: NMR solvents; specialty gases; amino acids; BioExpress Cell Growth Media; forensic standards, RNA/DNA products; buffers, metabolites; fatty acids; sugars; environmental contaminant standards, cell growth media, biopharmaceuticals.

Fax: (44) 12-2372-2401 E-mail: [email protected] Web site: www.cam-com.com CEO: Dr. Allan Marchington Research director: Dr. Dave Tapolczan R&D expertise: Drug discovery research and related products development for the pharmaceutical, agrochemical and biotechnology industries. R&D collaboration: Rohm & Haas (U.S.), Pfizer (UK/NS), Mitsubishi Chemical Corp., Solvay Duphar, Procter & Gamble, Fugisawa, Dainippon. Technological expertise: COC, D-D, SMC, SY, DDI Principal products/instrumentation: Contract research products, pesticides, pharmaceuticals, and services for accelerating drug discovery processes.

612 CAMBRIDGE MOLECULAR Add: Cambridge Techno Park New Market Road Cambridge CBS 8PB UK Tel: (44) 12-2350-8333 Fax: (44) 12-2350-6541 Web site: www.cmtech.co.uk Research director: Neil Butt R&D expertise: Research of nucleic acid extraction and purification technologies, related products production. Technological expertise: Q, GA, P/S, R Main products/instrumentation under R&D: Nucleic acid extraction and purification technologies, nucleic acid extractor, nucleic acid purificator.

613 CAMBRIDGE NEUROSCIENCE 611 CAMBRIDGE ISOTOPE LABORATORIES, INC.

Add: One Kendall Square Bldg. 700 Cambridge, MA 02139

Add: 50 Frontage Rd. Andover, MA 01810

Tel: (617) 225-0600

Tel: (978) 749-8000

Fax: (617) 225-2741

Fax: (978) 749-2768

Web site: www.cambneuro.com

E-mail: [email protected]

President/CEO: Elkan Gamzu, Ph.D.

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Research director: Robert N. McBurney, Ph.D.

Tel: (617) 441-0600

R&D expertise: Development and manufacture of novel therapeutics for neurodegenerative diseases.

Web site: www.camtech.com

Joint ventures: Boehringer-Ingelheim.

President: Redmond Aylward Subsidiary of Excel Technology

R&D collaboration: Boehringer-Ingelheim.

R&D expertise: Design, development and manufacture of Microplate instrumentation.

Key sales market contracts: BoehringerIngelheim.

Technological expertise: CH/S

Technological expertise: Q, BA, RD, P/S, GA, H/CF, C/TC, SY, D-D, SMC Main products/instrumentation under R&D: Cerestat, Phase III/IV for stroke; brain injury; CNS 5161, preclinical; Glial Growth Factor 2, preclinical; other novel therapeutics for neurodegenerative disease, preclinical.

614 CAMBRIDGE RESEARCH BIOCHEMICALS (CRB)

Principal products/instrumentation: PHD Cell Harvesters; 7,500 Series Microplate ELISA Readers; 7,600 Series Microplate Fluorometer; 7,700 Series Microplate Luminometers; 6,000 Series Optical Scanners.

616 CAMITRO CORPORATION Add: 4040 Campbell Ave. Menlo Park, CA 94025 Tel: (650) 614-7080

Add: P.O. Box 2, Belasis Ave. Billingham Cleveland T523 7YN UK

Fax: (650) 327-4639

Tel: (44) 0-16-4236-4407

Web site: www.camitro.com

Fax: (44) 0-16-4236-4451

President: Dr. Harold E. “Barry” Selick

E-mail: [email protected]

Research director: Dr. Kenneth Korzekwa

Web site: www.crb.gb.com President: E. Humphreys, A. White, David Woodhouse, Ph.D.

R&D expertise: Computational models for predicting ADME/TOX properties of new drug compounds.

Research director: David Woodhouse, Ph.D., A. White

Joint ventures: Pharmaceutical and biotechnology companies.

R&D expertise: Drug discovery research through production of custom peptides, antibodies and radio labeled peptides.

R&D collaboration: Pharmaceutical and biotechnology companies.

Technological expertise: PIS, PA, SY, CS Principal products/instrumentation: Chemicals, biopharmaceuticals, reagents, peptides, drug discovery route.

615 CAMBRIDGE TECHNOLOGY, INC. Add: 109 Smith Place Cambridge, MA 02138

E-mail: [email protected]

Technological expertise: SMC, RD, C/TC, CH/S, D-D, GA, HTDS, P/S Main products/instrumentation under R&D: Computational models for predicting drug metabolism, beta-evaluation; Computational models for predicting drug absorption, betaevaluation; Computational models for predicting blood-brain barrier penetration, beta-evaluation; computational models for predicting drug human intestinal absorption.

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617 CAMO ASA Add: NedreVoll GT.8 Oslo N-0158 Norway Tel: (47) 22-396-300 Fax: (47) 22-396-322 E-mail: [email protected] Web site: www.camo.no President: Bjom Skare Research director: Michael Begstrom R&D expertise: Development, manufacture and supply of data analysis and experimental design software, training, consultants. Key sales market contracts: Yokogawa, Foss Electric, Bran & Luebbe, UOP Guided Wave, Perstorp, Broker Optics. Technological expertise: CH/S, PMC

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R&D collaboration: Apoptogen, base 4, Allelrx, IBEX, INEX, MDS-Sciex, Merck. Technological expertise: PA, Q, T, GA, GT, RD Principal products/instrumentation: Diagnostics, human genome project. Main products/instrumentation under R&D: Genes identification for common disease, pathogenesis and functional genomics, genetic therapies.

619 CANADIAN VALUE-ADDED CEREALS CONSORTIUM, INC. Add: 101-111 Research Dr. Saskatoon, SK S7N 3R2 Canada

Principal products/instrumentation: Biosensors, contract research products, cosmetics, instrumentation, pharmaceuticals, plastics, Unscrambler; Guideline.

Tel: (306) 668-2652

Main products/instrumentation under R&D: Data analysis and experimental design software, preclinical.

Research director: Stephane Dupont, Ph.D.

618 CANADIAN GENETIC DISEASES NETWORK

Fax: (306) 975-1966 E-mail: [email protected]. sk.ca R&D expertise: Research and development of transgenics and recombinant DNA to developing commercially viable value-added cereal products.

E-mail: [email protected]

R&D collaboration: R&D and collaborative agreements for the Wheat Hybridization Project between DowElanco, AgrEvo, Novartis, Zeneca, Cargill, Pioneer Hi-Bred, Monsanto, DuPont, National Research Council-Plant Biotechnology Institute, Agriculture and AgriFood Canada-Cereal Research Centre and the CVACC.

Web site: www.cdgn.generes.ca

Technological expertise: Q, T, RD

President: Dr. Michael Hayden Research director: Dr. Michael Hayden

Principal products/instrumentation: Food processing product, natural products.

R&D expertise: Research of genes identification for common diseases, pathogenesis and functional genomics, genetic therapies and genetics and healthcare, products development.

Main products/instrumentation under R&D: Molecular technology for the control of gamete viability and the production of hybrid wheat varieties, recombinant DNA.

Add: 350-2125 East Mall Vancouver, British Columbia V6T 1Z4 Canada Tel: (604) 822-7886 Fax: (604) 822-7945

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620 CANCER THERAPEUTICS, INC. Add: 100 Covey Dr. Ste. lll Franklin TN 37064 Tel: (800) 279-2796 Fax: (615) 794-9110 E-mail: [email protected] Web site: www.cancer-therapeutics.com President/CEO: Robert K. Oldham, M.D. Research director: Dr. Walter Lewko R&D expertise: Cultivation research of Tumor Derived Activated Lymphocyte Cells (TDAC/ TIL) and autologous vaccines for the treatment of cancer, and related products development. Joint ventures: Dr. Lynn Spitler, Northern California Melanoma Clinic — cultivating of cell lines. R&D collaboration: Chiron Corp./IL-2. Technological expertise: C/TC

Key sales market contracts: Cheil Jedang, HealthCare Asia, Nabi, Octapharma, CSL Ltd. Technological expertise: F, PA, RD, P/S, CH/S, PIS Principal products/instrumentation: Biologicals, contract manufacturing products, antihepatitis-B Ab (Hepagam B) treat acute infection of hepatitis B, 2006. WinRho SDF. Main products/instrumentation under R&D: Leucotropin (recombinant GM-CSF), Phase III/IV; VZIG, Phase III/IV; Recombinant Human Growth Hormone, Phase I/II; AntiHepatitis B, Phase I/II, genetic recombinant biopharmaceuticals. Subsidiary bodies: FDA-licensed ISO9001 manufacturing facility in Winnipeg, available contract manufacturing services.

622 CANGENE CORPORATION

Principal products/instrumentation: Biological, vaccines, anticancer drug.

Add: 104 Chancellor Matheson Rd. Winnipeg, MB R3T 5Y3 Canada

Main products/instrumentation under R&D: Tumor derived activated lymphocyte cells for the treatment of cancer, autologous vaccines for the treatment of cancer, IL-2.

Tel: (204) 275-4310 Fax: (204) 275-7003 E-mail: [email protected] Web site: www.cangene.com President/CEO: Dr. John Langstaff

621 CANGENE CORPORATION Add: 3403 American Dr. Units 3 & 4 Mississauga, Ont. L4V 1T4 Canada Tel: (905) 673-0200 Fax: (905) 673-5123 E-mail: [email protected] Web site: www.cangene.com President/CEO: Dr. John Langstaff Research director: Wendy Johnson R&D expertise: Research of hyperimmunes, genetic recombinant biopharmaceuticals and contract manufacturing. R&D collaboration: Apotex Holdings Inc.

Research director: Wendy Johnson R&D expertise: Biopharmaceutical research, development and manufacturing; contract research. Technological expertise: PA, RD Principal products/instrumentation: Anti-D Immune Globulin, WinRho SDF, Biologicals, contract manufacturing products. Main products/instrumentation under R&D: Leucotropin, GM-CSF, for myeloid reconstitution following autologous peripheral blood stem cell transplantation, Phase III completed, 2008; GM-CSF (Granulyte Macrophage Colony Stimulating Factor), Phase III; hGH (Human Growth Hormone), preclinical, varicella

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zoster immune globulin (NDS field), hepatitis B immune globulin; HepaGam B® human hepatitis B immune globulin for prevention of hepatitis B virus (HBV) recurrence following liver transplant in hepatitis B surface antigen (HBsAg)-positive patients, 2007. Subsidiary bodies: Cangene Corp. — Biotech Div., 26 Henlow Bay, Winnipeg, MB R3Y 1GA, Tel: (204) 989-6850, Fax: (204) 9896879; Cangene Corp. — Plasma Centre, 818233 Kennedy St., Winnipeg, MB R3C 3J5, Tel: (204) 989-6635, Fax: (204) 942-4820; Cangene Corp., Units 3-4, 3404 American Dr. Mississauga, Ont. L4V 1T4, Tel: (905) 6730200, Fax: (905) 673-5123.

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U.S.; Methods of treating hyperproliferative disorders using retinoblastoma fusion proteins. 6,902,731, U.S.; Rat secreted embryonic alkaline phosphatase. 7,157,261, U.S.; Nucleic acid delivery, 7,094,583, U.S.; Aptamer-mediated regulation of gene expression. 6,949,379, U.S.; others are pending.

624 CANSERA INTERNATIONAL, INC. Add: 165A Bethridge Rd. Rexdale, ON M9W 1N4 Canada Tel: (416) 744-8996 Fax: (416) 744-8401 E-mail: [email protected]

623 CANJI, INC. Add: 3030 Science Park Rd. Suite 302 San Diego, CA 92121 Tel: (619) 597-0177 Fax: (619) 597-0237 President: Kenneth M. Cohen Research director: H. Michael Shepard, Ph.D. R&D expertise: Research, development and manufacture of therapeutics based on tumor suppressor genes. R&D collaboration: Schering-Plough Corp., p53 gene therapy; Amoco/Vysis, Inc., tumor suppresor gene diagnostics. Key license and trade contracts: University of California, University of Texas, California Pacific Medical Center. Technological expertise: Q, C/TC, GA, GT Principal products/instrumentation: Biologicals, vaccines, reagents, antibodies. Main products/instrumentation under R&D: Therapeutics based on tumor suppressor genes, anticancer pharmaceuticals, p53, preclinical; RB, preclinical; p53 gene therapy, tumor suppressor gene diagnostics. Sealed and granted patents: Recombinant adenoviral vector and method of use. 7,041,284,

Web site: www.wlc.com/cansera President: Jane Haffenden R&D expertise: Development and manufacture of animal sera and cell culture media products. Contract OEM sterile filtration. Technological expertise: C/TC Principal products/instrumentation: Biologicals, low endotoxin fetal bovine serum; antibody-free donor calf serum. Main products/instrumentation under R&D: Animal sera, cell culture media products, OEM sterile filtration technology.

625 CANTAB PHARMACEUTICALS PLC Add: 184 Cambridge Science Park Milton Road Cambridge, Cambridgeshire CB4 4GN UK Tel: (44) 22-3423-4413 Fax: (44) 22-3423-458 President/CEO: Dr. Paul Haycock Research director: Dr. Alan J. Munro R&D expertise: Discovery, design and development of biopharmaceuticals that use the selective properties of the human immune system.

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R&D collaboration: Cambridge University; St. Mary’s Hospital Medical School, London; Glasgow University; University of Sheffield; University of Wales College of Medicine; University College, London; Beatson Institute for Cancer Research, Glasgow. Key sales market contracts: Baxter Healthcare Corp. — LM-CD45 to prevent graft rejection. Key license and trade contracts: Cambridge University; Oxford University; Salk Institute; Cancer Research Campaign Technology; British Technology Group; Imperial Cancer Research Fund; Stanford University. Technological expertise: F, Q, RD, P/S, H/CF, C/TC Principal products/instrumentation: Biologicals, pharmaceuticals. Main products/instrumentation under R&D: Leukocyte modulators: LM-CD45 for prevention of graft rejection; TA-HPV: treatment of cervical cancer; TA-HSV for prevention of genital herpes recurrence; TA-GW for treatment of genital wart recurrence.

626 CAPITAL HPLC LIMITED Add: East Mains Industrial Estate Broxburn, West Lothian Scotland EH52 5NN UK Tel: (44) 0150-685-8505

open tubular and packed capillaries, vast range of HPLC packing materials, any internal diameter of S.S. Peek, Titanium, etc., columns — electrochromatography and capillary, electrophoresis. Sealed and granted patents: Smart column tracker, cartridge designs.

627 CAPRICORN PRODUCTS, INC. Add: 301 U.S. Route 1 Scarborough, ME 04074 Tel: (207) 885-0480 Fax: (207) 885-0494 E-mail: [email protected] Web site: www.capricornproducts.com President: Jane K. Havey R&D expertise: Development, production and supply of immunodiagnostic reagents (bulk raw materials). Technological expertise: PA Principal products/instrumentation: Goat Polyclonal antiserum for nephelometric/ turbidimetric assays; Monoclonal antibodies, polyclonal antibodies, purified antigens for immuno-chemistry and infectious disease, cellular research products. Main products/instrumentation under R&D: Immunodiagnostic reagents.

Fax: (44) 0150-685-8506 E-mail: [email protected] Web site: www.capital_hplc.co.uk President: Dr. Youssef Ghaemi Research director: Dr. Iain Grant R&D expertise: R&D and manufacture of CE, CEC, Spe and other accessation columns, vials, lamps etc.

628 CAPRION PHARMACEUTICALS, INC. Add: 5375 Pare St., Suite 201 Montreal, QC H4P 1PT Canada Tel: (514) 940-3600

Technological expertise: P/S

Fax: (514) 874-9077

Principal products/instrumentation: HPLC columns and cartridges, peek products, capillary

E-mail: [email protected] Web site: www.caprion.com

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President/CEO: Lloyd Segal Research director: Harry Ledebur, Ph.D. R&D expertise: Development and manufacture of diagnostics, prion diseases therapeutics and Alzheimer’s disease diagnostics/ therapeutics.

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630 CAPTAIR NIEDERLASSUNG DEUTSCHLAND DER ERLAB D.I.S. Add: Postfach 25 03 66 Koeln 50519 Germany Tel: (49) 211-39-5041 Fax: (49) 211-39-82215

R&D collaboration: University of Zurich, McGill University, University of Toronto.

E-mail: [email protected]

Key license and trade contracts: IDEXX Pharmaceuticals (Veterinary).

President: Francois-Pierre Hauville

Web site: www.erlab-dfs.com

Technological expertise: PA, C/TC

Research director: Roberto Zavagno

Principal products/instrumentation: Diagnostics, vaccines, reagents, prion testing in blood, Alzheimer’s disease, mouse model.

R&D expertise: Research of gene amplification, related therapeutical drug development.

Main products/instrumentation under R&D: Prion disease diagnostics; therapeutics; Alzheimer’s disease diagnostics/therapeutics.

Principal products/instrumentation: Instrumentation PCR Workstations, BIOCAP; ductless fume hoods, Captair; storage cabinets, Captairstore; laminar flow cabinets, Flowcap.

Sealed and granted patents: Several patents have been filed worldwide including patents for Caprion’s prion reagents, prion receptor and antibodies; AD diagnostics.

Technological expertise: GA

631 CARBOMER, INC. 629 CAPTAIR LABX

Add: P.O. Box 721 Westborough, MA 01581 Tel: (508) 870-0806

Add: 1980 Turnpike Street North Andover, MA 01845 Tel: (978) 975-3336 Fax: (978) 975-2730 E-mail: [email protected] Web site: www.erlab-dfs.com President: Francois Hauville R&D expertise: Ductless Filtering Fume Hoods. Technological expertise: BME Principal products/instrumentation: Ductless fume hoods, Toxicap; Vented storage cabinets, Captairstore; Ductless fume hoods, Filtair; Laminar Flow Hoods, PCR workstations, filtering shelf.

Fax: (508) 898-0432 Web site: www.carbomer.com President/CEO: Manssur Yalpani Research director: Manssur Yalpani R&D expertise: Research and development of specialty biochemicals, functionalized carbohydrate polymers, PEGs, biodegradable products. Technological expertise: CB, SY Principal products/instrumentation: Biologicals, bioconjugates, biomaterials, contract research products, diagnostics, over 65 unique functionalized biopolymers for bioconjugates, drug delivery and other biomaterial applications.

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632 CARDINAL ASSOCIATES Add: P.O. Box 5220 Santa Fe, NM 875025220 Tel: (505) 473-0033 Fax: (505) 473-5637 E-mail: [email protected]

Principal products/instrumentation: Coagulation monitors and consumables, diagnostics, biosensors. Main products/instrumentation under R&D: Thrombolytic therapy monitoring assays, clinical trials; fibrinogen assay, preclinical trials; whole blood immunoassays, research and development.

Web site: www.Cardinal-sf.com President/CEO: Ross U. Robinson Research director: Thomas Tucker R&D expertise: Cell function diagnostics research and manufacture of products that measure the function of living cells and their relationship to important medical conditions. Technological expertise: P/S, C/TC Principal products/instrumentation: Biologicals, contract manufacturing products, diagnostics, instrumentation, reagents, veterinary NIM; FLYTE ATP; NIM & ZAP; FLYTE 400 Luminometer; MagNIM; Arab NIM. Main products/instrumentation under R&D: Cell function diagnostics.

633 CARDIOVASCULAR DIAGNOSTICS, INC.

634 CARGILLE LABORATORIES, INC. Add: 55 Commerce Rd. Cedar Grove, NJ 07009-1289 Tel: (973) 239-6633 Fax: (973) 239-6096 President: John J. Cargille Research director: William J. Sacher R&D expertise: Development and production of lab-size products for laboratory. Technological expertise: BME Principal products/instrumentation: Refractive index and density stds., optical liquids, immersion oils, mounting media, disposable plastic and paper beakers, sample storage systems, tissue file boxes, microslide file boxes, albumin products, Stabilur tablets.

Add: 5301 Departure Dr. Raleigh, NC 27616 Tel: (919) 954-9871 Fax: (919) 954-9932 Web site: www.pharmaceutics.com

635 CARINA CHEMICAL LABORATORIES, LTD.

President/CEO: John Funkhouser

Add: P.O. Box 30366 18 Peterkin St. Lower Hutt 6315 New Zealand

Research director: Jonathon Laurie

Tel: (64) 4-567-9534

R&D expertise: Development and production of medical devices/diagnostics.

E-mail: [email protected]

R&D collaboration: Knoll, Lilly, Bayer. Key sales market contracts: Dade, Ortho, Avecor. Technological expertise: RD, CH/S

CEO: Ian J. Miller, Ph.D. R&D expertise: Research, development and manufacture of natural product extractions, marine colloids, biomass conversion and other articles of laboratory.

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Key license and trade contracts: New Zealand Pharmaceuticals, Ltd.; Sports Essentials Ltd. Technological expertise: BA, P/S, CB Principal products/instrumentation: Agarose technology, licensed, skin application gel. Main products/instrumentation under R&D: Agarose with gel melting above 100oC; polysubstituted phycocolloids, agar extraction technology.

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Technological expertise: C/TC Principal products/instrumentation: Cellbased biosensors, controlling insulin releasing devices.

638 CAROLINA BIOLOGICAL SUPPLY COMPANY Add: 2700 York Road Burlington, NC 27215 Tel: (800) 334-5551

636 CARMEL BIOSENSORS, LTD. Add: MATAM Center Bldg. 20 Haifa 31905 Israel

Fax: (800) 222-7112 Web site: www.carolina.com President: Peter Tourtellot

Tel: (972) 4-855-0850

Research director: Dr. Ray Flagg

Fax: (972) 4-855-0857

R&D expertise: Research of genomics, gene amplification and recombinant DNA; related biotechnology products manufacture.

E-mail: [email protected] President: Prof. Yoram Palti Research director: Prof. Yoram Palti R&D expertise: Applied development and manufacture of biosensors for blood glucose level monitoring. R&D collaboration: Circe Biomedical Inc. (WA). Technological expertise: C/TC Principal products/instrumentation: Biosensors, diagnostics. Main products/instrumentation under R&D: Blood glucose level monitors plans, clinical.

Joint ventures: DNA Learning Center — PCR Products; Kansas State University — Yeast genetics; National Center for Biotechnology Education (England — Exploring Electrophoresis Series). Technological expertise: Q, RD, GA, G Principal products/instrumentation: Biologicals, minerals, reagents, exploring electrophoresis series; PCR Kits; Transformation Kits; Yeast Genetics. Main products/instrumentation under R&D: New PCR Kits, New Transformation Kits, recombinant DNA products, gene amplification technology.

637 CARMEL BIOTECHNOLOGY, LTD. Add: P.O. Box 9667 Haifa 31096 Israel Tel: (972) 4-513-921 Fax: (972) 4-521-295 President: Prof. Yoram Palti R&D expertise: Development of cell-based biosensors for measuring blood sugar level and the controlling insulin releasing devices, and related products manufacture.

639 CARRINGTON LABORATORIES, INC. Add: 2001 WalnutHiU Ln Irving, TX 75038 Tel: (972) 518-1300 Fax: (972) 518-1020 Web site: www.carringtonlabs.com President/CEO: Carlton E. Turner, Ph.D.

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Research director: Dr. Kenneth M. Yates, D.V.M.

641 CARTESIAN TECHNOLOGIES, INC.

R&D expertise: Research, development and manufacture of nutraceuticals, wound repair and skin care products.

Add: 17851 Sky Park Circle, Ste. C. Irvine, CA 92614

Technological expertise: I, AF, CB, D-D, DD Principal products/instrumentation: Biologicals, contract manufacturing, products, natural products, nutraceuticals, CARRASYN hydrogel wound dressing; CARALOE Classic; Carraklenz wound and skin cleanser; Carrasorb Freeze-dried Gel. Sealed and granted patents: 120 patents held; Pectic substance as a growth factor stabilizer, 6,274,548, U.S.

640 CARR SEPARATIONS, INC. Add: 10 Forge Park Franklin, MA 02038-3057 Tel: (508) 553-2400

Tel: (949) 440-3680 Fax: (949) 622-0255 E-mail: [email protected] Web site: www.cartesiantech.com President/CEO: Tom Tisone Research director: Don Rose R&D expertise: Development and manufacture of applied equipment to automate and increase process efficiencies for the pharmaceutical and agricultural research and development markets. Technological expertise: COC, HTDS, G, R Principal products/instrumentation: Microfluidic dispense/aspiration platforms for HTS, nQUAD; Arraying platforms for genomics.

E-mail: [email protected]

Main products/instrumentation under R&D: Equipment to automate and increase process efficiencies for drug research.

Web site: www.carrsep.com

Subsidiary bodies: Durham, North Carolina.

President/CEO: Joe Oldfield

Sealed and granted patents: Apparatus and process for nanoliter dispense/aspirate.

Fax: (508) 553-2401

Research director: Bret Can R&D expertise: Development and manufacture of high speed centrifuges for benchtop to production scale separations. R&D collaboration: UCL, London, UK. Key license and trade contracts: Distributors worldwide. Technological expertise: P/S Principal products/instrumentation: Powerfuge high-speed centrifuges. Main products/instrumentation under R&D: Improved centrifuges for separation of mammalian and insert cells, high speed centrifuges for benchtop, benchtop microcentrifuge. Sealed and granted patents: Centrifuge apparatus.

642 CASCADE BIOLOGICS, INC. Add: 4475 SW Scholls Ferry Rd. Portland, OR 97225 Tel: (800) 778-4770 Fax: (503) 292-0566 Web site: www.cascadebio.com President: Gary Shipley, Ph.D. Research director: Rurt Droms, Ph.D. R&D expertise: Research of cell and molecular biology products, related biotechnology products manufacture. Technological expertise: C/TC

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Principal products/instrumentation: Wide selection of normal human cells, growth media, and electrophoresis devices. Main products/instrumentation under R&D: Cell adhesion molecule, cell surface receptor, molecular cloning. Sealed and granted patents: Antibodies to a YYX epitope of a mammalian prion protein, 7,041,807, U.S.

643 CATALYS AG Add: Industriestrasse 28 Wallisellen 8304 Switzerland

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R&D expertise: Analytical technology research, optical purity determination of organic compounds, amino acid analysis, and combinatorial chemistry research. Technological expertise: CC, COC, CH/S, R Principal products/instrumentation: Amino acid analyzer, DLAA1 Hydrolysis station AHSTI. Main products/instrumentation under R&D: Synthesizer for combinatorial chemistry, optical purity detector of organic compounds. Subsidiary bodies: Vorrichtung zur multiplen, gleichzeitigen und paralielen Synthese chernischer verbindungen and DE4115847 Al Mehrwegeventif.

Tel: (41) 1-830-7037 Fax: (41) 1-830-5578 President: Dr. Jurg Gysi Subsidiary of Promega Corporation, USA R&D expertise: Marketing and sales of bioproducts. Key sales market contracts: Promega, Serva, Molecular Bio-Products, Turner Designs, Hybaid, Biosmart. Technological expertise: Q, E, PA, T, TE, RD, P/S, GA, C/TC, SY, D-D, GT, HTDS Principal products/instrumentation: Biologicals, plastics, reagents, instrumentation, in vitro toxicology testing products, diagnostics.

644 CAT. GMBH & CO. CHROMATOGRAPHE UND ANALYSENTECHNIK KG Add: Heerweg 10 Tuebingen D-72070 Germany Tel: (49) 0-7071-78323 Fax: (49) 0-7071-75163 E-mail: [email protected] Web site: www.cat-online.com President: Dr. Jurgen Gerhardt

645 CATO RESEARCH, LTD. Add: 4364 S. Alston Ave. 200 Westpark Corporate Center Durham, NC 27713-2280 Tel: (919) 361-2286 Fax: (919) 361-2290 E-mail: [email protected] Web site: www.cato.com/interweb/cato President/CEO: Allen Cato, M.D., Ph.D. Research director: Walker Long R&D expertise: Commercialization of novel drug products developed by pharmaceutical and biotechnology companies from laboratory to market. Technological expertise: CH/S, DD Principal products/instrumentation: Contract research novel drug products, pharmaceutical development R&D in U.S., Canada, Europe: preparation of regulatory submissions; design, conduct, and reporting of Phase I–III clinical studies; liaison with FDA; design and execution of regulatory and product development strategy. Main products/instrumentation under R&D: Preclinical, clinical and regulatory development

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of drugs and biologicals: immunomodulators, sedative hypnotics, blood substitutes, platelet replacements, radiosensitizers, anti-cancer, anti-AIDS. Subsidiary bodies: CatoPharma Canada, Inc., Montreal, Quebec; Cato Research Israel, Tel Aviv, Israel; Cato Denver, CO, USA; Cato Washington (D.C.).

646 CAVIDI TECH AB Add: Uppsala Science Park Uppsala 75183 Sweden Tel: (46) 18-55-2040 Fax: (46) 18-55-2041

President: Angeline Milbank Subsidiary of Tecan AG R&D expertise: Design, development and manufacture of OEM precision liquid handling equipment. Technological expertise: R Principal products/instrumentation: Contract manufacturing products, reagents, XL 3000 Modular Digital Pump; XP 3000 Modular Digital Pump; MSP 9000 Mini Sample Processor; XL3000 Syringe Pump; XP3000 Syringe Pump; MSP 9250 Mini Sample processor; MSP 9500 Mini Sample Processor. Main products/instrumentation under R&D: OEM precision liquid handling equipment.

E-mail: [email protected] Web site: www.cavidi.com

648 CAYMAN CHEMICAL CO.

President: Mr. Kurt Ryde Research director: Simon Gronowitz R&D expertise: Research and development of applied diagnostic assays for retrovirus specialized on reverse transcriptase (RT), and manufacture of related diagnostic products.

Add: 1180 E. Ellsworth Rd. Mn. Arbor, MI 48108 Tel: (800) 364-9897 Fax: (734) 971-3640 E-Mail: [email protected]

Technological expertise: GA, DK

Web site: www.caymanchem.com

Principal products/instrumentation: Diagnostics, CAVIDI HS Kit LENTI RT, 1999; CAVIDI HS Kit Mn RT; CAVIDI HS Kit Mg RT; CAVIDI HS Kit HTLV RT.

President: Dr. Kirk Maxey

Main products/instrumentation under R&D: Diagnostic assays for retrovirus specialized on reverse transcriptase.

647 CAVRO SCIENTIFIC INSTRUMENTS, INC. Add: 242 Humboldt Ct. Sunnyvale, CA 94089 Tel: (408) 745-7400 Fax: (408) 745-0309 E-mail: [email protected] Web site: www.cavro.com

Research director: Dr. Rao Maddipati R&D expertise: Research, development and manufacture of high quality research biochemicals including eicosanoids, nitric oxide reagents, lipids, fatty acids, enzymes, antibodies, cDNA probes; assay kits for eicosanoids, cyclic nucleotides, cytokines, hormones; assays for high throughput screening applications. Customized chemical synthesis available upon request. Key sales market contracts: Chemdex; SciQuest. Key license and trade contracts: University of Michigan, Northwestern University, Taisho Pharmaceutical. Technological expertise: PA, HTDS, P/S, SMC, SY

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Principal products/instrumentation: Biomaterials, contract manufacturing products, enzymes, reagents antibodies. Main products/instrumentation under R&D: Other high quality research biochemicals.

649 CBD TECHNOLOGIES, LTD.

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include regulation of plant properties by modulating cell wall characteristics.

650 C-C BIOTECH CORP. Add: 28472 Cepin Dr. Valley Center, CA 92082 Tel: (760) 751-2413

Add: P.O. Box 199 2 Pekeris St., Park Tamar Rehovot 76100 Israel Tel: (972) 8-931-9550 Fax: (972) 8-931-9515 E-mail: [email protected] Web site: www.cbdtech.com President/CEO: Dr. Stanley Hirsch R&D expertise: Development, manufacture and commercialization of cellulose binding domain (CBD)-based applications in bioseparation, bioprocessing, plant growth regulation and protein production in plants, specialty regents for paper manufacturing and modification, novel formulations for the delivery of brocides, cellulose-immobilized enzymes for biocatalytic processes.

Fax: (760) 751-2679 E-mail: [email protected] President: Peter M. Cooper R&D expertise: Biotechnology medicines development, consulting and new adjuvants manufacture. Technological expertise: PA, BA, C/TC, H/CF, PIS Principal products/instrumentation: Biologicals, reagents, antibodies, enzymes, natural products, vaccines, Gerbu Adjuvant.

651 CCS PACKARD Add: 2841 Lomita Blvd. Torrance, CA 90505

Technological expertise: E, F, PA, Q, T, BA, CB, C/TC, CH/S, G, GA, HTDS, PIS, P/S, RD

Tel: (310) 530-1414

Principal products/instrumentation: CBinD™ L-Antibody purification.

E-mail: [email protected]

Main products/instrumentation under R&D: Modulation of plant growth rate and characteristics; specialty protein-based reagents for paper manufacturing; cellulose binding domain in drug research. Subsidiary bodies: CBD Technologies, Ltd., an Agbio company. CBD agbio, focuses on yield and growth properties, which are modulated through modification of plant cell wall properties. Sealed and granted patents: 14 issued U.S.A. patents for CBDs and applications thereof. Patents include compositions of matter, methods and applications. Plant growth patents

Fax: (310) 530-0530 Web site: www.ccspackard.com President: Richard Carl Subsidiary of Packard Bioscience Company R&D expertise: R&D of laboratory automation equipment for drug discovery genomics and life science research; manufacture related laboratory articles. Technological expertise: Q, G, HTDS, P/S, R Principal products/instrumentation: PlateTrak automated microplate processing systems for 96-, 384-, and 1536-well microplate formats; Plate Wash™, microplate washer for 96- and 384-well formats for standard and cell based plate washing; PlateStak™ microplate

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handler; SideTrak™ robotic arm for integration of peripheral microplate devices; CCS Microplatelid, universal microplate lid with or without spacers; Automated Bar code Print Apply. Main products/instrumentation under R&D: Small volume dispensing, integrated systems of microplate processing for genomic, instrument automation for high throughput screening, compound library management and ELISAs.

652 CEBRAL Add: P.O. Box 3376 Sarasota, FL 34230-3376 Tel: (941) 923-3268 Fax: (941) 923-5579

R&D expertise: Development of fermentation, cell culture technology, microbiology, bioengineering products downstream processing, drying technology, process measurement and control, computer interfacing, software applications, lab and pilot plant design and start-up, GLP or cGMP implementation. Technological expertise: F, P/S, BA, C/TC, CH/S, PMC Principal products/instrumentation: Biologicals, biomaterials, bioremediation, biosensors, natural products, biopharmaceuticals, process validation. Main products/instrumentation under R&D: Fermentation/cell culture technology, bioengineering products down stream processing, lab and pilot plant design.

E-mail: [email protected] President/CEO: Dr. Charles E. Berkoff Research director: Dr. Charles E. Berkoff

654 CEDARLANE LABORATORIES, LTD.

R&D expertise: Pharmaceutical and biotechnology medicines development/consulting.

Add: 5516-8th Line, R.R. 2 Hornby, ON LOP 1E0 Canada

Technological expertise: CC, E, P/S, R, SMC, SY, AF, AB, BI, CB, COC, D-D, HTDS, PIS

Tel: (905) 878-8891

Principal products/instrumentation: Agriculture, biologicals, biomaterials, contract research products, cosmetics, detergents, diagnostics, instrumentation, natural products, nutraceuticals, pesticides, pharmaceuticals, process validation, other biotechnology medicines.

653 CEBTECH SERVICES Add: 2735 Rice St., Ste. 107 Roseville, MN 55113 Tel: (612) 484-3377 Fax: (612) 484-3335 E-mail: [email protected] President: Craig Bremmon

Fax: (905) 878-7800 E-mail: [email protected] Web site: www.cedarlanelabs.com President: C. Greer Research director: E. Johnson R&D expertise: Research, development and manufacture of cell/tissue culture, monoclonal and polyclonal antibodies and blood substitutes. Technological expertise: K, PA, P/S, C/TC, BS Principal products/instrumentation: Transplants/culture, reagents, contract manufacturing products, enzymes, lympholyte, Low-Tox Complement, monoclonal and polyclonal antibodies for haemostasis and biomedical research, blood plasma substitutes.

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657 CELGENE CORP.

Add: 8609 Cross Park Dr. Austin, TX 78754

Add: 128 Sidney St., Cambridge, MA 02139

Tel: (512) 834-7766

Tel: (617) 649-9234

Fax: (512) 834-1165

Fax: (617) 649-9251

E-mail: [email protected]

President: Sol. J. Barer, Ph.D.

Web site: www.cedracorp.com

R&D expertise: Manufacturing and development of chiral molecules as active substances or intermediates for use in the pharma and agrochem industries.

President/CEO: David B. Garcia, Ph.D. Research director: Enrique Chacon, Ph.D. R&D expertise: Biotechnical medicines research contract services and supply of products for the pharmaceutical industry and the U.S. federal government. Technological expertise: CC, C/TC Principal products/instrumentation: HepCyte primary hepatocyte culture kits, and other biotechnical medicines.

656 CELERA AGGEN Add: 1756 Picasso Ave. Davis, CA 95616-0549

Technological expertise: CC, E, F, Q, SY, BA, D-D, GA, P/S, RD, SMC Principal products/instrumentation: Contract manufacturing products, Synovir, immunomodulator; various chiral chemicals; lenalidomide (Revimid), 2006. Main products/instrumentation under R&D: Chiral molecules as active substances or intermediates; Phase II study of ACE-011 for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer, 2009.

Tel: (530) 297-3000 Fax: (530) 756-5143 E-mail: [email protected] Web site: www.aggen.com

658 CELLABS PTY, LTD.

President/CEO: Stephen N. Bates

Add: 7/27 Dale St., Brookvale Sydney, NSW 2100 Australia

Research director: Marc Malandro

Tel: (61) 02-9905-0133

Subsidiary of PE Corporation R&D expertise: Development of comprehensive programs in agricultural genomic discovery and high throughput genotyping directed toward crop and livestock improvement, related products development. Technological expertise: Q, T, BI, C/TC, CH/S, GA, G, P/S, RD, R, CB, T Principal products/instrumentation: Genomic Discovery Systems; Marker Assisted Selection/ backeross; Plant Fluorescent databasing; Canine/Bovine Pedigree Validation, DNA PawPrints/Hoofprints.

Fax: (61) 02-9905-6426 E-mail: [email protected] R&D expertise: Specializes in the development of immunodiagnostic kits for infectious diseases. Technological expertise: PA, P/S, C/TC Principal products/instrumentation: ELISA kits for laboratory large-scale testing; fluorescent antibody (IFA microscope-based tests). Main products/instrumentation under R&D: Immunodiagnostic kits for infectious diseases.

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659 CELL APPLICATIONS, INC. Add: 6191 Cornerstone Ct. E. #108 San Diego, CA 92121 Tel: (858) 453-0848 Fax: (858) 453-2862

Sealed and granted patents: 3 held; 7 pending.

661 CELLCO, INC.

E-mail: [email protected]

Add: 23022 La Cadena Dr. Laguna Hills, CA 92653-1362

Web site: www.cellapplications.com

Tel: (949) 581-3500

President: Caroline Yu

Fax: (949) 581-3500

Research director: Caroline Yu

E-mail: [email protected]; spectrumlabs.com

R&D expertise: Research, development and manufacture of normal human/animal cell culture, contract drug project research.

spectrum@

Web site: www.cellco.com; www.spectrumlabs. com

Technological expertise: C/TC

President/CEO: Roy Eddleman

Principal products/instrumentation: Contract manufacturing products, contract research products.

Research director: Jesus Martinez

Main products/instrumentation under R&D: Normal human cell cultures, normal animal cell cultures, media, reagents.

660 CELL BASED DELIVERY, INC. Add: Four Richmond Square Providence, RI 02906 Tel: (401) 454-3540 Fax: (401) 454-3157 E-mail: [email protected] Web site: www.CBD-biotech.com President: Herman H. Vanderburgh, Ph.D. Research director: Herman H. Vanderburgh, Ph.D. R&D expertise: Drug delivery technology research. Technological expertise: BI, C/TC, COC, DD, D-D, GA, GT, PG, TE, SMC, RD Main products/instrumentation under R&D: Biological, biomaterials, biosensors, drug delivery technology and devices, preclinical.

R&D expertise: Development and manufacture of cell culture apparatus, cell therapy apparatus, cell and tissue culture. R&D collaboration: Haemonetics, Asahi Medical. Key sales market contracts: Life Technologies, Inc. Technological expertise: H/CF, C/TC, GT Principal products/instrumentation: Cellmax artificial capillary cell culture systems for mammalian cell culture, expansion of lymphocytes, and expansion of hematopoietic stem cells for human therapy; gene transductions contract products. Sealed and granted patents: Serum free production of packaged viral vector.

662 CELL CONTROL INCORPORATED Add: 157 Bedford Rd. Lincoln, MA 01773 Tel: (617) 259-8776 Fax: (617) 259-8776 President: Sol Aisenberg, Ph.D. Research director: Dr. Laszlo Egyud

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R&D expertise: Research, development and manufacture of ultra-small molecules drug to inhibit AIDS.

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President/CEO: Frederick J. Darfler Research director: Frederick J. Darfler

R&D collaboration: WHO.

R&D expertise: Design, development and manufacture of serum free and protein free powdered tissue culture media.

Technological expertise: O, PIS, SMS

Technological expertise: C/TC

Principal products/instrumentation: Pharmaceuticals, anti-AIDS agent.

Principal products/instrumentation: ABC (hybrodoma medium); ABY (yeast medium); Wine creator; Beer and Wine starters, EZ Wine.

Joint ventures: NCI.

Main products/instrumentation under R&D: Ultra-small molecules drugs to inhibit AIDS.

663 CELLEGY PHARMACEUTIACLS, INC. Add: 349 Oyster Point Blvd., Suite 200 South San Francisco, CA 94080 Tel: (650) 616-2200 Fax: (650) 616-2222 Web site: www.cellegy.com President/CEO: K. Michael Forrest Research director: Dr. John Dietrich R&D expertise: Research and development of topical prescription drugs, drug delivery technology and high-performance cosmeceuticals; related products manufacture. Key license and trade contracts: University of California. Technological expertise: DD Principal products/instrumentation: C99 Moisturizer. Main products/instrumentation under R&D: Anogesic, Phase III/IV, Testosterone Gel, Phase III/IV; Glylorin, Phase II/III; drug delivery technology, preclinical.

664 CELL ENTERPRISES, INC. Add: P.O. Box 41 Elkton.VA 22827 Tel: (540) 298-0114 Fax: (540) 298-0114

Main products/instrumentation under R&D: Serum free and protein free powdered tissue culture media.

665 CELLEX BIOSCIENCES, INC. Add: 8500 Evergreen Blvd. Minneapolis, MN 55433 Tel: (612) 786-0302 Fax: (612) 786-0915 E-mail: [email protected] Web site: www.cellexbio.com President: Bernard Horwath, VP, General Manager R&D expertise: R&D of cell and tissue culture, advanced cell culture technology and pharmaceutical, diagnostic and biotechnology medicines. Major partners: LSL Biolafitte. Technological expertise: F, BA, C/TC, P/S, LP, PMC Principal products/instrumentation: ResCuminiMAX; Research and GMP contract manufacturing products, monoclonal antibodies, biologicals, single cell proteins, recombinant proteins, cells, cellular extracts. AcuSyst-XCELL, AcuSyst-Maximizer,  AcuSyst-S, APS, AcuSyst-R ,   ResCuPrimer , ResCu-Multitech , Hollow, Fiber Bioreactors, Oxygenators, Microspheres, Ceramic Core Bioreactors, Helapare, Cell culture and production.

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Subsidiary Switzerland.

bodies:

France,

England,

Main products/instrumentation under R&D: Microbioreactor, Acusyst-PC control. Sealed and granted patents: Acusyst-EC Space Cycling, Microbioreactor.

666 CELL GENESYS, INC. Add: 500 Forbes Blvd., South San Francisco, CA 94080 Tel: (650) 266-3200 Fax: (650) 266-3241 President/CEO: Stephen A. Sherwin, M.D. Research director: Daniel F. Hoth, M.D. R&D expertise: Research and development of human therapeutics applications for gene targeting and gene transfer technologies; related drug products manufacture.

retroviral mediated transudation of mammalian cells. 6,506,604, U.S.; Cell-specific adenovirus vectors comprising an internal ribosome entry site. 6,692,736, U.S.; Retroviral gene therapy vectors and therapeutic methods based thereon. 6,44,771, U.S.; Human and mouse uroplakin II gene transcriptional regulatory elements. 6,852,528, U.S.; Compositions comprising tissue specific adenoviral vectors. 7,001,764, U.S.; Adeno-associated virus capsid immunologic determinants. 6,498,244, U.S.; Adenovirus packaging cell lines. 7,132,284, U.S.; Recombinant AAV vectors for gene therapy of hemophilia A. 6,797,505, U.S.; Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof, U.S.; Use of suppressor tRNA’s to regulate cytotoxicity during the production of recombinant gene products. 6,586,208, U.S.; other patents are pending.

667 CELLMARK DIAGNOSTICS

Joint ventures: JT Immunotech, products based on human MAbs.

Add: 20271 Goldenrod Lane Germantown, MD 20876

Key license and trade contracts: MedImmune, HIV antibodies to be used with cytotoxic T cell transplant products; Dana-Farber Cancer Institute, cell adhesion molecule, LAM-1; AKZO, follicle-stimulating hormone.

Tel: (301) 428-4980

Technological expertise: Q, T, F, P/S, RD, GA, HTDS, C/TC, CH.S, DD, GT

Technological expertise: RD, G, GA

Main products/instrumentation under R&D: Human cell transplant products, Phase I/II; human monoclonal antibodies, Phase I; geneactivated proteins, Phase I; GVAX prostate cancer (cancer vaccine) Phase III, 2008; retroviral gene therapy vectors, preclinical; three new clinical trials for GVAX immunotherapy for leukemia, 2008. Sealed and granted patents: Vector constructs. 7,109,029, U.S.; Adenovirus vectors containing cell status-specific response elements and methods of use thereof. 6,900,049, U.S.; Method for production of high titer virus and high efficiency

Fax: (301) 428-4877 President: Daniel D. Gamer, Ph.D. Research director: Robin W. Cotton, Ph.D. R&D expertise: DNA identification testing in cases of disputed paternity and forensic investigation, related novel products manufacture. Principal products/instrumentation: DNA probes for identification and parentage testing. Main products/instrumentation under R&D: DNA identification testing in case of disputed paternity.

668 CELLON Add: 204-route d’Arlon Strassen L-8010 Luxembourg

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Tel: (352) 312-313 Fax: (352) 311-052 E-mail: [email protected] Web site: www.cellon.lu President: Richard P. Fry R&D expertise: Research and development of industrial tissue culture; related products manufacture. Key sales market contracts: Newport Biosystems, Immunovision, Solohill Laboratories, In vitro Scientific Products, Synthecon, Kimble/Kontes, PBML/Greiner.

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Main products/instrumentation under R&D: Exisulind, Phase III completed, in FDA; CP461, Phase 1; CP248, predinical; aptosyn exisulind for colon multiple adenoma, Phase III/IV, 2008; drug products to prevent and treat cancer, preclinical.

670 CELLPRO, INC. Add: 22215 26th Ave S.E. Bothell, WA 98021 Tel: (206) 485-7644 Fax: (206) 485-4787

Key license and trade contracts: In vitro Scientific Products, Newport Biosystems, PBML.

President/CEO: Richard D. Murdock

Technological expertise: TE, F, GT, P/S, C/TC, BA, R

R&D expertise: Research of biotechnology cell separation and manipulation for therapy, diagnosis and research.

Principal products/instrumentation: Cell culture roller bottles and flasks, microcarriers, media bags, glassware and stirrer systems; autoimmune reagents and kits; specialized antisera and disease state plasma; bioreactors; automated roller bottle processor. Main products/instrumentation under R&D: Large-scale media, storage and harvesting systems for use with Bioreactors, vial leak tester.

669 CELL PATHWAYS

Research director: S. Joseph Tarnowski

R&D collaboration: Cell Genesis, Amgen. Key license and trade contracts: Fred Hutchinson Cancer Research Center. Technological expertise: P/S, HTDS, C/TC, GT, COC Principal products/instrumentation: Organ transplants/culture products, CEPRATE SC stem cell concentrator and CERRATE LS lab cell separator. Main products/instrumentation under R&D: Biotechnology cell separation for therapy and diagnosis.

Add: 702 Electronic Drive Horsham, PA 19044 Tel: (215) 706-3800

671 CELL ROBOTICS, INC.

Fax: (215) 706-3801 Web site: www.cellpathways.com President/CEO: Robert J. Towarnicki Research director: Rifat Pamukcu, M.D. R&D expertise: Research, development and commercialization of drug products to prevent and treat cancer. Technological expertise: SMC, C/TC, COC, HTDS

Add: 2715 Broadbent Parkway, NE Albuquerque, NM 87107 Tel: (505) 343-1131 Fax: (505) 344-8112 E-mail: [email protected] Web site: www.cellrobotics.com/cell President/CEO: Ronald K. Lohrding, Ph.D. Research director: Jerome Conia, Ph.D.

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Subsidiary of Cell Robotics International Inc.

673 CELL SIGNALING TECHNOLOGY

R&D expertise: R&D, manufacturing and marketing of laser-based medical devices and research instruments.

Add: 166 B Cummings Center Beverly, MA 01915

Key license and trade contracts: AT&T optical trapping patent.

Fax: (978) 867-2400

Technological expertise: T, C/TC, CH/S, P/S, HTDS

Web site: www.cellsignal.com

Principal products/instrumentation: LaserTweezers, LaserScissors™, CellSelector, SmartStages™, Cell Robotics Workstation, Lasette™ IVF Workstation. Main products/instrumentation under R&D: Lasette finger perforator, IVF workstation and skin resurfacing laser, MCR laser technology. Sealed and granted patents: Exclusive license for AT&T optical trapping patent; MCR laser technology.

672 CELL SCIENCES, INC.

Tel: (978) 867- 2300 E-mail: [email protected] President/CEO: Dr. Michael Comb R&D expertise: Development of bioreagents for cell signaling research; focus on antibodies to activated enzymes. Technological expertise: PA, RD, C/TC, HTDS, P/S Principal products/instrumentation: Biologicals, reagents, Phosphorylation State-specific antibodies; Context-independent phosphoantibodies; Cleaved caspase-specific antibodies; Non-radioactive kinase assay kits; antibodies to activate enzymes.

674 CELLS RBEST

Add: 1504 Providence Highway No. 1 IB Norwood, MA 02062

Add: 2813 LaGrange Circle Boulder, CO 80303

Tel: (781) 769-0610; (888) 769-1246

Tel: (303) 440-6657

Fax: (781) 769-0542

President: G. W. Dan, Ph.D.

E-mail: [email protected]

R&D expertise: Research and development of cell-based potency bioassays for biotech products.

Web site: www.cellsciences.com President: Irwin Libeskind R&D expertise: Development of immunochemicals and kits for life science research. Key sales market contracts: Diaclone Research, Hycult Biotechnology, GroPep. Technological expertise: PA, TE, C/TC, RD Principal products/instrumentation: Cytokine ELISA Kits; Endotoxin Reagents; Monoclonal and Polyclonal Antibodies; Erythropoetin, a cytokine that stimulates erythroid precursors to generate red blood cells, 2007.

Technological expertise: C/TC Principal products/instrumentation: Contract research/products, biopharmaceuticals, bioassay. Main products/instrumentation under R&D: Cell potency bioassays for biotech products.

675 CELL SYSTEMS CORP. Add: 12815 N.E. 124th St. Suite A. Kirkland, WA 98034

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cell and gene therapy, vector design and construction.

CEO: Carl Soderland Research director: John S. Veres, Ph.D. R&D expertise: Research, development and manufacture of mammalian cell culture reagents and human cell culture systems. Technological expertise: C/TC Principal products/instrumentation: Biologicals, reagents, proprietary cell culture systems: endothelial, smooth muscle, keratinocytes; human venous, arterial, and microvascular endomelial cell systems. Main products/instrumentation under R&D: Site-specific cell cultures, extracellular matrix systems for cell culture; Stretched™ Extended Lifespan human cell lines; mammalian cell culture.

676 CELLTEC GMBH BIOTECHNOLOGIE Add: Frohmestrasse 110 Hamburg 22459 Germany Tel: (49) 40-55905-730 Fax: (49) 40-55905-100 E-mail: [email protected]

677 CELLTECH GROUP PLC Add: 216 Bath Rd. Slough, Berk SL1 4EN UK Tel: (44) 753-534655 Fax: (44) 753-536632 E-mail: [email protected] Web site: www.celltech.co.uk CEO: Peter Fellner, Ph.D. Research director: Melanie Lee R&D expertise: Development and manufacture of antibody and small molecule therapeutics in cancer and inflammatory diseases. R&D collaboration: AHP, Merck & Co., Bayer, Schering Plough, Zeneca. Technological expertise: RD, P/S, BA, H/CF, C/TC, SY, D-D Main products/instrumentation under R&D: Contract manufacture of therapeutic proteins, antibody conjugates for cancers, anti-TNF, anti-cytokine, PDE-inhibitor, metalloprotease inhibitor, VLA4 inhibitors, Anti PDGF Mab. Sealed and granted patents: “Boss” Antibody Manufacture.

Web site: www.celltec.de President: Dr. Detlef Strathmann R&D expertise: Research of cell and gene therapy, vector design, vector production.

678 CELL TOOLS Add: 1777 Rollins Rd. Burlingame, CA 94010

R&D collaboration: Heinrich-Pelte-Institute, Hamburg; University Hospital Eppendorf, Hamburg.

Tel: (650) 777-4288

Technological expertise: C/TC, GA, GT, P/S

E-mail: [email protected]

Principal products/instrumentation: Organ transplants/culture products, vaccines.

President/CEO: Thomas L. Gross

Main products/instrumentation under R&D: Retroviral vectors for: a) stem cell production, Phase II/III (1/2000): b) adoptive immunotherapy;

Fax: (650) 777-1203

R&D expertise: Development and marketing of unique products and services to the biotechnology industry. Technological expertise: CH/S

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Principal products/instrumentation: Contract manufacturing products, contract research products, enzymes, antibodies, vaccines, 40/gas transfer and sensors.

Fax: (410) 455-5851 E-mail: [email protected] Web site: www.cell-works.com President/CEO: Charles Wheatley/Paul O. P. Ts’o, Ph.D.

679 CELL TRANSPLANTS INTERNATIONAL, LLC. Add: 2015 Miller Farms Rd. Germantown, TN 38138 Tel: (901) 753-0706 Fax: (901) 751-1808 E-mail: [email protected] Web site: www.cti.bio.com President: Peter Law, Ph.D. R&D expertise: Research and development of myoblast transfer therapy to treat neuromuscular diseases, diabetes, cancer, cardiomyopathy, bone/cartilage degeneration, hemophilia, hepatitis B, anemia, human growth hormone deficiency, bioprocess engineering products. Technological expertise: TE, T, LP, BA, C/TC, GT, H/CF Principal products/instrumentation: Myoblasts, cell (products). Main products/instrumentation under R&D: Myoblast transfer therapy, Phase III clinical trials on Duchenne muscular dystrophy and other muscular dystrophies; agnostics, organ transphants/ culture products. Sealed and granted patents: U.S. patent No. 5,130,141 Compositions for and methods of treating muscle degeneration and weakness. Pending: Myoblast therapy for mammalian diseases.

680 CELL WORKS, IMC. Add: University of Maryland-Baltimore Country 5202 Westland Blvd. Baltimore, MD 21227 Tel: (410) 455-5852

Research director: Paul O. P. Ts’o, M.D. R&D expertise: Cell and tissue culture; development of reference clinical lab tests detecting and characterizing circulation cancer cells. Principal products/instrumentation: Isolation/characterization of circulating cancer cells. Main products/instrumentation under R&D: Clinical lab testation for isolation/characterization of circulating breast cancer, colon cancer, kidney cancer. Sealed and granted patents: Exclusive license for Johns Hopkins patent for the above test.

681 CELLZ DIRECT Add: 7739 E. Broadway #346 Tucson, AZ 85710 Tel: (520) 790-4252 Fax: (520) 790-4286 Web site: www.CellzDirect.com President: Louis R. Breton Research director: Yutaka Sagara, Ph.D. R&D expertise: Research of cell aggregation and distribution, cell differentiation, cell lines, cellular information and related bioreagents for the advancement of scientific discovery. Technological expertise: HTDS, TE, C/TC, PG, BC, PA, P/S Principal products/instrumentation: Reagents, organ transplants culture, contract research products. Main products/instrumentation under R&D: Cell aggregation, distribution and differentiation technologies.

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682 CELOX LABORATORIES, INC. Add: 1311 Helmo Ave. St. Paul, MN 55128

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Main products/instrumentation under R&D: Biocontrol treatments of seed, bioprocess novel technology of crops and the seeds.

Tel: (615) 730-1500 Fax: (615) 730-8900

684 CEL-SCI CORP.

E-mail: [email protected] Web site: www.celox.com President/CEO: Milo R. Polovina Research director: Milo R. Polovina R&D collaboration: Hoxworth Blood Center — University of Cincinnati, Medical Center, Memorial Blood Center — Minneapolis, MN, University of Minnesota, American Type Culture Collection. Key sales market contracts: Funakoshi Co. Ltd. Japan, ICN Pharmaceuticals, worldwide. Technological expertise: H/CF, C/TC, DD Principal products/instrumentation: TCM, TM-235, TCH Cellvation, serum-free media and cell biology products, cell lines preadapted to serum-free media. Main products/instrumentation under R&D: Viastem, in vitro fertilization products. Sealed and granted patents: Viastem.

683 CELPRIL Add: 251 Oak St. Manteca, CA 95337 Tel: (209) 823-1738 Fax: (209) 823-8855

Add: 8229 Boone Blvd., Ste. 802 Vienna, VA 22182-2634 Tel: (703) 506-9460 Fax: (703) 506-9471 E-mail: [email protected] Web site: www.cel-sci.com President: Maximilian de Clara Research director: Eyal Talor, Ph.D. Subsidiary of Viral Technologies, Inc. R&D expertise: Development of new therapeutics vaccines against cancer and infectious diseases. R&D collaboration: NCI, NIAID, U.S. Navy, Northeastern. Ohio Universities, College of Medicine, University of Nebraska. Technological expertise: C/TC, PIS, D-D, SY Main products/instrumentation under R&D: Multikine for treatment of cancer, Phase III cancers; HGP-30W AIDS vaccine, Phase III; HGP- 30 for AIDS treatment, Phase II; Tuberculosis, Malaria and Herpes and other infectious diseases vaccines in preclinical development. Sealed and granted patents: Patents issued in the U.S. and major countries on all products (composition of matter).

Web site: www.celpril.com CEO: Roger L. Repp (General Manager)

685 CELSIS INTERNATIONAL PLC

Research director: John Walsh Subsidiary of Aventis Crop Science R&D expertise: Research of bioprocess development technology. Principal products/instrumentation: RhizoKote; Nutri-Kote; Cel Gard, 1996; Cel Pass.

Add: Cambridge Science Park Milton Road Cambridge CB4 0FX UK Tel: (44) 1223-426008 Fax: (44) 1223-426003 Web site: www.celsis.com

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President/CEO: Jack Rowell

Tel: (44) 012-94-848484

Research director: Peter Grant

Fax: (44) 012-94-848486

R&D expertise: Development, manufacture and sales of Rapid Microbial Testing Systems.

E-mail: [email protected]

Technological expertise: BME, ERT, G

Research director: Dr. David Fuller

Principal products/instrumentation: Rapid Microbial Testing Systems (hygiene monitoring, fruit juice, water and dairy).

R&D expertise: Research and development of drug delivery, related products manufacture.

686 CELSUS LABORATORIES, INC. Add: 12150 Best Place Cincinnati, OH 452411569 Tel: (513) 772-8130 Fax: (513) 772-8132 E-mail: [email protected]

CEO: Dr. Dan Roach

R&D collaboration: Norgine Key sales market contracts: Schwarz Pharma UK Technological expertise: DD Principal products/instrumentation: Morphine Rectal Delivery System (“MRDS”); Metronidazole Hydrogel Pessary, Vaginal Antifungal Pessary; OSAT Nifedipine. Main products/instrumentation under R&D: Other drugs delivery systems.

Web site: www.heparin.com President: Cornelius L. Van Gorp Research director: Alan D. Cardin, Ph.D. Technological expertise: BA, CB, P/S, SY Principal products/instrumentation: Heparin Sulfate 1 (CL-03105); Heparin salts (ammonium, benzalkonium, calcium, lithium, sodium); Low Molecular Weight Heparins (nitrous-acid deaminated, Centaxarin DH, CL-03250 periodate-oxidized, Centaxarin PO, CL-03260); Dermatan sulfate derivatives; Heparan sulfate derivatives; Heparin salts. Main products/instrumentation under R&D: Low molecular weight heparins (ardeparin sodium, Centaxarin, ML-009723 de-N-sulfated heparin, Centaxarin PD, CL-03240); Heparin Cofactor II-Catalysts (galnacuronans, Intimatan, CL-03135 periodate oxidized galnacuronans, Intimatan RD, CL-03360).

687 CENES DRUG DELIVERY, LTD. Add: Riverside Way Riverside Business Park Irvine, Ayrshire KA11 5DJ UK

688 CENES LIMITED Add: Compass House, Vision Park Olivers Way, Histon Cambridge CB4 9ZR UK Tel: (44) 012-23-266466 Fax: (44) 012-23-266467 E-mail: [email protected] Web site: www.cenes.com President: Alan Goodman Research director: Terry Smith R&D expertise: Research and development/ manufacture of therapeutical drugs for central nervous system and cognitive test systems. R&D collaboration: Novo Nordisk, Denmark; King’s College London; Cambridge University; University of Lausanne, Switzerland; University of Durham; Glaxo Wellcome. Technological expertise: SMC, C/TC, CH/S, D-D, HTDS, R Principal products/instrumentation: CANTAB cognitive testing system, CHANNELWORK ion channel research services.

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Main products/instrumentation under R&D: Alzheimer’s therapeutics (research), Parkinson’s (research), morphine 6-glucoronide (Phase II), Schizophrenia (Phase II), Analgesic Peptides (preclinical); Stroke therapeutics (Phase II), therapeutical drugs for CNS, preclinical. Sealed and granted patents: Schizophrenia, Analgesia, Alzheimer’s Disease, Parkinson’s Disease, High Throughput Screening, Process Chemistry.

689 CENTAUR PHARMACEUTICALS, INC. Add: 484 Oakmead Parkway Sunnyvale, CA 94086 Tel: (408) 822-1600 Fax: (408) 822-1601 Web site: www.centpharm.com President/CEO; Brian Frenzel R&D expertise: Therapeutical drugs development of neurodegenerative diseases, inflammatory disease conditions, diseases of aging. Technological expertise: COC, D-D, HTDS, SMC, SY Main products/instrumentation under R&D: Contract research products, cosmetics, nutraceuticals, Therapeutics: acute stroke, Phase III; Parkinson’s disease, Phase III; AIDS Dementia Complex, Phase II; Alzheimer’s disease, preclinical; Arthritis, preclinical.

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President: Rolf Benzian Research director: David Tesin R&D expertise: Free up pentapharm products: serine protease inhibitors (AESBF and Aprotinin), chromogenic and fluorogenic substrates, snake venom proteins and Prionex, The BSA Alternative for the stabilization of proteins. Exclusive distributor of DiverDrugs, S.L., offering: peptide, protein and small organic molecule combinatorial libraries; computational chemistry, novel drug delivery systems; and custom synthesis of combinatorial libraries, peptides, proteins and drug-like molecules. Technological expertise: E, F, BA, C/TC, DD, COC, D-D, HTDS, PTS, PMC, P/S, SMC, SY Principal products/instrumentation: Pefabloc Series of Serine Protease Inhibitors (AEBSF, Aprotinin), Pefachrome Series of Chromogenic and Fluorogenic Substrates, Snake Venom Proteins (Reptilase) and Prionex, The BSA Alternative from Pentapharm, Ltd. Diverse-Quest Lead Discovery Products and Services from DiverDrugs, S.L.

691 CENTER FOR ADVANCED TECHNOLOGY (CAT) IN BIOTECHNOLOGY Add: 130 Biotechnology Bldg. Cornell University Ithaca, NY 14853-2703 Tel: (607) 255-2300 Fax: (607) 255-6249 Web site: www.research.cornell.edu/biotech/

690 CENTERCHEM, INC. Add: 225 High Ridge Rd. Stamford, CT 06905 Tel: (203) 975-9800 Fax: (203) 975-8777 E-mail: [email protected] Web site: www.centerchem.com

President: Lynn W. Jelinski Research director: Richard D. Holsten R&D expertise: Education of scientific and biotechnology. Technological expertise: SM, SY, E, F, PIS, RD, PA, Q, T, AF, AV, VI, CB, C/TC, CH/S, DD, H/CF, P/S, GA, D-D

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Principal products/instrumentation: Biologicals, biomaterials, bioremediation, biosensors, natural products, vaccines, enzymes, peptides, reagents, antibodies.

692 CENTOCOR, INC. Add: 200 Great Valley Pkwy Malvern, PA 19355 Tel: (610) 651-6000

disease with anti-TNF antibodies. 7,128,907, U.S.; Methods for treating systemic lupus erythematosus using anti-TNF antibodies and fragments thereof. 7,128,908, U.S.; Methods for treating sarcoidosis using anti-TNF antibodies and fragments thereof. 7,135,179, U.S.; Formation of novel erythropoietin conjugates using transglutaminase. 6,995,245, U.S.; Methods of treating rheumatoid arthritis with antiTNF antibodies. 7,138,118, U.S.(2002–2008); others pending.

Fax: (610) 651-6100 Web site: www.centocor.com President/CEO: David P. Holveck Research director: James Woody, M.D. R&D expertise: Development of diagnostic and pharmaceutical products based on monoclonal antibodies, related products manufacture. Key sales market contracts: Eli Lilly & Co., ReoPro and diagnostic test kits; Glaxo Wellcome, Panorex; Abort, Roche, Boeringer Mannheim. Technological expertise: GT Principal products/instrumentation: 7E3 RenPro, antiplatelet antibody for angioplasty, (U.S. and Europe); 171A Panorex, adjuvant therapy for colorectal cancer, (Germany); CA125 II, ovarian cancer monitor (U.S. and Europe); Myoscint, imiciromab pentetate, monoclonal contibody for cardiopathy diagnostic; Reopro (abciximab); Remicade (infliximab) for crohn; Retavase (reteplase) for acute myocardiac infarction. Main products/instrumentation under R&D: CA2, CenTNF, anti-inflammatory antibody; I2D10, Corsevin-M, anti-factor VII Mab; golimuab (Humira), III, 2008; CNTO 1275, treat psoriasis, Phase II/III, 2008; Gene Vax, gene vaccine for breast cancer, lung cancer. Subsidiary bodies: Leiden, The Netherlands; Tokyo, Japan. Sealed and granted patents: Chemically defined medium for cultured mammalian cells. 6,900,056, U.S.; Methods of treating Crohn’s

693 CENTRAL BIOMEDIA, INC. Add: 9900 Pflumm, Suite 63 Lenexa, KS 66215 Tel: (913) 541-0090; (800) 448-0016 Fax: (913) 541-1712 E-mail: [email protected] President: William G. Skelly R&D expertise: Development and production of bulk animal sera; custom processing of serum products for biologics manufacture and diagnostics. Technological expertise: P/S Principal products/instrumentation: Donor horse serum, Donor Goat serum, Donor Bovine serum. Main products/instrumentation under R&D: New honor animal sera. Subsidiary bodies: 425 West “V” Hwy, Irwin, MO 64759. Sealed and granted patents: Methods of making and using immunoglobulin (lg) compositions. 6,770,278, U.S.

694 CENTRE D’IMMUNOLOGIE PIERRE FABRE Add: 5 Avenue Napoleon III Saint-Julien en Genevois Cedex 74164 France

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Tel: (33) 450-35-3555 Fax: (33) 450-35-3590 E-mail: [email protected] Web site: www.cipf.com President: Pierre Fabre Research director: Jean-Yves Bonnefoy R&D expertise: Research, development and production of biotech medicine products. Technological expertise: BI, DD, GA, PIS, P/S, BA, SY, F, PA, Q, TE, T Main products/instrumentation under R&D: Recombinant subunit RSV vaccine, Phase III, Sep 2000; PrV3, preclinical; Hanta-virus, research.

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Joint ventures: Cangene, Ipsen, Actinova, Alizyme, SR Pharma and others. Principal products/instrumentation: Erwinase; Dysport; Anthroy Vaccine; toxin therapeutics. Main products/instrumentation under R&D: Analgesic with Allergen, Preclinical; various vaccines to infectious diseases, preclinical; program of microbial hazard high containment microbiology.

696 CENTRITECH AB Add: Kumla CardsVag 13 Norsborg 14563 Sweden Tel: (46) 8531-89540 Fax: (46) 8531-83050

695 CENTRE FOR APPLIED MICROBIOLOGY AND RESEARCH (CAMR)

E-mail: [email protected] President: Stig Apelman Research director: Christer Lantz

Add: Porton Down Salisbury, Wiltshire SP4 OJG UK

R&D expertise: Development of separation systems for laboratory drug research.

Tel: (44) 1980-612100

Joint ventures: Dupont Medical Products.

Fax: (44) 1980-612291

Technological expertise: P/S

E-mail: [email protected] Web site: www.camr.org.uk

Principal products/instrumentation: Centritech cell separation system; Centritech Lab separation system.

President: Roger Gilmour, Ph.D. Research director: Charles Penn, Ph.D. Subsidiary of UK Dept. of Health R&D expertise: Research, development and production of microbial hazard-high containment microbiology; production of vaccines, biologics and bioprocess engineering products. R&D collaboration: Allergan. Key sales market contracts: Ipsen Ltd., Soar Erwinase & Dysport.

697 CEPHALON, INC. Add: 45 Brandywine Pkwy. West Chester, PA 19380 Tel: (510) 344-0200 Fax: (610) 344-0065 E-mail: [email protected] Web site: www.cephalon.com

Key license and trade contracts: Allergan, Zycos, Oxford Bio-Medica.

CEO: Frank Saldino, Jr., Ph.D.

Technological expertise: BI, BA, C/TC, GA, P/S, H/CF, RD, LP, F

R&D expertise: Drug discovery, development and marketing of innovative products to treat

Research director: Jeffry L. Vaught, Ph.D.

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neurological disorders, sleep disorders and cancer.

Technological expertise: BI, C/TC, COC, DD, E, HTDS, R, SMC, SY, CH/S

Technological expertise: GT, D-D, CC/TC, RD

Principal products/instrumentation: Odyssey 5000, lead seeking chemistry library; BioPrint, biology and chemistry database.

Principal products/instrumentation: Provigil, Gabitrol; Fentora, 2006; armodafinil (Nuvigil), 2007. Main products/instrumentation under R&D: Orally-active, small molecules for the treatment of neurodegenerative diseases, one of which, CEP-1347, Phase II development; Compounds to treat prostate, pancreatic, and other cancers, one of which, CEP-701, Phase III clinical studies; myotrophin (mecarsermin), sclerosis; Phase III trial of Nuvigil (armodafinil) tablets [C-1V] as a treatment for excessive sleepiness associated with jet-lag disorder, 2009. Sealed and granted patents: Hydroxamatecontaining cysteine and serine protease inhibitors. 7,060,683, U.S.; Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs. 6,310,040, U.S.; other are pending.

Main products/instrumentation under R&D: Drug discovery process, supply solutions to the pharmaceutical industry allowing faster and more cost effective drug discovery by identifying at early stages compounds that will fail in development, technologies of combinational and medicinal chemistry, biology, in vivo and in vitro pharmacology, high throughput screening and profiling. Innovative pharmacoinformatic and chemoinformatic technologies such as the BioPrint database, tools and software. Subsidiary bodies: Cerep Inc. 15318 NE 95th St., Redmond, WA 98052, USA; Cerep, Le Bois Leveque, 86600 Celle L’Evescault, France.

699 CEREX, INC. 698 CEREP, SA.

Add: 12 Falmouth Rd. Wellesley, MA 02481 Tel: (781) 237-5606

Add: 128 rue Danton Ruiel-Malmaison 92500 France Tel: (33) 1-5594-8400 Fax: (33) 1-5594-84 10

Fax: (781) 239-0455 E-mail: [email protected] President: Randolph T. Hatch

Web site: www.cerep.fr

R&D expertise: Development and manufacture of instrumentation for process monitoring and control processes.

President/CEO: Dr. Thierry F. Jean

Technological expertise: F, BA, PMA

Research director: Dr. Frederic Revah, VP Drug discovery; Michael Entzeroth, VP New technologies.

Principal products/instrumentation: MAX optical density sensor for monitoring of fermentation processes.

E-mail: [email protected]

R&D expertise: Research and manufacture of drug discovery. Combinatorial chemistry high throughput screening (HTS) and profiling (HTP). Cosmetics, detergents, in vitro toxicology testing, natural products, nutraceuticals, small molecules drugs.

Add: 5504-102 Commercial Ave. Raleigh. NC 27612

R&D collaboration: Sanofi; Tibotec; BMS.

Tel: (919) 787-3989

700 CERTEK, INC.

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702 CHARLES RIVER LABORATORIES

E-mail: [email protected] Web site: www.certekinc.com President/CEO: James I. Grantham R&D expertise: Manufacture and development of airborne contamination control fumigation equipment, and BL3 laboratories. Principal products/instrumentation: Hazardous-Air Filtration system, SAFEMOD; BL3 Modular Laboratories; Formaldehyde Generators/Neutralizers, 1414RH. Main products/instrumentation under R&D: Airborne contamination control fumigation equipment. Sealed and granted patents: Formaldehyde Generators.

701 CETEK CORP.

Add: 251 Ballardvale St. Wilmington, MA 01887 Tel: (978) 658-6000 Fax: (978) 658-7132 E-mail: [email protected] Web site: www.criver.com President: James C. Foster Research director: Julie Palm Subsidiary of Bausch & Lomb R&D expertise: Bioprocess engineering development; breeding of laboratory animals, contract production of monoclonal and polyclonal antibodies, contract research including preclinical research small and large animals. Technological expertise: T, PA, P/S, BA, C/TC, PMC, LP, Bioanalytical testing, endotoxin testing.

Add: 260 Cedar Hill St. Marlborough, MA 01752

Principal products/instrumentation: Monoclonal antibodies.

Tel: (508) 229-8900

Main products/instrumentation under R&D: Breeding of new laboratory animals, R&D.

Fax: (508) 229-2344 E-mail: [email protected]

Subsidiary bodies: Charles River Tektagen; Charles River Endosafe (Dr. James Cooper).

Web site: www.cetek.com President: James L. Waters Research director: Dr. Dallas Hughes

703 CHARLES RIVER PHARMSEVICES, INC.

R&D expertise: Drug discovery, drug design and manufacture; proprietary screening technology development.

Add: P.O. Box 727 Southbridge, MA 01550

Technological expertise: SMC, BI, CH/S, G, HTDS, P/S, R

Fax: (508) 765-1288

Principal products/instrumentation: Biologicals, natural products, nutraceuticals, pharmaceuticals. Main products/instrumentation under R&D: Drug proprietary screening technology, drug discovery route.

Tel: (508) 765-9580 President: Robert F. Doolin Research director: Mel Balk, D.V.M. Subisdiary of Charles River Laboratories R&D expertise: Antibodies-custom development and production; Contract research of drug application in large animals; Animal housing;

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Custom research services; Medical device testing; Xeno-transplantation.

705 CHARM BIOENGINEERING, INC.

Technological expertise: PA, T, BA, HTDS, PIS

Add: 36 Franklin St. Maiden, MA 02148-4128

Principal products/instrumentation: Contract manufacturing products, contract research products, diagnostics, organ transplants/culture products, pharmaceuticals, reagents, vaccines.

Tel: (781) 322-1523

Main products/instrumentation under R&D: Custom antibodies, drug screening test in large animals.

Web site: www.charmbio.com

Fax: (781) 322-3141 E-mail: [email protected] President: Stanley Charm, Sc.D. Research director: Stanley Charm, Sc.D. Subsidiary of Charm Sciences Inc.

704 CHARLES RIVER THERION

Tel: (518) 286-0016

R&D expertise: Research of heat pasteurization for viral and microbial inactivation in heat sensitive materials, Sterilization of heat sensitive fluids.

Fax: (518) 286-0018

Joint ventures: Charm Sciences Inc.

E-mail: [email protected]

Technological expertise: B/P, E, BA, F, microwave viral inactivation (pasteurization) and sterilization of biological products.

Add: 185 Jordan Rd. Troy, NY 12180-7617

Web site: www.theriondna.com President: James Foster Research director: Nancy J. Casna, Ph.D. Subsidiary of Charles River Laboratories R&D expertise: DNA-based testing research of animals for addressing questions related to strain characterization, genetic monitoring, parentage verification, species/subspecies differentiation, genetic estimation within/among colonies and genetic relatedness within/among colonies; research and development contract work. Technological expertise: T, GA, P/S Principal products/instrumentation: Contract manufacturing products, proprietary multi-locus DNA-based probe series (OPT series); Genetic monitoring of transgenic and knockout animals including strain characterization, species/subspecies differentiation, paternity verification, zygosity and expression testing and Max-Bax. Main products/instrumentation under R&D: Marker to and/or determine performance/ production traits for companion animals and aquaculture, DNA-based testing.

Principal products/instrumentation: Microwave viral and microbial inactivator 80 liter/hr, Ultratherm, Enzymes, vaccines. Main products/instrumentation under R&D: A benchtop ultratherm, 30 liter/hr; sterilization of heat sensitive materials/fluids. Sealed and granted patents: 5,539,673; 4,839,142; 4,975,246; 5,389,335.

706 CHARTER MEDICAL, LTD. Add: 1805 Swartmore Ave. Lakewood, NJ 08701 Tel: (732) 901-9400 Fax: (732) 901-9405 E-mail: [email protected] Web site: www.chartermed.com President: Lisa Krallis-Nixon Research director: Dave Heagle Subsidiary of Lydall, Inc.

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R&D expertise: Research and development of blood bags, biopharmaceutical containers, related products manufacture.

Research director: Dr. P. Vessey

Technological expertise: BA

Technological expertise: BME, SI

Principal products/instrumentation: BioPak, Bio-Pak XL, BP-Mini, SA Sampling Device, Contour Tank Liners, Cryo-Pak.

Key license and trade contracts: Plymouth marine lab, aquashuttle towed vehicle, Southampton Oceanography Centre, SeaSoar towed vehicle.

Subsidiary bodies: Winston-Salem, NC.

707 CHEEZHENG TIBETAN MEDICINE CO., LTD. Add: Room 501, Beisihuan Donglu 131#, Beijing, China

R&D expertise: Design, development and manufacture of scientific instruments.

Principal products/instrumentation: Biosensors, contract manufacture products, microtitre tray; shaker, incubator. Main products/instrumentation under R&D: OEM instrumentation for third party clients ranging from prototype to pre-production.

Tel: (86) 10-6489-6688-255 Fax: (86) 10-6494-5110 E-mail: [email protected] Expert in R&D: The largest Tibetan medicine company in China, is one of the first 91 statelevel enterprises of scientific and technological innovation, R&D and manufacture of traditional Tibetan medicines.

709 CHEMAJET CHEMICAL COMPANY Add: 3 Idris Othman St., Elgeach Road, Mandara P.O. Box 84 Elsaray Alexandria Egypt Tel: (20) 3-555-3691; (20) 3-555-4138; (20) 4-773-2709; (20) 3-732923 Fax: (20) 3-548-6088

Expert in technologies: TTM, HNT

E-mail: www.chemajet.com

Principal products/instrumentation: Cheezheng Tibetan medicine pain relieving plaster (tablet) high therapeutic effect of temporarily relieving or aches and pains of muscles and joints.

President: Aladdin Hamdy

Subsidiary bodies: 4 GMP factories were built respectively in Tibet and Gansu Province.

Technological expertise: SY

708 CHELSEA INSTRUMENTS, LTD.

Research director: Dr. L. Tosson R&D expertise: Development and manufacture of diagnostic kits and laboratory fine chemicals. Principal products/instrumentation: Laboratory fine chemicals; Chemajet. Main products/instrumentation under R&D: Diagnostic kits.

Add: 2/3 Central Ave. West Molesey, Surrey KT8 2QZ UK Tel: (44) 18-1941-0044 Fax: (44) 18-1941-9319

710 CHEMBIOTECH, LTD.

E-mail: [email protected]

Add: Birmingham Research Park Vincent Dr. Birmingham, West Midlands B15 2SQ UK

Web site: www.chelsea.co.uk

Tel: (44) 121-414-7029

President: David Chatterton, M.B.E.

Fax: (44) 121-414-7030

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President/CEO: Dr. J. F. Kennedy Research director: Dr. C. J. Knill R&D expertise: Contract R&D of products in biotechnology, chemistry and biochemistry; related novel products manufacture. Technological expertise: E, Q, CB, PIS, P/S, SMC, BA, DD Principal products/instrumentation: Biologicals, biomass, biomaterials, bioremediation, contract research products, detergents, reagents, enzymes, antibodies, peptides, specialty chemicals.

711 CHEMGEN CORP. Add: 211 Perry Parkway, Gaithersburg, MD 20877-2144 Tel: (301) 330-4101

R&D expertise: Research, development and manufacture of chemical intermediates for DNA-RNA synthesis; biotechnology products; custom DNA-RNA; antisense products. Technological expertise: AB, SY, D-D Principal products/instrumentation: DNA synthesis phosphoramidites; RNA synthesis phosphoramites; antisense RNA synthesis phosphoramidites; diagnostics products; psoralen phosphoramidites, biotin phosphoramidites; DNA probes. Main products/instrumentation under R&D: New antisense products; DNA-based ultra sensitive diagnostic kits for various genes; chemical intermediates for DNA-RNA synthesis.

713 CHEMICAL COMPUTING GROUP, INC.

E-mail: [email protected]

Add: 1010 Sherbrooke Str. W Suite 910 Montreal, Quebec H3A 2R7 Canada

President: Bemhard L. Treidl

Tel: (514) 393-1055

R&D expertise: Research, development and manufacture of specialty animal feed ingredients.

Fax: (514) 874-9538

Technological expertise: F, E, RD

President/CEO: Paul Labute

Principal products/instrumentation: Hemicell Feed Enzyme.

Research director: Paul Labute

Fax: (301) 948-5866

Main products/instrumentation under R&D: Specialty animal feed ingredients.

712 CHEMGENES CORP. Add: 145 Newton St. Waltham, MA 02154 Tel: (617) 899-2959 Fax: (617) 647-3063 E-mail: [email protected]

E-mail: [email protected] Web site: www.chemcomp.com

R&D expertise: Research of software for drug design, life science/drug discovery software, novel products, development and production. Key sales market contracts: Ryoka Systems, Inc. (exclusive Japanese distributor). Technological expertise: CC, SY, RD, BI, R, Q, C/T, COC, CH/S, DD, D-D, G, HTDS, DG, SMC Principal products/instrumentation: MOE — the Molecular Operating Environment.

President/CEO: Suresh C. Srivastava, Ph.D.

Main products/instrumentation under R&D: Drug discovery software, drug design software.

Research director: Suresh C. Srivastava, Ph.D.

Sealed and granted patents: Binary QuaSAR, patent pending.

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714 CHEMICAL INFORMATION SYSTEM (THE CIS) Add: Executive Plaza 3, Ste. 1100 11350 McCormick Rd. Hunt Valley, MD 21031 Tel: (800) 247-8737

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Principal products/instrumentation: Biologicals, diagnostics, reagents, anticancer agents, vaccines, antibodies. Main products/instrumentation under R&D: Monoclonal and polyclonal antibodies for various diseases.

Fax: (410) 296-0712 E-mail: [email protected]

716 CHEMIE BRUNSCHWIG AG

Web site: www.oxmol.com/prods/cis President: Jane Hammel Research director: Maty Ann Hoffman Technological expertise: Research and development of computer hard ware/software, related products manufacture.

Add: Belchenstr. 12 Basel, CH 4009 Switzerland Tel: (41) 61-301-1555 Fax: (41) 61-301-1181 Web site: [email protected]

Technological expertise: CH/S

President: Andre Brunschwig

Principal products/instrumentation: Online Information Service databases in Chemistry/ Biology/Environment fields.

R&D expertise: Reagents development, manufacture and supply.

Main products/instrumentation under R&D: Computer hardware/software system.

715 CHEMICON INTERNATIONAL, INC. Add: 28835 Single Oak Dr. Temecula, CA 92590

Technological expertise: CC, F, PA, Q, SY, T, C/TC, COC, GA, H/CF, PIS, PG, P/S, RD Principal products/instrumentation: Organ transplant/culture, vaccines, lab reagents and chemicals. Main products/instrumentation under R&D: Various new reagents.

717 CHEMOS CZ, S.R.O.

Tel: (909) 676-8080 Fax: (909) 676-9209 E-mail: [email protected] Web site: www.chemicon.com President/CEO: David A. Beckman R&D expertise: Development and manufacture of monoclonal and polyclonal antibodies for infectious diseases; neuroscience, extracellular matrix, adhesion molecules, cytoskeletal signal transduction basic research and cancer research, related novel therapeutical drugs development. Technological expertise: PA, C/TC, HTDS

Add: Sterboholska 28 Prague 10 102 00 Czech Republic Tel: (420) 2-701-793 Fax: (420) 2-705-485 E-mail: [email protected] Web site: www.chemos-group.cz R&D expertise: Chemistry and biochemistry reagents development, products worldwide sales. Technological expertise: E, F, PA, RD, BI, SY, Q, BA, T, BS, CB, C/TC, COC, DD, GA, PIS, P/S, SMC

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Principal products/instrumentation: Agriculture, biologicals, biomaterials, specialty chemicals, clinical tests, contract manufacturing products, cosmetics, detergents, food processing, minerals, natural products, pesticides, pharmaceuticals, plastics, reagents, vaccines, veterinary products. Main products/instrumentation under R&D: Chemistry and biochemistry reagents.

718 CHEMOS GMBH Add: Werner-von-Siemens Str. 3 Regenstauf, Bavaria 93128 Germany Tel: (49) 9402-9336-20 Fax: (49) 9402-9336-13

Fax: (44) 1403-24885 E-mail: [email protected] Web site: www.chemovation.com CEO: Dr. Alan Stuttle Research director: Dr. Ian Matthews R&D expertise: Research and development of novel compounds and client-directed combinatorial libraries, related products manufacture. Key sales market contracts: Summit Pharmaceuticals International — Japan. Technological expertise: COC, D-D, SMC, SY Principal products/instrumentation: Contract research/clinical trials drug, pharmaceuticals, novel therapeutical compounds. Main products/instrumentation under R&D: Client-directed combinatorial libraries.

E-mail: [email protected] Web site: www.chemos-group.com President: Ulrike Lingher-Hoffman

720 CHEMQUIP, LTD.

Research director: Dr. Hoffman R&D expertise: Worldwide export, import trade with specialty chemicals, biochemicals, cell/tissue culture products and laboratory applied equipment.

Add: Chinley High Peak Stockport, Cheshire SK23 6AR UK Tel: (44) 1663-750000 Fax: (44) 1663-750953

Technological expertise: CC, F, CB, C/TC

E-mail: [email protected]

Principal products/instrumentation: Biosensors, chemicals, clinical tests, detergents, diagnostics, dextrane, saccharides, amino acids, nucleosides, nucleotides, dextrins, ribonucleic acids, luciferin, lecithine, tensides, thiophene and derivatives, methanethiosulfonate compounds, bio-polychemicals, n-dodecyl sulfate, sodium salt, chemiluminesence.

President: P. Cunningham

Main products/instrumentation under R&D: Nucleosides, nucleotides, specialty chemicals.

Main products/instrumentation under R&D: Fermenters, control equipment.

719 CHEMOVATION, LTD. Add: The Yammond, North Heath Lane Horsham RH12 5QE UK Tel: (44) 1403-248844

Research director: Dr. D. L. Cox R&D expertise: Development and manufacture of fermenters, valves, pumps, pipes, control equipment. Principal products/instrumentation: Pumps, Reactors, Mixers, UV-Vis Spectrometer (online).

721 CHEMRX ADVANCED TECHNOLOGIES Add: 385 Oyster Point Blvd., Ste. 1 South San Francisco, CA 94080

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Fax: (650) 829-1266

Quality management system to the ISO 9001 quality standard.

E-mail: [email protected]

Technological expertise: P/S, SY

Web site: www.chemrx.com

Principal products/instrumentation: Reference materials — highly purified and certified organic and inorganic chemicals. Solutions, mixtures and chemical kits and pesticide standards/reference materials.

President: Robert Reed, Ph.D. R&D expertise: Research, development and manufacture of combinatorial chemistry and medicinal chemistry products and services. Technological expertise: COC, SY, CC, P/S, D-D, PIS, SMC Principal products/instrumentation: Chemicals, contract research pharmaceuticals, vaccines, antibodies. Main products/instrumentation under R&D: Combinatorial chemistry products, medicinal chemistry products.

723 CHEMSYN LABORATORIES Add: 13605 W. 96th Terrace Lenexa, KS 66215-1297 Tel: (800) 233-6643 Fax: (913) 888-3582 E-mail: [email protected] Web site: www.chemsyn.com

722 CHEM SERVICE, INC. Add: 660 Tower Lane P.O. Box 599 West Chester, PA 19381-0599

President: James C. Wiley, Jr. Research director: Steve Greenwald Subsidiary of Eagle-Picher, Industries

Fax: (610) 692-8729

R&D expertise: Contract API development and manufacture specializing in cyntotovic and other high potency compounds.

E-mail: [email protected]

Technological expertise: SMC, SY

Web site: www.chemservice.com

Principal products/instrumentation: Confidential, contract manufacturing products.

Tel: (610) 692-3026

President: Dr. Lyle Phifer Research director: Dr. James Harris R&D expertise: Analytical reference materials (over 13,000), small quantities of organic chemicals. Provide the largest selection of neat pesticide standards. Wide range of small quantity (under 10 g), highly purified organic and inorganic analytical reference materials chemicals, solutions, custom solutions, mixtures and chemical kits, chemical synthesis, isomer separation, purification and certification. Extensive selection of standards includes EPA methods, ASTM methods, state-specific UST methods, international methods, petroleum hydrocarbon standards, FAME and vitamin standards.

Main products/instrumentation under R&D: Confidential lyntotoxin, high potency compounds. Subsidiary bodies: cGMP Bulk Manufacturing Plant, cGMP Process Development Plant.

724 CHENGDE JINGFUKANG PHARMACEUTICAL GROUP CO. LTD. Add: No. 9, Xia’erdaohezi, Chengde, Hebei, 067000, China Tel: (86) 03-14-215-3758 Fax: (86) 03-14-215-0923

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E-mail: [email protected] Web site: www.cdjfk.com.cn R&D expertise: R&D, manufacture and marketing of Traditional Chinese Medicines, including granules, capsules, oral liquid, tablets, mixture, tincture, pills, etc. Technological expertise: TCMM, HNT Principal products/instrumentation: National basic medicine as protected varieties of the Chinese herbal and patent medicines include: Neck Recovery Granule (activate blood circulation and remove obstruction in the channels. For relief of symptoms such as insufficient blood supply to the brain, dizziness, stiffness in neck and upper back, shoulder and back pain, and numbness of forearm caused by cervical spondylopathy); Yaotongning capsule (subdue swelling and relieve pain, expel pathogenic cold, promote the flow of qi by warming the channel. For treatment of prolapse of lumbar intervertebral disc, hyperosteogeny of lumbar vertebra, sciatica, lumbar muscle strain, lumbar myofibrositis, and chronic rheumatoid arthritis), Fufang shiwei tablet (clear away heat and drying dampness, inducing diuresis to improve stranguria. For treatment of oliguria, frequent micturition, urgency of urination, urodynia, edema in lower limbs, etc. Also for the treatment of acute or chronic glomerulonephritis, pyelonephritis, cystitis, and urethritis manifested with the abovementioned symptoms), Qinggong Changchun capsule, etc.

725 CHENGDU ENWEI INVESTMENT GROUP CO. LTD.

R&D expertise: R&D, manufacture and marketing of Traditional Chinese medicines. Technological expertise: TCMM, HNT Principal products/instrumentation: Competitive products including Howeko oral liquid (promote digestion, invigorate the spleen, promote qi and harmonize the stomach, indicated for anorexia in children due to stagnation of food); Oral Guard Gargle (clear heat and toxin, reduce swelling and stop pain, release swelling pain of gingivitis, pericoronitis and oral catarrh); Skinpro lotion (clear heat, eliminate dampness, kill parasites and stop itching, indication: leukorrhagia due to damp-heat manifested as itching and swelling of the pudendum, profuse, yellow or bean dregs-like vaginal discharge; thirst and bitter taste in the mouth, yellow urine and dry stools, mainly indicated for yeast infected or trichomonas vaginitis with the abovementioned symptoms). Skin diseases: acute eczema (dampheat pattern), contact dermatitis (toxic-heat with damp pattern), tinea corporis and tinea cruris (wind-damp-heat pattern); Skinpro feminine gel (feminine daily care, it offers a high sterilization rate over 99% against candida albicans, staphylococcus aureus and bacillus coli, and maintains the weak acid ecological environment of vagina, it contains unique natural herbal essences, mild in nature, without any irritation).

726 CHERWELL SCIENTIFIC PUBLISHING, LTD. Add: The Magdalen Centre Oxford Science Park Oxford 0X4 4GA UK Tel: (44) 018-6578-4800

Add: No. 28, Chungye Rd., Hi-tech zone, Chengdu, Sichuan 010041, China

Fax: (44) 018-6578-4801

Tel: (86) 28-8515-8581, (86) 28-8166-3333

Web site: www.cherwell.com

Fax: (86) 28-8515-7212, (86) 28-8166-5555

CEO: Tim Cook

E-mail: [email protected], callcenter@ enwei.com.cn, [email protected]

R&D expertise: Development, manufacture and supply of specialist software for scientists and engineers around the world.

Web site: www.enwei.com.cn

E-mail: [email protected]

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Technological expertise: CH/S

Tel: (949) 347-9640

Principal products/instrumentation: ModelMaker, a powerful Windows simulation modeling package designed for scientists and engineers, Cyrillic for drawing family pedigrees and managing genetic data.

Fax: (949) 347-9722

Subsidiary bodies: Cherwell Scientific Inc., 257 Great Road, Acton, MA 10720, USA, Tel: 1-888257-6652/(978) 263-6066; Fax: (978)-635-5330.

Research director: Frank Ahmann

727 CHESAPEAKE BIOLOGICAL LABORATORIES, INC.

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E-mail: [email protected] Web site: www.chimeric.com President/CEO: Olav B. Bergheim R&D expertise: Research and development of pharmaceutical techniques for cell and tissue engineering to induce tolerance in transplantation. Technological expertise: C/TC, GT, HTDS, P/S, TE

Add: 1111 South Paca St. Corporate and Commercial Division Baltimore, MD 21230

Principal products/instrumentation: Organ transplants/culture.

Tel: (410) 843-5000

Main products/instrumentation under R&D: Graft for mismatched bone marrow transplants, pivotal Phase II/III; Graft for tolerance induction, Phase I; chimeric bone marrow cell graft treat sickle cell disease, Phase III/IV, 2008.

Fax: (410) 843-4414 E-mail: [email protected] Web site: www.cblinc.com President/CEO: Thomas P. Rice Research director: Dr. Narlin Beaty R&D expertise: Contract development and manufacture of sterile biopharmaceuticals, fill and finish of small volume paneuterals; bioprocess engineering products. Joint ventures: Over 80 firms (large pharma to early-stage biotech companies). Technological expertise: Sterile liquid fill/finish, cGMP, ISO 9002, DD, P/S Principal products/instrumentation: Biologicals, contract manufacturing products, pharmaceuticals, process validation, vaccines, enzymes, monoclonal antibodies. Main products/instrumentation under R&D: Sterile biopharmaceuticals. Subsidiary bodies: 6000 Metro Dr. Baltimore, MD, 21215. 728 CHIMERIC THERAPIES, INC. Add: 28202 Cabot Rd., Suite 210 Laguna Niguel, CA 92677

Subsidiary bodies: Philadelphia, PA, USA; Munich, Germany. Sealed and granted patents: 4.

729 CHIMERX Add: 5520 W. Burleigh St. Milwaukee, WI 53210 Tel: (800) 626-7833; (414) 871-7199 Fax: (414) 871-1273 Web site: www.chimerx.com President: Peter Smyczek Research director: Peter Smyczek R&D expertise: Development and design of molecular biology kits, enzymes, synthetic oligonucleotides, related products manufacture. Technological expertise: Q, E, AB, RD, P/S, BA, SY Principal products/instrumentation: Restriction endonuclease, modifying enzymes, enzyme conjugates.

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Main products/instrumentation under R&D: Molecular biology kits, novel oligonucleotides.

730 CHINA BEIJING TONGRENTANG (GROUP) CO., LTD. Add: No. 52 Dongsinglong Rd., Xicheng District, Beijing, China Tel: (86) 10-0701-5895 E-mail: gfbgs@tongrentang. com Web site: www.tongrentang.com R&D expertise: Development and manufacture of life science and healthcare products of TCMM.

Subsidiary of China National Pharmaceutical Group Corporation R&D expertise: R&D plantation, manufacture and marketing of Traditional Chinese Medicine products. Technological expertise: CMH, TCMM Principal products/instrumentation: Plantation, trade and development of Chinese medicinal herbs, standardization of research and manufacture of sliced herbs for decoction, manufacture of finished Chinese traditional medicine.

732 CHIRAL SEP S.A.

Technological expertise: TCMM, HNT Principal products/instrumentation: Angong Niuhuang wan (pill), Tongren Dahuoluo wan (pill), Tongren Niuhuang Qingxin wan (pill), zixue, yufeng Ningxin Pian (tablet), Tongren wuji Baifeng wan (pill), Jufang zhibao wan (pill), Zaizao wan (pill), Niuhuang Jiedu pian (tablet) Xiaoshuan Zaizao wan (pill), Ganmao Qingre Keli (granule), Goupi Gao, Anshen Jian Nao ye, Huoxiang Qushu (soft capsule), etc. Subsidiary bodies: Ten holding subsidiaries, including two listed companies.

Add: Parc Boissiere La Frenaye 76170 France Tel: (33) 2-35-38-02-12 Fax: (33) 2-35-38-10-10 E-mail: [email protected] Web site: www.chiralsep.com President/CEO: Dr. Duval Rayhael Research director: Dr. Duval Rayhael Subsidiary of Orgasynth S.A. (FR) R&D expertise: Chiral technologies development, related products manufacture. Joint ventures: ASE and Bio (FR), J.V., with GOE-MAR (FR).

731 CHINA NATIONAL GROUP CORPORATION OF TRADITIONAL & HERBAL MEDICINE Add: No. 8001, Yisite Building, Xisihuan Beilu 15#, Haidian District, Beijing 100195, China Tel: (86) 010-8846-8006 Fax: (86) 010-8846-8075 E-mail: [email protected] Web site: www. sino-tcm.com

Key sales market contracts: Distributor for U.S.: Phenomenex (Chiral supports), Sochibo (SandF:/Syntheidbo-FR): Chiral products. Key license and trade contracts: In discussion. Technological expertise: CC, P/S Principal products/instrumentation: Cosmetics, natural products, nutraceuticals, pesticides, pharmaceuticals, mono-cyclodextrin derivative, Cyclose; chiral tridimensional network polymer, Chirose. Main products/instrumentation under R&D: Mono-carboxy cycloaextrin (preclinincal),

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Acarbose analogs (preclinical), chiral drug technologies.

E-mail: [email protected]

Sealed and granted patents: U.S. 6,042,723; EP 0899272; FR 98/11377; FR 97/16798; FR 97/16799; FR 97/16800; FR 00/01223; FR 00/01225; FR 00/04273.

President/CEO: Edward E. Penhoet, Ph.D.

733 CHIRAL TECHNOLOGIES, INC. Add: 730 Springdale Dr. P.O. Box 564 Exton, PA 19341 Tel: (610) 594-2100 Fax: (610) 594-2325 E-mail: [email protected] Web site: www.chiraltech.com President/CEO: Thomas B. Lewis Research director: Ron Bopp Subsidiary of Daicel Chemical Industries, Ltd. R&D expertise: Development and manufacture of enantiomeric chromatography products and services. Technological expertise: CC, P/S, SMC, SY Principal products/instrumentation: Contract manufacturing products, natural products, pharmaceuticals, CHIRALCEL, CH1RALPAK, and CROWNPAK, chiral HPLC columns and stationary phases cell. Subsidiary bodies: Chiral TechnologiesEurope SARL, Parc d’Innovation, B.P. 167, Bld. Gonthier d’Andernach, 67404 Illkirch, Cedex, France, Tel: (33) 388-79-5200, Fax: (33) 388-66-7166.

734 CHIRON CORP. Add: 4560 Horton St. Emeryville, CA 946082916 Tel: (510) 655-8730 Fax: (510) 655-9910

Web site: www.chiron.com Research director: Williams, Ph.D., M.D.

Lewis

T.

“Rusty”

R&D expertise: Research and development of diagnostic, vaccine and therapeutic strategies against diseases such as HIV, HCV and certain cancers, related products manufacture. Joint ventures: Novartis Technological expertise: AB, BI, C/TC, COC, DD, D-D, GT, RD, R, Q, SMC, SY Principal products/instrumentation: Blood screening tests for hepatitis C virus (HCV), critical blood analytes systems and random access immunoassay instrument systems and related reagents; Betaseron (recombinant interferon-α-1b) — for multiple sclerosis, Proleukin aldesleukin-interieukin-2 for metastatic kidney cancer and melanoma, Acelluvax — genetically engineered acellular pertussis vaccine; Vitraser — implant for localized treatment of CMV retinitis, and intraocular lenses for cataract replacement surgeries. Main products/instrumentation under R&D: Tifacogin (TFPI), cell factor for hematosepsis, Phase II–III, 2008; Proleukin (IL-2, aldes leukin), for HIV infection, cancer, acute leukemia, Phase III–IV, 2008; Fibroblast growth factor, coronary artery disease, Phase II–III, myotrophin insulin-like growth factor for the treatment of amyotrophic lateral sclerosis (Lou Gherig’s disease) and Regranex becaplermin recombinant (platelet-derived growth factor) for the treatment of diabetic skin ulcers, as well as vaccines for genital herpes, CMV and HIV; FIBLAST trafermin for cardiac disease, Phase III. Sealed and granted patents: Method of solubilizing, purifying, and refolding protein. 6,323,326, U.S. Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor. 7,022,672, U.S.

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735 CHIRON TECHNOLOGIES CENTER FOR GENE THERAPY

Web site: www.chiroscience.com President: Lord Henry Chilver Research director: Dr. Robert Jackson

Add: 11055 Roselle St. San Diego, CA 92121 Tel: (619) 452-1288 Fax: (619) 452-2616 E-mail: [email protected] Research director: Steven J. Mento, Ph.D. Subsidiary of Ciron Crop. R&D expertise: Gene therapy research, related novel products development. R&D collaboration: Green Cross Corp., HIV immunotherapeutics; Bayer, Hemophilia A gene replacement therapy. Key sales market contracts: Green Cross Corp., HTV immunotherapeutics; Bayer, Hemophilia A gene replacement therapy. Key license and trade contracts: Biogen, HBV gene for immunotherapy; Ajinomoto, IL2 gene to treat cancer; Genentech, gamma IFN to treat cancer. Technological expertise: F, Q, T, P/S, RD, BA, C/TC, CH/S, DD, D-D, GA, GT, PMC Main products/instrumentation under R&D: HTV, Phase III; Melanoma with Aldesleukin, Phase I; Melanoma, Phase I; Renal cell carcinoma, Phase I; Neuroblastoma, Phase I; Cancer using prodrug activation, preclinical; Gene immunotherapy for HBV, preclinical; Gene replacement therapy for Hemophilia A, preclinical; Cancer using IL-2, preclinical; Gamma IFN to treat cancer, preclinical.

736 CHIROSCIENCE GROUP PLC

R&D expertise: Discovery, design, development and manufacture of improved healthcare drug products, focusing on cancer, pain and inflammation. R&D collaboration: Knoll/BASF on Verapamil isomers; Medeva PLC on single isomer of methylphenidate. Acquired Darwin Molecular Corp. Dec 1996. Also: Collaboration with Schering-Plough on PDE IV Inhibitors for asthma; Alcon Labs to screen chiroscience compounds in Alton Screens for ophthalmic and other applications; Bristol Myers-Squibb for D2163/D1927 (MMPs); Schering-Plough for PDE IV inhibitor for asthma. Key sales market contracts: Chugai Boyeki to market Chiroscience’s technology services and products in Pacific rim area. Key license and trade contracts: Zeneca for Chirocaine. Technological expertise: CC, E, F, Q, COC, CH/S, D-D, HTDS, P/S, SMC, SY, BI Principal products/instrumentation: Dexketoprofen, launched as Enantyum, June 1996 by Partner Laboratorios Menarini in Spain; Lactam Main products/instrumentation under R&D: 01927, 02163 MMP Inhibitors for Cancer Research, Phase II; d-throo methylpheno, Phase III; dermal Powderject, Phase III; Lignocaine, PDEIV inhibitor for asthma, preclinical; D2024 (Verapamil isomer), Phase I; improved healthcare drug. Subsidiary bodies: Pilot Plant: Stevenage, Herts, UK; Seattle, WA, USA.

Add: Cambridge Science Park, Unit 283 Milton Road Cambridge CB4 4WE UK Tel: (44) 012-2342-0430 Fax: (44) 012-2342-0440 E-mail: [email protected]

737 CHONDREX, LLC. Add: 16149 Redmond Way Suite 410 Redmond, WA 98052

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Tel: (425) 702-6365 Fax: (425) 882-3094 E-mail: [email protected] Web site: www.chondrex.com President: Robert A. Reife, Ph.D. Research director: Robert A. Reife, Ph.D. R&D expertise: Arthritis Research and therapeutical biotechnology medicines development. R&D collaboration: FujiRebio, Inc., Biosupport, Inc. Key sales market contracts: IWAI Chemicals. Key license and trade contracts: Stratagene and MDS Panlabs. Technological expertise: PA, P/S, C/TC, HTDS, H/CF, P/S Principal products/instrumentation: Arthrogen-CIA Purified Collagen, ArthrogenCIA Human ELBA Kit to detect Type I and II collagen antibodies, Arthrogen-CIA Mouse ELISA Kit to detect Type I and II collagen Antibodies, Arthrogen-CIA Type II Collagen Capture Kit, Arthrogen-CIA Collagen Activity Kit, Arthrogen-CIA Arthritogenic Monoclonal Antibodies. Main products/instrumentation under R&D: Diagnostics for rheumatoid arthritis, currently in the R&D phase.

738 CHONGQING CREATIVE BIOTECH CO. LTD. Add: Keyuan 1 Road, No. 5, Shi Qiao Pu, Chongqing 400039, China

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R&D collaboration: Partnerships with Chinese Academy of Sciences; Chinese Authority for Biological Products Control (FDA of China). Key license and trade contracts: Import and export of pharmaceuticals licensed by the government. Technological expertise: PA, E, F, P/S, DD, PMC, P/S, BA, BS, CB, C/TC Principal products/instrumentation: Biosensors, reagents, vaccines, contract research/ clinical trial products, natural products, HSA, HCG, HMG. Main products/instrumentation under R&D: Antivirals, preclinical, GM-CSF; HSA from yeast, preclinical. Sealed and granted patents: Novel drug screening technology.

739 CHR-HANSEN A/S Add: 10-12 Boege Alle Hoersholm DK-2970 Denmark Tel: (45) 45-74-74-74 President: Poul Hansen Research director: Egon Bech Hansen R&D expertise: Research of enzymology, fermentation and carbohydrate biotechnology, related products development. Technological expertise: E, F, Q, CB, RD Principal products/instrumentation: Biologicals, biomass, enzymes, carbohydrate, biomaterials, bioremediation, natural products, contact development products.

Tel: (86) 23-6863-5457 Fax: (86) 23-6863-5456

740 CHRISOPE TECHNOLOGIES, INC.

President: Wang Xiao-Ruo Research director: Cui Taian

Add: 3941 Ryan St. Lake Charles, LA 70605

R&D expertise: Biopharmaceuticals development and manufacture.

Tel: (318) 479-1000; 1800-256-GERM Fax: (318) 479-1006

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President: Gerald L. Chrisope, Ph.D. Research director: Nell Roberts

Tests; Star Bright Fluorophores; Scanning Photon-counting Fluorometer.

R&D expertise: Development and manufacture of vaginal suppository and loops.

Main products/instrumentation under R&D: Fluorometer software and hardware.

Technological expertise: OC

Sealed and granted patents: Fluorophores and fluorophore chemistries, fluorometer software and hardware.

Principal products/instrumentation: CULTILOOPS and QUANTI-CULT, GermWare. Main products/instrumentation under R&D: Completion of Phase I SBIR grants from the NIH and CDC developing women’s health care vaginal lactobacillus suppository.

742 CHROMATOCHEM, INC. Add: P.O. Box 370 Missoula, MT 59806-0370 Tel: (406) 728-5897; (800) 426-7227

741 CHROMAGEN, INC.

Fax: (406) 728-5924 President/CEO: Richard F. Hammen, Ph.D.

Add: 10451 Roselle St. San Diego, CA 92121 Tel: (858) 558-1456 Fax: (858) 558-7166 E-mail: [email protected] Web site: www.chromagen.com President: Michael Conrad, Ph.D. Research director: Raymond Johnson, Ph.D. R&D expertise: Assay research and products manufacture using fluorescence detection technologies for pharmaceutical development. Joint ventures: Nalge/Nunc International — Microwell plates and target capture chemistries. R&D collaboration: CombiChem — drug discovery screening agreement; Labsystems Oy — Instrument manufacturer, distributor; Merck & Co. — Assay Development; Taisho Pharmaceuticals, Inc. Key sales market contracts: BioCare — Asian distributor; CN Biosciences/Orcogene Research Products — U.S. distributor. Key license and trade contracts: Merck Pharmaceuticals. Technological expertise: C/TC, G, HTDS, PG Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, HPSA Gene Expression

Research director: Richard F. Hammen, Ph.D. R&D expertise: Research of chromatographic separations in bioseparations and environmental remediation, related applied products development and manufacture. Technological expertise: P/S, BA, PMC Principal products/instrumentation: Toxic waste processing system, HiPAC columns for affinity chromatography, including protein A, protein G, aldehyde and hydrazine activated; columns for removal, concentration and separation of metal ions. Main products/instrumentation under R&D: Support for immobilized metal affinity chromatography; chromatographic separator in bioseparations and environmental remediation.

743 CHROMATOGRAPHY (CSC) SCIENCES Add: 5750 Vanden Abeele Montreal, Quebec H4S 1R9 Canada Tel: (514) 334-1892 Fax: (514) 334-1898 E-mail: [email protected]

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Web site: www.chromatographysciences. com

Web site: www.chromos.com

President: Michael Spain, Ph.D.

Research director: Jan I. Drayer, M.D., Ph.D.

R&D expertise: Development, manufacture and marketing of chromatography accessories.

R&D expertise: Research, development and commercialization of artificial chromosome technology for use in biopharmaceutical protein production, via transgenic and cellular systems, and gene therapy, manufacture of artificial chromosomes for gene-based products that would otherwise be difficult or impossible to produce due to the limitations of existing gene expression systems.

Technological expertise: DKHC Principal products/instrumentation: Columns for HPLC, CSC-SI, CSC-Vitesse, CSC-Seiect. Main products/instrumentation under R&D: Novel column for HPLC: CSC-Cc-tasil.

744 CHROMATO. SUD, AIRNOTEC Add: 15 Rue d’Antinguelengue Saint Antoine 33260 France Tel: (33) 055-796-0626 Fax: (33) 055-796-0620 E-mail: [email protected] Web site: www.chromatosud.com President: Franch Amiet Research director: Pascale Baumard R&D expertise: Development and manufacture of gas analyzer specialized in ambient air monitoring, natural gas, and LPG.

President/CEO: Alistair Duncan

R&D collaboration: Pharming Technologies BV, Chiron Corporation and Boehringer Ingelheim Pharma KG. Technological expertise: BA, C/TC, DD, GA, GT, T, HTDS, P/S, RD Main products/instrumentation under R&D: Artificial chromosomes, preclinical; transgenic animals, preclinical; cell lines for protein production, preclinical; mammalian artificial chromosomes. Sealed and granted patents: Mammalian artificial chromosomes; Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes, 6,743,967, U.S.A.

Technological expertise: F, PMC Principal products/instrumentation: Toxic waste processing system, suffer gas analyzer; BTX gas analyzer; Bio gas analyzer. Main products/instrumentation under R&D: Ambient air monitoring analyzer.

746 CHROMTECH, INC. Add: P.O. Box 240248 Apple Valley, MN 55124 Tel: (800) 822-5242 Fax: (952) 431-6345

745 CHROMOS MOLECULAR SYSTEMS, INC.

E-mail: [email protected] Web site: www.chromtech.com President: Steve Pierson

Add: 8081 Lougheed Highway Burnaby, BC V5A 1W9 Canada Tel: (604) 415-7100 Fax: (604) 415-7151 E-mail: [email protected]

R&D expertise: Development and manufacture of chromatography instrumentation and supplies. Key sales market contracts: Agilent, BioChrom, Varian, Hamilton, Vydac, Zirchrom.

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Technological expertise: CC, SMC, CB, PIS, P/S

Technological expertise: Q, SMC, C/TC, COC, CH/S, D-D, G, HTDS

Principal products/instrumentation: Peptide HPLC columns, Vydac; Chiral HPLC Columns, Chiral — AGP; Chromatography instrumentation and supplies.

Main products/instrumentation under R&D: Biopharmaceuticals, ethical pharmaceutical.

749 CIBLEX CORPORATION 747 CHRYSALIS BIOTECHNOLOGY Add: 2200 Market, Ste. 600 Galveston, TX 77550 Tel: (409) 750-9251 Fax: (409) 750-9253 Web site: www.chrysalisbio.com President: Darrell H. Carney R&D expertise: Tissue repair research, products development and manufacture. R&D collaboration: OrthoLogic (OLGC), bone fracture healing. Key sales market contracts: OLGC for U.S. bone fracture; Abbott Labs for wound healing. Technological expertise: Z, TE, DD, D-D, P/S, C/TC, SMC, SY, PIS Main products/instrumentation under R&D: Chrysalin for chronic wound healing, Phase II/III.

748 CHUGAI BIOPHARMACEUTICALS, INC. Add: 6275 Nancy Ridge Drive San Diego, CA 92121

Add: 11025 Roselle St., Suite 200 San Diego, CA 92121 Tel: (619) 546-7848 Fax: (619) 546-7896 Web site: www.ciblex.com President/CEO: Gary Hooper Research director: Andrew Baird, Ph.D. R&D expertise: Research and development of therapeutical drugs for cancer, inflammatory disease, infectious disease, other diseases, related novel products manufacture. Technological expertise: Q, C/TC, HTDS, RD Main products/instrumentation under R&D: CBX10913 for treatment for cancer, preclinical; CBX12266, for treatment of inflammatory disease, preclinical; CBX18469 for inflammation, preclinical; CBX17653 for treatment of cancer and inflammatory disease, preclinical.

750 CID TECHNOLOGIES, INC. Add: 101 Commerce Blvd. Liverpool, NY 13088 Tel: (315) 451-9410

Tel: (858) 535-5900

Fax: (315) 451-9421

Fax: (858) 453-9066

E-mail: [email protected]

E-mail: [email protected]

Web site: www.cidtec.com

Web site: www.chugaibio.com

Research director: Joe Carbone

President/CEO: Henry L. Nordhoff

Subsidiary of Thermo Vision

Subsidiary of Chugai Pharmaceuticals

R&D expertise: Development and manufacture of CID (Charge Injection Device) cameras.

R&D expertise: Research and development of ethical pharmaceuticals.

Technological expertise: BME

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Joint ventures: Thermo Jarrell Ash — ICP’s, POEMS, Rochester Institute of Technology; U.S. Army Forensics, DNA sequencing. R&D collaboration: TJA, PIT, Infimed. Key sales market contracts: TJA, Infimed. Key license and trade contracts: TJA, Infimed. Principal products/instrumentation: Biosensors, contract manufacturing products, contract research/clinical trial products, food processing, human genome project, all CID (Charge Injection Device) sensors and cameras. Radiation hardened, intensified, random addressable Anti-Blooming. Main products/instrumentation under R&D: Dental X-Ray imager, Random addressable 1024 x 1024 sensor (CMOS) type. Sealed and granted patents: Charge Injection Device, Pre-amp per pixel, Noise loopback subtraction.

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Main products/instrumentation under R&D: Wound healing, preclinical; adjuvant, preclinical; inhibitors of IL-IB, preclinical, other human cytokine. Sealed and granted patents: 4,762,914; 4,766,069; 5,001,057, 5,007,219; 5,474,899 and 5,510,462; 5,122,459; 5,484,887; 5,789,185.

752 CIVILIZED SOFTWARE, INC. Add: 12109 Heritage Park Circle Silver Spring, MD 20906 Tel: (301) 962-3711; (301) 652-4714 Fax: (301) 962-3712 E-mail: [email protected] Web site: www.civilized.com President/CEO: Gary D. Knott Research director: Gary D. Knott

Add: 10 Bloomfield Ave. Box 2004 Pine Brook, NJ 07058

R&D expertise: Research and development of advanced mathematical and statistical software ideal for ligand-binding ultra centrifuge, kinetic analysis, compartmental modeling, neurophysiology, drug combination analysis.

Tel: (973) 575-1700

Technological expertise: CH/S

Fax: (973) 575-4854

Principal products/instrumentation: MLABadvanced mathematical and statistical analysis and modeling software. One example of the applications is drug combination analyzer.

751 CISTRON BIOTECHNOLOGY, INC.

E-mail: [email protected] Web site: www.cistronbio.com President/CEO: Bruce Galton R&D expertise: Research and manufacture of human cytokines. Technological expertise: F, PA, Q, RD, C/TC, DD, H/CF, P/S, RD Principal products/instrumentation: Recombinant precursor human IL-LB; recombinant human mature IL-lb; recombinant human mature IL-la; anti-human IL-lb monoclonal antibody; anti-human IL-lb polyclonal antiserum; human IL-lb and IL-6 ELISA kits; human IL-1b precursor polyclonal antibody; anti-human PAI-2 polyclonal antibody.

753 CLAR Add: Domaine de Radinghem Radinghem 62310 France Tel: (33) 21-41-4062 Fax: (33) 21-03-7419 President: Bernard Quinque Research director: Olivier Canivez R&D expertise: Research and development of agro-food, cosmetics, medicine, biotechnology,

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products extracted from colostrums, related novel products manufacture.

Technological expertise: PA, F, C/TC, LP, PMC, P/S, H/CF

R&D collaboration: INRA, Universities

Principal products/instrumentation: Biologicals, contract manufacturing products, monoclonal antibodies.

Technological expertise: E, P/S Principal products/instrumentation: Cosmetics, all biomolecules extracted from bovine colostrum, vaccines, reagents, antibodies.

754 CLARAGEN, INC. Add: 335 Paint Branch Dr. College Park, MD 20742 Tel: (301) 405-8593 Fax: (301) 405-4989 President/CEO: Mark F. Zirtumer Research director: Aprile L. Pilon, Ph.D.

Main products/instrumentation under R&D: Safety testing method of biopharmaceuticals.

756 CLB, R&D DIVLSION Add: Plesmanlaan 125 Amsterdam NL-1066 CX Netherlands Tel: (31) 20-512-3168 Fax: (31) 20-617-0981 E-mail: [email protected] Web site: www.clb.nl CEO: Prof. E.J. Ruitenberg

R&D expertise: Biopharmaceutical development, related novel products manufacture.

Research director: R.F. Tiebout, M.D.

R&D collaboration: NIH Crada.

R&D expertise: Contract research and contract manufacture of biotechnology medicines.

Key license and trade contracts: NIH. Technological expertise: F, P/S, BA, DD Main products/instrumentation under R&D: Anti-inflammatory disease, anti-fibrotic biopharmaceuticals, in preclinical development.

755 CLB BIOTECHNOLOGY DEPARTMENT

Technological expertise: PA, BS, C/TC, GT, H/CF Main products/instrumentation under R&D: Biologicals, contract manufacturing products, contract research/clinical trials products, in vitro toxicology testing method, other biotechnology medicines.

757 CLEAN AIR TECHNOLOGY, INC.

Add: Plesmanlaan 125 Amsterdam 1066 CX Netherlands

Add: 41105 Capital Canton, MI 48187

Tel: (31) 20-512-3549

Tel: (734) 459-6320

Fax: (31) 20-512-3550

Fax: (734) 459-9437

E-mail: [email protected]

E-mail: [email protected]

President: P. C. Van Mourik

Web site: www.cleanairtechnology.com

Research director: B. J. M. Al

President/CEO: Frank X. Austin

R&D expertise: Contract production of biologicals; safety testing method of biopharmaceuticals.

R&D expertise: Development and manufacture of modular clean rooms. Technological expertise: BME.

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Principal products/instrumentation: Class 10 to 100,000 clean rooms; Whisperquiest Recirculating Air; Handers, Aseptic Fill and containment Module.

Fax: (203) 421-4500

Sealed and granted patents: Modular clean room structure. #5,029,518; Washable seamless clean room. #5,256,105.

Research director: Michael Morris

758 CLEAR SOLUTIONS BIOTECH, INC. Add: 50 East Loop Rd. Stony Brook, NY 11790 Tel: (516) 689-9036 Fax: (516) 689-2890 President: Dr. James Hayward

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E-mail: [email protected] President/CEO: Henry Clemente Subsidiary of Clemente Associates, Inc. R&D expertise: Development and manufacture of magnetic particles/separators for diagnostic, research, clinical markets, and molecular biology reagents. Technological expertise: C, G, PI, P/S, C/TC Principal products/instrumentation: Magnetic particles; Nucleic acids, magnetic particles separators for diagnostics. Subsidiary bodies: Milford, CT; Barnsville, MD.

Research director: Dr. Philip Dehazya R&D expertise: Development and manufacture of Hyaluronic acid derivatives for tissue engineering, wound healing, ophthalmic anticancer indications, drug delivery applications; Contract R&D and manufacturing.

760 CLINFORCE, INC. Add: 4815 Emperor Blvd., Ste. 300 Durham, NC 27703 Tel: 800-964-2877

Key license and trade contracts: Lab Sophia, Mexico — HA for ophthalmic indications.

Fax: (919) 941-0071

Technological expertise: E, F, TE, CB, C/TC, DD, P/S, SY

Web site: www.clinforce.com

Main products/instrumentation under R&D: Organ transplants/culture, HA-based Ophthalmic drugs, preclinical; Wound, skin, tissue engineering products, preclinical; HA-based anti-inflammatory drugs, preclinical; HAbased cytotoxic drugs, preclinical; hyaluronic acid derivatives for wound healing. Sealed and granted patents: U.S. #5,652,347; U.S. #5,616,568; U.S. #5,874,417; Gene encoding hyaluronan synthase. 6,602,693, U.S.

759 CLEMENTE ASSOCIATES, INC. Add: 33 Harkness Dr. Madison, CT 06443 Tel: (203) 421-4500

E-mail: [email protected] CEO: Tony Sims, EVP R&D expertise: Contract clinical personnel and direct recruiting services for the pharmaceutical and biotech industries. Main products/instrumentation under R&D: Contract research/clinical trials products, pharmaceuticals, vaccines, reagents, antibodies. Subsidiary bodies: 7 Headquarters Plaza Morris-town, NJ 07960-3976 Tel: (877) 254-6367; Commonwealth Financial Center 12730 New Brittany Blvd. Ste 412, Ft Myers, FL 33907 Tel: (941) 931-6000; Highland March Executive Suites 140 Wood Road Ste 200, Braintree, MA Tel: (877) 776-6002; P.O. Box 15835 Cincinnati, OH 45215.

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761 CLINILAB

763 CLINTRIALS BIORESEARCH, LTD.

Add: 4, 160 St., El-Etehad Square, Riham Tower, El-Maadi Cairo P.O. Box 12 El-Manial Egypt

Add: 87 Senneville Rd. Senneville, Quebec H9X 3R3 Canada

Tel: (20) 2-525-7212

Fax: (514) 630-8230

Fax: (20) 2-525-7210

E-mail: [email protected]

E-mail: [email protected]

President/CEO: Michael F. Ankcorn

President/CEO: Dr. Nibal Mohammed Fahmy

Research director: George Lulham

R&D expertise: Import and export of pharmaceutical products.

R&D expertise: Contract research organization of preclinical laboratory drug research and development.

Technological expertise: P, Q, TE, T, SY, R, RD, C/TC, GA, GT, P/S Principal products/instrumentation: Agriculture, biologicals, chemicals, clinical tests, human genome project, instrumentation, in vitro toxicology testing, organ transplants/culture, pharmaceuticals, plastics, reagents, vaccines, veterinary drugs, vaccines, antibodies.

762 CLINPRO INTERNATIONAL CO. LLC.

Tel: (514) 630-8200

Subsidiary of ClinTrials Research Inc.

Technological expertise: CC, GT, DD, AF, AB, BS, CB, C/TC Principal products/instrumentation: Contract research/clinical trial products, in vitro toxicology testing products. Subsidiary bodies: Institute Armand Frappier (BSL2/3 facilities); exclusive agreement.

764 CLINTRIALS RESEARCH Add: 11000 Weston Parkway Gary, NC 27513

Add: 4825 Gina Way Union City, CA 94587

Tel: (919) 460-9005

Tel: (510) 489-6093

Fax: (919) 462-2520

Fax: (510) 489-5630 E-mail: [email protected]

E-mail: clientdevelopment@clintrialsresearch. com

Web site: www.clinpro.simplenet.com

Web site: www.clintrialsresearch.com

President: Fred Pearlman

President: Dr. Graham May (North America)

R&D expertise: International import and export of diagnostic drug products, ELISA tests and rapid tests, clinical consulting services.

Research director: Byron Mchees (Chief Medical Officer)

Technological expertise: E

Principal products/instrumentation: Contract research/clinical trial products.

Principal products/instrumentation: Tumor Markers ELISA; Infectious Disease ELISA and Rapid Test; Endocrine Hormone ELISA; Autoimmune Tests.

R&D expertise: Contract research for pharmaceutical development and manufacture.

Subsidiary bodies: BRUSSELS, BELGIUM ClinTrials Research, Inc. Tel: (32) 2-714-5050; MAIDENHEAD, UK ClinTrials Research

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Tel: (44) 16-28-789-999; MELBOURNE, AUSTRALIA ClinTrials Research Pty. Ltd Tel: (61) 3-9827-0422; TEL AVIV, ISRAEL ClinTrials Research Israel Ltd. Tel: (972) 3904-8161; MONTREAL, CANADA ClinTrials BioReseach Tel: (514) 630-8200; PARIS, FRANCE ClinTrials Research SARI Tel: (33) 1-53-24-9400; WARSAW, POLAND ClinTrials Research Sp.z.o.o. Tel: (48) 22-833-8374; MILAN, ITALY ClinTrials Research, Inc. Tel: (39) 02-67-843-201; GLASGOW SCOTLAND ClinTrials Research, Inc. Tel: (44) 141222-5500; MADRID, SPAIN ClinTrials Research S.L. Tel: (34) 91-426-3876.

765 CLONETICS CORP. Add: 8830 Biggs Ford Rd. Walkersville, MD 21793-8415 Tel: (800) 852-5663; (800) 344-6618 Fax: (619) 541-0823 E-mail: [email protected] Web site: www.clonetics.com President/CEO: Noel Buterbaugh Research director: Sov Kanmiol R&D expertise: Research and novel drugs development of normal human cell systems, serum-free medium, in vitro bioassays, cell systems, related novel products manufacture. R&D collaboration: University of Colorado. Technological expertise: C/TC Principal products/instrumentation: Normal human cells: aortic cell, pulmonary and umbilical endothelial cell, aortic and pulmonary smooth muscle cell, keratinocytes, melanocytes, fibroblasts, bronchial/tracheal epithelial cell, skeletal muscle cells, mammary epithelial cells; optimized media; serum-free medium cytotoxicity bioassays; microvascular endothelial cells, bronchial/tracheal cell system; coronary artery cells, renal proximal tubule

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epithelial cells, small airway epithelial cells; Hepatocytes.

766 CLONEX CORPORATION Add: 169 Idema Rd. Markham, ON L3R 1A9 Canada Tel: (905) 940-3885 Fax: (905) 940-1832 E-mail: [email protected] President: George Guluzian Research director: Bemie Hazar R&D expertise: Development and manufacture of laboratory apparatus for biotechnology laboratory. Joint ventures: InterScience Inc., Labnet. R&D collaboration: Cos Acrylics. Key sales market contracts: InterScience Inc. Technological expertise: P/S Principal products/instrumentation: Contract manufacturing products, contract research/clinical trial products, pharmaceuticals ClonePette, Gelclone, Safe-Lab. Main products/instrumentation under R&D: Laboratory apparatus for biotechnology laboratory.

767 CLONEXPRESS, INC. Add: 504 East Diamond Ave., Suite G. Gaithersburg, MD 20877 Tel: (301) 869-0840 Fax: (301) 963-4214 E-mail: [email protected] President/CEO: T. Venkat Gopal, Ph.D. R&D expertise: Research and development of gene therapy, cell therapy, in vitro toxicology, drug metabolism; related novel products manufacture.

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Joint ventures: Technology Management & Funding, L.P.

769 CLONTECH LABORATORIES, INC.

Technological expertise: RD, TE, BS, C/TC, GT, H/CF

Add: 1020 East Meadow Circle Palo Alto, CA 94303-4230

Principal products/instrumentation: Organ transplants/culture, reagents, clinical tests, contract research/clinical trials products, dendritic cells, macrophage.

Tel: (415) 424-8222; (800) 662-CLON

Main products/instrumentation under R&D: In vitro draize test; In vitro toxicology and drug metabolism, cell therapy, gene therapy, bone marrow toxicity testing.

768 CLONTECH LABORATORFIES GMBH Add: Tullastrasse 4 Heidelberg 69126 Germany Tel: (49) 62-213-4170 Fax: (49) 62-213-03511 E-mail: [email protected] Web site: www.clontech-gmbh.com President: Dr. Michael Ehret Research director: Dr. Juergen Gamer Subsidiary of CLONETECH Laboratories, Inc. R&D expertise: Development and manufacture of kits and reagents for molecular biology research. Principal products/instrumentation: Biosensors, contract manufacturing products, contract research/clinical products, reagents, cDNA Expression Arrays; PCR Systems; Multiple Tissue Northern Blots; GFP Vectors.

Fax: (415) 424-1352 E-mail: [email protected] President: Kenneth Fong, Ph.D. Research director: Paul Siebert, Ph.D. R&D expertise: Research and development of biotechnology medicines diagnostic products manufacture. Key license and trade contracts: Stanford, Harvard, Roche, Baylor, BASF. Technological expertise: Q, E, RD, P/S, GA, SY, AB, CH/S Principal products/instrumentation: Contract research/clinical trials products cDNA libraries; PCR-based systems and primers; mutagenesis kit for double-stranded DNA; MTN blots; genome project products; cloning and expression vectors; proteins and peptides; quick-clone cDNAs, GFP. Main products/instrumentation under R&D: PCR-based diagnostics; other biotechnology medicines. Related and granted patents: Recombinasebased methods for producing expression vectors and compositions for use in practicing the same, 6,410,317, U.S.; polymeric arrays and methods for use in binding assays, 6,489,159, U.S.

770 C.M.I. LTD.

Main products/instrumentation under R&D: GFP Assays, suppression PCR novel kits and reagents for molecular biology research.

Add: United House 113 High Street, Collingham Newark, Notts NG23 7NG UK

Sealed and granted patents: Suppression PCR.

Fax: (44) 0163-689-3037

Tel: (44) 0163-689-2078 President: C. D. Muirhead

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Research director: H. J. Dickinson R&D expertise: Agricultural products Principal products/instrumentation: Agriculture, contract manufacturing products, natural products, pesticides, cypermethrin Technical, CM Cypermethrin (CYMBAZ); Permethrin Technical, CM Permethrin (PELBAZ); 6% FE EDDHA, Super-Fer; 21% Soluble Boron, Super-flor Boron.

771 CMI, LTD. Add: United House 113 High Street, Collingham Newark, Notts UK Tel: (44) 0163-689-2078 Fax: (44) 0163-689-3037 President: G. D. Muirhead Research director: H. J. Dickinson R&D expertise: Development and manufacture of agricultural products. Technological expertise: CS, OC Principal products/instrumentation: Agriculture, contract manufacturing products, natural products, CM Cypermethrin (CimBaz); Permethrin Technical, CM Permethrin (Pelbaz); 6% FE Eddha, Super-EER; 21% soluble Boron, ‘Superflor’ Boron, pest control chemical.

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R&D expertise: Peptide and peptide instrumentation, Calbiochem, Novabiochem, Oncogene Research Products and Novagen subsidiary brands. R&D collaboration: University of Nottingham. Key license and trade contracts: Novatis, Hoechst Marion Roussel, Affymax, Warnerambert. Technological expertise: CS, PA, PIS, RD, AB, H/CF, P/S, SY, CB, COC, C/TC Principal products/instrumentation: Produce peptides: PYbop, Pybrop, Dde-OH, Dmab-OH, Fmoc-Lys (Dde)-OH, Fmoc-Lys (inDde)-OH, Amino acid-2-clorotrityl resins, FmocAmino acids, Fmoc-Amino acid wang resins, HOBt-Polystyrene, Carbodimide-polystyrene, Somatostatin, Piperidine-polystyrene, Rink Amide resin, Merrifield resin. Over 100 new products for combinational chemistry, scavenger resins, immobilized reagents, multifunctional building blocks, photo-cleavable resins, formyl-PS, Methylthiourea-PS, Vinylsulfomethyl-PS. 9,000 biologicals and bioreagents for study of disease-related life science research. Subsidiary bodies: Calbiochem-Novabiochem AG, Laufelfingen, Switzerland; Oncogene Research Products, Cambridge, MA, USA.

773 CN BIOSCIENCES UK 772 CN BIOSCIENCES, INC.

Add: Blvd. Industrial Park Padge Rd. Beeston, Nottingham NG9 2JR UK

Add: 10394 Pacific Center Ct, San Diego, CA 92121

Tel: (44) 0115-943-0840

Tel: (619) 450-9600; (800) 228-9622

E-mail: [email protected]

Fax: (619) 453-3552; (800) 432-9622

Web site: www.cnuk.co.uk

E-mail: [email protected]; [email protected]

President: Susan D. Sinclair

Web site: www.cnbi.com; www.nova.cn

Research director: Peter White, Ph.D.

President: James Stewart

R&D expertise: Research of biochemicals, peptide and peptides instrumentation.

Research director: John Snow, Ph.D.

Fax: (44) 0115-943-0951

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Key sales market contracts: Calbiochem, Novabiochem, Oncogene Research Products and Novagen. Technological expertise: C, CC, E, PIS, PA, RD, P/S, COC, C/TC Principal products/instrumentation: Peptide synthesizer; peptide sequencer; peptide synthesis resins and amino acid derivatives, signal transduction, apoptosis, glycobiology, immunology and oncogene research products; dinalfa bioactive compounds; biochemicals; Elisa kits; nitric oxide; complements, molecular biology, protein purification and expression products, competent cells; endothelins, bradykinin, neuropeptide Y, substance P, custom synthesis products. Main products/instrumentation under R&D: Novabiochem range of resins and reagents for combinatorial chemistry, solid phase organic chemistry and peptide synthesis, solid supported reagents. Subsidiary bodies: European Distribution Centre.

775 COCALICO BIOLOGICALS, INC. Add: 449 Stevens Rd. P.O. Box 265 Reamstown, PA 17567 Tel: (717) 336-1990 Fax: (717) 336-1993 E-mail: [email protected] Web site: www.cocalicobiologicals.com CEO: Jean Whitesel R&D expertise: Production and development of animal sera, plasmas, red blood cells and custom preparation of polyclonal and monoclonal antibodies. Technological expertise: PA, P/S, H/CF, C/TC Principal products/instrumentation: Custom polyclonal and monoclonal antibodies. Main products/instrumentation under R&D: Red blood cell, animal sera, animal cell culture.

776 COCENSYS, INC. Add: 201 Technology Dr. Irvine, CA 92618

774 COAST SCIENTIFIC, INC.

Tel: (949) 753-6100 Fax: (949) 753-6161

Add: 7077 Consolidated Way, Suite G. San Diego, CA 92121 Tel: (858) 635-6622; (800) 445-1544 Fax: (858) 635-6699; (800) 791-8999 E-mail: [email protected] Web site: www.coastscientific.com President: Tony Shahri R&D expertise: Development of custom peptide synthesis, peptide instrumentation, laboratory, industrial safety and clean room applied products.

E-mail: [email protected] Web site: www.cocensys.com President/CEO: F. Richard Nichol, Ph.D. R&D expertise: Research of pharmaceutical therapies for CNS disorders, related novel products manufacture. R&D collaboration: Warner-Lambert, WyethAyerst. Technological expertise: SMC, D-D

Technological expertise: PA, RD, AB, P/S, PIS

Principal products/instrumentation: Ganaxolone — anti-convulsant and anti-migraine (CCD-1042); licostinel — anti-stroke drug.

Principal products/instrumentation: Full line of apparel, gloves, pipe tips, tubes, plastic and glassware, peptide synthesis products, peptide arrays, peptide chains, peptide synthesizer.

Main products/instrumentation under R&D: Anti-stroke novel drug, Phase II; anti-convulsant, Phase II/III; anxiolytic, preclinical; sedative hypnotic, clinical; anti-migraine, Phase III;

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SSNRAs for treatment of Parkinson’s disease, research; AMPA Antagonists for neurodegenerative disorders, research; Sodium channel blocker for neuropathic pain, preclinical; other therapeutics for CNS disorders.

777 COGENT DIAGNOSTICS, LTD. Add: Douglas House Pentlands Science Park Bush Loan, Edinburgh EH26 0PL UK Tel: (44) 131-448-2121

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Main products/instrumentation under R&D: CNS, PNS, and cardiovascular drugs. Therapeutics categories include epilepsy, neuroprotectic Alzheimer’s disease, pain, Parkinson’s disease, arrhythmia, cancer, spinal injury, schizophrenia. Subsidiary bodies: Cognetix, Inc., 421 Wakara Way, Salt Lake City, UT 84108. Sealed and granted patents: Eight patents held on compositon of matter and therapeutic use of peptides derived from marine cone snails; Conotoxin peptides, 6,767,896, U.S.

Fax: (44) 131-448-2122 President: Charles Fairley, Ph.D. Research director: Jim Weston, Ph.D.

779 COHESIVE TECHNOLOGIES, INC.

R&D expertise: Development, manufacture of immunodiagnostic kits and reagents.

Add: 101 Constitution Blvd. Franklin, MA 02038

Technological expertise: P/S, BA, C/TC

Tel: (800) 246-4550

Principal products/instrumentation: Reagents, Autostat II autoimmune diagnostics.

Fax: (508) 528-8699

Main products/instrumentation under R&D: Range extension for Autostat, clinical phase; doctors’ office tests.

E-mail: [email protected] Web site: www.cohesivetech.com President/CEO: Hubert M. Quinn Research director: Daniel Mageira, Ph.D.

778 COGNETIX, INC. Add: 421 Wakara Way, Suite 201 Salt Lake City, UT 84108 Tel: (801) 581-0400 Fax: (801) 581-9555 E-mail: [email protected] President: Dennis B. Farrar Research director: R. Tyler McCabe, Ph.D. R&D expertise: Drug discovery, design, screening and development of CNS, PNS, and cardiovascular therapeutics using combinatorial and small molecule organic chemistry on compounds derived from marine predatory conus snails. R&D collaboration: Sibia Neurosciences, Inc. Technological expertise: COC, DD, D-D, SMC, SY

R&D expertise: Peptides and peptide instrumentation research; biopurification technologies development. Technological expertise: P/S, P/P, BA, BP Principal products/instrumentation: Separation and purification columns, media, patented peptide instruments. Turbolink 2,200 chromatography system for methods development and purification, purification and separation columns in ion-exchange, hydrophobic interaction. Main products/instrumentation under R&D: Columns for biopurification.

780 COLDER PRODUCTS CO. Add: 1001 Westgate. Dr. Saint Paul, MN 55114-1630

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Tel: (612) 645-0091 Fax: (612) 645-5404 E-mail: [email protected] Web site: www.colder.com President: Michael D. Lyon

plastic ware, PH meters, tissue culture products, liquid handling, centrifuges, microbial analysis, fermentation, autoclaves, balances, baths and circulators, specialty chemicals, incubators, glove boxes, shakers, tubing; Masterflex Pumps; Masterflex Tubing.

Research director: Brian J. Blenkush R&D expertise: Development and manufacture of quick disconnect couplings for lowpressure fluid management applications. Technological expertise: C/TC, BA Principal products/instrumentation: MPC series coupling; MPX series coupling; HFC series coupling, biologicals, biomaterials, cosmetics, detergents, diagnostics, in vitro toxicology testing, reagents, toxic waste processing, vaccines, veterinary drugs. Main products/instrumentation under R&D: Quick disconnect couplings for low-pressure fluid management.

782 COLIBRI ROBOTICS, INC. Add: 11A Parkway Circle New Castle, DE 19720 Tel: (302) 326-0433 Fax: (302) 326-0492 E-mail: [email protected] Web site: www.colibrirobotics.com President/CEO: Lee Carter Research director: Rich Hughes

Subsidiary bodies: Colder Products Co., GmbH -Gross-Gerau Germany.

R&D expertise: Drug discovery research, laboratory robotics development, related novel products manufacture.

Sealed and granted patents: Over 20 patents for quick disconnect couplings.

Joint ventures: Qiagen, Olympus, Packard, Immunol; Digene.

781 COLE-PARMER INSTRUMENT CO. Add: 625 East Bunker Court Vernon Hills, IL 60061 Tel: (847) 549-7600 Fax: (847) 247-2929 E-mail: [email protected] Web site: www.coleparmer.com R&D expertise: Development of biomedical laboratory professional equipment for drug research. Technological expertise: F, P/S, C/TC Principal products/instrumentation: Electrophoresis apparatus, ultraviolet equipment, HPLC, preparative columns, water purification, masterflex pumps, filtration, chromatography,

R&D collaboration: Qiagen, Olympus, Packard, Immunor, Digene. Key sales market contracts: Qiagen, Olympus, Packard, Immunor, Digene. Key license and trade contracts: Qiagen, Olympus, Packard, Immunor, Digene. Technological expertise: Q, COC, DD, D-D, GA, HTDS, P/S, R, PIS, H/CF, G Principal products/instrumentation: Liquid Handling Plate; MTP reader and washer luminometer. Main products/instrumentation under R&D: Robotics, cell lines using cell based assays, immuno assays; screening systems using solid phase extraction, resin/powder dispensing, high throughput screening, DNA purification, DNA amplification, plate replicating and sample splitting.

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783 COLLABORATIVE BIOALLIANCE Add: 50 East Loop Rd. Stony Brook, NY 11790 Tel: (516) 689-9036 Fax: (516) 689-6880 E-mail: [email protected] Web site: www.the-cba.com President/CEO: Dr. James A. Hayward Research director: Dr. Vish Rai Subsidiary of Collaborative Group Ltd. R&D expertise: Development and manufacture of contract manufacturing products, CGMP microbial fermentation research and liposome manufacture.

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Main products/instrumentation under R&D: Contract manufacturing products, Hyaluronic acid derivatives and hydrogels, encapsulated drugs. Subsidiary bodies: Long Island High Technology Incubator, Stony Brook, NY, USA; Manufacturing and Warehousing, East Setauket, NY, USA. Sealed and granted patents: Liposome area: 0,319,638 Europe; 4,675,310 USA; 4,319,638 USA; 4,999,348 USA; 01,586 UK; 01,587 UK; 04,326 UK; GB 847,557 UK; GB 8,522,964 UK.

785 COLLGARD BIOPHARMACEUTICALS, INC.

R&D collaboration: State University of New York, Stony Brook.

Add: 1860 Beacon St. Waban, MA 024681442

Technological expertise: F, BA, DD, D-D

Tel: (617) 244-6016

Main products/instrumentation under R&D: Biologicals, contract manufacturing products, liposome, catezomes.

Fax: (617) 244-6026

Sealed and granted patents: Catezomes.

E-mail: [email protected] Web site: www.collgard.com President/CEO: Neal M. Farber, Ph.D. Research director: Shari Yarkoni. M.D.

784 COLLABORATIVE GROUP, INC. Add: 3 Technology Dr. East Setauket, NY 11733-4072

Subsidiary of Collgard Biopharmaceuticals, Ltd.

Fax: (516) 689-6880

R&D expertise: Drug development and manufacture for treatment of cancer, restenosis, fibrosis, scleroderma; other drug and pharmaceuticals development.

E-mail: [email protected]

Technological expertise: SMC, SY

Web site: www.collabo.com

Main products/instrumentation under R&D: Halofuginone, Phase III.

Tel: (516) 689-0200

President/CEO: James A. Hayward, Ph.D. Research director: David Watkins, D.Phil. R&D expertise: Development of drug encapsulation and controlled delivery technologies; contract biologicals manufacturing; other contract R&D and manufacturing. Technological expertise: GT, P/S, SY, F, BA, CB, C/TC, DD

Subsidiary bodies: Collgard Biopharmaceuticals, Ltd., 2 Kaufaman St., Tel Aviv 68012, Israel, Tel: (972) 3-516-0577; Fax: (972) 3-516-0576.

786 COLORADO SERUM CO. Add: 4950 York St. Denver, CO 80216

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Tel: (303) 295-7527

Research director: David Carney

and matching software; BatchMaster — process manufacturing software; ColorTec — PCM color instrument; ColorTec — color instrument; ColorTec-TRS, transmission color instruments.

R&D expertise: Development and manufacture of veterinary biologicals and diagnostic reagents.

Main products/instrumentation under R&D: SQL Server Systems, software for batch process control.

Fax: (303) 295-1923 President: Joseph N. Huff

Joint ventures: Bayer, Schering Plough Technological expertise: F, PA, P/S, C/TC, CH/S

788 COLUMBUS INSTRUMENTS

Principal products/instrumentation: RB 51, animal health products, animal blood and sera, veterinary vaccines.

Add: 950 N. Hague Ave. Columbus, OH 43204

Main products/instrumentation under R&D: Diagnostic reagents.

Fax: (614) 276-0529

Tel: (614) 276-0861 E-mail: [email protected] Web site: www.colinst.com

787 COLOR-TEC Add: 28 Center St. Clinton, NJ 08809

R&D expertise: Development and manufacture of biotech lab equipment and bioprocess engineering products.

Tel: (908) 735-2248

Technological expertise: F, PMC

Fax: (908) 236-7865

Principal products/instrumentation: O2/CO2 Respirometer; Fermentation Gas Sensor.

E-mail: [email protected] Web site: www.color-tec.com President: James T. DeGroff

Main products/instrumentation under R&D: Biotech lab equipment, biotech labwares.

Research director: Carolyn Worrier R&D expertise: Research and development of software for batch process control, business, color technology, related novel products manufacture. Joint ventures: Batch master software; Foots MFG Group. R&D collaboration: Color instruments and software.

789 COMBINIX Add: 1039 S. Claremont St. San Mateo, CA 94402 Tel: (650) 577-0718 Fax: (650) 577-0719 E-mail: [email protected]

Key sales market contracts: Color instruments.

Web site: www.combinix.com

Key license and trade contracts: Color software for Windows Platform.

President: Nicholas Cairns

Technological expertise: CH/S

R&D expertise: Research and production of synthetic organic chemistry.

Principal products/instrumentation: Contract manufacturing products, colorSoft — color QC

Technological expertise: CC, COC, D-D, PIS, P/S, SMC, SY

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Products under R&D: Contract research/ clinical trials products, reagents, vaccines, antibodies. Main products/instrumentation under R&D: Synthetic organic chemistry.

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Technological expertise: BME Principal products/instrumentation: Reconditioned equipment, Life-Cycle Management Services.

792 COMERCIAL WAFER S.L. 790 COMBITECH LIMITED Add: Bolonia 12 Zaragoza 50008 Spain Add: 8 James Whatman Court Turkey Mill, Ashford Road Maidstone, Kent MEW 5SS UK Tel: (44) 162-266-2118 Fax: (44) 162-266-4157 E-mail: [email protected] President: Ian Causton R&D expertise: Provide products and research services for drug discovery, drug design and drug development. Key sales market contracts: Robocon, CYBIO Instruments. Technological expertise: BI, CH/S, DD, DDI, D-D, HTDS, R

Tel: (34) 97-623-7400 Fax: (34) 97-621-7152 E-mail: [email protected] President: Nicolas Ramos R&D expertise: Development and manufacture of scientific/analytical instrumentation. General supplies and diagnostic material for laboratories. Technological expertise: PA, Q, C/TC, GA, P/S, RD Main products/instrumentation under R&D: Analytical instruments, organ transplants/culture products, drug separation devices.

Principal products/instrumentation: ROBOLAB automated laboratory; JOBI-Well. Main products/instrumentation under R&D: Drug screening devices.

793 COMGENEX, INC. Add: Bem Rkp 33-34 Budapest H-1388 Hungary Tel: (36) 1-214-2306

791 COMDISCO HEALTHCARE AND SCIENTIFIC GROUP Add: 50 Shawmut Rd. Canton, MA 02021 Tel: (781) 535-0777 Fax: (781) 575-0084 E-mail: [email protected] Web site: www.comdisco.com President/CEO: Frank Cirone Subsidiary of Comdisco, Inc. R&D expertise: Development, manufacture, re-marketing and reconditioning of biomedical equipment for drug research.

Fax: (36) 1-214-2310 E-mail: [email protected] Web site: www.comgenex.hu; www.comgene direct.hu President/CEO: Ferenc Darvas, Ph.D. Research director: Gyorgy Dorman, Ph.D. R&D expertise: Research in drug discovery of biopharmaceuticals/pharmaceuticals and related novel product development/manufacture. Technological expertise: DDI, DD, D-D, C/TC, BI, BTS, CH/S, COC, HTDS, SSMSA Main products/instrumentation under R&D: Combinatorial libraries, synthesis platforms,

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HT analytical systems, etc., therapeutic diseases focused on: anti-cancer, pesticides, anti-HIV, herbicides, anti-hypertensive, anti-inflammatory diseases. Products compound classes are drug-like heterocyclic small molecules. The used cell lines are NA. The used Screening systems are In silico ADME Screening, hepatacytes for in vitro metabolic profiling, HTS LC/MS. Drug discovery is under Hungarian State Department of Research and Development grant.

794 COMGENEX INTERNATIONAL Add: 705 Grand-view Dr. South San Francisco, CA 94080

Web site: www.cbi-biotech.com President: Dr. Robert B. Harris Research director: Dr. Richard J. Freer R&D expertise: Development and manufacture of R&D support for life sciences including DNA and protein sequence analysis, DNA/RNA and peptide synthesis, immunochemistry, genetic identity testing, calorimetry, mass spectroscopy, genomics, molecular biology. Technological expertise: Q, E, D-D, GA, PIS, BI, COC, PA, G, RD, P/S, H/CF, C/TC, CH/S, SY, AB Principal products/instrumentation: AccuTrac — lane marker for DNA sequencing gels.

President: Ferenc Darvds, Ph.D.

Main products/instrumentation under R&D: Defined heparins (animal trials); heparin antagonists (development); targeted ribozymes (development); DNA sequencing technologies (development); chip technology (development); forensic and genetic testing (development).

R&D expertise: Development and manufacture of small molecule compounds.

Sealed and granted patents: HepArrest (heparin antagonist).

Tel: (650) 246-1470 Fax: (650) 244-0795 E-mail: [email protected] Web site: www.comgenex.com

Technological expertise: COC, D-D, HTDS, R, SMC, SY Principal products/instrumentation: Small molecule compound libraries; designed molecular diversity; high throughput organic synthesis; custom library synthesis. Main products/instrumentation under R&D: Small molecule organic compound.

796 COM: ONE DEVICES, INC. Add: 1526 Elka Avenue San Jose, CA 95129 Tel: (408) 725-1023 Web site: www.com-one.com President: Marty Wolf R&D expertise: Development and manufacture of computer-aided devices.

795 COMMONWEALTH BIOTECHNOLOGIES, INC. Add: 601 Biotech Dr. Richmond, VA 23235 Tel: (800) 735-9224 Fax: (804) 648-2641 E-mail: [email protected]

Technological expertise: C/TC, BME Principal products/instrumentation: Instrumentation, Cytogenic liquid level controllers and monitoring devices, cytogenic refrigerators, nitrogen, oxygen, argon. Main products/instrumentation under R&D: Computer-aided devices.

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797 COMPLETE FILTRATION RESOURCES Add: 160 83rd. Ave., N.E. Minneapolis, MN 55432 Tel: (612) 784-0111 Fax: (612) 784-3200 E-mail: [email protected] President: Don Benson

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Principal products/instrumentation: Floor model high speed centrifuges and KOMPSpin carbon fiber rotors; Tabletop centrifuges. Main products/instrumentation under R&D: Tabletop rotors and Personal Centrifuge, high advanced carbon fiber rotors. Subsidiary bodies: 16,000 sq ft in Kuala Lumpur, Malaysia. Sealed and granted patents: U.S. Patents #5,362,301, 5,382,219 & 5,562,582.

Research director: G. Luss R&D expertise: Development and supply of membrane filtration, separation processes, heat exchanges, process tank and vessels. Technological expertise: P/S, BA, CH/S, PMC Principal products/instrumentation: Membrane Filtration Equipment, SS tank, piping, etc. Main products/instrumentation under R&D: Separation process equipment.

798 COMPOSITE ROTOR, INC. Add: 837 2nd Avenue Redwood city, CA 94063 Tel: (650) 216-7788 Fax: (650) 216-7988

799 COMPUGEN Add: 7 Centre Dr. Jamesburg, NJ 08831 Tel: (609) 655-5105 Fax: (609) 655-5114 E-mail: [email protected] CEO: Mor Amitai Research director: Simchon Faigler R&D expertise: Development and production of computational genomics. Technological expertise: CH/S, BI Principal products/instrumentation: Leads Database, www.labon-web.com; Z3-2DGEL Software, BioXL/P, DNA chips design, Bioinformatic tools. Main products/instrumentation under R&D: Computational genomics.

E-mail: [email protected] Web site: www.composite.com President: Reza Sheikhrezai Research director: Ghassem Malekmadani R&D expertise: Development, manufacture and supply of high advanced carbon fiber rotors and tabletop centrifuges; R&D related contract for centrifugal structures. Key sales market contracts: Exclusive in Japan with Hitachi Koki and exclusive distribution for Hanil Science of South Korea. Technological expertise: P/S, C/TC, F

800 COMSTOCK, INC. Add: 1005 Alvin Weinberg Dr. Oak Ridge, TN 37830 Tel: (423) 483-7690 Fax: (423) 481-3884 E-mail: [email protected] Web site: www.comstockinc.com President: William A. Gibson Research director: Robert Haufier

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R&D expertise: Development and manufacture of Maldi Time-of-Flight mass spectrometers, electrostatic energy analyzers and charged particle detectors.

Research director: Howard Six Subsidiary of Connaught Laboratories, Ltd.

Technological expertise: Q, PMC

R&D expertise: Development and manufacture of vaccines and other biological products.

Principal products/instrumentation: Timeof-Flight mass spectrometer, Electrostatic energy analyzer, charged particle detector.

Joint ventures: Merck Vaccine Division — pediatric vaccines.

801 CONFARMA FRANCE S.A.R.L. Add: Rue Du canal D’Alsace Hombourg F. 68490 France Tel: (33) 389-83-3720 Fax: (33) 389-83-3729

Principal products/instrumentation: Fluzone, Imogarn, Imovax, Imovax ID, IPOL, Menomune; ProHibit, Theracys, Tripedia, JeVax, Tubersol, MSTA, Mono-Vacc, Multi-test CMI.

803 CONNAUGHT LABORATORIES, LTD.

E-mail: [email protected] President: Dr. W. Weyers Research director: Dr. E. Lett Subsidiary of Confarma AG Switzerland R&D expertise: Scientific research services of physicochemical tests, hygiene and microbiology, biological and toxicological tests for drug products.

Add: 1755 Steeles Ave., W. North York, Ont. M2R 3T4 Canada Tel: (416) 667-270 Fax: (416) 667-0313 President: Peter Campbell

Key sales market contracts: Cosmetics, in vitro toxicology testing, pharmaceuticals, process validation.

R&D expertise: Development and manufacture of vaccine, peptide and nucleic acid synthesis, genetic and protein engineering, hybridoma and transfectoma technology, expression and vector systems.

Main products/instrumentation under R&D: Contract research products, drug physicochemical tests, drug toxicological tests.

Principal products/instrumentation: Adult and pediatric vaccines. VAQTA, PENTA, biotherapeutic products.

Subsidiary bodies: Switzerland and Germany.

802 CONNAUGHT LABORATORIES, INC. Add: Route 611, P.O. Box 187 Swiftwater, PA 18370

804 CONNECTIVE THERAPEUTICS, INC. Add: 3400 West Bayshore Rd. Palo Alto, CA 94303 Tel: (415) 843-2800

Tel: (717) 839-4200

Fax: (415) 843-2899

Fax: (717) 839-7235

E-mail: [email protected]

President: David J. Williams

President/CEO: Thomas G. Wiggans

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Research director: Edward P. Amento, M.D. R&D expertise: Development and manufacture of biotechnology medicines for therapeutical connective tissue diseases. Key license and trade contracts: Genentech; Domain Associates; Biotechnology Investments Ltd.; The Sprout Group; GIMV; Sofinnova; Lease Management Services. Technological expertise: F, P/S, BA, H/CF, C/TC, PMC, Q, SY, DD, RD Main products/instrumentation under R&D: Relaxin, Phase I/II in scleroderma; TCR Peptides, Phase I/II in multiple sclerosis.

805 CONNEX GMBH Add: Am Klopferspitz 19 Martinsried, Bavaria D-82152 Germany Tel: (49) 89-899-6350 Fax: (49) 89-899-63528 E-mail: [email protected] Web site: www.connex.de President: Eberhard Menne, M.D.

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Rapid test for H. Pylori infections, immuno chromatographic diagnostic kits.

806 CONSARCTIC GMBH Add: Postfach 1133 Schollkrippen 63821 Germany Tel: (49) 60-248-0274 Fax: (49) 60-248-0277 President: Gundelach R&D expertise: R&D and manufacture of cell and tissue culture, bioprocess engineering products. Technological expertise: PMC, BA, BP Principal products/instrumentation: Inventory and storage systems for biological (liquid nitrogen) refrigerators and related accessories, cryopreservation products, controlled rate freezers, biological liquid nitrogen refrigerators, accessories. Main products/instrumentation under R&D: Development of biological freezing programs, cell/tissue culture products, bioprocess engineering products.

Research director: Gerhard Callmann, Ph.D. R&D expertise: Development, design and manufacture of biopharmaceuticals and immuno chromatographic diagnostic kits. R&D collaboration: Schwarz Pharma AG; Heliobacter Pylori Diagnostics. Key sales market contracts: Schwarz Pharma AG; Heliobacter Pylori Diagnostics; Worldwide distributor network for monoclonal antibodies. Technological expertise: F, RD, C/TC, CH/S, D-D, GA, HTDS, H/CF, P/S Main products/instrumentation under R&D: Contract manufacturing products, contract research/clinical trial products, several therapeutic monoclonal antibodies, preclinical;

807 CONSTANT SYSTEMS, LTD. Add: Unit F8b, Holly Farm Business Park Honiley Kenilworth, Warwickshire CVS 1NP UK Tel: (44) 0 192-648-4301 Fax: (44) 0 192-648-4521 E-mail: [email protected] Web site: www.constantsystems.com President: John Harbidge R&D expertise: Development, manufacture and marketing of cell disrupters. Principal products/instrumentation: Cell Disrupters, vaccines, diagnostics, biologicals.

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808 CONTINENTAL LABORATORY PRODUCTS Add: 5648 Copley Dr. San Diego, CA 92111

810 CONVIRON (CONTROLLED ENVIRONMENTS, LTD.)

Tel: (800) 456-7741

Add: 590 Berry St. Winnipeg, Manitoba R3H 0R9 Canada

Fax: (619) 549-7865

Tel: (204) 786-6451

President/CEO: David White

Fax: (204) 786-7736

R&D expertise: Development and manufacture of laboratory articles.

E-mail: [email protected]

Technological expertise: BME, RM, SI

President/CEO: Steven Kroft

Principal products/instrumentation: ABT (Aerosol Barrier Tips); ESP (Environmentally sensitive packaging for pipette tips), Micro Roughin Gloves, PCR Optimization kit for standard and long-distance PCR, Continental Cooler, Bench Top Microcentrifuge — Tube Cooler, reagents.

R&D expertise: Research, design, manufacture and marketing of controlled environment systems for research applications.

Main products/instrumentation under R&D: Laboratory articles.

Web site: www.conviron.com

Technological expertise: BA, AF Principal products/instrumentation: Plant growth chambers and rooms; plant production rooms; tissue culture rooms; incubators and germinators. Main products/instrumentation under R&D: Controlled environment system.

809 CONVERGENT BIOSCIENCE, LTD. Add: 27 Coronet Rd. Toronto, Ontario M8Z 2L8 Canada Tel: (416) 231-1664 Fax: (416) 231-1152 E-mail: [email protected] Web site: www.convergentbiosci.com President/CEO: Arthur H. Watson Research director: Jiaqi Wu, Ph.D. R&D expertise: Development and manufacture of innovative instrumentation supplies for bioanalytical and clinical diagnostic laboratories. Technological expertise: P/S, BA, CB, CH/S Principal products/instrumentation: Imaged capillary electrophoresis system (ICE 280). Main products/instrumentation under R&D: Innovative instruments and supplies for bioanalytical and clinical diagnostic laboratories.

811 COOK IMAGING CORP. Add: 927 South Curry Pike P.O. Box 3068 Bloomington, IN 47402 Tel: (812) 333-0887 Fax: (812) 332-3079 E-mail: [email protected] President: Charles H. Gilford, Jr. Research director: Lee Karras R&D expertise: Contract development/manufacturing of sterile biopharmaceuticals. Technological expertise: D-D, DD Principal products/instrumentation: Contract manufacturing products, Oxilan (Ioxilian) injection X-ray contrast media. Main products/instrumentation under R&D: Sterile biopharmaceuticals. Sealed and granted patents: Ioxilan.

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812 CORGENIX, INC.

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President/CEO: David P. Beck, Ph.D. Research director: David P. Beck, Ph.D.

Add: 12061 Tejon St. Westminster, CO 80234 Tel: (303) 457-4345 Fax: (303) 457-4519 E-mail: [email protected] Web site: www.corgenix.com President: Douglass T. Simpson Research director: Catherine Fink, Ph.D. Subsidiary of Corgenix Medical Corporation R&D expertise: In vitro diagnostics development and manufacture. Joint ventures: Helena Laboratories. R&D collaboration: Helena Labs, Chugai Diagnostic Sciences. Key sales market contracts: American Biochemicals & Pharmaceuticals, Chromagenix, Schiapparelli, Biopol, Cambridge, GTI. Key license and trade contracts: Kallestad.

R&D expertise: Contract R&D, conduct and support scientific research and educational programs on the causes, prevention and cure of disease through the study of cells and their molecular components and through propagation, storage and distribution of human cell cultures and their molecular components. Technological expertise: Q, C/TC, GA, P/S, RD, BI Principal products/instrumentation: Contract research/clinical trials products, genomic DNA: human, human/rodent somatic cell hybrids; Cell Culture related services: cell banking, cell culture production, cell line characterization, cryopreservation, karyotyping, mycoplasma testing, molecular biology-related services: chromosome mapping, FISH analysis, in situ hybridization RNA isolation. Main products/instrumentation under R&D: Human cell culture.

Technological expertise: PA, P/S, RDS, RPP Principal products/instrumentation: Anticardiolipin; ANA ds DNA; Protein C, Protein S, von Willebrand Factor. Main products/instrumentation under R&D: Anti-Beta-2 Glycoprotein I, submitted to FDA; Monoclonal Free Proteins, final clinical trials, other in vitro diagnostics. Sealed and granted patents: Anticardiolipin, ds DNA, ANA.

813 CORIELL INSTITUTE FOR MEDICAL RESEARCH Add: 401 Haddon Ave. Camden, NJ 08103 Tel: (856) 757-9697 Fax: (856) 964-0254 E-mail: [email protected] Web site: www.arginine.umdnj.edu

814 CORIXA CORP. Add: 1124 Columbia St., Ste. 200 Seattle, WA 98104 Tel: (206) 754-5711 Fax: (206) 754-5715 Web site: www.corixa.com Research director: Steve Reed R&D expertise: Development and manufacture of vaccines, cancer and infectious diseases drugs. R&D collaboration: SmithKline Beecham Biologicals, Heska, Inc., Diamed SA, AMRAD, Ltd., Abbott Laboratories, Inc., IMUGEN, Inc., Zambon Group SpA; Abgenix, Inc.; Zenyaku Kogyo Co.; Medarex, Inc.; Japan Tobacco Inc. Technological expertise: PA, Q, RD, GT, C/TC, HTDS, H/CF, PIS, PG

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Main products/instrumentation under R&D: Vaccines, contract research/clinical trial products, Melacine melanoma theraccine (therapeutic vaccine) for treatment of IV grade malignant melanoma, Phase III/IV; MUC-1 peptide vaccine for pancreatic cancer, Phase I/II; MPL vaccine adjuvant for allergic reaction, Phase III/IV; AnerVax-RA (peptide vaccine) for rheumatoid arthritis, Phase II/III; AnergiX.MS for multiplex sclerosis, Phase III; PVAC for psoriasis, Phase III. Vaccine for breast cancer and phoroma, Phase I/II, 2008. Ribi MPL, vaccine adjuvant treat infectious disease, Phase III/IV, 2008.

assay and cell culture ware. Devices and equipment for cell culture, both research and production and fluid filtration, single use plastic labware, glass labware, hot plates, pH meters, specimen containers, transfer pipettes, products for use in the following areas: tissue culture, assay, molecular biology, liquid handling and laboratory filtration.

Sealed and granted patents: Anergix RA (functional antigenic immunotoid therapy), rheumatoid arthritis, Phase 1b, 2008; Aner Vax RA (peptide vaccine) rheumatoid arthritis, Phase II–IV, 2008. Immunostimulant compositions comprising an amino-alkyl glucosaminide phosphate and QS-21, 7,030,094, U.S.; other patents are pending.

Add: 185 Jordan Rd. Rensselaer Technology Park Troy, NY 12180-7615

Main products/instrumentation under R&D: Cell and tissue culture.

816 COROMED, INC.

Tel: (518) 283-4000 Fax: (518) 283-1807 E-mail: [email protected] Web site: www.coromed.com President/CEO: Dale B. Evans, Ph.D. Research director: Ronald E. Weishaar, Ph.D.

815 CORNING INCORPORATED Add: Science Products Division 45 Nagog Park Acton, MA 01720

R&D expertise: Contract research of products for pharmaceutical, biotechnology medicines, and medical device industries. Joint ventures: CCS.

Tel: (978) 635-2200; (800) 492-1110

R&D collaboration: MAPI.

Fax: (978) 635-2476

Technological expertise: CC, E, CH/S, D-D, HTDS, SMC, SY

E-mail: [email protected] Web site: www.scienceproducts.corning.com President/CEO: R. Pierce Baker Research director: David Root Subsidiary of Coming Incorporated R&D expertise: Cell and tissue culture development, life science research, scale-up and batch production. Technological expertise: F, Q, GT, P/S, RD, BA, GA, SY, H/CF, C/TC Principal products/instrumentation: Complete range of laboratory plastic ware, filtration and liquid handling products, molecular biology,

Main products/instrumentation under R&D: Contract research/clinical trials products, biotechnology medicines, medical devices. Subsidiary bodies: Coromed Canada, Quebec, Canada; Coromed, SA, Buenos Aires, Argentina; Coromed, Inc., San Diego Satellite office, San Diego, California.

817 CORTECS DIAGNOSTICS, LTD. Add: Newtech Square Deeside Industrial Park Deeside CH5 2NT UK

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Tel: (44) 124-428-8888 Fax: (44) 124-428-0221 E-mail: [email protected] Web site: www.cortecs.com President: Dr. Michael Flynn Research director: Dr. Leonard Brookes R&D expertise: Manufacture of oral delivery peptides, oral vaccines, and rapid tests. Key sales market contracts: Dr. Falk Pharma GmbH. Key license and trade contracts: Boehringer Mannheim GmbH.

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Principal products/instrumentation: Magnetizable resins, hTBG, PSA, PSA-ACT, PSAfree, PSA-enzyme, PAP, hPL alM, B2M, CRP, CEA, AFP Carbohydrate Cancer Ag., Tryptase, Chymase, Ferritins, Cardiac enzymes, Streptavidin, hSHBG, hCBG. Main products/instrumentation under R&D: EMIR extraction resins, purified monoclonal and polyclonal antibodies, magnetizable resin. Sealed and granted patents: 5,790,964; 5,564,104; Magnetic isolation and purification of nucleic acids. 6,855,499, U.S.

Technological expertise: DD, D-D, PI, PIS, P/PS

819 CORTEX PHARMACEUTICALS, INC.

Main products/instrumentation under R&D: Oral salmon calcitonin, Phase III, Oral insulin, Phase II; Oral delivery peptides, Phase I; Oral vaccines, Phase I.

Add: 15241 Barranca Pkwy. Irvine, CA 92618

Sealed and granted patents: Oral delivery, Mucosal vaccines.

Research director: Gary A. Rogers, Ph.D.

818 CORTEX BIOCHEM, INC. Add: 1933 Davis St., Suite 321 San Leandro, CA 94577 Tel: (510) 568-2228 Fax: (510) 568-2467 E-mail: [email protected] Web site: www.cortex.biochem.com President/CEO: Leonard I. Karp Research director: Matt Pourfarzaneh, Ph.D. R&D expertise: Development and manufacture of proteins and enzymes, purified monoclonal and polyclonal antibodies magnetizable resins for manufacture and research, technology platform for low-level radioactive and other aqueous hazardous waste extraction. Technological expertise: BA, PA, P/S, SMC, HTDS

Tel: (714) 727-3157 Fax: (714) 727-3657 President/CEO: Dr. Vincent F. Simmon R&D expertise: Development and manufacture of innovative pharmaceuticals for the treatment of neurological and psychiatric disorders. Key license and trade contracts: University of California (AMPA receptor modulators); Georgia Tech. (Calpain inhibitors). Technological expertise: C/TC, D-D, SMC, SY Main products/instrumentation under R&D: Ampakines, Phase II; Calpain Inhibitors, Preclinical; Amyloid Antagonist (AD), preclinical; Ampakines, Phase II/IIIa, Alzheimer’s disease and schizophrenia; New Calpain Inhibitors, research; innovative pharmaceuticals for neurological and psychiatric disorders. Sealed and granted patents: Calpain inhibitors, AMPA receptor modules, spectrin breakdown assay.

820 CORVAS INTERNATIONAL, INC. Add: 3030 Science Park Rd. San Diego, CA 92121

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Tel: (858) 455-9800 Fax: (858)) 455-7895 E-mail: [email protected] Web site: www.corvas.com

R&D expertise: Supply of export laboratory equipment for life sciences including molecular biology, mainly to the Middle East.

President/CEO: Randall E. Woods

Key sales market contracts: Grant Instruments (Cambridge) Ltd.

Research director: George P. Vlasuk, Ph.D.

Technological expertise: RD, GA

R&D expertise: Research, design and development of a new generation of therapeutic agents in the fields of cardiovascular, cancer and other major diseases, Research and development of other biopharmaceuticals.

Principal products/instrumentation: Hybridization ovens, thermostatic baths, data loggers, laboratory equipment for life science.

R&D collaboration: Schering-Plough Corp. for development and commercialization of anti-thrombotics and HEPC. Pfizer, Inc., to collaborate on the development of NIF for ischemic stroke. Technological expertise: Q, E, F, P/S, PIS, D-D, COC, RD, H/CF, C/TC, SY Main products/instrumentation under R&D: rNAPc2, injectable anticoagulant, Phase III; rNIF, anti-inflammatory for ischemic stroke, Phase III; rNAPS, injectable anticoagulant, Phase II; Hepatitis C, protease inhibitor; Malaria, protease inhibitor; PAI antagonists and UFA inhibitors for the treatment of cancers especially solid-tumor cancers; rNAPc2 deep vein thrombosis, unstable angina, Phase II completed in 2008; neutrophil inhibitory factor (rNIF), strore, Phase IV, 2008. Sealed and granted patents: Title inhibitors of urokinase 6,576,613, U.S.

821 COSMARK Add: Unit 4, Station Rd. Shepreth, Royston, Herts SG8 6PZ UK Tel: (44) 176-326-2677 Fax: (44) 176-326-2676 E-mail: [email protected] President: Timothy B. Scott

822 COULTER PHARMACEUTICAL, INC. Add: 600 Gateway Blvd. South San Francisco, CA 94080 Tel: (650) 553-2000 Fax: (650) 553-2028 Web site: www.coulterpharm.com President/CEO: Michael F. Bigharn Research director: Daniel Shochaf, Ph.D. R&D expertise: Development and production of therapeutical drugs for cancer and autoimmune disease. Key sales market contracts: SmithKline Beecham. Technological expertise: SMC, PIS Main products/instrumentation under R&D: Contract manufacturing products, research/ clinical trials products, Bexxar (tositumornab and iodine I 131 tositumornab) for treatment of low-grade and transformed lowgrade non Hodgkin’s lymphoma, Phase III completed, 2008; other therapeutic drugs for cancer and autoimmune disease. Sealed and granted patents: “Method-ofuse” patent on Bexxar; Radioimmunotherapy of lymphoma using anti-CD20 antibodies, 6,565,827, U.S.

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Tel: (973) 305-8181 Fax: (973) 305-0884

Add: 210 Carnegie Center Princeton, NJ 08540

E-mail: [email protected]

Tel: 888-COVANCE

Web site: www.cpg-biotech.com

E-mail: [email protected]

President/CEO: William D. Abajian

Web site: www.covance.com

R&D expertise: Development and manufacture of Controlled Pore-Glass (CPG), Magnetic Porous Glass (MPG), supplier of DNA and RNA Synthesis Products, molecular biology kits and reagents.

President/CEO: Chris Kuebler R&D expertise: Contract research organization, development and manufacture of biotechnology medicines. Technological expertise: F, P/S, BA, C/TC, GT Main products/instrumentation under R&D: Contract manufacturing products, vaccines, reagent, antibodies, other biotechnology medicines.

824 COZZOLI MACHINE COMPANY Add: 401 East Third St. Plainfield, NJ 07060 Tel: (908) 757-2040

Technological expertise: Q, AB, P/S, SY Principal products/instrumentation: CPG (Controlled Pore-Glass), MPG (Magnetic Porous Glass), DNA and RNA Synthesis Products and Molecular Biology Kits. Main products/instrumentation under R&D: Controlled Pore-Glass Membranes, additional MPG products, and solid phase gene amplification and selection products, molecular biology kits and reagents. Sealed and granted patents: Magnetic porous glass manufacture.

Fax: (908) 757-7386 E-Mail: [email protected] Web site: www.cozzoli.com President: Frank J. Cozzoli R&D expertise: R&D and manufacture of equipment/instrumentation for pharmaceutical research.

826 CRATER CORPORATION Add: 9900 Copper Hill Rd. St. Louis, MO 63124 Tel: (314) 984-8735 E-mail: [email protected]

Technological expertise: BME, SI, BTS, R

Web site: www.craterdiagnostics.com

Principal products/instrumentation: Cleaning, filling and closing equipment, as well as container handling equipment.

President/CEO: Steven P. Van Keuren

Sealed and granted patents: Nearly 100 patents on various machinery, like ampule filling and sealing machines, and sliding valve, no-O-ring, no-packing syringes.

Research director: Dr. Phil French R&D expertise: Development and manufacture of diagnostics, pathogen detection using labeled bacertiophage and bio-luminescense. Joint ventures: Global Diagnostics. R&D collaboration: Washington University. Technological expertise: SMC, COC

825 CPG, INC. Add: 3 Borinski Rd. Lincoln Park, NJ 07035

Main products/instrumentation under R&D: E. coli OH 157; Salmonella, Listeria, pathogen detection devices.

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Sealed and granted patents: Patents applied for.

Principal products/instrumentation: SinuClear, contract manufacturing products, in vitro toxicology testing products, immunoassays. Sealed and granted patents: Sinu-Clear.

827 CREATIVE BIOMOLECULES, INC. Add: 45 South St. Hopkinton, MA 01748 Tel: (508) 782-1100 Fax: (508) 782-1541 Web site: www.creativebio.com President/CEO: Michael M. Tarnow Research director: Carl M. Cohen, Ph.D. R&D expertise: Development and manufacture of protein-based therapeutics for tissue repair. R&D collaboration: Stryker Corp., Orthopaedic reconstruction and dental therapeutics. Technological expertise: Q, TE, BA, C/TC, COC, GA, HTDS, P/S, RD, SMC, SY Main products/instrumentation under R&D: OP-1 bone graft devices; OP-1 implant (recombinant osteogenic protein-1) for treatment of non- and delayed-union fractures, fresh fractures, spinal fusion, and periodontal disease, Phase III, 2008; Other OP-1 orthopaedic and dental products — pilot and pivotal trials; Stroke recovery, preclinical; Chronic renal failure, preclinical.

828 CREATIVE SCIENCE & TECHNOLOGY Add: 3180 De la Cruz Blvd., Suite 102 Santa Clara, CA 95132

829 CRI, INC. Add: 80 Ashford St. Boston, MA 02134 Tel: (617) 787-5700 Fax: (617) 787-4488 E-mail: [email protected] Web site: www.cri-inc.com President/CEO: Peter L. Antoinette Research director: Peter Miller R&D expertise: Research and production of liquid crystal-based polarization and multispectral imaging technologies for life science applications. R&D collaboration: NEN Life Sciences. Key license and trade contracts: Marine Biology Laboratory, Woods Hole, MA. Technological expertise: HTDS, PG Principal products/instrumentation: Oocyte spindle imaging, Spindle-View 2000; MultiSpectral imaging, VariSpec; RGB Liquid crystal filter, MicroColor; Live cell imaging, CellView 2000. Main products/instrumentation under R&D: Fluorescence polarization plate reader, fluorescence multispectral imaging, liquid crystal tunable filter. Sealed and granted patents: Retardance imaging, liquid crystal tunable filters.

Tel: (408) 496-0317 Fax: (408) 272-8181 President: Ted Unarce

830 CROP GENETICS INTERNATIONAL, INC.

Research director: Dr. Karl Konstantin R&D expertise: Development of medical devices, diagnostics and immunoassay, related novel products manufacture.

Add: 4520 East West Hwy. Suite 300 Bethesda, MD 20814-3347 Tel: (410) 381-3800

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Fax: (410) 381-3840 President/CEO: Joseph W. Kelly Research director: James H. Davis, Ph.D. R&D expertise: Discovery, drug design, development and commercialization of crop protection systems which subsitute biopesticides for synthetic chemicals. Joint ventures: DuPont, insecticidal virus products. R&D collaboration: Zeneca, Incide. Key sales market contracts: Helena Chemical Co., Kleentek. Technological expertise: Q, F, RD, P/S, BA, GA, C/TC Principal products/instrumentation: Agriculture, pesticides, Kleentek disease-free, high yielding sugarcane seed products. Main products/instrumentation under R&D: Insecticidal virus products; InCide corn borer plant vaccine, advanced field trial stage; X-tend bioherbicides, initial field trial stage; crop protection systems. Subsidiary bodies: Ingleside, MD.

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Key sales market contracts: Goodwin Biotechnology Inc. Technological expertise: PA, Q, T, CB, P/S, RD Main products/instrumentation under R&D: Biomass, contract manufacturing products, urokinase, preclinical; Iduronidase, preclinical; Glucocerebrosidase, preclinical; HAS, preclinical; genetically engineering plants. Sealed and granted patents: Post Harvest Production of gene products in plants and cell culture; MEGA promoter; production of lysosomal proteins in plants.

832 CRS ROBOTICS CORP. Add: 5344 John Lucas Dr. Burlington, Ontario L7L 6A6 Canada Tel: (905) 332-2000 Fax: (905) 332-1114 E-mail: [email protected] Web site: www.crsrobotics.com President/CEO: Ralph Steedman Research director: Dr. Hansjoerg Haas, Dir. Lab Automation

831 CROPTECH CORPORATION Add: 1800 Kraft Dr. lacksburg, VA 24060 Tel: (540) 951-2888 Fax: (540) 952-2419 E-mail: [email protected] Web site: www.croptech.com President: David Radin, Ph.D. Research director: Karen Oishi, Ph.D. R&D expertise: Development, manufacture and commercialization of genetically engineered plants for cost-effective production of high-valued proteins. Joint ventures: Tobio LLC. R&D collaboration: Dyax Corporation.

R&D expertise: Standard HTS and genomic systems products based on core competencies of motion control, software and systems integration. Proprietary Open Architecture Lab Automation Software (POLARA) to control and manage automation systems; POLARA conforms to the Laboratory Equipment control Interface Standard (LECIS); Unique human scale robotic technology to perform repetitious and complex tasks; Robust peripheral storage devices to accommodate large-scale usage of compounds; Standard automated systems for DNA amplification and purification; Manufacture functional genomics systems, assay-specific automation solutions in drug development. Technological expertise: G, HTDS, GA, P/S, R, CH/S, PG, C/TC, D-D, CB

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Principal products/instrumentation: POLARA — Open Architechture Laboratory Software, human genome project, Lab automation systems and peripherals. Subsidiary bodies: CRS Nordic (Sweden). 833 CRUACHEM, LTD. Add: West of Scotland Science Park Todd Campus, Acre Rd. Glasgow, Scotland G20 OUA UK Tel: (44) 141-945-0055 Fax: (44) 141-946-0066

Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, organ transplants/culture, special pig arteries and veins, heart valves, organs; biopreparation for burns, skin grafts. Main products/instrumentation under R&D: Organ transplants, xenotransplantation. Sealed and granted patents: Patent pendings on production methods.

835 CRYOMEDICAL SCIENCES, INC.

E-mail: [email protected]

Add: 1300 Piccard Dr., Ste. 102 Rockville, MD 20850

Web site: www.cruachem.co.uk

Tel: (301) 417-7070

CEO: Maria Maccecchini

Fax: (301) 417-7077

Research director: John Ackroyd

President/CEO: J. J. Finkelstein

Subsidiary of Annovis Inc.

Research director: John G. Baust, Ph.D.

R&D expertise: Research, development and manufacture of DNA/RNA reagents; DNA and RNA custom synthesis; contract organic chemistry.

R&D expertise: Research, development, manufacture and marketing of products for use in the field of hypothermic (low-temperature) medicine.

Technological expertise: RD, P/S, SY

Technological expertise: PG, COS, CS

Principal products/instrumentation: DNA and RNA synthesis reagents; DNA extraction kits; custom synthesis service.

Principal products/instrumentation: CMS Accuprobe System: CMS Accuprobe 450 SP Console, CMS Disposable 3 mm × 4 cm Accuprobes.

Main products/instrumentation under R&D: Non-radioactive labels, DNA/RNA reagents, DNA/RNA custom synthesis. Subsidiary bodies: Annovis Inc., Aston, PA. 834 CRYOBIOGENICS CORP.

Main products/instrumentation under R&D: Hypothermic solutions, preclinical; hypothermic medicines.

836 CRYO TRACK, INC.

Add: 624 Sharon Court Woodbridge, NJ 07095

Add: 210 Silvia Ct. Los Altos, CA 94024

Tel: (732) 855-2991

Tel: (650) 941-6774

Fax: (732) 855-1801

Web site: www.cryotrack.com

President: Ari Marshall

President/CEO: Madhu Sanjanwala

R&D expertise: Xenotransplantation development and manufacture.

R&D expertise: Inventory Software development and manufacture.

Technological expertise: TE, C/TC

Technological expertise: CH/S

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Principal products/instrumentation: Inventory management software for biological, clinical and IVF samples and specimen. CryoRacks, CryoPlates, CryoPie, CryoStraw, novel inventory software.

837 CRYSTAL CHEM, INC. Add: P.O. Box 60225 Chicago, IL 60660 Tel: (773) 764-3549

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synthesis, custom peptides, endothelin, adrenomedullin 1–52, ACTH, calciteonin, amylin; CS 536 production-scale synthesizer, CS 936 manufacturing-scale peptide synthesizer, CS 736 “system 10” multiple peptide synthesizer. Main products/instrumentation under R&D: CS736-system 10 peptide synthesizer, ten different peptides simultaneously at a 0.5 mg scale; system 3 peptide synthesizer. Sealed and granted patents: 5,380,495; 5,453,487.

Fax: (773) 764-8666 E-mail: [email protected] Web site: www.crystalchem.com President/CEO: Hema Shah R&D expertise: Development and manufacture of immunochemicals and biochemicals.

839 CS BIO, INC. Add: 1300 Industrial Rd. #13 San Carlos, CA 94070 Tel: (650) 802-0880

Technological expertise: MAE, OC, CSDP

Fax: (650) 802-0944

Principal products/instrumentation: Ribonudease inhibitor, rat insulin, human proteins, HCG, a-HCG, b-HCG, polyclonal and monoclonal antibodies, Fmoc-amino acid supplement, nucleotides and nucleosides, immunochemicals, biochemicals.

E-mail: [email protected]

838 C S BIO CO. Add: 1300 Industrial Rd. San Carlos, CA 94070 Tel: (650) 802-0880 Fax: (650) 802-0944 E-mail: [email protected]

Web site: www.csbio.com President: Heng Wei Chang R&D expertise: Development of automated peptide synthesizers/contract manufacturing products. Technological expertise: PIS, P/S, SY, PS Principal products/instrumentation: Contract manufacturing products, CS Bio Manufacturing Synthesizer, CS 936; CS Bio Process Development Synthesizer, CS 536; CS Bio R&D Synthesizer, CS 336. Main products/instrumentation under R&D: Automated peptide synthesizer.

Web site: www.csbio.com Research director: Heng Wei Chang R&D expertise: R&D of manufacturing scale peptide synthesizers and custom peptide synthesis/purification. Technological expertise: CS, CH/S, PIS, P/S, SY Principal products/instrumentation: CS936-kg scale peptide synthesizer; CS536-0.5mg to 50 mg bench top peptide synthesizer, contract

840 CSL LIMITED Add: 45 Poplar Rd. Parkville, VIC 3052 Australia Tel: (61) 3-9389-1911 Fax: (61) 3-9389-1434 President/CEO: Graeme Kaufman Research director: Peter Bradley

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R&D expertise: Manufacture, development, research and marketing of cell, tissue culture and ethical healthcare products, including vaccines, plasma products, antibiotics and diagnostics. Technological expertise: RD, F, P/S, BA, C/TC, PMC, CH/S, SY, DD

842 CTBR Add: 87 Senneville Rd, Montreal, Quebec H9X 3R3 Canada Tel: (514) 630-8200 Fax: (514) 630-8230

Principal products/instrumentation: Human and veterinary vaccines and antibiotics; plasma fractions; human and veterinary diagnostic tests; cell culture reagents; Afluria influenza virus vaccine for active immunization of adults 18 and older against influenza disease caused by influenza virus subtypes A and type B present in the vaccine (1m), 2007.

E-mail: [email protected]

Main products/instrumentation under R&D: Fetal bovine serum, adult donor bovine serum, donor horse serum, bovine insulin, insulin like growth factor, serum free media, monoclonal antibodies, liquid media, enzyme solutions, antibiotics, cell lines recombinant human growth hormone; multi-component vaccines.

Technological expertise: AB, P, PS

841 CST TECHNOLOGIES, INC. Add: 55 Northern Blvd. Suite 200 Great Neck, NY 11021

Web site: www.ctbr.com President/CEO: Michael F. Ankcorn Research director: George Lulham Subsidiary of ClinTrials Research R&D expertise: Contract research and organization of biotechnology medicines. Main products/instrumentation under R&D: Biologicals, biomaterials, contract research products, in vitro toxicology testing method, pharmaceuticals, vaccines, antibodies, peptides, reagents.

843 CUBIST PHARMACEUTICALS, INC. Add: 65 Hayden Ave., Lexington, MA 02421 Tel: (781) 860-8533

Tel: (516) 482-9001

Fax: (781) 860-8538

Fax: (516) 482-0186

E-mail: [email protected]

President: Anand Akerkar, Ph.D.

Web site: www.cubist.com

Research director: Anand Akerkar, Ph.D.

President/CEO: Scott M. Rocklage, Ph.D.

R&D expertise: Research and development of artificial synthetic matrices for replacement of human serum, urine and saliva; related products manufacture.

Research director: Francis P. Tally, M.D.

Technological expertise: SY, BS Principal products/instrumentation: SeraSub; UriSub; ProDil; Ab-Coat; EnzDil; CtrlSub; SeraDil.

R&D collaboration: Bristol-Myers Squibb, Merck & Co., ArQule, Inc., Genzyme Corp., Neurogen Corp., Novalon Pharmaceutical Corp. and Pharmacopeia, Inc.

Main products/instrumentation under R&D: Synthetic saliva, artificial synthetic spinal fluid.

Technological expertise: R, SMC, AF, BI, COC, HTDS

R&D expertise: Discovery, research, development and manufacture of novel biotechnology antiinfectives.

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Principal products/instrumentation: Cubicin (Daptomycin) for the treatment of complicated skin and skin structure infections caused by susceptible strains of the following Grampositive microorganisms: Staphylococcus aureus (including methicillin-resistant strains), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subsp. equisililis and enterococcus faecalis (vancomycinsusceptible strains only), 2003. Main products/instrumentation under R&D: Intermediate-based aminoacyl-tRNA synthetase inhibitors (preclinical), novel biotechnology anti-infectives; Phase II trial of ecallantide for the reduction of blood loss volume during on-pump cardiothoracic surgery, 2009; Ecallantide is a small recombinant protein that inhibits the blood enzyme kallikrein. Sealed and granted patents: High purity lipopeptides, Lipopeptide micelles and processes for preparing same, 6,696,412, U.S.; other patents are pending.

844 CUNO INCORPORATED Add: 400 Research Pkwy. Meriden, CT 06450 Tel: (203) 238-8970 Fax: (203) 238-8977 Web site: www.cuno.com President: Mark Kachur R&D expertise: Separations products for bioprocessing, biologicals (clarification, prefiltration, sterile filtration) development. Technological expertise: P/S Principal products/instrumentation: Zetapor, ZetaPlus , Polypro-Klean, PolyProxl, Microfluor. Main products/instrumentation under R&D: Biological clarification, biological prefiltration, biological sterile filtration.

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845 CURAGEN CORPORATION Add: 322 E. Main St., Branford, CT 06405 Tel: (203) 871-4400 Fax: (203) 871-4453 E-mail: [email protected] Web site: www.curagen.com President/CEO: Jonathan M. Rothberg, Ph.D. Research director: Peter T. Lomedico, Ph.D. Subsidiary of 454 Corporation R&D expertise: Research of genomics and biopharmaceuticals, related novel products developments. R&D collaboration: Pioneer Hi-Bred International, Genentech, Biogen, Glaxo Wellcome, COR Therapeutics, Hoffman-LaRoche, Abgenix, Gemini, ONO Pharmaceutical Co. Limited, Roche Vitamins. Technological expertise: Q, BI, DD, G, HTDS, PG Principal products/instrumentation: GeneScape software for bioinformatics; GeneCalling technology for gene discovery; PathCalling technology for biological pathway drug discovery; HitCalling for multiplexed drug screening assays; SeqCalling generates sequence databases of nearly all expressed genes. Main products/instrumentation under R&D: Announced selection of 24 antibody drug targets for development with partner Abgenix on August 15, 2000; Phase II trial of CRO 11vc MMAE, an antibody-drug conjugate, for advanced breast cancer, 2009. Subsidiary bodies: Branford, CT; Alachua, FL. Sealed and granted patents: #6,057,101: covers the use of the widely validated yeast twohybrid system in an ultra high throughput manner, which enables CuraGen and its collaborators to identify protein-interadons across entire genomes, #5,977,311 and 5,986,055: (cancer implications) protect the intellectual property surrounding unique protein interactions

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that were discovered through the application and analysis of CuraGen’s high throughput functional genomics technologies and gene databases. #5,972,693: covers the apparatus and computer systems utilized in the GeneCalling system. #5,871,697: covers CuraGen’s GeneCalling technology process.

multi-product pipelines, biotechnology, pharmaceutical, plating, pulp and paper. Technological expertise: CC, F, P/S, BA, PIS Principal products/instrumentation: Optimax 6,000, specialty chemicals, cosmetics, detergents, toxic waste processing system, multi-product pipelines.

846 CURIS PHARMACEUTICALS, S.A. 848 CV TECHNOLOGIES, INC. Add: 38 Avenue Hoche Paris 75008 France Tel: (33) 1-5389-0341 Fax: (33) 1-4289-1269 E-mail: [email protected] Web site: www.curis.com President/CEO: Adil Zanfari Research director: Peter James, Ph.D. R&D expertise: Drug discovery, drug design, drug development and manufacture. R&D collaboration: CNRS, France; University of Gent, Belgium; University of Alabama, USA. Technological expertise: BI, C/TC, CC, COC, D-D, Q, PIS, P/S, SMC, SY Main products/instrumentation under R&D: Atherosclerosis QRS 10001 APO Al Analog, preclinical; Septic Shock QRS 5005 HDL LPS Complex, preclinical.

847 CUSTOM SENSORS & TECHNOLOGY Add: 7534 Watson Rd. St. Louis, MO 63119

Add: 308 Campus Tower, 8625-112 St. Ste. 308 Edmonton, AB T6G 1K8 Canada Tel: (780) 432-0022 Fax: (780) 432-7772 President/CEO: James Bruce Research director: Jacqueline J. Shan R&D expertise: Research, development, manufacture and marketing of biopharmaceutical and nutraceutical. R&D collaboration: University of Hong Kong Traditional Medicine Research Program; National Research Council. Key sales market contracts: Chembioprint USA, Boulder, Colorado. Key license and trade contracts: Axis-Shield Diagnostics-PHF Diagnostic product. Technological expertise: E, PA, PIS, SMC, SY, CB, C/TC, HTDS Principal products/instrumentation: Contract research/clinical trials products, nutraceuticals, Cold-EX (Immune Booster); Cell-FX (Arthritis); Remember-FX (Memory Function); AD-FX (Attention Deficit Disorder).

President: Mike Ponstingl

Main products/instrumentation under R&D: CVT-E002, Cold/Flu Prevention and Treatment, Phase II; CVT-E033 for treatment of attention deficit disorder, Phase II; CVT-E001 for memory impairment therapy, Phase II; CVT-E036 for depression therapy, Phase II.

R&D expertise: Development and manufacture of chemical, petrochemical, refining,

Subsidiary bodies: Newton Research Laboratory in the Newton Research Building.

Tel: (314) 962-4555 Fax: (314) 962-4385 E-mail: [email protected] Web site: www.customsensors.com

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Sealed and granted patents: Chembioprint, Process for identification, extraction and standardization of natural substances. HT1001 — Memory Function. 17 additional patents and 18 patents pending.

849 CV THERAPEUTICS, INC. Add: 3172 Porter Dr. Palo Alto, CA 94304

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Subsidiary of Advanced Cell Technology, Inc. R&D expertise: Livestock cloning research and related novel products manufacture. Principal products/instrumentation: Agriculture, mammalian cloning, livestock cloning, veterinary biologicals. Sealed and granted patents: Mammalian cloning.

Tel: (650) 812-0585 Fax: (650) 858-0390

851 CYANAMID WEBSTER PTY LIMITED

Web site: www.cvt.com CEO: Louis G. Lange, M.D., Ph.D. Research director: Richard Lawn, Ph.D. R&D expertise: Development and manufacture of small-molecule therapeutics for cardiovascular diseases.

Add: P.O. Box 234 Fort Dodge, P/L 2153 Australia Tel: (61) 02-9899-2111 Fax: (61) 02-9899-2151 E-mail: [email protected]

R&D collaboration: Biogen, Inc.; Fujisawa Healthcare.

Web site: www.ahp.com

Key sales market contracts: Biogen, Inc.; Innovex, Fujisawa Heathcare.

Research director: Dr. Philip Lehrbach

Technological expertise: C/TC, D-D, HTDS, SMC, COC, DD

R&D expertise: Research of veterinary biologicals and pharmaceuticals, related products manufacture.

Products/instrumentation under R&D: Ranolazine-metabolic modulator for treatment of chronic stable angina, Phase III/IV; CVT510-adenosine Al agonist for treatment of atrial arrhythmias, Phase II/III.

President: Tom Corcoran Subsidiary of American Home Products

Technological expertise: F, Q, RD, P/S, BA, GA, C/TC Principal products/instrumentation: Veterinary biologicals (focus on companion animal, livestock and poultry).

850 CYAGRA, LLC. 852 CYANOTECH CORP. Add: One Innovation Drive Worchester, MA USA 01605 Tel: (508) 756-1212

Add: 73-4460 Queen Kaahumanu #102 Kailua-Kona, HI 96740

Fax: (598) 756-4468

Tel: (808) 326-1353

E-mail: [email protected]

Fax: (808) 329-3597

Web site: www.cyagra.com

E-mail: [email protected]

President/CEO: Michael West

Web site: www.cyanotech.com

Research director: Jose Cibelli

President: Gerry Cysewski, Ph.D.

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Research director: L. Todd Lorenz, Ph.D.

Technological expertise: Q, BI, CH/S

R&D expertise: Development and production of Spirulina Pacifica, a nutritional supplement; development and production of phycobiliproteins for the medical diagnostics industry and Astaxanthin, a natural red pigment.

Principal products/instrumentation: Genetic analysis software, True Allele genetic discovery.

Key license and trade contracts: Stanford University, phycobiliproteins and University of Memphis, Mosquitocide, The Scripps Research Institute, catalytic antibody. Technological expertise: BA, P/S Principal products/instrumentation: Natural products, R-phycoerythrin; B-pbycoerythrin; C-phycoerythrin; Allophycocyanin; cross-linked Allophycocyanin; Spirulina, Astaxanthin. Main products/instrumentation under R&D: Cosmetic coloring agents, spirulina pacifica. Sealed and granted patents: Ocean Chill Drying #5,276,977, Integrated microalgae production #5,659,977.

Main products/instrumentation under R&D: Method system for genotyping. Sealed and granted patents: #5,541,067 — method and system for genotyping; #5,580,728 — method and system for genotyping.

854 CYBERLAB, INC. Add: 36 Del Mar Dr. Brookfield, CT 06804-2401 Tel: (203) 740-3565 Fax: (203) 740-3566 E-mail: [email protected] President: Thomas J. Friedlander R&D expertise: Robotic workstations research and related novel products manufacture. Technological expertise: R

853 CYBERGENETICS, INC. Add: 160 North Craig St., Ste. 210 Pittsburgh, PA 15213

Main products/instrumentation under R&D: Robotic workstations. Sealed and granted patents: Several patents relating to robotic workstations.

Tel: (412) 683-3004 Fax: (412) 683-3005

855 CYBERSYN, INC.

E-mail: [email protected] Web site: www.cybergenetks-inc.corn President: Ria David Research director: Mark W. Perlin R&D expertise: R&D of unique computational approaches that accelerate and simplify genetic discovery, related products manufacture. Key sales market contracts: The Math Works, Apple Computers, Adobe Systems. Key license and trade contracts: SmithKline Beecham, de-CODE genetics, N.I.H., University of Pittsburgh.

Add: 2 New Road Ste. 300 Aston, PA 19014 Tel: (800) 362-3278 Fax: (800) 362-3279 E-mail: [email protected] Web site: www.cybersyn.com President: Guy R. Washinger R&D expertise: Research of peptide instrumentation, full service DNA and RNA oligonucleotide and peptide custom synthesis; related novel products manufacture. Technological expertise: E, BI, GT, G, GA, P/S, RD, Q, SY, T, CH/S, CS, DK

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Principal products/instrumentation: DNA and RNA oligonucleotide synthesis, primers, labels, modifications, enzymes, oligos degenerate bases, mixed RNA/DNA, probes, custom peptide synthesis, high purity water and RNase.

R&D expertise: Research of drug design, drug delivery and drug formulation; novel product development.

Main products/instrumentation under R&D: Peptide synthesizer.

Principal products/instrumentation: Captisol, drug delivery route.

856 CYCLODEXTRIN TECHNOLOGIES DEVELOPMENT, INC. Add: 3713 SW 42nd Ave., Ste. 3 Gainesville, FL 32608 Tel: (352) 375-6822 Fax: (352) 375-8287 E-mail: [email protected] Web site: www.cyclodex.com President/CEO: C. E. Rick Strattan R&D expertise: Development, manufacture and marketing of cyclodextrins; research and development services; and related patent and regulatory consultation. Technological expertise: DD, D-D Principal products/instrumentation: Drug design program, drug delivery route, vaccines. Main products/instrumentation under R&D: Cyclodextrins.

Key license and trade contracts: Pfzier, Bristol Myers Squibb, Allergan, Daiichi, Peptichemio.

Main products/instrumentation under R&D: Drug formulation design.

858 CYGNUS TECHNOLOGIES Add: 95 Comstock Dr. Wrentham, MA 02093 Tel: (508) 769-8739 Fax: (508) 883-9913 E-mail: [email protected] Web site: www.cygnustechnologies.com President: Kenneth Hoffman R&D expertise: Research of biotechnology medicines and their products/process development and manufacture. Technological expertise: PA, BA Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trials products, Elisa Kits for QC; Bioprocess monitoring for detection of CHO, E. Coli, Protein A, BSA, HSA, Bovine IgG, Insulin, etc.

857 CYDEX, INC. Add: 12980 Metcalf Ave. Ste. 470 Overland Park, KS 66213

859 CYLEX, INC.

Tel: (913) 685-8850

Add: 8970 Rt. 108 Suite D, Oakland Center Columbia, MD 21045

Fax: (913) 685-8856

Tel: (410) 964-0236

E-mail: [email protected]

Fax: (410) 964-0367

Web site: www.cydexinc.com

E-mail: [email protected]

President/CEO: Peter T. Higuchi

President/CEO: Judith Britz, Ph.D.

Research director: Diane O. Thompson

Research director: Wendy Chen

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R&D expertise: Immunoassay development and research, related reagent manufacture and marketing. R&D collaboration: Maryland Industrial Partnership

CEO: Dr. Michael Pritchard/Dr. Michael Voice R&D expertise: Development and supply of reagents for the testing of human drug metabolism in vitro.

Technological expertise: E, PA, P/S, C/TC, H/CF

Key sales market contracts: Distribution agreement with Tebu International S.A. (France).

Principal products/instrumentation: Kits for immune function testing and cell mediated immunity, reagents, vaccines, antibodies.

Key license and trade contracts: Exclusive licensing agreement with University of Dundee (Scotland, UK).

Main products/instrumentation under R&D: Assay for cell mediated immunity.

Technological expertise: E, F, Q, HTDS, PG, P/S, RD

Sealed and granted patents: 5,773,232.

Principal products/instrumentation: Contract manufacturing products, in vitro technology testing method, recombinant human drug-metabolizing enzymes, Bactosomes 2000.

860 CYMBUS BIOTECHNOLOGY, LTD. Add: Unit J, Eagle Close Chandlers Ford Hants S053 4NF UK Tel: (44) 023-8026-7676

Main products/instrumentation under R&D: Additional Bactosome products, reagent for the testing of human drug metabolism in vitro.

Fax: (44) 023-8026-7677 E-mail: [email protected]

862 CYPRESS BIOSCIENCES, INC.

Web site: www.cymbus.co.uk President: Dr. Julian Miller R&D expertise: Monoclonal antibody development and production.

Add: 4350 Executive Dr. Suite 325 San Diego, CA 92121 Tel: (619) 452-2323

Technological expertise: PA, BA, H/CF, C/TC

Fax: (619) 452-1222

Principal products/instrumentation: Contract manufacturing products, biologicals.

E-mail: [email protected]

Main products/instrumentation under R&D: Monoclonal antibodies.

Research director: Mike Gerdrau, M.D.

861 CYPEX, LTD. Add: Unit 24, Prospect Business Centre, Gemini Crescent Dundee DD2 1TY Scotland Tel: (44) 0138-256-2391 Fax: (44) 0138-256-2394 E-mail: [email protected] Web site: www.cypex.co.uk

President: Deby Jo Blank, M.D. R&D expertise: Development of hematology, immunology and rheumatology device specializing in extracorporeal immuno adsorption, related novel products manufacture. Technological expertise: P/S, BS, PMC Principal products/instrumentation: Prosorba column. Main products/instrumentation under R&D: Submitted PMA for the Prosorba column in treating rheumatoid arthritis, extracorporeal immuno adsorption devices.

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heat-homogeneous DNA probe assay; molecular biology based diagnostics.

865 CYTOCHROMA, INC.

Tel: (301) 445-4220 Fax: (301) 445-4370 President/CEO: Lawrence Tamarkin, Ph.D. Research director: Giulio Paciotti, Ph.D. R&D expertise: Cytokine research, related diagnostic and therapeutic product development.

Add: 116 Barrie St., Ste. 2424 Kingston, Ontario K7L 3N6 Canada Tel: (613) 531-9995 Fax: (613) 531-6580 E-mail: [email protected]

Technological expertise: PA

Web site: www.cytochroma.com

Principal products/instrumentation: Acute EIA System; Cytelisa Kits; Cytokine and Growth Factor antibodies, Polyclonal antibodies.

President/CEO: Dr. Robert Foldes

Main products/instrumentation under R&D: Cytokine receptor, cytokine therapy. Sealed and granted patents: Composition and method for delivery of biologically-active factors. 6,374,552, U.S.; other patents are pending.

864 CYTOCELL, LTD. Add: Somerville Court Banbury Business Park, Adderbury Banbury, Oxfordshire OX17 3SN UK Tel: (44) 129-581-0910 Fax: (44) 129-581-2333 E-mail: [email protected] Web site: www.cytocell.co.uk President: Hamish Hale Research director: Don Cardy R&D expertise: Development of molecular biology based diagnostics. R&D collaboration: Mitsui Pharmaceuticals, Japan.

R&D expertise: Identification and characterization research of novel cytochrome P450 enzymes and the discovery and development of therapeutic agents modulating these enzymes, related products manufacture. R&D collaboration: Allergan Inc., John Hopkins University. Key license and trade contracts: Allergan, Inc.; PARTEQ Research and Development Innovations, Shriners Hospital for Children. Technological expertise: E, GA, G, HTDS, PA, RD, Q, SMC, BI, C/TC, CH/S, D-D, PG Main products/instrumentation under R&D: Novel cytochrome, P450 enzymes, modulating enzyme therapeutic agents, P450 RAI inhibitors, laboratory research; CYP 278 inhibitors, laboratory research; CYP 24 inhibitors, laboratory research; Phase II trial of CTAO18 injection for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease, 2008. Sealed and granted patents: Cytochroma’s patent portfolio includes exclusive licenses from PARTEQ and Shriners, and a growing portfolio of novel genes.

Technological expertise: RD, FA Principal products/instrumentation: Chromoprobe kits for detection of chromosomes using fluorescence in-situ hybridization.

866 CYTOCLONAL PHARMACEUTICS, INC.

Main products/instrumentation under R&D: Pediat-DNA probe amplification;

Add: 9000 Harry Mines Blvd. Dallas, TX 75235

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Tel: (214) 353-2922 Fax: (214) 350-9514 President/CEO: Arthur P. Bollon, Ph.D. Research director: Arthur P. Bollon, Ph.D. R&D expertise: Development and manufacture of therapeutic and diagnostic products for the treatment and prevention of cancer, viral and immune diseases.

R&D expertise: R&D of bioremediation technologies and laboratory support for field biotechnology studies, biosolvent technology for oil spill clean-ups, bioreactors 500–2000 gallons and biodiesel alternative fuel; related products manufacture. R&D collaboration: DOE and USDA Research Grants; CRADA program with DOE/Lawrence Berkeley Laboratory.

Joint ventures: Cytomune, Inc. (anti-leukemic drug).

Key sales market contracts: NOPEC Corporation.

R&D collaboration: The University of Texas (Antisense program), Montana State University (Fungal Taxol Production System), Enzon (TNF-PEG), Sloan-Kettering Cancer Center (Product for reduction of radiation damage).

Technological expertise: BTS, CB, CSDP

Key license and trade contracts: Research & Development Institute of Montana State University.

Principal products/instrumentation: Modular Bioreactor systems for groundwater; Biosolvent for oil spill clean-ups; Biodiesel alternative fuel. Main products/instrumentation under R&D: Bioremediation technologies, laboratory support for field biotechnology studies.

Technological expertise: F, Q, E, RD, P/S, BA, GA, H/CF, C/TC, D-D, AB, GT Main products/instrumentation under R&D: Taxol from Fungal Production system, Phase II; Lung cancer gene isolated, Phase II; Lung cancer MAb, Phase II clinical trials; Melanoma MAb; TNF-PEG; Novel protein for prevention of radiation and chemotherapy damage, Animal studies; Anti-leukemic drug; and vaccine program, preclinical. Subsidiary bodies: 1720 Regal Row, Suite 215, Dallas, TX 75235.

867 CYTO CULTURE INTERNATIONAL, NC. Add: 249 Tewksbury Ave. Point Richmond, CA 94801 Tel: (510) 233-0102 Fax: (510) 233-3777 E-mail: [email protected] President: Randall von Wedel, Ph.D. Research director: Randall von Wedel, Ph.D.

868 CYTODIAGNOSTICS, INC. Add: 800 Research Pky #200 Oklahoma City, OK 73104-3608 Tel: (405) 290-4000 Fax: (405) 290-4084 President/CEO: William A. Hagstrom Research director: Robert Veltri, Ph.D. R&D expertise: Comprehensive disease management research of urologic tumors and complex conditions; related therapeutical novel products manufacture. R&D collaboration: Prostate cancer and other urological diseases. Key license and trade contracts: Specific biomarker and other patented/proprietary technologies for urologic diseases. Technological expertise: P/S, GA, C/TC, CH/S, SY Principal products/instrumentation: Advanced uropathology and biomarkers for detection and

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prognosis of prostate and bladder cancer, sextant biopsy kits and source analysis for microhematuria

President/CEO: Thomas J. McKearn, M.D., Ph.D.

Main products/instrumentation under R&D: Advanced prognostic panels for prostate and bladder cancer; differential diagnostics for BPH and interstitial cystitis; therapeutics for urologic tumors.

R&D expertise: Cancer products development and manufacture.

869 CYTODYN Add: 4236 Longridge Ave. Penthouse 302 Studio City, CA 91604 Tel: (213) 525-0560 Fax: (213) 525-0870 E-mail: [email protected] Web site: www.cytodyn.com President/CEO: Allen D. Allen Research director: Allen D. Allen R&D expertise: Development and design of biotechnology medicines; related applied products manufacture. Key license and trade contracts: Vista Biologicals CORP.; Discount Medical Pharmacy. Technological expertise: F, Q, T, C/TC, CH/S, D-D, H/CF, PIS, P/S Main products/instrumentation under R&D: CYTOLIN, Phase II/III; other biotechnology medicines.

Research director: John D. Rodwell, Ph.D.

R&D collaboration: Dow Chemical. Key sales market contracts: CISbio, Faulding (Canada), DuPont Merck Pharm., CR. Bard. Key license and trade contracts: Unilever, ICRF. Technological expertise: DD, P, PI, PS, Q, RD, D-D Principal products/instrumentation: OncoScint CR/OV (satumomab pendetide) for colorectal cancer detection; ProstaScint for prostate cancer detection; Quadramet. Main products/instrumentation under R&D: OncoRad prostate, Phase III; ALT-kidney cancer, Phase Ill/treatment END; OncoScint CRIOV — breast cancer imaging, Phase III; Quadramet — bone metastases therapy, Phase II; ALT — chronic hepatitis therapy, Phase I/II. Subsidiary bodies: Cellcor, Newton, MA. Sealed and granted patents: Random peptides that bind to gastrointestinal tract transport receptors and related methods. 7,135,457, U.S.; Random peptides that bind to gastrointestinal tract (GIT) transport receptors and related methods. 6,703,362, U.S.; other patents are pending.

Sealed and granted patents: 5,651,970; 5,424,066. 871 CYTOGENIX, INC. 870 CYTOGEN CORP. Add: 600 College Rd. East Princeton, NJ 08540

Add: 9881 South Wiicrest Houston, TX 77099 Tel: (281) 988-6118 Fax: (281) 988-6727

Tel: (609) 987-8200

E-mail: [email protected]

Fax: (609) 452-2975

Web site: www.cytogenix.com

E-mail: [email protected]

President: Malcolm H. Skolnick

Web site: www.cytogen.com

Research director: Jonathan F. Elliston

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R&D expertise: Research and development of biotechnology medicines. Technological expertise: AB, C/TC, D-D, GT, PG, RD, SY Main products/instrumentation under R&D: Single-strand DNA, preclinical; Expression Technology, preclinical; other biotechnology medicines. Sealed and granted patents: U.S. Patent # 6,054,299; 8 patents pending.

872 CYTOGEN RESEARCH AND DEVELOPMENT, INC. Add: 89 Bellevue Hill Rd. W. Roxbury, MA 02132 Tel: (617) 325-7774 Fax: (617) 327-2405 President/CEO: Sona Yerganian Research director: George Yerganian, Ph.D. R&D expertise: Research of inbred and hybrid strains for Chinese hamsters, an improved variety development and production. Technological expertise: C/TC, H/CF Principal products/instrumentation: Inbred and hybrid Amerian and Chinese hamsters; embryo cell cultures; normal, benign and neoplastic cell lines of adult origins; assessment of steroids for hepatoma induction (Armtaneous and hamsters); assessment of steroids on spontaneous and induced ovarian and uterine (adeno) carcinomas (Chinese hamsters), inbred strain, hybrid strain. 873 CYTOLAB, LTD. Add: Kiryat Weizmann Science Park Rehovot 76124 Israel Tel: (972) 8-940-3302 Fax: (972) 8-940-3736 E-mail: [email protected] Web site: [email protected]

President: Zippora Stabinsky Research director: Danny Stabinsky R&D expertise: Development and manufacture of quality cytokines and antibodies. Technological expertise: PA, Q, PIS, P/S, RD Principal products/instrumentation: Cytokines; Monoclonal antibodies; Polyclonal antibodies, quality cytokines, quality antibodies.

874 CYTOMATION, INC. Add: 4850 Innovation Dr. Ft. Collins, CO 80525 Tel: (970) 226-2200 Fax: (970) 226-0107 E-mail: [email protected] Web site: www.cytotnation.com President/CEO: Nigel M. Ferrey Research director: Dr. John Griffin R&D expertise: Research and development of flow cytometry instrumentation and software, applied products manufacture. Joint ventures: XY, Inc. Key sales market contracts: La Sanitalia, Italy and Partec, Germany. Technological expertise: CH/S, C/TC, BTS, COC Principal products/instrumentation: Organ transplants/culture products, MoFlo, modular flow cytometer high speed cell sorting with 4-way sort and aerosol containment system, Summit software, flow cytometry instruments and software. Subsidiary bodies: Melbourne, Australia; Freiburg, Germany.

875 CYTOMED, INC. Add: 75 Sidney St. Cambridge, MA 02139-4134 Tel: (617) 661-3400 Fax: (617) 661-7364 President: Stephen H. Ip, Ph.D.

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Research director: Stephen H. Ip, Ph.D. R&D expertise: Development of biopharmaceutical products for inflammation, allergy and analgesia; drug response testing, toxicological testing and in vitro testing/product safety research. Related products manufacture. R&D collaboration: Chiron Corporation. Technological expertise: RD, H/CF, C/TC, SY, P/S, P/S, GT, D-D, COC Main products/instrumentation under R&D: CMT-392 (dermatological anti-inflammatory), Phase II; CAB-2 (complement inhibitor), preclinical; CMI-477 (nicotine agonist/analgesic), preclinical; biopharmaceutical for allergy drug.

876 CYTO PULSE SCIENCES, INC. Add: P.O. Box 609 Columbia, MD 21045 Tel: (410) 787-1890 Fax: (410) 787-2140 E-mail: [email protected] Web site: www.cytopulse.com President: Richard E. Walters Research director: Man D. King R&D expertise: Drug/gene delivery research using electroporation, related novel products manufacture. Technological expertise: DD, D-D Principal products/instrumentation: Electroporation equipment. Main products/instrumentation under R&D: Drug/gene delivery route; Phase II study of DNA vaccination in patients with colorectal cancer, 2009.

877 CYTOS BIOTECHNOLOGY AG Add: Wagistrasse 25, Postfach, Schlieren CH8952, Switzerland Tel: (41) 44-733-4646 Fax: (41) 44-733-4702

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E-mail: [email protected] Web site: www.cytos.com President: Prof. Dr. James E. R&D expertise: Basic and clinical research applications in flow cytometry, and the vertical integration of three proprietary platform technologies into a complementary discovery and development pipeline of new vaccines and immunotherapeutical products. Technological expertise: C/TC, GT, G, P/S, BA, D-D Principal products/instrumentation: A novel discovery and screening technology, DELphi; a temperature inducible expression system, pCytTS; a new vaccine technology, AlphaVaccine. Main products/instrumentation under R&D: New vaccines against HIV, preclinical; new vaccines against allergic diseases, preclinical; three proprietary platform technologies into a complementary drug discovery; CyTO 06-Ang Ob, a vaccine candidate for the treatment of blastoma hypertension, failed to induce a significant reduction of ambulatory blood pressure in a phase IIb trial in patients with mild to moderate hypertension, 2009. Sealed and granted patents: #5,811,299, 6 patents pending. 878 CYTOSKELETON, INC. Add: 1650 Fillmore St. Precedent Health Center #240 Denver, CO 80206 Tel: (303) 322-2254 Fax: (303) 322-2257 E-mail: [email protected] Web site: www.cytoskeleton.com President: Kim Middleton Research director: Kim Middleton R&D expertise: New drug planning and development, clinical trials, monitoring, high throughput drug screens for anti-cancer and anti-neurodegeneranve diseases.

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Key license and trade contracts: The Scripps Research Institute, Northwestern University.

880 CYTOTHERAPEUTICS, INC.

Technological expertise: HTDS, AB, D-D, RPD

Add: 701 Washington Hwy. Lincoln, RI 02865

Principal products/instrumentation: Contract research/clinical trial products, reagents, anti-cancer drug (Tubulin), anti-neurodegenerative drug (neurofilaments), high throughput screens, antibodies, recombinant protein purification tags.

Fax: (401) 334-9152

Main products/instrumentation under R&D: Novel high throughput screens, new drug planning. Sealed and granted patents: Pending formulations for HTS.

879 CYTOTECH Add: Symbion Science Pk. Fruebjergvej 3 Copenhagen DK 2100 Denmark Tel: (45) 39-179-955 Fax: (45) 39-292_954 E-mail: [email protected] Web site: www.cytotech.dk President/CEO: Patrick Munch-Fals R&D expertise: Development of biotechnology, cell culture, molecular biology, low temperature freezers and electrophoresis. Joint ventures: Nota Bene Scientific, Utilis Scientific Ltd. Key sales market contracts: BioWhittaker/ Clonetics, Harlan Sera-Lab. Technological expertise: F, PA, C/TC, CB, BME Principal products/instrumentation: Biologicals, diagnostics, clinical tests, biomaterials, reagents, instruments. Main products/instrumentation under R&D: Cell culture, low temperature freezers.

Tel: (401) 288-1000 E-mail: cyto.com Web site: www.cyto.com President: Dr. Sandra Nusinoff Lehman Research director: Lars Wahlberg, M.D., Ph.D. R&D expertise: Drug development of all major therapeutic areas, including vaccines and biotechnology based products, as well as diagnostic products development of novel cell therapy systems designed to deliver therapeutic substances to the central nervous system (CNS). Focuses on treatment of CNS diseases using its capsules to deliver proteins within the central nervous system, bypassing the bloodbrain barrier, a fundamental obstacle to effective treatment of many CNS diseases; related novel products manufacture. Joint ventures: T Cell Sciences, Inc. — Complement Receptor 1; Astra AB — Chronic Pain; Genentech, Inc. — Neurotrophic Factor Delivery to the CNS; NeuroSpheres, Ltd. — Neural stem cell technology; Akzo/Membrana — membranes for encapsulated cell and gene therapy; Cognetix, Inc. — cell and gene-based therapies. Technological expertise: C/TC, DD, GT Main products/instrumentation under R&D: Pain Cell Therapy, Phase II, Europe (chronic pain/cancer); Encapsulated-cell Delivery of CNTF, Pilot Clinical (ALS); NeuroCRIB, preclinical (Parkinson’s disease); Growth Factors for Parkinson’s and Huntington’s disease; ALS Research; Neural Stem Cells for Parkinson’s Research; for Alzheimer’s Research; for MS Research; for pain, Phase II/III (cancer/neuropathic); ACTID — Phase III/ ACTID (chronic pain); NeuroCRIB Parkinson’s,

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preclinical; Growth Factors, preclinical; Neural Stem Cells; CRIB delivery of CNTF for ALS, pilot clinical, Europe. Subsidiary bodies: Pilot manufacturing plant: Lincoln, RI.

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882 CYTOVIA, INC. Add: 6650 Nancy Ridge Drive San Diego, CA 92627 Tel: (619) 860-0500 Fax: (619) 860-2300

881 CYTOVAX BIOTECHNOLOGIES, INC.

E-mail: [email protected] Web site: www.cytovia.com President/CEO: Eckard Weber, M.D.

Add: 8925 51 Avenue Ste. 308 Edmonton, Alberta T6E 5J3 Canada

Research director: Ben Tseng, Ph.D.

Tel: (780) 448-0621

R&D expertise: Drug discovery, drug design and development; Apoptosis manufacture.

Fax: (780) 448-0624 E-mail: [email protected]

R&D collaboration: Aurora Bio-Sciences Corp.

Web site: www.cytovax.com

Technological expertise: HTDS

President/CEO: Bin Huang, Ph.D.

Main products/instrumentation under R&D: Caspase inhibitors and activators, preclinical; apoptosis drug discovery route.

Research director: Andy Stevens, Ph.D. R&D expertise: Development, design and manufacture of rationally designed synthetic peptide-based vaccines, therapeutic MAbs and clinical diagnostics.

883 CYTRX CORPORATION

Technological expertise: P/S, SY, D-D, DD, PIS, DK, AB

Add: 154 Technology Pkwy. Norcross, GA 30092

Principal products/instrumentation: Collect cell enriched immunocolumns for T-cell and CD4, CD8 cell separation kits for human species, cell separation kits for specializations, Celled (???) — immunological cell separation kits for human, mouse and rat species. Accu-MAb Plus — whooping cough diagnostic.

Tel: (770) 368-9500

Main products/instrumentation under R&D: Rationally designed synthetic peptide-based vaccines, therapeutic MAbs, synthetic vaccines and antibody therapeutics against Pseudornonas aeruginosa, and Candida albicans and other pathogens. Subsidiary bodies: GMP laboratory for topic production.

Fax: (770) 368-0622 E-mail: [email protected] Web site: www.cytrx.com President/CEO: Jack J. Luchese Research director: R. Martin Emanuele, Ph.D. R&D expertise: R&D of pharmaceuticals and human therapeutics; related applied products manufacture. R&D collaboration: Connaught Labs, Medeva — through subsidiary Vaxcel, Inc. Key license and trade contracts: Corixa Corporation — through subsidiary Vaxcel, Inc.

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Technological expertise: C/TC, DD, D-D, PMC, SY, P/S

Fax: (45) 44-85-9595

Principal products/instrumentation: TiterMax.

President: Jes Ostergaard

Main products/instrumentation under R&D: FLOCOR, for vaso-occlusive crisis (VOC) of sickle cell disease, Phase III/IV; ProTox, serious infectious diseases, opportunistic infections, Phase II; Optivax (Vaxcel-CytRx subsidiary), vaccine delivery system, Phase II; Non-antibiotic food animal growth promotant, R&D. Sealed and granted patents: All CytRx and subsidiary technologies are well protected by worldwide patents.

Web site: www.dako.com R&D expertise: Research and development of immunohistochemistry, flow cytometry, clinical chemistry, and microbiology; related products manufacture. Technological expertise: E, PA, BA, C/TC, GA, PIS, PMC, P/S, RD, SY Principal products/instrumentation: Agriculture, biologicals, contract manufacturing products, contract research/clinical trials products, diagnostics, instruments, reagents. Main products/instrumentation under R&D: Flow cytometer.

884 CYTYC CORPORATION Add: 85 Swanson Rd. Boxborough, MA 01719 Tel: (978) 263-8000 Fax: (978) 635-1033

886 DALTON CHEMICAL LABORATORIES, INC.

E-mail: [email protected]

Add: 349 Wildcat Rd. Toronto, ON M3J2S3 Canada

Web site: www.cytyc.com

Tel: (416) 661-2102

President/CEO: Patrick J. Sullivan

Fax: (416) 661-2108

R&D expertise: Development of women’s healthcare; ThinPrep Pap Test; related applied products manufacture.

E-mail: [email protected]

Technological expertise: BI, CH/S, R Principal products/instrumentation: ThinPrep Pap Test; ThinPrep 2000 System; PreservCyt Solution; Cytolyt Solution; ThinPrep Microscope Slides; Blue TransCyt Filters. Main products/instrumentation under R&D: ThinPrep 3000 System, women’s healthcare products.

885 DAKO A/S Add: Produktionsvej 42 Glostrup, DK 2600 Denmark Tel: (45) 44-85-9500

Web site: www.dalton.com President: Peter Pekos Research director: Dr. Natalie Lazarowych R&D expertise: Research of peptide synthesis, and peptide chemistry, peptide mimetics, amino acid derivative manufacture, custom chemical synthesis, contract research. Technological expertise: CC, AB, COC, SMC, SY Principal products/instrumentation: Biological, specialty chemicals, contract manufacturing products, contract research/clinical trial products, pharmaceuticals, reagents. Main products/instrumentation under R&D: Peptide synthesizer, peptide mimetics, amino acid derivative.

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887 DAN FISH FARMS Add: Kibbutz Dan Upper Galilee 12245 Israel

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889 DATAWAVE TECHNOLOGIES

Tel: (972) 6-690-2411

Add: 380 Main St., Suite 209 Longmont, CO 80501

Fax: (972) 6-690-2412

Tel: (303) 776-8214

E-mail: [email protected]

Fax: (303) 776-8531

Research director: Avshalom Hurvitz

E-mail: [email protected]

R&D expertise: Development and manufacture of breeding to sturgeons and salmon fish. R&D in fish vaccines and vaccination systems.

Web site: www.dwavetech.com

Principal products/instrumentation: Contract research/clinical trials products, vaccines. Main products/instrumentation under R&D: Fish vaccines, vaccination systems.

888 DARWIN MOLECULAR CORP. Add: 1631 220th St. SE Bothell, WA 98021 Tel: (206) 489-8000 Fax: (206) 489-8019 CEO: Ronald E. Cape, Ph.D. (interim)

President/CEO: Curt Ketner R&D expertise: Development and manufacturing of data acquisition and analysis software for scientific research, drug safety database research, related applied software products manufacture. Technological expertise: CH/S, BTS Principal products/instrumentation: Experimenter’s professional Workbench, Discovery CP Analysis, UFF Programmer’s Library, Camera Tracking System, Amplifiers, SciWorks Data Manager. Main products/instrumentation under R&D: Windows 95/NT Data acquisition and analysis software products, drug safety database.

Research director: David J. Galas, Ph.D. R&D expertise: Applications research of gene discovery, gene analysis, molecular biology, combinatorial chemistry and bioinformatics to discover and develop new therapeutics and diagnostics for human disease. Key license and trade contracts: University of Washington — T-Cell Receptor Technology. Technological expertise: CH/S, GT, D-D, DDI, CS, C, HTDS, BI, COC Principal products/instrumentation: Diagnostics, human genome project, biopharmaceuticals, contract R&D drug products. Main products/instrumentation under R&D: Gene discovery technologies, new therapeutics and diagnostics for human disease.

890 DATAWORKS DEVELOPMENT, INC. Add: P.O. Box 174 Mountlake Terrace, WA 98043 Tel: (425) 741-1411 Fax: (425) 745-1471 E-mail: [email protected] Web site: www.dwdev.com President: Cheryl Michels R&D expertise: Software research, development and manufacture. Technological expertise: CH/S Principal products/instrumentation: Freezerworks 5.0 — 2000, Clinical Laboratory Inventory Program; Contract research/clinical trial products, data development software.

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891 DAVIDS BIOTECHNOLOGLE

893 DAZDAQ LIMITED

Add: Karl Anselm Str. la Regensburg D-93053 Germany

Add: 4 Acorn House The Broyle, Ringmer, East Sussex BN8 5NW UK

Tel: (49) 941-948-228

Tel: (44) 127-381-4414

Fax: (49) 941-946-8119

Fax: (44) 127-381-4999

E-mail: [email protected]

E-mail: [email protected]

Web site: www.dabio.de

Web site: www.dazdaq.com

President: Dr. J. Davids

President: Darren Cook

R&D expertise: Development and production of customized antibody.

R&D expertise: Development and manufacture of software for the scientific instrument and diagnostics markets.

Technological expertise: E, F, PA, TE, PIS, P/S, RD, C/TC, H/CF Principal products/instrumentation: Contract research/clinical trial antibody products, natural products, polyclonal egg yolk antibody, monoclonal antibody, other biotechnology products.

Technological expertise: CH/S, H/CF, HTDS, BI, COC Principal products/instrumentation: Analytical and control software. Main products/instrumentation under R&D: New software for scientific instruments. Subsidiary bodies: Instrument control.

892 DAVIS SEQUENCING, LLC.

894 DCI, INC.

Add: 140 B St., Ste. 4 Davis, CA 95616

Add: P.O. Box 1227 St. Cloud, MN 56302

Tel: (530) 297-5038

Tel: (320) 252-8200

Fax: (530) 297-5039

Fax: (320) 252-0866

E-mail: [email protected]

E-mail: [email protected]

Web site: www.davissequencing.com

Web site: www.dciinc.com

Research director: Eric Bowman

President: Gary Kittleson

R&D expertise: DNA sequencing development services to both university and private sector customers.

R&D expertise: Custom development and manufacture of stainless steel storage and process vessels for pharmaceutical and biotech industries.

Technological expertise: Q, GA, P/S, RD, P/PS

Technological expertise: BME

Principal products/instrumentation: Biologicals, bioremediation, contract development products. Main products/instrumentation under R&D: DNA sequencer, DNA sequence analytical devices.

Main products/instrumentation under R&D: Process vessels, stainless steel storage equipment.

895 DEBIO R.P. Add: Route Du Levant 146 Martigny 1920 Switzerland

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Tel: (41) 277-21-7900

Tel: (49) 6181-594190

Fax: (41) 277-21-7901

Fax: (49) 6181-594308

Web site: www.debio.com

E-mail: [email protected]

President: Dr. Piero Orsolini

Web site: www.degussa.de

R&D expertise: Development of injectable controlled-release formulations for peptides, proteins and anti-cancer drugs; related novel products manufacture.

President: Dr. Bufe

Technological expertise: DD, PS, P/PS, PI, P, SAADP Principal products/instrumentation: Triptorelin, Decapeptyl. Main products/instrumentation under R&D: Injectable controlled-release formulations for peptides, protein and anti-cancer drugs.

896 DEGREMONT INFILCO, LTD. Add: 20275, Clark Graham Baie d’Urfe, Quebec H9X 3T5 Canada Tel: (514) 457-4100 Fax: (514) 457-1808 E-mail: [email protected] President: Harvey Mitchell

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Research director: Dr. Klaus Hutchmacher Joint ventures: Ferman S.R.O. (Slovakia), Midwest Lysine (USA), Vitachem Comp. (USA), Degussa Antwerpen N.V. Feed Additive Division (Belgium), Degussa Corp. Feed Additive Division (USA). R&D expertise: Development of biotechnology medicines. R&D collaboration: LION bioscience AG (Germany). Technological expertise: BI, BA, CH/S, GA, P/S, RD Principal products/instrumentation: DLMethionine, L-Lysine, L-Threonine, Feed Enzymes, Mepron M85, Biolys60. Main products/instrumentation under R&D: Ammo Acids (feed additive); Vitamins (feed additive); Enzymes (feed additive). Sealed and granted patents: Nucleotide sequences coding for the cls gene, 6,562,607, U.S.

Research director: Jean-Yves Bergel Subsidiary of Degremont Group

898 DEKALB GENETICS CORPORATION

R&D expertise: Research of water and wastewater treatment, related applied products manufacture.

Add: 3100 Sycamore Rd. DeKalb, IL60115

Technological expertise: BA, ERT, E, BC, BA

Tel: (815) 758-3461

Principal products/instrumentation: Toxic waste processing system, DIAPAK; BRM (biological membrane reactor).

Fax: (815) 758-3711

Main products/instrumentation under R&D: Water and wastewater treatment/equipment.

897 DEGUSSA, AG. Add: Weissfrauenstrasse 9 Frankfurt/Main 60287 Germany

Web site: www.monsanto.com President: Richard O. Ryan R&D expertise: Genetically improve research, produce and market agricultural seeds, hybrid breeding swine and egg-laying breeding poultry. Technological expertise: Q, T, RD, C/TC Principal products/instrumentation: Agriculture Hybrid corn, sorghum, forage sorghum, sorghum-sudax grass, sunflowers; varietal

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soybeans, alfalfa; hybrid breeding swine, egglaying breeding poultry. Main products/instrumentation under R&D: Herbicide resistant corn, insect resistance, drought tolerance, grain quality, breeding swine, breeding poultry, agricultural seeds. Sealed and granted patents: Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction. 6,271,016, U.S.

Technological expertise: C/TC, BTS, CB Principal products/instrumentation: Polyvalent bacterial antigen — Staphage Lysate (SPL) for human use; Staphylococcus Aureus Phage Lysate — Staphage Lysate (SPL) for veterinary use. Main products/instrumentation under R&D: Immunotherapeutics.

901 DELTA A.I.C. 899 DEKRA CERTIFICATION SERVICES (DCS) GMBH

Add: 2 Rue Jobbe-Duval Paris 75015 France Tel: (33) 1-565-66043

Add: Schulze-Delitzsch-Strasse 49 Stuttgart D-70565 Germany Tel: (49) 0711-17861-2566 Fax: (49) 0711-17861-2615 President: Lothar Winterhalder R&D expertise: Certification development of medical products and management systems, related applied products manufacture. Technological expertise: BME, BA Joint ventures: SEMRO AB and JTS. Principal products/instrumentation: Contract manufacturing products, GS, CE, S, ETL, marks 350 9000, OS 9000, VDA 6.1, KBA, JSO 1400N, 200 voltage directive, electromagnetic compatibility, medical device directive, active implantable medical device.

900 DELMONT LABORATORIES, INC.

Fax: (33) 1-425-05474 E-mail: [email protected] President: Airne Menassa Research director: Frederic Petillot R&D expertise: Agro-food business. Joint ventures: SOMAIG SA (microalgen production); BILBOA International Ltd. (Ginkgo biloba extract). Technological expertise: P/S, BA, PIS, P, PS Principal products/instrumentation: Contract manufacturing products, herbal extracts, peptide extracts, lipid extracts. Main products/instrumentation under R&D: Peptides, lipids from algae, biloba extract, microalgen products.

902 DELTATRAK, INC.

Add: 715 Harvard Ave. P.O. Box 269 Swarthmore, PA 19081

Add: P.O. Box 398 Pleasanton, CA 94566

Tel: (610) 543-2747

Fax: (925) 467-5949

Fax: (610) 543-6298

E-mail: [email protected]

Web site: www.delmont.com

Web site: www.deltatrak.com

President: David J. Ganfield, Ph.D.

President: Fred Wu

Research director: Mong Ching Ganfield Ph.D.

Research director: Richard Foreman

R&D expertise: Research of immunotherapeutic, related novel products manufacture.

R&D expertise: Temperature monitoring, measuring, validating and archiving.

Tel: (925) 467-5940

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Technological expertise: CH/S, PMC

E-mail: [email protected]

Principal products/instrumentation: Contract manufacturing products, Dataloggers, Flash Link; logging thermocouple, TQM-500; waterproof digital probe thermometers, Professional series; infrared thermometer, Thermotrace.

Web site: www.dendreon.com

903 DEMEGEN, INC. Add: 10S1 Brinton Rd. Pittsburgh, PA 15221 Tel: (412) 241-2150 Fax: (412) 241-2161 E-mail: [email protected] Web site: www.demegen.com President: Richard D. Ekstrom

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President: Christopher S. Henney, Ph.D., D.Sc. Research director: David Urdal, Ph.D. R&D expertise: Immunotherapy research for the treatment of cancer, related novel products manufacture. R&D collaboration: Kirin. Key license and trade contracts: Kirin, BioTransplant Inc., Osiris. Technological expertise: D-D, DD, C/TC, PIS, P/S Principal products/instrumentation: Reagents, Provenge, Mylovenge; DACS SC (stem cell enrichment device) for cell/tissue therapy of high dose chemotherapy.

Main products/instrumentation under R&D: Peptides for anti-infective and anti-cancer.

Main products/instrumentation under R&D: Therapeutic, dendritic cell-based cancer vaccines: Provenge in Phase III/IV for treatment of prostate cancer; Mylovent in Phase III for multiple myeloma; additional vaccine candidates in preclinical development; apc gose immune-based therapy, for treatment of multiple myeloma, Phase III–IV, 2008; APC goes immune-based therapy, for treatment of prostate cancer, Phase III completed 2008; APC 8015 immuno-based therapy for prostate cancer, Phase III/IV, 2008; APC 8020 immunebased therapy for multiple myeloma; Phase II trial of D3263 in patients with advanced cancer, 2009; D3263 is a small molecule drug candidate designed to target TRP M8 (transmembrane cation channel protein) in cancer cells to induce cell death.

Sealed and granted patents: U.S. 5,811,654.

Subsidiary bodies: Mountain View, CA.

Research director: Jesse M. Jaynes, Ph.D. R&D expertise: Research, design and development and manufacture of peptides for antiinfective and anti-cancer applications and genes for plants to enhance disease resistance and nutrition. R&D collaboration: U.S. Department of Agriculture, NIH, Avigenics. Key license and trade contracts: Dow AgroSciences. Technological expertise: T, AF, BA, DD, D-D, PIS, RD, SY Principal products/instrumentation: Agriculture, biologicals, biomaterials, pharmaceuticals.

904 DENDREON CORP.

905 DENDRITECH, INC.

Add: 3005 First Ave. Seattle, WA 98121

Add: 3110 Schuette Dr. Midland, MI 48642

Tel: (206) 256-4545

Tel: (517) 496-2018

Fax: (206) 256-0571

Fax: (517) 496-2051

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Web site: www.dendritech.com

907 DENVILLE SCIENTIFIC, INC.

President/CEO: Robert M. Nowak, Ph.D. Research director: Mark E. Kaiser

Add: South Plainfield, NJ 07080

R&D expertise: Research, development, manufacture and licensing of STAR-BURST dendrimer technology.

Tel: (908) 757-7577 Fax: (908) 757-7551 E-mail: [email protected]

R&D collaboration: University of Michigan, University of London.

Web site: www.denvillescientific.com

Key sales market contracts: Aldrich Chemical, Inc.

Research director: W. Demsia

President/CEO: W. Demsia

Key license and trade contracts: Dade International, Inc.; DSM.

R&D expertise: Development and manufacture of bioresearch instrumentation.

Technological expertise: AB, DD, SY, DT

Technological expertise: GA, P/S, RD, R, BME

Principal products/instrumentation: Diagnostics, pharmaceuticals, reagents, star-burst dendrimer.

Principal products/instrumentation: Microcentrifuge “Micro 240A”; Pipettor “XL-3000”; Benchtop Tube Cooler “Chillette”.

Main products/instrumentation under R&D: STAR-BURST dendrimer technology. Sealed and granted patents: Broad dendrimer composition of matter and application patents.

908 DEPOIVIED, INC. Add: 1360 O’Brien Dr. Menlo Park, CA 94025 Tel: (650) 462-5900

906 DE NOVO ENZYME CORPORATION

Fax: (650) 462-9993 Web site: www.depomedinc.com President/CEO: John W. Fara, Ph.D.

Add: 8081 Lougheed Highway Burnaby, B.C. VSA 1WG Canada Tel: (604) 415-7180 Fax: (604) 415-7185 E-mail: [email protected] President/CEO: Thor Borgford Research director: Dr. Curtis Braun R&D expertise: Development and manufacture of therapeutics for tumors and antiviral diseases. Technological expertise: E, F, RD, C/TC, COC, PIS Main products/instrumentation under R&D: Contract research/clinical trial products, ProteoLink Technology, preclinical; therapeutics for tumors and antiviral diseases. Sealed and granted patents: Various.

Research director: Bret Berner, Ph.D. R&D expertise: Development and design of new and proprietary oral drug delivery systems, Gastric Retention (GR) System and Reduced Irritation (RI) system; related products manufacture. Joint ventures: Elan — to develop JT, gastricretentive, delivery technician. R&D collaboration: Johnson & Johnson to develop a product based on a J&J proprietary drug and the GR System, AVI BioPharm and Depomed to explore optimizing oral delivery of AVI’s proprietary antisense technology. Technological expertise: DD, AS Main products/instrumentation under R&D: J&J/GR system, feasibility; new and proprietary oral drug systems, gastric retention system, reduced irritation system.

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Sealed and granted patents: Sustained-release oral drug dosage form, U.S. patent 5,007,790: Alkyl-substituted cellulose-based sustainedrelease oral drug dosage forms, patent 5,582,837.

909 DEPRENYL ANIMAL HEALTH, INC. Add: 10841 West 87th St., Suite 400 Overland Park, KS 66214 Tel: (913) 338-2120 Fax: (913) 338-3804 Web site: www.deprenyl.com President/CEO: David R. Stevens Research director: William W. Ruehl, VMD, Ph.D.

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Tel: (602) 460-0976 Fax: (602) 460-0976 President: Thomas Messano R&D expertise: Development of blood substitutes and other biotechnology medicines, related applied products manufacture. Key sales market contracts: Boval Co., Clebume TX — Bovine Albumins, Trace America, New Zealand Proteins. Technological expertise: P/S, C/TC, H/CF, BS Principal products/instrumentation: Bovine albumin, bovine immunoglobulin. Main products/instrumentation under R&D: Blood substitute, other new biotechnology medicines.

Subsidiary of Draxis Health Inc. R&D expertise: Pharmaceutical research, development, production and marketing — focus on veterinary drug. Joint ventures: Comprehensive license and supply agreement with Hoechst Veterinae, Wiesbaden, Germany for registration and distribution of Anipryl in select European countries. R&D collaboration: Hoechst Veterinae, Wiesbaden, Germany. Key sales market contracts: Hoechst Veterinae, Wiesbaden, Germany, Draxis Health, Canada. Key license and trade contracts: Hoechst Veteriane, Wiesbaden, Germany. Technological expertise: BME, COC, COS Main products/instrumentation under R&D: Anipryl (selegiline hydrochloride) in pivotal (Phase III/IV equivalent) clinical trials for treatment of canine Cushing’s disease and canine cognitive dysfunction, veterinary vaccines.

910 DESERT BIOLOGICALS Add: 815 East Desert Trumpet Rd. Phoenix, AZ 85048

911 DESERT ENERGY RESEARCH, INC. Add: 776 Word Valley Trail St. Charles, MO 63304 Tel: (636) 922-0188 President: Benjamin Moll Research director: Benjamin Moll R&D expertise: Research and development of novel seawater irrigated crops, and integrated very low pollution farming. Key license and trade contracts: Technology licensed for production of a family of seaweed based nutraceuticals. Technological expertise: C/TC, DD, G, T Main products/instrumentation under R&D: High protein animal feed ingredient, scale-up to commercial; dietary supplements for delivery of trace elements and other micronutrients, scale-up to commercial; novel seawater irrigated crops. Subsidiary bodies: Pilot farm in Mexico. Sealed and granted patents: Low-cost, high protein sea water irrigation farming.

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912 DESMOS INCORPORATED

914 DEVARON, INC.

Add: 3550 General Atomics Ct. B2-503 San Diego, CA 92121

Add: 2245 Rt 130 Ste. 103 Dayton, NJ 08810

Tel: (619) 455-3708

Fax: (732) 274-0067

Fax: (619) 455-3962

E-mail: [email protected]

E-mail: [email protected]

Web site: www.devaron.com

Web site: www.desmos.com/desmos

President/CEO: Dr. Y. Devash

President/CEO: Richard T. Haiduck Research director: Mary Harper, Ph.D. R&D expertise: Research of cells adhere, cell migrate, cell communicate and cell differentiate; applied products manufacture. Joint ventures: Guidant Corporation. R&D collaboration: Baxter Healthcare Corp. Technological expertise: TE, P/S, C/TC, BA, GT

Tel: (732) 274-0080

R&D expertise: Research and manufacture of reagents and rapid diagnostic test, supply reagents and novel products. Technological expertise: PA, RD, AB, P/S, PIS Principal products/instrumentation: Recombinant HIV, HTLV, HCV proteins; monoclonal antibodies; polyclonal antibodies; colloidal gold conjugates.

Main products/instrumentation under R&D: Organ transplants/culture products, preclinical; growing pancreatic islet cells in culture for transplantation, preclinical; treatment for periodontal disease, preclinical; biocoating for medical devices; cell adhere molecule.

Main products/instrumentation under R&D: Reagent, rapid diagnostic test.

Sealed and granted patents: 9 issued patents.

Add: Technologiepark 9 Zwijnaarde 9052 Belgium

915 DEVGEN NV

Tel: (32) 9-324-2424 913 DEVA BIOTECH, INC.

Fax: (32) 9-324-2425

Add: 2935 Byberry Rd. Hatboro, PA 19040

E-mail: [email protected]

Tel: (215) 675-7630

Web site: www.devgen.com

Fax: (215) 957-1218

President: Dr. Thierry Bogaert

President: V. Mahadevan, Ph.D.

Research director: Dr. Robin Brown

Research director: V. Mahadevan, Ph.D.

R&D expertise: Development of pharmaceuticals and agrochemicals, related novel products manufacture.

R&D expertise: Development and manufacture of lipid biochemicals and other biopharmaceuticals. Technological expertise: P/S, SY Principal products/instrumentation: Lipid Biochemicals, vaccines, antibodies. Main products/instrumentation under R&D: New biopharmaceuticals.

Joint ventures: Janssen Pharmaceutics. R&D collaboration: FMC Corp; Janssen Pharmaceuticals. Technological expertise: HTDS, BI, COC, G Main products/instrumentation under R&D: Therapeutic grade proteins for diabetes, heart

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failure, polycystic kidney disease, psychosis; agrochemicals.

916 DEWS RESEARCH LABORATORIES Add: Mineral Wells, TX 76068-0637 Tel: (940) 325-0208 Fax: (940) 328-1439

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Principal products/instrumentation: Contract manufacturing products, natural products, organ transplants/culture, catalogue of oligoaccharides and glycoconjugates — continual introduction of new product. Combinatorial libraries. Main products/instrumentation under R&D: Complex glycoconjugates, custom carbohydrate synthesis.

E-mail: [email protected] President: J. K. Dews Research director: I. K. Dews

918 DEXTRAN PRODUCTS LIMITED

R&D expertise: Product development, manufacturing and packaging of nutraceuticals and cosmeceuticals.

Add: 421 Comstock Rd. Scarborough, Ontario MIL 2H5 Canada

Technological expertise: AF, AB, BI, CB, C/TC, COC, CH/S, DD, D-D, GA, E, F, Q, PG, PMC, P/S, RD, SMC, SY

Fax: (416) 755-0334

Principal products/instrumentation: Health and beauty, contract manufacturing products, contract research/clinical trials products, minerals, natural products, health nutraceuticals.

917 DEXTRA LABORATORIES, LTD.

Tel: (416) 755-2231 President: George Usher Subsidiary of Polydex Pharmaceuticals R&D expertise: Development and manufacture of bloods and cell/tissue culture. Technological expertise: F, C/TC, P/S, BA Principal products/instrumentation: Iron dextran solutions, Clex FBS replacement for cell culture, DEAE dextran, dextran sulphate, fetal bovine serum, dextran serum substitute.

Add: The Science & Technology Centre The University Earley Gate, Whiteknights Rd., Reading RG6 6BZ UK

Main products/instrumentation under R&D: Cell/tissue culture, bloods and blood substitute.

Tel: (44) 118-935-7000

Subsidiary bodies: 1401 Neptune Dr., Boynton Beach, FL 33426.

Fax: (44) 118-926-7917 E-mail: [email protected] Web site: www.dextra-labs.co.uk

919 DGI BIOTECHNOLOGIES, L.L.C.

President: A. J. Hacking, Ph.D. Research director: C. J. Lawson, Ph.D. R&D expertise: Development and manufacture of complex oligosaccharides and glycoconjugates; carbohydrate analysis research.

Add: 40 Taimadge Rd. P.O. Box 424 Edison, NJ 08818-0424 Tel: (732) 287-2034 Fax: (732) 287-1486

Joint ventures: The Technology Partnership, UK.

E-mail: [email protected]

Technological expertise: CC, P/S, CB, COC, D-D, SY, SMC

Web site: www.dgibt.com President: Dr. Arthur J. Blume

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R&D expertise: Discovery research, development and production of small molecular drug candidates for a wide array of diseases by using company proprietary in vitro Diogenesis site-directed HTS assay platform. Technological expertise: C/TC, D-D, CH/S, HTDS, PIS, PG, P/S, RI, F, X, Q, SMC Principal products/instrumentation: GRABLIB phage displayed human genomic recombinant antibody libraries; RAPIDLIB phage displayed 20–40 amino acids random peptides libraries; DIOGENESIS service to establish and run automated HTS site-directed in vitro assays for drug leads. Main products/instrumentation under R&D: Small molecular drug candidates.

920 DHARMACON RESEARCH, INC. Add: 3200 Valmont Road, #5 Boulder, CO 80301 Tel: (303) 415-9880 Fax: (303) 415-9897 E-mail: [email protected]

921 DIABEX, INC. Add: 24-62 Scurfield Blvd. Winnipeg, Manitoba R34 IMS Canada Tel: (204) 487-2328 Fax: (204) 488-9823 E-mail: [email protected] E-mail: [email protected] Web site: www.diabex.com President/CEO: Albert D. Friesen Research director: Wayne Lawtt R&D expertise: Development, research and discovery of treatments for Type II diabetes. Technological expertise: SM C, C/TC, D-D Main products/instrumentation under R&D: Diabetes therapeutics for treatment of Type II diabetes; muscarinic receptor antagonists. Sealed and granted patents: Mechanisms and compounds related to Type II diabetes and its treatment; method for treating, controlling, and preventing diabetes mellitus, 6,555,126, U.S.

Web site: www.dharmacon.com President: Stephen Scaringe, Ph.D. R&D expertise: Development and manufacture of RNA oligonudeotide synthesis. Technological expertise: SY, CSDP, CW Principal products/instrumentation: Contract manufacturing products, RNA oligonucleotides, ACE. Main products/instrumentation under R&D: LGE cells, cellular therapy, to treat chronic intractable pain and stroke, Phase II; Neuro Cell-FE (cellular transplantation therapy), to treat focal epilepsy, Phase II; Neuro Cell-HD, cellular therapy, to treat Huntington’s disease, Phase II, 2008; Neuro cell-PD, to treat Parkison’s disease Phase III–IV, 2008; human hepatocytes, for treatment of chronic liver failure, phase II; porcine hepatocytes, acute liver failure, phase I; RNA oligonucleotide synthesis.

922 DIACRIN., INC. Add: Bldg. 96 13th St. Charlestown Navy Yard Charlestown, MA 02129 Tel: (617) 242-9100 Fax: (617) 242-0070 Web site: www.diacrin.com President/CEO: Thomas H. Fraser, Ph.D. Research director: Jonathan Dinsmore, Ph.D. R&D expertise: Research, development and production of biotechnology medicines and vaccines to treat human diseases caused by cell dysfunction or cell death. Joint ventures: Diacrin/Genzyme LLC; 50/50 JV. R&D collaboration: Massachusetts General Hospital, McLeans Hospital.

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Technological expertise: P/S, H/CF, C/TC, CH/S

Technological expertise: BI, BS, GA, GT, G, PG, RD, Q, TE, T

Principal products/instrumentation: NeuroCell for treatment of Parkinson’s disease (PD), NeuroCell for treatment of Huntington’s disease (HD), NeuroCell for treatment of focal epilepsy (FE), NeuroCell for treatment of cognitive disorders (CD), HepatoCell and CardioCell.

Main products/instrumentation under R&D: Diagnostics reagents, vaccines, antibodies.

Main products/instrumentation under R&D: LGE cells, cell therapy to treat chronic refractory pains, Phase I/II; NeuroCell-FE (cellular transplantation therapy) for epilepsy, Phase I; NeuroCell-HD (cellular transplantation therapy) for treatment of Huntington’s disease, Phase II; NeuroCell-PD (cellular transplantation therapy) for treatment of Parkinson’s disease, Phase III/IV; Human hepatocytes, cell therapy, for chronic hepatic failure, Phase II; Procine hepatocytes, cell therapy for acute hepatic failure. Vaccines, other biotechnology medicines. Sealed and granted patents: Methods for storing neural cells such that they are suitable for transplantation. 6,713,245, U.S. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function. 6,491,912, U.S.; Transplantation of neural cells for the treatment of chronic pain or spasticity. 6,444,205, U.S.; Muscle cells and their use in cardiac repair. 6,673,604, U.S.

923 DIAGAID DIAGNOSTICS PVT, LTD.

924 DIAGNON CORP. Add: 9600 Medical Center Dr. Rockville, MD 20850 Tel: (301) 251-2801 Fax: (301) 251-1260 President/CEO: John C. Landon, Ph.D. Research director: Anthony R. Welch, Ph.D. R&D expertise: Contract research and development for the NIH veterinary products. R&D collaboration: USUHS, NIDDK. Key sales market contracts: Butler. Technological expertise: T Principal products/instrumentation: Contract research/clinical trial products, veterinary vaccines, equine IgG, Lyphomune. Main products/instrumentation under R&D: NIH veterinary products. Sealed and granted patents: Nonhuman primate caging.

925 DIAGNOSTIC BIOSYSTEMS Add: 1020 Serpentine Lane, Ste. 111 Pleasanton, CA 94566

Add: 30-B Dhyan Singh Complex Near Bus Stand Ludhiana, Punjab 141002 India

Tel: (925) 484-3350

Tel: (91) 161-447-187

President/CEO: Bipin Gupta

Fax: (91) 161-449-609

R&D expertise: Immunoreagents design and manufacture for R&D application.

E-mail: [email protected] CEO: Davinderpal S. Bhatia R&D expertise: Medical diagnostics development and manufacture.

Fax: (925) 484-3390

Key sales market contracts: MAASI; Matritech, Inc.; CMB-Tech. Technological expertise: PA, C/TC, H/CF

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Principal products/instrumentation: PanStabilizer, PanVirocide, SlideMaster, CC/Mount. Main products/instrumentation under R&D: Immunoreagents.

926 DIAGNOSTIC CHEMICALS LIMITED

566-1396, Fax: (902) 566-2498; 160 Christian Street, Oxford, CT, USA 06478.

927 DIAGNOSTIC HYBRIDS, INC. Add: One President St. Athens, OH 45701 Tel: (614) 593-1784 Fax: (614) 593-0980

Add: 16 McCarvilleSt. Charlottetown, PEI CIE 2A6 Canada Tel: (902) 566-1396

President: Dr. David Scholl, Ph.D. Research director: Jim Brown

E-mail: [email protected]

R&D expertise: Development of in vitro diagnostics, bioprocess engineering products, cell and tissue culture.

Web site: www.dclchem.com

Scale-up partners: BioWhittake, Inc.

Add: 160 Christian St. Oxford, CT 06478 Tel: (203) 881-2020; (800) 325-2436

Joint ventures: BioWhittake for sale and distribution of Elvis technology.

Fax: (203) 888-1143

R&D collaboration: BioWhittaker.

E-mail: [email protected]

Key license and trade contracts: Washington University, Case Western University.

Fax: (902) 566-2498

Web site: www.dclchem.com President: Dr. J. Regis Duffy, Ph.D. Research director: Dr. Gary Reid, Ph.D. R&D expertise: Bioprocess engineering products development of stock and custom made enzymes and specialty chemicals for use in the biotechnology industry. Technological expertise: CC, LP, E, P/S, SY, CB, SMC, BI, OC, organic chemical synthesis. Principal products/instrumentation: Contract research/clinical trial products, natural products, nutraceuticals, reagents, veterinary vaccines, dithrothreitol (DTT); 5-Fluorotic acid, (5-70A); Isoporayl-B-D thiogalac-topyranosins DioxaneFree-IPTG; 5-Bromo-4-Chloro-3-IndoM-bD-Galactopygenosis-De, (X-Gal). Specialty chemicals, enzymes.

Technological expertise: T, C/TC Principal products/instrumentation: Genetically engineered cell culture for assay, Hybriwix; Elvis HSV detection; Fresh Cells; Fresh Frozen Cells, Elvis Gold; Diagnostic kit. DNA probe test for herpes identification, prepared cell cultures for clinical virology in plates, high density frozen cell concentrates, antiviral susceptibility test kits for drug resistance and drug screening application, contract cell culture manufacturing. Main products/instrumentation under R&D: Elvis typing, Elvira — antiviral susceptibility testing. Sealed and granted patents: Elvis technology, Sindbis Detection.

Main products/instrumentation under R&D: Stock and custom made enzymes.

928 DIAGNOSTICS LONGWOOD, S.L.

Subsidiary bodies: Diagnostic Chemicals Limited, West Royalty Industrial Park, Charlottetown, P.E.I., CIE 2A6, Canada, Tel: (902)

Add: Ctra. Madrid, KM 315,8 Edlf. ficpozaragosa. Of. 2B Zaragoza 50012 Spain Tel: (34) 976-320638

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Fax: (34) 976-320660 E-mail: [email protected] President/CEO: Antonio Raichs R&D expertise: Development and manufacture of in vitro diagnostics: histocompatibility (tissue typing), cryopreservation, other biopharmaceuticals R&D.

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Main products/instrumentation under R&D: MDA LDL Test Kit, developmental stage; food contamination analysis, medical diagnostic kits.

930 DIAGNOSTIC SYSTEMS LABORATORIES, INC.

Joint ventures: GEN TRAK, INC (USA): histocompatibility serology products.

Add: 445 Medical Center Blvd. Webster, TX 77598

Technological expertise: C/TC, E, COC

Tel: (281) 332-9678

Principal products/instrumentation: Rabbit complement, DLBITT.

Fax: (281) 338-1895

Main products/instrumentation under R&D: One-step rapid assays, histocompatibility serology products, cryopreservation.

Web site: www.dslabs.com

929 DIAGNOSTIC SPECIALTIES

E-mail: [email protected] President/CEO: Gopal Sayjani Research director: Jehangir Mistry, Ph.D. R&D expertise: Development and manufacture of immunodiagnostic test kits. Technological expertise: E, DK

Add: 4 Leonard St. Metuchen, NJ 08840 Tel: (732) 549-4011 Fax: (732) 549-4711 E-mail: [email protected] Web site: www.earthlink.net/~cthak President/CEO: Praful K. Raja

Principal products/instrumentation: Growth factors, Antigens, Bonemarkers. Main products/instrumentation under R&D: Immunodiagnositc test kits. Sealed and granted patents: U.S. 5,935,775; U.S. 5,747,273; U.S. 6,066,464.

Research director: Rinaldo Pagnucco, Ph.D. 931 DIAGNOSTICUM, LTD.

R&D expertise: R&D and manufacture of medical diagnostic kits (OEM and DS); food contamination analysis; contract R&D for the healthcare and pharmaceutical sectors, related novel products manufacture.

Add: Attila Ut 126 Budapest 1047 Hungary

R&D collaboration: Johnson & Johnson, Bard Diagnostic Sciences, Inc., Rutgers University.

E-mail: [email protected]

Technological expertise: E, PA, P/S, BA, H/CF

President/CEO: Ferenc Peterfy, Ph.D.

Principal products/instrumentation: Contract manufacturing products, research/clinical trial products, EnZIP Microalbumin Test Kits, Pregna Cert Latex Pregnancy Kit, EnZIP Fibrinogen Test Kit, EnZIP Immunoturbidimetric Urinary Albumin Kit, Cholesterol/HDL, Glucose, Potassium, Hemoglobin Test Kits, PSA Elisa Kit.

Research director: Klara Rasky, Ph.D.

Tel: (36) 1-369-0739 Fax: (36) 1-369-4383 Web site: www.diagnostioim.hu

R&D expertise: Development and manufacture of diagnostics for human and veterinary disease labs. Technological expertise: H/CF, DK Principal products/instrumentation: Gliatest, Mygatest, AlleN-E, AlleN-G, MySytest.

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Main products/instrumentation under R&D: Diagnostics for food allergy; poultry serology, diagnostics for human and veterinary disease.

Principal products/instrumentation: K-Dtect, Kwik-Dtect, ShrimProbe. Main products/instrumentation under R&D: Healthcare products for the aquaculture.

932 DIAGNOSTIX, LTD. 934 DIATIDE, INC. Add: 400 Matheson Blvd. E. Unit 14 & 15 Mississauga, Ontario L42 1N8 Canada

Add: 9 Delta Dr. Londonderry, NH 03053

Tel: (905) 890-6023

Tel: (603) 437-8970

Fax: (905) 890-6024

Fax: (603) 437-8977

Web site: www.diagnostix.com

Web site: www.diatide.com

President/CEO: Howard Lee

E-mail: [email protected]

R&D expertise: R&D of immunoassay tests, on-site tests for drugs of abuse and environmental contaminants.

Presidentf/CEO: Richard T. Dean, Ph.D.

Key sales market contracts: Editek. Technological expertise: E, CH/S, DK Principal products/instrumentation: EZ screen profile; Verdict; EZ screen breath alcohol tubes, QED saliva alcohol test. Main products/instrumentation under R&D: Immunoassay tests, on-site tests for drugs of abuse.

933 DIAGXOTICS, INC. Add: 27 Cannon Rd. Wilton, CT 06897 Tel: (203) 762-0279 Fax: (203) 762-2378 E-mail: [email protected] Web site: www.diagxotics.com President/CEO: John J. Reddington R&D expertise: Development and manufacture of healthcare products for the aquaculture and veterinary industries. R&D collaboration: Alpharma. Key sales market contracts: Diagnostic Chemicals Ltd. Technological expertise: RD, H/CF

Research director: John Lister-James, Ph.D. R&D expertise: Research and developing of peptides for therapeutics and in vivo diagnostic use, peptide instrumentation. R&D collaboration: Brookhaven National Laboratory, Nycomed. Key sales market contracts: Nycomed Amersham. Technological expertise: SY, CS, PIS, P, PI, PS/AP, PPAT, P/PS Principal products/instrumentation: ACUTECT for treatment of thrombosis, infection, bone cancer pain, atherosclerosis; P280-for GP IIB/IIIA receptor, stain receptor, P748 for GPII 483H white blood cells. Main products/instrumentation under R&D: Techtide (p-483H), for detection inflammatory processes, Phase II completed in 2008; Neo Tide P-2045 for inhibition of tumor growth; Phase I/II, 2008; Stanamet Sn-117m DTPA for treatment of pain of tumor bone metastasis, Phase III; Acu Tec Tc-99m apcitide for detection of carotid thromobosis, Phase III.

935 DIATOME U.S. Add: 321 Morris Rd. P.O. Box 125 Fort Washington, PA 19034

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Tel: (215) 646-1478

Fax: (301) 680-0696

Fax: (215) 646-8931

E-mail: [email protected]

E-mail: [email protected]

Web site: www.digene.com

Web site: www.emsdiasum.com

President/CEO: Evan Jones

President/CEO: Stade Kirsch

Research director: Attila Lorincz

Research director: Helmut Gnaegi

R&D expertise: Research, development, manufacture and marketing of diagnostic kits to detect human disease.

R&D expertise: Development and manufacture of diamond knives for cutting of biological samples. Technological expertise: CB, BTS, COC Principal products/instrumentation: Diatome™ Diamond Knives; Static-Line Ionizing Unit, biological samples.

936 DIAZEM CORPORATION

Technological expertise: RD, GA, C/TC Principal products/instrumentation: Hybrid Capture System; SHARP Signal System; Hybridization-Grade Reagents. Main products/instrumentation under R&D: Diagnostic kits to detect human diseases. Subsidiary bodies: Digene Corp., 9000 Virginia Manor Rd., Suite 206, Beltsville, MD 20705.

Add: 1406 E. Pine St. Midland, MI 48640 Tel: (517) 832-3612 Fax: (517) 832-8753 President: Melvin Cabey Research director: Dr. Anthony Revis

938 DIGITAL GENE TECHNOLOGIES, INC. Add: 11149 North Torrey Pines Rd. La Jolla, CA 92037

R&D expertise: Development and manufacture of separations media.

Tel: (858) 552-1400

Key sales market contracts: Diazem products are available through MetaChem Technologies, Inc., an exclusive distributor.

E-mail: [email protected]

Key license and trade contracts: Diazem Corporation is the exclusive licensee of 12 patents in fundamental silane and surface science from Dow Coming Co. Technological expertise: CC, P/S, PIS Principal products/instrumentation: HPLC Columns and accessories; Sample dean cartridges. Main products/instrumentation under R&D: Separations media, Diazem products.

937 DIGENE CORPORATION Add: 9000 Virginia Manor Rd. Beltsville, MD 20705

Fax: (858) 552-8625 Web site: www.dgt.com President/CEO: Robert J., Sutdiffe Research director: Karl W. Hasei, Ph.D.; Brian Hilbush, Ph.D. R&D expertise: Genomic Bioinformatics research of involved total gene expression comparison and analysis, tissue assays, database access and new gene discovery; related products development and manufacture. R&D collaboration: The Scripps Research Institute, Recordation, Immunex, Elan, and 22 academic research collaborations. Key license and trade contracts: The Scripps Research Institute. Technological expertise: RD, R, Q, BI, C/TC, CH/S, GA

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Principal products/instrumentation: New gene, gene isolation and expression method.

E-mail: [email protected]

Main products/instrumentation under R&D: Genomic bioformatics, total gene expression comparison and analysis, tissue assays, new gene discovery technologies.

President/CEO: Virgil Evings

Sealed and granted patents: Gene Isolation and Gene Expression Patents licensed from The Scripps Research Institute and J. Gregor Sutdiffe, Ph.D.

939 DIGITAL IMAGERS Add: 08924 Northern View Elbum, IL 60119 Tel: (630) 365-5332

Web site: www.di.com Research director: Mark Rodgers R&D expertise: Development and manufacture of scanning probe microscopes and atomic force microscopes. Technological expertise: BME, BA Principal products/instrumentation: BioScope™ atomic force microscope, Dimension series scanning probe microscopes and Multimode scanning probe microscope. Main products/instrumentation under R&D: New scanning prove microscopes and atomic force microscopes.

Fax: (630) 365-5332 E-mail: [email protected] Web site: www.dipms.com

941 3-DIMENSIONAL PHARMACEUTICALS, INC.

President: Charles Parzick Research director: C. Parzick R&D expertise: Development and manufacture of new washing, dispensing and imaging products for biotech R&D use of microplates; manufacture of microplate washers for filter and solid-bottom traps and imaging systems. Technological expertise: HTDS, BME Principal products/instrumentation: Synthesis instruments, flow-through plate microwasher 96 and 384; Imaging systems — gel and microscope; vacuum traps — 10 and 20L, microplate washers for filter. Main products/instrumentation under R&D: Big bore plate washer for solids removal, new washing, dispensing and imaging products.

940 DIGITAL INSTRUMENTS Add: 112 Robin Hill Rd. Santa Barbara, CA 93117 Tel: (805) 899-3380; (800) 873-9750 Fax: (805) 899-3392

Add: 665 Stockton Dr. Suite 104 Extern, PA 19341 Tel: (610) 458-8959 Fax: (610) 458-8258 Web site: www.3dp.com President/CEO: Thomas Stagnaro Research director: F. Raymond Salemme R&D expertise: Development and research of small molecule pharmaceuticals using crystallography, combinatorial chemistry and structure based drug design. R&D collaboration: Wyeth, Merck KGaA, Viropharma, Heska. Technological expertise: C/TC, COC, CH/S, D-D, E, HTDS, R, SMC Principal products/instrumentation: Small molecule pharmaceuticals, combinatorial chemistry library. Sealed and granted patents: Directed diversity, Combinatorial chemistry, Thermo FluoR (2001). Analogs of human basic fibroblast growth factor mutated at one or more of the

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positions glutamute 89, aspartate 101 or leucine 137. 6,274,712, U.S.; 6,770,485, U.S.; 6,767,722, U.S.; Methods of using analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamate 89, asparate 101 or leucine 137. 7,138,374, 6,737,404, U.S.; others pending.

942 DIONEX CORP.

291

Main products/instrumentation under R&D: Active pharmaceutical ingredients, related intermediates.

944 DIOSYNTH, INC. Add: 2136 S. Wolf Road Des Plaines, IL 60018 Tel: (847) 635-0985

Add: 1228 Titan Way, 501 Mercury Drive Sunnyvale, CA 94086-85

Fax: (847) 635-1320

Tel: (408) 737-0700

President: Geri Roman

Fax: (408) 733-3358

Subsidiary of AKZO Nobel (Diosynth B.V.)

President: A. Blaine Bowman

R&D expertise: Development and manufacture of active pharmaceutical ingredients.

Research director: Nebojsa Avdalovic R&D expertise: Research of separations technologies, novel products development. Technological expertise: P/S, CH/S, CB, PMC Principal products/instrumentation: Microfraction in LC and LC/MS, 2007. Main products/instrumentation under R&D: Drug separation technologies.

E-mail: [email protected]

Technological expertise: PIS, SY, P, PS, PI, P/PS Principal products/instrumentation: Contract manufacturing products, steroids, peptides, other biotechnology medicines. Main products/instrumentation under R&D: Active pharmaceutical ingredients.

945 DIRECT THERAPEUTICS, INC. 943 DIOSYNTH Add: Molenweg 50 OSS 5439 TB Netherlands Tel: (31) 412-661-333 Fax: (31) 412-662-521 E-mail: [email protected] Web site: www.akzonobel.com/di/home.htm President: Johan Evers Research director: Frans van Houpenhoven R&D expertise: Research, development and manufacturing of active pharmaceutical ingredients and related intermediates. Technological expertise: F, PA, CN, C/TC, PIS, P/S, SY Principal products/instrumentation: Contract manufacturing products, biopharmaceuticals.

Add: 2 Gannett Dr. Suite 200 White Plains, NY 10604 Tel: (914) 696-7700 Fax: (914) 696-7701 E-mail: [email protected] President: Richard Kronenthal, Ph.D. Research director: Dennis Pietronigro, Ph.D. R&D expertise: Development and manufacture of innovative pharmaceutical products for the treatment of solid malignant tumors. Technological expertise: DD, D-D Main products/instrumentation under R&D: Lead drug product, DTI-015, Phase II/III clinical trial; DTI-136, Phase I/II, innovative pharmaceutical products for the treatment of solid malignant tumors.

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Sealed and granted patents: U.S. #5,162,115, Antineoplastic solutions & method for treating neoplasms; U.S. #5,051,257 antineoplastic solution and method for treating neoplasms.

948 DISCOVERY TECHNOLOGIES, LTD. Add: Gewerbestrasse 16 Atlschwil CH-4123 Switzerland Tel: (41) 614-878-585

946 DISCOVERY DIAGNOSTICS

Fax: (41) 614-878-599

Add: P.O. Box 5186 Claremont, Ontario L1Y 1A4 Canada

E-mail: [email protected]

Tel: (905) 319-0070

CEO: Henri Zinzli

Fax: (905) 319-0012

Research director: Bernhard Schnurr

E-mail: [email protected] President: Leigh Becker

Subsidiary of Discovery Partners International

R&D expertise: Diagnostics development and manufacture.

R&D expertise: Drug discovery, design and development.

Technological expertise: AF, BS

Technological expertise: DDI, D-D, DD

Principal products/instrumentation: Wescor Macroduct, diagnostics, antibodies, enzymes.

947 DISCOVERY PARTNERS INTERNATIONAL Add: 9640 Towne Centre Drive San Diego, CA 92121

Web site: www.discovery-tech.com

Main products/instrumentation under R&D: New technology of drug discovery, novel drug. Subsidiary bodies: San Diego.

949 DISPOSABLE PRODUCTSSARSTEDT AUSTRALIA

Tel: (858) 455-8600 Fax: (858) 546-3081 E-mail: [email protected]

Add: 16 Park Way Technology Park Adelaide, South Australia 5095 Australia

Web site: www.discoverypartners.com

Tel: (61) 8-8349-6555

President/CEO: Riccardo Pigliucci

Fax: (61) 8-8349-6882

Research director: John Lillig

R&D expertise: Development and manufacture of professional instruments and disposables for science and medicine.

R&D expertise: New technology development, products manufacture and services for drug discovery. Principal products/instrumentation: Biopharmaceuticals, contract R&D products.

Technological expertise: C/TC, BME, BS

Main products/instrumentation under R&D: New technology of drug discovery.

Principal products/instrumentation: SafetyMonovette blood collection; Cell  and tissue culture system; Biosphere PCR range.

Sealed and granted patents: Remotely programmable matrices with memories, 6,372,428, U.S.

Main products/instrumentation under R&D: Professional instruments: Cell sorter, tissue grinder.

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950 DIVERSA CORPORATION

293

R&D collaboration: Ischemia Technologies, Inc.

Add: 10665 Sorrento Valley Road San Diego, CA 92121

Technological expertise: BI, C/TC, CH/S, DD, HTDS, PIS, P/S, SMC, SY, Q

Tel: (619) 453-7020

Principal products/instrumentation: In vitro toxicology testing products, yeast test, 2000; DermaDex.

Fax: (619) 453-7032 E-mail: [email protected] Web site: www.diversa.com President: Jay M. Short, Ph.D. R&D expertise: Discovery, modification, manufacture and commercialization of new protein-based biocatalysts and enzyme additives for chemical, biopharmaceutical, agricultural and industrial customers. Joint ventures: BioDiversity access agreements: Costa Rica, Iceland, Indonesia and Yellowstone National Park. R&D collaboration: The Dow Chemical Company. Technological expertise: E, Q, SMC, HTDS, R, DD, DK Principal products/instrumentation: Library screening kits, Clonezyme™. Main products/instrumentation under R&D: New protein-based biocatalysts, enzyme additives.

951 DMI BIOSCIENCES, INC. Add: 3601 S. Clarkson St., #420 Englewood, CO80110 Tel: (303) 789-1929 Fax: (303) 789-0510

Main products/instrumentation under R&D: Therapeutics for: cardiovascular ischemia/ reperfusion, preclinical; Cerebrovascular Ischemia/reperfusion, preclinical; Oxidative stress, preclinical; Alzheimer’s disease, preclinical; Appendicitis Diagnostic — FDA submission; Yeast Test — FDA approved. Sealed and granted patents: Numerous.

952 DNA INTERNATIONAL, INC. Add: PMB 151,333 S. State St. Lake Oswego, OR 97034 Tel: (800) 990-8322 Fax: (800) 997-8322 President: R. Walker R&D expertise: Development and manufacture of synthetic oligos, DNA with modifications, gel purification and HPLC purification phosphorothioate oligos. Technological expertise: P/S, SY, CPHC, DKHC Principal products/instrumentation: Biologicals, contract manufacturing products. Main products/instrumentation under R&D: Synthetic oligos, DNA with modifications, HPLC purification phosphorothioate oligos.

E-mail: [email protected] Web site: www.dmibio.com President/CEO: Bruce G. Miller Research director: David Bar-Or R&D expertise: Development and manufacture of biopharmaceuticals.

953 DNAMP, LTD. Add: Suite 5, St. Albans House 40 Lynchford Road Farnborough, Hants GU14 6EF UK Tel: (44) 0 1252-376288

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Fax: (44) 0 870-1640-382

Tel: (301) 990-4090; S00-998-3628

E-mail: [email protected]

Fax: (301) 990-4063

Web site: www.dnamp.com

E-mail: [email protected]

President/CEO: Dr. D. Clark

President: Javed Z. Siddiqi, Ph.D.

Research director: Dr. D. Clark

Research director: Javed Z. Siddiqi, Ph.D.

R&D expertise: Development and manufacture of enzymes and reagents for PCR applications.

R&D expertise: Custom research of molecular biology, kits and enzymes; biotechnology engineering products.

Technological expertise: F, Q, GA, P/S, RD, E, ET Principal products/instrumentation: Accurase Long PCR Enzyme, Calypso RT-PCR System; DCode Cycle Sequencing System, TAQ Polymerase. Main products/instrumentation under R&D: Enzymes and reagents for PCR.

954 DNASTAR, INC. Add: 1228 S. Park St. 3801 Regent st. Madison, WT 53715, 53, 705 Tel: (608) 258-7420

Key sales market contracts: Cosmo Bio Co., Ltd., Japan; AMS Biotechnology, Ltd., UK; Fujisawa, Ltd., Japan. Technological expertise: PA, Q, F, LP, C/TC, P/S, RD, GA Principal products/instrumentation: Super Ampicillin; Super Hybridization Buffer System; Super Immunoblotting System; SuperClean Miniprep System; Ultra DNA Fectomine; Super Aceyl Agarose; Ultra Competent and Ultra Electrocompetent Cells; Super Lambda markers; Ready Western Single/Multiple Tissue Blots; GeneQuest™ System; ChemGlow DNA Detection System.

Fax: (608) 258-7439 E-mail: [email protected] Web site: www.dnastar.com

956 DNATOOLS

President/CEO: Fred Blattner, Ph.D.

Add: P.O. Box 272531 Ft. Collins, CO 80527

Research director: John Schroeder, Ph.D.

Tel: (970) 689-9268

R&D expertise: Biotechnology software development and related equipment manufacture for DNA analysis.

Fax: (970) 226-8723

Technological expertise: CH/S, BME, GA, G Principal products/instrumentation: Lasergene for Mac and IBM; Gene-expression software, 2007. Main products/instrumentation under R&D: Biotechnology software, DNA analysis devices.

955 DNA TECHNOLOGIES, INC. Add: 7860 Beechcraft Ave. Gaithersburg, MD 20879

E-mail: [email protected] Web site: www.dnatools.com President/CEO: Jerry Tuneberg R&D expertise: Development of biotechnology software, web-based bioinformatics solutions for DNA, EST, and protein research. Technological expertise: BI, P/PS, PS/AP, RD, PC Principal products/instrumentation: dnaLIMS™, a web-based bioinformatics solution for processing DNA sequencing requests, DNA LIMD.

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Main products/instrumentation under R&D: Protein LIMS, biotechnology software web.

295

Tel: (781) 778-3700 Fax: (781) 778-3800 Web site: www.domainpharma.com

957 DNX CORP.

President/CEO: Philip Lee Research director: Webb Stacy

Add: 5 Cedar Brook Rd. Cranbury, NJ 08512 Tel: (908) 722-7900 Fax: (908) 722-6677

R&D expertise: Biotechnology software development and manufacture.

E-mail: [email protected]

Key sales market contracts: Alliance with CSC Healthcare.

Web site: www.dnxtrans.com

Technological expertise: CH/S

President/CEO: Paul Schmitt

Principal products/instrumentation: Research/ clinical trials products, Clintrial, Clintrace, Presidio RDC, Integrated Review.

R&D expertise: Research of transgenic animal technology, drug preoducts development services; Contract research. Joint ventures: Nextran (with Baxter Healthcare), organ transplant products. R&D collaboration: Baxter Healthcare, Nextran.

Main products/instrumentation under R&D: Biotechnology software. Subsidiary bodies: Sunnyvale, CA; Australia, England, France, Germany, Japan.

Key license and trade contracts: Ohio University, microinjection. Technological expertise: T, OC, TE Principal products/instrumentation: Organ transplants/culture, contract research products, Biodigm-IGT, transgenic mouse model of Type II (noninsulin-dependent) diabetes, introduced in May; Biodigm CETP, CETP inhibition; Biodigm ApoB, LDL reduction; Biodigm CETP/ApoB, human cholesterol distribution; Biodigm ApoE3 and Biodigm CETP/Apo3, Type III hyperlipoproteinemia; Biodigm PCA2, inflammation. Main products/instrumentation under R&D: Organ transplantation through Nextran, transgenic animal technology.

959 DOME PHARMA INDUSTRIES Add: Biopole Clermont-Limagne Rond point du Biopole, Puy-de-Dome Saint Beauzire, Cedex F-63360 France Tel: (33) 7364-4343 Fax: (33) 7364-4344 President: D. Paulet R&D expertise: R&D and scale-up production of drugs, cosmetics and veterinary products.

Subsidiary bodies: Pharmakon Research International, Waverly, PA and Lyon, France.

Joint ventures: Dome Pharma industries, a member of an association of economic interests of biotechnology companies; OCTOTECH GIE, which are set up in a Science Pare (a Technopole); the Biopole Clermont-Limagne.

Sealed and granted patents: #4,873,191.

Technological expertise: D-D, DD

958 DOMAIN PHARMA CORPORATION Add: l0 Maguire Rd. Lexington, MA 02421

Principal products/instrumentation: Cosmetics, veterinary vaccines. Main products/instrumentation under R&D: Antibodies, reagents, other biotechnology medicines.

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960 DOMINION BIOSCIENCES, INC. Add: Virginia Tech Corporate Research Center Suite 1600, 1872 Pratt Dr. Blacksburg, VA 24060 Tel: (540) 961-5319 Fax: (540) 961-2112 E-mail: [email protected] Web site: www.dominionbio.com

R&D expertise: Research of gas and liquid purification, related applied products manufacture. Technological expertise: F, P/S Principal products/instrumentation: Foam separator for fermentation (Turbosep); Sterile air/gas filters, High Flow Tetpor; Liquid sterilizing and clarifying filters, Propor/Peplyn. Main products/instrumentation under R&D: Gas and liquid purification technologies.

President/CEO: E. B. (Steve) Banegas Research director: Joseph Faikinham III, Ph.D. R&D expertise: Development, manufacture and commercialization of biopesticide products, bioremediation agents and environmental tests. Joint ventures: Synthons, Inc. — manufacturer. Key license and trade contracts: Virginia Center for Innovative Technology, Virginia Tech University, Pennsylvania State University.

962 DONGILBIOTECH Add: 2F Daesan B/D, 234-9 Poi-dong, Kangnam-ku Seoul 135-260 Korea Tel: (82) 2-571-3790 Fax: (82) 2-571-3792 President: M. H. You R&D expertise: Biotech drugs production and supply.

Technological expertise: F, E, D-D, P/S, BA, C/TC, CH/S

Technological expertise: PA, E, BA, F, TE, PG, GT, H/CF

Main products/instrumentation under R&D: Biopesticides, bioremediation, diagnostics, Ecologix Insect Growth Regulators, Ecologix™ Cockroach Bait, LEONE™ Biofungicide, LEONE™ Antimicrobial Agents, Coliphage Virus test, bioremediation.

Principal products/instrumentation: Detergents, organ transplants/culture, biologicals, diagnostics, pharmaceuticals, plastics, process validation, chemicals products, instrumentation, contract manufacturing products, in vitro toxicology testing, contract research/clinical trials products.

961 DOMNICK HUNTER, INC. Add: 5900 Northwoods Pkwy. Charlotte, NC 28269 Tel: (704) 921-9303

Main products/instrumentation under R&D: Other biotech drugs.

963 DOUBLETWIST, INC.

Fax: (704) 921-1960

Add: 1999 Harrison St. 11th Floor, Ste. 1100 Oakland, CA 94612

E-mail: [email protected]

Tel: (510) 628-0100

Web site: www.domnickhunter.com

Fax: (510) 628-0HI

President: Chris Churchill

E-mail: [email protected]

Subsidiary of The Domnick Hunter Group

Web site: www.doubletwist.com

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President/CEO: John Couch Research director: Nick Tsinoveamas R&D expertise: Research and development of bioinformatics, related novel products manufacture. Joint ventures: Myriad Genetics, Derwent, Proteome, Inc., AlphaGene, EraGen Biosciences, Chemdex — Ventro Life Sciences Company, BioTools Incorporated, ClonTech Laboratories, Inc., Molecular Simulations, Inc., Invitrogen, Sun Microsystems, StockPoint Technological expertise: HTDS, CH/S Principal products/instrumentation: Doublet twist clonTech, Prophecy — DoubleTwist’s exclusive annotated Human Genome Database; GeneForest — DoubleTwist’s exclusive annotated Human Gene Index and associated data mining and visualization tools; Clustering and Alignment Tool (CAT). Main products/instrumentation under R&D: Molecular biology manufacturing system, bioinformatics products.

964 DOVETAIL TECHNOLOGIES, INC. Add: 387 Technology Dr. College Park, MD 20742

297

Main products/instrumentation under R&D: Betathirte for cancer treatment, preclinical. Sealed and granted patents: 72 patents held.

965 DOW AGROSCIENCES CANADA, INC. Add: 1144 29 Av., NE, Ste. 201 Calgary, Alberta T2E 7P1 Canada Tel: (403) 735-8800 Fax: (403) 735-8817 President: Rick Smith Research director: Pete Desai R&D expertise: Molecular biology research of pest and agricultural crops. Research is aimed to optimize crops biological activity and to develop value-added crop products through biotechnology; Crop Protection, canola and corn seed and novel products breeding. Principal products/instrumentation: Pest management products and value-added agricultural products for crop protection seed and Nexara canola, Mycogen corn; agchem products of cereals. Sealed and granted patents: Xenorhabdus TC gene for pest control, 7,071,386, U.S.

Tel: (301) 405-0608 Fax: (301) 405-9187 E-mail: [email protected]

966 D-PHARM, LTD.

Web site: www.dovetailtech.org

Add: P.O. Box 2313 Kiryat Weizman Science Park Rehovot 76123 Israel

President/CEO: Floyd Taub, M.D.

Tel: (972) 8-930-0794

Research director: Floyd Taub, M.D.

Fax: (972) 8-930-0795

R&D expertise: Therapeutical research of non-toxic cancer treatment, effective products manufacture.

E-mail: [email protected]

Key license and trade contracts: Lifetime Pharmaceuticals, Inc.

R&D expertise: Drug design and reengineering based on selective molecular activation and routing technologies (SMART), related products development and manufacture.

Technological expertise: C, D, SMC, C/TC, D-D

President/CEO: Dr. Alex Kozak Research director: Dr. Itzchak Angel

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Key license and trade contracts: Shire Pharmaceuticals Group. Technological expertise: SMC, DD, D-D, SY Main products/instrumentation under R&D: DP-VPA, for the treatment of epilepsy; incorporating D-Rap™ technology, entered Phase B clinical basis; DP-b99 for stroke and traumatic brain injury, Phase I, for this novel neuro-protective agent designed to control apoplotic processes; DP-71 for cancer, psoriasis and inflammatory disorders; DP-109 for neuro-degeneration, Parkinson’s and Alzheimer’s disease, an innovative membrane-activated cholator, suitable for oral, chronic administration, selective molecular activation and routing technologies. Subsidiary bodies: D-Pharm, U.S., Inc., Chapel Hill, North Carolina. Sealed and granted patents: Patent application Prodrugs with enhanced penetration into cells.

967 DRAEGER SAFETY, INC. Add: 101 Technology Dr. Pittsburgh, PA 15275 Tel: (412) 787-8383 Fax: (412) 787-2207 E-mail: [email protected] Web site: www.draeger.com President/CEO: Wes Kenneweg R&D expertise: Development of Safety-gas detection equipment and systems and respiratory protection program; related products manufacture. Technological expertise: BME, DMC Principal products/instrumentation: SCBA; Personal monitors, toxic waste processing system. Main products/instrumentation under R&D: Safety-gas detection equipment and respiratory protection program.

968 DRG INTERNATIONAL, INC. Add: 1167 U.S. Highway 22 Mountainside, NJ 07092 Tel: (908) 233-2075 Fax: (908) 233-0758 E-mail: [email protected] Web site: www.drgintl.com President/CEO: Cyril E. Geadntov, Ph.D. Research director: Dr. A. Janetzko R&D expertise: Development/manufacture/ marketing of immunoassays for R&D and clinical use. R&D collaboration: E. Mezck. Key sales market contracts: Ansys Diagnostics, Awareness Technology, Linco Research, IDL, CHROMagar, HUMAN AG. Technological expertise: E, F, PA, P/S, HTDS, C/TC, CH/S Principal products/instrumentation: In vitro toxicology testing method, TGF beta 1, Leptin, PAPP-A, DRG Aurica Diagnostics; TGF beta 2, Cortisol-Saliva Elisas, DRG Aurica Diagnostics; DRG Aurica Diagnostics. Main products/instrumentation under R&D: Antibodies, cell-lines, immunoassays for R&D and clinical. Subsidiary bodies: DRG Instruments GmbH, Marburg, Germany, Tel: (49) 6421-17000, Fax: (49) 6421-921100, Mr. Saenger, Dr. Roeder, E-mail: [email protected], www.drgdiagnostics.de; DRG Instruments GmbH, Berlin, Germany, Tel: (49)30-941-3161, Fax: (49) 30-94 632951, Mrs. Ute Jung; DRG-CR, Brno, Czech Republic, Tel/Fax: (420) 5-41235326, Dr. Pavel Giacintov, E-mail: drg-bmo@ login.cz; DRG-Elstim, Zagreb, Croatia, Tel/ Fax: (385) 1-611-4040, Mrs. Marina Martinov Matic; DRG MedTek Sp.z.o.o., Warsaw, Poland, Tel/Fax: (48) 22-8-450-193, Mrs. Grazyna Wendewska, E-mail: [email protected]; DRGMedTek-South Poland, Gliwice, Poland,

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cell phone: (48) 601-61-7700, Mr. Witold Jurkiewicz, E-mail: [email protected]; DRG TechSystems, Moscow, Russia, Tel: (7) 095-243-5621/243-5228, Fax: (7) 095-2439300, Mr. Dmitri Kekalo, E-mail: drgtech@ dol.ru; DRG Biomedical A/O, St. Petersburg, Russia, Tel: (7) 812-246-5693/246-5793, Fax: (7) 812-242-0047, Dr. G. Lebedev, E-mail: [email protected]

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fabrication for experimental use in animals, and later in humans. Subsidiary bodies: Mouse Research Facility at Little Silver Animal Hospital, Little Silver, N.J., under supervision of Richard Yacowitz, DVM. Sealed and granted patents: 3 U.S. and 1 Canadian; #4771660, #5054339, #5401242.

970 DRUG DISCOVERY, LTD. 969 DRUG DELIVERY DEVICES, INC. (ODD) Add: 221 Second Av. Piscataway, NJ 08854 Tel: (732) 356-9366

Add: Royal College Building 204 George Street Glasgow Gl 1XW UK Tel: (44) 141-548-4534 Fax: (44) 141-552-8376

Fax: (732) 271-8857

E-mail: [email protected]

E-mail: [email protected]

Web site: www.drugdiscovery.co.uk

President/CEO: Hal Yacowitz, Ph.D.

CEO: Dr. Alan Harvey

Research director: Hal Yacowitz, Ph.D.

Research director: Carol Clements

Subsidiary of H. Yacowitz & Co.

R&D expertise: Discovery of lead compounds for novel medicines from natural products, related novel products development and manufacture.

R&D expertise: Research, development and manufacture and license of intradermal multiple injection devices for vaccine and drug delivery. R&D collaboration: Drug-vaccine delivery alliance with Applied Science Inc., Cedarville, Ohio; manufacture. of carbon fiber materials. R8d3 collaboration with U.S. Army on DNA vaccine delivery. Key license and trade contracts: Licensed AIMS Inc to produce and sell specific skin implantation devices in the U.S., Canada, Europe and Japan. Technological expertise: AF, CH/S, DD, GT, C/TC Principal products/instrumentation: DDD#100 electro-mechanical, intradermal multiple injection device for vaccine and drug delivery in animals, DDD#100*. Main products/instrumentation under R&D: Self-vaccinating devices, disposable for DNA and microparticle-intradermal delivery;

R&D collaboration: TM Biosciences. Technological expertise: SMC, AF, C/TC, D-D, HTDS, P/S Main products/instrumentation under R&D: Anti-asthma, preclinical; Anti-ulcer, preclinical), In vitro toxicology testing, natural products, nutriceuticals, pesticides, pharmaceuticals, lead compounds for novel medicines.

971 DRUG ROYALTY CORPORATION, INC. Add: 8 King St. East, Suite 202 Toronto, Ontario M5C 1B5 Canada Tel: (416) 863-1865 Fax: (416) 863-5161 E-mail: [email protected]

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Web site: www.drugroyalty.com

Technological expertise: DD, D-D, DDI

President: James R. Webster

Principal products/instrumentation: Therapeutic drugs include CNS, cardiovascular, metabolic diseases, oncology, infectious diseases, and dermatologicals.

Research director: John McCulloch R&D expertise: Development of biopharmaceuticals in field for the life science industry, related applied products development and manufacture. Key license and trade contracts: Amgen Inc., UltraVision Inc., Phytogen Life Science Inc., University of Birmingham/Peptide Therapeutics Group, Cambridge Antibody Technology Group plc, Searle Canada, Spectral Diagnostics Inc., Paladin Labs Inc./Pharmasdence Inc.; Bristol-Myers Squibb Company. Technological expertise: BI, DD, GT, PIS, RD, COC, D-D, SMC, SY, G, PG

Main products/instrumentation under R&D: Drug metabolizing enzymes, drug delivery route.

973 DRY CREEK LABORATORIES Add: 1618 Baldwin Road Hughson, CA 95326-9699 Tel: (209) 581-9010 Fax: (209) 581-9014

Principal products/instrumentation: Neupogen for prevention of infections, specialty contact lenses products and lens products, pPaxil, Taxol, cardiac markers.

President/CEO: John A. Driver

Main products/instrumentation under R&D: Drug discovery technology, allergy vaccines, human monoclonal antibodies, cardiac markers; drugs for acute pain.

R&D collaboration: Monsanto Company.

Research director: Walter J. VTss R&D expertise: Horticulture: T. N. V. (Trees, Nuts, Vines), Key sales market contracts: Monsanto Company. Technological expertise: A, C, R, T

972 DRUG SAFETY EVALUATION CONSULTING, INC. Add: 441 Green Glade Rd. Birmingham, AL 35244-3223 Tel: (205) 995-9545 Fax: (205) 995-0419 E-mail: [email protected]

Principal products/instrumentation: Micropropagated tree rootstocks, Traedone. Main products/instrumentation under R&D: Transgenic fruit, nut trees, vines and grapevine crops, R&D, field trials.

974 DSM BIOLOGICS

Web site: www. dseconsulting.com

Add: Zuiderweg 72/2 P.O. Box 454 Groningen 9700 AL Netherlands

President: Duane B. Lakings, Ph.D.

Tel: (31) 50-5222-222

R&D expertise: Research of drug include bioanalytical and analytical chemistry, pharmacokinetics, drug metabolism and ADME (absorption, distribution, metabolism, excretion), and drug delivery and formulation stability, over 25 years of drug discovery and development experience.

Fax: (31) 50-5222-333 E-mail: [email protected] Web site: www.dsmbiologics.com President: Pieter Degeus Research director: Jos J. van Weperen

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R&D expertise: Contract development and bioprocess engineering products.

Tel: (610) 768-5886

Technological expertise: C, G, M, P, R, FLB

Web site: www.dsm-foodspecialties.com

Principal products/instrumentation: MAb, pDNA, Fab, proteins, vaccines, monoclonal antibodies.

President: Richard E. Calk, Jr.

Main products/instrumentation under R&D: Bioprocess engineering products. Subsidiary bodies: DSM Biologies, Montreal, Canada. Sealed and granted patents: K. Lactis.

975 DSM BIOLOGICS COMPANY, INC. Add: 600 Royalmount Avenue Montreal, Quebec H4P 2T1 Canada Tel: (514) 341-9940

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Fax: (610) 768-5163

Subsidiary of DSM N.V. R&D expertise: Development and manufacture of natural food ingredients. Technological expertise: F, E, ERT, ET, FE Principal products/instrumentation: Maxiren pure chymosin; Gistex; Maxarome; Delvocid; Delvotest; Klerzyme; Rapidase; Fromase. Main products/instrumentation under R&D: Natural food ingredients.

977 D-SQUARED BIOTECHNOLOGIES INCORPORATED

Fax: (514) 341-1227

Add: P.O. Box 78843 Adanta, GA 30357

E-mail: [email protected]

Tel: (404) 577-0919

Web site: www.dsmbiologics.com

Fax: (404) 577-0497

President/CEO: Jan Willem den Toom

Web site: www.dsbiotech.com

Research director: Martina Bielefeld-Sevigny

President/CEO: Dr. David L Scott, Jr.

Subsidiary of DSM Fine Chemicals

Research director: Dr. David L Scott, Jr.

R&D expertise: Contract development and manufacturing of biopharmaceutical.

R&D expertise: Research of agricultural diagnostics and antibacterial drug development and manufacture.

Technological expertise: F, PA, RD, C/TC, GT, PMC, P/S Principal products/instrumentation: Contract manufacturing products, biopharmaceuticals and plasmid DNA; continuous cell lines, mycoplas enzyme analysis, cell culturing, patent cytogenetic analysis, DNA fingerprint. Subsidiary bodies: DSM Biologics, Zuiderweg 97744 AP, The Netherlands, Tel: (31) 3150-5222-333.

976 DSM FOOD SPECIALTIES USA, INC. Add: 700 American Ave. King of Prussia, PA 19406-4031

Key sales market contracts: Agdia Incorporated. Key license and trade contracts: Agdia Incorporated. Technological expertise: PA, Q, SMC, AF, AB, BI, P/S, GA, RD, GT, H/CF, SY, COC, PIS, CH/S Principal products/instrumentation: DNASCREEN™, RNASCREEN™, DNA X-tract, RNA X-tract, Dnabsorb, Rrtab-sorb™; Trademarks of D-squared Biotechnologies, Inc. 1999, agriculture, biologicals, diagnostics, biosensors, vaccines. Main products/instrumentation under R&D: Improved formats for rapid and sensitive DNA/RNA testing.

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978 D-STAR INSTRUMENTS Add: 8424 Quarry Rd. Manassas, VA 20110 Tel: (703) 335-0770

the agri-science, biotech, pharma sectors, environment and healthcare management. Joint ventures: D-Meditis, Kiev, Ukraine; Dragon Trends, Guangzhou, China.

President/CEO: Donald Kenworthy

R&D collaboration: LIM Corporation, Vancouver, Canada; Wanglnfo, Palo Alto, CA, USA; Sun Microsystems Computer (no. 160902); Silicon Graphics Computer (no. DP3876).

Research director: Dennis Jansen

Key sales market contracts: Alpha Advertising.

R&D expertise: Development and manufacture of biotechnology software, HPLC detectors and systems.

Key license and trade contracts: Monsanto Company, St. Louis, MO, USA; Polyclinic of Radiation Registry, Kiev, Ukraine.

Joint ventures: Lab Apparatus.

Technological expertise: HTDS, BI, CH/S, D-D, G, PG

Fax: (703) 335-9952 E-mail: [email protected] Web site: www.D-Star.corn

Technological expertise: COC, CH/S, CPHC, DKHC, HC, FL Principal products/instrumentation: STARCHROM HPLC Management software, 2000 HPLC Detector; DRL-10 Fluorescence; DLC20 HPLC Systems, HPLC detectors and systems. Main products/instrumentation under R&D: Diode Array HPLC Detector; Retractive Index Detector, biotechnology software.

Principal products/instrumentation: UMICS — Universal Medical Information Computer Systems for healthcare; GeneFIND — discovery tools; Promoter-gene-finding tool; Simmotility — simulation tool for modeling separation of macromolecules; SimphoRseis — simulation tool for modeling separation of macro molecules; ChemoBase — an epidemiological database of radiation; ProClass — a database of protein superfamilies.

979 DTRENDS, INC. 980 DUKAS ASSOCIATES Add: 2570 San Ramon Valley Blvd, A203 San Ramon, CA 94583-1673

Add: 236 Payson Rd. Belmont, MA 02478

Tel: (925) 355-9180

Tel: (617) 484-9268

Fax: (925) 355-9182

Fax: (617) 484-8607

E-mail: [email protected]; hal@d-trends. com

E-mail: dukassoc@aol. com

Web site: www.d-trends.com President: Dr. Hwa A. Lim, Ph.D., M.B.A. (Acting) Research director: Dr. Hwa A. Lim, Ph.D., M.B.A. R&D expertise: Discovery research and development of information tools and infobases for

President/CEO: Theodore Dukas R&D expertise: Development and manufacture of biologicals, bioprocessing, diagnostics, instrumentation products, pharmaceuticals, veterinary products. Analytical chemists, biochemical engineers, biochemists, cell biologists, cell culture engineers, fermentation engineers.

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Technological expertise: BI, CSDP, FE, BC, COC, C/TC, MAE Principal products/instrumentation: Cell/ tissue culture products, custom organic synthesis products. Main products/instrumentation under R&D: Biologicals, drug delivery platform, drug design through disjunction, specialty biochemical.

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983 DYADIC INTERNATIONAL, INC. Add: 140 Intracoastal Pointe Drive Jupiter, FL 33477-5094 Tel: (561) 743-8333 Fax: (561) 743-8343 E-mail: [email protected] Web site: www.dyadic-group.com President/CEO: Mark Emalfarb

981 DUKE SCIENTIFIC CORP. Add: 2463 Faber PL Palo Alto, CA 94303 Tel: (415) 424-1177 Fax: (415) 424-1158 President/CEO: Stanley D. Duke R&D expertise: Development and manufacture of biomedical equipment and reagents. Technological expertise: BME, FL, SI Principal products/instrumentation: Bioclean Flourescent Microspheres, Certified Particle Size Standards, Exotic Partides and Powders, Fluorescent Microspheres, BCR Quartz Reference Particles, Research Microspheres and Particles, Covaspheres Reagents. Main products/instrumentation under R&D: Biomedical equipment, reagents.

Research director: Mark Emalfarb R&D expertise: Research and manufacture of industrial enzymes and also development of biological expression systems in bacteria, fungi and yeast along with proprietary expression cassettes and promoters. Technological expertise: E, F, T, P/S, GA, ET, ERT Principal products/instrumentation: Contract manufacturing products, trichoderma enzyme complex, (ACE); Chrysosporium enzyme complex, (NCE); Trichoderma enzyme complex, (ULTRA); Penidllium enzyme complex, B-1. Main products/instrumentation under R&D: Industrial enzymes biological expression system in bacteria, fungi and yeast. Sealed and granted patents: #5,811,381 and several patents pending; Transformation system in the field of filamentous fungal hosts, 6,573,086, U.S.

982 DUNCAN LABORATORIES Add: 4541 Shady Grove Rd. Memphis, TN 38117 Tel: (901) 684-1521 President: Bruce K. Duncan Technological expertise: E, RD, P/S, FL, FE, ET

984 DYAX CORP. Add: One Kendall Square Bldg. 600, SMFL. Cambridge, MA 02139 Tel: (617) 250-5744 Fax: (617) 250-2501

Principal products/instrumentation: U-Genes uracil DMA glycosylase.

President: L. Edward Cannon, Ph.D.

Main products/instrumentation under R&D: Heat sensitive enzymes for research use.

Subsidiary of Merger of Protein Eng. Corp. and Biotage Inc.

Research director: Robert C. Ladner, Ph.D.

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R&D expertise: Development of fully integrated purification and separation products business; phage display platform technology used to develop new therapeutic, diagnostic and separation products manufacture. R&D collaboration: Asahi Chemical, Novo Nordisk, Debio Pharm SA, Epix Medical, Argonex.

985 DYNAL A.S. Add: P.O. Box 158 Skoyen Oslo N-0212 Norway Tel: (47) 22-06-1000 Fax: (47) 22-50-7015 E-mail: [email protected]

Technological expertise: P/S, COC, D-D, CS, P/D

Web site: www.dynal.no

Principal products/instrumentation: Biotage chromatography purification products: PARALLEX System, FLASH and BioFLASH Systems; KILOPREP HPLCs and PRO-PREP Systems.

Research director: Dr. Erik Ruud

Main products/instrumentation under R&D: Affinity Ligands for separations, preclinical; EPI-HNE4 (Elastose Inhibitor), preclinical; phage display platform technology of fully integrated purification and separation products; Imaging agents, preclinical; DX-88, for treatment of angioedema, Phase IV, 2008; Phase II triat of DX-88 (ecallantide) for the prevention of blood loss that occurs during on-pump cardiothoracic surgery, 2007. Subsidiary bodies: Charlottesville, VA. Sealed and granted patents: U.S. patent Nos. 5,571,698; 5,403,484 and 5,223,409 (~2001). Directed evolution of novel binding proteins. 6,979,538, U.S. Fibrin binding moieties useful as imaging agents. 6,984,373, U.S.; Binding polypeptides for B lymphocyte stimulator protein Blys. 7,118,872, U.S.; Method of recovering a nucleic acid encoding a proteinaceous binding domain which binds a target material. 7,118,879; ITI-D1 Kunitz domain mutants as HNE inhibitors, Purification of tissue plasminogen activator. 6,989,369, U.S. 7,078, 383, U.S. Inhibitors of human plasmin derived from the kunitz domains. 6,953,674, U.S.; Binding molecules for human factor VII and factor VIII-like proteins. 6,492,105, U.S.; Fibrinogen binding moieties. 7,041,790, U.S.; other patents are pending.

President/CEO: Jeff Bork R&D expertise: Development of biomagnetic separation technology and associated products in nucleic acid, protein and cell isolation, related novel products manufacture. Technological expertise: Q, GA, P/S, RD, P/P, PIS Principal products/instrumentation: DYNABEADS products for cell, protein and nucleic acid separation, sequence product clean-up, mRNA purification, water parasite and food pathogen detection, automated DNA isolation: DYNABEADS; CELLECtion. Sealed and granted patents: Several patents on magnetic particles and their applications.

986 DYNAL, INC. Add: 5 Delaware Dr. Lake Success, NY 11042 Tel: (800) 638-9416 Fax: (516) 326-3298 E-mail: [email protected] Web site: www.dynal.no President: Greg Blyskal R&D expertise: Development and manufacture of biopharmaceuticals. Technological expertise: PA, P/S, PIS Principal products/instrumentation: Dynabeads Biomagnetic Separation.

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Main products/instrumentation under R&D: New biopharmaceuticals.

987 DYNCORP ATS Add: 2000 Edmund Haley Dr. Reston, VA 22091 Tel: (301) 738-1106 Fax: (301) 738-1109 President: Dan Bannister Research director: Dr. Lou Potash Subsidiary of DynCorp. R&D expertise: Development contract services of experimental vaccine production, safety testing, molecular biology, baculovirus and vaccinia virus recombinants. Key license and trade contracts: NIH, AGMK cell substrate. Technological expertise: C/TC, BS Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trials products, vaccines.

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Microtker®; MRX®; BIOLINX; DMDASTRIPS®; Microfluor®; Immulon®; Removawell®; Removastrips®; Micro-Skater®; Histo-plate®; MRX-HD™; MLX™; Fluorofte™ 1000; DIAS ULTRA™; Revelation™; Microlite 1™; Microlite 2™; AssayWizard™; Ultrawash Plus; Multi-Reagent Washer™; MRW™; Time Manager Software™; Intellisense™; Immulon IB™; Immulon 2HB™; Immulon 4HBX™. Subsidiary bodies: Dynex Technologies GmbH, Denkendorf, Germany; Dynex Technologies, Moscow, Russia; Dynex Technologies, Kowloon, Hong Kong; Dynex Technologies Ltd., Billingshurst, West Sussex, England; Dynex Technologies Ltd. (Guernsey Manufacturing Plant), Peter Port, Guernsey, Channel Islands; Dynex Technologies s.r.o., Czech Republic.

989 DZGENES, LLC. Add: 518 Bonhomme Woods Dr. St. Louis, MO 63132 Tel: (314) 997-6263 Fax: (603) 971-4567 E-mail: [email protected]

988 DYNEX TECHNOLOGIES, INC.

Web site: www.angelfire.com/mo/dzgenes/ index.html

Add: 14340 Sullyfield Circle Chantilly, VA 20155-1683

President: David W. Moskowitz, M.D., M.A., FACP

Tel: (703) 631-7800

Research director: David W. Moskowitz, M.D., M.A., FACP

Fax: (703) 631-7816 E-mail: [email protected] President/CEO: Jim Wishart Research director: Director Phil Brown R&D expertise: Development of biotechnology products (instrumentation and plastics) and products manufacture. Technological expertise: PA, RD, C/TC, CH/S, DD, D-D, GA, HTDS, PMC, P/S Principal products/instrumentation: Microtiter technology products (instruments and plastics);

R&D expertise: Discovery research of disease genes; high throughput genotyping research, related applied products development. Technological expertise: D-D, GA, GT, G, PG, R, Q, BI, COC, CH/S Principal products/instrumentation: Contract research/clinical trial products, vaccines, antibodies, reagents. Main products/instrumentation under R&D: Disease genes discovery, high throughput genotyping.

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990 E&E MEDICAL, S.A. Add: 64 L. Riankour St., Apollon Tower 15A3 Ambelokipi Athens 11523 Greece Tel: (30) 1-699-6191

products — pre-cleaned and silanized specialty waters, gas sampling bags, preservation products, pyrogene free products, low particle products, TOC sampling products. Main products/instrumentation under R&D: Silanized glassware sterile containers.

Fax: (30) 1-692-5903 President: N. D. Epifanis 992 EAGLE STAINLESS CONTAINER

R&D expertise: Research, development and manufacture of blood substitutes, polyclonal antibodies and cell/tissue culture medical products.

Add: 345 Ivyland Rd. Warminster, PA 18974

Technological expertise: PA, P/S, C/TC, BS

Fax: (215) 957-9330

Principal products/instrumentation: Contract development products, clinical tests, diagnostics, vaccines, plastics, reagents.

Web site: www.eaglestainless.com

Main products/instrumentation under R&D: Blood substitutes, polyclonal antibodies, cell/ tissue culture medical products.

R&D expertise: Design laboratory container for pharmaceuticals research.

991 EAGLE PICHER ENVIRONMENTAL SCIENCE AND TECHNOLOGY Add: 200 B.J. Tunnell Blvd. Miami, OK 74354 Tel: (918) 540-1507 Fax: (918) 540-1604

Tel: (215) 957-9333

President/CEO: Hsi Hu Lin, Ph.D. Research director: Joseph Ho

Technological expertise: BME, SI Principal products/instrumentation: Stainless steel drums, biological transfer bottles, dollies, trays, stability testing bottles, special fabrications, hastelloy bottles. Main products/instrumentation under R&D: Laboratory container for pharmaceutical research. Sealed and granted patents: Sight Glass Light; T-Handle Endcap.

President/CEO: Mitch Eddy Research director: Mike Shaw R&D expertise: Development and manufacture of environmental sampling products and related accessories, Pyrogene free products — silanized glassware, sterile containers, TOC sampling products. Joint ventures: IAETL — International Association of Environmental Testing Labs. Technological expertise: PMC Principal products/instrumentation: In vitro toxicology testing method, reagents, glass and plastic environmental sampling containers — pre-cleaned and certified. Chromatography

993 EASTMAN KODAK CO. SCIENTIFIC IMAGING SYSTEMS Add: 343 State St . Rochester, NY 14652-4115 Tel: (800) 225-5352 Fax: (716) 722-3179 Web site: www.kodak.com/daihome/SIS/ksis. shtml R&D expertise: Development, manufacture, marketing and sale of image capture and related products for scientific applications. Technological expertise: Q, RD, P/S, CH/S

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Principal products/instrumentation: BioMax films for autoradiography; Kodak digital science EDAS systems for electrophoresis documentation and analysis; FLAG protein expression detection and purification; Biolyzer rapid analysis system.

Tel: (734) 665-8877

Main products/instrumentation under R&D: Image capture technology, image maker.

R&D expertise: Development, manufacture and market of biological shakers.

994 EAST PORT SCIENTIFIC Add: Rublicova 1/969 Praha 616000 Czech Republic Tel: (42) 02-301-8177 Fax: (42) 02-333-12428 E-mail: [email protected] Web site: www.eastport.cz President/CEO: Sofie Kunayova R&D expertise: Research of lab equipment/ molecular biology/genetic, products manufacture. R&D collaboration: Distributing Agreements: Promega; BMA; MediCult; Techne; Molecular Probes; Alpha Lab; Biddy Sterilin; Molecular Devices. Key sales market contracts: Turner; Vivascience; Jenway; IDT.

Fax: (734) 665-9099 E-mail: [email protected] President/CEO: Ralph O. Boehnke Jr. Research director: Joseph Novotny

Joint ventures: VWR Scientific Products; J.P. Selecta, S.A. Key sales Scientific.

market

contracts:

Principal products/instrumentation: Reciprocal shakers, orbital shakers, incubator shakers, heavy-duty shakers, test tube shakers, flask shakers, separatory funnel shakers, hot plate shakers, blood bag shakers, large capacity shakers, vibratory shakers, platform shakers, etc. Main products/instrumentation under R&D: Mechanical sieve shakers, sieve shakers, other biological shakers.

996 EBIOINFORMATICS, INC. Add: Box 5430 Pleasanton, CA 94566

Technological expertise: CB, C/TC, GA, G, GT, PIS, PG, E, PA, Q, TE, T, SMC, SY

Tel: (925) 426-9966

Principal products/instrumentation: Agriculture, biologicals, chemicals, diagnostics, in vitro toxicology testing products, plastics, reagents, contract research products.

E-mail: [email protected]

Main products/instrumentation under R&D: Laboratory scale purification devices, lab wares, laboratory equipment information management system.

Research director: Tim Littlejohn

995 EBERBACH Add: 505 S. Maple Rd. Ann Arbor, MI 481061024

VWR

Fax: (603) 994-1792 Web site: www.ebioinformatics.com. President/CEO: Howard D. Goldstein R&D expertise: Web-based bioinformatics application service of novel drug research. Technological expertise: BI Principal products/instrumentation: Bionavigator.com. Main products/instrumentation under R&D: Bioinformation network of novel drug development.

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997 ECHELON RESEAEGH LABORATORIES, INC. Add: 420 Chipeta Way, Ste. 180 Salt Lake City, UT 84108 Tel: (801) 588-0455 Fax: (801) 588-0497

pharmaceuticals, cancer biopharmaceuticals (2), preclinical; allergy biopharmaceuticals (1), preclinical; antibody-peptide delivery system, antibody-liposomes delivery system. Sealed and granted patents: Antibody-peptide delivery system; antibody-liposomes delivery system.

Web site: www.echelon-inc.com President: G. Thomas Heath Research director: Glenn D. Prestwich R&D expertise: Research of cell/tissue culture, high throughout drug screening and combinatorial chemistry, novel products manufacture. Technological expertise: PA, C/TC, HTDS, SY, COC Principal products/instrumentation: Biologicals, chemicals, reagents, contract manufacturing products, contract R&D drug products. Main products/instrumentation under R&D: Cell/tissue culture, high throughout drug screening, combinatorial chemistry library.

998 ECLAGEN LIMITED Add: Marischal College Broad St. Aberdeen, Scotland AB9 IAS UK Tel: (44) 122-427-3002

999 ECOGEN S.L. Add: Clos de sant francese 29 Barcelona 08034 Spain Tel: (34) 93-450-2601 Fax: (34) 93-456-0607 E-mail: [email protected] President/CEO: J. Ramon Gonzalez R&D expertise: Molecular biology research, related products development and manufacture. Technological expertise: F, AB, GA, H/CF, Q, T, RD Principal products/instrumentation: Agriculture, thermocyclers, human genome project, expression/cloning reagents, DNA sequencers, visible genetics, disposables, Q. S. P.; Electrophoresis Chambers Hybridization Ovens. Main products/instrumentation under R&D: Molecular hybridization, molecular rearragement, molecular sieve.

Fax: (44) 122-427-3198 President/CEO: Michael Redmond Research director: Graham Carter, Ph.D. R&D expertise: Contract research and development services of protein engineering, including three proprietary antibody engineering technologies, products manufacture.

1000 ECOLOGY PRODUCTS & SERVICES Add: 710 Forestry Rd. P.O. Box 293 Chalk River, ON KOf 1J0 Canada Tel: (613) 589-2378

Key sales market contracts: Media Services Limited, Japan.

Fax: (613) 589-2192

Technological expertise: PA, RD, Q, C/TC, GA, H/CF, P/S

Research director: Willard Fogal

Main products/instrumentation under R&D: Contract research/clinical trials products,

President/CEO: Willard Fogal R&D expertise: Research of lands and forests R&D, medicinal healthcare development and manufacture.

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Sealed and granted patents: Ion exchange for DNA purification, 6,504,021, U.S.

Technological expertise: ET, PS Principal products/instrumentation: ECOPROS, mulches, natural products, natural microbe sources, trees. Main products/instrumentation under R&D: Medicinal healthcare products, healthcare nutrient drug.

1002 EDWARD G, FITZGERALD Add: 34 Junction Square Dr. Concord, MA 01742 Tel: (978) 371-6446 Fax: (978) 371-2266 E-mail: [email protected]

1001 EDGE BIOSYSTEMS, INC.

Web site: www.fitzgerald.fii.com President/CEO: Kevin Fitzgerald

Add: 19208 Orbit Dr. Gaithersburg, MD 20879-4149

R&D expertise: Development and manufacture of antibodies and antigens.

Tel: (301) 990-2685

Technological expertise: E, PA, BA, AB

Fax: (301) 990-0881

Principal products/instrumentation: Biologicals, reagents, vaccines.

E-mail: [email protected] Web site: www.edgebio.com President/CEO: John L. Seed, Ph.D.

Main products/instrumentation under R&D: Monoclonal/polyclonal antibodies.

Research director: John L. Seed, Ph.D. R&D expertise: Development and manufacture of purifications systems for PCRG DNA Sequencing Reactor cleanup, Protein Expression, Gene Expression, cDNA Resource. Technological expertise: Q, GA, G, P/S, P/PS, HTDS, PC Principal products/instrumentation: DNA purification systems (single and multiwell formats: Sequencing reaction clean up, PCR product purification, Plasmid minipreps, Genomic DNA); Seq-to-Clone gene expression services; Mammalian protein expression systems. Main products/instrumentation under R&D: High throughput DNA/PCR purification products, ion exchange for DNA purification, protein expression vector, gene expression systems. Subsidiary bodies: 7800 Airpark Road, 780/ Cessna Avenue, Gaithersburg, MD.

1003 EGYTECH Add: 13, El-Salouly St., Dokki Cairo Egypt Tel: (20) 2-337-0103 Fax: (20) 2-361-5909 E-mail: [email protected] President/CEO: Dr. Mohy Z. Sabry R&D expertise: Import-export of biomedical products and agencies, technical consultations. Key sales market contracts: KPL — Gaithersburg, MD, USA. Technological expertise: E, AF, C/TC Principal products/instrumentation: ELISA, Immunological products, Biologicals, clinical tests, diagnostics, in vitro toxicology testing products, natural products, pharmaceuticals, reagents, vaccines, veterinary products.

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Main products/instrumentation under R&D: Laboratory biomedical equipment, laboratory scale purification devices.

Sealed and granted patents: USA, Europe, and 25 others.

1006 ELANTEC MEDICAL, INC. 1004 EKA CHEMICALS AB Add: Bohus S-44580 Sweden

Add: 85 S. Union Blvd. M-160 Lakewood, CO 80228-2207

Tel: (46) 3158-7000; (46) 3158-7360

Tel: (303) 278-7672

Fax: (46) 3158-7727

Fax: (303) 278-4968

President/CEO: Dag Stromkvist

E-mail: [email protected]

Research director: Domingo Sanchez

President/CEO: R. M. Allen

R&D expertise: Development of bioprocess engineering products and silica media for chromatography, related products research, development and manufacture.

R&D expertise: Development and manufacture of drug delivery systems.

Technological expertise: BP, AMS Principal products/instrumentation: Kromasil high performance chromatography silica for analytical to industrial scale, chiral phases. Main products/instrumentation under R&D: Silica media for chromatography.

1005 ELANEX PHARMACEUTICALS

Technological expertise: AF, AB, DD Principal products/instrumentation: Contract research/clinical trials products, nutraceuticals, biopharmaceuticals, STR, A-VERT, SFX, TAG OFF. Main products/instrumentation under R&D: Drug delivery platform, drug delivery new systems, drug design platform.

1007 ELCATECH, INC.

Add: 22121 17th Ave. SE, Ste. 108 Bothell, WA 98021

Add: 101 N. Chestnut St., Suite 203 WinstonSalem, NC 27101

Tel: (425) 487-3526

Tel: (336) 777-3624

Fax: (425) 486-4630

Fax: (336) 777-3603

Web site: www.elanex.com

E-mail: [email protected]

President/CEO: Lawrence H. Thompson

President/CEO: Dr. George Doellgast

R&D expertise: rHu EPO research, development and manufacture.

Research director: Dr. Mark Triscoft

Technological expertise: SMC, P/S, BA, RD, CB, C/TC Principal products/instrumentation: rHu Epoetin Omega (EPO) as EPOMAX, HEMAX, EPOMEGA. Main products/instrumentation under R&D: rHu EPO Omega, consisting of rHu Epoetin alpha, rHu Epoetin beta, rHu Epoetin delta, etc.

R&D expertise: Development, design and production of ultrasensitive colorimetric assays for measurement of components of blood coagulation and fibrinolysis systems and detection of bacterial food contaminants for (quantitative) measurement of DNA with or without PCR. Technological expertise: C/TC, P/S, GA, H/CF

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Principal products/instrumentation: ELCA™ enzyme-linked coagulation assay, ELFA™ enzyme-linked fibrinolytic assay, ELCAWASH™ microtiter plate washer, EDNA-ELCA DNA detector. Main products/instrumentation under R&D: ELISA-ELCA for C. botulinum toxin testing, pre-AOAC testing; EDNA-ELCA DNA assay; Ultrasensitive colorimetric assays for measurement of blood components.

1008 ELCHROM SCIENTIFIC AG

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Tel: (972) 2-781-883 Fax: (972) 2-781-852 Research director: Michael Inbar, Ph.D. R&D expertise: Development of diagnostic kits and research of DNA products. Technological expertise: DK, COS, BD Principal products/instrumentation: Diagnostic kit, DNA kits, vaccines, reagents. Main products/instrumentation under R&D: Research DNA kits, research reagents, therapeutic grade protein, diagnostic reagents, diagnostic enzymes.

Add: Gewerbestr. 8 Cham CH-6330 Switzerland Tel: (41) 41-743-2535

1010 ELDEX LABORATORIES, INC.

Fax: (41) 41-743-2536 E-mail: [email protected]

Add: 30 Executive Ct. Napa, CA 94558

President/CEO: Dr. B. Kozulic

Tel: (707) 224-8800

Research director: Dr. B. Kozulic

Fax: (707) 224-0688

R&D expertise: Research, development of products of bioseparation technology, electrophoresis, polymer design and technology, chromatography, diagnostics, E.S.R. systems, medical and scientific laboratory disposables.

President/CEO: Stephen A. Amendola

Technological expertise: E, RD, P/S, RA, GA, CH/S, SY Principal products/instrumentation: Precast Mini poly(NAT) and Clearose BG gels for submerged gel electrophoresis of DNA; Submarine electrophoresis system; SEA 2000 apparatus; ESR-Tests (Dispette), Neat Stain, Haztabs. Main products/instrumentation under R&D: Polymer crystallite technology, medical and scientific laboratory disposables for research use.

Research director: Bruce Black R&D expertise: Development and manufacture of precision liquid delivery instrumentation, liquid chromatography instruments. Technological expertise: BME, DKHC, CPHC, SI, HC Principal products/instrumentation: Meterizing pumps, column heater, HPLC gradient pump, fraction collectors, solvent selector valve. Main products/instrumentation under R&D: Precision liquid delivery instruments, liquid chromatography instruments, liquid-liquid chromatography instruments.

Subsidiary bodies: USA, Canada, UK. Sealed and granted patents: 5,458,760; 5,202,007; 5,185,466.

1009 ELDAN TECH., LTD. Add: 28 Piere Koenig St. Talpiot Industrial Area Jerusalem 93469 Israel

1011 E.L.D. PARRY (INDIA), LTD. R&D CENTRE Add: 145, Devanahalli Road Bangalore, Karnataka 560-049 India Tel: (91) 080-847-2629/659/001 Fax: (91) 080-847-2565

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E-mail: [email protected]

Tel: (215) 646-1566

President: P. Ramababu

Fax: (215) 646-8931

R&D expertise: Development and manufacture of sugar, fertilizer, pesticides, and ceramics.

E-mail: [email protected]

Technological expertise: C/TC, BA Principal products/instrumentation: Fertilizer, Paramfos, ceramics, parryware, organic manure, garden bloom, biopesticides, Neemazal. Main products/instrumentation under R&D: Sugarcane, preclinical; teak, Phase I; banana, Phase I, Neem, preclinical; fertilizer, sugar invert injection.

1012 ELECTROLAB LIMITED

Web site: www.emsdiasum.com President/CEO: Stacie Kirsch Research director: Bang Nguyen R&D expertise: Development, manufacture and supply of microscopy, chemicals and accessories, laboratory equipment. Technological expertise: BME, SI Principal products/instrumentation: Laboratory microwave ovens, tissue choppers and slicers, digital cameras. Main products/instrumentation under R&D: Microscopic electrophoresis, microscope condenser, specialty chemicals, biomedical laboratory equipment for drug research.

Add: Northway Trading Est. Tewkesbury, Gloucestershire GL20 8JH UK Tel: (44) 168-429-1007 Fax: (44) 168-429-1006

1014 ELEMENTAL RESEARCH, INC.

E-mail: [email protected]

Add: 9-267 West-Esplanade North Vancouver, BC V7M 1A5 Canada

Web site: www.electrolab.demon.co.uk

Tel: (604) 986-0445

President/CEO: J. Milne

Fax: (604) 986-0071

R&D expertise: Design, development and manufacture of fermenters and related equipment.

E-mail: [email protected]

Technological expertise: F, BA

President: Robert Brown

Principal products/instrumentation: A range of autoclavable fermenters with microprocessor control, in-situ fermenters of standard design, special products made to customer requirements.

Research director: David J. Gray, Ph.D.

Main products/instrumentation under R&D: Fermenters, fermenter fumigation devices, fermenter controller.

Technological expertise: Q, SMC, P/S, AMS, BME

1013 ELECTRON MICROSCOPY SCIENCES Add: P.O. Box 125 Fort Washington, PA 19034

Web site: www.eri-icpms.com

R&D expertise: Research and development of applied mass spectrometry, method development and method validation, GLP/cGMP.

Principal products/instrumentation: Contract research/clinical trials products, laboratory instrumentation, natural products, nutraceuticals, process validation. Main products/instrumentation under R&D: Mass spectrometer, applied mass spectrometry (MS), validation guides.

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1015 ELGA, INC. Add: 2375 Sanders Rd. Northbrook, IL 600626108 President: Rick Mahoney Subsidiary of Protean plc R&D expertise: Development and manufacture of Ultrapure water systems for laboratory, research and industrial application. Technological expertise: P/S, BME Principal products/instrumentation: Detergents, in vitro toxicology testing, process validation, reagents, Maxima ultrapure water systems; UMQ; Prima Reverse Osmosis Systems; Option Pure Water System. Optima/ Optima Plus; Medica. Main products/instrumentation under R&D: Ultrapure water systems for laboratory and industrial use.

1016 ELI LILLY AND CO. Add: Lilly Corporate Center Indianapolis, IN 46285 Tel: (317) 651-1473 Fax: (317) 651-1481 Web site: www.lilly.com President/CEO: Christine Van Marter Research director: August Watanabe, M.D. R&D expertise: Research, development, manufacture, and marketing of pharmaceuticals, medical devices, diagnostic products and animal health products. Technological expertise: RD, F, P/S, PMC, SY, D-D, DD Principal products/instrumentation: U.S. Nizatidine (Axid), Dobutamine (Dobutrex), Somatropin of recombinant DNA origin (Humatrope®), human insulin of recombinant DNA origin (Humulin®) for treatment of diabetes, Fluoxetine Hydrochloride (Prozac), Alimta (Pemetrexed Disodium) for treatment of patients

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with malignant pleural mesothelioma, Cymbalta (Hydrochloride Duloxetine) for treatment of major depressive disorder (MDD), Cialis (Tadalafil) for the treatment of erectile dysfunction, activated proteins to treat vascular disorders, cyclic peptides, insoluble insulin compositions, streptococcus pneumoniae gene sequence. Main products/instrumentation under R&D: Phase III trials of solanezumab (formerly Ly2062430), an antibeta amyloid monoclonal antibody for treating Alzheimer's disease, 2009. Sealed and granted patents: Methods for treating hypercoagulable states of acquired protein C deficiency, 6,268,344, U.S.; Methods for treating vascular disorders using activated protein C, 6,268,337, U.S.; Anhydro- and isomer-a-21978c cyclic peptides, RE39,071, U.S.; Stabilized teriparatide solutions, 6,770,623, U.S.; Insoluble compositions for controlling blood glucose, 6,531,448, U.S.; Insoluble insulin compositions, 6,465,426, U.S; Method of reducing mortality in severe sepsis, 6,489,296, U.S; Method of treating heparin-induced thrombocytopenia, 6,743,426 U.S.; Streptococcus pneumoniae gene, HIO454, H2,071 U.S.; Streptococcus pneumoniae gene sequence for DNA ligase H2,070 U.S.; other patents are pending.

1017 ELISA TECHNOLOGIES, INC. Add: 4581-LNW 6th St. Gainesville, FL 32609 Tel: (352) 337-3929 Fax: (352) 337-3928 E-mail: [email protected] Web site: www.elisatech.com President/CEO: Bruce Putter R&D expertise: Independent laboratory research/development/manufacture and marketing of meat speciation tests kits and food allergy and protein testing kits. Technological expertise: PA, P/S, H/CF Principal products/instrumentation: Contract research/clinical trials products, ELISA-Tek™

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Cooked Meat Species Kit, ELISA-Tek™ Raw Meat Species Kit, ELISA-Tek™ Food Protein Kits, DTEK™ Immune Sticks Raw Meat Speciation Kit. Main products/instrumentation under R&D: Food Allergen Immunoassays, meat speciation tests kits, food allergy and protein testing kits. Marketing of pharmaceuticals, food processing, chemicals, vaccines, veterinary, cosmetics.

1018 ELISA USA, INC.

products, precision laboratory consumables, Exelpette™, Liquipette. Main products/instrumentation under R&D: Laboratory disposable plastics, labwares.

1020 EL-KOBBA CAIRO-EGYPT Add: P.O. Box 80 saria el-kobba 13 dar Elsalam Kobbry El-Kobbay Cairo Egypt Tel: (20) 2-4555-912 Fax: (20) 2-4555-912

Add: 373 280th St. Osceola, WI 54020

Web site: www.HHNBIO.com

Tel: (715) 294-2144

President/CEO: Peter Wreide

Fax: (715) 294-3921

R&D expertise: Development and manufacture of drugs, laboratory reagents and equipment.

President/CEO: Gottfried Merman, Ph.D. R&D expertise: Development and manufacture of medical diagnostic products. Technological expertise: F, C/TC, RD, P/S Principal products/instrumentation: SYNelisa and Varelisa product line for autoimmune diseases, thyroid, diabetes and rheumatology, therapeutical drugs. Main products/instrumentation under R&D: TSH-Receptor, medical diagnostic kits, diagnostic reagents, diagnostic enzymes.

1019 ELKAY PRODUCTS, INC. Add: 800 Boston Turnpike Shrewsbury, MA 01545

Technological expertise: HTDS, SMC, H/CF, SY, COC, RD, BS, GA, R, CB, GT, C/TC, AF, D-D, AB, DD, PMC, BI, P/S, E, F, BA, Q, CC, TE, CH/S, PIS, PA Principal products/instrumentation: Organ transplants/culture, biologicals, pharmaceuticals, biomaterials, biosensors, reagents, chemicals, human genome project, toxic waste processing, vaccines, contract manufacturing products, in vitro toxicology testing, contract research/clinical trials products, natural products. Main products/instrumentation under R&D: Diagnostic reagents, laboratory scale purification devices.

Tel: (508) 845-2116 Fax: (508) 842-1338 President/CEO: Sean Sweeney

1021 ELLARD INSTRUMENTATION, LTD.

R&D expertise: Development and manufacture of laboratory disposable plastics, OEM, private label and custom design.

Add: 1017 E. Union St. Seattle, WA 98122

Key sales market contracts: Stick Safe

Tel: (206) 328-2787

Technological expertise: BME

Fax: (206) 328-7303

Principal products/instrumentation: Combiplates®, Elkay®, contract manufacturing

E-mail: [email protected] Web site: www.earthlink.net/~eiltd

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President/CEO: Clive Ellard

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1023 EMBRYOTECH LABORATORIES

Research director: Clive Ellard R&D expertise: Development, manufacture and distribution of scientific lab instruments, electrophoresis, biotechnology products. Technological expertise: BME, CS, BD, AU Principal products/instrumentation: H2323 MT Microtiter System, HMG 23/HMG 34 Minigel system, custom gamma radiation shield, custom prototype electrophoresis/biotechnology. Main products/instrumentation under R&D: Labwares, laboratory instruments/equipments of drug research. Sealed and granted patents: LengthBoards — Child measuring boards, # Des. 308,643, 1990.

1022 ELUTIONS, INC. Add: 4915 South Huron St. Englewood, CO 80110 Tel: (303) 762-0183 Fax: (303) 343-6666 E-mail: [email protected] President/CEO: Diane Kozwich Research director: Diane Kozwich R&D expertise: Contract research and products manufacturing of biotechnology medicines, specializing in protein biochemistry, molecular biology technology and immunology technology. R&D collaboration: Immunological Associates of Denver.

Add: 323 Andover St. Wilmington, MA 01887 Tel: (978) 658-4600 Fax: (978) 658-5777 Web site: www.embryotech.com President/CEO: Eric Dorman Research director: Eric Dorman R&D expertise: Development and products manufacture of in vitro toxicology, embryology, transgenics and infertility. R&D collaboration: Ludwig Specialty Media, Inc. Key sales market contracts: Ludwig Institute Media, Inc.; Taconic Farms; Fertility Gies. Inc. Key license and trade contracts: Ludwig Institute. Technological expertise: C/TC, GT, RD, T Principal products/instrumentation: In vitro toxicology testing products, EmbryotechTM, EELI-8C™. Main products/instrumentation under R&D: Conditionally immunological transgenic cell lines; primary mouse embryonic broblasts; transgenic system, embryonic stem cell.

1024 EMERALD BIOSTRUCTURES, INC. Add: 7869 N.E. Day Rd. W. Bainbridge Island, WA 98110 Tel: (206) 780-8535

Technological expertise: BA, C/TC, COC, GA, PIS, P/S, Q, SY, RD, E, F.

Fax: (206) 780-8549

Principal products/instrumentation: Contract research/clinical trial products, organ transplants/ culture products, process validation, vaccines, antibodies, reagents.

Web site: www.emeraldbiostructures.com

Main products/instrumentation under R&D: Forest encephalitis vaccine, protein drugs, protein hormone, molecular sieve carrier.

R&D expertise: Macromolecular X-ray crystallography research services and products manufacture.

E-mail: [email protected] President/CEO: Lance Stewart, Ph.D. Research director: Hidong Kim, Ph.D.

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Key license and trade contracts: Crystal growth matrices licensed from the University of Washington (Seattle, WA). Technological expertise: E, F, R, BI, C/TC, COC, CH/S, D-D, GA, HTDS, P/S, RD

1026 E. MERCK Add: Frankfurter St. 250 Darmstadt, Hessen 64271 Germany Tel: (49) 61-51-72-0

Principal products/instrumentation: Contract manufacturing products, contract research/clinical trials products, natural products, reagents, vaccines, Crystal growth matrices, Crystal growth plates, Compact, Crystal Monitor™, Software/Workstation.

Fax: (49) 61-51-722-000

Main products/instrumentation under R&D: Crystal Growth Robotics, macromolecular X-ray crystallography, macromolecular crystallographic structure.

Technological expertise: D-D

1025 EMERALD DIAGNOSTICS, INC.

President/CEO: Dr. Hans Joachim Langmann R&D expertise: Research, design, development and manufacture of biopharmaceuticals and chemicals. Principal products/instrumentation: Pigments (Triodin™), liquid crystals; biologicals, pharmaceuticals, diagnostics, chemicals, reagents, cosmetics. Main products/instrumentation under R&D: Biological agent, biological defense modifier, biopesticides, specialty chemicals.

Add: P.O. Box 22510 Eugene, OR 97402 Tel: (541) 686-5989

1027 EM INDUSTRIES, INC.

Fax: (541) 343-0723 E-mail: [email protected] President/CEO: Dr. Geoffrey V. E. Seaman Research director: Dr. Michael Brinkley R&D expertise: Research of clinical diagnosis and biotechnology industries with expertise in fluorescent and colored polymer microspheres. R&D collaboration: Luminex Contract Key license and trade contracts: MicroSure. Technological expertise: PA, P/S, SMC, SY Principal products/instrumentation: Diagnostic kits, diagnostic enzymes, monoclonal antibodies. Main products/instrumentation under R&D: Reagents, contract manufacturing products, process validation, rapid pregnancy test and tests for various conditions and infectious diseases. Long wavelength fluorescent dyes.

Add: Health & Human Nutrition 7 Skyline Dr. Hawthorne, NY 10532 Tel: (800) EMI-4535 Fax: (914) 785-5815 Web site: www.HHNBIO.com President/CEO: Peter Wreide Research director: Tessa Chao R&D expertise: Development and manufacture of products utilized in upstream and downstream processing of bio-therapeutics. Joint ventures: VWR Scientific. Technological expertise: P/S, BA, PIS Principal products/instrumentation: Contract manufacturing produces, reagents, vaccines, Fractogel Tentacle, Licrospher, Licroprep, Fractoflow membranes. Main products/instrumentation under R&D: Applied products utilized in upstream and downstream processing of biologicals.

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Subsidiary bodies: BDH, Toronto, Canada; EM Science, Gibbstown, NJ; Merck, KGaA, Darmstadt, Germany; NovaSep, Nancy, France. Sealed and granted patents: Tentacle Chemistry.

1028 EMISPHERE TECHNOLOGIES Add: 240 Cedar Knolls Rd., Suite 200, Cedar Knolls, NJ 07927-1621 Tel: (973) 532-8000 Fax: (973) 532-8115 E-mail: [email protected] Web site: www.emisphere.com CEO: Bob Madison R&D expertise: Development and product manufacture of drug delivery — oral delivery or macromolecules. R&D collaboration: Novartis; Eli Lilly; Regeneron. Technological expertise: SMC, COC, DD Main products/instrumentation under R&D: Oral Heparin, Phase III; macromolecules, Calatonin, Phase I; Oral CNTF, preclinical, delivery agents components; Phase III trial of salmon calcitonin combined with Emisphere's proprietary Eligen Technology for the treatment of vertebral fractures in postmenopausal women with osteoporosis, 2008. Sealed and granted patents: Compounds and compositions for delivering active agents, 7,138,546, and 6,960,355, U.S.; Active alent transport systems, 6,916,489, U.S.; Polymeric delivery flents and delivery agents compounds, 6,627,228, U.S.; Orally deliverable supramolecular complex, 6,348,207, U.S.

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E-mail: [email protected] Web site: www.emscience.com President/CEO: Thomas Coclough Subsidiary of E Merck, Darmstadt R&D expertise: Contract development and manufacture of laboratory reagents, IVD chemical and OEM products. Technological expertise: E, PA, AF, CW Principal products/indtrumentation: Reagents and biotechnology medicines. Main products/instrumentation under R&D: Laboratory diagnostic reagents, specialty chemicals. Subsidiary bodies: Norwood, Ohio; Toronto, Ontario, Canada. 1030 ENDOGEN, INC. Add: 30 Commerce Way Woburn, MA 018011059 Tel: (617) 225-0055 Fax: (617) 225-2040 Web site: www.endogen.com President/CEO: Owen Dempsey Research director: Dr. Christine Burns R&D expertise: Development and manufacture of cytokines and other biomedical research products. Technological expertise: C/TC, RD, P/S, H/CF Principal products/instrumentation: Endogen™ cytokine kits, Minikits™, Cytokine Ten-Packs and other biotechnology. Main products/instrumentation under R&D: Cytokine induced-killer cells, cytokine receptor, cytokine therapy, cytokinin.

1029 EM SCIENCE Add: 480 S. Democrat Rd. Gibbstown, NJ 08027 Tel: (856) 423-6300 Fax: (856) 423-0529

1031 ENDO PHARMACEUTICALS, INC. Add: 223 Wilmington West Chester Pike Chadds Ford, PA 91317

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Tel: (610) 558-9800 Fax: (610) 558-7699 E-mail: [email protected]

Principal products/instrumentation: Oral vaccines, oral human growth hormone, other peptide products.

President/CEO: Carol Ammon

Main products/instrumentation under R&D: ImmTher — Phase III, Perillyl alcohol — Phase II, oral drug and vaccine delivery.

R&D expertise: Pain management, development and manufacture of drugs against pain.

Subsidiary bodies: 28101 N. Ballard Dr., Lake Forest, IL.

Joint ventures: Perm West — drug delivery systems.

Sealed and granted patents: U.S. 4,950,645; U.S. 5,416,070; U.S. 5,762,904.

Web site: www.endo.com

Key license and trade contracts: Hind Health Care — lidoderm patch (lidocaine). Technological expertise: DD, SMC, SY, CS

1033 ENDOVASC, LTD. INC.

Principal products/instrumentation: Percocet, Percodan, Lidoderm, Symmetrel, Numorphan.

Add: 15001 WaJden Rd., Suite 108 Montgomery, TX 77356

Main products/instrumentation under R&D: Drugs against pain, pain reliever, painkiller.

Tel: (409) 448-2222 Fax: (409) 582-2250 E-mail: endovasc.com

1032 ENDOREX CORPORATION

Web site: www.endovasc.com President/CEO: David P. Summers, Ph.D.

Add: 28101 N. Ballard Dr. Ste. F, Lake Forest, IL 60045 Tel: (847) 573-8990 Fax: (847) 573-9285 E-mail: [email protected] Web site: www.endorex.com President/CEO: Michael S. Rosen

R&D expertise: Development of liposomal drug delivery. Technological expertise: RD, CB, COC, GT Main products/instrumentation under R&D: Biomaterials, contract manufacturing products, biopharmaceuticals, prostaglandin E-l in TM; liposome (liprostin), preclinical, liposomal drug delivery system.

Research director: Robert N. Brey, VT R&D expertise: Drug design and oral delivery of proteins and peptides; Drug delivery development and drug manufacture. Joint ventures: Elan Pharmaceuticals, pic. R&D collaboration: University of Wisconsin, Madison; Novo Nordisk A/S. Key sales market contracts: Schein Pharmaceutical, INC.

1034 ENERGY BIOSYSTEMS CORP. Add: 4200 Research Forest Dr. The Woodlands, TX 77381 Tel: (713) 364-6100 Fax: (713) 364-6110 E-mail: [email protected]

Key license and trade contracts: MIT/Wise. Alum. Res.

Web site: www.energybiosystems.com

Technological expertise: DD, D-D

Research director: Daniel J. Montkello, Ph.D.

President/CEO: John H. Webb

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R&D expertise: Desulfurization research of oil; bioprocessing of fossil fuels, related products manufacture.

Key license and trade contracts: Graftek Image Analysis Software for North America.

Joint ventures: The Carbide/Graphite Group.

Principal products/instrumentation: ETC 3,000 Image Analysis System, Concept VI and Ultimate Image Analysis Software, GEL scanners for GEL electrophoresis image analysis, Image analysis software.

R&D collaboration: Texaco exploration and production technology, Total Raffinage Distribution, SA; Kuck Refining Co. Key sales market contracts: Petrolite Corporation, Mitsubishi Trust & Banking Corporation. Technological expertise: F, Q, E, RD, P/S, CH/S Main products/instrumentation under R&D: Biocatalytic desulfurization (BDS), pilot stage, BDS process technology of biocatalyst genes. Sealed and granted patents: 20 U.S. and 32 foreign patents; 12 patent applications pending in the U.S. Patent Office and more than 60 foreign patent applications pending to cover BDS process technology and the molecular cloning of the biocatalyst genes.

Technological expertise: C/TC, CH/S, R

Main products/instrumentation under R&D: Cell tracking motion control for sequential measurement of cell growth, image signal processing systems.

1036 ENPRO, INC. Add: 121 South Lombard Rd. Addison, IL 60101 Tel: (630) 629-3504 Fax: (630) 629-3512 E-mail: [email protected] Web site: www.enproinc.com President/CEO: Brian Cook

1035 ENGINEERING TECHNOLOGY CENTER BUSINESS UNIT OF ANALYSIS AND TECHNOLOGY, INC. Add: 240 Oral School Rd. Mystic, CT 063551208 Tel: (800) 959-3011 Fax: (860) 572-7328 E-mail: [email protected] Web site: www.etc.aati.com President/CEO: Robert Gorman Subsidiary of Analysis and Technology, Inc. R&D expertise: Development of image analysis and signal processing systems, products manufacture. Key sales market contracts: Graftek and Graftek distributors.

R&D expertise: Research of solving filtration and aseptic processing problems in a most economical manner, related products development and manufacture. Technological expertise: P/S Principal products/instrumentation: Biomaterials, bioremediation, specialty chemicals, cosmetics, biopharmaceuticals, plastics, process validation, reagents, toxic waste processing, vaccines, components used in the industry — Pall, Asepco, G & H, Alfa-Laval Flexible Components, Purefit. Main products/instrumentation under R&D: Solving filtration manifold.

1037 ENSOLVE BIOSYSTEMS, INC. Add: 3209 Gresham Lake Rd., Ste. 147 Raleigh, NC 27615

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Tel: (919) 954-6196 Fax: (919) 954-6197

Main products/instrumentation under R&D: Nonmetallic fluid handling systems.

E-mail: [email protected] President/CEO: Dr. Jason A. Caplan

1039 ENTELECHON

Research director: Dr. Donald Kelemen R&D expertise: Development and manufacture of biotechnology solutions for industry.

Add: Josef-Engert-Strasse 9 Regensburg, Bayern 93053 Germany

Key sales market contracts: Burlington Chemical and Tridelta Technologies (Grease Feast® Biocleanser).

Tel: (49) 941-946-8360

Key license and trade contracts: EnviroSys (EnCell Bioreactor).

President/CEO: Dr. Werner Deininger

Technological expertise: E, F, BA, C/TC Principal products/instrumentation: GreaseFeast® Biocleanser, EnCell Bioreactor, EnBac Microbes. Main products/instrumentation under R&D: Air Biofilters, early development biotechnology solutions. Sealed and granted patents: EnCell Bioreactor, (U.S. patent # 5,807,485).

Fax: (49) 941-946-8366 Web site: www.entelechon.com R&D expertise: Research and development of genomics and gene amplification, related products manufacture. Technological expertise: SY, CS, G, GA Principal products/instrumentation: Synthetic genes. Main products/instrumentation under R&D: Genomic DNA, genomic fingerprinting, gene amplification technology, gene complex, gene specific transcription factor. Sealed and granted patents: Gene synthesis.

1038 ENTEGRIS, INC. Add: 3500 Lyman Blvd. Chaska, MN 55318

1040 ENTELOS, INC.

Tel: (612) 448-8196 Fax: (612) 556-8022 E-mail: [email protected] Web site: www.entegris.com President/CEO: Stan Geyer R&D expertise: Development and related products manufacture of nonmetallic fluid handling systems capable of handling regular SIP/CIP cycles. Technological expertise: BME, SI, C/TC Principal products/instrumentation: Tubing/pipe, Cynergy™; fittings, Cynergy™; valves, Cynergy™; cynergy™ bead-less weld equipment.

Add: 4040 Campbell Av., Suite 200 Menlo Park, CA 94025 Tel: (650) 330-5200 Fax: (650) 330-5201 Web site: www.entelos.com President/CEO: Sam Holtzman R&D expertise: Development, manufacture and sales of computer-based disease simulation systems called PhysioLabs. Technological expertise: D-D, BI, CH/S Principal products/instrumentation: Contract development products, Entelos Asthma PhysioLab.

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Main products/instrumentation under R&D: Computer-based disease simulation systems.

Key sales market contracts: Sigma, SKD, Abbott.

Sealed and granted patents: pct/jp2008/052828: (wo 2008/105288) synthetic resin granulating die; pct/jp2008/052769: (wo 2008/102779) method of manufacturing pressure vessel; pct/jp2008/052769: (wo 2008/099663) method of working workpiece of highly brittle nonmetallic material and apparatus thereof; pct/jp2008/051429: (wo 2008/096651) hydrogen filling apparatus; pct/jp2008/050916: (wo 2008/090932) sensor for residual amount of hydrogen; pct/jp2007/072512: (wo 2008/072454) production method of crystalline semiconductor film and heating control method of semiconductor film and semiconductor crystallizing device; pct/jp2007/066521: (wo 2008/035541) volatilization performance estimating apparatus and method of estimating volatilization performance; pct/jp2007/056064: (wo 2007/ 119506) simulation apparatus for screw extruder volatilization and simulation program for screw extruder volatilization; pct/jp2007/000079: (wo 2007/116576) laser irradiation device; pct/ jp2006/323320: (wo 2007/066516) method of forming blow-molded article and molding apparatus; pct/jp2006/318000: (wo 2007/034704) process for producing hydrogen-storage alloy; pct/jp2006/315572: (wo 2007/018167) laser projection device; pct/jp2006/311069: (wo 2006/ 134785) laser irradiation method and device thereof.

Key license and trade contracts: Baylor College of Medicine, McGill University. Technological expertise: C/TC, P/S, BA, H/CF Principal products/instrumentation: HMCAP immunoassay for H. pylori Ig; D14 monoclonal antibody, E-Z-mouth guard suction polyp trap. Main products/instrumentation under R&D: Diagnostic/treatment/prevention drugs for gastrointestinal diseases and disorders.

1042 ENTOPATH, INC. Add: 3555 Timberlane Dr. Easton, PA 18045 Tel: (610) 250-0946 Fax: (610) 250-7078 President/CEO: Lloyd E. Browne R&D expertise: Development and manufacture of insect kits for in vivo baculovirus expression of recombinant protein production. Technological expertise: D, T, RD Principal products/instrumentation: T.mi quick kit. Main products/instrumentation under R&D: Insect kits for in vivo baculovirus expression of recombinant protein, insect spray, insect repellent.

1041 ENTERIC PRODUCTS, INC. 1043 ENTREMED, INC. Add: 717 Main St. Westbuxy, NY 11590 Tel: (516) 333-8230 Fax: (516) 333-8278 E-mail: [email protected] President/CEO: Robert M. Bloomfield R&D expertise: Development and manufacture of related products to detect, diagnose, monitor, treat and prevent gastrointestinal diseases and disorders.

Add: 9640 Medical Center Dr. Suite 200 Rockville, MD 20850 Tel: (301) 217-9858 Fax: (301) 217-9594 Web site: www.entremed.com President/CEO: John W. Holaday, Ph.D. R&D expertise: Research of biopharmaceuticals, blood and blood vessels in health and

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disease; angiogenesis and cell permeation technology, related products manufacture.

R&D expertise: Manufacture and design of clean air and containment equipment.

R&D collaboration: Bristol-Myers Squibb Company.

Technological expertise: BME, AF

Key license and trade contracts: Children’s Hospital, Harvard School of Medicine; Harvard Center for Blood Research. Technological expertise: AF, BS, C/TC, GA, HTDS, H/CF, P/S, Q, SMC, RD Main products/instrumentation under R&D: Thalidomide: Phase II trials for macular degeneration and oncology; Angiogenic inhibitors: other various products, including Angiostatin™ protein in preclinical research and scale-up; Endostatin™ protein, pathway for the treatment of cancer and angiogenic disease, Prototype, preclinical, development of method for treating red blood cells to increase oxygen delivery; Vaccines: preclinical toxicological studies for vaccines against cholesterol, angiogenic growth factors, fungal diseases; method for detection of HIV virus, and other agents in blood; oncology prognostic based on angiogenic inhibitors and stimulators. Sealed and granted patents: Thalidomide for angiogenesis; Angiostatin™ protein; electroporation of red blood cells; Endostatin™ Protein. Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease, 6,593,291.

1044 ENVAIR, LTD. Add: York Ave. Haslingden Rossendale, Lanes BB4 4HX UK

Principal products/instrumentation: BIO 2+, class 2 microbiological safety cabinet; PharmAssist, flexible/rigid isolator/glove box; CDC’C; containment isolator/glove box; powder control booths, air showers, laminar flow equipment. Main products/instrumentation under R&D: Clean air/containment equipment, gas contaminant containment facility.

1045 ENVIROGEN, INC. PRINCETON RESEARCH CENTER Add: 4100 Quakerbridge Rd. Lawrenceville, NJ 08648 Tel: (609) 936-9300 Fax: (609) 936-9221 Web site: www.envirogen.com President/CEO: Robert S. Hillas Research director: Ronald Unterman, Ph.D. R&D expertise: Technology research of bioremediaiton, soil vapor extraction and pollution control, related products development. Key license and trade contracts: Amgen Technological expertise: F, RD, PMC, CH/S Principal products/instrumentation: Soil vapor extraction (“Vapex Technologies”), biofilters, fluid bed reactors, membrane bioreactors. environmental bioremediation, Main products/instrumentation under R&D: Pollution control devices, bioremediation reactor. Subsidiary bodies: Houston, TX; Pewaukee, WI; Geneva, IL; Mosinee, WI; Canton, MA; Lansing, MI; Ashwaubenon, WI; Onalaska, WI.

Tel: (44) 170-622-8416 Fax: (44) 170-683-1957 E-mail: [email protected] Web site: www.envair.co.uk President/CEO: John Neiger

1046 ENVIRONICS, INC. Add: 69 Industrial Park Rd. East Tolland, CT 06084

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ColiPlate™, (testing kit for coliforms and E.Coli; quantitative). Main products/instrumentation under R&D: In-home water testing kits, environmental pollutant testing equipment.

President/CEO: Terrence P. Dunn R&D expertise: Gas mixing using very precise control of thermal mass flow controllers. Environics accuracy specifications are +/- 1% of reading. Technological expertise: BME, BTS Principal products/instrumentation: S-2000 Computerized Gas Mixer; S-2020 Computerized Gas Dilution System; S-2010 Computerized Gas Divider; S-4000 Windows based Computerized Gas Mixer; S-4040 Windows based Computerized Gas Dilution System. Main products/instrumentation under R&D: Ozone generator, thermal mass flow controllers. Sealed and granted patents: Ozone generator.

1048 ENVIRONMENTAL GROWTH CHAMBERS Add: 510 E. Washington St. Chagrin Falls, OH 44022 Tel: (800) 321-6854 Fax: (440) 247-8710 E-mail: [email protected] Web site: www.egc.com President/CEO: A. O. Rule III R&D expertise: Design, development and manufacture of controlled environments for research. Technological expertise: R, BME

1047 ENVIRONMENTAL BIO DETECTION PRODUCTS, INC. (EBPI) Add: 14 Abacus Rd. Brampton, Ontario LGT 5B7 Canada Tel: (416) 794-3274 Fax: (416) 794-2338 President/CEO: Ran Lifshitz, Ph.D. R&D expertise: Applied research of environmental testing technology; related products research and development. Technological expertise: E, RD Principal products/instrumentation: Toxi Chromotest (testing kit for toxicity), SOS Chromotest (testing kit for genotoxicity), Toxi-ChromoPad™, (testing kit for toxicity in sediments); Muta-Chromo-Plate, (testing kit for mutagenicity); ColiBag™, (testing kit for coliforms and E. Coli; presence/absence);

Principal products/instrumentation:, Incubators; environmental rooms and chambers; plant growth chambers; cold rooms and freezers. Main products/instrumentation under R&D: Refrigeration systems, controlled environments for research. Sealed and granted patents: Refrigeration, water cooled lamps, paper testing room.

1049 ENVIRONMENTAL REMEDIATION, INC. Add: 11800 Industrial Plex, Ste. 4 Baton Rouge, LA 70809 Tel: (504) 751-4476 Fax: (504) 751-4225 President/CEO: J. Peter Perez Research director: John Christiansen

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R&D expertise: Manufacture and development of bacterial cultures.

Tel: (516) 755-5500

Key sales market contracts: To be announced — Hamburg, Germany — teaming agreement to market biological product for golf courses.

President/CEO: Elazar Rabbani, Ph.D.

Technological expertise: F, C/TC Principal products/instrumentation: BioSeed™, BioFree™, MicroPro™. Main products/instrumentation under R&D: Bacterial culture products, drugs to degrade algae in ponds final phase. Subsidiary bodies: Manufacturing: Denharn Springs, LA; Houston, TX; Dublin, Ireland; Sales offices: Kansas City, MO; Los Angeles, CA; Hilton Head, SC; Elkton, MD; Vancouver, WA; Naperville, IL; Slough, England.

1050 ENVIRO-ZYME INTERNATIONAL, INC. Add: P.O. Box 169 Stormville, NY 12582 Tel: (800) 882-9904 Fax: (914) 878-7917

Fax: (516) 755-5569 Research director: Norman Kelker, Ph.D. R&D expertise: Diagnostic research services, development of diagnostic products based on DNA probes and therapeutic and agricultural products using antisense nucleic acids. Key license and trade contracts: Yale University, biotinylated nucleic acids; SUNY Research Foundation, genetic antisense technology. Technological expertise: Q, T, GT, AB, C/TC, RD, GA, H/CF Principal products/instrumentation: PathoGene™ DNA probe assays for HPV; HSV, EBV, HBV, Chlamydia, CMV; BioPap™ HPV DNA assay for cervical smears, microplate hybridization assays for HIV, MTB. Main products/instrumentation under R&D: Microplate hybridization assays for various pathogens, diagnostic DNA probes, therapeutics from antisense nucleic acids.

E-mail: [email protected] Web site: www.envirozyme.com

1052 ENZON, INC.

President/CEO: Jay Silverstein Research director: Jay Silverstein R&D expertise: Design and development of bacterial enzyme/cultures for wastewater treatment and bioremediation, related products manufacture. Technological expertise: F, C/TC, LP, PMC Principal products/instrumentation: Biologicals, enzymes, single cell proteins, specialty chemicals, bacterial cultures for wastewater and bioremediation, “Enviro-Zyme”: a registered trademark belonging to Enviro-Zyme Int’l.

1051 ENZO BIOCHEM, INC. Add: 60 Executive Blvd. Farmingdale, NY 11735

Add: 20 Kingsbridge Rd. Piscataway, NJ 08854 Tel: (732) 980-4500 Fax: (732) 980-5911 President/CEO: Abraham Abuchowski Research director: Robert Shorr, Ph.D. R&D expertise: Development and manufacture of advanced therapeutics for life-threatening diseases through the application of Enzons proprietary technologies, Pegnology and SCA™ proteins. Joint ventures: Schering Corp., Sterling Winthrop, Inc. Celtrix Labs, Inc., Genelabs Technologies, Inc., Emisphere Technologies, Inc., Neoprobe Corp.

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R&D collaboration: American Veterinary Products, Oncologix, Inc. Technological expertise: DD, D-D, DDI, CS Principal products/instrumentation: ADAGEN™ (pegademase bovine injection), enzyme replacement therapy for treatment of severe combined immunodeficiency disease(SCID); Oncaspar® DEG-1-asparaginase for first-line treatment of acute lymphoblastic leukemia. Main products/instrumentation under R&D: ONCASPAR™, PEG-gluco-cerebrosidase, PEG-hemoglobin, PEG-Intron® A: interferon alfa-2b (recombinant) to treat hepatitis C, application submitted; chronic myelogenous leukemia, malignant melanoma, renal cell carcinoma, and infectious diseases, Phase II; PEG-Intron® A/Rebetol™, interferon alfa-2b for cancer, chronic hepatitis C, Phase III–IV; prothecan® PEG-camptothecin to treat cancer, Phase II. Sealed and granted patents: Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof, 6,743,908 6,743,908, U.S.; Single-chain polypeptides for targeted delivery of nucleic acids, 6,692,942, U.S.; Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof, 6,323,322, U.S.

1053 ENZYMATICS, INC. Add: 1745 Eaton Ave. Bethlehem, PA 180181707 Tel: (215) 674-3288 Fax: (215) 674-3273 President/CEO: S. Wayne Kay

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Principal products/instrumentation: Q.E.D.® saliva alcohol tests, Q.E.D.® total cholesterol test. Main products/instrumentation under R&D: Other blood lipid tests, including HDL cholesterol test, triglycerides test, total cholesterol to HDL ratio test, quantitative, rapid, noninstrumented medical diagnostic tests.

1054 ENZYMED, INC. (A DIVISION OF AMRI) Add: 2501 Crosspark Rd. C-150 Iowa City, IA 52242 Tel: (319) 626-5400 Fax: (319) 626-5410 E-mail: [email protected] Web site: www.enzymed.com President/CEO: Donal Kohla Research director: John Krstenansky, Ph.D. R&D expertise: Discovery drug research, design, development and manufacture of custom services. R&D collaboration: Merck and Co., Novartis Crop Protection AG, IntraBiotics Pharmaceuticals, Inc., F. Hoffmann-LaRoche AG, RiboGene, Inc.. Aquasearch, Inc. Technological expertise: B, CC, E, F, SMC, SY, BA, CB, COC Principal products/instrumentation: Contract research/clinical trials products, natural products, nutraceuticals, pesticides. Main products/instrumentation under R&D: Drug discovery route, drug screening program.

Research director: John L. Palmer, Ph.D. R&D expertise: Research, design, development, manufacturing and marketing of quantitative, rapid, non-instrumented medical diagnostic tests. Technological expertise: E, BS, ET, ERT

1055 ENZYME SYSTEMS PRODUCTS, INC. Add: 486 Lindbergh Ave. Livermore, CA 94550

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Tel: (888) 449-2664 Fax: (925) 449-1866 E-mail: [email protected] Web site: www.enzymesys.com President/CEO: J. M. KinderSmith Research director: Jamil W. Talhouk, Ph.D. R&D expertise: Research reagents, drug discovery and design/manufacture. Technological expertise: SMC, SY, P/S, CB, DDI, D-D Principal products/instrumentation: Enzymes, specialty chemicals, monoclonal antibodies, kits, fluorogenic and chromogenic substrates, specific inhibitors. Purified enzymassay kits (diagnostics), fluorescent substrate irreversible non-toxic protease. Main products/instrumentation under R&D: Inhibitors specific for apoptosis — serine protease inhibitors, MMPs, antibodies; fluorescent cell permeable substrate (red region); Cysteine protease inhibitor; serine secretase substrate and inhibitor; Treatment of disease, including Neurological-ALS, spinal cord injury, degenerative-osteoarthritis. Sealed and granted patents: AFC fluorescent substrates, Fluoromethyl ketones, FMK inhibitors.

Technological expertise: E, Q, T, F, LP, BA, GA, P/S, RD Principal products/instrumentation: FailSafe™ PCR System; EZ: TN™ Transposon Tools; GELase™ agarose gel-digesting preparation; Fast-Link™ DNA ligation and screening kit, Plasmid-Safe™ DNasc; MasterAmp™ PCR and RT-PCR enzymes and kits; Ampligase™ thermostable DNA sequencing kit; AmpliScribe™ T7, SP6, and T3 high yield transcription kits; SequiTherm EXCEL™ DNA sequencing kit; MaxPlax™ lamda packaging system; BESS-T&G™ Base Reader Kits; HK™ thermolabile phosphatase; HK™ — UNG thermolabile Uracil N-glycosylase; Hybridase™ thermostable RNAse H; Sequitherm EXCEL™ II DNA sequencing kit; Master pure™ DNA/RNA isolation and purification kits. Main products/instrumentation under R&D: Novel diagnostic enzymes, kits and reagents for research/diagnosis.

1057 EPICYTE PHARMACEUTICAL, INC. Add: 5810 Nancy Ridge Dr. Ste. 150 San Diego, CA 92121 Tel: (858) 554-0281 Fax: (858) 554-0288

1056 EPICENTRE TECHNOLOGIES

E-mail: [email protected] Web site: www.epicyte.com

Add: 1402 Emil St. Madison, WI 53713

President/CEO: Mitch B. Hein, Ph.D.

Tel: (608) 258-3080

Research director: Andrew C. Hiatt, Ph.D.

Fax: (608) 258-3089 E-mail: [email protected]

R&D expertise: Development of plant antibody, antibody products in plants manufacture.

Web site: www.epicentre.com

R&D collaboration: To be announced.

President/CEO: Gary A. Dahl, Ph.D.

Key license and trade contracts: The Scripps Research Institute.

R&D expertise: Development and manufacture of enzymes, kits and reagents for molecular biology research and diagnostics. Key license and trade contracts: PCR license from Hoffman LaRoche.

Technological expertise: E, PA, Q, T, CB, C/TC, DD, D-D, P/S, RD Principal products/instrumentation: Contract manufacturing products, in vitro toxicology

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1059 EPITOPE, INC.

Main products/instrumentation under R&D: HSV protection, preclinical; antibody in plants, preclinical; HTV protection, preclinical; CDifficile protection, preclinical; contraception, preclinical.

Add: 8505 SW Creekside PI. Beaverton, OR 97005

Sealed and granted patents: 5,202,422; 5,639,947; 5,959,177; 6,045,786.

President/CEO: Charles Armstrong

1058 EPIGENESIS PHARMACEUTICALS, INC. Add: P.O. Box 7007 Princeton, NJ 08543-7007 Tel: (609) 409-6080 Fax: (609) 409-3037 Web site: www.epigene.com President/CEO: Dr. James C. Mannion Research director: Jonathan W. Nyce, Ph.D. R&D expertise: Drug discovery and development of new therapeutics for respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and allergy drugs. R&D collaboration: Chiesi and Taisho. Technological expertise: CC, GA, HTDS, Q, T, AB, BI, COC, CH/S, DD, D-D, P/S, PG, RD, R, SMC, SY Principal products/instrumentation: EPI2010, EPI-12323. Main products/instrumentation under R&D: Inhibiting carcinogenesis agents, EPI-2010 preventative treatment for asthma, preclinical; EPI-12322 nonglucocorticord steroid for asthma, preclinical. Sealed and granted patents: U.S. #5,660,835 — Method of treating adenosine depletion; U.S. #5,527,789, Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereof.

Tel: (503) 641-6115 Fax: (503) 520-6255 Research director: John Fitchen, M.D. R&D expertise: Development and manufacture of recombinant DNA, gene amplification and purification/separation of protein. Technological expertise: Q, RD, P/S, GA Principal products/instrumentation: Western Blot — Epiblot; oral fluid collection device to be used in conjunction with HIV testing — OraSure. Main products/instrumentation under R&D: Recombinant DNA drug complex, DNA extractor, purified protein derivative.

1060 EPIX, INC. Add: 381 Lexington Dr. Buffalo Grove, IL 60089 Tel: (847) 465-1818 Fax: (847) 465-1919 E-mail: [email protected] Web site: www.epixinc.com President/CEO: Howard M. Dreizen R&D expertise: Design, development and manufacture of imaging hardware and software. Technological expertise: CH/S Principal products/instrumentation: PIXCI™, 4MEG Video™, COC402™, Silicon Video®, MUX™. Main products/instrumentation under R&D: Imaging hardware and software for pharmaceutical research.

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1061 EPIX MEDICAL, INC.

are in, increasing demand in the rapidly expanding field of genetic pharmacology.

Add: 71 Rogers St. Cambridge, MA 02142

Technological expertise: BS, G, HTDS

Tel: (617) 250-6000

Main products/instrumentation under R&D: Pharmaceuticals and biopharmaceuticals, oligonucleotides, target sequence of duplex DNA.

Fax: (617) 250-6031 Web site: www.epixmed.com President/CEO: Stephen C. Knight Research director: James Smith, Ph.D. R&D expertise: Development and manufacture of MRI contrast agents for pharmaceutical industry. R&D collaboration: Dyax, Neogenesis, Schering, AG. Key sales market contracts: Mallinckrodt, Daiichi, Schering, AG. Key license and trade contracts: Massachusetts General Hospital. Technological expertise: P/S, BA, D-D, SY Main products/instrumentation under R&D: Blood pool agent; Angio MARK (MS-325) blood pool MRI contrast agent, Phase III/IV) and thrombus agent, preclinical), MRI Contras for pharmaceutical industry.

Sealed and granted patents: Hydridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders, 6,492,346, U.S.; Bifunctional Crosslinking oligonucleotides adapted for linking to a target sequence of duplex DNA, 6,312,953, U.S.; Methods and compositions to facilitate D-loop formation by oligonucleotides, 6,312,925, U.S.

1063 EPPENDORF-NETHELER-HINZ GMBH Add: Barkhausenweg 1 Hamburg D-22331 Germany Tel: (49) 40-5380-1640 Fax: (49) 40-5380-1662 E-mail: [email protected] Web site: www.eppendorf.com President/CEO: Klaus Fink Research director: Rainer Treptow

1062 EPOCH PHARMACEUTICALS, INC. Add: 122 77 134th Court NE, #110 Redmond, WA 98052-2431 Tel: (425) 821-7535 Fax: (425) 825-0306

R&D expertise: Development and manufacture of laboratory instrumentation systems and disposables for healthcare, industry and research. Key license and trade contracts: PerkinElmer for thermal cyclers in PCR.

President/CEO: Sanford Szweifach

Technological expertise: SMC, H/CF, Q, T, C/TC, GA, P/S, RD

R&D expertise: Research and products development of nucleoside and nucleotide chemistry to develop molecular tools for genetic analysis, proprietary technology in the rational design, synthesis and chemical modification of oligonucleotides, products and techniques for high throughput genetic sequence analysis that

Principal products/instrumentation: Biologicals, biosensors, specialty chemicals, clinical tests, contract manufacturing products, diagnostics, instruments, plastics, process validation, reagents, automated liquid-handling system with pretested, ready-to-go methods for automated nucleic acid purification, 2008;

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Stem Cell Culture Status Profiling, a TF Chip Stem cell kit, enables profiling of the status of a stem cell culture by 12 specific transcription factors in one assay, 2007; Two-phase Pipette Filter, 2007.

Principal products/instrumentation: Automated robotic platforms for nucleic acid purification and preparation. PERFECTprep®-96 for preparation of plasmid and genomic DNA templates.

Main products/instrumentation under R&D: Biomedical laboratory instrumentation systems for pharmaceutical research.

Main products/instrumentation under R&D: Validation of robotic processes, automated DNA preparation.

Subsidiary bodies: Eppendorf Instrumente GmbH, Hamburg, Germany; Eppendorf Polymere GmbH, Oldenburg, Germany; Eppendorf Zentrifugen GmbH, Leipzig, Germany; Eppendorf BioChem GmbH, Berlin, Germany; WALU Labortechnik GmbH, Wertheim, Germany, Eppendorf S.r.l, Milan, Italy; Dr. Vaudeux AG, Basel, Switzerland; Eppendorf-IATRON Co., Ltd., Tokyo, Japan; Eppendorf South Pacific, Pty. Ltd., Sydney, Australia; Brinkmann Instruments, Inc., Westbury, USA; Eppendorf Scientific, Inc., Westbury, USA; USA Scientific, Inc. Ocala, USA; Eppendorf 5 Prime, Inc. Boulder, USA; Eppendorf do Brasil, Ltda., Sao Paulo, Brazil. Regional Offices: Eppendorf, Malaysia; Eppendorf, Madrid, Spain; Eppendorf, Paris, France; Eppendorf, Cambridge, UK; Eppendorf, Wien, Austria; Eppendorf Sales Office, Koln, Germany.

1064 EPPENDORF — 5 PRIME, INC. Add: 5603 Arapahoe Ave. Boulder, CO 80303

1065 EPPENDORF SCIENTIFIC, INC. Add: One Cantiague Rd. Westbury, NY 11590 Tel: (800) 421-9988, (516) 876-6800 Fax: (516) 876-8599 E-mail: [email protected] Web site: www.eppendorfsi.com President/CEO: Martin Farb R&D expertise: Development and manufacture of biomedical equipment and consumables for life science. Technological expertise: F, Q, E, T, GT, RD, P/S, GA, SY Principal products/instrumentation: Cell injection and patch clamp workstations; related consumables; electroporator, transgenic workstation, nucleic acid purification kits, gradient thermal cycler. products for microinjection, molecular biology reagents.

Tel: (303) 440-3705 Fax: (303) 440-0835

1066 EQUIBIO, LTD.

E-mail: @high_throughput.com Web site: www.highthroughput.com President/CEO: Warren Kroeker, Ph.D. Research director: Randolph J. Hellwig, Ph.D. Subsidiary of Eppendorf — Netheler-Hinz GmbH

Add: The Wheelwrights, The Green Boughton Monchelsea Maidstone, Kent ME 17 4LT UK Tel: (44) 0 162-274-6300 Fax: (44) 0 162-274-7060 E-mail: [email protected]

R&D expertise: Automated DNA preparation, related products development and manufacture.

Web site: www.equibio.com

Technological expertise: Q, RD, P/S, HTDS

Research director: Joel Louette

President/CEO: Tom Hole

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R&D expertise: Research and related products development of electroporation and transfection; gene transfer. Technological expertise: T, TE, C/TC, DD, GA, RD, H/CF Principal products/instrumentation: Biosensors, a range of equipment and consumables for electroporation and transfection products, including Easyject™, Optimix, EasyMix, and Easyfector. Main products/instrumentation under R&D: New products for gene transfer technologies, electroporation apparatus. Sealed and granted patents: Within Electroporation.

1067 EQUIPMENT CONNECTION, INC.

President/CEO: Mike Bays Research director: William Fisher R&D expertise: Development and manufacture of biological and immunological reagents, normal animal sera and polyclonal antisera. Joint ventures: Equitech Enterprises, Inc. Technological expertise: PA, P/S, C/TC Principal products/instrumentation: Purified proteins, rabbit brain acetone powder, polyclonal antisera, normal animal sera and plasma, custom antisera. Main products/instrumentation under R&D: Secondary antibodies, primary antibodies, affinity chromatography, biological and immunological reagents.

1069 EQUIVISION GROUP

Add: 9823 Pacific Heights Blvd., Suite A. San Diego, CA 92121

Add: 400 West de Maisonneuve Str. Room 1156 Montreal Quebec H3A 1L4 Canada

Tel: (858) 558-9616

Tel: (514) 280-7804

Fax: (858) 588-9613

Fax: (514) 280-7805

E-mail: [email protected]

Web site: www.equi-vision.com

Web site: www.home.fda.net/~eci

President/CEO: Francois Fortier

President/CEO: R. Gil Carlyfc

R&D expertise: Strategic reflexion, technology transfer, startup. Coaching for corporate, team building, business development.

R&D expertise: Design, locate and buy used equipment (biotech, laboratory, pharmaceutical, research, production, etc.). Technological expertise: BME, BTC, PG

Technological expertise: TE, BI, BA, C/TC, HTDS, PG

Principal products/instrumentation: Biologicals, biomaterials, clinical tests, contract research/clinical trial products, instruments, reagents, vaccines, veterinary products.

Principal products/instrumentation: Biomaterials, contract manufacturing products, contract research/clinical trial products, organ transplants/culture products.

1068 EQUITECH-BIO, INC.

1070 ERGO SCIENCE, INC.

Add: 509 Cotton Gin Lane Kerrville, TX 78028-9377

Add: North Andover, MA 01845

Tel: (830) 257-0005

Fax: (978) 974-0633

E-mail: [email protected]

E-mail: [email protected]

Tel: (978) 974-9474

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Web site: www.ergo.com President/CEO: David R. Burt R&D expertise: Development and manufacture of proprietary pharmaceutical products to treat neuroendocrine disorders.

Sealed and granted patents: Magnetic messenger labeling technology.

1072 ERTEL ENGINEERING COMPANY

Key sales market contracts: Geneva Pharmaceuticals.

Add: P.O. Box 3358 Kingston, NY 12402

Technological expertise: G, CSDP

Fax: (845) 339-1603

Main products/instrumentation under R&D: ERGOSET™ for treatment of Type 2 diabetes, neuroendocrine resetting technology.

E-mail: [email protected]

Sealed and granted patents: Approximately 40 patents filed and/or issued relating to core neuroendocrine resetting technology.

1071 ERICOMP, INC. Add: 10211 Pacific Mesa Blvd., Ste. 411 San Diego, CA 92121 Tel: (858) 457-1888 Fax: (858) 457-2937

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Tel: (845) 331-4552

Web site: www.ertelengineering.com R&D expertise: Development and manufacture of filter systems and depth filter media for filtration of critical liquids. Technological expertise: P/S Principal products/instrumentation: Vapor Master Filter, Micro-Deck Filter Cartridge, Micro-Clear, Bio-Clean. Main products/instrumentation under R&D: Depth filter media for filtration of critical liquids, filter systems. Sealed and granted patents: VaporMaster, BioCleanPlate, SaniDeck Filter Housing.

E-mail: [email protected] Web site: www.ericomp.com President/CEO: Lonnie W. Adelman R&D expertise: Design, development, manufacture and marketing of precision microprocessorbased temperature cyclers, plastics, magnetic messenger labeling technology and pipettor centrifuges and chilling, incubators. Technological expertise: GA, CN/S, BME Principal products/instrumentation: SingleBlock™ System, Twin-Block™ System, PowerBlock I™ System, PowerBlock™ System, DeltaCycler I™ System, DeltaCycler II™ System, EasyTherm™ Chilling, incubator; Corning Costar Tubes, Plates, Pipettors and Centrifuges. Main products/instrumentation under R&D: Magnetic messenger labeling systems, precision microprocessor-based temperature cyclers.

1073 ESA, INC. Add: 22 Alpha Road Chelmsford, MA 01824 Tel: (978) 250-7000 Fax: 978 250-7090 Web site: www.esainc.com President/CEO: W. DiGiusto Research director: I. Acworth R&D expertise: Development of High Performance Liquid Chromatography (HPLC) products, research methods and services. Principal products/instrumentation: CoulArray® Detector; CouloChem® Detector; Vita Scan Methodology. Main products/instrumentation under R&D: HPLC-grade reagents, HPLC-grade solvent. Sealed and granted patents: Many.

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1074 ESCAGENETICS CORP.

1076 ESOX, INC.

Add: 1075 Bellevue Way, NE #605 Bellevue, WA 98004-4274

Add: 3864 Swanson Ct. Gumee JL 60031

President/CEO: Raymond J. Moshy, Ph.D.

Fax: (708) 336-6628

Research director: Walter E. Goldstein, Ph.D.

President/CEO: Thomas E. Palmer, Ph.D.

R&D expertise: Development and manufacture of pharmaceuticals, plant-derived products for the food processing industries.

R&D expertise: Custom research and production of biochemicals and biologicals; immunoassay development.

R&D collaboration: Liposome Technology, Inc. “Stealth” Taxol.

Technological expertise: E, P/S, BA, C/TC

Technological expertise: F, C/TC, RD, P/S, BA Principal products/instrumentation: True potato seed, ESCA-1 sweet corn. Main products/instrumentation under R&D: Taxol, “Stealth” Taxol, specialty starch corn, Phyto Vanilla™, date palm, plant-derived products for the food processing industries.

1075 ES INDUSTRIES

Tel: (708) 336-6600

Principal products/instrumentation: Reagents, cosmetics, contract research products, vaccines. Main products/instrumentation under R&D: Biologicals, biochemicals, immunoassay kits.

1077 ESPERION THERAPEUTICS, INC. Add: 3621 S. State St. 695 KMS Place Ann Arbor, MI 48108 Tel: (734) 332-0506

Add: 701 South Route 73 West Berlin, NJ 08091-2621 Tel: (856) 753-8400 Fax: (856) 753-8484 E-Mail: [email protected]

Fax: (734) 332-0516 E-mail: [email protected] Web site: www.esperion.com President/CEO: Roger Newton, Ph.D.

Web site: www.esind.com

R&D expertise: Pharmaceutical research and development/manufacture.

President/CEO: David A. KoWer

Key license and trade contracts: PNU.

Research director: Dr. Matthew Przybydel R&D expertise: Development and manufacture of specialty chemicals for chromatography. Technological expertise: SMC, COC, HTDS, P/S Principal products/instrumentation: Chromatography columns, Gammabond, Flurosep, AquaSep. Main products/instrumentation under R&D: Specialty chemicals for chromatography, chromatography media, chromatoplate.

Technological expertise: SMC, BI, DD, GA, HTDS, PG Main products/instrumentation under R&D: Contract research/clinical trials products, ApoA-1 Milano, preclinical; non-human animal apolipoprotein, lipid complexes. Sealed and granted patents: ApoA-1 Milano, Methods of using non-human animal apolipoprotein A-I protein, 6,953,840, U.S.; lipid complexes of ApoA-1 against compounds, 6,376,464, U.S.

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1078 ESSENTIAL CONSULTANTS, INC. Add: P.O. Box 80402 Atlanta, GA 30366-0402

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1080 EUROBIO

Tel: (770) 455-6492

Add: 7 Ave. de Scandinavie Les Ulis 91953 France

Fax: (404) 252-8394

Tel: 33 01 69 07 9477

President/CEO: K. Faer

Fax: 33 01 69 07 95 34

Research director: Dr. Mark Moskovitz

President/CEO: Pierre Reveilleau

R&D expertise: Separation technology development, related products manufacture. Technological expertise: BA, P/S Principal products/instrumentation: Contract manufacturing products, consulting services in separation technology. Main products/instrumentation under R&D: Separation-reaction-separation technology, separator, separating column.

1079 ETIOGEN PHARMACEUTICALS, INC.

Research director: Stephane Reveilleau R&D expertise: Development, production and marketing of reagents for molecular biology and cell biology. Technological expertise: Q, Y, T, PMC, LP, C/TC, GA, GT, P/S, RD, SY, PA Principal products/instrumentation: Biologicals, special chemicals, monoclonal antibodies, diagnostics, biomaterials. Main products/instrumentation under R&D: Reagents for molecular/cell biology research.

1081 EUROCLONE, LTD.

Add: 2462 Wyandotte Av. Mountain view, CA 94043

Add: 28 Victoria Street Paignton, Devon TQ4 5DN UK

Tel: (408) 223-8748

Tel: (39) 02-381-9534

Fax: (408) 223-0324

Fax: (39) 02-3391-0072

E-mail: [email protected]

E-mail: [email protected]

President/CEO: Kenneth W. Narducy

Web site: www.euroclone.net

Research director: John Wages

President/CEO: Franco Aiolfi

R&D expertise: Identification technique of new human etiologic agents; development and manufacture of diagnostic and therapeutic products.

Research director: Dr. Leo Izzi

R&D collaboration: CRADA with U.S. Naval Medical Research Center directed at hepatitis.

R&D expertise: Biotechnology medicines research, development and manufacture. Technological expertise: PA, RD, C/TC, GA, HTDS, PIS, P/S

Technological expertise: Q, BI, C/TC, SMC, SY, COC, D-D, GA, G, HTDS, PG, RD

Principal products/instrumentation: Genomic DNA/RNA purification and labeling medium for neuronal precursor cells (NS-A).

Main products/instrumentation under R&D: Contract manufacturing diagnostics, biopharmaceuticals, identification technique of human etiologic agents.

Main products/instrumentation under R&D: Plasmid DNA purification kit, plasmid DNA transduction kit, novel biotechnology medicines.

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Subsidiary bodies: European Distribution Center: Via Figino, 20/22, Pero, Milano, Italy 20016.

1082 EURO-DIAGNOSTICA B.V. Add: Beijerinckweg 18 Arnhem Netherlands Tel: (31) 26-363-0364 Fax: (31) 26-364-5111 E-mail: [email protected] Web site: www.eurodiagnostica.com President/CEO: M. Lundwall Research director: Dr. M. Salden R&D expertise: Development, production and sales of immunodiagnostica and other biotech drugs. Technological expertise: PA, RD, CB, C/TC, H/CF Principal products/instrumentation: Enzyme Immunoassays; Antibodies; RIAs; Peptide production. Contract manufacturing products, contract research/clinical trials products. Main products/instrumentation under R&D: EIA Kit for detection of rheumatoid arthritis, preclinical; HPV peptides for diagnostic use, carboxypeptidase B activating peptide. Sealed and granted patents: HPV peptides for diagnostic use, carboxypeptidase B activating peptide (CAPAP).

R&D expertise: Separations research, including downstream processing, production-sized chromatography columns 1 ft to 7 ft diameter, design and manufacture. Joint ventures: Amersham Pharmacia BioTech (APB). R&D collaboration: APB. Key sales market contracts: APB. Key license and trade contracts: APB. Technological expertise: CC, PMC, P/S, R, BA, CH/S, PIS, BP Principal products/instrumentation: Chromatography columns. Main products/instrumentation under R&D: Hollow fiber peek microfilters. Sealed and granted patents: Packing valve; ejector for packing column; lab columns; reverse phase media; hollow fiber peek microfilters.

1084 EUROGENTEC, S.A. Add: Parc Scientifique du Sart-Tilman Seraing B4102 Belgium Tel: (32) 43-660-150 Fax: (32) 43-655-103 E-mail: [email protected] Web site: www.eurogentec.com President/CEO: Prof. J. Martial Research director: Michel Thiry

1083 EUROFLOW (UK), LTD. Add: Unit 4, Brimscombe Port Business Park Brimscombe, Stroud, Glochestershire. GL5 2QN UK Tel: (44) 145-388-5774 Fax: (44) 145-388-3323 E-mail: [email protected] President/CEO: Gerry Spencer Research director: Dr. Martin Hofmann

R&D expertise: Bioprocess engineering products, peptide and instrumentation, biotechnology and biopharmaceuticals, process development and GMP manufacturing. R&D collaboration: Institut Pasteur de Lille/ CNRS/EBI-EMBL. Key sales market contracts: Babco, Glen Research. Key license and trade contracts: AmershamPharmacia Biotech, N Y Univ. (PHRI).

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Technological expertise: PA, RD, CS, SY, T, AT, BI, BP, C/TC, GA, F, GT, G, HF, PIS, P/S

Tel: (46) 18-480-4500

Principal products/instrumentation: Enzymes, monoclonal antibodies, DNA Array, Fluorescent Oligo, Transgenic and Knockout mice. Peptides for antibody production, photosphopeptides, labeled peptides, disulfide bridged peptides.

E-Mail: [email protected]

Main products/instrumentation under R&D: BILHVAX (schistosomiasis vaccine), Phase II; peptide sequencer, peptide synthesizer.

R&D expertise: Development and manufacture of clinically relevant tools that predict patients’ response to drugs, drug safety, disease stratification, prognosis of disease and outcome, and increased risk for disease.

Subsidiary bodies: Eurogentec UK Ltd. Abingdon.

Fax: (46) 18-480-4550 Web site: www.eurona.com President/CEO: Eugen Steiner, M.D., Ph.D. Research director: Tommy Lewander

R&D collaboration: NUTEK, Pyrosequencing and PGL. 1085 EUROMEDICA PLC Add: 7 Heron Quays London E14 4JB UK Tel: (44) 0 20-7536-7950 Fax: (44) 0 20-7538-8362 E-mail: [email protected] Web site: www.euromedica.com

Technological expertise: Q, BI, GA, G, PG Main products/instrumentation under R&D: Assay predicting response to antihypertensive treatment with ACE-inhibitors, pre-launch; Assays predicting response to antihypertensive treatment with other drug classes, clinical trials, clinically relevant tools that predict patient response to drugs.

President/CEO: Dr. Peter Woods, Group Managing Director Research director: Carina Sonnak

1087 EURO-PATH, LTD.

Subsidiary of Professional Staff PLC R&D expertise: Research of bioscience, pharmaceuticals and healthcare on a global basis, novel products development. Principal products/instrumentation: Healthcare drugs, contract R&D products. Main products/instrumentation under R&D: Healthcare medicine, bio-telescanner. Subsidiary bodies: Euromedica offices, including Cambridge, UK; Euromedica International Ltd., Paris, France; Frankfurt, Hamburg, Germany; Madrid, Spain; Brussels, Belgium; Mumbai, India.

1086 EURONA MEDICAL AB Add: Box 398 Uppsala SE-75106 Sweden

Add: Highland Comfort Union Hill Stratton, Bude, Cornwall EX23 9BL UK Tel: (44) 128-835-3686 Fax: (44) 128-835-2866 R&D expertise: Histopathology and immunology research of flow cytometry. Products development/manufacture. Key sales market contracts: Southern Biotechnology Associates, Inc. Novocastra Laboratories, Ltd., Euro-Diagnostics BV, Euro-Diagnostica AB, IQP. Technological expertise: PA, RD, GA, H/CF Principal products/instrumentation: Human leucocyte markers, p53 oncoproteins, dystrophin antibodies, human and rat CD markers, mouse CD markers.

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Main products/instrumentation under R&D: Flow cytometer, flow cell sorter.

1088 EUROPEAN COLLECTION OF CELL CULTURES Add: Porton Down Salisbury, Wilts SP4 OJG UK Tel: (44) 1980-61-2512

vectors, processing and genetic modification of hematopoietic cells. Technological expertise: P, G, C/TC, P/S, GT, G, BME Main products/instrumentation under R&D: Retroviral vectors for clinical trials, Phase II/ III; genetically modified hematopoietic cells for clinical trials, Phase II/III, cell and gene therapy products.

Fax: (44) 1980-61-1315 E-mail: [email protected]

1090 EUROSCREEN S.A.

Web site: www.camr.org.uk/ecacc.htm President/CEO: Dr. David Lewis Research director: Dr. Alan Doyle R&D expertise: Development and manufacture of pure, authenticated animal cell cultures and quality control.

Add: 802 Route de Lennik Brussels B-1070 Belgium Tel: (32) 2-529-0011 Fax: (32) 2-529-0019 E-mail: [email protected]

Technological expertise: F, C/TC, RD, P/S, H/CF

Web site: www.euroscreen.be

Principal products/instrumentation: Animal and human cell cultures, DNA probes, plant cell cultures, fetal calf serum.

Research director: M. Parmentier

Main products/instrumentation under R&D: Pure, authenticated animal cell cultures.

1089 EUROPEAN INSTITUTE FOR RESEARCH AND DEVELOPMENT OF TRANSPLANTATION STRATEGIES GMBH Add: Vollmersbachstrasse 66 Idar-Oberstein D-55743 Germany Tel: (49) 67-819-8550 Fax: (49) 678-198-5511 Web site: www.eufets.com President/CEO: Prof. A. A. Fauser, M.D., Ph.D.

President/CEO: Pierre Nokin R&D expertise: Development and products manufacture of functional genomics, identification of new receptors as novel targets for drug development; cloning and expression of nine protein coupled receptors (SPER). Technological expertise: Q, T, C/TC, GA, HTDS, RD Principal products/instrumentation: Contract research/clinical trial products, contract manufacturing products, Cell lines expressing SPCR; Membranes expressing SPCR; Acquorin cell lines for HTS. Main products/instrumentation under R&D: Identification of new receptors as novel targets for drug, protein coupled receptors.

1091 EUROSEQUENCE B.V.

Research director: H. G. Eckert, Ph.D. R&D expertise: R&D and manufacture of cell and gene therapy products, including viral

Add: Nyenborgh 4 Groningen 9747 AG Netherlands

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peptide, biochemical reagents, biochemical drug.

E-mail: [email protected] Web site: www.fwn.rug.nl/eurosequence President/CEO: H. J. Bak, Ph.D.; W. J. Weyer, Ph.D. Research director: W. J. Weyer, Ph.D. R&D expertise: Peptide instrumentation contract research, and development, analysis and synthesis of peptides/proteins and oligonucleotides.

1093 EVAX TECHNOLOGIES AKTIEN GESELLSCHAFT Add: Fraun Hofer Strasse 10 Martinsried 82061 Germany Tel: (49) 89-899-6740 Fax: (49) 89-899-67474 E-mail: [email protected]

Technological expertise: PIS, S, P/S, SY, P, PI, CS, P/PS

Web site: www.evax.de

Principal products/instrumentation: Protein chemistry, especially protein sequence analysis, characterization of recombinant proteins, custom peptide synthesis.

Research director: Dr. Kirstin Reissner

Main products/instrumentation under R&D: Peptide synthesizer, protein synthesizer, oligonucleotide synthesis.

1092 EUTECH SCIENTIFIC SVC, INC. Add: 810 North Second Av. Highland Park, NT 08904 Tel: (732) 249-1600

President/CEO: Dr. Martin Steiner R&D expertise: Development and manufacture of bacterial vaccines. R&D collaboration: Lohmann Animal Health. Technological expertise: F, BA, DD Main products/instrumentation under R&D: Helicobacter pylori vaccine, preclinical; otitis media vaccine, preclinical; acti-nobelillus/ pasteurella vaccine, preclinical (veterinary); Neisseria meningitidis vaccine, other bacterial vaccines. Subsidiary bodies: EP-A-0-540 525; EP-B-0 516 655; EP-B-0 291 021; PLCT/EP 97104560.

Fax: (732) 249-2806 E-mail: [email protected]

1094 EVOTEC BIOSYSTEMS AG

Web site: www.eutechsci.com President/CEO: Dr. Raghvendra Sahai Research director: Dr. Raghevendra Sahai R&D expertise: Contract research and manufacture of biotech medicines. R&D collaboration: Technical support, quality assurance set up with Scientific Resources, Inc. Application Support in Capillary Electrophoresis with Hewlett Packard.

Add: Schnackenburgaile 114 Hamburg 22525 Germany Tel: (49) 40-56-0810 Fax: (49) 40-56-081222 President/CEO: Dr. Karsten Henco Research director: Dr. Karsten Henco

Technological expertise: CC, P/S, CH/S, PMC

R&D expertise: Research of drug discovery, enzymes, analytical and diagnostic instruments and screening research services.

Main products/instrumentation under R&D: Contract research/clinical trial products, bioactive

Technological expertise: RD, D-D, BI, COC, DDI

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Main products/instrumentation under R&D: Functionally improved enzymes, analytical grade reagents, analytical chromatograph, analyzer for medicine concentration, diagnostic instruments.

1095 EXACT LABORATORIES, INC. Add: 63 Great Road Maynard, MA 01754 Tel: (978) 897-2800 Fax: (978) 897-3481 E-mail: [email protected] Web site: www.exactlabs.com President/CEO: Don M. Hardison Research director: Anthony P. Shuber R&D expertise: Development and manufacture of DNA-based screening test for early detection of cancer. R&D collaboration: Mayo Clinic, Rochester, MN; Creighton University, Omaha, NE. Technological expertise: G, DG, DK Main products/instrumentation under R&D: Proprietary genetic probes, DNA integrity assays, Clinical trials, DNA screening test for early detection of cancer.

Technological expertise: C/TC, P/S, H/CF Principal products/instrumentation: ANTIBODY REAGENTS, including: G-Protein Coupled Receptors, Apoptosis, Ion Channels, Membrane Trafficking, Protein Expression Tags, Signal Transduction, Cell Lysates, Membrane Receptors, Transcription Factors, Protein Kinases, Tumor Suppressors, Protein Phosphatases, Signaling Intermediates, Cell Cycle, Oncoproteins, Infectious Agents, Cytokines and Cytokine Receptors, Neurobiology, Miscellaneous Antibody Reagents, MB Bacteriophage Antibodies. FLOW CYTOMETRY REAGENTS, including: Single Color: FITC, RPE, APC, Cy5RPE, Biotin, Three Color FITC/RPE/Cy5RPE, Bitest Two Color Reagents FITC/RPE, DNA Ploidy Analysis Kits, NuParaffin Nuclei Extract Kits, Leukemia Phenotyping Reagents, Quick Lyse RBC Lysing Solutions, Second Step Antibody Reagents, Negative Controls for Single Color Reagents. Main products/instrumentation under R&D: Cell/tissue cultures, monoclonal/polyclonal antibodies, flow cytometry products, test kits, drug discovery route.

1097 EXELIXIS, INC. 1096 EXALPHA BIOLOGICALS, INC.

Add: 170 Harbor Way, P.O. Box 511 So. San Francisco, CA 94083-0511

Add: 20 Hampden Street Boston, MA 02119

Tel: (650) 837-7000 or 837-7277

Tel: (800) 395-1137

Fax: (650) 837-8300

Fax: (617) 989-0404

E-mail: [email protected]

E-mail: [email protected]

Web site: www.exelixis.com

Web site: www.exalpha.com

President/CEO: George Scangos, Ph.D.

President/CEO: John M. Castracane

Research director: Geoffrey Duyk, M.D., Ph.D.

Research director: Jaime Maturana R&D expertise: R&D of cell and tissue culture, monoclonal and polyclonal antibodies, flow cytometry products, test kits, diagnostic products and drug discovery research products.

R&D expertise: Development, manufacture and commercialization of functional genomics; model system genetics/comparative genomics. Joint ventures: Genoptera.

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R&D collaboration: Pharmacia, Bayer, Bristol-Myers, Squibb, Dow Agro-Sciences. Key license and trade contracts: Several technology related licenses and gene families implicated in human disease. Technological expertise: P/S, RD, R, Q, SMC, SY, AF, AB, BI, GA, G, HTDS, PG Main products/instrumentation under R&D: Contract development of drug products, commercialization of functional genomic marker, model system gene/comparative genome; XL184 demonstrated activity in patients with previously treated glioblastoma multiforme, according to updated phase II trial data, 2009. Sealed and granted patents: Sulfs as modifiers of the beta-catenin pathway and method of use. 20080050313, U.S.

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Principal products/instrumentation: Contract manufacturing products LNA™, Locked nucleic acid, novel DNA analogue, Immobilizer™ pre-activated microplates and strips, VetScreen™ salmonella covalent tnixdisa, BAM-Pesticide Covalent Eisa. Main products/instrumentation under R&D: Bioarrays and chips for SNP detection, preclinical; Antisense drugs (target validation), preclinical; novel nucleic acid assay technologies, photochemical immobilization of biomolecules. Sealed and granted patents: Photochemical immobilization of biomolecules, numerous patents pending for locked nucleic acid in target validation and antisense, diagnostic applications.

1099 EXOCELL, INC. 1098 EXIQON A/S Add: 9 Bygstubben Vedbaek Copenhagen DK2950 Denmark

Add: 3508 Market St., Suite 420 Philadelphia, PA 19104 Tel: (215) 222-5515

Tel: (45) 45-66-0888

Fax: (215) 222-5325

Fax: (45) 45-66-1888

E-mail: [email protected].

E-mail: [email protected]

President/CEO: M.P. Cohen

Web site: www.exiqon.com

Research director: V. Y. Wu

President/CEO: Mikael Oerum Research director: Mogens H. Jakobsen

R&D expertise: Diabetes management and complications.

R&D expertise: Development and manufacture of novel nucleic acid based assay technologies for detection of disease susceptibility genes.

R&D collaboration: Japanese Pharmaceutical Co.

R&D collaboration: Copenhagen Hospital Board (Single-base mutation assays and bioarrays, chips). Key sales market contracts: Flowgen/Novara (Immobilizer™), Genaxis (Irnmobilizer™), Svanova Biotech (VetScreen™). Key license and trade contracts: W. Nalge/Nunc (USA, Denmark), IMNT (Germany), Genovision (Norway), Proligo LLC (USA, Germany). Technological expertise: CC, AB, C/TC, D-D, GT, G, HTDS, H/CF, P/S, PG, PA, R, Q, Y

Key license and trade contracts: Cortecs International; Summit Pharmaceuticals. Technological expertise: C,/TC, HTDS, H/CF Principal products/instrumentation: Diagnostics for diabetes management (Glycaben, Albuwell, Hemaben, Glycacor), immunoassay products, reagents, reference standards, monoclonal antibodies and other products for management of diabetes mellitus and its complications; monoclonal antibody production on special contract, specialized immunoassays for investigational studies.

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Main products/instrumentation under R&D: Afif for diabetic microvascular complications, Phase I; EXO-226 for nephropathy, Phase II/III. Sealed and granted patents: Numerous for therapeutics/diagnostics regarding glycated proteins in diabetes; immunopathogenesis of diabetes.

1100 EXON-INTRON, INC.

Main producs/instrumentation under R&D: Biologicals, contract manufacturing products, contract research/clinical trial products, gene expression profiling, protein purification treatment.

1102 FAST SYSTEMS, INC. Add: 8-5 Metropolitan Court Gaithersburg, MD 20878

Add: P.O. Box 475 Stewartstown, PA 17363

Tel: (301) 977-0536

Tel: (717) 993-5511

Fax: (301) 977-7023

E-mail: [email protected]

E-mail: [email protected]

Web site: www.dnatech.com

Web site: www.fastsys.com

President/CEO: Robert E. Farrell, Jr., Ph.D.

President/CEO: M. J. Waxdai, Ph.D.

R&D expertise: Biotechnology medicines research and manufacture.

Research director: U. J. Waxdai, Ph.D.

Technological expertise: AB, RD, P/S, GA, C/TC Principal products/instrumentation: Contract research/clinical trial products, laboratoryintensive biotechnology training programs; lab support services. Main products/instrumentation under R&D: Biotech drug, biotherapeutics.

1101 EXPRESSGEN INC. Add: CTP Research Center 2201 West Campbell Park Dr. Chicago, IL 60612-3501

R&D expertise: GLP laboratory research for drug preclinical studies; licensed reference lab for clinical studies; flow cytometry, QA programs, human and animal chromosomes. Technological expertise: P/S, C/TC, GT Principal products/instrumentation: Contract research/clinical trial products, in vitro toxicology testing method, chromosomes; Flow cytometry services; Cell lines. Main products/instrumentation under R&D: Flow cytometer, human and animal chromosomes.

1103 FEMTO CALIBRATIONS

Tel: (312) 733-8799 Fax: (312) 733-8854 E-mail: [email protected] Web site: www.expressgen.com President/CEO: Robert S. Danziger, M.D. R&D expertise: Contract research services for molecular biology, gene expression and protein purification. Technological expertise: E, F, RD, C/TC, GA, P/S

Add: 1492 Morris Ave. Main Floor Ste. Union, NJ 07083 Tel: (908) 964-4777 Fax: (908) 964-0970 Web site: www.femtocal.com President/CEO: Sanjay Saxena R&D expertise: Development and manufacture of lab equipment. Technological expertise: BME

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Principal products/instrumentation: Femto Eminence pipets™, pipet tips, PCR tubes, microtubes, screw cap tubes, racks, wipes.

Key license and trade contracts: PCR products, sequencing products.

Main products/instrumentation under R&D: Laboratory drug information management system, labwares, laboratory reagents, computer aided drug research.

Principal products/instrumentation: Molecular biology products, MBI Fermentas.

Technological expertise: F, P/S

Main products/instrumentation under R&D: Molecular sieve carrier, molecular drug design, molecular biology research reagents.

1104 FERMELO S.A. Add: Terranova 150 of. 1 Providencia, Santiago Chile

1106 FERMENTAS, INC.

Tel: (56) 247-2976

Add: A-7520 Connelley Dr. Hanover, MD 21076

Fax: (56) 247-2978

Tel: (905) 333-8355

E-mail: [email protected]

Fax: (905) 333-3135

President/CEO: Ludano Fernandez

E-mail: [email protected]

Research director: Valeska Volrath

Web site: www.fermentas.com

R&D expertise: Research of molecular biology, fisiology, and biochemistry related products development.

President/CEO: Andrew Cerskus, Ph.D.

Technological expertise: GT, P/S, P/S, RD, SMC, Q, T, CB, C/TC, GA Main products/instrumentation under R&D: Biologicals, biomaterials, specialty chemicals, reagents, contract manufacturing products, molecular drug design, biochemical medium, molecular biology research reagents.

1105 FERMENTAS AB Add: Graiciuno 8 Vilnius LT-2028 Lithuania Tel: (370) 2-60-2131 Fax: (370) 2-60-2142 E-mail: [email protected] Web site: www.fermentas.com

Research director: Alex Yu, Ph.D. R&D expertise: Development and manufacture of molecular biology research reagents. Joint ventures: Fermentas AB, Vilnius Lithuania. Key sales market contracts: Euromedex. Technological expertise: Q, GA, GT, PG, RD Principal products/instrumentation: Restriction enzymes, Tag polymerase, DNA/RNA modifying enzymes, DNA molecular weight markers. Main products/instrumentation under R&D: Molecular biology research reagents, nucleosidase, nucleotidase, DNA gyrase, DNA helicase, DNA ligase. Subsidiary bodies: 7 Innovation Dr., Flamborough, Ontario, L9H 7H7 Canada.

President/CEO: Dr. Viktoras Butkus Research director: Algirnantas Markauskas R&D expertise: R&D of molecular biology products.

1107 FERMENTATION ENG., INC. Add: 501 S. Parallel Ave. Ripon, CA 95366

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Tel: (209) 599-7157

1109 FERMPRO MANUFACTURING LP

Fax: (209) 599-2137 President/CEO: Gordon M. Armstrong

Add: Highway 52 North Kingstree, SC 29556

R&D expertise: Development and related products manufacture of systems integration, computer process control and data acquisition.

Tel: (843) 382-8485

Key sales market contracts: Rockwell-Chow GmbH, Extruder system design.

President/CEO: James W. Godfrey

Fax: (843) 382-8676 Web site: www.fermpro.com

Key license and trade contracts: Aeration System/Chiron Corp.

R&D expertise: Development and manufacture of contract manufacturing products — large-scale fermentation processes.

Technological expertise: BA, PMC, CH/S

Technological expertise: F, P/S

Principal products/instrumentation: Next art medical tubing extrusion systems.

Main products/instrumentation under R&D: Contract manufacturing products, large-scale fermentation processes, large-scale preparation for fermentation.

Main products/instrumentation under R&D: Beta-Glucan, Lycopene. Sealed and granted patents: Eductor aeratron, rotary flow balanced die.

1110 FERMTECH, INC. Add: P.O. Box 317 Mount Airy, MD 21771

1108 FERMENTEK, LTD. Add: P.O. Box 47120 Jerusalem 97800 Israel Tel: (972) 2-585-3953 Fax: (972) 2-585-3943 E-mail: [email protected] Web site: www.fermentek.co.il President/CEO: Dr. Yosef Behrend Research director: Dr. Yosef Behrend R&D expertise: Development and production of biopharmaceutials, biochemicals and natural products for the research market.

Tel: (410) 875-2968 Fax: (410) 635-2471 E-mail: [email protected] Web site: www.fermtechinc.com President/CEO: Bing Miller R&D expertise: Development and manufacture of biosensors. Technological expertise: F, BA, C/TC, PMC, BME Principal products/instrumentation: Biosensors, contract manufacturing products, oxygen sensors, fermentation accessories, carbon dioxide sensors, carbon monoxide sensors.

Technological expertise: F, P/S, SMC Principal products/instrumentation: K252a and derivatives, Forskolin, Paclitaxel, Mycophenolic acid, Actinomycin D, Staurosporine etc. Main products/instrumentation under R&D: Rapamycin, valinomycin, specialty chemicals, natural products for the research market.

1111 FIBERCOR — DIVISION OF MINNTECH CORPORATION Add: 14605 28th Ave., North Minneapolis, MN 55447 Tel: (800) 328-3370 Fax: (612) 553-3387

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E-mail: [email protected] Web site: www.minntech.com President/CEO: Bill Hope (interim) Research director: Mike Peterson R&D expertise: Development, manufacture and marketing of medical devices, sterilants, and water purification products. Technological expertise: E, P/S, BA Principal products/instrumentation: Organ transplants/culture products, Renalin, Renasol, Centrisol, Nephrosol, Fiberflo, Actril, Minncare, Minnclean, Biocor, Aer Plus, Renatron, Peract 20. Main products/instrumentation under R&D: Novel medical devices, sterilants, water purification agent, sterilizer, sterilization filter.

1112 FIBROGENEX, INC. Add: 2201 W Campbell Park Dr. Chicago, IL 60612 Tel: (312) 666-1501 President/CEO: Ralph H. Silverman Research director: Clyde R. Goodheart R&D expertise: Development and manufacture of biopharmaceuticals. Technological expertise: P/S, C/TC Main products/instrumentation under R&D: Periodontal treatment, Phase II/III; biotech drug, biotin enzymes, biotherapeutics, cellular fibronectin. Sealed and granted patents: Use of cellular fibronectin for treating chronic degenerative disease, use of cellular fibronectin to inhibit local recurrence of cancer, method for preparing cellular fibronectin,

1113 FIBROGEN, INC. Add: 409 Illinois St., San Francisco, CA 94158 Tel: (415) 978-1433 Fax: (415) 978-1452

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E-mail: [email protected] Web site: www.fibrogen.com President/CEO: Thomas Neff Research director: George R. Martin, Ph.D. R&D expertise: Development and manufacture of recombinant collagen and recombinant gelatin, anti-fibrotic therapeutics, tissue repair and regeneration. R&D collaboration: ArQule (anti-fibrotics); PPL Therapeutics (Rh collagen); Medarex. Key license and trade contracts: Zeneca (anti-fibrotics). Technological expertise: TE, T, D-D, GT, HTDS, RD, SMC, F Main products/instrumentation under R&D: Recombinant collagen, fows: supply, scale-up; collagen synthesis inhibitors, preclinical; Cytokine inhibitors, preclinical; Human neutralizing antibodies, preclinical; Multigene method, Rh collagen, recombinant gelatin, anti-fibrotic therapeutics, tissue repair and generation program; Phase II trial of FG-3019, a fully human monoclonal antibody targeting connective tissue growth factor (CTGF), in patients with type II diabetes who have advanced diabetic kidney disease, 2009. Subsidiary bodies: Oulu, Finland; Durham, NC, USA. Sealed and granted patents: Multigene method, Rh collagen compositions, target collagen assembly, enzymes and cytokines, CTGF compositions, expression, methods for wound healing; connective tissue growth factor (CTGF) and methods of use. 6,358,741, U.S.; Recombinant gelatins. 6,992,172, U.S. 1114 FIELD-TEST TECHNOLOGY, LTD. Add: 66 The Crescent, Marston Oxford, Oxon 0X3 OJN UK Tel: (44) 1865-791256 Fax: (44) 1865-792421 E-mail: [email protected]

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Web site: www.field-test.co.uk

Fax: (44) 107-251-7778

President/CEO: Richard Fielder

President/CEO: Richard Cooper

R&D expertise: Development of test kits for GM food detection and consultancy on food safety.

Research director: Dr. Mike Bedford

Key sales market contracts: Hanse-Annestik GmbH, Immunolab, GmbH. Technological expertise: C/TC, DK Principal products/instrumentation: Test kits for GM food detection, food processing products. Main products/instrumentation under R&D: Detection kits for food poisoning.

1115 FINECHEM GMBH

Subsidiary of Cultor R&D expertise: Development and manufacture of animal feed enzymes. Technological expertise: E, ET, EAT Principal products/instrumentation: Avizyme™, Porzyme™. Sealed and granted patents: Phytase from bacillus subtilis, gene encoding said phytase, method for its production and use. 6,638,746, U.S.

1117 FINNZYMES, OY. (LTD)

Add: Hauptstr. 56 Sigmarszell D-88138 Germany

Add: P.O. Box 148 Espoo 02201 Finland

Tel: (49) 83-899-2040

Fax: (358) 9-58-41-2200

Fax: (49) 838-992-0430.

E-mail: [email protected]

President/CEO: Dr. Wolfgang Golla

Web site: www.finnzymes.fi

R&D expertise: Development and manufacture of fine chemicals for biochemistry, biotechnology, microbiology, clinical chemistry etc. applications.

President/CEO: Pekka Mattila

Technological expertise: SMC, SY Principal products/instrumentation: Contract manufacturing products, Chromogenic, fluorogenic, chemiluminescent, organic chemical specialties etc. Main products/instrumentation under R&D: Fine chemicals, fine granule.

1116 FINNFEEDS INTERNATIONAL, LTD. Add: Market House, Ailesbury Ct. High St. Marlborough, Wiltshire SN8 1AA UK Tel: (44) 107-251-7777

Tel: (358) 9-58-4121

Research director: Pekka Mattila R&D expertise: Development and manufacture of DNA and RNA modifying enzymes, sequencing enzymes, proteinase, alkaline phosphatase. Joint ventures: New England Biolabs. R&D collaboration: Genis-Iceland, New England BioLabs. Technological expertise: Q, GA, E, ET Principal products/instrumentation: Dynazyme™ thermostable, DNA polymerase, DNA size markers, Alkaline phosphatase, Proteinase K, AMV reverse transcriptase. Main products/instrumentation under R&D: Sequencing enzymes, terminal transferase, DNA and RNA modifying enzymes, sequencing enzymes, nuclease, nucleophosphatase.

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1118 FIRST LINK (UK), LTD. Add: Unit 18, The Premier Estate Leys Road, Brierley Hill West Midlands DY5 3UP UK Tel: (44) 0 1384-263-862 Fax: (44) 0 1384-480-351

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R&D expertise: Diagnostic system development. Technological expertise: E, P/S, R, H/CF, CH/S, SY Main products/instrumentation under R&D: Point of core diagnostic systems, diagnostic reagents, diagnostic enzymes, diagnostic kits.

Research director: Dr. Y. Goward R&D expertise: Cell and tissue culture development, manufacturer of biological reagents from natural sources.

Add: 1316 18th St. Two Rivers, WI 54241

Technological expertise: P/S, LP, C/TC, H/CF

Tel: (920) 793-1121

Principal products/instrumentation: Biologicals, chemicals, contract manufacturing products, diagnostics, in vitro toxicology testing products, organ transplants/culture, reagents, serum albumins from human, bovine, ovine and porcine sera; raw and sterile sera and plasmas (fetal bovine, newborn bovine and adult bovine, ovine, porcine, goat, rodent, human sexed, typed etc.); bovine pituitary extract for serum-free keratinocyte growth; rat tail collagen type I solution for matrix formation; Endothelial Cell Growth Supplement for primary angiogenic cell growth; GMEM medium for selective growth of CHO cells containingglutamine synthetase expression system; Recombinant human, murine and rat growth factors and also their monoclonal and polyclonal antibodies.

Fax: (920) 794-6478

Main products/instrumentation under R&D: Cell and tissue culture, biological reagents from natural sources.

1120 FISHER HAMILTON, LLC.

Web site: www.fisherhamilton.com President/CEO: J. Michael Brown Research director: John Bastian R&D expertise: Development and manufacture of laboratory furniture and fume hoods for novel drug research. Technological expertise: BME Principal products/instrumentation: Wood, steel and plastic laminate fixed height casework systems; MAX/LAB adaptable furniture systems; SafeAire fume hoods. Main products/instrumentation under R&D: Laboratory furniture, fume hoods, laboratoryscale purification devices.

1121 FISHER SCIENTIFIC Add: 2000 Park Ln. Pittsburgh, PA 15275 Tel: (412) 490-8300

1119 FIRST MEDICAL, INC.

Fax: (412) 490-1725 E-mail: [email protected]

Add: 530 Logue Ave. Mountain View, CA 94043 Tel: (650) 903-5974 Fax: (650) 903-9040 President/CEO: David C. McCaslin Research director: Michael Cobb

Web site: www.fishersci.com President/CEO: Phillip T. Vogel Subsidiary of Fisher Scientific International Inc. R&D expertise: Development and manufacture of instruments, apparatus and chemicals

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for industrial, clinical, medical research, government and educational labs. Key sales market contracts: Promega Corp., enzymes; Cruachem, DNA synthesis reagents; Applied Immune Sciences, cell-selecting devices. Technological expertise: BME, E, ET Principal products/instrumentation: MicroProbe™ immunostainer, FisherBiotech™ reagents, FisherBiotech™ electrophoresis systems. Main products/instrumentation under R&D: DNA synthesis reagents, cell-selecting devices, diagnostic enzymes, instruments/apparatus/ chemicals for drug research. Subsidiary bodies: U.S. branches: Atlanta, GA; Baton Rouge, LA; Itasca, IL; Cincinnati, OH; Piano, TX; Denver, CO; Houston, TX; Tustin, CA; Springfield, NJ; Orlando, FL; Malvern, PA; Pittsburgh, PA: Cayey, PR; St. Louis, MO; Santa Clara, CA; Canada: Edmonton, AB; Vancouver, BC; Montreal, PQ; Ottawa, ON; Unionville, ON; International: UK, Singapore; Manufacturing: AR, CT, NJ, NY, PA.

1122 FITZCO, INC. Add: 5600 Pioneer Creek Dr. Maple Plain, MN 55359 Tel: (612) 479-3489 Fax: (612) 479-2880 E-mail: [email protected] Web site: www.fitzcoinc.com President/CEO: June Fitz Research director: R. Luedke R&D expertise: Research and products development of specimen collection, transport, storage and processing for PCR; kit manufacture. Key sales market contracts: Life Technologies, Inc. — FTA™ GeneGuard product line (exclusive).

Technological expertise: T, Q, GA, P/S, R Principal products/instrumentation: FTA™ GeneGuard System, Home Access™ HIV Home Test Kit (Florae Access, Inc.). Main products/instrumentation under R&D: FTA related; DNA preparation and storage — automated; crime scene collection materials, transport/storage and processing for PCR. Sealed and granted patents: FTA™ and related.

1123 FITZGERALD INDUSTRIES INTERNATIONAL, INC. Add: 34 Junction Square Drive Concord, MA 01742-3049 Tel: (978) 371-6446 Fax: (978) 371-2266 E-mail: [email protected] Web site: www.fitzgerald-fii.com President/CEO: Kevin J. Fitzgerald R&D expertise: Research, development and manufacture of diagnostic reagents — 5,000 monoclonal and polyclonal antibodies and purified antigens; bioprocess engineering products. Technological expertise: C/TC, CH/S, PA, PMC, LP, RD, H/CF, E Principal products/instrumentation: Monoclonal and polyclonal antibodies; purified antigens, affinity purified antibodies, precipitating antibodies, custom standards and calibrators, conjugates and precursors, purified immunoglobulins, chromogenic substrates, enzyme labeled antibodies, normal and disease state sera/plasma, custom monoclonal and polyclonal antibody production, specialty chemicals. Main products/instrumentation under R&D: Thyroid peroxidase, recombinant; diagnostic reagents, including 5,000 monoclonal/polyclonal antibodies and purified antigens.

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1124 FLAMEL TECHNOLOGIES

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Tel: (61) 8-08-201-2088 Fax: (61) 8-08-201-2988

Add: Pare Club Du Moulin A Vent 33 Av. Dr. G. Levy Venissieux 69693 France Tel: (33) 47-278-3434 Fax: (33) 47-278-3435 E-mail: [email protected] Web site: www.flamel.com President/CEO: Dr. Gerard Soula Research director: Dr. Gerard Soula R&D expertise: Technology development of protein delivery and drug delivery related products manufacture. R&D collaboration: Searle, Monsanto, Corning, Novo-Nordisk. Key sales market contracts: Searle, Monsanto, Corning, Novo-Nordisk. Key license and trade contracts: Searle, Monsanto, Corning, Novo-Nordisk. Technological expertise: DD, D-D Principal products/instrumentation: Trademarks, including Medusa, Micropump™, Basulin™, Asacard™. Main products/instrumentation under R&D: Asacard™ CV aspirin, Long-Acting Acyclovir, Phase III; Long-acting Insulin, preclinical; Long-acting formulations of other proteins (R&D); ASACARD™, CV Aspirin approved in nine European countries; controlled release of Acyclovir C Genvir: positive result of Phase III; Long-acting insulin: proof of concept on Phase I study; long-acting interferon: R&D. Sealed and granted patents: Various — over 30.

1125 FLINDERS TECHNOLOGIES PTY, LTD. Add: The Flinders University of South Australia Bedford Park, South Australia 5042 Australia

President/CEO: Dr. John V. Turner R&D expertise: Development and commercialization of drug research projects and intellectual resources of Flinders University. Joint ventures: Wide range of commercial arrangements with both domestic and overseas organizations under a variety of legal structures. Technological expertise: E, RD, GT, P/S, GA, R, H/CF, C/TC, CH/S, SY Principal products/instrumentation: Enzymic reagents for measuring ions (sodium and potassium) through Boehringer Mannheim, material for safe collection of body fluids through Fitzco, Inc. Main products/instrumentation under R&D: Isolation of fetal cells for prenatal diagnosis, preclinical; Lymphometer for measuring swelling, Phase I; Toxoplasma recombinant antigens for diagnosis, preclinical.

1126 FLOW CYTOMETRY STANDARDS CORP. Add: P.O. Box 194344 San Juan, Puerto Rico 00919 Tel: (809) 753-9341 Fax: (809) 758-3267 President/CEO: Dr. A. Schwartz Research director: Dr. A. Schwartz R&D expertise: Development and manufacture of microbead standards for calibration of flow cytometers and other scientific and clinical instruments. Technological expertise: CH/S, SY, BME Principal products/instrumentation: Quantum fluorescence kits; Quantum Simply Cellular; QC3™; QC Windows™; QuickCal Program.

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Main products/instrumentation under R&D: Flow cytometers, scientific/clinical instruments.

1127 FLOWGEN, LTD. Add: Novara House, Ashby Park Ashby De La Zouch Leicestershire LE65 ING UK

R&D collaboration: SBIRI and II. Technological expertise: E, COC, P/S, R, H/CF Principal products/instrumentation: MALSTAT™, diagnostic and C/S tests for malaria. Main products/instrumentation under R&D: Malaria diagnosis of Rx, therapeutic biopharmaceuticals.

Tel: (44) 153-041-8000 Fax: (44) 153-041-8260 E-mail: [email protected]

1129 FLUID MANAGEMENT SYSTEMS, INC.

Web site: www.flowgen.co.uk President/CEO: Richard Chapman R&D expertise: Technology development of electrophoresis, chromatography, downstream processing, molecular biology, filtration (ultra and micro), related products manufacture.

Add: 56 Felton St. Waltham, MA 02453 Tel: (781) 891-6522 Fax: (781) 891-6665 Web site: www.fms-inc.com President/CEO: Hamid Shirkhan

Technological expertise: F, E, RD, P/S, BA, H/CF, C/TC, G, HTDS

R&D expertise: Environmental bioprocess engineering products.

Principal products/instrumentation: Power supplies, transilluminatories, precast gels, filtration equipment, pumps, biochromatography media, gel apparatus, DNA agaroses.

Technological expertise: P/S, LP, BA

Main products/instrumentation under R&D: Electrophoresis apparatus, chromatography column, downstream processing, molecular biology research reagents, filtration manifold.

1128 FLOW, INC. Add: 6127 S.W. Corbett Portland, OR 97201

Principal products/instrumentation: PowerPrep Sample Cleanup System, Dioxin-Prep Sample Cleanup System, GPC-Prep Sample Cleanup System, Auto-Sep Protein Purification System. Main products/instrumentation under R&D: Environmental bioprocess engineering bacteria.

1130 FLUOR DANIEL, INC.

Tel: (503) 246-2710

Add: 1 Fluor Daniel Dr. Aliso Viejo, CA 92698-1000

Fax: (503) 245-7666

Tel: (714) 975-2000

E-mail: [email protected]; MikeatFlow@ aol.com

Fax: (714) 975-5981

Web site: www.malariatest.com President/CEO: M. T. Makler, M.D. Research director: M. T. Makler, M.D. R&D expertise: Development of malaria diagnosis and Rx; related therapeutical biopharmaceuticals manufacture.

President/CEO: Leslie McCraw R&D expertise: Research and development of engineering, gene construction, validation and maintenance for pharmaceutical and biotech industries; products manufacture. Technological expertise: RD, F, P/S, BA, C/TC, PMC, SY, DD

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Main products/instrumentation under R&D: Contract development products, engineering cell, gene construction. Subsidiary bodies: Greenville, SC; Marlton, NJ.

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Main products/instrumentation under R&D: Immunomodulatory/stimulatory adjuvants and oncologic agents, topical anti-fungals and antipsoriatic agents, medical devices.

1133 FORBES MEDI-TECH, INC. 1131 FONA DIAGNOSTICS INTERNATIONAL, INC.

Add: 1066 West Hastings St. Suite 2000 Vancouver, BC V6E 3X2 Canada

Add: 855 Matheson Blvd. East Unit 14 Mississauga, Ontario L4W 4L6 Canada

Tel: (604) 689-5899

Tel: (905) 625-4510

Web site: www.forbesmedi-tech.com

Fax: (905) 625-2434

President/CEO: Tazdin Esmail

President/CEO: Jeanne Feather

Research director: Dr. James Kutney and Dr. Egon Novak

R&D expertise: Development and manufacture of Elisa and DNA diagnostic kits. Technological expertise: C/TC, P/S, H/CF Principal products/instrumentation: ELISA assays for autoimmune, coagulation, neuropsychiatric and virology applications, ANA kits and slides. Main products/instrumentation under R&D: Elisa and DNA diagnostic kits.

Fax: (604) 689-7641

R&D expertise: Research, development, design, manufacture and commercialization of valuable pharmaceutical products derived from forest industry by-products, specifically cholesterol lowering agents and steroid drugs. R&D collaboration: Slovakofarma, Slovakia; Antibiotic Co., Bulgaria. Key license and trade contracts: University of British Columbia. Technological expertise: C, F, CB, P/S, SY

1132 FOOD, DRUG, CHEMICAL SERVICES Add: 7925 Meadow Rush Loop Sarasota, FL 34238 Tel: (941) 925-8958 Fax: (941) 926-9615 E-mail: [email protected]

Main products/instrumentation under R&D: IND for Phase II trials submitted to FDA; forest industry by-products, cholesterol lowering agent, steroid drugs. Sealed and granted patents: CARDIOREX™ — extraction and purification process, indication and use, composition cardiovascular risk marker.

President/CEO: Bob West, Ph.D. Research director: Bob West, Ph.D.

1134 FORGENE, INC.

R&D expertise: Research development and regulatory consultants to drug, biotechnology, and medical device industries, related products of development and manufacture.

Add: 549 Eagie St. P.O. Box 1370 Rhinelander, WI 54501

Technological expertise: BME, AF, BTS

President/CEO: Neil D. Nelson, Ph.D.

Tel: (715) 365-8733

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Research director: Neil D. Nelson, Ph.D. R&D expertise: Development, manufacture and commercialization of genetically improved trees and new genetic technologies for tree crops using genetics and biotechnology. R&D collaboration: WI Department of Development/University of Wisconsin; Consolidated Papers, Inc.; U.S. Forest Service.

Technological expertise: F, PA, SMC, AB, BA, C/TC, DD, P/S, RD Main products/instrumentation under R&D: Biologicals, contract manufacturing products, contract research/clinical trial products, natural products, pharmaceuticals, vaccines, veterinary products, cell culture/fermentation tube, lyophilized culture, lyophilizer.

Technological expertise: C/TC, G, PG, CB Principal products/instrumentation: INSTITREES™ Hybrid Poplars, FORGENE ELITE™ White Spruce Hybrids, COLDPRUF Norway Spruce, FORGENE ELITE™ Balsam Fir Hybrids, FORGENE NORTHERN LIGHTS™ Birch. Main products/instrumentation under R&D: Genetically improved tree, new genetic technologies for tree crops, cell and tissue culture/ clonal propagation/breeding trees and shrubs (woody plants). Sealed and granted patents: U.S. patent No. 5,304,725 ELITE white spruce hybrids and method of production, 1994.

1135 FORMATECH, INC.

1136 FORTRON BIO SCIENCE, INC. Add: 108 Nova Dr. Morrisville, NC 27560 Tel: (919) 380-1778 Fax: (919) 380-1799 E-mail: [email protected] President: Richard Wicks Research director: Dr. Ann Black R&D expertise: Development, design, manufacturing and market of antibody and antigen components for diagnostic test kits. Joint ventures: Biospacific, Inc. — antibodies and antigens. R&D collaboration: Biospacific, Inc. cardiovascular and neurological disease markers. Technological expertise: PA, P/S, BI, G, PMC

Add: 175 Cabot St. Lowell, MA 01854 Tel: (978) 970-0300 Fax: (978) 970-3435 E-mail: [email protected] Web site: www.formatech.com President/CEO: Benjamin Isaacs, Ph.D. Research director: Indu Isaacs, Ph.D. R&D expertise: Contract biopharmaceutical product development, formulation development, dosage form development, lyophilization development, pre-formulation/characterization, cell culture/fermentation development, purification/process development, analytical methods development, stability programs, clinical supply final dosage manufacture.

Principal products/instrumentation: Antibodies for cardiac markers, hormones, immunoglobulins. Main products/instrumentation under R&D: New markers for cardiovascular and neurological disease, antibody and antigen components for diagnostic test kits, troponin I antibodies, cardiovascular and neurological disease markers. Sealed and granted patents: U.S. 5,756,682, 5,834,220 (Troponin I Antibodies).

1137 FORTUNE BIOLOGICALS, INC. Add: 18919 Premiere Ct. Gaithersburg, MD 20879

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Technological expertise: F, RD, T, P/S, BA, H/CF, C/TC, PMC, CH/T.S, SY Main products/instrumentation under R&D: Contract development products, process plants engineering for biotechnology industries.

President/CEO: E. W. May Research director: Daniel J. Lamb R&D expertise: Contract R&D and manufacture of human and animal derived biologicals, preparation of specialty serum and plasma products, viral inactivation of animal blood derivatives.

1139 FOTODYNE, INC. Add: 950 Walnut Ridge Dr. Hartland, WI 53029-9388

Technological expertise: PA, TE, T, LP, PMC, P/S, BA, C/TC, H/CF

Tel: (414) 369-7000

Principal products/instrumentation: Human Transferrin and other purified, plasma proteins; HDSS, a human derived, serum-free, IgG-free serum substitute; “A-Gamma” human and animal serum; tissue or cell culture products, including purified proteins, transferring, albumin, human derived serum substitute intended for growing human cells in a completely human environment. Specialty products for use in tissue or cell culture. Protein depleted serum products, i.e., A-gamma fetal bovine serum. Custom prepared tissue/cell culture products.

President/CEO: Richard K.Vitek

Fax: (414) 369-7013 R&D expertise: Development and manufacture of equipment and accessories for molecular biology research and education, including electrophoresis, photodocumentation, TLC, electronic imaging and analysis. Technological expertise: RD, CH/S, PMC

Main products/instrumentation under R&D: Transgenic proteins (preclinical), human and animal derived biologicals, specialty serum, animal blood derivatives.

Principal products/instrumentation: Foto/ Prep I DNA Transilluminator, UV 15,21,26 Transilluminators, Foto/Convertible UV/WL Transilluminator (patent applied for), Foto UV 300 Analytical DNA Transilluminator, Foto/ Phoresis UV Transilluminator, MP-4 Photo documentation System, VariQuest 100 White Light Transilluminator, Foto/Analyst™ Systems.

1138 FOSTER WHEELER ENERGY, LTD.

Main products/instrumentation under R&D: Equipment and accessories for molecular biology research.

Add: Shinfield Park Reading, Berkshire RG2 9FW UK Tel: (44) 0118-913-1234

1140 FOUNDATION FOR GENETIC MEDICINE, INC.

Fax: (44) 0118-913-2333 Web site: www.fwc.com President/CEO: J. C. Blythe Subsidiary of Foster Wheeler Corp. R&D expertise: Process plants engineering for the pharmaceuticals and biotechnology industries.

Add: 10900 University Blvd. MSN 4E3 Manassas, VA 20110-2209 Tel: (703) 993-8385 Fax: (703) 993-8401 E-mail: [email protected] Web site: www.geneticmedicine.org

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President/CEO: Leslie A. Platt, J.D.

Fax: (972) 7-684-7982

Research director: Erin D. Williams, J.D.

E-mail: [email protected]

R&D expertise: Research of policy and ethics related to genetic medicine, related products development.

Web site: www.wnic.co.il

Technological expertise: G, BTS, CH/S Principal products/instrumentation: DNA Patent Database, Genomics lexicon. Main products/instrumentation under R&D: Genetic medicine, gene therapy, genetically engineered antibody.

1141 FOXBORO CO. Add: 33 Commercial St. B51-2D Foxboro, MA 02035 Tel: (508) 698-9400; (888) 369-2676

President/CEO: Shimon Katorza Research director: Doron Alush Subsidiary of Western Negev Initiative Center R&D expertise: Development and production of insect-eating fungi. Technological expertise: BA, AF Main products/instrumentation under R&D: Agriculture, Spodotrol, a biological insecticide, preclinical, insect-eating fungi, insect spray, insect repellent cream.

1143 FRISTAM PUMPS, INC.

Fax: (508) 549-4433

Add: 2410 Parview Rd. Middleton, WI 53562

E-mail: [email protected]

Tel: (608) 831-5001

Web site: www.foxboro.com

Fax: (608) 831-8467

President/CEO: Bruce Robinson

E-mail: [email protected]

Subsidiary of Siebe Intelligent Automation

Web site: www.fristampumps.com

R&D expertise: Research and products development of automation and controls.

President/CEO: Wolfgang Stamp

Joint ventures: Wonderware, APV, Eurotherm, Gestra, Schmidt.

R&D expertise: Design and manufacture of medical sanitary equipment.

Technological expertise: AU, PMC

Technological expertise: BME

Principal products/instrumentation: Biosensors, contract manufacturing products, contract clinical trial products, toxic waste management equipment, Intelligent Automation equipment.

Principal products/instrumentation: WFI series centrifugal pump; Genta series positive displacement pump; F2X self-priming centrifugal pump.

Main products/instrumentation under R&D: Intelligent surveying automatic tablet-filling and counting machine.

Main products/instrumentation under R&D: Medical sanitary equipment.

Subsidiary of Fristam Holding

1144 FSM ECHNOLOGIES, LTD. 1142 FRIENDLY FUNGI, LTD. Add: P.O. Box 321 Neve Dekalim 79779 Israel

Add: 6 Dunrobin Ct. Clydebank Business Park Clydebank, Scotland G81 2NT UK

Tel: (972) 7-684-6079

Tel: (44) 141-951-2112

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Fax: (44) 141-951-1221 President/CEO: Robert G. Hood Research director: M. Roberts R&D expertise: Support of technology through licenses and joint ventures with strategic partners. related products development/manufacture.

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recirculating coolers, Flexi-Goal™ immersion coolers. Main products/instrumentation under R&D: Novel freeze dryers and chillers.

1146 FUGENT LLC

R&D collaboration: Laboratory of Government Chemist (UK); FAS Medical Limited (UK); Scotlab Limited (UK); GEM Biomedical, Inc. (USA).

Add: 1902 Tennyson Ln. Madison, WI 53704

Technological expertise: P/S

Fax: (608) 241-7775

Principal products/instrumentation: Glowgrub™ rapid diagnostic devices; Fibrewell molecular separation systems.

E-mail: [email protected]

Main products/instrumentation under R&D: Teardrop™ high purity rapid DNA (from whole blood) separations systems, DNA purification systems, DNA sequencing systems. Sealed and granted patents: PCT/GB95/ 01834, PCT/GB95/ 01836, PCT/GB95/02829, and PCT/GB95/02834, PCT/GB95/03031.

1145 FTS/KINETICS Add: 3538 Main St. P.O. Box 158 Stone Ridge, NY 12484

Tel: (608) 241-7558

President/CEO: Vladimir Gurevich R&D expertise: Development and manufacture of biotechnology reagents, gene transfer reagents and delivery systems, Icono disperse polymeric beads, HPLC materials. Technological expertise: AF, AB, C/TC, DD, D-D, GT, P/S, SY Principal products/instrumentation: Contract manufacturing products, reagents, vaccines, Gene transfer reagent kits, wide variety of monodisperse nonporous polymeric beads with different functional groups in the surface. Main products/instrumentation under R&D: Biotechnology research reagents, drug delivery systems.

Tel: (914) 687-0071 Fax: (914) 687-7481 E-mail: [email protected]

1147 FUJI SILYSIA CHEMICAL, S.A.

Web site: www.ftssystems.com President/CEO: T. N. Thompson Jr. Subsidiary of U.S. Filter R&D expertise: Development and manufacture of freeze dryers and chillers. Technological expertise: BME, PMC Principal products/instrumentation: FlexiDry™ freeze dryers, Dura-Dry™freeze dryers, Dura-Stop™ Tray Dryers, Triphilizer™ freeze dryers, Bio-Cool™ controlled rate freezer, MultiCool™ low temperature baths, Maxi-Cool™

Add: International Chromatography Center En Budron E9 Le Mont-sur-Lausanne CH-1052 Switzerland Tel: (41) 21-652-3436 Fax: (41) 21-652-4737 E-mail: [email protected] Web site: www.fuji-silysia.com President/CEO: Seijo Takahashi Subsidiary of Fuji Silysia Chemical Ltd., Nagoya, Japan

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R&D expertise: Development and manufacture of silica gel for liquid chromatography.

preclinical; “Resistogram”: anti-retroviral therapy resistance determination, preclinical.

Technological expertise: P/S, BME Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, Spherical Silica, Super Micro-Beads (SMB); Spherical Silica, MicroBeads (MB); Granular Silica (GS). Subsidiary bodies: Fuji Silysia Chemical Ltd. 505 5th Flr, Higashikan, Daini Toyota Bldg 411-27, Meieki, Nakamuraku, Nagoya, Aichi, Japan 450-0002 Tel: (81) 52-583-0451 Fax: (81) 52-583-0455; Fuji Silysia Chemical Ltd (Sales Office-North America) Park 40 Plaza, Highway 55, Ste 290, Durham, NC 27713 Tel: (919) 484-4158, Fax: (919) 544-5090.

1148 GAIFAR GMBH

1149 GALLARD-SCHLESINGER INDUSTRIES,INC. Add: 777 Zeckendorf Blvd. Garden City, NY 11530 Tel: (516) 229-4000/(800) 645-3044 Fax: (516) 229-4015 E-mail: [email protected] Web site: www.gallard.com President/CEO: Sheldon Silbiger Research director: Henry Medollo Subsidiary of Chemische Fabrik Budenheim R&D expertise: Development and manufacture of biomedical items. Technological expertise: COC, DC

Add: Hermannswerder 15 & 16 Potsdam 14473 Germany

Principal products/instrumentation: Biological buffers, bioproducts.

Tel: (49) 331-298-3812

Main products/instrumentation under R&D: Biosensor, bioselective chromatography, biotech wares.

Fax: (49) 331-298-3849 President/CEO: Dr. H. Repke Research director: Dr. H. Repke R&D expertise: Biomedical product research and technology development (AIDS, Functional genomics, bone marrow). R&D collaboration: U.S. biotech companies, German universities, Harvard Medical School.

1150 GALLUS IMMUNOTECH Add: 6570 1st Line West Garafraxa Fergus, ON NIM 2W4 Canada Tel: (519) 843-2918

Technological expertise: F, RD, C/TC, D-D, HTDS, PG

Fax: (519) 843-2918

Principal products/instrumentation: InstantScreen, Instant Confirm, InfectionScreen (TB and HIV), Early Antigen, “Knowledge Protects” — Family: novel ultra-sensitive rapid diagnostics platform for the detection of antigens and antibodies.

Web site: www.gallusimmunotech.com

Main products/instrumentation under R&D: “Functional Genomics Factory”: artificial bone marrow for leukemia and gene therapy,

Technological expertise: PA, P/S, CW, AB

E-mail: [email protected] President/CEO: Kelsye Coulter, Ph.D. Research director: Kelsye Coulter, Ph.D. R&D expertise: Custom development and manufacture of chicken egg-derived antibodies. Principal products/instrumentation: Contract manufacturing products, IgY purification kit.

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Main products/instrumentation under R&D: Chicken egg-derived antibodies, chicken ovalbumin upstream promoter.

1151 GAMETRICS, LTD.

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Main products/instrumentation under R&D: Kit for ex vivo expansion of hemapoietic stem cells, preclinical; cell and tissue culture, cell therapy, cell bank, cell adhesion molecule. Sealed and granted patents: Methods of controlling proliferation and differentiation of stem and progenitor cells. 6,962,698. U.S.

Add: HC 69, Box 50 Alzada, MT 59311 Tel: (307) 878-4494 Fax: (307) 878-4499 E-mail: [email protected] Web site: www.childselect.com President/CEO: Ronald J. Ericsson, Ph.D.

1153 GAMIDA-SENSE DIAGNOSTICS, LTD. Add: P.O. Box 896, Habosem 3 (Kiryat Hamada Ashdod) Ashdod 77107 Israel

R&D expertise: Research of Animal and human sex selection sperm genetics, products manufacture.

Tel: (972) 8-852-1415

Technological expertise: G, P/S

President/CEO: Daniel Kropf

Principal products/instrumentation: 22 + X/Y™ disposable human sperm isolation kit, Epibloc rodenticide (toxicant-sterilant), sperm separation materials.

Research director: Sara Alajem

Main products/instrumentation under R&D: Human sex selection, sperm genetics.

Fax: (972) 8-852-5162 E-mail: [email protected]

R&D expertise: Development, design and production of improved diagnostics using novel rapid test technology, automatic equipment and nucleic acid amplification methods. R&D collaboration: DiaMed AG (Switzerland).

1152 GAMIDA-CELL, LTD.

Technological expertise: PA, RD, P/S, PMC, GA, P/S

E-mail: [email protected]

Main products/instrumentation under R&D: CELLA HPV1 and 2 rapid test, preclinical; CELLA HBsAg rapid test, preclinical; CELLA HCV rapid test, preclinical; nucleic acid amplification methods, automatic analyzer, automatic synthesizer.

CEO: Avi Treves, Ph.D.

Sealed and granted patents: U.S. 5,807,751.

Add: Kanfey Neshari 24 Jerusalem 95464 Israel Tel: (972) 2-654-1702 Fax: (972) 2-651-4998

Research director: Menashe Y. Levy, Ph.D. R&D expertise: Cell and tissue culture, cell therapy.

1154 GAMMA-A TECHNOLOGIES, INC.

R&D collaboration: Hadassah Medical Center.

Add: 520 Huntmar Park Dr. Herndon, VA 20170

Technological expertise: C/TC Principal products/instrumentation: Biologicals, vaccines.

Tel: (703) 318-1027 Fax: (703) 318-9799

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E-mail: [email protected]

Fax: (215) 682-9331

Web site: www.gamma-a.com

E-mail: [email protected]

President/CEO: Anthony G. Gristina, M.D.

Web site: www.gamry.com

R&D expertise: Development of biotechnology medicines; tissue engineering, cell/tissue culture, drug discovery; novel products manufacture.

President/CEO: Dr. Greg Martinchek

Technological expertise: TE, D-D, DD, C/TC, AF, TE Main products/instrumentation under R&D: Concluded preclinicals; preparing IND application submission, nonspecific cellular immune stimulation. Sealed and granted patents: U.S. Patent No. 5,292,513 issued March 8, 1994: a method for nonspecific cellular immune stimulation; and patent pending: compositions and methods for the direct concentrated delivery of passive immunity.

R&D expertise: Research and related products manufacture of electrochemical instrumentation for bioelectrochemical applications. Technological expertise: CH/S, BA, C/TC, PMC Principal products/instrumentation: Electrochemical instruments, biomaterials, biosensors, bioelectrochemical devices.

1157 GARGIULO, INC. Add: 15000 Old 41 North Naples, FL 34110 Tel: (941) 597-3131 Fax: (941) 597-8963

1155 GAMMASTER IRELAND, LTD.

President/CEO: Jeffrey Gargiulo Research director: Jim Augustine

Add: Lodge Road Westport, Co. Mayo Ireland

Subsidiary of Calgene, Inc.

Tel: (353) 982-6902

R&D expertise: Genetically modified research, high-quality fresh product; development and manufacture of antibody and recombinant DNA.

Fax: (353) 982-6903 E-mail: [email protected] President/CEO: James O’Doherty R&D expertise: Technology development of contract irradiation sterilization, related products manufacture. Technological expertise: CW, CS Main products/instrumentation under R&D: Biologicals, chemicals, cosmetics, detergents, diagnostics, food processing, natural products, contract irradiation sterilization.

1156 GAMRY INSTRUMENTS

Technological expertise: AB, RD Main products/instrumentation under R&D: Flavr Savr™ tomato, genetically modified cell, high-quality fresh plasma, antibody fusion protein, recombinant DNA.

1158 GB BIOTECHNOLOGY, LTD. Add: 4 Beaconsfield Ct. Sketty Swansea, W. Glam SA2 9JU UK Tel: (44) 079-220-8190

Add: 734 Louis Dr. Warminster, PA 18974

Fax: (44) 079-229-7402

Tel: (215) 682-9330

President: Dr. R. N. Greenshields

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R&D expertise: Contract item R&D; fermenter manufacture.

Tel: (734) 665-0651

R&D collaboration: CPC Int., INC. (U.S.), Addis Ltd. (UK).

E-mail: [email protected]

Key sales market contracts: BTG Plc. (U.S.), Fisons Plc. (UK). Technological expertise: F, E, P/S, BA, C/TC Principal products/instrumentation: R&D fermenter (ALF) industrial and schools. Main products/instrumentation under R&D: New foods, fermenter controller, fermenter agitation devices.

1159 GDS TECHNOLOGY, INC. Add: 25235 Leer Dr. Elkhart, IN 46514 Tel: (219) 264-7384 Fax: (219) 262-0109 E-mail: [email protected] Web site: www.gdstech.com President: Mark Priebe Research director: Richard Tybach, Ph.D. R&D expertise: Bioprocess engineering products, enzymes for diagnostics and reagents, contract fermentation and bioprocessing. Major partners: Canji, Epicentre, BioNebraska, Pepe International.

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Fax: (734) 913-6495 Web site: www.argus-inc.com/Gelman/Gelman. html President/CEO: Kim A. Davis Research director: Vikas Padhye R&D expertise: Bioprocess engineering products; innovative microfiltration and membrane separation technology. Technological expertise: F, C/TC, LP, P/S, OC, ET, PIS Principal products/instrumentation: Biologicals, enzymes, vaccines, specially chemicals, SuporFlow Cartridge Filters, Super DCF™ Filter Capsules, NanoSpin™ Plus and ZSpin™ Plus Centrifuge Filters, SpiralCap™ Capsule, Acrodisc Syringe Filter, SuporCap™ Capsule Filter. Main products/instrumentation under R&D: 32 mm syringe filter, Phase II; Centrifuge filters, Phase II; Microfiltration apparatus. Subsidiary bodies: Manufacturing: Ann Arbor, MI, USA; Pleasanton, CA, USA; Pensacola, FL, USA; Subsidiaries: Australia; Canada; France; Germany; Ireland; Italy, Japan; UK. Sealed and granted patents: Supor polyethersulfane membrane.

Technological expertise: E, F, LP, BA, P/S Principal products/instrumentation: Agriculture, biologicals, biomass, biosensors, contract manufacturing products, diagnostics, single-cell proteins. Main products/instrumentation under R&D: Diagnostic enzymes, diagnostic reagents, fermented dairy product, fermicidin.

1161 GELTEX PHARMACEUTICALS, INC. Add: 9 4th Ave. Waltham, MA 02154 Tel: (781) 290-5888 Fax: (781) 290-5890 President/CEO: Mark Skaletsky

1160 GELMAN SCIENCES Add: 600 South Wagner Rd. Ann Arbor, MI 48103

Research director: W. Harry Mandeville, Ph.D. R&D expertise: Development and manufacture of polymer-based pharmaceutical products.

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Technological expertise: POS, SY

E-mail: [email protected]

Key license and trade contracts: Chugai Pharmaceutical, Co., Ltd.

President/CEO: Dean Tsao, Ph.D.

Main products/instrumentation under R&D: CholesaGef, bile acid sequestrant, Phase IIIb; ReneGel, phosphate binder, Phase III/IV; polymerized human serum albumin (PHSA), polymeric immunoglobulin receptor.

R&D expertise: Development of PCR reagents and detection method; Custom DNA and peptide synthesis research, related products manufacture.

1162 GEM BIOMEDICAL, INC. Add: 1320 Freeport Blvd. Unit 111 Sparks, NV 89431 Tel: (775) 331-1366 Fax: (775) 331-1716

Research director: Shyh-Chen Ju, Ph.D.

Technological expertise: F, AF, RD, D/S, GA, P/S Principal products/instrumentation: PCR primers, probes, biotinylated probes, control DNA. Sealed and granted patents: Polynucleotide pools enriched in either high-abundance or low-abundance sequences.

President/CEO: George Mismas Research director: Dr. T. L. Keying

1164 GEMINI HEALTH TECHNOLOGIES, INC.

R&D expertise: Development of bioluminescence and chemiluminescence-based assays, instrumentation and systems, related products manufacture.

Add: 12085 Research Dr. #126 Alachua, FL 32615-6832

Technological expertise: BA, SY

Tel: (904) 462-2249

Principal products/instrumentation: Optoeomp series of luminometers, BG™ series of luminometers, GEM Bacterial Systems Total Hygiene Swab Assay.

Fax: (904) 462-2283

Main products/instrumentation under R&D: HIV-1 test using urine as sample (near release), other STD tests using urine as sample source, bioluminescence assay, chemiluminescence assay, bioluminescent probe, chemiluminescent indicator.

President/CEO: Arup Sen, Ph.D.

1163 GEMEMED BIOTECHNOLOGIES, INC. Add: 458 Carlton Ct., Suite B. San Francisco, CA 94080 Tel: (415) 952-8193 Fax: (415) 952-9540

E-mail: [email protected] Web site: www.geminibio.com Research director: Arup Sen, Ph.D. Subsidiary of Electropharmacology, Inc. R&D expertise: Drug discovery and small molecule drug discovery and delivery. Custom synthesis of oligonucleotides and peptides; biotechnology, research and development of novel drug products. R&D collaboration: Elan Pharmaceuticals. Technological expertise: PIS, DD, D-D, G, DDI Principal products/instrumentation: Human genome project, pharmaceuticals, custom manufacturing products.

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Main products/instrumentation under R&D: Small molecule nucleoside analogs. Iontophoresis, drug delivery and electromagnetic field-based drug delivery.

Research director: Gerald F. Vovis, Ph.D.

Sealed and granted patents: Small molecule drugs electromagnetic field application, iontophoresis patch, oligonucleotides, peptides and peptide synthesizer.

R&D collaboration: Rex Denton, Ph.D.

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R&D expertise: Research of population genomics and informatics, related products development. Key sales market contracts: Kevin Rakin, M.B.A. Key license and trade contracts: Kevin Rakin, M.B.A.

1165 GEM PHARMACEUTICALS, INC.

Technological expertise: Q, BI, GT, GA, PG, G

Add: 180 Chandalar Place Dr. Pelham, AL 35124

Principal products/instrumentation: Isogenomics™ Database; CIS*1 Operations; Mednostics™ Markers.

Tel: (205) 621-9911 Fax: (205) 621-8395 Web site: www.gempharm.com President/CEO: Frederick J. Dechow, Ph.D. Research director: Richard D. Olson, Ph.D. R&D expertise: Development, manufacture and commercialization of prescription pharmaceuticals for quality of life improvements for cancer and autoimmune diseases. R&D collaboration: Mountain States Medical Research Institute (MSMRI). Technological expertise: T, CB, SMC, SY, DD, PP, AT Main products/instrumentation under R&D: GPX-100 doxorubicin analog for treatment of breast cancer and pediatric leukemia, clinical; GPX-150 doxorubicin analog for treatment of autoimmune diseases and cancer, preclinical.

Main products/instrumentation under R&D: Clinical genomics programs in asthma and cardiovascular disease and bioinformatics; population genomics marker, population genomics library. Sealed and granted patents: CAS Technology, U.S. Patent 5,427,911; Clasper System, U.S. Patent 5,866,404; Genome Anthologies, U.S. Patent 5,972,614; Haplotypes of the AGTR 1 gene. 6,521,747. U.S.

1167 GENARGEN SRL Add: Pringles 10 2P Buenos Aires 1183 Argentina Tel: (541) 981-1538/4792/0115 Fax: (541) 642-9523 E-mail: [email protected]

1166 GENAISSANCE PHARMACEUTICALS, INC. Add: 5 Science Park New Haven, CT 06511 Tel: (203) 773-1450 Fax: (203) 562-9377 Web site: www.genaissance.com President/CEO: Gualberto Ruano, M.D., Ph.D.

Research director: Jorge Zorzopulos R&D expertise: Product development and manufacture for biotechnology industry; pharmaceutical products representation. Joint ventures: Zelltek and Lab Pablo Cassara for erythropoietin development and eukaryotic cell fermentation. R&D collaboration: Rhein Biotech Marketing agreements with Lab Pablo Cassara for interferon A2b and biomelanin.

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Key license and trade contracts: Biofill S.A.

Tel: (49) 761-203-5498

Technological expertise: F, C/TC, RD, P/S

Fax: (49) 761-203-5499

Principal products/instrumentation: Interferon alfa-2b (INF); Interferon alfa-2a (Avirostat), GMCSF (Growgen ) Interleukin 2 (ILGen).

E-mail: [email protected]

Main products/instrumentation under R&D: Erythropoietin, G-CSF, eukaryotic cell fermentation, biomelanin.

1168 GENBIO Add: 15222 Avenue of Science, Suite A. San Diego, CA 92128 Tel: (858) 592-9300; (800) 288-4368 Fax: (858) 592-9400 E-mail: [email protected] Web site: www.genbio.com President/CEO: Frederick E. Adler Research director: Bryan L. Kiehl, Ph.D. R&D expertise: Research, development, manufacturing and marketing of biotechnology medicines to treat infectious disease and autoimmune diagnostic products in both rapid and batch formats, and other therapeutical drugs.

Web site: www.genovac.de President/CEO: Dr. Wolfgang Zimmermann Research director: Dr. Fritz Grunert R&D expertise: Research and development of cell/tissue culture, polyclonal antibodies and recombinant DNA; related products manufacture. R&D collaboration: GeneScan Europe AG B*R*A*I*NAG. Technological expertise: PA, RD, C/TC, H/CF Principal products/instrumentation: Generation of antibodies by genetic immunization. Main products/instrumentation under R&D: Antibodies against polypeptides, cell/tissue culture, polyclonal antibodies, recombinant DNA. Sealed and granted patents: German patent 19852800, PCT registration PCT/EP99/08678.

1170 GENECARE MEDICAL GENETICS CENTER

Technological expertise: CSDP, GA, GM Key sales market contracts: Sybron. Key license and trade contracts: NIHLYME, Stanford Recombinants, University of California licenses chlamydia. Principal products/instrumentation: Borrelia (Lyme), mycoplasma, Epstein-Barr virus, thyroid autoimmunity, including recombinant TPO and all significant autoimmune markers in rapid format, other new therapeutics and rapid diagnostic kits of infectious disease/ autoimmune disorders.

1169 GENDVAC AG Add: Stefan-Meier-Str. 8 Freiburg D-79104 Germany

Add: P.O. Box 4270 Chapel Hill, NC 275154270 Tel: (919) 942-0021 Fax: (919) 967-9519 E-mail: [email protected] Web site: www.genecare.com President/CEO: Philip Buchanan, Ph.D. R&D expertise: Cytogenetics, research and related products development. Technological expertise: C/TC Main products/instrumentation under R&D: Cytokine, including interleukin, interferon, growth factor, tumor necrosis factor, GM-CSF, etc. Subsidiary bodies: Washington, D.C.

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1171 GENE CHECK, INC.

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1173 GENE CODES CORP.

Add: 1629 Blue Spruce Dr., Suite 106 Ft. Collins, CO 80524

Add: 640 Avis Dr. Ann Arbor, MI 48108

Tel: (970) 472-9951

Fax: (734) 769-7074

Fax: (970) 472-9956

E-mail: [email protected]

E-mail: [email protected]

Web site: www.genecodes.com

President/CEO: Dr. Robert E. Wagner

President/CEO: Howard Cash

Research director: Dr. Robert E. Wagner

R&D expertise: Development, manufacture and marketing of software for bioinformatics.

R&D expertise: Development and manufacture of protein chemistry, chemical synthesis and DNA kits. Technological expertise: GA, RD, P/S, PC, DK Principal products/instrumentation: Mismatch binding proteins (MutS and Homologs), biologicals, diagnostics, mutation detection kits, 96 well mismed binding plates. Main products/instrumentation under R&D: Protein drugs, DNA kits, mismatch repair protein.

Tel: (734) 769-7249

Technological expertise: BI, CH/S Principal products/instrumentation: Human genome project, Sequencher™ software for DNA sequencing, DNA assembly and analysis program, 2007. Main products/instrumentation under R&D: Synthesizer software for DNA synthesis.

1174 GENE COMPANY LIMITED Add: Unit A 8/F Shell Industrial Building 12 Lee Chung St. Chai Wan Hong Kong

1172 GENECO

Tel: (852) 2896-6283 Fax: (852) 2515-9371

Add: St. Margarets Farm South Darenth Dartford Kent DA4 9LB UK Tel: (44) 0132-286-3267 Fax: (44) 0132-286-1200 President/CEO: D. Philip Taylor Research director: D. Philip Taylor R&D expertise: Research customers require plants in a highly specialized environment, plant products development.

E-mail: [email protected] President/CEO: Dr. Cheung Research director: Dr. Andrew Lo R&D expertise: Research and design of lab instruments, reagents and consumables, trading and expertise consultation; development and contract manufacture.

Technological expertise: E, T, CW

Key sales market contracts: Develop rapid text and biochip alliances with www.ebiotrade. com.

Principal products/instrumentation: Contract processing and plant cultivation center, specialist glass houses and transgenic release site.

Technological expertise: E, HTDS, PG, PA, Q, T, RD, R, SY, BI, C/TC, COC, DD, GA, GT, H/CF

Main products/instrumentation under R&D: Plant cell culture, plant cloning vector, plant tissue culture.

Principal products/instrumentation: Organ transplants/culture products, PCR programmable thermal controllers, Automated DNA

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Sequencer, UV Transilluminators, Micromanipulator and Microinjector.

solutions for genomics and proteomics; related novel products manufacture.

Main products/instrumentation under R&D: Laboratory drug information management system, laboratory reagents, labwares.

Technological expertise: BI, CH/S, G

Subsidiary bodies: Sequencing, DNA systems, Microarray Labs.

1175 GENECRAFT Add: Tresckowstr. 10 Munster, NRW 48163 Germany Tel: (49) 25-179-0275 Fax: (49) 25-197-09704 Web site: www.genecraft.de President/CEO: Dr. Dimitrij Plachov R&D expertise: Research of enzymology and enzyme reactor technology, related products manufacture. Technological expertise: E, ERT Principal products/instrumentation: Thermostable DNA polymerases, RNA polymerases, modifying enzymes, restriction enzymes, biochemicals. Main products/instrumentation under R&D: Enzyme reactor technology, enzyme activator, enzymatic polymerization.

1176 GENEDATA AG

Principal products/instrumentation: GeneData WorkBench, GeneData Expressionist, GeneData Phylosopher, GeneData GelTools, Data Impressionist, 2001; ToxPedia Toxicology software, 2007; GeneData Phylosopher, a highly sophisticated system for mining fully sequenced genomes, used for target evaluation and high quality annotation of genomes; GeneData WorkBench, an integrated, web-based package for database searching and sequence analysis; GeneData Expression, a powerful system for the analysis of large and complex gene expression experiments using array technologies; GeneData Impressionist, an advanced system for the large-scale analysis of proteomics data, enables the user to perform a quality control and then to do a highly sophisticated analysis of the data; GeneData CoBi, an Oracle relational database system for storage of sequence, gene expression, and protein expression data with the option to build, customize and integrate additional proprietary databases.

1177 GENE EXPRESSION SYSTEMS, INC. Add: P.O. Box 540170 Waltham, MA 024540170 Tel: (781) 891-8181

Add: P.O. Box 254 Basel CH-4016 Switzerland Tel: (41) 61-697-6099 Fax: (41) 61-697-7244 E-mail: [email protected] Web site: www.genedata.com President/CEO: Dr. Othmar Pfannes Research director: Dr. Othmar Pfannes R&D expertise: R&D of biotechnological scientific softwares, and integrated bioinformatics

Fax: (781) 891-8234 E-mail: [email protected] Web site: www.expressgenes.com President/CEO: Sham Appasani Research director: S. Appasani R&D expertise: Development of reagents for gene expression and analysis, chemicals for life sciences, biotechnology and genomics, related products manufacture.

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Technological expertise: AB, GA, G, CH/S, GE

E-mail: [email protected]

Principal products/instrumentation: Reagents, cDNA characterization primer kit, Gene localization kit using In situ, PCR primer kit for cytokines, DNA Extraction Kits.

President/CEO: Rino Camato, Ph.D.

Main products/instrumentation under R&D: Gene display kits, reagents for gene expression and analysis.

1178 GENE EXPRESS NATIONAL ENTERPRISES, INC. Add: 2130 S. Memorial Pkwy. Huntsville, AL 35801 Tel: (888) 711-8702 Fax: (888) 711-8703 E-mail: [email protected] Web site: www.genexnat.com President/CEO: Bob Zahorchak Research director: Bob Zahorchak

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Web site: www.geneka.com Research director: Pierre Rousseau, Ph.D. R&D expertise: Development and manufacture of bioproducts for transcription factors and functional genomics research. Key sales market contracts: Biomol, Cambridge Bioscience, Bionova, Cientifica, Euromedex, Sanbio, in vitro, Biobase, Broiine, Finnzymes, Funakoshi, Medprobe, BioScientific, Celbio, ChengChin, Transfac. Technological expertise: PA, C/TC, SY, G, GA Principal products/instrumentation: Gel retardation kits, Northern blot kits, antibodies, Norkit Plus, Family kit. Main products/instrumentation under R&D: High throughput screening; Custom research service in gene regulation; DNA microarray, bioproducts for transcription factors, functional genomic marker.

Subsidiary of Gene Express, Inc. R&D expertise: R&D of standardized gene expression analysis, novel products development. Technological expertise: G, GA, GE Principal products/instrumentation: Gene Express System I.

1180 GENELABS DIAGNOSTICS Add: 85 Science Park Dr., #04-01 Singapore Science Park Singapore 118259 Tel: (65) 6775-0008

Main products/instrumentation under R&D: Standardized assays for gene expression analysis; standardized gene expression analyzer.

Fax: (65) 6775-4536

Sealed and granted patents: U.S. 5,639,606; 5,643,765; 5,876,978.

Research director: Theresa Chow

E-mail: [email protected] President/CEO: Noel Ho Subsidiary of Genelabs Technology

1179 GENEKA BIOTECHNOLOGY, INC.

R&D expertise: Development, manufacture and marketing of early detection/diagnostic products.

Add: 5445 Delorimier, Ste. 401 Montreal, Quebec H2H 2S5 Canada

Key license and trade contracts: NTH, Amrad, Chiron.

Tel: (514) 528-9233

Technological expertise: Q, RD, P/S, C/TC, SY, F

Fax: (514) 528-9225

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Principal products/instrumentation: HTLVI/II ELBA, HFV-1 Western blot, HIV-2 Western blot, HTLV-I/II Western blot, Autoblot, dengue blot, RST-hCG, HP/spot, HCV blot, HCV ELISA, HCVSPOT, Helicoblot, CMV Blot, EBV Blot, Autoscan. Main products/instrumentation under R&D: Complete range of rapid tests. Sealed and granted patents: AutoBlot, HEV, HTLV, Helicobacter pylori.

Sealed and granted patents: DNA-binding drugs for gene regulation — U.S., Canada, Australia; Hepatitis E virus vaccine and method, 6,455,492, U.S.; Nucleoside derivatives for treating hepatitis C virus infection, 7,094,768, U.S.; Treatment of subnormal bone mineral density, 6,605,591, U.S.

1182 GENE LOGI, INC. Add: 708 Quince Orchard Rd. Gaithersburg, MD 20878

1181 GENELABS TECHNOLOGIES, INC. Add: 505 Penobscot Dr. Redwood City, CA 94063

Tel: (301) 987-1700 Fax: (301) 987-1701 E-mail: [email protected]

Tel: (650) 369-9500

Web site: www.genelogic.com

Fax: (650) 368-0709

President/CEO: Mark D. Gessler

Web site: www.genelabs.com President/CEO: James A. D. Smith Research director: Ming S. Chen R&D expertise: Drug discovery and development of a new class of pharmaceutical products that selectively regulate gene expression and in the development of GL701, the proprietary hormone treatment for systemic lupus erythematosus (SLE), and the development of drugs based on selective regulation of gene expression. R&D collaboration: SmithKline Beecham — hepatitis E vaccine; Abbott Laboratories — hepatitis E diagnostic; Boehringer Mannheim — hepatitis G diagnostic; Chiron/Ortho — hepatitis G diagnostic. Technological expertise: SMC, AF, D-D, DD, DDI, PG Main products/instrumentation under R&D: GL701 (dehydroepiandrosterone) for lupus, Phase III; GL331 for multiple drug resistant cancers, Phase II; GL438 vaccine for hepatitis E prevention, preclinical; GL701 (dehydroepiandrosterone) for systemic lupus erythematosus (NDA filed).

Research director: Greg Lennon, Ph.D. R&D expertise: Integrated solutions for drug discovery through combination of advanced gene expression and data management technologies into information products for the pharmaceutical industry to reduce the time of drug discovery, development cost, and risk associated with drug discovery and development; related drug products manufacture. Key license and trade contracts: Yale University. Technological expertise: BI, COC, CH/S, GA, G, HTDS, PG, GE Principal products/instrumentation: GeneExpress™ — a suite of three interrelated gene expression databases targeting today’s drug discovery bottlenecks. The three databases, including ①BioExpress™ — target discovery and prioritization through understanding the mechanism of disease; ToxExpress™ — predictive toxicology through understanding the mechanism of action of known toxic compounds; ②PharmaExpress™ — pharmacogenomics through understanding the mechanism of action of known therapeutic compounds;

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③BioRepository™ — a network of clinical centers and academic labs to ensure continual acquisition and expansion of a collection of high-quality and reliable biological samples. All samples in the BioRepository™ have detailed histological and clinical history information, included. READS™ Technology — a patented expression profiling technology for detection of low- to medium-abundant messages. READS, a powerful technology for detecting novel genes associated with disease. DATA ANALYSIS TOOLS — the largest industrial expression profiling database housing array, gel-based and QPCR expression data along with data visualization and analysis tools for data-mining in the context of biology and disease. FLOWTHRU CHIP TECHNOLOGY — a sensitive and flexible three-dimensional chip technology for DNA or protein expression analysis ideal for high throughput screening. Subsidiary bodies: Bioinformatics Data Management Systems Division, 2001 Center St., Ste. 600, Berkeley, CA 94704. Sealed and granted patents: Coding sequence haplotype of the human BRCA1 gene, 6,686,163, U.S.; Computer methods and systems for displaying information relatied to gene expression data, 7,031,843, U.S.

1183 GENEMACHINES Add: 935 Washington St. San Carlos, CA 94070 Tel: (650) 508-1634 Fax: (650) 508-1644

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Principal products/instrumentation: OmniGrid microarrayer, Onini-Grid™; Hydroshear DNA shearing device, HydroShear™; HiGro Oxygenated, incubated shaker, HiGro™; Gel2-Well Colony/Plaque picker, Gel-2-Well™; Revolution Prep Machine™; PolyPlex Oligo Synthesizer, PolyPlex™; Mantis Plaque and Colony Picker, Mantis™. Main products/instrumentation under R&D: TriCycle, GeneSuite. 1184 GENEMEDICINE, INC. Add: 8301 New Trails Dr. The Woodlands, TX 77381 Tel: (281) 364-1150 Fax: (281) 364-0858 E-mail: [email protected] Web site: www.gmed.com President/CEO: Eric Tomlinson, D.Sc., Ph.D. Research director: Norman Hardman, Ph.D. R&D expertise: Research and development of non-viral gene therapy products for human therapy, related therapeutical drugs manufacture. R&D collaboration: Boehringer Mannheim. Key license and trade contracts: Multiple academic (in-license). Technological expertise: GT, DD, G Main products/instrumentation under R&D: IL-2 Gene Medicine (cancer), Phase I; IGF-I Gene Medicine (motor neuropathies), Phase II; non-viral gene delivery therapy drugs. Sealed and granted patents: Numerous nonviral gene delivery and expression patents.

E-mail: [email protected] Web site: www.genemachines.com President/CEO: Scott Hunicke-Smith R&D expertise: Development and manufacture of the state-of-the-art solutions for the automation and instrumentation needs of the genomes community. Technological expertise: Q, R, G, BME, AU, SI

1185 GENENCOR INTERNATIONAL, INC. Add: 4 Cambridge PL 1870S.Winton Rd. Rochester, NY 14618 Tel: (716) 256-5200 Fax: (716) 244-9988

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Web site: www.genencor.corn President/CEO: W. Thomas Mitchell Research director: Michael Arbise R&D expertise: Industrial enzymes and specialty biochemicals development. Technological expertise: E, F, Q, AF, BA, RD, ET, BAT Main products/instrumentation under R&D: Industrial enzymes, specialty biochemicals, EGV I–III; endoglucanase and nucleic acids encoding, non-human carbonyl hydrolase mutants, beta-glucosidase. Subsidiary bodies: R&D Headquarters, Palo Alto, CA., European Headquarters/R&D — Leiden, The Netherlands. Sealed and granted patents: Method for the recombinant production of 1,3-propanediol, 6,953,684, U.S.; EGVI endoglucanase and nucleic acids encoding the same, 7,056,721, U.S.; Proteins producing an altered immunogenic response and methods of making and using the same, 6,897,049, U.S.; EGVII endoglucanase and nucleic acids encoding the same, 7,045,331, U.S.; BGL4 beta-glucosidase and nucleic acids encoding the same, 7,045,332, U.S.; EGVIII endoglucanase and nucleic acids encoding the same, 7,049,125, U.S.; Proteins producing an altered immunogenic response and methods of making and using the same, 6,936,249, U.S.; Directed evolution of microorganisms, 7,125,695, U.S.; BGL5 betaglucosidase and nucleic acids encoding the same, 7,005,289, U.S.; Directed evolution of microorganisms, 6,706,503, U.S.; Enzymes which dehydrate glycerol, 6,803,218, U.S.: Nonhuman carbonyl hydrolase mutants, DNA sequences and vectors encoding same and hosts transformed with said vectors, 6,465,235, U.S.

1186 GENENTECH, INC. Add: 460 Point San Bruno Blvd. S. San Francisco, CA 94080 Tel: (650) 467-4254

Fax: (650) 467-4283 Web site: www.gene.com President/CEO: Arthur D. Levinson, Ph.D. Research director: Dennis Henner R&D expertise: Human biopharmaceuticals and drugs discovery, research, development and production. R&D collaboration: Alkermes, Ariad Pharmaceuticals, Connective Therapeutics, CytoTherapeutics, DePuy, Gene Medicine, GenVec, Hoechst AG, IDEC Pharmaceuticals, Khepri Pharmaceuticals, Roche, Scios Nova, Sensus, Sequana Therapeutics, Tularik, Univax Biologics, Xenova Ltd., Texas Biotechnology Corp. Key license and trade contracts: Advanced Tissue Sciences, Inc. XOMA Corp. Technological expertise: BI, RD, R, CB, C/TC, CC, COC, CH/S, Q, SMC, DD, D-D, PI, PA, P/S, SY, T Principal products/instrumentation: Herceptin® trastuzumab for treatment of HERZ over-expressing metastatic breast cancer; Lucentis to treat AMD, 2006; Ranibizumab (Lucentis), for treatment of patients with neonascular (wet) age-related macular degeneration, 2006; Bevacizucmab (Avastin), for treatment of metastatic carcinoma of the colon and rectum, 2004; Insulin-like growth-factor (IGF-1) to treat thrombopoietin; Protropin® (somatrem for injection), for treatment of human growth hormone deficiency in children; Rituxan® ritiximab for treatment of relapsed or refractory low-grade or follicular CD20-positive B-cell non-Hodgkin’s lymphoma; Nutropin AQ and Nutropin® (somatropin (rDNA origin) for injection) growth hormones, to treat growth failure in children due to chronic renal insufficiency, growth hormone inadequacy in children; Turner’s syndrome; growth hormone inadequacy in adults; Activase® (Alteplase, recombinant), a tissue plasminogen activator, to treat acute myocardial infarction, 1987; acute massive pulmonary embolism; acute myocardial infarction; ischemic stroke within 3 to 5 hours

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of symptom onset, 1996; Pulmozyme® (dornase alfa) Inhalation Solution, to treat cystic fibrosis; management of advanced cystic fibrosis; Actimmune® (Interferon gamma-lb). Main products/instrumentation under R&D: Anti-VEGF Antibody, preclinical; Ras FT Inhibitor, preclinical; Thrombopoietin, preclinical; Oral IIb/IIIa Antagonist, preclinical; 2nd Generation t-PA, Phase I; IGF-1, Phase II; gpl20, Phase II; NGF, Phase II; Anti-IgE antibody, Phase II; Auriculin®. Phase III; Anti-HER2 antibody, Phase III; bevacizumab (Avastin), Phase IV, 2008; tvastuzumab (Herceptin), Phase III, 2008; Omalizumab (Xolair), Phase III, 2008; Herceptin, to treat breast cancer, Phase III–IV; anti-CD11a humanized Mab(hu1124) for moderate to severe psoriasis, Phase III/IV; anti-CD 18 humanized Mab to treat acute myocardial infarction, Phase III; TNKase (second-generation t-PA), to treat acute myocardial infarction, Phase III/IV; Pulmozyme® dornase alfa, Phase II trial in metastatic breast cancer of trastuzumab-DM1, which combines Genentech’s HER2-targeting antibody, 2009; Phase III study of Rituxan (rituximab) plus mycophenolate mefetil (MMF) and corticosteroids in patients with lupus nephritis, 2009. Subsidiary bodies: Manufacturing facility under construction in Vacaville, CA. Sealed and granted patents: Nucleic acids encoding PRO830, 7,109,318, U.S.; PRO274 nucleic acids, 7,122,375. U.S.; Antibody fragmentpolymer conjugates and uses of same, 7,122,636, U.S.; Preparation of human IGF via recombinant DNA technology, RE39,355, U.S.; HIV envelope polynucleotides and immunogenic composition, 7,071,322, U.S.; Method for enhancing proliferation or differentiation of a cell using ob protein, 7,074,397, U.S.; Bv8 nucleic acids and polypeptides with mitogenic activity, 7,060,278, U.S.; Secreted and transmembrane polypeptides and nucleic acids encoding the same, 7,056,736, U.S.; Nucleic acids cncoding PRO189 polypeptides, 7,018,811, U.S.; Crystallization of IGF-1, 7,084,240, U.S.; FVIIa antagonists, 7,084,109, U.S.; Compounds that bind

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HER2, 6,987,088, U.S.; Separate-cisron contructs for secretion of aglycosylated antibodies from prokaryotes, 6,979,556, U.S.; Combination treatment with t-PA variant and low molecular weight heparin, 7,084,118, U.S.; Methods and deoxyribonucleic acid for the preparation of tissue factor protein, 7,084,118, U.S.; Methods and deoxyribonucleic acid for the preparation of tissue factor protein, 6,994,988, U.S.; Methods and deoxyrinucleic acid for the preparation of tissue factor protein, 7,084,251, U.S.; Antibody formulation, 6,991,790, U.S.; PRO1384 nucleic acids, 7,098,003, U.S.; PRO1343 Nucleic acids, 7,029,875, U.S.; Secreted and transmembrane polypeptides and nucleic acids encoding the same, 7,029,874. U.S.; Process for production of polypeptides, 7,029,876, U.S.; Anti-interferonalpha. antibodies, 7,087,726, U.S.; Long-lasting fusion peptide inhibitors of viral infection, 7,090,851, U.S.; Vascular endothelial cell growth factor variants and uses thereof, 7,090,834, U.S.; Humanized anti-ErbB2 antibodies and treatment with anti-ErB2 antibodies, 6,949,245, U.S.; NSP molecules, 6,891,022, U.S.; Protease-deficient cells, 6,921,659, U.S.; Anti-igE antibodies, 6,914,129, U.S.; Hairpon peptides with a novel structural motif and methods relating thereto, 6,914,123, U.S.; Compositions for microencapsulation of antigens for use as vaccines, 6,913,767, U.S.; Secreted and transmembrane polypeptides and nucleic acids encoding the same, 6,913,919, U.S.; Antibody fragment-peg conjugates, 7,005,504, U.S.; Variants of vascular endothelial cell growth factor, 7,005,505, U.S.; Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates, 6,458,355; 6,468,532, U.S.

1187 GENE PROBE TECHNOLOGIES, INC. Add: 8551 Ziggy Ln. Gaithersburg, MD 20877 Tel: (301) 990-8980 Fax: (301) 990-6997

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E-mail: [email protected]

1189 GENESCAPE, INC.

Web site: www.geneprobetech.com President: Bharathi Thyagaraj Research director: Dr. Thyagaraj R&D expertise: Development/manufacture of DNA/RNA products, gene probes.

Add: 3403 American Dr., Suites 1-2 Mississauga, Ontario L4VIT4 Canada Tel: (905) 673-1901 Fax: (905) 673-0367

Technological expertise: Q, AB, GA, GT, P/S, SY

E-mail: [email protected]

Main products/instrumentation under R&D: Biologicals, human genome project, DNA kits, gene probes, DNA probes, DNA/RNA hybrid, DNA replication, DNA transcriptase, DNA repair synthesis.

President/CEO: Anthony S. Johnston

1188 GENERAL LAB & CLEANROOM SUPPLY Add: 810 Lawrence Dr. #128 Newbury Park, GA 91320 Tel: (888) 869-6500 Fax: (805) 376-0901 E-mail: [email protected]

Web site: www.genescapeinc.com Research director: Dr. Lawrence T. Malek R&D expertise: Research of drug target discovery and validation, related products development. R&D collaboration: A “top 30” biotech company (name confidential), University of Toronto, University of Western Ontario. Technological expertise: Q, AB, BI, C/TC, D-D, GA, G, PG, RD Main products/instrumentation under R&D: Drug target, drug transport, subtractive amplification. Sealed and granted patents: Subtractive amplification, U.S. 5,712,127.

President/CEO: Thomas A. Moore Research director: M. Shafkalis R&D expertise: Development and manufacture of chromatography, and lab equipment. Key sales market contracts: Kimble-Kontes, Nalge, Isolyzer, Yamato, Kelvinator, BarnsteadThermolyne, Tedia Chemicals. Technological expertise: F, Q, E, GT, RD, P/S, BA, H/CF, C/TC, SY, DD Principal products/instrumentation: Biological/USP chemicals, filters, cleanroom apparel and wipes glassware, refrigerators/freezers, sterilizers, plasticware. Main products/instrumentation under R&D: Chromatography columns, chromatography media, laboratory drug information management system, laboratory scale purification devices, labwares.

1190 GENESCREEN, INC. Add: 2600 Stemmons Fwy., Ste. 133 Dallas, TX 75207 Tel: (214) 631-8152 Fax: (214) 634-3322 Web site: www.genescreen.com President/CEO: Keith W. Brown Research director: Robert C. Giles R&D expertise: Genetic testing — laboratory R&D services. Technological expertise: Q, R, GA, G, HTDS, PG Main products/instrumentation under R&D: Diagnostics, gene map, gene code, genetic testing, gene probe.

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1191 GENESEARCH PTY, LTD. Add: 14 Technology Dr. Arundel, Queensland 4214 Australia Tel: (61) 7-5594-0299 Fax: (61) 7-5594-0562

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Technological expertise: BI, COC, DD, GA, G, HTDS, PG, RD, R, Q Main products/instrumentation under R&D: Contract research/clinical trial products, DNA kits, DNA damaging diagnostics, drug discovery route.

E-mail: [email protected] Web site: www.genesearch.com.au President/CEO: Dr. J. L. Reichelt

1193 GENESIS MACHINERY PRODUCTS, INC.

Research director: Dr. R. Craig

Add: 400 Eagleview Blvd. Exton, PA 19341

R&D expertise: Research, development and manufacture of recombinant DNA and process scale-up involving bacterial growth and genetics.

Tel: (610) 458-4900

Technological expertise: F, RD, P/S, BA, CH/S Principal products/instrumentation: Contract research/clinical trial products, EcoBac powdered bacteria for waste treatment, Biotox process for treatment of polychlorinated biphenyl wastes; Grease-trap waste treatment process, silage inoculant, Si-Lac Silage inoculant. Main products/instrumentation under R&D: Devices and processes for food waste treatment; biodegradable plastics; biopesticides. Sealed and granted patents: U.S. Patent 4,956,064.

1192 GENESEEK Add: 4701 Innovation Dr. Lincoln, NE 68521 Tel: (402) 472-5133 Fax: (402) 472-4203 E-mail: [email protected] Web site: www.geneseek.com President/CEO: Dr. Abraham Oommen Research director: Dr. Daniel Pomp R&D expertise: Development of genotyping/ DNA sequencing, drug discovery, DNA diagnostics.

Fax: (610) 458-4939 E-mail: [email protected] Web site: www.genmap.com President/CEO: Bruce Smith R&D expertise: Development of capital equipment for pharmaceutical industry, related products manufacture. Principal products/instrumentation: Contract manufacturing pharmaceuticals, West-capper™ vial capping equipment, Phase-Shift™ vial washers, Seal Force Monitor™, capital equipment for pharmaceutical industry.

1194 GENESIS RESEARCH AND DEVELOPMENT CORPORATION LIMITED Add: One Fox Str., Parnell P.O. Box 50 Auckland New Zealand Tel: (64) 09-373-5600 Fax: (64) 09-373 5601 Web site: www.genesis.co.nz President/CEO: Dr. James D. Watson R&D expertise: Research of high throughput DNA sequencing, and functional genomics development of therapeutics with partnerships in forestry, agriculture, horticulture and human health; other biopharmaceuticals research and development.

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Joint ventures: Arbor Gen, LLC — improved forestry trees (www.arborgen.com).

President/CEO: Randal A. Goffe, Ph.D.

R&D collaboration: Corixa Corporation (www. corixa.com), Psoriasis Therapeutic; Immunex Corporation (www.immunex.com); SR Pharma (www.srpharma.com); New Zealand Dairy Board; New Zealand Pastoral Agricultural Research Institute Limited (AgResearch); Horticultural and Food Research Institute of New Zealand Limited (HortResearch).

R&D expertise: Development and manufacture of novel tools for accelerating drug discovery and enhancing plasmid DNA in mammalian cells.

Technological expertise: Q, BI, G, PS, HTDS Main products/instrumentation under R&D: Psoriasis therapeutic, Phase II trials; Asthma therapeutic, preclinical, improved forestry trees, modification methods of gene expression, compositions isolated from plant cells, compounds isolated from M. vaccae. Sealed and granted patents: Psoriasis Therapeutic, Lignin Modification, Preservation of biological material and cells. Polynucleotides, materials, incorporating them, and methods for using them, 6,544,772, U.S.; Compositions and methods for the modification of gene expression, 6,380,459, U.S.; Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use, 6,380,362, U.S.; Compositions isolated from plant cells and their use in the modification, 6,359,198, U.S.; Compounds for treatment of infectious and immune system disorders and methods for their use, 6,358,734, U.S.; Compounds isolated from M. vaccae and their use in modulation of immune responses, 6,361,776, U.S.

1195 GENESPAN CORPORATION

Research director: Ronald W. Berninger, Ph.D.

Technological expertise: TE, C/TC, GT, G, HTDS, R, PG, D/S Principal products/instrumentation: VECTORSMT® Culture media additive for sustaining transient expression in eukaryotic cells; CELLSTASIS® 3-D Culture for in vitro models and tissue engineering; GENEXPANSION™ High throughput screening and purity testing of plasmid DNA, PRISTINEDNA™ plasmid DNA purification. Main products/instrumentation under R&D: Artificial liver for preclinical testing; Artificial model for evaluating aerosolized drug candidates; Solid tumor model for testing anticancer drug candidates; CNS model based upon 3-D culture of dopaminergic neuronal cells, novel tools for accelerating drug discovery and enhancing plasmid DNA in mammalian cells. Sealed and granted patents: U.S. 5,622,857 with foreign counterparts; U.S. 5,532,156; U.S. 5,958, 763; several U.S. patents pending.

1196 GENESYS, LTD. Add: Suite 5, St. Albans House 40 Lynchford Rd. Farnborough, Hants GU14 6EF UK Tel: (44) 0 125-237-6288 Fax: (44) 0 870-164-0382

Add: 19310 North Creek Pkwy., Ste. 100 Bothell, WA 98011-8006 Tel: (425) 482-3003

Web site: www.genesys.demon.co.uk President/CEO: Dr. D. Clark

E-mail: [email protected]

R&D expertise: Development and manufacture of restriction enzymes and DNA modifying enzymes.

Web site: www.genespan.com

Technological expertise: F, Q, GA, P/S

Fax: (425) 482-3005

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Main products/instrumentation under R&D: Biologicals, human genome project, restriction enzymes, DNA modifying enzymes, restriction endonuclease, DNA duplicase, DNA dependent protein kinase, DNA ligase.

1197 GENE TEC CORPORATION Add: 205 Winterberry Ridge Dr. Durham, NC 27713 Tel: (919) 558-9310 Fax: (919) 419-1238 E-mail: [email protected] President:/CEO: Marilyn J. Stapleton, Ph.D.

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President/CEO: Anita I. Busquets Research director: Robert Christy, Ph.D. R&D expertise: Research development and manufacture of reagents, monoclonal and polyclonal antibodies. Joint ventures: Distribute AbCam products in USA. Key license and trade contracts: Baylor University College of Medicine, University of Texas Health Science Center at San Antonio. Technological expertise: PA, C/TC, H/CF, MAE, AB Main products/instrumentation under R&D: Contract manufacturing products, reagents, monoclonal/polyclonal antibodies.

Research director: Marilyn J. Stapleton, Ph.D. R&D expertise: Research and development of in situ and immobilized sample DNA/RNA amplification; products manufacture.

1199 GENE THERAPY SYSTEMS, INC.

R&D collaboration: SBIRS and NIH.

Add: 10190 Telesis Ct. San Diego, CA 92121

Technological expertise: GA, GT, HTDS

Tel: (858) 457-1919

Principal products/instrumentation: Human genome project, Gene Cone™ chambers, EPO.

Fax: (858) 587-1499

Main products/instrumentation under R&D: Gene Flow™ chambers and slide thermocycler; ISA devices, method for immobilized sample amplification.

President/CEO: Anthony Sorge

Sealed and granted patents: U.S. 5,382,511; 5,188,963; 5,281,516; 5,346,672; EPO patent 0502108; others pending on devices and method for Immobilized Sample Amplification.

Web site: www.genetherapysystems.com Research director: Philip Feigner R&D expertise: Research and manufacture of reagents and licensing. Technological expertise: O, RD, GT Main products/instrumentation under R&D: Biologicals, reagents, gene therapy system.

1200 GENETIC DESIGNS, LLC. 1198 GENETEX, INC. Add: 14785 Omicron Dr. San Antonio, TX 78245.

Add: 400 Riverside St., Bldg. 5A Portland, ME 04103 Tel: (207) 797-4461

Tel: (210) 677-8529

Fax: (207) 797-4473

Fax: (210) 677-8843

E-mail: [email protected]

E-mail: [email protected]

Web site: www.geneticdesigns.corn

Web site: www.genetex.com

President/CEO: Eluemuno R. Blyden, Ph.D.

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Research director: Dr. Vladimir Grabko R&D expertise: Computer-aided genetic engineering contract R&D, related products manufacture. Key sales market contracts: Capricorn Products, Inc. Technological expertise: AB, BI, BA, C/TC, CH/S, D-D, GA, G, P/S, RD, Q

models for Type 2 Diabetes, SHHF rat models for heart failure, ZDF KSHHF hybrid kidney failure models. Main products/instrumentation under R&D: ZDF rat models for obesity.

1202 GENETIC PROFILES CORP.

Principal products/instrumentation: Contract manufacturing products, contract research/clinical trials products, Rabies glycoprotein G (recombinant), bioinformatics services, product development services, Computer-aided Genetic engineering services.

Add: 6122 Nancy Ridge Dr. San Diego, CA 92121

Main products/instrumentation under R&D: C-Reactive Protein (recombinant), R&D; Avian Adenovirus Protein Expression Vectors, R&D; Avian Adenovirus Protein Expression Kits, R&D; Genomic Databases, R&D; Avian reverse transcriptase.

Web site: www.geneticprofiles.com

Sealed and granted patents: Avian Adenovirus Vectors pending.

1201 GENETIC MODELS, INC. Add: P.O. Box 68737 Indianapolis, IN 462680737 Tel: (317) 824-7070

Tel: (619) 623-0840 Fax: (619) 623-0842 E-mail: [email protected] President/CEO: Thomas Gilroy, Ph.D. R&D expertise: Research of genetic testing, human paternity testing, custom molecular biology, related products development/manufacture. Technological expertise: RD, P/S, GA Main products/instrumentation under R&D: Diagnostics, human genome project, organ transplants/culture products, genetic testing, human paternity testing, custom molecular biology reagents.

1203 GENETIC RESEARCH INSTRUMENTATION, LTD.

Fax: (317) 824-7080 Web site: www.geneticmodels.com President/CEO: Joe E. Pesek Research director: Dwight R. Owens R&D expertise: Contract research, development and production of disease models for diabetes, heart failure, obesity and kidney failure. Key license and trade contracts: Indiana University; Ohio State University. Technological expertise: DD, GA, G, HTDS, PG Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial product, Gmi™ ZDF fa/fa rat

Add: Gene House, Queenborough Ln. Rayne Essex CM7 8TF UK Tel: (44) 0137-633-2900 Fax: (44) 0137-634-4724 E-mail: [email protected] Web site: www.gri.co.uk/gri President/CEO: Paul Nicklin R&D expertise: Development and manufacture of retail instrumentation for cellular and molecular biology research. Technological expertise: Q, C/TC, COC, CH/S, GA

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Principal products/instrumentation: Water purification systems, carbon dioxide, incubators, general purpose, laminar flow hoods, media filtration devices, balances, pH meters, thermal cyclers, autoclaves, glassware washers/ dryers, other professional instruments for cellular and molecular biology research.

1204 GENETIC RESOURCES, INC. Add: P.O. Box 229 Philo, IL 61864 Tel: (217) 684-2783 Fax: (217) 684-2784 E-mail: [email protected] President/CEO: Chuck Lay Research director: Chuck Lay R&D expertise: Plant breed contract research, development and manufacture of plant breed novel products. Technological expertise: G, CW Main products/instrumentation under R&D: Plant novel products, novel variety for plant breed, plant cell culture, plant tissue culture, plant growth regulator.

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OMIGA 2.0, MacVector 6.5 (Mac); Wisconsin Package (UNIX) and Seqlab, seqweb (Web, UNIX), SeqStore (UNIX); Data Serve (UNIX), and Link. Wisconsin Package Version 10, with its graphical interface Seqlfb, provides enterprise-wide sequencing analysis tools, from fragment assembly, database searching, and multiple sequence alignment to evolutionary analysis, DNA/RNA secondary structure prediction, PCR primer prediction, protein analysis, and more; SeqWeb Version 1.1 furnishes the breadth of analysis of Wisconsin package with an easy web-based interface; SeqStore Version 2.0 furnishes Oracle data management tools, including a database development kit; automated sequence analysis pipeline manager; EST, nucleotide, protein and patent Oracle databases automatically updated, maintenance-free; Wisconsin package RDB, which furnished a comprehensive set of analysis tools that can read and write to the Oracle databases. Main products/instrumentation under R&D: Wisconsin package V1I and Oracle-based sequence analysis, novel sequence analysis softwares.

1206 GENETICS INSTITUTE, INC. 1205 GENETICS COMPUTER GROUP Add: 575 Science Dr. Madison, WI 53711

Add: 87 Cambridge Park Dr. Cambridge, MA 02140

Tel: (608) 231-5200

Tel: (617) 876-1170

Fax: (608) 231-5202

Fax: (617) 876-0388

E-mail: [email protected]

E-mail: [email protected]

Web site: www.gcg.com

Web site: www.genetics.com

President/CEO: John Devereux, Ph.D.

President/CEO: Gabriel Schmergel

Research director: John Devereux, Ph.D.

Research director: Steven C. Clark, Ph.D.

R&D expertise: Sequence analysis software development and research.

R&D expertise: Biopharmaceuticals development, production and commercialization.

Technological expertise: Q, PG, BI, CH/S, E, ET, P/PS

Joint ventures: GI/Yamanouchi, GIA, WyethAyerst.

Principal products/instrumentation: Wisconsin package for Sequence Analysis V9.1,

Key sales market contracts: Boehringer Mannheim, EPO; Chugai Pharmaceutical,

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EPO; Baxter, AHF; Sandoz, GM-CSF, IL-3, IL-6; Schering Plough and Sandoz, GM-CSF. Technological expertise: Q, RD, P/S, SY, C/TC, PMC, D-D, AB, R, F Principal products/instrumentation: Recromon™ (erythropoietin), Epogin™ (erythropoietin), Recombinate™ (AHF), Leucomax™, COM-CSF, EPO, AHF, Bene FIX™ recombinant human factor IX (clotting factor) for treatment of hemophilia B; Neumega oprelvekin (MAb) for prevention of severe chemotherapyinduced thrombocytopenia. Main products/instrumentation under R&D: EPO, AHF, GM-CSF, IL-3, IL-6, NKSF (IL12), Factor DC, RhBMP-I (growth factor) for bone and tissue repair, Phase III/IV; recombinant human interleukin-11 (rhIL-11) to treat psoriasis, Phase III; Refacto recombinant factor VIII (clotting factor) to treat hemophilia A, application submitted; Neumega oprelvekin (MAb) for cancer treatment support, Phase III; IL-11 for treating mucositis. Subsidiary bodies: Andover, Massachusetts; Tokyo, Japan; Paris, France. Sealed and granted patents: Method and composition for treating prostate cancer, 6,913,744, U.S.; Methods for selectively stimulating proliferation of T cells, 6,887,466, U.S.; Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith, 6,972,125, U.S.; Composition and method for treating inflammatory disorders, 6,939545, U.S.; Highly purified mocarhagin, a cobra venom protease, polynucleotides encoding same and related proteases, and therapeutic uses thereof, 6,881,404, U.S.; Antibodies to human IL-17F and other CTLA –8-related proteins, 6,902,735, U.S.; Methods of treating HIV infected subjects, 6,905,680, U.S.; Human GDP-mannose 4,6-dehydratase, 6,861,055, U.S.; Method of using IL-11 for treating mucositis, 6,887,461, U.S.; Formulations for IL-11, 7,033,992, U.S.; Antibodies to human

IL-13bc and methods of their use in inhibiting IL-13 binding, 7,078,494, U.S.; Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent, 7,011,833, U.S.; Method of using IL-11 for inflammation associated with acute pancreatitis, 6,274,135, U.S.; Method of using IL-11 for treating gingivitis, 6,270,759, U.S.; Formulations for IL11, 6,270,757, U.S.; Production and use of IL-6, 6,348,191, U.S.; Formulations for factor 1X, 6,372,716, U.S.; Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains, 6,664,227, U.S.; Methods for producing factor VIII proteins, 6,683,159, U.S.; ICE/CED-3 like protease designated FMH-1, 6,586,225, U.S.; GL50 nucleic acids and uses thereof, 6,521,749, U.S.; Methods for selectively stimulating proliferation of T cells, 6,534,055, U.S.; Method of using IL-11 for inflammation associated with acute pancreatitis, 6,274,135, U.S.; Fusions of P-selectin ligand protein and polynucleotides encoding same, 6,277,975, U.S.

1207 GENETIC THERAPY, INC. Add: 938 Clopper Rd. Gaithersburg, MD 20878 Tel: (301) 590-2626 Fax: (301) 948-3774 President/CEO: Michael D. Research director: Paul Tolstoshev, Ph.D. R&D expertise: Gene therapy research, novel products development. Technological expertise: G Main products/instrumentation under R&D: Tissue-vectors specific replication, gene therapy of genetic disease. Sealed and granted patents: Tissue-vectors specific replication and gene expression, 6,638,762, U.S.; Vectors for tissue-specific replication, 6,551,587, U.S.

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1208 GENETIC VECTORS, INC. Add: 5201 NW 77th Ave., Suite 100 Miami, FL 33166 Tel: (305) 716-0000 Fax: (305) 716-0001

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Gridder, QPLX Colony Picker and Gridder, Microarrayer, genomic imprinting, genopattern analyzer.

1210 GENETIX PHARMACEUTICALS, INC.

E-mail: gvec.com Web site: www.gvec.com President/CEO: Dr. Mead McCabe, Jr. Research director: Dr. Mead McCabe, Jr. R&D expertise: DNA diagnostics development, related products manufacture.

Add: 840 Memorial Dr. Cambridge, MA 02139 Tel: (617) 491-5601 Fax: (617) 576-2421 E-mail: [email protected]

Key license and trade contracts: University of Miami.

Web site: www.genetixpharm.com

Technological expertise: Q, GA, DK

Research director: Phillipe Leboulch, M.D.

Principal products/instrumentation: EpiDNA™ Picogram Assay.

R&D expertise: Research of gene therapy, angiogenesis promotion/inhibition; products development.

Main products/instrumentation under R&D: DNA diagnostics, DNA diagnostic enzymes, DNA diagnostic reagents.

1209 GENETIX LIMITED Add: 63-69 Somerford Rd. Christchurch, Dorset BH23 3QA UK Tel: (44) 120-248-3900 Fax: (44) 120-248-0289 E-mail: [email protected] Web site: www.genetix.co.uk President/CEO: Mark Reid, M.D. Research director: David Elverd R&D expertise: Genome research; related products development and manufacture. Key sales market contracts: BM Equipment, Tokyo, Japan.

President: Ronald Dorazio, M.D.

R&D collaboration: Cordis Corporation. Key license and trade contracts: Rhone Poulenc Rorer, Abbott, Amgen, Theratechnologies, Cordis. Technological expertise: GT, G, PPAT Main products/instrumentation under R&D: Chemotherapy resistant bone marrow in Phase II/III human clinical trials; Anti-angiogenic gene therapy for cancer and retinal diseases, angiogenic gene therapy for cardiovascular disease in preclinical testing. Sealed and granted patents: Exclusive licenses to issued patents for retroviral vector from Columbia University, gene expression enhancer from MIT, lentiviral vector from Dana-Farber Cancer Institute.

1211 GENE TOOLS, LLC.

Technological expertise: CH/S, HTDS, R, G Principal products/instrumentation: Human genome project: 384 Well Plate, Disposable 384 Pin Replicators, Q Bot-Colony Picker and

Add: P.O. Box 1186 Corvallia, OR 97339 Tel: (541) 753-6330 Fax: (541) 753-6360

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E-mail: [email protected]

1213 GENE-TRAK SYSTEMS

Web site: www.gene-tools.com President: James E. Summerton, Ph.D.

Add: 94 South St. Hopkinton, MA 01748

Research director: Paul A. Morco, Ph.D.

Tel: (800) 338-8725; (508) 435-7400

R&D expertise: R&D of morpholino antisense oligos.

Fax: (508) 435-0025

Key sales market contracts: Japan distributor: Funakoshi Co. Ltd.

R&D expertise: Food diagnostics developments, related products manufacture. Technological expertise: RD, PG

Technological expertise: AB, C/TC, CH/S, DD, PMC, P/S, R, SMC, SY

Principal products/instrumentation: GeneTrak® assays, food processing method.

Principal products/instrumentation: Morpholino antisense oligos, special delivery cytosolic delivery system.

Main products/instrumentation under R&D: Food contamination assays, food composition detector.

Sealed and granted patents: 5,142,047 Uncharged polynucleotide-binding; 5,185,444 Uncharged morpholino-based polymers; Peptide composition and method for delivering substances into the cytosol of cells, 7,084,248, U.S.

1214 GENETRANS, INC./GENETRANS DIAGNOSTICS, LLC Add: Augusta, GA 30809 Tel: (706) 481-7207

1212 GENETRACE SYSTEMS, INC. Add: 1401 Harbor Bay Pkwy. Alameda, CA 94502

Fax: (706) 481-7210 E-mail: [email protected] President/CEO: Antonio Milici, M.D., Ph.D.

Tel: (510) 748-6000

Research director: Dr. Antonio Milici

Fax: (510) 748-6001

Subsidiary of Genetrans, Inc.

E-mail: [email protected]

R&D expertise: Research and development of biotechnology transfer/molecular diagnostics; products manufacture.

Web site: www.genetrace.com President/CEO: Christopher H. Becker Research director: Joseph A. Monforte R&D expertise: Utilization of genetic profiling for drug targeting, development of novel drug. R&D collaboration: Incyte Pharmaceuticals, Inc. and Monsanto.

Joint ventures: St. Joseph Hospital. Technological expertise: Q, SMC, RD, C/TC, GA, GT Main products/instrumentation under R&D: Molecular diagnostics, molecular drug design, technology transfer of gene drugs.

Technological expertise: Q, BI, HTDS, R Principal products/instrumentation: Drug discovery R&D software, genetic profiling for drug targeting. Main products/instrumentation under R&D: Genetic screening, gene transduction technique, computer-aided pharmaceutical analysis.

1215 GENETREE, INC. Add: 4015 Fabian Way Palo Alto, CA 94303 Tel: (650) 858-2626 Fax: (650) 494-3893

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E-mail: [email protected]

Tel: (41) 22-702-9900

Web site: www.genetree.com

Fax: (41) 22-702-9999

President/CEO: Terry Carmichael

E-Mail: [email protected]

R&D expertise: Technology research of paternity testing and genotyping; related products development.

Web site: www.genebio.com

Technological expertise: Q, BI, RD, G Principal products/instrumentation: Human genome project, paternity testing, GeneSwab™, specimen collection kits, genotyping technology. 1216 GENETRONICS, INC. Add: 11199 Sorrento Valley Rd. San Diego, CA 92121-1334 Tel: (619) 597-6006 Fax: (619) 597-0119 E-mail: [email protected] Web site: www.genetronics.com President/CEO: Lois Crandell Research director: Dr. Ken Dev Subsidiary of Genetronics Biomedical, Ltd. R&D expertise: R&D and manufacture of electroporation and gene delivery systems.

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President/CEO: Erik J. Baas Research director: Dr. Amos Bairoch R&D expertise: Research and development of proteomics databases, proteomics tools, tailormade databases, support services and training, related products manufacture. R&D collaboration: Swiss Institute of Bioinformatics (SIB). Key license and trade contracts: Swiss Institute of Bioinformatics (SIB). Technological expertise: BI, CH/S, G Principal products/instrumentation: SwissProt database, Prosite database, Swiss-2D database, Secure ExPASy server, Ex-PASyIntranet, Glyco DB, Melanie, Proteomics/ bioinformatics, consulting and training. Main products/instrumentation under R&D: Tailor-made databases and proteomics tools.

1218 GENEVAC, LTD.

Technological expertise: DD, GT Principal products/instrumentation: Complete line of electroporation equipment.

Add: Farthing Rd. Ipswich IP 1 SAP UK

Main products/instrumentation under R&D: Electroporation technology to treat catastrophic illnesses and other serious conditions, high efficiency transfection.

Fax: (44) 147-346-1176

Sealed and granted patents: Company holds 83 patents; High efficiency transfection based on low electric field strength, long pulse length, 6,800,484, U.S.

President/CEO: Dr. Michael Cole

1217 GENEVA BIOINFORMATICS (GENEBIO) Add: Case Postale 210 Geneva 12 1211 Switzerland

Tel: (44) 147-324-0000 E-mail: [email protected] Web site: www.genevac.com Research director: Duncan Guthrie R&D expertise: Development and manufacture of solvent evaporation equipment for drug discovery. Technological expertise: CC, COC, G, HTDS, P/S, PIS, R Principal products/instrumentation: Human genome project, sample concentrators with pressure control, 2007.

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Main products/instrumentation under R&D: Solvent evaporation equipment for drug discovery.

1219 GENEVUE., INC. Add: 38 Santa Rosa Ave. Sausalito, CA 94965

system, RNAspectra™, PerfectWesterrn™, AP-body™. Main products/instrumentation under R&D: Reagents and kits for differential display. Sealed and granted patents: U.S. 5,262,311; 5,599,672; 5,665,547; 5,554,499; 5,965,409; 5,801,000; Japanese 181-441-0007.

Tel: (415) 339-9134 Fax: (415) 339-9134 E-mail: [email protected] Web site: www.genevue.com

1221 GENICA PHARMACEUTICALS CORP.

President/CEO: Michael Konrad

Add: Four Biotech Park 377 Plantation St. Worcester, MA 01605

R&D expertise: DNA diagnostics, consulting.

Tel: (508) 756-2886

Technological expertise: G, CH/S

Fax: (508) 752-7421

Principal products/instrumentation: DNA diagnostics, human genome project.

President/CEO: Robert Flaherty

Main products/instrumentation under R&D: DNA diagnostic assays, DNA diagnostic enzymes, DNA diagnostic agents.

Research director: Michael Boss, Ph.D. R&D expertise: Research and development of diagnostics/therapeutics for neurological diseases, related products manufacture. Key sales market contracts: SRL/Japan.

E-mail: [email protected]

Key license and trade contracts: Children’s Hospital, Medical Center, Boston; Neurological Institute of Columbia Presbyterian Medical Center; Memorial Sloan-Kettering Cancer Center; Hoffmann-La Roche; The Salk Institute; University of Porto, Portugal; University of California; Baylor College of Medicine; Massachusetts Institute of Technology.

Web site: www.genhunter.com

Technological expertise: Q, E, RD, ABE

President/CEO: Zhen Guo

Principal products/instrumentation: Dystrophin test, MAG/GMI autoantibody test, Yo/ Hu/Ri autoantibody test, DNA deletion test, metabolic myopathy tests, amyloidosis test, sulfatide autoantibody test, Lyme antibody capture test, myasthenia gravis test, Eaton/Lambert test, myotonic dystrophy DNA test, fragile X DNA test, Peroxisomal disorders test, adrenoleukodystrophy test, Refsum disease test, Charcot-Marie tooth test, HNPP test, SCA 1 test, APOE test, mitochontdrial DNA test.

1220 GENHUNTER CORPORATION Add: 624 Grassmere Park Dr. Suite 17 Nashville, TN 37211 Tel: (615) 833-0665; (800) 311-8260 Fax: (615) 832-9461

Research director: Jonathan Meade R&D expertise: Production of reagents and kits for differential display, products manufacture. Technological expertise: Q, BA, C/TC, GA, RD Principal products/instrumentation: Biologicals, reagents, RNAmap™, RNAimage, PCR-TRAF, ReversePrime, MessageClean™, HotPrime™, RNApure™, APTAG™ ligand-receptor interaction detection

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Main products/instrumentation under R&D: DNA detection mapping, novel diagnostics/ therapeutics for neurological diseases, DNA damaging test, DNA distortion detection.

1222 GENISPHERE, INC. Add: 14 Philips Parkway Montvale, NJ 07645 Tel: (877) 888-3DNA; (201) 651-3100 Fax: (877) FAX-3DNA; (201) 651-3116 E-mail: [email protected] Web site: www.genisphere.com

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Research director: G. Gauthier R&D expertise: R&D of molecular diagnostics, related products manufacture. Joint ventures: A member of an association of economic interests of the biotechnology companies, OCTOTECH GEE. R&D collaboration: Research laboratories of Auvergne University, SCRI (UK), INSERM, CNRS teams. Technological expertise: Q, BI, GA, RD Main products/instrumentation under R&D: Molecular diagnostics kits, diagnostic reagent of molecular disease.

Research director: Thor Nilsen Subsidiary of Datascope Corp. R&D expertise: Nucleic acid detection.

1224 GENOME SYSTEMS, INC.

Key sales market contracts: Fisher Scientific (U.S. distributor).

Add: 4633 World Pkwy Circle St. Louis, MO 63134

Technological expertise: BI, BA, GA, P/S, RD, SY, HTDS

Tel: (314) 427-3222

Principal products/instrumentation: Contract manufacturing products, monoclonal/polyclonal antibodies, research/clinical trial products, three DNA probe kits for detection in blots.

Fax: (314) 427-3324 E-mail: [email protected] Web site: www.genomesystems.com President/CEO: David Smoller, Ph.D. Subsidiary of Incyte Pharmaceutical

Main products/instrumentation under R&D: High throughput plate systems for highly sensitive detection of DNA and RNA without PCR; fluorescent probes for use on microarrays.

R&D expertise: Development of genome system library and high throughput screening; novel products manufacture.

Sealed and granted patents: 5,175,270; 5,487,973; 5,484,904.

Principal products/instrumentation: Genome systems library screening, large-insert genomic and cDNA clones in a matter of days; genomic library screening, cDNA libraries and screening, high throughput sequencing, FISH, custom robotic colony picking and spotting, and DNA purification kits; Go Germline™ cells and mouse knockout.

1223 GENOLIFE Add: Biopole Clermont-Limagne Rond point du Biopole, Puy-de-Dome Saint Beauzire, Cedex F-63360 France Tel: (33) 47-364-4343 Fax: (33) 47-363-4344 President/CEO: B. Venuat

Technological expertise: Q, T, R

1225 GENOME THERAPEUTICS CORP. Add: 100 Beaver St. Waltham, MA 02154

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Tel: (617) 893-5007 Fax: (617) 893-8277 E-mail: [email protected] Web site: www.genomecorp.com President/CEO: Robert J. Hennessey Research director: Bernd Seizinger R&D expertise: Research and development of genomics, novel products manufacture. R&D collaboration: Versicor, Creighton University. Key license and trade contracts: ScheringPlough, Astra, Bayer. Technological expertise: Q, RD Principal products/instrumentation: Human genome project, PathoGenome™ microbial database. Main products/instrumentation under R&D: Genetically-based therapeutics and biopharmaceuticals, method for amplifying sequences from unknown DNA, shotgun sequencing/ amplification. Subsidiary bodies: 1365 Main St., Waltham, MA, 02154. Sealed and granted patents: Shotgun sequencing and amplification without cloning, 6,528,288, U.S.; Method for amplifying sequences from unknown DNA, 9,846,626, U.S.

1226 GENOMETRIX Add: 2700 Research Forest Dr. The Woodlands, TX 77381 Tel: (281) 465-5000 Fax: (281) 465-5002 E-mail: [email protected] Web site: www.genometrix.com President/CEO: Robert Ellis Research director: Sean Walsh R&D expertise: Development and manufacture of DNA diagnostics.

Technological expertise: BI, CH/S, GA, GT, HTDS, PG Principal products/instrumentation: Research of clinical trial products, diagnostics, in vitro toxicology testing products, microarrays for genotyping and expression analysis, DNA repository and database, protein analysis, bioinformatics software. Main products/instrumentation under R&D: Gene profiling arrays (development), hybridization on chip, well microarrays, protein analysis services, toxicogenomics services or analysis. Sealed and granted patents: Hybridization on chip; 96 well microarrays, array fabrication.

1227 GENOMIC Add: 23 Rue Hector-Berlioz St. Julien en Genevois 74160 France Tel: (33) 450-43-6765 Fax: (33) 450-43-6870 E-mail: [email protected] Web site: www.genomics-tools.com President/CEO: Michel Gazeau R&D expertise: Development, manufacturing and marketing of automata and software for molecular biology and genomics. Technological expertise: BI, RD, P/S, Q, C/TC, G, CH/S, R Principal products/instrumentation: Human genome project, Seqout system for DNA sequencing, Robo-Mic, Visio-Mic image acquisition and analysis, EPHORIC ultra-thin gel electrophoresis apparatus, SPACE-IC high precision multi-channel dispensing automatic programmable tip-spacing from 3 mm to 19 mm, VarioTips manual multi-channel liquid handling devices with instant adjustable spacing, Grind-IC, automatic multi-grinder. Main products/instrumentation under R&D: Bloto-Mic for automatic processing and reading of high density dot blots, Megaextractor,

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DNA and RNA extraction from large samples, software for molecular biology and genomics research. Sealed and granted patents: # 9,511,996.

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R&D expertise: Research, design, development, manufacture, marketing and sale of genomic and proteomic instrumentation, software and consumables; development services. Technological expertise: BI, CH/S, G, R

R&D expertise: R&D and manufacture of software products that accelerate drug discovery and development in pharmaceutical and biotechnology research.

Principal products/instrumentation: Intelligent quantifier, advanced quantifier, 2-D analyzer, DNA sequence assembly manager and film reader, high density grid analyzer, whole band match analyzer, GelPrint™ image documentation and analysis systems, Visage™ image analysis systems, BioSpace digital autoradiography analysis systems, 1-D, 2-D and high density grid analysis, Flexys robot, GelPrint image documentation and analysis systems, 2-D and 1-D BioChip production and analysis systems, 2-D protein picking and processing, genomic solutions.

R&D collaboration: PE Biosystems (now Applied Biosystems) — LinkMapper.

Main products/instrumentation under R&D: Genomic/proteomic instruments.

Key license and trade contracts: GlaxcoWellcome, AstraZeneca, Parke-Davis — Genomica Discovery Manager.

Subsidiary bodies: Nihon Bio Image, Bio Image UK, Genomic Solutions KK, (Japan).

1228 GENOMICA CORPORATION Add: 1745 38th St. Boulder, CO 80301 Tel: (720) 565-4500 Fax: (720) 565 4056 Web site: www.genomica.com President/CEO: Thomas G. Maar, Ph.D.

Technological expertise: Q, BI, CH/S, G, PG Principal products/instrumentation: Genomica discovery manager, Genomica reference database. Main products/instrumentation under R&D: LinkMapper, genetic analysis software, biotechnology project to accelerate drug discovery and development.

1229 GENOMIC SOLUTIONS, INC. Add: 4355 Varsity Dr. Suite E. Ann Arbor, MI 48108 Tel: (734) 975-4800 Fax: (734) 975-4808

1230 GENOPLEX, INC. Add: 6840 N. Broadway Denver, CO 80260 Tel: (303) 429-5800 Fax: (303) 429-8608 Web site: www.genoplex.com President/CEO: Kenneth J. Collins R&D expertise: Development and manufacture of Alzheimer’s therapeutics. Key license and trade contracts: Licensed technology from the University of Colorado. Main products/instrumentation under R&D: Alzheimer’s disease therapeutics, aging therapeutic drug, Alzhemed (tramiprosate).

E-mail: [email protected] Web site: www.genomicsolutions.com President/CEO: Jeff S. Williams Research director: Andrew Jakimcius

1231 GENO TECHNOLOGY, INC. Add: 3047 Bartold Av. St. Louis, MO 63143

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Tel: (314) 645-2050 Fax: (314) 645-3001 E-mail: [email protected] Web site: www.genotech.com President/CEO: F. Alam Research director: I. Ahmad R&D expertise: Research and development of enzymology, carbohydrate biotechnology, gene amplification and cell/tissue culture, related products manufacture. Technological expertise: CB, C/TC, GA, P/S, G Principal products/instrumentation: Contract manufacturing products, GeneCAPSULE™; DotMETRIC; Uni Lane™; Blot-FastStain™; PowerPrep™; geneEXIT™; GEL-file™; Molecular Grade Water; NUCLEIC dot-METRIC™; FASTsilver™; RAPIDstain™; 5-Minute Reversible Stain™; Non-Interfering Protein Assay™, RNase OUT™; Tube-O-DIALYZER™; PinkCLEAN-UP™; proteomic products, and services; 2D-gels; protein and nucleic acid arrays. Main products/instrumentation under R&D: Carbohydrate-binding protein, cell/tissue culture, gene amplification primer, gene amplifier, enzyme immunoassays. Sealed and granted patents: GeneCAPSULE™; all other products have a patent pending.

1232 GENOTHERAPEUTICS, INC. Add: 850 Ridge Lake Blvd., Suite 250 Memphis, TN 38120

Joint ventures: Baylor College of Medicine, University of Tennessee. R&D collaboration: Baylor College of Medicine, University of Tennessee. Technological expertise: DD, GA, GT, H/CF, P/S, Q, E, PA, C/TC, CH/S, RD Main products/instrumentation under R&D: Therapeutics of prostate cancer. Subsidiary bodies: Laboratory Facility Genotherapeutics, Inc. Research Dept — 151, 1030 Jefferson Av., Memphis, TN 38104, Tel: (901) 523-9700, Fax: (901) 523-9772.

1233 GENOTYPES, INC. Add: 61 Airport Blvd., Suite B. San Francisco, CA 94080 Tel: (650) 871-6484 Fax: (650) 871-6486 E-mail: [email protected] President/CEO: Ronald A. Hitzeman, Ph.D. Research director: Ronald A. Hitzeman, Ph.D. R&D expertise: Contract research and development services to develop andimprove yeast strains for pharmaceutical/industrial product (e.g., heterologous proteins applications). Technological expertise: F, C/TC, RD, PC Main products/instrumentation under R&D: Yeastcidin, improved yeast strains, heterologous proteins.

Tel: (901) 818-2148 Fax: (901) 684-1344

1234 GENOVO, INC.

E-mail: [email protected] Web site: www.genotherapeutics.com President/CEO: Mitchell S. Steiner, M.D. Research director: James A. Allay, Ph.D. R&D expertise: Prostate cancer fundamental research, therapeutical drug development and manufacture.

Add: 512 Elm wood Ave. Elmwood Court Two Sharon Hill, PA 19079 Tel: (610) 522-8500 Fax: (610) 522-8548 E-mail: [email protected] Web site: www.genovo.com

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President/CEO: Eric Aguiar, M.D. Research director: Gary Kurtzman, M.D. R&D expertise: Gene therapy research and therapeutical products development and manufacture. Joint ventures: Biogen, gene therapy; Ariad, gene therapy. R&D collaboration: Centre Hospitaller Universitaire de Nantes.

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Microarray Systems, GenStation 3x6, Microarray System, HalfBD — DNA Sequencing Reagent, GenSize Fluorescent Marker. Main products/instrumentation under R&D: HalfCEQ — CEQ2000 DNA Sequencer, reagent, R&D; Kits and slides — microarraying systems, R&D; DNA sequence analysis/ comparison. Sealed and granted patents: HRP and gestation, submitted.

Key license and trade contracts: University of Pennsylvania. Technological expertise: RD, DD, D-D, GT, C/TC, P/S Main products/instrumentation under R&D: Gene therapy for gliomas, liver metastases cancers, cystic fibrosis, familial hyperchoiesteroiemia, anemia, recombinant adeno-associated virus, viral vectors. Sealed and granted patents: Viral vectors and associated technology; methods for production of a recombinant adeno-associated virus, 6793,926, U.S.

1235 GENPAK, LTD. Add: Sussex Innovation Center Science Park Square Falmer, East Sussex BN1 9SB UK Tel: (44) 127-370-4470 Fax: (44) 127-362-6213 E-mail: [email protected]

1236 GENPHARM INTERNATIONAL Add: 2350 Qume Dr. San Jose, CA 951311807 Tel: (408) 526-1290 Fax: (408) 955-9002 Web site: www.genpharm.com President/CEO: Michael A. Appelbaum Subsidiary of Medarex R&D expertise: Development of human monoclonal antibodies from transgenic mice, products manufacture. Key license and trade contracts: DNX, Biogen. Technological expertise: T, RD, H/CF, C/TC, MAE, AB Main products/instrumentation under R&D: Human monoclonal antibodies from transgenic animal.

Web site: www.genpakdna.com President/CEO: Dr. Julian Burke Research director: Dr. Nish Patel

1237 GEN-PROBE INCORPORATED

R&D expertise: Development of biotechnology — DNA sequencing and related products manufacture.

Add: 10210 Genetic Center Dr. San Diego, CA 92121

Technological expertise: PA, Q, BI, CH/S, GT, G, R, PIS, RD

Fax: (619) 410-8625

Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trials products, GenPak Array 21

Tel: (619) 410-8000 Web site: www.gen-probe.com President/CEO: Henry L. Nordhoff Research director: Graham Lidgard, Ph.D.

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Subsidiary of Chugai Pharmaceutical Co. Ltd. R&D expertise: Development, design, manufacture and commercialization of diagnostic products based on company patented genetic probe technologies. Diagnostic products tests detect a wide range of microorganisms, including those causing sexually transmitted disease, tuberculosis, strep throat, pneumonia, fungal infections, cancers and blood borne pathogens.

and kit; linking reagents for nucleotide probes; compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences.

1238 GENSET Add: 24 Rue Royale Paris 75008 France Tel: (33) 1-55-04-5900

R&D collaboration: BioAnalysis Ltd, Chiron Corporation, bioMerieux S.A.

Fax: (33) 1-55-04-5928

Key sales market contracts: Chiron Corporation, bioMerieux S.A.

President/CEO: Andre Pemet

Key license and trade contracts: BioAnalysis Ltd., Stanford University, Becton Dickinson and Co. Technological expertise: CC, E, PA, Q, BI, C/TC, CH/S, GA, PMC, P/S, RD, SMC, SY Principal products/instrumentation: GENPROBE’s PACE™ system: Direct DNA Probes for chlamydia trachomatis and Neisseria gonorrhoeae; AMPLIFIED™ Direct DNA Probe for chlamydia trachomatis; AMPLIFIED™ Direct DNA Probe for mycobacterium tuberculosis; GEN-PROBE™ AccuProbe System: Culture Identification Probes for identification of mycobacterial fungal, bacterial. Main products/instrumentation under R&D: Assays for infectious diseases, blood borne pathogens and cancers; reagents for nucleotide probes, multiple specific nucleic acid sequences, nucleic acid sequence amplification methods, nucleic acid probes, homogeneous protection assays. Subsidiary bodies: 10180 Willow Court, San Diego, CA 92127. Sealed and granted patents: Methods for detection, identification and quantitation of non-viral organisms; homogeneous protection assay; nucleic acid probes for detection and/or quantitation of non-viral organisms; Nucleic acid sequence amplification method, composition

Web site: www.genxy.com Research director: Daniel Cohen R&D expertise: Research of genomics, pharmacogenomics (CNS-metabolism) and DNA Synthesis (Oligonucleotides division), novel products manufacture. Joint ventures: Surgen, subsidiary Genset Pacific Pty Ltd. (Australia), Genset Singapore Biotechnology (Singapore). R&D collaboration: Abbott, Sanofi-Synthelabs, Pharmacia, Ceres, Corixa. Key license and trade contracts: WyethLederle Vacccines, Whitehead Institute for Biomedical Research. Technological expertise: Q, BI, H/CF, CH/S, GA, PG, R, SY Principal products/instrumentation: Massoligos™, Guaranteed Oligos™, Bulk Oligos™, NetGene™. Main products/instrumentation under R&D: Candidate protein for obesity (FAMOXIN), preclinical research. Subsidiary bodies: GENSET SINGAPORE Biotechnology Pte Ltd., The Alpha Bldg. No. 04-28, Singapore Science Park II, 10 Science Park Rd., Singapore 117684; GENSET Corp., 875 Prospect St., Ste. 206, La Jolla, CA 92037, USA; GENSET KK, Kyoto Research Park, 1 Awatacho Chudoji, Shimogyoku, Kyoto 600, Japan.

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1239 GENSYM CORP. Add: 125 Cambridge Park Dr. Cambridge, MA 02140 Tel: (617) 547-2500 Fax: (617) 547-1962 E-mail: [email protected] Web site: www.gensym.com President/CEO: Robert Moore, Ph.D. Research director: Jim Pepe R&D expertise: Development and manufacture of intelligent software for decision support, diagnosis, monitoring, scheduling and advanced control applications using Fuzzy logic and neural networks in industries, including biotechnology, chemical, environmental, pharmaceutical. R&D collaboration: MIT/ERRC for batch design kits. Key license and trade contracts: 3M, Texaco, Monsanto, DuPont, Chevron, Occidental Petroleum, BP, ABB. Technological expertise: CH/S, PMC Principal products/instrumentation: G2® real-time expert system, G2 diagnostic assistant™ (GDA™), NeurOn-Line™, ReThink™, Fault Expert™. Subsidiary bodies: Atlanta, Boulder, Chicago, Dallas, Dortmund, Genoa, Hong Kong, Houston, London, Los Angeles, Munich, Paris, Philadelphia, Seoul, Sydney, Stockholm, Calgary, Cleveland, DC, Ontario, Pittsburgh, Edinburgh, Leiden, Perth, Singapore, Tunis.

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R&D expertise: Research and development of antisense and triple-strand technologies; early commmercialization strategy: dermatological drugs and, through Genta-Jago, oral controlled release products; biopharmaceuticals. Joint ventures: Jagotec AG. R&D collaboration: Chugai Pharmaceuticals, Jagotec AG, Bristol-Myers Squibb/Apothecon, Johnson & Johnson, Baxter Healthcare Corp., Chugai Pharmaceutical. Key license and trade contracts: Jago Pharma AG, Johns Hopkins University, University of Pennsylvania. Technological expertise: SY, AB, DD Principal products/instrumentation: Dermatological drugs, biopharmaceuticals, oral controlled release drugs. Main products/instrumentation under R&D: Oblimersen sodium (G3139, Genasense), Phase III, 2008; Anticode™ products for cancer; Geornatrix (TR) oral controlled-release drugs; international Phase III study of Genasense (oblimersen sodium) for the treatment of advanced melanoma, 2009. Subsidiary bodies: Manufacturing — San Luis Obispo, CA.

1241 GEN TRAK, INC. Add: 5100 Campus Dr. Plymouth Meeting, PA 19462 Tel: (610) 825-5115 Fax: (610) 941-9498

1240 GENTA INCORPORATED

E-mail: [email protected] President/CEO: Michele L. LeGear

Add: 200 Connell Dr., Berkeley Heights, NJ 07922 Tel: (908) 286-9800 President: Raymond Warrell Jr. E-mail: [email protected] Web site: www.genta.com/genta Research director: Lyle Arnold, Ph.D.

Research director: James Kadushin R&D expertise: Research, development, manufacture and marketing of diagnostic/monitoring tests for transplant of related donor/ recipient genetic disorders. Technological expertise: Q, GA, C/TC, CH/S, SY

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Principal products/instrumentation: HLA tissue typing trays, ABC, DR, B27; frozen cell trays; Genclone™ monoclonal antibodies, and new CQuentials™ DNA typing products. Main products/instrumentation under R&D: Diagnostic/monitoring tests for transplant of related donor/recipient genetic disorders.

1242 GENTRA SYSTEMS, INC. Add: 13355 10th Ave., Ste. 120 Minneapolis, MN 55441-5554 Tel: (763) 543-0678 President/CEO: Ruth M. Shuman R&D expertise: Development and manufacture of products for genetic analysis. Technological expertise: C/TC, GA, CH/S Principal products/instrumentation: Puregene® DNA isolation kits, Purescript™ RNA isolation kits. Main products/instrumentation under R&D: Denaturing proteins, DNA kits for genetic analysis. Sealed and granted patents: Formulations and methods for denaturing proteins, 3,115,719, U.S.

1243 GENTROL Add: 302 Woojun Bldg. 286-9 Seokchondong, Songpaku Seoul 138-190 Korea Tel: (82) 2-420-8974 Fax: (82) 2-420-8936 Web site: www.gentrol.com President/CEO: Hyoung Soon Kin R&D expertise: Technology transfer of biotechnology medicines R&D and production. Technological expertise: E, ET, AB, BI Principal products/instrumentation: Technology transfer of biopharmaceuticals, biotech medicines, cytokines.

1244 GENVEC, INC. Add: 65 W. Watkins Mill Rd. Gaithersburg, MD 20878 Tel: (240) 632-0740 Fax: (240) 632-0735 Web site: www.genvec.com President/CEO: Paul H. Fischer, Ph.D. Research director: C. Richter King, Ph.D. R&D expertise: Research of gene therapy for cardiovascular disease, eye disease, cancer and other diseases; related products development. R&D collaboration: Pfizer (therapeutic angiogenesis for coronary artery disease and peripheral vascular disease); Fuso Pharmaceutical Industries (cancer). Technological expertise: DD, GT, G Main products/instrumentation under R&D: Biobypass® therapeutic angiogenesis (VEGF), gene therapy for treatment of cardiovascular disease, including cardiac artery disease and peripheral vascular disease, either as an adjunct or alternative to existing surgical approaches such as cardiac artery bypass grafts and angioplasty, Phase II; TNFerade™ (TNFa), preclinical; PEDF, preclinical; iNOS, preclinical; VEGF 121 (vascular endothelial growth factor), to treat cardiovascular disorders, Phase III; Phase II trial of a new malaria vaccine candidate that includes five antigens from both blood and liver stages of the parasite, 2007. Sealed and granted patents: Over 325 issued and pending throughout the world. Over 40 issued in the U.S.; Adenoviral capsid containing chimeric protein IX, 6,740,525, U.S.; Alternatively targeted adenovirus, 6,455,314, U.S.; Utilizing intrinsic fluorescence to detect adenovirus, 6,447,995, U.S.; Vectors and methods for gene transfer to cells, 6,465,253, U.S.; Method of preparing a eukaryotic viral vector, 6,573,092, U.S.; Non-adenoviral gene productbased complementing cells for adenoviral vectors, 6,677,156, U.S.; Adenovirus fiber shaft composition and methods of use, patent application No. 20080003236, U.S.

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1245 GEN VUE, INC. Add: 1199 CaminoVallecito Lafayette, CA 94549 Tel: (925) 295-9810 Fax: (925) 295-9809 E-mail: [email protected] Web site: www.genevue.com President/CEO: Michael Konrad Research director: Michael Konrad R&D expertise: DNA diagnostics development, manufacture and consulting. Technological expertise: BI, CH/S, GT, G Main products/instrumentation under R&D: DNA mapping/mutant detector, preclinical. Sealed and granted patents: U.S. 5,789,167 Optical detection of position of oligonudeotides on large DNA molecules.

1246 GENXPRESS SERVICE & VERTRIEB GMBH Add: Golfstrasse 23 Moria Worth 9082 Austria Tel: (43) 42-732-1022/0 Fax: (43) 42-732-1022/10 E-mail: [email protected] President/CEO: Michael Zechner and Elke Kosmannhuber R&D expertise: Development and manufacture of reagents/molecular biology machines. R&D collaboration: Vilber Lourmat, Biosal, Macherey-Nagel, Gentra, Panvera, Seqlab, AppliChem, Genecraft, Biosan, Metabion, Axygen.

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1247 GENZYME Add: Genzyme Corporate Offices 500 Kendall Street Cambridge, MA 02142 Tel: (617) 252-7500; PR (617) 768-6602 Fax: (617) 252-7600 President: Leah Monteiro R&D expertise: Research and development of therapeutic drugs of medical areas, including genetic disease, kidney disease, orthopedics, cardiovascular disease, cancer, immune-mediated disease and transplantation, etc. R&D collaboration: Universities, research institutions and private companies; protein therapies, polymer therapeutics, small molecule therapeutics, biomaterials, cell therapy, gene therapy, diagnostics products and services, pharmaceuticals. Technological expertise: DD, GT, C/TC Principal products/instrumentation: Drug research platforms including protein and antibody therapies, polymers and small molecule therapies, cell and gene therapies, and biomaterials. Main products/instrumentation under R&D: Novel biopharmaceuticals for treatment of genetic disease, renal disease, oncology transplant/immune disease, cardiovascular disease; Phase III study of mipomersen in patients with homozygous familial hypercholesterolemia (hoFH) met its primary endpoint in an intent-to-treat analysis, with a 25% reduction in low-densily lipoprotein cholesterol (LDL-c) after 26 weeks of treatment vs 3% for placebo, which constitutes an average reduction greater than 100 mg/dl., 2009.

Technological expertise: Q, T, AB, C/TC, CH/S, GA, P/S, RD, SY

1248 GENZYME PHARMACEUTICALS

Principal products/instrumentation: Reagents, Thermocyclers, Oligos/Custom Sequencing, Metabion/Seqlab, DNA/RNA Purification kits, Macherey-Nagel.

Add: One Kendall Sq. Cambridge, MA 02139

Main products/instrumentation under R&D: Molecular biology reagents.

E-mail: [email protected]

Tel: (617) 374-7248; (800) 868-8208 Fax: (617) 252-7772 Web site: www.genzyme.com/pharmaceuticals

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President: Mara Aspinall Subsidiary of Genzyme Corporation, General Div. R&D expertise: Genzyme novel pharmaceuticals develops, manufactures and markets active pharmaceutical ingredients and excipients, including pharmaceutical peptides, peptide segments and intermediates, amino acid derivatives, synthetic lipids and medical grade hyaluronic acid. Technological expertise: F, PIS, P/S, SY, PLHDDT Principal products/instrumentation: Thyrogen thyrotropin alpha for injection (recombinant hormone) for detection and treatment of thyroid cancer, 1998; Alglucosidase myozyme, treatment of Pompe disease (GAA deficiency), 2005; Clofarabine (collar), treatment of pediatric patients 1 to 21 years old, 2004; Custom synthesis products of peptides for pharmaceutical applications; specialized amino acid derivatives; peptide segments and intermediates, 2005; Cerezyme imiglucerase for injection (recombinant glucocerebrosidase) for treatment of Gaucher disease; Carticel autologous cultured chondrocytes (cell/tissue therapy) for repair of clinically significant, symptomatic cartilaginous defects of the femoral condyle (medical, lateral or trochlear) caused by acute or repetitive trauma; tumor therapeutics, Phase II/III, 2008. Main products/instrumentation under R&D: Aldurazyme alronidase for injection, enzyme replacement therapy for mucopolysaccharidosis1(MPS-1), Phase III/IV; Alpha-galactosidase for treatment of Fabry disease, Phase III/IV; alphaglucosidase to treat Pompe disease, Phase II; Ex vivo stem cell/retrovirus vector (gene therapy), for treatment of Gaucher disease, Phase II; rh Antithrombin III (recombinant) for control of blood clotting coronary artery bypass surgery, Phase III/IV; NeuroCell-HD (cellular transplantation therapy) to treat Huntington’s disease, Phase II; NeuroCell-PD (cellular transplantation therapy) to treat Parkinson’s disease, Phase III/IV; Transforming growth factor beta-2 (TGFB2) to treat chronic skin ulcers, Phase III.

Subsidiary bodies: Genzyme Pharmaceuticals, Sygena Facility, Eichenweg 1, CH-4410 Liestal, Switzerland (Pharmaceutical GMP manufacturing facility for peptides and lipids); Tel: (41) 61-906-5959, Fax: (41) 61-906- 5958.

1249 GENZYME TRANSGENICS CORPORATION Add: P.O. Box 9322 Framingham, MA 017019322 Tel: (508) 620-9700 Fax: (508) 370-3797 Web site: www.transgenics.com President/CEO: Dr. Sandra Nusinoff Lehrman Research director: Dr. Harry Meade R&D expertise: Development and production of recombinant proteins. Technological expertise: T, P/S, RD Main products/instrumentation under R&D: Contract manufacturing products, rh Antithrombin III (recombinant) for control of blood clotting during coronary/artery bypass surgery, Phase III/IV and other proteins in various stages of development. Subsidiary bodies: 166-acre pharmaceutical dairy farm in MA; Argus Research Laboratories, Horsham, PA; BioDevelopment Laboratories, Cambridge, MA; Mason Laboratories, Worcester, MA; Redfield Laboratories, Redfield, AR; Washington Laboratories, Rockville, MD.

1250 GEO-MICROBIAL TECHNOLOGIES, INC. Add: East Main St. P.O. Box 132 Ochelata, OK 74051 Tel: (918) 535-2281 Fax: (918) 535-2564 E-mail: [email protected] President/CEO: Daniel C. Hitzman

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Research director: Donald O. Hitzman, Ph.D. R&D expertise: Research of petroleum and environmental microbiology, related products manufacture. Joint ventures: The LATA Group. R&D collaboration: BJ Services. Key sales market contracts: Phillips Petroleum Co., Microbial Oil Survey Technique (MOST). Key license and trade contracts: Phillips Petroleum Co. Technological expertise: F, BA Principal products/instrumentation: Bioremediation, specialty growth media for SRBs and custom media; balch black butyl rubber stoppers. Main products/instrumentation under R&D: In-situ bioremediation technologies. Sealed and granted patents: U.S. Patents 5,044,435; 5,750,392. 1251 GEORGE FISCHER, INC. Add: 2882 Dow Ave. Tustin, CA 92780-7285 Tel: (714) 731-8800 Fax: (714) 731-6201 E-mail: [email protected] Web site: www.us.piping.georgefischer.com President/CEO: Chris Blurner R&D expertise: Development and manufacture of piping systems for pharmaceutical industry, particularly high purity applications. Technological expertise: BME Principal products/instrumentation: BCF bead and crevice free and IR (infrared welding), PVDF (polyvinylidene fluoride) piping systems, polypropylene (natural and pigmented) piping systems. 1252 GEORG FISCHER ANDERSON GMBH Add: Hesslingsweg 71 Dortmund D-44309 Germany

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Tel: (49) 23-19-2560 Fax: (49) 23-1-925-6150 E-mail: [email protected] President/CEO: Friedhelm Hellnan Research director: Klaus Schnell Subsidiary of George Fischer Beteilingungs GMBH R&D expertise: Development and manufacture of valves for biotechnology, pharmaceutical industry, food industry, laboratory and analytical applications, metering pumps. Technological expertise: BA, F, PMC, BME Principal products/instrumentation: Forged diaphragm valves, miniature teflon solenoid valves, miniature solenoid pinch valves, metering pumps, tank washers. Main products/instrumentation under R&D: New diaphragms; miniature solenoid latching (impulse) valves for the complete range; metering pumps.

1253 GEOSPIZA, INC. Add: 2442 NW Market St., Ste. 344 Seattle, WA 98107 Tel: (206) 633-4403 E-mail: [email protected] Web site: www.geospiza.com President/CEO: Todd M. Smith, Ph.D. R&D expertise: Development and manufacture of bioinformatics systems solutions, products and for high throughput analysis; software for biotechnology. Technological expertise: BI, HTDS, BTS Principal products/instrumentation: Finch™ Suite, Finch™ — Chromatogram Server, Finch™ — BLAST Server. Main products/instrumentation under R&D: Bioinformatics systems solutions, biotechnology softwares.

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1254 GERLINDE KISKER PRODUKTE T.D. Add: P.O.B. 2105 Muehlhausen D-69240 Germany Tel: (49) 62-226-4462

applications of nuclear transfer other than modification of milk. Main products/instrumentation under R&D: Pig organs for human transplants, Phase I; contract research/clinical trial products; organ transplants/culture.

Fax: (49) 62-226-4686 E-mail: [email protected] Web site: www.kisker-biotech.com

1256 GERON CORP.

President/CEO: G. Kisker, Dipl.oec.troph.

Add: 230 Constitution Dr. Menlo Park, CA 94025

Research director: G. Kisker, Dipl.oec.troph.

Tel: (650) 473-7765

R&D expertise: Supply of products for biotechnology in Germany and East Europe, address mailing service.

Fax: (650) 473-7701

Technological expertise: C/TC, GA, P/S Principal products/instrumentation: Biologicals, instrumentation, plastics, autoradiography cassettes and intensifying screens, products for PCR, plastic consumables, and laboratory equipment.

1255 GERON BIO-MED, LTD.

E-mail: [email protected] Web site: www.bio.com/companies/geron.html President/CEO: Ronald W. Eastman Research director: Calvin B. Harley, Ph.D. (Chief Scientific Officer) R&D expertise: Discovery, research and development of therapeutic and diagnostic products based on the common biological mechanisms underlying cancer and other agerelated diseases. Technological expertise: G, E

Add: Roslin Biotechnology Centre Roslin, Midlothian, Scotland EH25 9PS UK Tel: (44) 131-527-4272 Fax: (44) 131-527-4474 E-mail: [email protected] President/CEO: Dr. Tom Okarma Research director: Prof. Ian Wilmut Subsidiary of Geron Corporation R&D expertise: Genetic modification research of farm animals via nuclear transfer to develop biomedical products such as organs, blood-products and antibodies.

R&D collaboration: Kyowa Hakko Kogyo Co., Ltd.; Pharmacia & Upjohn. Key license and trade contracts: Oncor, Boehringer Mannheim, Dako, Kyowa Medex, PharMingen. Technological expertise: SMC, C/TC, COC, D-D, HTDS, P/S, R Main products/instrumentation under R&D: Anticancer agents; clinical study of GRNOPC1, a cell therapy for spinal cord ingury, 2008.

1257 GESHER ADVANCED BIOTECS

Technological expertise: BS, G, GA Key license and trade contracts: Roslin Institute — exclusive license for all biomedical

Add: P.O. Box 97 Beit Neqofa 90830 Israel Tel: (972) 2-570-0381

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Fax: (972) 2-570-0586

Web site: www.gilead.com

E-mail: [email protected]

President/CEO: Susan Hubbard

Research director: Avaraham Lavan

Research director: John C. Martin, Ph.D.

R&D expertise: Automation research of recombinant DNA cloning (genetic engineering) combinatorial genetics, related products development. Technological expertise: E, T, GA, GT, HTDS, PIS, RD, PG

R&D expertise: Research and manufacture of small molecule antivirals, cardiovascular therapeutics and code blocker compounds; research/development of other biopharmaceuticals.

Main products/instrumentation under R&D: Recombinant DNA.

R&D collaboration: GlaxoSmithKline, ARPA, American Home/Storz.

1258 GESIM GESELLSCHAFT FUR SILIZIUM-MIKROSYSTEME MBH Add: Bautzner Landstr. 45 GroBerkmannsdorf 01454 Germany Tel: (49) 351-2695-322 Fax: (49) 351-2695-320 E-mail: [email protected] Web site: www.gesim.de. President/CEO: Dr. Steffen Howitz Research director: Dr. Steffen Howitz R&D expertise: Development and manufacture of liquid handling devices and pipetting equipment for the submicroliter range. Technological expertise: R, BME Principal products/instrumentation: Contract manufacturing product, Nanoliter pumps, DNA-Arranger, contract research for the “Lab-on-a-Chip”. Main products/instrumentation under R&D: Liquid handling devices, pipetting equipment for the submicroliter range.

1259 GILEAD SCIENCES, INC. Add: 333 Lakeside Dr. Foster City, CA 94404 Tel: (650) 574-3000 Fax: (650) 578-9264

Technological expertise: Q, P/S, C/TC, SY, D-D, AB Principal products/instrumentation:  Vistide cidofovir injection (nucleotide analogue) to treat cytomegalovirus retinitis AIDS patients; Letairis (ambrisentan), for treatment of pulmonary arterial hypertension, 2007; Efavirenz, to treat patients infected by HIV, 2006; Atripla, to treat patients infected by HIV-1, 2007. Main products/instrumentation under R&D: V1STIDE™ (cidofcvir intravenous) for cytomegalovirus retinitis, Phase II/III; GS 393 for HIV, Phase I/II; GS 840 oral for HIV, Phase I/II; cidofovir topical gel for herpes simplex virus, Phase I/II; cidofovir topical gel for human papillomavirus, Phase I/II, adefovir dipivoxil (nucleotide analogue) for treatment of hepatitis B, Phase III/IV; tenofovir disoproxil fumarate (oral PMPA), nucleotide analogue to treat HIV infection and AIDS, Phase III/IV; Phase II trial of Gs 9137, an HIV integrase inhibitor, 2007; Phase III study of aztreonam lysine for inhalation treatment of people with cystic fibrosis (CF) who have pulmonary pseudomonas aeruginosa, 2009. Sealed and granted patents: High affinity TGF-beta nucleic acid ligands and inhibitors, 6,715,616, U.S.; Methods of producing nucleic acid ligands, 6,716,583, U.S.; Vascular endothelial growth factor nucleic acid ligand complexes, 6,962,784, U.S.; Polypeptides and coagulation therapy, 7,060,484,

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U.S.; Methods and compositions for treatment of tumors using nucleic acid ligands to platelet-derived growth factor, 7,141,375, U.S.; Vascular endothelial growth factor nucleic acid ligand complexes, 6,426,335, U.S.; Method of targeting a specific location in a body using phospholipid and cholesterol liposomes which encapsulate an agent, 6,274,115, U.S.

1260 GILMONT INSTRUMENTS (DIV. OF BARNANT CO.) Add: 28 W 092 Commercial Dr. Harrington, IL 60010 Tel: (800) 637-3739

R&D expertise: Peptide research and development, and peptide analytical instrumentation manufacture. Technological expertise: P/S, R, COC, HTDS, CS Principal products/instrumentation: Liquid chromatography systems and automated liquid handling/sample preparation instruments; prepELS™ II detector, as the primary, or as an additional detector to any Gilson preparative or analytical system or to any other HPLC system, 2007. Main products/instrumentation under R&D: AMS 422 and peptide purification system, novel peptide analytical instruments, peptide hormone, peptidoglycan.

Fax: (847) 381-7053 E-mail: [email protected] Web site: www.barnant.corn

1262 GL APPLIED RESEARCH, INC.

President/CEO: George Sezemsky

Add: 142 HawleySt P.O.Box 187 Graysiake, IL 60030

Subsidiary of Barnant Co.

Tel: (847) 223-2220

R&D expertise: Development and manufacture of flow meters, viscometers, and other laboratory instrumentation.

Fax: (847) 223-2287

Technological expertise: BME, SI, HC

President/CEO: Edgar Watson, Jr.

Principal products/instrumentation: Gilmont flow meters, viscometers, laboratory instruments.

Research director: Edgar Watson, Jr.

Main products/instrumentation under R&D: Laboratory professional instruments for pharmaceutical research, labwares.

1261 GILSON, INC. Add: 3000 West Beltline Highway P.O. Box 620027 Middleton, WI 53562-0027

E-mail: [email protected]

R&D expertise: Biomedical instrument development and manufacturing. Technological expertise: PMC, GA Principal products/instrumentation: Instruments, contract manufacturing products, GTC-2 Genetic Thermal Cycler; LTM-2 Low Temperature Module, Process Photometer. Main products/instrumentation under R&D: High-performance liquid chromatography, high performance ultrafilter.

Tel: (608) 836-1551 Fax: (608) 831-4451 Web site: www.gilson.com President/CEO: Dr. Robert E. Gilson Research director: David Baird

1263 GLAS-COL Add: 711 Hulman St. P.O. Box2128 Terre Haute, IN 47802-0128

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Tel: (812) 235-6167 Fax: (812) 234-6975 E-mail: [email protected] Web site: www.glascol.com President/CEO: Raymond E. Rickert Research director: Steve Sterrett R&D expertise: Development and manufacture of heating and mixing equipment for science and industry. Technological expertise: BME Principal products/instrumentation: Heating mantles, shakers, stirrers. Main products/instrumentation under R&D: Heating cabinet, mixing agitator.

393

comminution, Gy-Ro® Mill comminution of hard materials, sample dividers and splitters; peristaltic pumps; coolers; grinding beads/ media of glass, steel, and ceramics. Main products/instrumentation under R&D: Dyno-Mill® cell disruptor, advanced modifications for higher efficiency and cooling, blanders, comminution equipment, novel comminution equipment.

1265 GLEN RESEARCH CORP. Add: 22825 Davis Dr. Sterling, VA 20164 Tel: (703) 437-6191 Fax: (703) 435-9774 E-mail: [email protected]

1264 GLEN MILLS, INC.

Web site: www.glenres.com President/CEO: Hugh Mackie, Ph.D.

Add: 395 Allvood Rd. Clifton, NJ 07012

Research director: Hugh Mackie, Ph.D.

Tel: (973) 777-0777 Fax: (973) 777-0070

R&D expertise: DNA research and products manufacture.

E-mail: [email protected]

Technological expertise: SY

Web site: www.glenmills.com

Principal products/instrumentation: Chemicals for DNA research.

President/CEO: P. Kendall Research director: S. Goldberg R&D expertise: Development, manufacture and marketing of laboratory, pilot plant, and production equipment for cell disruption, blending, size reduction, and sampling equipment. Major partners: W. A. Bachofen A.G. (Swiss) Joint ventures: Glen Creston Ltd., comminution equipment. Key sales market contracts: WA Bachofen, AG, cell disrupters, blenders. Technological expertise: P/S, BA, BME, C/TC Principal products/instrumentation: Polytron® Homogenizer, Megatron®’ Homogenizer; Dyno®-Mill cell disruption, Turbula® ShakerMixer blender, Micro Hammer Cutter Mill

Main products/instrumentation under R&D: DNase reagents, DNA cloning vectors, DNA coated gold microparticle, DNA detection kits, DNA extractor.

1266 GLIATECH, INC. Add: 23420 Commerce Park Rd. Cleveland, OH 44122 Tel: (216) 831-3200 Fax: (216) 831-4220 President/CEO: Thomas O. Oesterling, Ph.D. Research director: Kurt Bninden, Ph.D. R&D expertise: Research of surgical adhesion prevention; cognition modulation; Alzheimer’s disease — therapeutic technology based on

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unique properties of glial cells, related products development.

Tel: (416) 443-2209

Key license and trade contracts: Case Western Reserve University, Baylor University, University of Toledo, Brown University, University of Miami.

E-mail: [email protected]

Technological expertise: F, Q, E, D-D, P/S, H/CF, C/TC, SY

R&D expertise: Contract developing and manufacturing of biopharmaceutical products.

Main products/instrumentation under R&D: ADCON®-L and ADCON®-TN, ADCON-L and ADCON-T/N, Phase III/IV; Alzheimer’s disease therapeutic technology.

Technological expertise: CW, CS

1267 GLOBAL BIOTECHNOLOGY Add: Innovation Park 1673 W. Paul Dirac Dr. Tallahassee, R 32310 Tel: (850) 374-4430 Fax: (850) 575-8319

Fax: (416) 443-2200 Web site: www.globalpharminc.com President/CEO: Myron Junyk

Principal products/instrumentation: Contract manufacturing products. Main products/instrumentation under R&D: Biotherapeutics, biotin enzymes, biochip, biologicals.

1269 GLOBEPHARM, LTD. Add: P.O. Box 89C Esher, Surrey KT10 9ND UK

President/CEO: Lloyd Wolfinbarger, Jr., Ph.D.

Tel: (0372) 465-307

Research director: A. Gib DeBusk, Ph.D.

President/CEO: Dr. J. Bleby

R&D expertise: Development of marine biotechnology medicines sources, marine collagens manufacture.

Research director: Dr. H. Donnelly

Joint ventures: BioScience Consultants. R&D collaboration: Marine Collagen Corp. Key license and trade contracts: BioScience Consultants. Technological expertise: TE, BA, C/TC, MP Principal products/instrumentation: Marine collagens. Main products/instrumentation under R&D: Marine biotech medicines, marine lipid concentrate.

Fax: (0372) 468-818

R&D expertise: Research and development of biomedical products. Technological expertise: C/TC Principal products/instrumentation: Animal sera for cell culture, biologicals. Main products/instrumentation under R&D: Specialist cell culture media, DNA probes for diagnosis of laboratory animal diseases.

1270 GLOBE SCIENTIFIC, INC. Add: 610 Winters Ave. Paramus, NT 07652

1268 GLOBAL PHARM, INC. Add: 865 York Hills Rd. Toronto, Ontario M3B 1Y5 Canada

Tel: (201) 599-1400 Fax: (201) 599-1406 E-mail: [email protected] Web site: www.globescientific.com

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President/CEO: Milton Diamond R&D expertise: Development and manufacture of laboratory plasticware. Technological expertise: CH/S Principal products/instrumentation: Extensive line of generic plastic. Main products/instrumentation under R&D: Laboratory plasticwares, labwares, biotech wares.

1271 GLYCOBIOTICS Add: 183 Paradise Blvd. Suite 103 Athens, GA 30607 Tel: (706) 208-0480 Fax: (706) 208-0480 E-mail: [email protected] Web site: www.glycobiotics.com President/CEO: Dr. Ole Hindsgaul Research director: Dr. M. Shoreibah R&D expertise: Research of drug discovery, drug design, and drug delivery, related products development.

395

R&D expertise: Research of cancer, infectious diseases, chronic inflammation and cardiovascular diseases, related prevention and therapeutical drugs manufacture. R&D collaboration: Mount Sinai (Toronto) research agreement on TGF antagonists; National Research Council (Canada) on antibacterials research; Protein Engineering Network of Centres of Excellence on structurebased design; Princess Margaret Hospital and the University of Toronto to generate novel and bacterial agents. Technological expertise: BI, CB, C/TC, COC, CM/S, DD, D-D, G, HTDS Main products/instrumentation under R&D: GD0039 for treatment of solid tumor, Canada, Phase II; GD0039 for chemoprotection, U.S., Phase I/II; V21 for treatment of cardiovascular disease, preclinical; V20 for treatment of cardiovascular disease, preclinical. Sealed and granted patents: Over 30 patents issued or pending for its technologies.

1273 GLYCOSYNTH

R&D collaboration: Schering-Plough. Technological expertise: CB, C/TC, COC/CH/S, D-D, DD, E, F, H/CF, CC

Add: 14 Craven Ct. Winwick Quay Warrington, Cheshire WA2 8QU UK

Main products/instrumentation under R&D: Contract development products, drug discovery route, drug delivery platform.

Tel: (44) 192-557-5075 Fax: (44) 192-557-5121 E-mail: [email protected] Web site: www.glycosynth.co.uk

1272 GLYCODESIGN, INC. Add: 480 University Ave., Suite 900 Toronto, ON M5G 1V2 Canada Tel: (416) 593-6027 Fax: (416) 593-8988 E-mail: [email protected] Web site: www.glycodesign.com President/CEO: Dr. Jeremy Carver

President/CEO: Dr. Mike Burton R&D expertise: Manufacture of enzyme substrates. Technological expertise: SY Principal products/instrumentation: X-gel; X-glucuronide; M.U.G., Indoxyl-glucuronide. Main products/instrumentation under R&D: Enzyme substrates, enzyme substrate complex, enzyme substrate labeled immunoassay.

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1274 GLYCOZYME, INC.

President/CEO: John C. Klock, M.D. Subsidiary of BioMarin

Add: 17935 Sky Park Circle Suite E. Irvine, CA 92614-6321 Tel: (949) 261-9664

R&D expertise: Research of kits enzymes, imagers and software for carbohydrate analysis; products manufacture.

FAX- (949) 261-9078

Technological expertise: Q, E, CB, CH/S

E-mail: [email protected]

Principal products/instrumentation: Glycosep HPLC for analysis of glycoproteins and Glycoconjugates-n-glycanase and other glycosidases. Carbohydrate Standards.

Web site: www.glycozyme.com President/CEO: Allen K. Murray, Ph.D. Research director: Allen K. Murray, Ph.D. R&D expertise: Development of polysaccharides, glycoconjugates, glycoproteins, glycosidases, glycosyltransferases. Plant growth, and cotton fiber; textile cotton fabric chemistry, research and products manufacture.

Main products/instrumentation under R&D: Software for carbohydrate analysis, enzyme immunoassay.

1276 GMP LABELING, INC.

R&D collaboration: USDA, AMGEN, Getty Conservation Institute, USOC, Cotton Incorporated.

Add: 525 West Remington Dr. Sunnyvale, CA 94087

Technological expertise: E, CB, P/S, SY

Tel: (408) 522-3200

Principal products/instrumentation: Plant growth monitoring — cotton, analysis — all cellulose containing materials.

Fax: (408) 522-3212

Main products/instrumentation under R&D: Specific detection of recombinant products, preclinical; variety selection of crop plants, specific analysis of crop plants for development and environmental stress — drought stress, plant growth monitoring, cotton development monitoring.

President/CEO: Bill Sayre

Sealed and granted patents: Method for monitoring growth and detection of environmental stress in plants.

Principal products/instrumentation: GMP Labels™, GMP Signs™, GMPrint Software™, Laser Print GMP LP Labels, GMProcedures™ SOPs.

1275 GLYKO, INC.

E-mail: [email protected] Web site: www.gmplabeling.com R&D expertise: Development of regulatory compliance labeling for use in pharmaceutical, medical device and diagnostic industries, related products manufacture. Technological expertise: CH/S, GP

Main products/instrumentation under R&D: Regulatory compliance labeling of medical devices.

Add: 11 Pimentel Ct. #B Novato, CA 94949-5608 Tel: (415) 884-6799 Fax: (415) 382-3511

1277 GOODWIN BIOTECHNOLOGY, INC.

E-mail: [email protected] Web site: www.glyko.com

Add: 1850 N.W. 69th Ave. Plantation, FL 33313

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Tel: (954) 321-5300 Fax: (954) 587-6378 E-mail: [email protected] Web site: www.goodwinbio.com President/CEO: Stephanie C. Finnegan Research director: Dr. J. Rebbeor R&D expertise: Therapeutics development and products manufacture. Key sales market contracts: Goodwin Institute for Cancer Research (GICR). Key license and trade contracts: Goodwin Institute for Cancer Research (GICR). Technological expertise: T, BA, C/TC, P/S Principal products/instrumentation: Cancer therapeutics, vaccines, biological. Subsidiary bodies: Virginia sales/executive office; California sales office.

1278 GPC BIOTECH AG Add: Fraunhoferstrasse 20 Martinsried 82152 Germany

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Technological expertise: AF, BI, C/TC, COC, CH/S, E, GT, G, HTDS, PB, PIS, RD, R Main products/instrumentation under R&D: CDK inhibitors for cancer, Phase I; p27/pl6 gene therapy for restenosis and cancer, preclinical; cell wall integrity inhibitors for fungal infections, lead optimization; monoclonal antibodies for cancer, lead optimization; antibodies and peptidomimetics for immunology, lead optimization; Angiogenesis inhibitors for cancer, lead optimization. Novel targets of unknown function for antibiotics, assay development. Subsidiary bodies: GPC USA, Inc. Deer Park Drive, Suite 0, Monmouth Junction, NJ 08852; One Kendall Square Bldg. 600, Cambridge, MA 02139. Sealed and granted patents: Over 40 issued patents and over 120 patents pending with a leading position in cell cycle technologies; components of ubiquitin ligase complexes and uses related thereof, 6,747,128, U.S.

1279 GRADIPORE, LTD.

Tel: (49) 89-8565-2600 Fax: (49) 89-8565-2610 E-mail: [email protected] Web site: www.gpc-biotech.com President/CEO: Bemd Sezinger, M.D., Ph.D. Research director: Sebastian Meier-Eweb, Ph.D.; Muzam-mil Mansuri, Ph.D. R&D expertise: Drug design development for cancer, infectious disease and immunology, related products manufacture. R&D collaboration: Aventis, BASF, Bayer, DuPont, Byk Gulden, Boehringer Ingelheim, Cell Genesys, Cytovia (Maxim), Karo Bio, MorphoSys, Evotec, Atugen, Gene Alliance. Key license and trade contracts: Genetica, Inc. Cold Spring Harbor Lab, Fred Hutchinson Cancer Research Center, Massachusetts General Hospital.

Add: Riverside Corporate Park 35-105 Delhi Rd., North Ryde, NSW 2113 Australia Tel: (61) 2-9878-2777 Fax: (61) 2-9805-0625 E-mail: [email protected] Web site: www.gradipore.com.au President: John Manusu Research director: Dennis Rylatt R&D expertise: Research of electrophoresis and hematology, novel products manufacture. R&D collaboration: CSIRO, Westmead Hospital, University of Melbourne, Macquarie University. Key sales market contracts: E. Merck, Instrumentation Labs, Intermountain Scientific, Eppendorf GmbH, Behring AG and Organon Technika.

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Technological expertise: P/S, BS

1282 GREENTECH

Principal products/instrumentation: Microgels electrophoresis precast gels, pocket-gels, precast gels with sample wells, Lupo-test Lupus anticoagulant assay, Gradiflow preparative electrophoresis.

Add: Biopole Clermont-Limagne Puy-deDome Saint Beauzire, Cedex F-63360 France

Main products/instrumentation under R&D: Gradiflow large-scale separation process, prototype.

E-mail: [email protected]

Tel: (33) 4-7364-4345 Fax: (33) 4-7333-9132 President: J. Y. Betthon R&D expertise: G. Iung

1280 GRANBIO, INC. Add: P.O. Box 892140 Temecula, CA 925892140 Tel: (909) 676-0049 President: David J. Granlund, Ph.D.

Research director: R&D of biotechnology medicines and products from selected plants or microorganisms. Joint ventures: Biotechnology companies, OCTOTECH GIE, The Biopole ClermontLimagne.

R&D expertise: Viral diagnostics, development and novel products manufacture.

R&D collaboration: Research laboratories of Auvergne University; University of Barcelona (Italy); University of Liege (Belgium).

Technological expertise: RD, C/TC, H/CF, P/S

Technological expertise: F, TE, T, BA, C/TC, D-D

Principal products/instrumentation: Epsteinbarr virus diagnostic kits (both IFA and EIA), diagnostics, reagents.

Principal products/instrumentation: Artemisinin, Ceramids, DNA protector, sweetener probiotics.

1281 GRASEBY Add: 500 Technology Ct. Smyrna, GA 30082

Main products/instrumentation under R&D: Contract research/clinical trial products, cosmetics, natural products, enzyme, polysaccharide therapeutic proteins.

Tel: (770) 319-0336 Fax: (770) 319-0336

1283 GREINER AMERICA, INC.

E-mail: [email protected] Web site: www.graseby.com President: Dave Morell R&D expertise: Development of air quality monitoring equipment, related products manufacture.

Add: P.O. Box 963279 Lake Mary, FL 32795 Tel: (800) 884-4703 Fax: (407) 333-3001 E-mail: [email protected] Web site: www.greineramerica.com

Technological expertise: AU, R

President: Heinz Schmid

Principal products/instrumentation: Air monitoring systems.

R&D expertise: Design, development and production of biomedical laboratory instrumentation.

Main products/instrumentation under R&D: Air washer, air quality monitoring equipment.

Technological expertise: H/CF, C/TC, HTDS

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Principal products/instrumentation: Plastic microplates, tissue culture (TC) flask and disk. Main products/instrumentation under R&D: Biomedical laboratory instruments for pharmaceutical research, labwares.

1284 GROPEP LIMITED

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whey-derived growth factors, fish growth factors; collaborative clinical product development and GMP manufacturing at prototype scale. IGFs and analogues, EGF and related growth factors, catalogue available. Main products/instrumentation under R&D: Insulin-like growth factor binding proteins (IGFBPs) and rat IGF-II. Growth factors, antibodies, receptors.

Add: P.O. Box 10065 Gouger St. Adelaide 5000 South Australia

Subsidiary bodies: GMP manufacturing facility.

Tel: (61) 8-8354-7709; (61) 8-8354-7700

Sealed and granted patents: Growth-promoting agent, 7,033,134, U.S.; Mammalian milk growth factor, 6,531,134, U.S.

Fax: (61)8-8354-7788 E-mail: [email protected] Web site: www.gropep.com.au President/CEO: Dr. F. J. Ballard

1285 GROUP LOGIC, INC.

Research director: G. L. Francis R&D expertise: Development of cell and tissue culture other biotechnology medicines; related products manufacture. R&D collaboration: Nestle, Mayo Clinic, International Diabetes Institute, Cooperative Research Centre (CRC) for Tissue Growth and Repair. Key sales market contracts: JRH Biosciences. Joint ventures: CSIRO, Universityof Adelaide CHRI, Flinders University Key license and trade contracts: JRH Biosciences, Mayo medical Ventures, CRC for Tissue Growth and Repair. Technological expertise: F, PA, RD, C/TC, PIS Principal products/instrumentation: Insulinlike growth factor analogs and antibodies, rat IGF-binding proteins, epidermal growth factor (EGF) TGF analogs and antibodies, rat IGFs, chicken IGFs and antisera, IGF and antisera, IGF-binding proteins, epidermal growth factor (EGF), TGFs antisera, nerve growth factor (NGF) and insulin-like growth factors, cell culture growth factor specific antibodies,

Add: 1408 N. Fillmore St. #10 Arlington, VA 22201~22203 Tel: (703) 528-1555; (703) 528-7555 Fax: (703) 528-3296 E-mail: [email protected] Web site: www.grouplogic.com President/CEO: Reid Lewis Research director: Derek Napf R&D expertise: Biotechnological software development. R&D collaboration: PE Bio, Texco. Technological expertise: Q, BI, CH/S, G Principal products/instrumentation: Bioinformatics software, mass transit, human genome project. Main products/instrumentation under R&D: Novel drug development software.

1286 GRYPHON SCIENCES Add: 250 E. Grand Ave. Suite 90 South San Francisco, CA 94080 Tel: (650) 952-7714

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Fax: (650) 952-3055

1288 GUILDHAY LIMITED

E-mail: [email protected] Web site: www.gryphonsci.com President/CEO: Stephen B. H. Kent R&D expertise: Custom chemical synthesis and manufacture of proteins and protein analogues as research reagents and for research and development collaborations. Technological expertise: D-D, PIS, SY Principal products/instrumentation: Contract manufacturing products, reagents, vaccines, proteins, site-specifically modified protein analogues (including biotinylated and fluorescently tagged, non-coded amino acid substituted proteins), protein families, protein small molecule conjugates and other protein analogues.

Add: 6 Riverside Business Centre Walnut Tree Close Guilford, Surrey GUI 4UG UK Tel: (44) 148-357-3727 Fax: (44) 148-357-4828 E-mail: [email protected] Web site: www.guildhay.co.uk President/CEO: Keith Page R&D expertise: Research, design, development and manufacture of immunoassays and antibodies for food, veterinary and environmental applications. Technological expertise: PA, C/TC, H/CF

Main products/instrumentation under R&D: Peptide Vaccines, preclinical — in collaboration with academic institutions; AGRP reagents, chemokines, custom chemical synthesis products of proteins.

Principal products/instrumentation: Contract manufacturing products, food processing products, pesticides, reagents, veterinary avian diagnostics, Flockscreen, environmental diagnostics, aquascreen, porcine diagnostics, PorSign, veterinary diagnostics, VetSign.

Sealed and granted patents: Site specific modification of proteins (two issued internationally), approximately 14 others in prosecution, chemical protein synthesis and others.

1289 GUILFORD PHARMACEUTICALS, INC. Add: 6611 Tributary St. Baltimore, MD 21224

1287 GTF CELLTOX AB Add: Sodra Langebergsgatan 30 Vastra Frolunda Goteborg S-421 32 Sweden

Tel: (410) 631-6300 Fax: (410) 631-6338 E-mail: [email protected]

Tel: (46) 3168-0490

Web site: www.guilfordpharm.com

Fax: (46) 3168-0717

President/CEO: Craig R. Smith, M.D.

President/CEO: Peter Sandberg

Research director: Peter Suzdak

Research director: Anders Peterson, Ph.D.

R&D expertise: Research, development and manufacture of novel products in two main areas: targeted and controlled drug delivery systems using proprietary biodegradable polymers for the treatment of cancer and other diseases and products for the diagnosis, treatment and prevention of neurological disorders; related novel products manufacture.

R&D expertise: Research of in vitro toxicology testing, testing program design and products development. Technological expertise: H/CF, C/TC, HTDS Principal products/instrumentation: In vitro toxicology testing, monoclonal antibody, drug screening route.

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Joint ventures: Rhone-Poulenc Rorer, Daiichi Radioisotope Laboratories, Orion-Farmos. Technological expertise: DD, D-D, DDI Principal products/instrumentation: CITADEL® wafer. Main products/instrumentation under R&D: GLLADEL® to treat brain cancer, Phase II; Other polymer-drug products — cancer (prostate, breast etc.), research; DOPASCAN™ — diagnostic for Parkinson’s disease, Phase IIB; Neuroimmunophilin ligands, preclinical; presynaptic glutamate modulation — stroke, research; NOS inhibitors — stroke, research; PARS inhibitors — stroke, research; Cocaine antagonist — cocaine addiction, research; GPI3000 (NMDA antagonist) — stroke, head trauma, preclinical.

1290 GYNELOGIX, INC.

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President/CEO: Dr. Hartmanis Research director: Mr. Ehmstrom/Annika Lindgren R&D expertise: Product development and manufacture of integrated microfluidic based bioanalysis system for life sciences and diagnostics. Technological expertise: BI, C/TC, D-D, G, HTDS, H/CF, P/S, PIS Main products/instrumentation under R&D: Integrated microfluidic systems, bioanalytic instrumentation, in vitro toxicology testing reagents. Sealed and granted patents: Many.

1292 H+P LABORTECHNIK GMBH Add: Bruckmannring 28 Oberschleissheim 85764 Germany

Add: 280 S. Taylor Ave. Suite 100 Louisville, CO 80027

Tel: (49) 89-315-8220

Tel: (303) 926-8454

E-mail: [email protected]

Fax: (303) 926-8471

Web site: www.hp-lab.de

E-mail: [email protected]

President/CEO: Dr. Herz

President/CEO: Gerald L. Chrisope R&D expertise: Development of women special drug, products manufacture.

R&D expertise: Development and manufacture of biomedical equipment and instrumentation.

Technological expertise: F

Technological expertise: COC, C/TC, BME

Main products/instrumentation under R&D: Vaginal health product, Phase II; vaginal suppository, vaginal cream, vaginal gel, other women special drugs.

Principal products/instrumentation: VARIOKLAV steam sterilizers; VARIOMAG electronic stirrers, VARIOMAG reaction blocks.

Fax: (49) 89-315-4453

1293 HABER, INC. 1291 GYROS MICROLAB

Add: 470 Main Rd. Towaco, NJ 07082

Add: Dag Hammerskjold 52 75183 Sweden

Tel: (201) 263-0990

Tel: (46) 18-56-6300

Fax: (201) 263-9296

Fax: (46) 18-56-6350

E-mail: [email protected]

Web site: www.gyrosmicro.com

President/CEO: Norman Haber

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Research director: Norman Haber and Dr. Henry E. Rosenberg R&D expertise: Development of electromolecular propulsion (EMP) instruments, protocols, analytical/separation technology for dyes, biostains, proteins, DNA, etc. Technological expertise: P/S, LP, C/TC, small-scale purification, electromolecular propulsion, electrochemical research. Principal products/instrumentation: EMP instruments and reagents, specialty chemicals. Sealed and granted patents: EMP process, specialty chemicals, small-scale purification, electromolecular propulsion, electrochemical research.

Sealed and granted patents: Mucosal immunization against hepatitis A virus (HAV) through rectal administration of HAV vaccine; 6,368,602. U.S.; Serum-derived factor inducing cell differentiation and medical uses thereof, 6,372,262, U.S.; Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII for binding cells, 6,503,731, U.S.; B-cell epitope peptides of HSP65, 6,770,281, U.S.

1295 HAEMACURE CORPORATION Add: 16771 Chemin Ste-Marie Kirkland, Quebec H9H 5H3 Canada Tel: (514) 426-7181 Fax: (514) 630-7756 Web site: www.haemacurecorp.com

1294 HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPEMENT CO. LTD. Add: Kiryat Hadassah P.O. Box 12000 Jerusalem 91120 Israel Tel: (972) 2-643-7550; (972) 2-677-8757 Fax: (972) 2-643-7712 E-mail: [email protected] Web site: www.hadasit.co.il President/CEO: Prof. Avi Israeli Research director: Raphael Hofstein, Ph.D. Subsidiary of Hadassah Medical Organization R&D expertise: Development, manufacture and commercialization of the intellectual property and the applied R&D activities at Hadassah Medical Organization (HMO). Technological expertise: RD, AF, C/TC, DD, GA, GT, PIS, PG Main products/instrumentation under R&D: Contract development products, HAV vaccine to treat hepatitis A virus, Fibrin microbeads, B-cell epitope peptides.

President/CEO: Marc Paquin Research director: Kevi Hahnen R&D expertise: Development and manufacture of virally inactivated, commercially available fibrin sealant. Key license and trade contracts: New York Blood Center (NYBC), NY, Rinrone, SBSI, Immuno International AG. Technological expertise: BA, P/S Principal products/instrumentation: Hemaseel APR. Main products/instrumentation under R&D: Biologic adhesives, R&D. Subsidiary bodies: Sarasota, Florida.

1296 HAEMATOLOGIC TECHNOLOGIES, INC. Add: Box 1021, 57 River Rd. Essex Junction, VT 05452 Tel: (802) 878-1777 Fax: (802) 878-1776 E-mail: [email protected]

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Web site: www.haemtech.com.

E-mail: [email protected]

President/CEO: Richard J. Jenny

Web site: www.hamiltoncompany.com

Research director: Richard J. Jenny

President/CEO: Steve Hamilton

R&D expertise: Manufacture and development of coagulation research reagents and contract research related to blood coagulation.

R&D expertise: Manufacture and marketing of biomedical laboratory instrumentation for drug research.

Technological expertise: E, P/S, BA, C/TC

Technological expertise: F, HTDS, PMC, P/S, R, HC, BME, DKHC

Principal products/instrumentation: Contract manufacturing products, contract research/clinical trial products, Human Factor X/XA, Bovine Factor X/XA, human thrombin, bovine thrombin.

Principal products/instrumentation: Robotics, syringes, valves, dispensers, electrodes, HPLC columns; pipettes; microlab STAR (automatic pipetting workstation), 2007.

Main products/instrumentation under R&D: Coagulation research reagents, coagulator. 1299 HAMILTON THORNE RESEARCH 1297 HAEMO-SOL, INC.

Add: 100 Cummings Center Ste. 102C Beverly, MA 01915

Add: 7301 York Rd. Towson, MD 21204

Tel: (978) 921-2050

Tel: (410) 821-5676

Fax: (978) 921-0250

Fax: (410) 828-8461

E-mail: [email protected]

E-mail: [email protected]

Web site: www.hamiltonthorne.com

Web site: www.haemo-sol.com

President/CEO: Margaret Douglas-Hamilton

President/CEO: Stephen Kempe

Research director: Diarmaid Douglas-Hamilton

Research director: William L. Hermann R&D expertise: Development and manufacture of specialized detergents.

R&D expertise: Medical, biotechnology and toxicology markets. Research and novel products development.

Technological expertise: COC, E, ET, EAT

Technological expertise: Q, GA

Principal products/instrumentation: HaemoSol detergents: Haemo-Sol Regular, HaemoSol Non-phosphate; Haemo-Sol Non Sudsing; Haemo-Sol Enzyme Active.

Principal products/instrumentation: Multiple products for fertility diagnostics, including HTM-IVOS, HTM-CEROS, Gene Diagnostics and HTR-Beacons.

Main products/instrumentation under R&D: Specialized detergents.

1298 HAMILTON COMPANY

1300 HAMOSAN GESMBH Add: Neudorf 41 Styria A-8262 ILZ Austria Tel: (43) 3385-8117; (43) 316-681713-2021

Add: 4970 Energy Way Reno, NV 89502

Fax: (43) 3385-824344; (43) 3166-81713

Tel: (775) 858-3000; (800) 648-5950

President/CEO: Herwig Reichl

Fax: (775) 856-7259

Research director: Herwig Reichl

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R&D expertise: Research and products development of bovine serum albumins, virus inactivation in biological material, filtration technology. Technological expertise: LP, P/S, BA, PMC, virus inactivation, prion inactivation. Principal products/instrumentation: Virusand BSE-free BSA Hamosafe, technology for virus inactivation in biological material Hamosafe®. Main products/instrumentation under R&D: Virus-safe factor VIII (preclinical, still looking for partners), technology for virus inactivation in biological materials. Sealed and granted patents: Virus and prion inactivation.

Fax: (306) 773-0066 E-mail: [email protected] Web site: www.haraproducts.com President/CEO: Ron Juffinger R&D expertise: Development and manufacture of thermoplastic injection molding. Technological expertise: CW, COS Principal products/instrumentation: “Hara” insect trap, Bait. Main products/instrumentation under R&D: Therapeutic injection molding.

1303 HARDY DIAGNOSTICS Add: 1430 West McCoy Lane Santa Maria, CA 93455

1301 HAMPSHIRE CONTROLS CORP.

Tel: (800) 266-2222 Fax: (805) 346-2760

Add: One Grove St. P.O. Box 516 Dover, NH 03821 Tel: (603) 749-9424 Fax: (603) 749-9433

E-mail: [email protected] Web site: www.hardydiagnostics.com President/CEO: Jay Hardy

Web site: www.hampshirecontrols.com

R&D expertise: Microbiology research and laboratory reagents, labwares, media development and manufacture.

President/CEO: Anthony Consentino

Technological expertise: F, CW

R&D expertise: Development and manufacture of temperature monitors/alarms.

Principal products/instrumentation: Contract manufacturing products, prepared culture media, dehydrated culture media, reagents/stains/test kits for microbiology.

E-mail: [email protected]

Technological expertise: CH/S Principal products/instrumentation: Model 125 Singleprobe temperature monitor/alarm; Model TS4 Multi-probe temperature monitor/ alarm; Model AFM-Air flow monitor; Model 125-200R LN(2) temperature monitor/alarm.

Main products/instrumentation under R&D: Laboratory professional reagents, labwares, biotech wares. Subsidiary bodies: Phoenix and Salt Lake City warehouses.

1302 HARA PRODUCTS, LTD. Add: P.O. Box 134 Stn. Main Swift Current, Sask. 59H 3V5 Canada Tel: (306) 773-2131

1304 HARLAN BIOPRODUCTS Add: FOR SCIENCE, INC. P.O. Box 29176 Indianapolis, IN 46229-0176

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Tel: (317) 894-7536 Fax: (317) 894-9458 E-mail: [email protected] Web site: www.harlan.com President/CEO: Hal P. Harlan Research director: Rook Khajenouri R&D expertise: Bioprocess engineering research, cell and tissue culture, other biotechnology medicines development. Technological expertise: PA, P/S, LP, PMC, BA, C/TC, H/CF Principal products/instrumentation: Monoclonal and polyclonal antibodies; cytokines and growth factors; monoclonal antibody production; hybridoma development; organs, glands, and tissues; fetal bovine serum; rat, mouse and guinea pig serum; monoclonal and polyclonal antibodies of human, rat, mouse CD antigens; growth factors; murine cytokines and endothelial products; custom monoclonal antibody production; custom rodent tissue; custom rodent sera. Main products/instrumentation under R&D: Cell and tissue culture, biotechnology medicines, bioprocess engineering technology.

1305 HARLAN SERA-LAB, LTD.

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Technological expertise: F, PA, P/S, BA, H/CF, C/TC Principal products/instrumentation: Sera and cell culture reagents, contract sera and antibodies production and services. Main products/instrumentation under R&D: Monoclonal and polyclonal antibodies, plasma expander, plasma substitude blood.

1306 HARRIS DIAMOND CORP. Add: 11 High Street, P.O. Box 130 Newton, NJ 07860 Tel: (973) 770-1420 Fax: (973) 770-1549 President/CEO: Leonard Harris R&D expertise: Development and supply of diamond products manufactured by Drukker International B.V. Technological expertise: BME Principal products/instrumentation: Drukker Diamond Ultramicrotome knives, blades, windows, anvils, heat sinks, cleavers, specialty tools.

1307 HARRIS FRC CORPORATION

Add: Hilkrest Research Station Dodgeford Lane, Leicestershire Belton, Loughborough LE12 9TE UK

Add: 2139 Route 35 Holmdel, NJ 07733

Tel: (44) 01530-222123

Fax: (732) 739-0713

Fax: (44) 01530-224970

E-mail: [email protected]

E-mail: [email protected]

President/CEO: Robert H. Harris, Ph.D.

Web site: www.harlanseralab.com

Research director: Robert H. Harris, Ph.D.

President/CEO: H. P. Harlan

R&D expertise: Pharmaceuticals/biotech medicines research and consulting, and product development.

Research director: Kelly Sapsford R&D expertise: Development of immunology products, including monoclonal and polyclonal antibodies, sera and cell culture reagents, plasma, blood products, contract monoclonal and polyclonal products.

Tel: (732) 739-2018

Key license and trade contracts: Schwarz Pharma (Harkoseride). Technological expertise: SMC, COC, DD, D-D, H/CF

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Main products/instrumentation under R&D: Contact research/clinical trial products. Harkoseride (ADD234037), Phase II, biotech medicines, labwares, biotech wares.

1308 HARRIS GROUP, INC. Add: 1000 Denny Way, Suite 800 Seattle, WA 98109 Tel: (206) 494-9400

Technological expertise: P/S, CH/S, PMC Main products/instrumentation under R&D: Bioremediation, contract manufacturing products, cosmetics, detergents, food processing, laboratory instrumentation, pharmaceuticals, process validation, toxic waste processing method, start-up systems in biotech industries.

1310 HARTGE INGREDIENTS, GMBH

E-mail: [email protected]

Add: Georgsplatz 6 Hamburg D-20099 Germany

Web site: www.harrisgrp.com

Tel: (49) 40-3330-5930

President/CEO: Robert Harris

Fax: (49) 40-32-6498

R&D expertise: Full service engineering firm of novel pharmaceutical R&D and manufacture.

E-mail: [email protected]

Fax: (206) 494-9500

Technological expertise: F, SMC, P/S, BA, C/TC, PMC, CH/S, SY, AB, PIS Principal products/instrumentation: Experience and technologies of R&D, including front-end feasibility studies, pilot plants, scaleup, detailed design, procurement construction management.

1309 HARTEL DIVISION

R&D expertise: Cell and tissue culture, other biotechnology medicines. Technological expertise: C/TC, F, PC Key sales market contracts: Marcor Development Corp., Naturex SA, Aromes De Bretagne. Principal products/instrumentation: Specialty biochemicals; essential oils; protein hydrolysates and peptones; culture media ingredients; fermentation nutrients; fine chemicals; malt extract; beef extract; egg powder; antioxidants; raw materials for cosmetic and pharmaceutical industry.

Add: 201 North Main St. Fort Atkinson, WI 53538 Tel: (920) 563-8461

1311 HARVARD APPARATUS, INC.

Fax: (920) 563-0157 E-mail: [email protected] Web site: www.hartelcorp.com President/CEO: Bob Cadwalader Subsidiary of Advanced Separations and Process Systems, Lnc. R&D expertise: Custom research and manufacture of fabricator that designs, engineers, fabricates and starts up systems in biotech, pharmaceutical, chemical, cosmetic, food and dairy industries.

Add: 84 October Hill Rd. Holliston, MA 01746-1308 Tel: (508) 893-8999 Fax: (508) 429-5732 Web site: www.harvardapparatus.com President/CEO: David Green R&D expertise: Research and manufacture of bioscience/life science products, including peristaltic pumps, respirators, physiological equipment, microdialysis.

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Technological expertise: DD, P/S, G

Tel: (808) 486-5333

Principal products/instrumentation: Microprocessor syringe infusion and peristaltic pumps, microdialysis probes (patent pending); complete line of microdialysis products, molecular biology products.

Fax: (808) 487-7341

Subsidiary bodies: Harvard Apparatus Ltd., Fircroft Way, Edenbridge, Kent TN8 6HE UK, Tel: (44) 73-286-4001, Fax: (44) 0173-286-3356; Ealing Scientific Ltd., 6010 Vandee Abeele St., St. Laurent, Quebec H4S 1R9, Canada, Tel: (514) 335-0792, Fax: (514) 335-3482; Ealing S.A.R.L, 6 Ave. des Andes, Minipare — Bat 8, 91952 Les Ulis Cedex, France, Tel: (33) 1-6446-2500, Fax: (33) 1-6446-9438; HSE-Harvard, Gruenstrasse 1D-79232, March-Hugstetten, Germany, Tel: (49) 76-659-2000, Fax: (49) 76-659-2009.

Research director: Julia Leung, Ph.D.

1312 HAUSER LABORATORIES Add: 5555 Airport Blvd. Boulder, CO 80301 Tel: (303) 443-4662 Fax: (303) 441-5803 E-mail: [email protected] Web site: www.hauser.com President/CEO: Dean P. Stull, Ph.D. R&D expertise: Full service research, design, development and testing lab specializing in chemistry, engineering, materials science and consumer products. Technological expertise: CC, D-D, SY, COC, P/S Principal products/instrumentation: Pharmaceuticals, process validation, contract manufacturing products, natural products, nutraceuticals.

1313 HAWAII BIOTECHNOLOGY GROUP, INC. Add: 99-193 Aiea Heights Dr. Suite 236 Aiea, HI 96701

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E-mail: [email protected] Web site: www.hibiotech.com President/CEO: Tom Humphreys, Ph.D. R&D expertise: Research and services of biotechnology; vaccine and other drugs development/manufacture. Technological expertise: C/TC, GA, G, P/S, RD, T, AF, COC, DD, H/CF, SY Principal products/instrumentation: Contract research products, Taxol immunoassay kits, Taxane immunoassay kit; Dengue virus AGS. Main products/instrumentation under R&D: Dengue subunit vaccine, influenza recombinant subunit vaccines, diagnostic devices, nonaqueous solvent specific-binding protein assays, immunogenic composition of hepatitis C. Sealed and granted patents: Subunit vaccine against dengue infection — being issued U.S. patent 08/937,195; Process for affinity purification by immunoadsorption in non-aqueous solvent U.S. patent No. 5,364,531; Non-aqueous solvent specific-binding-protein assays — U.S. patent No. 5,118,607; Coffee Bean aGalactosidase cDNA for recombinant enzyme expression — U.S. patent No. 08/l13,890; Immunogenic composition of hepatitis C and methods of use thereof, 6,682,909, U.S.; influenza recombinant subunit vaccine, 20080008722, U.S.

1314 HAYAT LABORITORIES SUPPLIES TRADE AND IND. INC. Add: Vatan Cad. Emlak Bank Konutlari C1 D:2 Fatih Istanbul 34250 Turkey Tel: (90) 212-621-6260 Fax: (90) 212-621-7053

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E-mail: [email protected]

President/CEO: Eli Hadomi

Web site: www.hayat-inc.com

Research director: Dr. Eyal Vardi

President/CEO: Abourrahman Ibrikci Research director: Hakan Ibrikci

R&D expertise: Development and manufacture of hi-tech seeds.

R&D expertise: Development and manufacture of in vitro diagnostic products.

R&D collaboration: Research agreements with Israeli research institutes and universities.

Key sales market contracts: Dako A/S, Biocode, DSL, Innovex.

Technological expertise: Q, BI, C/TC, CH/S, GA

Technological expertise: PA, BME, F

Principal products/instrumentation: Agriculture, hybrid seed of greenhouse tomatoes with extended shelf life.

Principal products/instrumentation: Clinical immunochemistry products, flow cytometry products, Immunochemistry products, in situ hybridization products, RIA, IRMA, ELISA products, DSL, Biocode.

Main products/instrumentation under R&D: Hi-tech seeds.

1317 H.D. BAUMANN, INC. 1315 HAZAMA CORP.

Add: 35 Mirona Rd. Portsmouth, NH 03801

Add: 5-8 Kita-aoyama 2-chome Minato-ku, Tokyo 107 Japan

Tel: (603) 436-2044

Tel: (81) 03-3405-1111 Fax: (81) 03-3405-1878

Web site: www.frco.com/fisher/products/ lowslow.dgw

President/CEO: Matsumoto Mikio

President/CEO: Steve Pelch

Research director: Saida Toyoyasu

Subsidiary of Fisher Controls International, Inc.

R&D expertise: Research of civil engineering, building and architectural projects, urban development, real estate and design.

Fax: (603) 436-4901

R&D expertise: Development, and manufacture of capital equipment and control valves.

Joint ventures: Marine Biology Institute.

Technological expertise: PMC

Technological expertise: BME

Principal products/instrumentation: Mikroseal, 84,000 series, Flexsleev, Rotosleev, Lo-T.

Principal products/instrumentation: Engineering and construction of civil works and architecture, including clean rooms, AMP facilities.

Main products/instrumentation under R&D: Capital equipment for lab drug research.

1318 H.D. SUPPLIES 1316 HAZERA (1939), LTD. Add: Brurim D.N. Shikmim 79837 Israel

Add: 44 Rabans Close Rabans Lane Industrial Estate Aylesbury, Bucks HP19 3RS UK

Tel: (972) 8-850-8850

Tel: (44) 129-643-1920

Fax: (972) 8-850-2404

Fax: (44) 129-639-2121

E-mail: [email protected]

President/CEO: C. W. Hawkins

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R&D expertise: Research, development, manufacture and supply of medical diagnostic reagents. Technological expertise: PA, P/S, COC Main products/instrumentation under R&D: Medical diagnostic reagents, contract manufacturing products, reagents for biology research. 1319 HEALTHY OPTIONS Add: 150 Kingsberry Drive Somerset, NJ 08873 Tel: (732) 846-1362 Fax: (732) 846-0639 Web site: www.roadstohealth.com President/CEO: Sharon Moore Subsidiary of Rexall Showcase Interational R&D expertise: Development, manufacture and distribution of natural products. Key sales market contracts: Rexall Sundown Key license and trade contracts: Rexall Showcase International Technological expertise: D-D, CB, PG, DD Principal products/instrumentation: Natural products, BiosLife 2, Cellular Essentials, Meno-Basics, Body Synergy. Subsidiary bodies: Boca Raton, FL; Las Vegas, NV; Hong Kong; Taiwan; Mexico City, Mexico; Korea; Singapore; Japan. Sealed and granted patents: BiosLife2, two patents. 1320 HEIDOLPH INSTRUMENTS GMBH & CO. Add: Waldersdorfer Str. 12 Schwabach 91126 Germany Tel: (49) 9122-99200 Fax: (49) 9122-992065 E-mail: [email protected] Web site: www.heidolph.com President/CEO: Dr. Ing. R. Zinsser Research director: Guenther Vollgold

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R&D expertise: Development and manufacture of laboratory biomedical equipment. Technological expertise: BME Principal products/instrumentation: Laboratory equipment, evaporators, dispensers, overhead mixers, magnetic stirrers, electronic stirrers, pumps, centrifugal and peristaltic, baths, hot plates. Main products/instrumentation under R&D: Laboratory biomedical novel instruments/ equipment.

1321 HELENA BIOSCIENCES Add: Colira Ave. Sunderland Enterprise Par Sunderland SR5 3XB UK Tel: (44) 0 191-549-6064 Fax: (44) 0 191-549-6271 E-mail: [email protected] President/CEO: M. J. Stephenson R&D expertise: R&D, design and manufacture of electrophoresis, molecular and cell biology, immunochemistry, haemostasis, laboratory hardware. Technological expertise: RD, BI, C/TC, CH/S, GA Principal products/instrumentation: Organ transplants/culture products, REP system, platelet investigation system, Titan gel electrophoresis. Main products/instrumentation under R&D: Pre sasy DNA gels, Phase I.

1322 HELIX BIOPHARMA CORP. Add: 3-305 Industrial Pkwy S. Aurora, Ontario L4G SV3 Canada Tel: (905) 841-2300 Fax: (905) 841-2244 Web site: www.helixbio.com President: Dr. D. Segal; CEO: Mr. J. McElroy

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Research director: Dr. Marianna Foldvari

Tel: (44) 0171-383-5721

R&D expertise: Development of drug design and drug delivery technology; products manufacture.

Fax: (44) 0171-380-7018

Joint ventures: VIDO, University of Alberta, PENCE. R&D collaboration: In discussion with several drug development partners. Technological expertise: D-D, DD Main products/instrumentation under R&D: Pharmaceuticals, vaccines, contract development products, drug delivery technology, BIPHASIX. Subsidiary bodies: Pharmaderm Laboratories, Saskatoon. Sealed and granted patents: BIPHASIX®, drug delivery technology. 1323 HELIX BIOTECH Add: 635 Columbia Street New Westminster, B.C. V3M 1A7 Canada

E-mail: [email protected] Web site: www.biochem.ucl.ac.uk/helix President/CEO: Dr. John Ward Research director: Dr. Don Cowan R&D expertise: Development/research of ermines and products of technologies for industrial and environmental processes, products manufacture. R&D collaboration: UK Government (DTI) Development Grant. Technological expertise: CC, E, F, RD, P/S Principal products/instrumentation: Bioremediation, contract research/clinical trial products, natural products, reagents, Bug-Bank, Helix’s extensive collection of microbial isolates. Main products/instrumentation under R&D: Enzyme substrate complex, technology for production of novel clinical nutrition product.

Tel: (604) 523-2945; (800) 563-4363 Fax: (604) 523-2974

1325 HELIX SCIENTIFIC, INC.

E-mail: [email protected] Web site: www.helixbiotech.com

Add: P.O. Box 2386 Warminster, PA 18974

President/CEO: Dr. Terrance G. Owen

Tel: (215) 953-1990

Subsidiary of Lifecodes Corp, Stamford, CT.

Fax: (215) 953-1991

R&D expertise: DNA testing program development.

E-mail: [email protected]

Key license and trade contracts: Lifecodes Corp.

Research director: Ron Finlayson

Technological expertise: P/S, RD Main products/instrumentation under R&D: DNA testing program, DNA protein complex, DNA sequence analyzer. 1324 HELIX BIOTECHNOLOGY, LTD. Add: Darwin Building Gower St. London WC1E 6BT UK

President/CEO: Stephen Dewhirst R&D expertise: Cell and tissue culture, other biotechnology medicines. Technological expertise: Q, GA, GT, HTDS Principal products/instrumentation: Thermal cycling instruments; sample evaporation instruments. Main products/instrumentation under R&D: Thermal instruments for robotics, DNA isolation instruments, DNA cloning vector, cell and tissue culture.

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1326 HELLAMCO/MICHAEL CONTOYANNIS Add: 7, Marathonos Str. Chalandri, Athens GR-15233 Greece Tel: (30) 1-689-5260 Fax: (30) 1-680-1672 E-mail: hellamco@compulink President/CEO: Michael Contoyannis Research director: Anastasia Mylonas R&D expertise: Development of biomedical scientific equipment and supplies. Technological expertise: F, Q, COC, P/S, SY, BME Principal products/instrumentation: HPLC, UV-VIS, DNA sequencing, HP Molecular dynamics, protein sequencing, centrifugation, molecular devices, phosphorimaging, densitometry, I.F.C. Savant, capillary electrophoresis.

1327 HELLMA CELLS, INC. Add: 118-21 Queens Blvd. Forest Hills, NY 11375 Tel: (718) 544-9166 Fax: (718) 263-6910 E-mail: [email protected] Web site: www.Hellmausa.com Subsidiary of Hellma GmbH & Co. Inc. R&D expertise: Development and manufacture of laboratory biomedical equipment and labwares. Technological expertise: BME Principal products/instrumentation: Spectrophotometer cells, ultra-micro volume cells, quartz microplates, ultraviolet light sources, gratings, optical components, miniature spectrometers. Main products/instrumentation under R&D: Labware, biotech wares, laboratory-scale purification devices.

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1328 HEMACARE CORPORATION Add: 4954 Van Nuys Blvd., 2nd Fl. Sherman Oaks, CA 91403 Tel: (818) 986-3883 E-mail: [email protected] President/CEO: Hal I. Lieberman R&D expertise: Development and manufacture of blood products and blood. Technological expertise: BS, C/TC Principal products/instrumentation: Human platelet concentrates, RBC, FFP and other blood derivatives. Main products/instrumentation under R&D: Blood substitutes, blood plasma substitute, blood replenisher. Subsidiary bodies: Gateway Community Blood Program, 1880 Craigshire Dr., St. Louis, MO 63146; The USC Blood Center, 2250 Alcazar St., #136, Los Angeles, CA 90033.

1329 HEMA RESOURCE & SUPPLY, INC. Add: 28743 S. Meridian Rd. Aurora, OR 97002 Tel: (503) 651-3572 Fax: (503) 651-3639 President/CEO: William H. Ferris Research director: Derrick Schultz R&D expertise: Development of cell/tissue culture and blood substitutes, manufacture and procurement of animal biologicals from sera and sera fractions. Technological expertise: P/S, BI, C/TC Main products/instrumentation under R&D: Contract research/clinical trial products, diagnostics, food processing, vaccines, veterinary products, cell/tissue culture, blood substitutes.

1330 HEMASURE, INC. Add: 33 LOCKE DR Marlborough, MA 01752

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Tel: (508) 485-6850 Fax: (508) 485-6045 E-mail: hemasure.com President/CEO: Eugene J. Zurlo Research director: Hans Heiniger, Ph.D., D.V.M. R&D expertise: Development and manufacture of blood products and related R&D services. Key sales market contracts: Letter of Intent with Level I Technologies to use HemoNet.

designed to isolate liquid-handling workstations, HPLC equipment, sample weighing, highthroughput screening, powders handling, and other lab-automated processes by providing exhaust air systems, a clean workstation, or temperature-/humidity-controlled environments. The enclosures feature a flexible, modular design and are engineered and built to customer size and design requirements, 2010.

1332 HEMISPHERX BIOPHARMA, INC.

Key license and trade contracts: Clinical Chemistry Consultants, Inc. exclusive worldwide license for proprietary viral inactivation technologies for blood and blood products.

Add: One Penn Center, Suite 660 1617 JFK Blvd. Philadelphia, PA 19103

Technological expertise: E, SY, C/TC, CS, ERT, ET

Fax: (215) 988-1739

Main products/instrumentation under R&D: LeukoNet filter 510 (k), LeukoVir filter; HemoNet filter; Cell washer; Cell concentrator; PlasmaSep plasma collection system, viral inactivation technologies for blood and blood products.

1331 HEMCO CORPORATION Add: 111 Powell Rd. Independence, MO 64056 Tel: (816) 796-2900 Fax: (816) 796-3333 E-mail: [email protected] Web site: www.hemcocorp.com President/CEO: Ronald E. Hill R&D expertise: Specialist research and products manufacture in containment technology. Technological expertise: PMC, R, BME Principal products/instrumentation: Contract manufacturing products, fume hoods, modular rooms, enclosures and clean rooms. Main products/instrumentation under R&D: Recombinant containment technology; Enclosures for Automation are engineered to isolate lab automation equipment and robotic processes while maintaining a safe working area. They are

Tel: (215) 988-0080 President/CEO: William A. Carter, M.D. Research director: Dr. David Strayer R&D expertise: Development and manufacture of nucleic acid pharmaceuticals for treatment of viral infections, immune system dysfunction and cancer. R&D collaboration: Hahnemann University, Temple University School of Medicine, National Institutes of Allergy and Infectious Diseases, Johns Hopkins University. Technological expertise: P/S, C/TC, PMC, CH/S, SY, Q, E, D-D, DD Main products/instrumentation under R&D: Ampligen(interferon) to treat HIV infection, chronic fatigue syndrome, see also AIDS/HIV, cancer, infectious diseases, chronic fatigue syndrome, Phase III/IV; Oragen, preclinical; Diagen research kit. Subsidiary bodies: Rockville, MD; Tavernier, FL.

1333 HEMOSOL, INC. Add: 2 Meridian Rd. Toronto, Ontario M9W 4Z7 Canada Tel: (416) 798-0700

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1334 HENDERSON MORLEY, LTD.

E-mail: [email protected] President/CEO: John Kennedy

Add: Metropolitan House 2 Salisbury Rd. Moseley B 13 8JS UK

Research director: David N. Bell

Tel: (44) 121-442-4600

R&D expertise: Research, development, manufacture and successful commercialization of Hemolink, a hemoglobin based oxygen carrier (HBOC) commonly termed a blood substitute, and other technologies derived from human hemoglobin; Cell therapy technology applications for cancer, autoimmune disease and HIV/AIDS.

Fax: (44) 121-442-4611

R&D collaboration: Fresenius A.G., Germany for Hemolink.

Principal products/instrumentation: Contract research/clinical trial products, natural products, nutraceuticals, vaccines, antiviral food supplements.

Web site: www.hemosol.com

Key sales market contracts: Fresenius for Hemolink. Technological expertise: P/S, BS, C/TC Main products/instrumentation under R&D: Cell therapy technology for cancer, autoimmune disease and HIV/AIDS, organ transplants/culture products, HemoLink: (Human based oxygen carrier (HBOC)) — Completed Phase II Canadian orthopedic trial, currently involved in four Phase II safety and efficacy trials in Canada, the U.S. and the UK, the trials cover hip and knee replacement, coronary artery bypass surgery and chronic anemia in renal dialysis patients; Red Cell Expansion: Currently involved in Phase II trials; HML-109: (Novel HBOC) — currently in early preclinical stage development; HML103: (Drug delivery) — currently in research stage development. Sealed and granted patents: Hemolink; Plus 67 patents worldwide, 11 of which are held in the U.S., an additional 129 are pending; Hemoglobinpolysaccharide conjugates, 6,500,930, U.S.; Methods for the production of TCR-gamma delta T cells, 6,537,812, U.S.; Efficient culture of stem cells for the production of hemoglobin, 6,361,998, U.S.

E-mail: [email protected] Web site: www.henderson-morley.com President/CEO: Mr. Andrew Knight R&D expertise: Development and manufacture of viruses and vaccines. Technological expertise: CB, C/TC, D-D

Main products/instrumentation under R&D: Antiviral polysaccharides, virus transport, virus antigen, bacterial diagnostics, viral attachment proteins, virogene.

1335 HEPAVEC AG FOR GENE THERAPY Add: Robert-Rossle-Strasse 10 Berlin 13125 Germany Tel: (49) 30-9489-2272 Fax: (49) 30-9489-2913 E-mail: [email protected] Web site: www.hepavec.com CEO: Herbert Stadler, Ph.D. Research director: C. Hofmann, Ph.D. R&D expertise: Research of liver gene therapy, liver tissue engineering products, related products development. R&D collaboration: MondoGen GmbH, DeveloGen AG, University Hospitals of Berlin, Heidelberg, Hannover, Stanford University, Karolinska Institutet, Sweden.

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Key license and trade contracts: Max Planck Society, Germany; Hospital for Sick Children, Toronto, Canada; CSIRO, Australia. Technological expertise: TE, C/TC, GT, RD Main products/instrumentation under R&D: Viral vectors for gene therapy, (animal adenoviral vectors, baculovirus-vectors), recombinant pl6/p53 viral vector for treatment of liver cancer, human liver cell lines for use in extracorporal liver support systems, preclinical and Phase I. Sealed and granted patents: Baculovirus as vector for gene therapy, pl6/p53 double expression strategy for the treatment of cancer, strategy for immortalization of hepatocytes, exclusive rights on the Wilson’s disease gene.

1336 HERBAMED, LTD. Add: Science-Based Industrial Park Kiryat Weizmann Rehovot 76326 Israel Tel: (972) 8-409648/9 Fax: (972) 8-407460 President/CEO: Dr. E. Katz R&D expertise: Development and manufacture of medicinal plants and natural treatments for prostate, cholesterol, muscular atrophy and aging-related diseases. Technological expertise: G, GT, BI Principal products/instrumentation: Contract development products, vaccines, reagents, antibodies. Main products/instrumentation under R&D: Natural medicinal plants for treatment of prostate, cholesterol, muscular atrophy and aging-related diseases.

Fax: (402) 398-0455 E-mail: [email protected] President/CEO: Larry J. Smith, Ph.D. Research director: Larry J. Smith, Ph.D. R&D expertise: Development and manufacture of antisense oligonucleotide therapeutics, catalytic antibody therapeutics. R&D collaboration: DeBio Pharm S.A., Lausanne, Switzerland, Oligo targeting P53 for cancer treatment; catalytic antibody therapeutics group, University of Texas, Houston School of Medicine. Key license and trade contracts: University of Nebraska Medical Center, University of Texas and University of Arizona. Technological expertise: E, P/S, AB, C/TC, CH/S, H/CF, PIS Main products/instrumentation under R&D: Anticancer oligo targeting P53 and P53 antisense oligos for cancer, Phase II; vaccines, catalytic antibody to treat AIDS, preclinical; catalytic antibody for cancer, preclinical. Sealed and granted patents: P53 antisense oligos for cancer — catalytic antibodies to cleave peptide bonds for use as therapeutics.

1338 HESKA CORPORATION Add: 1613 Prospect Pkwy. Ft. Collins, CO 80525 Tel: (970) 493-7272 Fax: (970) 493-7333 E-mail: [email protected] Web site: www.heska.com President/CEO: Fred M. Schwarzer Research director: Robert B. Grieve, Ph.D.

1337 HESED BIOMED, INC. Add: 7824 Jackson St. Omaha, NE 68114

R&D expertise: Development, manufacturing and marketing of animal health products for dogs, cats and horses.

Tel: (402) 398-0230

Joint ventures: Novartis, Bayer, Eisai.

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Key license and trade contracts: 3-Dimensional Pharmaceuticals, Virus Research Institute, University of California, Harvard University. Technological expertise: Q, RD, C/TC, P/S Principal products/instrumentation: Heartworm diagnostics, periodontal disease therapeutics, allergy diagnostics, vaccines. Main products/instrumentation under R&D: Animal health products for dogs, cats and horses. Subsidiary bodies: Des Moines, Iowa; Port Washington, NY; Waukesha, WI; Teignmouth, England; Fribour, Switzerland.

1339 HETO-HOLTEN A/S Add: Gydevang 17-19 Allerod DK-3450 Denmark Tel: (45) 48-16-6200 Fax: (45) 48-16-6297

E-mail: [email protected] Web site: www.hettichlab.com President/CEO: G. Eberle R&D expertise: Development, manufacture and distribution of laboratory centrifuges and other biomedical equipment. Key sales market contracts: Representatives and dealers in numerous countries all over the world. Technological expertise: P/S, R, BME Principal products/instrumentation: Hettich centrifuges. Main products/instrumentation under R&D: Centrifuges, centrifuge tube, centrifuge rotor, centrifugal ultrafilter, centrifugal extractor. Sealed and granted patents: Several Hettich products are patented.

1341 HIGH-Q, INC.

President/CEO: Jan Boger

Add: Wilmette, IL 60091

Research director: Finn Olsen and Erik Traeholt

Tel: (800) 474-2674

R&D expertise: Development and manufacture of laboratory biomedical equipment.

E-mail: [email protected]

Technological expertise: BME Principal products/instrumentation: Contract research/clinical trials products, safety cabinets, freeze dryers. Main products/instrumentation under R&D: Laboratory-scale purification devices, laboratory drug information management systems, labwares, biotech wares.

1340 HETTICH-ZENTRIFUGEN Add: GMBH & CO. KG Gartenstr. 100 Tuttlingen D-78532 Germany Tel: (49) 0 7461-7050 Fax: (49) 0 7461-705125

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Fax: (800) 474-2672 Web site: www.high-q.com President: Erich L. Gibbs, Ph.D. Research director: Erich. L. Gibbs, Ph.D. R&D expertise: Development and manufacture of laboratory instruments (water purification) and labwares. Technological expertise: BA, C/TC, COC, GA, PB, PIS Principal products/instrumentation: Organ transplants/culture, reagents, High-Q 103S glass lab stills, High-Q 103C container modules, High-Q 103CC container carriers, High-Q 103 ROPT reverse osmosis. Main products/instrumentation under R&D: Water purification tower, water purification treatment devices, lawares, biotech wares.

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1342 HISAMITSU PHARMACEUTICAL CO. INC.

1344 HITACHI INSTRUMENTS, INC. Add: 3100 North First St. San Jose, CA 95134

Add: 2732 Loker Av. West Carlsbad, CA 92008 Tel: (760) 431-4670 Fax: (760) 431-4679 E-mail: [email protected] R&D expertise: R&D of peptides. Technological expertise: RD, AB, C/TC, GT Main products/instrumentation under R&D: Peptide agents, peptide nucleic acid, peptinogen, peptide derivate. Sealed and granted patents: Peptides derived from the heparin binding domain of fibronectin, 6,274,704, U.S.

1343 HITACHI GENETIC SYSTEMS

Tel: (408) 432-0520 Fax: (408) 432-0704 E-mail: [email protected] Web site: www.hii-hitachi.com President/CEO: Mark McDonald Research director: Yoshi Nomura R&D expertise: Development and manufacture of analytical instruments. Key sales market contracts: William D. Synder. Technological expertise: P/S, COC, CH/S, HTDS Principal products/instrumentation: Liquid chromatography, fluorescence, mass spectrometry GC/MS, and UV/Vis spectrophotometers; LC/MS, FL spectrophotometers.

Add: 601 Gateway Blvd., Suite 500 S. San Francisco, CA 94080

Main products/instrumentation under R&D: Fluorescent image analyzer.

Tel: (800) 624-6176

Sealed and granted patents: #5,323,110 Technique for compensating for patient motion in magnetic resonance imaging.

Fax: (650) 615-7699 E-mail: [email protected] Web site: www.hitachi-soft.com/gs President/CEO: Satoshi Sakashita Research director: Sheila Colby, Ph.D. Subsidiary of Hitachi Software Engineering Co. Ltd. R&D expertise: R&D of laboratory equipment and instrumentation. Technological expertise: P/S, Q, BI, CH/S, HTDS, BME

1345 HKIB/TECHPOOL RESEARCH LAB, LTD. Add: 2 Biotechnology Ave. 12 Miles, Tai Po Road Shatin, N.T. Hong Kong Tel: (852) 2603-5111 Fax: (852) 2603-5012 President/CEO: Dr. Albert Y. Chang

Principal products/instrumentation: FMBIO II, Fluorescent image analyzer, Sequence analysis software.

R&D expertise: Development and manufacture of human urine derived product.

Main products/instrumentation under R&D: Safety cabinets, freeze dryers, labwares, biotech wares.

Main products/instrumentation under R&D: Human urine derived products, human urine derived protein.

Technological expertise: P/S

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1346 HONG KONG INSTITUTE OF BIOTECHNOLOGY LIMITED Add: 2 Biotechnology Av. 12 Miles, Tai Po Road Shatin, N.T. Hong Kong

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Principal products/instrumentation: Natural products, organ transplants/culture, biologicals, pharmaceuticals, reagents, toxic waste processing, vaccines, glassware washers (Heinicke), incubators, ovens, sterilizers.

Tel: (852) 2603-5111 Fax: (852) 2603-5012 E-mail: [email protected] Web site: www.hkib.org.hk President/CEO: Shawn Leung Research director: Karen Fung R&D expertise: Development and manufacture of biopharmaceuticals, traditional Chinese medicine, clinical trial monitoring and consultation services. R&D collaboration: WHO/NTH — antimalaria vaccine. Technological expertise: F, RD, BA, C/TC, P/S Main products/instrumentation under R&D: Contract manufacturing, contract research/clinical trial products, pharmaceuticals, vaccines, traditional Chinese medicinal materials, clinical trial monitors.

1347 HOTPACK (SP INDUSTRIES COMPANY) Add: 10940 Dutton Road Philadelphia, PA 19154 Tel: (215) 824-1700

1348 HOUSTON BIOTECHNOLOGY, INC. Add: Armandale, NJ 08801-0953 Tel: (713) 363-0999 Fax: (713) 363-3715 President/CEO: J. Russell Denson Research director: Peter J. Kelleher, Ph.D. R&D expertise: R&D of biopharmaceutical products to prevent or treat ophthalmic diseases and disorders, related products manufacture. Key sales market contracts: Santen Pharmaceuticals — secondary cataract product. Key license and trade contracts: Baylor Coll. of Medicine — secondary cataract product. Technological expertise: C/TC, RD, P/S, GA, H/CF Main products/instrumentation under R&D: Immunotoxin — secondary cataract product, Phase III; Immunoconjugate to treat glaucoma, research; ophthalmic cream, ophthalmic ointment.

1349 HUBER

Fax: (215) 637-0519 E-mail: [email protected] Web site: www.hotpack.com President/CEO: Jay Silverman R&D expertise: Research of pharmaceutical, biopharmaceutical and life science, products development. Technological expertise: BME, F, PIS, PG

Add: Werner-Von-Siemens-Strasse Offenburg D-77656 Germany Tel: (49) 781-96030 Fax: (49) 781-57211 E-mail: [email protected] Web site: www.huber-online.com President/CEO: Daniel Huber

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R&D expertise: Development and manufacture of cooling and heating products.

Fax: (215) 672-7807

Technological expertise: F, COC, PMC

Web site: www.hullcompany.com

Principal products/instrumentation: Contract manufacturing products, cryogenic chillers, bath circulators, calibration baths, chillers.

President/CEO: Lewis W. Hull

Main products/instrumentation under R&D: Cooling and heating circulators.

E-mail: Huilcorp.com

Research director: John Fay R&D expertise: Machinery manufacturing of pharmaceutical industries. Key license and trade contracts: Hisaka, Japan.

1350 HUDSON CONTROL GROUP, INC. Add: 44 Commerce Street Springfield, NJ 07081 Tel: (973) 376-7400 Fax: (973) 376-8265 Web site: www.hudsoncontrol.com President/CEO: Philip Farrelly Research director: Dr. Cliff Olson, Chief Scientific Officer R&D expertise: Automation devices development and production. Key sales market contracts: Apricot Designs, Inc. Monrovia, CA. 96,384,1536 well pipetting systems.

Technological expertise: CH/S, PMC, BM Principal products/instrumentation: Contract manufacturing products, lab and pilot freeze dryers, production freeze dryers for pharmaceutical and related industries. Plastics molding machinery and accessories, continuous emissions monitoring systems, mechanical vacuum pumps. Main products/instrumentation under R&D: Novel freeze drying machinery for lab and pilot research. Sealed and granted patents: Eight relating to freeze drying machinery.

1352 HUMAGEN FERTILITY DIAGNOSTICS, INC.

Technological expertise: BME Principal products/instrumentation: PlateCrane, Plate Silo, AutoReact T minibio reactor system for high throughput cell culturing and fermentation testing, automated colony picker. Main products/instrumentation under R&D: Automated sample injector, automatic pipettor, proprietory software. Sealed and granted patents: Proprietory software.

Add: 2400 Hunter’s Way Charlottesville, VA 22911 Tel: (804) 979-4000 Fax: (804) 295-5912 Web site: www.humagenivf.com President/CEO: Debra Bryant, Ph.D. R&D expertise: Development of IVF products, manufacture of micropipettes. Joint ventures: Biochem Immnunosystems. Technological expertise: BME

1351 HULL COMPANY Add: 3535 Davisville Rd. Hatboro, PA 19040 Tel: (215) 672-7800

Principal products/instrumentation: Micropipettes and semen analysis kits. Main products/instrumentation under R&D: In vitro fertilization products.

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1353 HUMAN BIOLOGICS INTERNATIONAL Add: 7150 E. Camelback Rd. Suite 245 Scottsdale, AZ 85251 Tel: (480) 990-2005 Fax: (480) 990-2155 E-mail: [email protected] Web site: www.humanbiologics.com President/CEO: Dom C. Cook Research director: Nigel Brown R&D expertise: Bioprocess engineering products; cell and tissue culture; well-characterized human liver biomaterials and molecular products to ascertain preclinical drug interactions in man. Joint ventures: Phoenix International Life Sciences. R&D collaboration: Phoenix International Life Sciences. Technological expertise: E, PMC, P/S, C/TC Principal products/instrumentation: Enzymes, plasma proteins, HepatoSomes human liver microsomes, HepatoSNine human liver S9 fractions, HepatoSytes, HepatoSol, CYPKits, HepatoPools, innovative GLP products designed to identify the P450 enzyme(s) responsible for metabolizing drugs, new specialty HepatoPools and CYPKits offer solutions to confirm the data obtained with the patented HepatoScreen test kit, unique software (HepatoSoft), inhibitory antibodies to various human P450 enzymes. Main products/instrumentation under R&D: Several monoclonal antibodies to individual liver P450 isozymes; enzyme expression systems, cytochrome P450. Subsidiary bodies: Joint venture with Phoenix International Life Sciences, Inc.; Joint venture with MDS Pharma Services. Sealed and granted patents: U.S. Patent 5,478,723 — a method and apparatus for determining the role of cytochrome P450 and

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related enzymes in the metabolism of drugs and other chemicals.

1354 HUMAN GENOME SCIENCES Add: 9410 Key West Ave Rockville, MD 20850 Tel: (301) 309-8504 Fax: (301) 309-8512 Web site: www.hgsi.com President/CEO: William A. Haseltine, Ph.D. Research director: Craig Rosen, Ph.D. R&D expertise: Gene identification, isolation and characterization for the purpose of discovery of therapeutic compounds and diagnostics, biotechnology medicines and vaccines development and production. R&D collaboration: SmithKline Beecham, Genentech, Inc. Key sales market contracts: SmithKline Beecham Technological expertise: RD, F, P/S, GA, R, H/CF, C/TC, CH/S, SY, GT, COC, Q, AB, BS Principal products/instrumentation: Biologicals, vaccines, reagents, antibodies, cytokines. Main products/instrumentation under R&D: Myeloid progenitor inhibitory factor-1, for chemoprotection, Phase II–III; repifermin (keratinocyte growth factor-2), for treatment of wound healing, Phase II–III; mucositis, Phase III; human neuropeptide receptor, preclinical; human neuropeptide receptor; 76-week results of Phase III trials of BENLYSTA™ in systemic Lupus Erythematosus, 2010. Sealed and granted patents: S2 human secreted proteins, 20070248593, U.S.; Galectin II, 20080015149, U.S.; human neuropeptide receptor, 20080027020, U.S.; 98 human secreted proteins, 20080051338, U.S.; secreted protein HEMAE80, 6,914,047, U.S.; human glycosylation enzymes, 6,858,415, U.S.; enterococcus faecalis polynucleotides encoding EF059, 6,913,907, U.S.; albumin fusion proteins, 6,946,134, U.S.; chemokine alpha 3,

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6,908,986, U.S.; antibodies to growth factor HTTER36, 6,884,594, U.S.; secreted protein HRGDF73, 7,053,190, U.S.; tumor necrosis factor receptor-5, 7,049,402, U.S.; streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines, 7,056,510, U.S.; albumin fusion proteins, 6,994,857, U.S.; interleukin-19 antibodies, 7,056,681, U.S.; chemokine alpha-7 variants, 7,001,595, U.S.; antibody which binds human blue-light photoreceptor hCRY2, 6,929,921, U.S.; antibodies to secreted protein HEMCM42, 7,001,992, U.S.; human stanniocalcin-alpha, 6,995,885, U.S.; antibodies against human protein HUVDJ43, 6,953,667, U.S.; follistation-3, 6,953,662, U.S.; secreted protein HCE3C63, 6,936,691, U.S.; secreted protein HHTLF25, 6,924,354, U.S.; natural killer cell activating factor II, 7,078,482, U.S.; antibodies to chemokine α-4, 6,921,645, U.S.; cytokine receptor common gamma chain like, 6,979,443, U.S.; follistatin3, 6,921,644, U.S.; chemokine α-6, 6,982,320, U.S.; antibodies to protein HPMBQ91, 6,919,433, U.S.; vanilloid receptor-2, 6,906,178, U.S.; antibodies to human tumor necrosis factor receptor TR9, 6,919,078, U.S.; albumin fusion proteins, 6,905,688, U.S.; tissue factor pathway inhibitor-3, 6,916,629, U.S.; death domain containing receptor 4, 6,902,910, U.S.; interleukin-1B converting enzyme like apoptotic protease-6, 6,890,721, U.S.; human endokine alpha, 7,078,027, U.S.; antisense modulation of polo-like kinase expression, 6,906,186, U.S.; human G-protein coupled receptors, 6,887,683, U.S.; streptococcus pneumoniae SP036 polynucleotides, 6,887,663, U.S.; human tumor necrosis factor receptor, 7,094,564, U.S.; modified shine-dalgarno sequences and methods of use thereof, 7,094,573, U.S.; antibodies to human chemokine beta-9, 7,097,985, U.S.; tumor necrosis factor-gamma, 6,824,767, U.S.; human tissue inhibitor of metalloproteinase-4, 6,828,424, U.S.; staphylococcus aureus genes and polypeptides, 6,821,754, U.S.; metalloproteinases, 6,878,812, U.S.; human protein HFXJW48, 6,881,823, U.S.;

methods of treatment of immune system related disorders using Neutrokine-alpha, 6,881,401, U.S.; human secreted protein HTEEB42, 6,878,806, U.S.; protein HMAAD57, 6,878,687, U.S.; antibodies against secreted protein HTEBYII, 6,951,924, U.S.; human tumor necrosis factor receptors TR13 and TR14, 6,951,738, U.S.; death domain containing receptors, 6,951,735, U.S.; human tumor necrosis factor receptors TR9, 6,949,358, U.S.; staphylococcus aureus polynucleotides and sequences, 6,737,248, U.S.; lysyl-oxidase HOHEC84 polynucleotides, 6,743,613, U.S.; methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5), 6,743,594, U.S.; death domain containing receptor 5, 6,743,625, U.S.; colon-specific gene and protein, 7,132,509, U.S.; chemokine beta-15, 7,135,551, U.S.; antibodies that immunospecifically bind BLyS, 7,138,501, U.S.; vascular endothelial growth factor 2 and methods of use, 7,153,827, U.S.; vascular endothelial growth factor 2, 7,153,942, U.S.; secreted protein HHTLF25 antibodies, 7,105,644, U.S.; antibodies that specifically bind to GMAD, 7,109,302, U.S.; antibodies to human vascular endothelial growth factor 2, 7,109,308, U.S.; antibodies to human tumor necrosis factor receptor-like genes, 7,078,493, U.S.; apoptosis related polynucleotides, polypeptides, and antibodies, 7,078,186, U.S.; extracellular/epidermal growth factor-like protein, 6,852,506, U.S.; antibody to an IL-17 receptor like protein, 6,849,719, U.S.

1355 HUNTINGDON LIFE SCIENCES Add: P.O. Box 2360 Mettlers Road East Millstone, NJ 08875 Tel: (732) 873-2550 Fax: (732) 873-8513 Web site: www.huntingdon.com President/CEO: Alan Staple Research director: Dr. Sylvie Gosselin

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R&D expertise: Toxicology testing research, related products manufacture.

Technological expertise: T, GA, P/S, RD, G, PIS, SY, E, F

Technological expertise: COS, ET

Principal products/instrumentation: Restriction enzymes, restriction endonuclease, nucleic acid isolation.

Main products/instrumentation under R&D: In vitro toxicology testing, contract research/ clinical trial products, biologicals, toxic cyclic peptide, toxicosozin.

1356 HUNTINGDON LIFE SCIENCES, LTD. Add: Woolley Rd. Huntingdon, bridgeshire PE18 6ES UK

Cam-

Tel: (44) 14-808-9043

Main products/instrumentation under R&D: Reagents for molecular biology research.

1358 HYBAID, LTD. Add: Action Court Ashford Road Ashford, Middlesex TWl5 1XB UK Tel: (44) 178-442-5000

Fax: (44) 14-808-91685

Fax: (44) 178-424-8085

President/CEO: Christopher Cliffe

E-mail: [email protected]

R&D expertise: R&D of contract items (nonclinical safety testing).

Web site: www.hybaid.com

Key sales market contracts: AEA Technology.

Research director: Mark Ebdon

Main products/instrumentation under R&D: Vaccines, contract research/clinical trial products, in vitro toxicology testing method, nonclinical safety testing.

Subsidiary of Thermo Bioanalysis

1357 HYBAID GMBH Add: Rischerstrasse 12 Heidelberg D-69123 Germany Tel: (49) 62-2182-8010 Fax: (49) 62-2184-0610 E-mail: [email protected] Web site: www.hybaid.de President/CEO: Hans-Joachim Muller

President/CEO: Brian Wilkinson

R&D expertise: Development and manufacturer of molecular biology equipment and reagents. Technological expertise: Q, P/S, GA, PB, G, BME Principal products/instrumentation: DASH — SNP Scoring; MuitiBlock system-flexible networked PCR; PCR expressor; electrophonesis; hybridisation equipment; nucleic acid purification; automated DNA extraction; restriction enzymes; customixed oligos, peptides and gene synthesis and biochips. Main products/instrumentation under R&D: Molecular biology new equipment.

Research director: Alexandria Schambony, Ph.D. Subsidiary of Hybrid Ltd., U.K. Joint ventures: Interactiva/Lab Systems. R&D expertise: R&D of restriction enzymes, nucleic acid isolation, reagents, and related products manufacture.

1359 HYBRIDON, INC. Add: 155 Fortune Blvd. Milford, MA 01757 Web site: www.hybridon.com President/CEO: E. Andrews Grinstead, III

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R&D expertise: Development and manufacture of therapeutic pharmaceutical products using antisense technology, manufacturing of oligonucleotides to third parties.

Europe, Canada), recombinant DNA platform technology; related products manufacture.

Joint ventures: Symbiotech, Inc. MethylGene, Inc.

R&D collaboration: Searle, Canada.

R&D collaboration: Hoffmann-La Roche, Ltd., GD Searle & Co, Medtronic, Inc. Key sales market contracts: Perkin-Elmer Technological expertise: Q, AB, COC, D-D, P/S, SY Main products/instrumentation under R&D: Contract manufacturing products, in vitro toxicology testing method. GEM91to treat AIDS, Phase IIb/III; GEM 132 for CMV Systemic; GEM 92 (antisense) to treat HIV injection/ AIDS, Phase II; GEM 231 (antisense) for treatment of solid tumors (monotherapy and in combination with taxanes), Phase II/III. Sealed and granted patents: Immunostimulatory oligonucleotide multimers, 20070179103, U.S.; HPV-specific oligonucleotides, 6,458,949, U.S.; oligonucleotides specific for hepatitis B virus, 6,984,729, U.S.; method of down-regulating gene expression, 6,936,593, U.S.; base protecting groups and synthons for oligonucleotide synthesis, 6,531,589, U.S.; MDM2-specific antisense oligonucleotides, 6,946,447, U.S.

Joint ventures: Protein Specialties, Inc. Guelph, ON, Canada. Technological expertise: E, PA, RD, C/TC, D-D, H/CF, P/S Principal products/instrumentation: Contract R&D of monoclonal antibodies, protein immuno and bioassays, protein purification protocols. Main products/instrumentation under R&D: Long half-life chimeric version of IL-2, IL-6, and other cytokines, recombinant DNA platform technology. Sealed and granted patents: Half-life extension of biologically active proteins or peptide through the production of chimeric proteins (USA, Europe and Canada).

1361 HYCLONE LABORATORIES, INC. Add: 1725 So. HyClone Rd. Logan, UT 84321 Tel: (435) 753-4584 Fax: (435) 753-4539 E-mail: [email protected] Web site: www.hyclone.com President/CEO: Leland Foster, Ph.D. Research director: Richard Wilkinson

1360 HYBRISENS, LTD. Add: York University, Keele St. Campus Farquharson Bldg., Room 104 Toronto, ON M3J 1P3 Canada Tel: (416) 736-5504 Fax: (416) 736-5979 E-mail: [email protected] President: Dr. Ezekiel Y. Shami Research director: Ezekiel Y. Shami R&D expertise: R&D of half-life extension research of cytokines via patented (USA,

Subsidiary of Perstorp. R&D expertise: Development of cell and tissue culture, cell culture consumable products. Major partners: Imutec Corp. Technological expertise: LP, BA, C/TC, PMC, P/S Principal products/instrumentation: HyClone fetal bovine serum; other animal sera; HyQ cell culture media; bioprocess containers systems. Main products/instrumentation under R&D: Cell culture consumable products, culture devices.

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Subsidiary bodies: N.V. HyClone Europe S. A. Industriezone III, B-9320 Erembodegem — Aalst, Belgium, Tel: (32) 53-834404; Fax: (32) 53-83-7638

1362 HYCULT BIOTECHNOLOGY B.V. Add: Frontstraat 2a Uden 5405PB Netherlands

423

industries: biopharm, food, pulp/paper, chemicals, waste treatment. (Direct contact with steam injection heating.) Technological expertise: BME, CS Principal products/instrumentation: Hydroheater, Thermotech, Wizard Drum Tool. Main products/instrumentation under R&D: Direct contact steam injection heating.

Tel: (31) 413-25-1335 Fax: (31) 413-26-6605

1364 HY-LABS

E-mail: [email protected] Web site: www.hbt.nl President/CEO: W. H. de Niet Research director: E. Francot R&D expertise: Development and manufacture of new biotech products for endotoxin research.

Add: Science-Based Industrial Park Kiryat Weizmann Rehovot 76326 Israel Tel: (972) 8-406995 Fax: (972) 8-408155 President/CEO: Michael Steinberg

Joint ventures: Sanbio B.V. in The Netherlands.

Research director: Dr. Ruth Cohen

R&D collaboration: Several universities.

R&D expertise: Development and manufacture of bacteriological culture media and diagnostic kits for microbiology.

Key sales market contracts: Worldwide distributors. Technological expertise: PA, P/S, C/TC Main products/instrumentation under R&D: Contract manufacturing products, endotoxin antibodies and kits; TNF kits, endotoxin neutralizing protein, endotoxoid, other new biotech products.

1363 HYDRO-THERMAL CORPORATION Add: 400 Pilot Court Waukesha, WI 53188

Technological expertise: C/TC, DK, F Principal products/instrumentation: Hy-Giene Monitor — for identification of bacterial contamination and potential pathogens in food, dairy, cosmetic and pharmaceutical industries; Hy-Mastitis — for identification of subclinical mastitis in dairy industry; Hy-Enterotest — for determination of enteropathogenic bacterial. Main products/instrumentation under R&D: Bacteriological culture media, diagnostic kits for microbiology, diagnostic reagents for food poisoning.

Tel: (262) 548-8900 Fax: (262) 548-8908

1365 HYPERCUBE, INC.

E-mail: [email protected] Web site: www.hydro-thermal.com

Add: 1115NW 4th St. Gainesville, FL 32601

President/CEO: Gary Zaiser

Tel: (352) 371-7744

Research director: Brace Cincotta

Fax: (352) 371-3662

R&D expertise: Development and manufacture of heating applications in a myriad of

E-mail: [email protected] Web site: www.hyper.com

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President/CEO: Dr. Neil Ostlund R&D expertise: Development and manufacture of scientific software.

R&D expertise: Research and manufacture of biotechnology medicines.

Technological expertise: CH/S

Key sales market contracts: Stem Cell Technologies, Inc. Canada.

Principal products/instrumentation: HyperChem, HyperN-MR, HyperChemLite.

Technological expertise: C/TC, GA, HTDS, H/CF, PIS, P/S, RD, SY, SMC

Main products/instrumentation under R&D: Software for pharmaceutical development.

Main products/instrumentation under R&D: Biologicals, reagents, stem cell, cell/tissue culture products, cytokines, biotechnology medicines.

1366 HYPERSIL Add: 300 Second Ave. Needham Hts., MA 02494

1368 HYSEQ, INC.

Tel: (781) 453-2990

Add: 670 Almanor Ave. Sunnyvale, CA 94085

Fax: (781) 453-2992

Tel: (408) 524-8100

Web site: www.hypersil.com

Fax: (408) 524-8141

President/CEO: Dr. John Dolphin

E-mail: [email protected]

Research director: Paul Ross

Web site: www.hyseq.com

Subsidiary of Thermo Quest

President/CEO: George Rathmann

R&D expertise: Research and manufacture of HPLC columns and media.

Research director: Radoje T. Drmanac, Ph.D.

Technological expertise: CC, P/S, BA, COC

R&D expertise: Research and development of biopharmaceuticals.

Principal products/instrumentation: Hypersfl, Hypercarb, Hypersil BDS, Hypersil Elite, HYPurity Elite, capillary electro chromatography columns.

Joint ventures: Chiron Corp., Perkin-Elmer Corp.

Main products/instrumentation under R&D: HPLC-grade reagents, HPLC-grade solvent.

Technological expertise: Q, BI, GA, RD, R

Subsidiary bodies: Runcorn, UK

1367 HYSEL INDIA PVT, LTD. Add: 41-DDA Shopping Centre Sukhdev Vihar New Delhi 110 025 India Tel: (91) 11-684-6565 Fax: (91) 11-691-5917 E-mail: [email protected] President/CEO: V. S. Narayanan

R&D collaboration: Kiron Brewery, Ltd., University of California at San Francisco. Principal products/instrumentation: SBA Format 1A diagnostics. Main products/instrumentation under R&D: HyChip, biochip, biopharmaceuticals. Sealed and granted patents: 5,492,806; 5,202,231; 5,525,464; anti-interleukin-1 receptor antagonist antibodies and uses thereof, 6,294,655, U.S.; methods for sequencing repetitive sequences and for determining the order of sequence subfragments, 6,297,006, U.S.; interleukin-1 Hy2 materials and methods, 6,372,892, U.S.

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1369

IAN INTERNATIONAL AIDS NETWORK

Add: 189 Eagle Rt. Roseiand, NJ 07068 Tel: (973) 877-5481 Fax: (973) 877-2962 President/CEO: Peter Stewart Research director: R&D expertise: Research and product development of HIV and hepatitis C. Joint ventures: Medical networks to due medical research trials. Technological expertise: PA, AF, AB, BI Main products/instrumentation under R&D: Antivirals, Phase III, HIV-neutralizing antibodies, hepatitis C (rDNA) vaccine, hepatitis C virus vaccine.

1370

IBA GMBH (INSTITUT RUER BIOANALYTIK)

Add: Rudolf-Wissell-str. 28 Goettingen 37079 Germany Tel: (49) 551-506-7201 Fax: (49) 551-506-7281 E-mail: [email protected]

425

services: recombinant protein expression, purification, detection, and assay; oligonucleotide synthesis: RNA, modified building blocks, gene synthesis; process scale contract manufacturing of biomolecules under cGMP and non-cGMP; online general analyser for bioprocess control (OLGA); training in the life sciences; Fusion Cloning System: The StarGate® Fusion Cloning System allows the construction of artificial operons for multiple gene expression in bacterial or mammalian cells or the generation of fusion proteins. StarGate is a technology that enables the systematic combination of promoters (i.e., hosts), purification tags, or other genetic elements with any gene of interest (GOI) in a convenient cloning system. The new Fusion Cloning System provides an optional intermediate step in the established standard procedure, which then results in fusion proteins instead of single proteins. Three different versions of StarGate Fusion Cloning Sets are available to date, 2009. Main products/instrumentation under R&D: IRA Biologies GmbH, process scale contract manufacturing of bio molecules under cGMP or non-cGMP. Sealed and granted patents: Protein expression U.S. 5,849,576/Protein purification & detection U.S. 5,506,121 and a further pending application.

Web site: www.iba-go.de President/CEO: Herbert Stadler

1371

IBAH, INC.

Research director: Dr. Joachin Bertram R&D expertise: Research and manufacture of recombinant proteins/products and services (streptag), nucleic acids/DNA & RNA/products & services, bioprocess control (OLGA). Technological expertise: F, AB, BA, COC, PMC, P/S, RD, SY Principal products/instrumentation: Recombinant protein expression detection and purification, nucleic acid synthesis, esp. RNA; online general analyzer, products and custom

Add: 4 Valley Square 512 Township Line Rd. Blue Bell, PA 19422 Tel: (215) 283-0770 Fax: (215) 283-2726 Web site: www.ibah.com President/CEO: Geraldine A. Henwood Research director: G. Termini R&D expertise: Product development and manufacture services, including contract clinical

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research to the pharmaceutical and biotech industries.

1373

IBEX TECHNOLOGIES, INC.

Joint ventures: Drug delivery research services, BioPharm clinical services.

Add: 5485 PARE Montreal, Quebec H4P 1P7 Canada

R&D collaboration: Eli Lilly and Co.

Tel: (514) 344-4004

Contract unit of market sell: Whitehall Laboratories

Fax: (514) 344-8827

Key license and trade contracts: Smith Kline Beecham

Web site: www.ibexpharma.com

Technological expertise: DD, D-D Main products/instrumentation under R&D: Oral delivery of calcitonin — preclinicals; oral delivery of HGH — preclinicals; oral delivery of calcitriol.

E-mail: [email protected] President/CEO: Robert Heft Research director: Jan Horrow R&D expertise: Research, development and manufacture of enzymes for therapeutic applications such as cardiovascular disease, cancer, and disease of genetic orgin. Contract unit of market sell: Bauder, Medtronics.

1372

IBEX PHARMACEUTICALS, INC.

Add: Montreal, Quebec H4P 1P7 Canada Tel: (514) 344-4014 Fax: (514) 344-8837

Key license and trade contracts: McGill, M.I.T. Technological expertise: E, F, Q, SMC, C/TC, DD, D-D, P/S

R&D expertise: Development and manufacture of therapeutic enzymes products.

Main products/instrumentation under R&D: Neutralase for cardiac surgery, Phase III; Nutralase for treatment of angiolaplasty, Phase II; Extravase to treat ruperfusion injury, restenosis, chronic wounds etc., preclinical; Phenylase for treatment of phenyiketonuria, preclinical; heparinase I and III, preclinical.

Contract unit of market sell: Baxter, Medtronics, Haemoscope

Sealed and granted patents: Heparinase I for therapeutic and diagnostic use; Heparinase III.

Web site: www.ibex.ca President/CEO: Robert A. Heft, Ph.D. Research director: Paul Silver, Ph.D.

Technological expertise: P/S, RD Main products/instrumentation under R&D: Neutralase for heparin reversal — preclinical; IBT 9302 for reperfusion injury, restenosis and wound healing, Hep I for therapeutic and diagnostic application, therapeutic enzyme drug.

1374

IBRD-ROSTRUM GLOBAL, INC.

Add: 2525 Campus Dr. Irvine, CA 92715 Tel: (714) 476-2727 Fax: (714) 752-7295

Subsidiary bodies: 5 Great Valley Pkwy, Ste. 300, Malvern, PA 19355.

President/CEO: F. Richard Nichol, Ph.D.

Sealed and granted patents: Hep I for therapeutic and diagnostic use; Hep III.

R&D expertise: Full-service R&D of pharmaceutical and biotechnology medicines product

Research director: Sharon Anderson

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providing comprehensive drug development services. Technological expertise: C/TC, DD, D-D, E, ET Main products/instrumentation under R&D: Contract research/clinical trial products, biopharmaceuticals, vaccines, enzymes, antibodies, peptides. Subsidiary bodies: IBRD-Rostrum Global, Inc. Blue Bell, PA, U.S.A; ICCR (IBRD Center for Clinical Research), Neptune, NJ, U.S.A; IBRD Rostrum Ltd., Essex, U.K.; IBRD Japan, Tokyo, Japan.

1375

ICAGEN, INC.

Add: 4222 Emperor Blvd. Suite 460 Durham, NC 27723 Tel: (919) 941-5206

1376

427

ICCT TECHNOLOGIES R&D CENTER, INC.

Add: 3950 14th Av. Suite 307-308 Markham, ON L3R OA9 Canada Tel: (905) 479-1152 Fax: (905) 479-2258 E-mail: [email protected] Web site: www.iccttech.com President/CEO: Edward Cinits Research director: James Sun R&D expertise: Fuzzy-logic related product research, development and marketing. Technological expertise: C/TC Principal products/instrumentation: Biostretch systems. Main products/instrumentation under R&D: Cell and tissue culture, biotech medicines.

Fax: (919) 941-0813 E-mail: [email protected] Web site: www.icagen.com President/CEO: Dr. P. Kay Wagoner Research director: Doug Krafte

1377

ICN BIOMEDICALS, INC.

Add: 3300 Hyland Ave. Costa Mesa, CA 92626

R&D expertise: Drug research, discovery, design and development of novel therapeutics for ion channel targets; R&D biotechnology medicine products.

Tel: (714) 545-0100

Joint ventures: Eli Lilly & Co.

Web site: www.icnbiomed.com

R&D collaboration: Arqule, INC.

President/CEO: Adam Jemey

Key license and trade contracts: CalTech University, Northwestern University, Oregon Health Sciences University, University of Alabama, University of California, San Francisco.

Research director: Robert Beattie, VP, General Manager

Technological expertise: Q, SMC, AB, C/TC, COC, D-D, GA, HTDS, RD, R, CH/S Main products/instrumentation under R&D: Contract development products, novel therapeutics for ion channel.

Fax: (714) 641-7216 E-mail: [email protected]

Subsidiary of ICN Pharmaceuticals, Inc. R&D expertise: Development and manufacture of biotechnology research products, biochemical reagents, and clinical diagnostics, including diagnostic kits and reagents. providing dosimetry services. Contract unit of market sell: Fisher Scientific.

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Technological expertise: E, F, PA, C/TC, H/CF, PIS, P/S, RD, SY

Contract unit of market sell: Sciquest and Chemdex

Principal products/instrumentation: Biochemicals, immunochemicals, cell culture reagents, molecular biology reagents, neurochemicals, diagnostic kits and reagents, dosimeters and dosimetry services.

Technological expertise: P/S, COC, CH/S, AMS, FL

Main products/instrumentation under R&D: Biochemical reagents, clinical diagnostics.

1378

ICOGEN CORPORATION

Add: 454 North 34th St. Seattle, WA 98103

Principal products/instrumentation: Diode Array UV-VTS Spectrophotometers, Radio Chromatography Detectors, Mass Detector (Chromatography), Evaporative Light Scattering Detector. Main products/instrumentation under R&D: Laser-induced fluorescence, prototypes for microtite plates, Fiberoptic remote sensing and HPLC capillary electrophoresis, spectroscopy instruments.

Tel: (206) 545-2880 Fax: (206) 545-2983 E-mail: [email protected]

1380

ICOS CORP.

Web site: www.icogen.com

Add: 22021-20th Ave.SE Bothell.WA 98021

President/CEO: Frederick S. Hagen

Tel: (425) 485-1900

Research director: Frederick S. Hagen

Fax: (425) 489-0356

R&D expertise: Isolation research of human genes with therapeutic value; novel products development.

E-mail: [email protected]

Technological expertise: GA, E, Q, BI, C/TC, CH/S, P/S, RD Main products/instrumentation under R&D: Human genes with therapeutic value, human genome with therapeutic value.

1379

ICON SCIENTIFIC, INC.

Add: 12613 High Meadow Rd North Potomac, MD 20878 Tel: (301) 330-4266 Fax: (301) 990-9733 E-mail: [email protected] Web site: www.iconsci.com President/CEO: Terri Cohen R&D expertise: Reseach and development of chromatography, spectroscopy instrumentation and software, products manufacture.

Web site: www.icos.com President/CEO: Paul Clark Research director: W. Michael Gallatin, Ph.D. R&D expertise: Develop and manufacture of drugs for the treatment of serious diseases. Joint ventures: Suntory Ltd., Eli Lilly, Texas Biotech. Technological expertise: F, Q, E, PIS, GA, R, SMC, RD, P/S, H/CF, C/TC, PMC, CH/S, SY, HTDS Main products/instrumentation under R&D: Leukarrest (Hu23F2G) for treatment of ischemic stroke, Phase III~IV, 2008; IC351, Phase II; Pafase, Phase II; ICM3, Phase I/II; IC14 to treat severe sepsis, Phase II; IC351 (Cialis) global, Phase III; Sitaxsentan, Phase II; recombinant platelet activating factor acetylhydrolase (rPAF-AH) to treat respiratory distress syndrome and severe acute pancreatitis, Phase III, 2008; IL14 for treatment of severe sepsis, Phase I/II, 2008.

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Sealed and granted patents: 98 U.S. patents issued.

429

Research director: Dr. Robert Bryan R&D expertise: Development and manufacture of gene-based testing and subunit vaccines.

Tel: (64) 9-815-0624

R&D collaboration: Pasteur Merieux Connaught has licensed exclusive worldwide rights to TB subunit vaccine; University of Tennessee, GAS vaccine; University of British Columbia, E. coli 0157: H7.

Fax: (64) 9-815-0623

Technological expertise: GA, G, DK

E-mail: [email protected]

Main products/instrumentation under R&D: MRSA Detect Kit for external testing; VRE Detection Kit for preclinical testing; TB Detection Kit; Subunit Vaccine for TB-preclinical; Subunit Vaccine for Group A Strepococcus — preclinical; Subunit Vaccine for E. coli 0157: H7 R&D; StreptAvax group A streptococcus vaccine to treat diseases caused by group Astreptoccus, including necrotizing fasciitis, strepthroat, rheumatic fever.

1381

ICP, LTD.

Add: P.O. Box 6607 Auckland 1 New Zealand

Web site: www.icp.co.nz President/CEO: Dr. Rosemary Sharpin and Maxine Simmons Research director: Marine Simmons Contract unit of market sell: AgResearch, Ruakura and Wallaceville. R&D expertise: Development and manufacture of blood substitutes, antibodies and other biotech medicines. Technological expertise: P/S, BS, PA, AB Principal products/instrumentation: Ovagen follicle stimulating hormone; embryo transfer media; polyclonal antibodies; Confirmed — ELISA pregnancy test via milk for dairy cows; detection of colostrum in cow’s milk; Rapid Coliform Test for dairy industry, Low endotoxin bovine albumin. Main products/instrumentation under R&D: Blood substitutes, monoclonal/polyclonal antibodies, other new biotech medicines.

1382

ID BIOMEDICAL CORPORATION

Add: 1510 800 West Penden St. Vancouver, BC V6C 2V6 Canada

Subsidiary bodies: San Diego Office: 11588 Sorrento Valley Rd, Suite 16, San Diego, CA 92121, Tel: (619) 794-1919, Fax: (619) 7941922; Subsidiary: ID Vaccine Corp., 3445 Carillon Point, Kirkland, WA 98033, Tel: (206) 844-9001, Fax: (206) 844-9101. Sealed and granted patents: Scissile Linkage U.S.# 4,876,187, Oct 24/89; #5,011,769, April 30/91; July 7/92; Catalytic Hybridization System — Aust. #623642, Sept. 15/92; U.S. #5,403,711, Apr 4/95; Euro. # 365627, Dec 22/93

1383

IDBS

Add: 2 Occam Court Surrey Research Park Guildford, Surrey GU2 5QB U.K. Tel: (44) 1483-595-000

Tel: (604) 431-9314

Fax: (44) 1483-595-001

Fax: (604) 431-9378

E-mail: [email protected]

E-mail: [email protected]

Web site: www.idbs.co.uk

Web site: www.idbiomed.com

President/CEO: Neil Kipling

President/CEO: Frank A. Holler

Research director: Matt Botwood

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R&D expertise: Development and manufacture of software solutions for accelerating drug discovery. Joint ventures: CHEMOVATION (For Bespoke COMBI-CHEM Informatics Infrastructure). Contract unit of market sell: Spotfire, the automation partnership; Harvard Medical School, Arrow Therapeutics.

Sealed and granted patents: Patents in GI drugs.

1385

IDEA INNOVATIVE DERMAL APPLICATIONS GMBH

Add: Frankfurter Ring 193a Munich, Bavaria 80807 Germany

Key license and trade contracts: Afferent; CTC Laboratory Systems (distributes IDBS products in Japan).

Tel: (49) 89-324-6330

Technological expertise: SMC, BI, COC, CH/S, D-D, G, HTDS

President/CEO: Prof. Gregor Cevc

Principal products/instrumentation: ACTIVITYBASE, SARgen, Xlfit, AFFERENT, electronic laboratory notebook for research scientists of any discipline, data management. Main products/instrumentation under R&D: Software solution for accelerating drug discovery.

1384

IDDC CORPORATION

Add: Long Grove, IL 60047-9532 Tel: (847) 634-9586 Fax: (847) 634-3349 E-mail: [email protected]

Fax: (49) 89-324-1684 E-mail: TB80201 @sunrnail.lrz-muenchen.de Research director: Dr. K.J. Zuidam R&D expertise: Research, development and manufacture of new self-optimizing drug carriers, Transfersomes, for the non-invasive (Hausderucal/Hausuasal) drug delivery. R&D collaboration: Schering AG Technological expertise: DD Principal products/instrumentation: Transfersomes Main products/instrumentation under R&D: Corticosteroids (hydrocortisone/dexamethasone/ betamethasone/triamcinolone) Phase III; Insulin (Hausderuial), Phase IIa; influenza vaccine, Phase II; non-invasive drug delivery methods, new self-optimizing drug carriers.

Web site: www.IDDC-corp.com President/CEO: Esam Z. Dajani Research director: Esam Z. Dajani

1386

IDEC PHARMACEUTICALS CORP.

R&D expertise: Novel drug development services in preclinical and clinical research, regulatory affairs and pharmaceutical development.

Add: 11011 Torreyana Rd. San Diego, CA 92121

R&D collaboration: Major and start-up pharmaceutical and biotechnology companies.

Fax: (619) 550-8750

Technological expertise: DD, D-D Main products/instrumentation under R&D: Contract research/clinical trial products, GI drug.

Tel: (619) 550-8500 E-mail: [email protected] Web site: www.idecpharm.com President/CEO: William H. Rastetter, Ph.D. Research director: Nabil Hanna, Ph.D.

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R&D expertise: Development and manufacture of targeted immunotherapies for cancer and autoimmune diseases; other novel drugs research & development. Joint ventures: Mitsubishi Chemical Corp — primatized anti-B7 antibodies; Seikagaku Corp. — primatized anti-CD 23 antibodies; Eisai Co., Ltd. — humanized and primatized anti-gp39 antibodies. Contract unit of market sell: Genentech, INC. F. Hoffmann-LaRoche Ltd., Zenyaku Kogyo- IDEC-C2B8; SmithKIine Beecham — primatized anti-CD4 antibodies, including IDEC-CE9.1. Key license and trade contracts: SmithKline Beecham to develop and market Primatized anti-CD4 antibodies for autoimmune diseases. Mitsubishi Kasei Corp. to develop and market Primatized anti-B7 antibodies.

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and one granted European patent for IDECC2B8. IDEC also has 18 U.S. patent applications and numerous corresponding foreign applications; Induction of cytotoxic T-lymphocyte responses, 6,270,769, U.S.

1387

IDEXX CONTRACT RESEARCH SERVICES

Add: 2875 Kour Dr. West Sacramento, CA 95605 Tel: (800) 444-4210 Fax: (800) 372-2783 E-mail: [email protected] Web site: www.idexx.com President/CEO: Ms. Pat Panaia, W. Division Manager

Markets: Biologicals, pharmaceuticals

Research director: Ms. Poomima Kumar

Technological expertise: AB, PP, AT

Subsidiary of IDEXX Laboratories.

Principal products/instrumentation: Rituxan (Rituximae)

R&D expertise: Veterinary products, R&D services.

Main products/instrumentation under R&D: IDEC-Y2B8, for treatment of non-Hodgkin’s lymphoma, Phase III/IV; Clenoliximab/IDEC151 to treat rheumatoid arthritis, Phase II/III; IDEC-131/Mab gp39CD40L to treat systemic lupus erythematosus, Phase II/III; IDEC-Y2B8 with Rituxan rituximab to treat relapsed or refractory B-cell non-Hodgkin’s lymphoma; 9AC, cancer, Phase II; Anti-CD4, rheumatoid arthritis, Phase II; IDEC-131/Mab gp39CD40L for treatment of erythematosus, Phase II; Antigp39, immune system diseases, Phase I; AntiB7, autoimmune and inflammatory diseases, Preclinical; Anti-CD23, asthma & allergic rhinitis, Preclinical; Anti-MIF, immune system diseases, Preclinical.

Joint ventures: Blue Ridge Pharmaceuticals, Cardio Pet

Sealed and granted patents: IDEC holds one issued U.S. patent for PROVAX, the company’s antigen formulation. IDEC has one allowed U.S. patent for investment relations. The company’s primatized antibody technology

Fax: (207) 856-0346

Technological expertise: SMC, COC, CH/S, DD, D-D Principal products/instrumentation: contract research/clinical trial products, in vitro toxicology testing methods, veterinary diagnostic products — Vet Test; Vet Connect — Veterinary Software; Cardiopet, Radiopet.

1388

IDEXX LABORATORIES, INC.

Add: One Idexx Dr. Westbrook, ME 04092 Tel: (207) 856-0300 Web site: www.idexx.com President/CEO: David E. Shaw Research director: Erwin Workman, Ph.D.

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R&D expertise: Develop, manufacture and market of biotechnology medicines-based detection systems.

Principal products/instrumentation: Microbiology culture media, impedimetric microbiology instrumentation.

Technological expertise: Q, RD, C/TC, SY

Main products/instrumentation under R&D: Magnetic ceramic particle, compounds — chromogenic substrate.

Principal products/instrumentation: FlockCheck assays for poultry; Cite In-Clinic canine and feline testing; Cite Probe and SNAP In-Clinic canine and feline testing; VetTest 8008 In-Clinic Chemistry analyzer, livestock laboratory testing; food quality assurance testing; Coilert water test, immunoassay reagents, DNA probes, reagent systems. Sealed and granted patents: Identification of leucocytes bearing diagnostic marker for transmissible spongiform encephalopathies, 20080026364, U.S.; Apparatus and method for testing liquid samples, 20080003638, U.S.; Metal chelates and methods of using them for time-resolved fluorescence, 7,053,249, U.S.; Diagnosis of feline immunodeficiency virus infection using ENV/GAG polypeptide markers, 6,458,528, U.S.; Method and device for detecting analytes in fluids, 6,551,842, U.S.; Injectable compositions for the controlled delivery of pharmacologically active compound, 6,887,487, U.S.

Subsidiary bodies: IDG Research Ltd., Unit 1, Spring Likes Est., Deadbrook Lane, Aldershot, U.K., Tel: 01252 342204; Q Laboratories Ltd., Quayside,’ Navigation Way, Ashton on Ribble, Preston, U.K., Tel: 01772 722922; MDI, INC. 35888 Center Ridge Rd., North Ridgeville, OH, U.S.A., Tel: (213) 327-2585. Sealed and granted patents: CHE compounds — chromogenic substrates based on esculetins.

1390

IDM S.A.

Add: 172, Rue de Charonne Paris 75011 France Tel: (33) 140-090-411 Fax: (33) 140-090-425 E-mail: [email protected] President/CEO: Dr. Yves Fouron

1389

IDG (U.K.), LTD.

R&D expertise: Research of cellular therapy for cancer therapeutic program development.

Add: Topley House 52 Wash Lane Bury, Lancashire BL9 6AU U.K.

R&D collaboration: Medarex, Sanofi-Synthelabo.

Tel: (44) 161-797-5729

Technological expertise: GT, C/TC

Fax: (44) 161-762-9322

Main products/instrumentation under R&D: Mak Therapy, Phase II/III; Dendritophage Therapy, Phase I/II.

E-mail: [email protected] Web site: www.idgplc.com President/CEO: Colin Goodwille Research director: C.J. Stanley, Ph.D. R&D expertise: Research of biosciences — microbiology/immunology and related products manufacture. R&D collaboration: Foss Electric. Denmark Technological expertise: E, PA, CB

Sealed and granted patents: 16 patents issued in cellular therapy.

1391

IEC LABSYSTEMS

Add: 300 Second Ave. Needham Heights, MA 02494

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Tel: (781) 449-8060 Fax: (781) 444-6743 CEO: Lewis Rosenblum

433

Main products/instrumentation under R&D: Phase I: Pulmonary function; Phase I: Drug delivery; Phase I: Patient monitoring and compliance.

Subsidiary of Thermo Instruments R&D expertise: Development and manufacture of biomedical laboratory equipment and labwares. Technological expertise: Q, C/TC, GA Principal products/instrumentation: Finnpipette multichannel pipettes, Finnpipette single channel pipettes, including Finnpipette techpette, Finnpipette ACL (autoclavable pipettor), Finnpipette EZ biocontrol, Finnpipette multichannel techpette and the Finnpipette vacupette, centrifuges, including benchtop and floor models. Main products/instrumentation under R&D: Laboratory scale-up purification devices, labwares, biotechwares.

1392

IEP PHARMACEUTICAL DEVICES, INC.

Add: 6320 Angus Dr. Raleigh, NC 27613

1393

IGENE BIOTECHNOLOGY, INC.

Add: 9110 Red Branch Rd. Columbia, MD 21045-2024 Tel: (410) 997-2599 Fax: (410) 730-0540 E-mail: [email protected] Web site: www.igene.com President/CEO: Stephen E Hiu, Ph.D. Research director: Stephen F. Hiu, Ph.D. R&D expertise: Fermentation research, products design, development and scaleup. Technological expertise: F, BA, P/S Principal products/instrumentation: ClandoSan 618: EPA-approved, natural chitinbased nematicide, AstaXin: dried yeast source of natural astaxanthin, a pigment for salmon trout and prawns.

Tel: (919) 787-8666 Fax: (919) 787-5432 E-mail: [email protected] Web site: www.iepgroup.com

1394

IGEN INTERNATIONAL, INC.

President/CEO: Fred Sexton

Add: 16020 Industrial Dr. Gaithersburg, MD 20877

Research director: Perry Genova

Tel: (301) 984-8000

R&D expertise: Research, design, development, manufacture and distribution of proprietary medical instruments, drug diversion prevention, drug delivery and patient compliance systems.

Fax: (301) 208-3798

Technological expertise: BA, CH/S, DD, GA, PMC, P/S, R Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, pulmonary-respirator devices.

Web site: www.igen.com President/CEO: Richard J. Massey Research director: Renee Sugasawara R&D expertise: Development and manufacture of medical diagnostic products. Key license and trade contracts: Boehringer Mannheim Corp., Organon Teknika, Eisai. Technological expertise: C/TC, GM

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Principal products/instrumentation: ORIGEN detection systems & reagents, ORIGEN B&T cell growth factor, ORIGEN T-cell growth supplement. Sealed and granted patents: Elearo Aemfluminescence detection technology and process.

Main products/instrumentation under R&D: Contract manufacture pharmaceuticals, natural products, Anhydrovinblastine(AVLB), Phase II/III, non small cell lung cancer; CNS therapeutics targeting metabolic glutamate receptors (mGluRs). Sealed and granted patents: U.S. Patent, U.S. 6,011,041 issued.

1395

IGEPHARMA

Add: Biopole Clermont Limage Rond point du Biopole Saint Beauzire F-63360 France Tel: (33) 473-644-340 Fax: (33) 473-644-344 President/CEO: D. Paulet R&D expertise: R&D and scale-up production of drugs, cosmetics, veterinary products. Joint ventures: IGEPHARMA, a member of an association of economic interests of biotechnology companies, OCTOTECH GIE, which are set up in a science parc (a technopole): the BIOPOLE Clermont-Limagne.

1397

IIT RESEARCH INSTITUTE

Add: 10W. 35th St. Chicago, IL 60616 Tel: (312) 567-4859 Fax: (312) 567-4021 E-mail: [email protected] Web site: www.iitri.org/lifescience President/CEO: John B. Scott Research director: Dr. David L. McCormick

Technological expertise: D-D, DD

R&D expertise: Scientific research and development in all of the physical and biological sciences and related technologies.novel products manufacture.

Principal products/instrumentation: Cosmetics, pharmaceuticals, veterinary products.

Technological expertise: RD, C/TC, D-D, DD, BME

1396

IGT PHARMA, INC.

Add: 311-2386 East Mall Vancouver, BC V6T 1Z3 Canada Tel: (604) 822-3503

Principal products/instrumentation: R&D testing equipment and research other instrumentation.

1398

IKA WORKS, INC.

Fax: (604) 822-3506

Add: 2635 North Chase Pkwy SE Wilmington, NC 28405

E-mail: [email protected]

Tel: (910) 452-7059

Web site: www.igtpharma.com

Fax: (910) 452-7693

President/CEO: Bruce Schmidt

E-mail: [email protected]

Research director: Ken Curry

Web site: www.ika.net

R&D expertise: Development and manufacture of anticancer and CNS therapeutics.

President/CEO: Rene Stiegelmann

Technological expertise: CC, D-D, SMC, SY

Subsidiary of IKA Werke GmbH and Co. KG

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R&D expertise: Development and manufacture of thermometric equipment. Technological expertise: BME Principal products/instrumentation: DISPAX-REACTOR, ULTRA-TURRAX, IKASOFT, Viscok-lick. Main products/instrumentation under R&D: Thermometric instruments, calorimeter measuring devices. Sealed and granted patents: Calorimeter Measuring Device, Holding Fork R360, Support Rod Mounting R380.

1399

ILACON, LTD.

Add: Churchdown, Bordyke Tonbridge, Kent TN9 1NR U.K.

435

Subsidiary of ILEX Oncology, INC. R&D expertise: Research, development and manufacture of therapeutical drugs for cancer. Technological expertise: C/TC, PMC, SMC, SY Main products/instrumentation under R&D: Contract manufacturing products, contract research/clinical trial products, in vitro toxicology testing method. Subsidiary bodies: PFK-ILEX, SchraderstraBe 4, D-87600 Kaufbeuren, Germany, Tel: (49) 8341-9371-0, Fax: (49) 8341-9371-20; PFK-ILEX, 7 Walker St, Edinburgh EH3 7JY, U.K., Tel: (44) 131-220-4456, Fax: (44) 131220-4666.

1401

ILLUMINA, INC.

Tel: (44) 732-350-407 Fax: (44) 732-771-033 President/CEO: John Meakin R&D expertise: Research of diagnostics, cell and tissue culture, novel products development and manufacture.

Add: 9390 Towne Centre Drive Suite 200 San Diego, CA 92121 Tel: (619) 587-4290 Fax: (619) 587-4297 E-mail: [email protected]

Technological expertise: C/TC, P/S

Web site: www.illumina.com

Principal products/instrumentation: Ilacon brand ELISA equipment.

President/CEO: John R. Stuelpnagel (Acting President)

Main products/instrumentation under R&D: Cell and tissue culture, diagnostic drug, diagnostic enzyme, diagnostic kits, diagnostic reagents.

R&D expertise: Assembled arrays development, related products manufacture.

1400

ILEX ONCOLOGY SERVICES, INC.

Add: 11550 IH-10 West Suite 100 San Antonio, TX 78230 Tel: (210) 949-8200 Fax: (210) 949-8210 E-mail: [email protected] Web site: www.ilexoncology.com President/CEO: Richard L. Love

Technological expertise: G, PG, PMC, HTDS Principal products/instrumentation: miRNA Expression Detection, a new miRNA expression multiplexed assay, profiles the expression levels of a wide range of miRNA based on the DASL(cDNA-mediated Annealing, Selection, Extension and Ligation), 2008; HumanLinkage-12 Genotyping BeadChip, 2007; SNP/CNV Chip, 2007; IlluminaConnect, a new bioinformatics software partnership program established to advance data integration and analysis, 2007; Cancer Assay, 2007; Genotyping Chip: The chip contains markers for more than one million diverse genetic variants,

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all of which can be used for both wholegenome genotyping and copy number variation analysis. In addition to content currently found on the Human1M single-sample BeadChip, the Human1M-Duo features recently identified, disease-associated SNPs and intelligently selected, high-density SNPs in coding regions of the genome, 2009; DNA Analysis Chip: The Infinium® High-Density (HD) HumanCytoSNP-12 DNA Analysis BeadChip is for molecular cytogenetic research. The chip contains nearly 300,000 genetic markers per sample that target all known cytogenetic abnormalities found in genes and disease pathways linked to mental retardation, autism, and other common chromosome anomalies, 2009. Sealed and granted patents: Artificial intelligence and global normalization methods for genotyping, 7,035,740, U.S.

President/CEO: Timothy Chow R&D expertise: Reseach and manufacture of instrumentation for cell and tissue culture and fermentation process development. Technological expertise: F, BA, C/TC, CH/S, PMC Principal products/instrumentation: Equipment for processing samples in microplate wells. Q-sept automatic sterile sampler, Q-cell multiple bioreactor system, SX430 Modular Control System for cell culture and fermentation. Main products/instrumentation under R&D: UV light sterilized sampling devices, instruments for cell and tissue culture. Sealed and granted patents: UV light sterilized sampling device and method of sampling — U.S. patent #5,409,841.

1404 1402

IMAGING RESEARCH, INC.

IMAGELINE, INC.

Add: 13518 Normandie Ave. Gardena, CA 90249

Add: Brock University 500 Glenridge Ave. St. Catharines, Ontario L2S 3A1 Canada Tel: (905) 688-2040

Tel: (310) 329-5949

Fax: (905) 685-5861

Fax: (310) 329-3132

Web site: www.imagingresearch.com

President/CEO: Peter Chang

President/CEO: Peter Ramm, Ph.D.

Research director: Manny H. Kim

Research director: Peter Ramm, Ph.D.

R&D expertise: Development and manufacture of imaging system.

R&D expertise: Development and production of image analysis systems and detection systems; bioinformatics research.

Joint ventures: Eco Solutions. Technological expertise: CH/S Main products/instrumentation under R&D: Imaging system, imaging fluorimeter, imaging densitometer.

R&D collaboration: Amersham Pharmacia Biotech. Key license and trade contracts: Amersham Pharmacia Biotech. Technological expertise: CH/S, BI, G

1403

IMAGENE TECHNOLOGY

Add: P.O. Box 667 Hanover, NH 03755 Tel: (603) 448-9940 Fax: (603) 448-9960

Principal products/instrumentation: MCID and AIS image analyzers, Tundra ultra-low light imaging system, Discrete cell analyzer; Array vision. Main products/instrumentation under R&D: Image analysis systems.

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1405

IMARX PHARMACEUTICAL CORP.

Add: 1635 East 18th St. Tucson, AZ 85719 Tel: (520) 770-1259 Fax: (520) 791-2437 E-mail: [email protected] Web site: www.imarx.com President/CEO: Evan Unger, M.D. Research director: Thomas P. McCreery, MS R&D expertise: R&D of biopharmaceuticals; research and development of other drug products. Key license and trade contracts: Bracco, DuPont Merck. Technological expertise: AB, BS, C/TC, CH/S, DD, D-D, GA, GT, RD, PG Principal products/instrumentation: SonoRx. Main products/instrumentation under R&D: MRX-408 — A thrombus specific ultrasound contrast agent and sonothrombolysis enhancer; AALs — Acoustically active lipospheres — vehicles for the targeted delivery of drugs, e.g., chemotherapeutics, genes, antiinflammatories, etc. Sealed and granted patents: 60 U.S. patents and 20 foreign; Methods for delivering compounds into a cell, 6,743,779, U.S.

1406

interventional therapeutics and blood cell growth factors. R&D collaboration: American Cyanamid, E. Merck, INC. Abbot Labs. Technological expertise: Q, RD, P/S, H/CF, SY, C/TC Principal products/instrumentation: AmpliProbe DNA/RNA probe kit, BEC-2, IL-6, C-225 EFG receptor; Cetuximab(Erbitux), treatment of EGFR-expressing, metastatic colorectal carcinoma,2004. Main products/instrumentation under R&D: BEC2TM, Phase Ib/IIa; BEC2, Phase I; IL-6 Interleukin-6, IND filed; T-SCF; gp75 cancer therapeutic, development phase; gonorrhea vaccine, late preclinical studies; herpes vaccine, preclinical studies; bacterial meningitis vaccine, research phase; p53 for cancer therapeutic, research phase; IL-6 clinicals European 8c U.S. (IND accepted); C225, epidermal growth factor receptor, Phase Ib/IIa; C225 complete Phase I; Cetuximab(anti-EGFR chimeric MAb) to treat positive cancers, Phase II~III; Mitumomab(BEC-2, anti-GD3 MAb) for melamoma, small cell lung cancer, Phase III; IMC-IC11(anti-KDR chimeric antibody) for cancer or melanoma, Phase I~II. Subsidiary bodies: Manufacturing facility: Branchburg, NJ. Sealed and granted patents: Chimeric and humanized monoclonal antibodies specific to VEGF receptors, 6,448,077, U.S.

IMCLONE SYSTEMS, INC.

Add: 1860 Varick St. New York, NY 10014

1407

IMGEN TECHNOLOGIES

Tel: (212) 645-1405 Fax: (212) 645-2054 President/CEO: Samuel D. Waksal, Ph.D. Research director: Harlan W. Waksal, M.D. R&D expertise: Research of cell and tissue culture, human therapeutics for cancers and cancer related disorders, including cancer vaccines,

437

Add: Alexandria, VA 22313 Tel: (703) 549-2866 Fax: (703) 549-5439 E-mail: [email protected] Web site: www.imgen.com President: Beth Clark

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R&D expertise: Development of medicine/ drug scientific products in life sciences market.

1409

Joint ventures: Sciquest.com

IMI (TAMI) INSTITUTE FOR RESEARCH AND DEVELOPMENT LTD.

Contract unit of market sell: Alpha Immotech, Obiogene, Fermentas, Christ.

Add: P.O. BOX 10140 Hiafa Bay 26111 Israel

Technological expertise: N, RD, GA, G

Tel: (972) 4-846-9411

Principal products/instrumentation: Digital Imaging Systems; DNA/RNA purification kits; bacteria/yeast media; restriction enzymes, DNA/RNA/protein markers; rotational vacum concentrators and freeze dryers.

Fax: (972) 4-845-0078 E-mail: [email protected] Web site: www.tami-imi.com President/CEO: Dr. Gilead Fortuna Research director: Dr. R. Effenberger

1408

IMI INTERNATIONAL MEDICAL INNOVATIONS, INC.

Add: 5955 Airport Rd., Suite 222 Mississauga, ON L4V 1R9 Canada Tel: (905) 677-6235 Fax: (905) 677-4912 E-mail: [email protected]

Technological expertise: CC, PIS, SY Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, synthetic peptides. Main products/instrumentation under R&D: Peptides, containing N-alkyl amino acids, preclinical; skeleton for efficient presentation of antigenic sequences, preclinical.

Web site: www.imin.ca President/CEO: Dr. Brent Norton R&D expertise: Development of innovative products for rapid and early detection of lifethreatening diseases. R&D collaboration: MELT Co. — noninvasive rapid CF test; RCMR Ltd. — noninvasive cholesterol/glucose test. Contract unit of market sell: CA1-18; JCL Clinical Research (Knoxville, TN), Lithos: Pharmimex (Russia), Cholesterol Test: RCMR (Russia). Technological expertise: C/TC, ET Main products/instrumentation under R&D: Contract research/clinical trial products, noninvasive cholesterol test late stage clinicals; colorectal cancer detection test late stage clinicals; innovative products for rapid and early detection of life-threatening diseases. Sealed and granted patents: Two colorectal cancer patents pending; film strip patent pending.

1410

IMMGENICS PHARMACEUTICALS, INC.

Add: Suite 359-6660 North West Marine Drive Vancouver, BC V6T 1Z3 Canada Tel: (604) 732-7526 Fax: (604) 221-9112 E-mail: [email protected] Web site: www.imrngenics.com President/CEO: John Schrader R&D expertise: Development and manufacture of very high affinity therapeutic and diagnostic monoclonal antibodies. R&D collaboration: Corixa Corporation. Technological expertise: C/TC, D-D, GA, G, p/S, RD, Q, R Main products/instrumentation under R&D: Several very high affinity therapeutic monoclonal

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antibodies, preclinical; protein with a desired function.

Technological expertise: P/S, RD SMC, F, TE, AF, C/TC, D-D

Sealed and granted patents: U.S. Patent 5,627,052, “Methods for the Production of Proteins with a Desired Function.”

Main products/instrumentation under R&D: Contract manufacturing products, contract research/clinical trial products, DAP 092 (antiCryptosporidiosis), preclinical-Phase I; DB-289 (anti-pneumocystis carinii), preclinical-Phase I; rm CRP (anti-cancer), preclinical-Phase I.

1411

IMMUNOS

Add: 964 Ordway St Albany, CA 94706 Tel: (510) 525-5237

Sealed and granted patents: Over 30; Mutant protein and methods and materials for making and using it, 6,703,219, U.S.

Fax: (510) 525-0236 1413

E-mail: [email protected]

IMMUCELL CORP.

Web site: www.immunos.com Add: 56 Evergreen Dr. Portland, ME 04103

President: John Bergmann Technological expertise: PA, P, X Principal products/instrumentation: Diagnostics and R&D immunoassays, Affinity Purified Antibodies.

1412

IMMTECH INTERNATIONAL, INC.

Add: 150 Fairway Dr. Suite 150 Vernon Hills, IL 60061 Tel: (847) 573-0033

Fax: (207) 878-2117 President/CEO: Michael F. Brigham Research director: Joseph Crabb, Ph.D., Vice President and Chief Scientific Officer R&D expertiseR&D expertise: Development and manufacture of passive antibodies to prevent enteric infections in animals and humans. R&D collaboration: National Institutes of Health. Key license and trade contracts: Kamar, Inc. Technological expertise: F, PA, P/S, BA, C/TC

Fax: (847) 573-8288 E-mail: [email protected] President/CEO: T. Stephen Thompson Research director: Lawrence A. Potempa, Ph.D. R&D expertise: Drug development and manufacture of cancer and infectious diseases. Joint ventures: Nextera PharmEco Laboratories.

Tel: (207) 878-2770

Principal products/instrumentation: First Defense, Kamar Heatmount Detector. Main products/instrumentation under R&D: Oral antibody to prevent antibiotic associated diarrhea, Phase I trial complete; passive antibodies to prevents enteric infections.

Therapeutics,

R&D collaboration: University of North Carolina Research Consortium. Key license and trade contracts: ImmraRx, Inc., Criticare Systems, Inc.

1414

IMMUNA CARE CORP.

Add: 111 Research Dr. Bethlehem, PA 18015 Tel: (610) 861-6979 Fax: (610) 861-8247

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President/CEO: Thomas L. Hug, Ph.D. Research director: Thomas L. Klug, Ph.D. R&D expertise: Development and manufacture of in vitro diagnostic test kits for the detection and management of breast cancer and women’s estrogen-related diseases. Joint ventures: NET Ben Franklin Technology Center, Lehigh University Center for Molecular Bioscience and Biotechnology. Key license and trade contracts: The Rockefeller University. Technological expertise: C/TC, H/CF Principal products/instrumentation: Estravail for bioavailable estradiol, Estremet EIA for estrogen metabolism. Main products/instrumentation under R&D: In vitro diagnostics for detection and management of breast cancer and estrogen-related diseases.

Subsidiary bodies: 3030 Science Park Rd, San Diego, CA 92121. Sealed and granted patents: Many.

1416

IMMUNE NETWORK RESEARCH, LTD.

Add: 3650 Wesbrook Mall Vancouver, BC V6S 2L2 Canada Tel: (604) 222-5541 Fax: (604) 222-5542 E-mail: [email protected] Web site: www.knmunenetwork.com President/CEO: Dr. Allen Bain Research director: Dr. Allen Bain R&D expertise: Biotechnology medicines R&D, Commerce of biopharmaceutical information. Joint ventures: Bridge Pharma, INC.

1415

IMMUNE COMPLEX CORPORATION (ICC)

Add: 3347 Industrial Court San Diego, CA 92121 Tel: (800) 562-5544 Fax: (800) 793-2666 E-mail: [email protected]

Key license and trade contracts: University of British Columbia. Technological expertise: SMC, D-D Principal products/instrumentation: Therapeutics for Alzheimer, AIDS, Asthma, Herpes, Hepatitis and Cancer. Main products/instrumentation under R&D: 1F7 AIDS mAb, preclinical, antiaging agents, biotechnology medicines.

President/CEO: George B. Thornton Research director: George B. Thornton R&D expertise: Vaccines research and related products manufacture. Joint ventures: Cancer Therapeutics, INC. a subsidiary. Key license and trade contracts: New York University — Malaria Antigens

1417

IMMUNETICS, INC.

Add: 63 Rogers St. Cambridge, MA 02142 Tel: (617) 492-5416 Fax: (617) 868-7879 E-mail: [email protected]

Technological expertise: TE, BA, C/TC, D-D

President/CEO: Nancy Levy

Main products/instrumentation under R&D: Malaria vaccines, hepatitis C vaccines, cancer vaccines, malaria antigens, cancer therapeutics.

Research director: Andrew Levin R&D expertise: Healthcare and testing method, novel products design and manufacture.

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Technological expertise: P/S, H/CF Principal products/instrumentation: Miniblotters, Lyme Immunosis and Western Blot Kits. Main products/instrumentation under R&D: Healthcare medicines, immunomodulator, immunopotentiator.

1418

IMMUNEX CORP.

Add: 51 University St. Seattle, WA 98101 Tel: (206) 587-0430 Fax: (206) 587-0606

441

rheumatoid arthritis, psoriatic arthritis, chronic heart failure, etc., Phase III/IV; Leukine sargramostim (GM-CSF) to treat mucositis and cancer, Phase III/IV, venous stasis ulcers, Phase III/IV; Navance interleukin-4 receptor to treat asthma, Phase II/III; Avrend CD40 ligand to treat metastatic renal cell carcinoma, Phase II/III; epithelial solid tumors, Phase II; immune stimulation and immunomodulation in malignant melanoma, Phase III/IV; anti-tumor adjuvant/vaccine adjuvant, Phase II/III. Sealed and granted patents: Molecules designated B7L-1, 6,512,095, U.S.; Metalloprotease-disintegrin ADAM23(SVPH3-17) nucleic acids, 6,787,644, U.S.

Web site: www.irnmunex.com President/CEO: Michael Kranda Research director: Douglas Williams R&D expertise: Research, development and manufacture of hematopoietics and hematonic. Technological expertise: SMC, RD Principal products/instrumentation: Leukine (sargramostin), yeast derived GM-CSF, for autologous bone marrow transplantation; neutropenia resulting from chemotherapy in AML; allogeneic bone marrow transplatation; peripheral blood progenitor cell mobilization; Novantrone (mitoxantrone); Methotrexate; Thioplex (lyophilized thiotepa) approved new (methotrime formulation; Levoprome  prazine); Enbrel etanercept for moderat to severe active rheumatoid arthritis, for moderate to severe active juvenile rheumatoid arthritis. Main products/instrumentation under R&D: PEXY321, Phase III; Tumor necrosis factor receptor, Phase II; IL-1 receptor, Phase I; IL-4 receptor, Phase I; Multi-drug resistance reversal agent, preclinical; Orally bioavailable CSF inducer, preclinical; Monoclonal antibody conjugate, preclinical; IL-15, preclinical; Flt-3 ligand, preclinical; TAP1, preclinical; CD40 ligand, metastatic renal cell carcinoma, Phase II; Enbrel etanercept (recombinant soluble receptor) to treat disease modification of active

1419

IMMUNICON CORP.

Add: 3401 Masons Mill Road, Suite 100 Huntingdon Valley, PA 19006 Tel: (215) 830-0777 Fax: (215) 830-0751 E-mail: [email protected] Web site: www.immunicon.com President/CEO: Paul A. Liberti, Ph.D. Research director: Leon W. Terstappen, M.D., Ph.D. R&D expertise: Research of cellular diagnostics, and rare cell analysis, related products manufacture. Technological expertise: P/S, GA, C/TC Principal products/instrumentation: Cell separators and ferrofiuid for cell isolation (fetal cells from maternal blood) lymphocytes, subsets; EasyCount System, a fluorescent microscopy-based imaging system that counts dead and live nucleated cells, including mammalian cells, hybridomas, and ficoll preparations, and automatically calculates cell viability, all in a single test, 2007; EasyCount System, a fluorescent microscopy-based imaging system, 2007.

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Main products/instrumentation under R&D: Target Introduction — system for isolating epithelial tumor cells from whole blood (clinical research market), rare cell analyzer. Sealed and granted patents: 20 issued patents covering highly magnetic ferrofluids, high gradient magnetic separators, methods for cell separation and immunoassay.

1420

IMMUNO-BIOLOGICAL

Add: 1091-1, Naka Fujioka-Shi, Gunma 3750005 Japan Tel: (81) 274-222-888 Fax: (81) 274-235-746 E-mail: [email protected] Web site: www.mmjp.or.jp/ibl.co.jp

Tel: (800) 829-3194 Fax: (800) 888-8788 E-mail: [email protected] Web site: www.immunochemistry.com President/CEO: Gary L. Johnson Research director: Brian W. Lee, Ph.D. R&D expertise: Custom development of immunoassay development and contract manufacturing products, antibody development and production, antibody and protein purification/ conjugations. Technological expertise: PA, P/S, E, PMC Principal products/instrumentation: Enzymes, Monoclonal Antibodies, Polyclonal Antibodies, eLISAs Immunoassays, antibodies. Main products/instrumentation under R&D: Biosensors, porcine products, immunoassay reagents.

President/CEO: Tsutomu Seito Research director: Tsutomu Seito R&D expertise: Development and manufacture of antibodies, immunoassay kits.

1422

IMMUNO CONCEPTS, INC.

Technological expertise: PA, P/S, C/TC, H/CF

Add: 9779 Business Park Dr. Sacramento, CA 95827

Principal products/instrumentation: Contract research/clinical trial products, Rat GRO/CINC EIA kit; Rat Gro/CINC-1 EIAIBL; Rat Leptin EIA Kit, Rat Leptin EIA-ICL; Human osteopontin EIA kit, Human Osteopontin EIA-IBL; Human VEGF ELA Kit, Human VEGF EIA-IBL.

Tel: (916) 363-2649

Main products/instrumentation under R&D: Monoclonal and polycolonal antibodies, novel immunoassay kits.

R&D expertise: Development and manufacture of autoimmune disease diagnostics.

1421

IMMUNOCHEMISTRY TECHNOLOGIES, LLC.

Add: 9401 James Ave., South, Suite 155 Bloomington, MN 55431

Fax: (916) 363-2843 E-mail: [email protected] Web site: www.immunoconcepts.com President/CEO: Bert Williams III Research director: Carlos Del Bono

Technological expertise: PA, P/S, C/TC, CH/S, PMC Principal products/instrumentation: Diagnostics, Colorzyme ANA & DNA, Auto I.D, RELISA ENA and cardiolipin, HEp-2000. Main products/instrumentation under R&D: Autoimmune disease diagnostic kits, immunodiagnostic reagents.

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IMMUNO DIAGNOSTICS

443

Fax: (781) 255-1489 Web site: www.immunogen.com

Add: 4/26 Burrows Rd. Alexandria, NSW Australia

CEO: Mitchel Sayare, Ph.D.

Tel: (61) 2-9519-9300

Joint ventures: Apoptosis Technology, Inc.

Fax: (61) 2-9519-6762

R&D collaboration: SmithKline Beecham PLC (huC242-DMI), Biochem Pharma (Apoptosis Screens).

President/CEO: Martin Armstrong R&D expertise: Research of cytogenetics, cytology, immunology, related products development. Technological expertise: C/TC, G Key sales market contracts: Vysis, Orgentec, Zenyx Principal products/instrumentation: Biologicals, diagnostics, instrumentation, reagents. Main products/instrumentation under R&D: Cytogenetic screening, immunological adjuvant.

Research director: Walter Blattler, Ph.D.

Main products/instrumentation under R&D: huC242-DMI, Phase II; huN901-DMl, preclinical. Subsidiary bodies: Cambridge, MA.

1426

IMMUNOMEDICS, INC.

Add: 300 American Rd. Morris Plains, NJ 07950 Tel: (201) 605-8200

1424

IMMUNO-DYNAMICS, INC.

Add: 11055 Flintkote Ave. Ste.E San Diego, CA 92121 Tel: (800) 523-8803 Fax: (800) 452-3515 E-mail: [email protected] Web site: www.irnmuno-dynamics.com President/CEO: Tony Srouji, Ph.D. R&D expertise: Peptide synthesis and antibodies production.

Fax: (201) 605-8282 CEO: David M. Goldenberg, Sc.D., M.D. Research director: Hans Hansen, Ph.D. R&D expertise: Cancer and infectious disease disgnostics and therapy. R&D collaboration: Center for Molecular Medicine and Immunology. Key sales market contracts: European marketing and selling rights to CEA-Scan licensed to Mallinckrodt Medical, B.V.

Technological expertise: PI, PA, P, Q, SM, Y

Key license and trade contracts: Scimedx Corporation to sell in vitro kits.

Principal products/instrumentation: HF Apparatus; Catalogue peptides; Catalogue antibodies.

Technological expertise: B, C, S, D, F, N, G, H, PI, P, R, Q, Y

1425

IMMUNOGEN, INC.

Add: 333 Providence Hwy. Norwood, MA 02062 Tel: (781) 769-4242

Main products/instrumentation under R&D: CEA-Scan (Colorectal Cancer); LeukoScan (Infectious Diseases); CEA-Scan (Lung Cancer); LymphoScan (B-Cell Lymphoma); CEAScan (Breast Cancer); AFP-Scan (Liver and Germ Cell Cancers); PCP-Scan (Pneumocystis Carinii Pneumonia).

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IMMUNOSOURCE

Fax: (248) 652-0670 President/CEO: John Bacich Contacts

Add: Ruiterslaan 29 Halle-Zoursel, Antwerp B2980 Belgium

R&D expertise: Biopharmaceuticals.

Tel: (32) 3385-3685

Principal products/instrumentation: Albumin, FEIBA, IVEGGAM, and Bebulin.

Fax: (32) 3384-3818

Technological expertise: B, M, P

E-mail: [email protected] Web site: www.immunosource.com President: P. Snyers

1430

IMMUNOVISION, INC.

R&D expertise: Immunology and molecular biology.

Add: 1820 Ford Ave. Springdale, AR 72764

Key sales market contracts: BioProcessing; Cymbus Bioscience; Severn Biotech; Nanoprobes; Bachem; Bender Medsystems; Europa Bioproducts, Biognostic, Europa BioProdcucts, Equibio, CPG, INC. Cortex Biochem, Actigen and MBL, INC.

Fax: (501) 751-7002

Technological expertise: PA, Q, B, TE, T

Technological expertise: C, H, PA, P

Principal products/instrumentation: Cytokine ELISA’s; CPG Purification Matrices; Antibodies, in vitro toxicology, biologicals, reagents.

Principal products/instrumentation: Affinity Purified Antigen.

Tel: (501) 751-7005 President/CEO: Kevin Clark Subsidiary of Ivax Corp. R&D expertise: Production of antigens, purification of antibodies.

1431 1428

IMMUNOTECH LABORATORIES, CTTC

IMPATH, INC.

Add: 521 West 57th St. 6th Floor New York, NY 10019

Add: 11796 Wilcrest Drive Houston, TX 77099

Tel: (212) 702-8300

Tel: (281) 495-2558

Fax: (212) 759-4869

Fax: (281) 495-2471

E-mail: [email protected]

President/CEO: Kongwei Huang

Web site: www.impath.com

Technological expertise: H, PA, P

President/CEO: Anu D. Saad, Ph.D.

Markets: Biologicals

Research director: Yiatin Chu

Main products/instrumentation under R&D: Hybridoma, monoclonal antibody, polyclonal antibody, protein and antibody purification.

R&D expertise: Research and development and cancer diagnosis, prognosis, treatment determination, outcomes focused database, other drugs preclinical research, clinical trial support.

1429

IMMUNO-U.S., INC.

Add: 1200 Parkdale Rd. Rochester, MI 48307 Tel: (248) 652-7872

Technological expertise: PA Main products/instrumentation under R&D: contract research/clinical trials products, pharmaceuticals.

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Subsidiary bodies: 5230 Pacific Concourse Dr., Suite 450, Los Angeles, CA 90045.

1434

445

IMUTRAN, LTD.

Add: 18 Trumpington Rd. Cambridge CB2 2AH U.K. 1432

IMPERIAL COLLEGE INNOVATIONS, LTD.

Tel: (44) 122-330-0151 Fax: (44) 122-330-0153

Add: 47 Prince’s Gate Exhibition Road London SW7 2QA U.K.

President/CEO: Christopher Samler

Tel: (44) 171-581-4949

R&D expertise: Research of Xenotransplantation and complement regulation, related products manufacture.

Fax: (44) 171-589-3553 E-mail: [email protected] Web site: www.icinnovations.co.uk President/CEO: Dr. Jonathan Gee

Research director: Dr. D. J. White

Technological expertise: C, TE, T, C/TC Main products/instrumentation under R&D: Organ transplants/culture products.

Research director: Dr. Jonathan Gee R&D expertise: Technology transfer of biotechnology medicines products

1435

INALCO-PHARMACEUTICALS

Key license and trade contracts: Pharmacia & Upjohn, SmithKline Beecham.

Add: 423 Sargon Way Horsham, PA 19044

Technological expertise: GT, H/CF, PG, RD, CH/S, BI, COC, DD, TE, PA

Fax: (805) 782-0719

Principal products/instrumentation: Biologicals, instrumentation, organ transplants/ culture products, pharmaceuticals, reagents.

1433

IMPERIAL LABORATORIES (EUROPE), LTD.

Tel: (805) 782-0718 R&D expertise: Development and manufacture of carbohydrates and carbohydrate intermediates for diagnostics and therapeutics. Technological expertise: CB, CS Principal products/instrumentation: IPTG, X-GAL, OCTYL-Glucoside & X-GLUC for microbiology and molecular biology. Lactulose and carbohydrates for therapeutics.

Add: West Portway Andover, Hampshire SP10 3LF U.K.

Main products/instrumentation under R&D: Polysaccharides and synthetic heparin derivatives.

Tel: (44) 126-433-3311

Subsidiary bodies: Inalco Pharmaceuticals (sales/marketing), 670 Marsh St., San Luis Obispo, CA 93401; Inalco S.PA, Via Calabiana, 18, 20139 Milano, Italy.

Fax: (44) 126-433-2412 President/CEO: George C. Graham R&D expertise: Life science research, Cell and tissue culture development and manufacture. Technological expertise: C/TC, BA Principal products/instrumentation: Cell lines, media iomatrices.

1436

INCELL CORPORATION, LLC.

Add: 12000 Network Blvd., Ste. B-200 San Antonio, TX 78249

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Tel: (210) 877-0100

Technological expertise: CS, C/TC, GA, GT, G

Fax: (210) 877-0200

Principal products/instrumentation: Paper labels for status identification to prevent mixups; reusable stamps for document status identification; useful books for the industry; industry relevent ANSI, ISO, ASQC and CENELAC standards and guidelines; training videos for GMP, GLP, GCP compliance; FDA documents and guidelines.

E-mail: [email protected] Web site: www.incell.com President/CEO: Mary Pat Mover, Ph.D. Research director: John Kanalas, Ph.D. R&D expertise: Preclinical testing and research services; specialty media and supplements to grow cells and tissues; therapeutics from cells, tissues and genes; diagnostics. R&D collaboration: University of Texas Health Science Center at San Antonio, Stehlin Foundation for Cancer Research, University of Arkansas for Medical Sciences; outers. Technological expertise: B, PA, E, BA, C/TC, DD, GT, HTDS, H/CF, PMC, R Principal products/instrumentation: Cell culture media and supplements M3, M3: 2, M3: 5; M3: 10, M3: 20~, SMX, 1994; contract research services, CPZ, UTM. Main products/instrumentation under R&D: INCELL-AFFA nutraceutical, Phase III; Diagnostic and R&D reagents for HHV8, Phase III; Cell, gene and tissue based therapies, preclinical. Sealed and granted patents: Trade secret: M3 media patents pending on other products.

1437

IN COMPLIANCE SYSTEMS, INC.

Add: 455 Los Gatos Blvd # 205 Los Gatos, CA 95032 Tel: (408) 358-4550 Fax: (408) 358-4554 E-Mail: [email protected] Web site: www.netcorn/~cbardes/ics.html

1438

INCYTE PHARMACEUTICALS, INC.

Add: 3160 Porter Dr. Palo Alto, CA 94304 Tel: (415) 855-0555 Fax: (415) 855-0572 E-mail: [email protected] Web site: www.incyte.com President/CEO: Roy A. Whitfield R&D expertise: Development of Genomic databases; custom development services and software; biological reagents manufacture. R&D collaboration: Affyrnetrix, INC. CNRS; GeneTrace Systems, INC.; Mayo Clinic; Oceania, INC.; SAIC; Scriptgen Pharmaceuticals, INC.; Vysis, INC. Technological expertise: D-D, P/S, RD, R, Q, SMC, BI, CH/S Principal products/instrumentation: LifeSeq; LifeSeq FL; LifeSeq Atlas; PathoSeq; LifeTools; LifeSeq GeneAlbum. Main products/instrumentation under R&D: PhytoSeq; ZooSeq. Subsidiary bodies: Pasadena, CA, U.S.A.; Genome Systems, Inc. (a wholly owned subsidiary), St. Louis, MO, U.S.A.

President/CEO: Christine B. Bardes R&D expertise: Supply products to help biotech medicines companies comply with FDA regulations & the voluntary ISO 9000 standards.

1439

INDENA SPA

Add: Viale Ortles 12 Milan 20139 Italy

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Tel: (39) 2-574-961

E-mail: [email protected]

Fax: (39) 2-574-462

President/CEO: Ron Zimmerman

E-mail: [email protected]

Research director: Ron Zimmerman

Web site: www.indena.it

R&D expertise: Research, development and manufacture of enzymology, recombinant DNA and polyclonal antibodies.

President/CEO: Mr. Giusspa Palianti Research director: Dr. Bruno Gabetta R&D expertise: Research, development and manufacturing of new plant-derived principler. Technological expertise: E, F, P/S, C/TC Principal products/instrumentation: Thiocolchicoside, 10 Deacetylbac-catine III, Paclitaxel, Ruscogenins. Main products/instrumentation under R&D: Colchiclnoids.

Technological expertise: E, F, PA, G, PMC, P/S, RD, BI, BA, C/TC Main products/instrumentation under R&D: Contract manufacturing, contract research/ clinical trials products.

1442

INDUSTRIAL RESEARCH, LTD.

Add: Box 31-130 Lower Hutt New Zealand Tel: (64) 4-569-0000 1440

INDIANA BIOLAB

Add: 14045 Huff Street, NE Palmyra, IN 47164-8872

Fax: (64) 4-569-0132 E-mail: [email protected] Web site: www.irl.cri.nz

Tel: (812) 364-6739

President/CEO: Dr. Geoff Page

E-mail: [email protected]

Research director: Max Kennedy

President/CEO: Harold Eddleman, Ph.D.

R&D expertise: R&D for manufacturing and processing industry, biomanufacturing; bioprocess engineering research/development.

R&D expertise: Research and manufacture of plant breeding, maize and small fruits, micropropagation of virus-free sweet potato. Technological expertise: C/TC, CH/S Principal products/instrumentation: Micropropagated virus-free sweet potato and small fruit plants for foundation stock for nurseries; microbial cultures for education, research and reference.

1441

INDIANA PROTEIN TECHNOLOGIES, INC.

Add: 122 South Park Blvd. Greenwood, IN 46143 Tel: (317) 865-4770 Fax: (317) 865-4775

R&D collaboration: New Zealand Dairy Board, Anchor Products Ltd., N.Z, Zeneca Agrochemicals U.K., Zeneca Pharmaceuticals U.K., National Cancer Institute, U.S.A., Ariad Pharmaceuticals, U.S. Key license and trade contracts: Monsanto NZ Ltd.; Anchor Products Ltd., N.Z; Stolle R&D Corp. U.S. Technological expertise: E, F, P/S, BA, C/TC, PMC, CH/S, SY, GT, LP, RD Main products/instrumentation under R&D: Bioinsecticides, insect cell culture, scale-up recombinant fermentations, design of fermenters for mycelial non-newtonian fermentations, immobilized enzyme reactors, immobilized cell reactors, specialty lipids from fungi, neural networks, extraction of complex

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lipids from animal tissue, chromatographic separation media, meat hydrolysate flavors, extraction of enzymes and biopolymers from animal tissue, chemprocessing, supercritical CO2.

President/CEO: David J. Main Research director: Dr. Pieter Cullis R&D expertise: Oncology; Research of development of drug delivery for cancer therapeutic agent. Joint ventures: Proligo Thloates, LLC.

Add: Velazquez, 31 Madrid 28001 Spain

R&D collaboration: Ribozyme Pharmaceuticals, INC. Sequitur, INC. Copernicus Gene Systems, British Columbia Cancer Agency, and University of British Columbia.

Tel: (34) 1-435-9080

Technological expertise: AB, DD

Fax: (34) 1-575-5467

Main products/instrumentation under R&D: Onco TCS-, Pivotal, Phase II; INXC-6295, Phase I; INX-3280, Phase I.

1443

INDUSTRIAS AGROBIOLOGICAS, S.A.

E-mail: [email protected] Web site: www.inagrosa.es

Subsidiary bodies: Antisense manufacturing.

President/CEO: O. Fernandez Research director: J. R. Delgado R&D expertise: Research and manufacture of RPG kits for bioremediation. Joint ventures: Wilstar Co., Malaysia. Key license and trade contracts: Biotecnica.

1445

INFECTIO DIAGNOSTIC (I.D.I.), INC.

Add: 2050 Rene Levesque Blvd. West 4th Flr. Sainte-Foy, Quebec GIV2K8 Canada

Technological expertise: F, BA, C/TC, PB, PMC, SY

Tel: (418) 681-4343

Principal products/instrumentation: AminoLForte; Fosnutren; Kadostim; Humiforte; Bactysoil; Aminorgan; Grinfol. contract manufacturing products, contract research/clinical trials products.

E-Mail: [email protected]

Main products/instrumentation under R&D: Neurolar, preclinical; Face-CNS degenerative diseases, preclinical.

R&D expertise: Research development manufacture and marketing of genomic products intended for the detection and identification of infectious agents.

1444

INEX PHARMACEUTICALS CORP.

Add: 100-8900 Glenlyon Parkway Burnaby, British Columbia V5J 5J8 Canada Tel: (604) 419-3200 Fax: (604) 419-3201 E-mail: [email protected] Web site: www.inexpharm.com

Fax: (418) 681-5254 Web site: www.infectio.com President/CEO: Dr. Pierre Coulombe, Ph.D. Research director: Dr. Michael B. Bergeron

Joint ventures: Ft. Ridia — automated rapid identification and detection of infectious agents (I.D.I, Ste- Foy and Cepherd California). Technological expertise: Q, GA, GT, G Principal products/instrumentation: Identify group B strings on pregnant women., Amphiistrep B, 2001 products, contract research/ clinical trials products. Main products/instrumentation under R&D: 10 diagnostic tests ( Molecular technology).

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INFIGEN, INC.

Add: 1825 Infinity Drive De Forest, Wl 53532

1448

449

INFOMETRIX, INC.

Tel: (608) 846-0500

Add: 17270 Wood-Red Rd. NE #777 P.O. Box 1528 Woodinville, WA 98072-1528

Fax: (608) 846-0520

Tel: (425) 402-1450

E-mail: [email protected]

Fax: (425) 402-1040

Web site: www.infigen.com

E-mail: [email protected]

President/CEO: Michael D. Bishop, Ph.D.

President/CEO: Brian G. Rohrback

Research director: Michael D. Bishop, Ph.D.

Research director: Scott Ramos

R&D expertise: Biotech medicines commercializing applications of nuclear transfer and related technology in the human healthcare and agriculture industries.

R&D expertise: Development and manufacture of scientific software.

Technological expertise: T, C/TC, G Main products/instrumentation under R&D: Agriculture, biotech medicines.

1447

INFLAZYME PHARMACEUTICALS, LTD.

Technological expertise: M, S Principal products/instrumentation: Pirouette; Instep; Ein Sight InfoMax.

1449

INFORMAX, INC.

Add: 6010 Executive Blvd. 10th Floor North Bethesda, MD 20852 Tel: (301) 984-2206

Add: 5600 Parkwood Way Suite 425 Richmond, BC V6V 2M2 Canada

Fax: (301) 216-0087

Tel: (604) 279-8511

Web site: www.informaxinc.com

Fax: (604) 279-8711

President/CEO: Dr. Alex Titomirov

E-mail: [email protected]

Research director: Vadim Babenko

Web site: www.inflazyme.com

R&D expertise: R&D of artificial intelligence programming for biomedical market; Molecular biology software; Consulting/software development. Research of drug discovery, enabling pharmaceutical, biotechnology and research organizations worldwide to achieve greater insights through biological data-mining and integrated sequence analysis.

President/CEO: Ian McBeath Research director: Kevin Mullare, Ph.D. R&D expertise: Inflammation drugs research and development. R&D collaboration: Auentis pharma S.A. Key sales market contracts: Auentis Pharma S.A.

E-mail: [email protected]

Key license and trade contracts: Auentis Pharma S.A, University of British Columbia.

R&D collaboration: AxCell Corporation, French National Center for Scientific Research, TimeLogic Sun, Compaq, Apple, Viaken.

Technological expertise: SMC

Technological expertise: G, CH/S, BI

Principal products/instrumentation: IPL576 (Asthma); IPL423 (Arthritis).

Principal products/instrumentation: Vector NTT Suite desktop sequence analysis and data

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management, software package; Geno Max, enterprise bioinforrnatics system. Subsidiary bodies: Sales: The Magdalen Centre, Robert Robinson Ave, The Oxford Science Park, Oxford, 0X4 4GA U.K., Tel: 44 1865784-4580; 395 Oyster Point Blvd, Ste. 213, South San Francisco, CA 94080, U.S.A., Tel: (650) 616-0056, Fax: (650) 616-9274. Technical Service: 433 Park Point Dr., Gardiner Plaza Office Bldg, Ste. 275, Golden, CO 80401, Tel: (720) 746-1122.

Walnut St., Allentown, PA 18102-4826, U.S.A., Tel: (610) 776-2564; Fax: (610) 4437516; Tannenweg 3,85254 Germany, Tel: (49) 81 358333, Fax: (49) 81 358320.

1451

INGENIOUS TARGETING LABORATORY, INC.

Add: LIHTI Building, Suite 106 25 E. Loop Road Stony Brook, NY 11790 Tel: (516) 444-6640

1450

INFORS AG

Fax: (516) 444-6645 E-mail: [email protected]

Add: Rittergasse 27 Bottmingen CH-4103 Switzerland Tel: (41) 61-425-7700 Fax: (41) 61-425-7701 E-mail: [email protected] Web site: www.infors.ch President/CEO: Alexander Hawrylenko Research director: Alexander Hawrylenko R&D expertise: Research of bioprocess automation, computer hardware/software and cell/tissue culture; products manufacture R&D collaboration: University of Zurich, University of Neuchatel. Technological expertise: F, BA, C/TC, PMC, CH/S Principal products/instrumentation: Shakers and, incubator shakers: Labotron, Aquation, Aerotron, Novotron, Unitron, Mttltitron; Bench-top and pilot plant fermenters: Profors, Sixfors, Labfors, Techfors; Softwares: Iris; Minitron. Subsidiary bodies: Infors GmbH, Infors s.a.r.1., ZI de la bonde, 6 Rue Marcel Paul, 91742 Massy, France, Tel: (33) 169 309504, Fax: (33) 169 309505; In-fors U.K., Ltd., 10 Bridgeman Terrace, Wigan, Lancashire, WN1 1SX, Great Britain, Tel: (44) 942 825025, Fax: (44) 942 820412; Infors Biotech, INC. 823 W.

Web site: www.genetargeting.com President/CEO: Wei Weng CFO: Ellen Chen Research director: Wei Weng R&D expertise: Mouse gene targeting/gene knock-out. Technological expertise: T, Q, RD, G, SY, C/TC Principal products/instrumentation: Agriculture, biologicals, human genome project, contract research/clinical trials products

1452

INGENY INTERNATIONAL BV

Add: Amundsenweg 71 Goes 4462 GP Netherlands Tel: (31) 113-222-920 Fax: (31) 113-222-923 E-mail: [email protected] Web site: www.ingeny.com. President/CEO: Gert J. De Vos Research director: R. Cammaert R&D expertise: Development of mutation analysis, equipment and kits; novel products manufacture. R&D collaboration: University of Groningen, The Netherlands.

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Technological expertise: BME, P, PAT, DK Principal products/instrumentation: Human genome project, instrumentation, reagents, ENGENphorU — system for mutation detection, INGENYphorU; DNAlyser 2-D electrophoresis automate, DNAlyser; CFTR-kit for mutation detection; p53-kit for mutation detection, 2D- proteine elctrororesis automate; BRCAI and BRCAZ test kits; MCHZ, MSHZ.MSH6 test kits. Main products/instrumentation under R&D: Capillary gradient electrophoresis system. Sealed and granted patents: INGENYphorU DGGE system (also for other gels); DNAlyser 2-D, electrophoresis system. 1453

INGOLP/METTLER TOLEDO, INC.

Add: 261 Ballardvale St. Wilmington, MA 01887 Tel: (978) 658-7615 Fax: (978) 658-0020 E-mail: [email protected] Web site: www.MT.com President/CEO: Robert Azimi Research director: Suresh Yenisetti R&D expertise: Research, development, manufacture and marketing of pH, dissolved oxygen, conductivity turbidity sensors, housings, and transmitters. Technological expertise: PMC Principal products/instrumentation: Ingold DPAS, InPro, dissolved oxygen sensors, InFit and InTrac housings. Main products/instrumentation under R&D: Infit CIP Sterilizable Housing is 3A and EHEDG certified and ISO 9001. 1454

INHALE THERAPEUTIC SYSTEMS

Add: 150 Industrial Rd. San Carlos, CA 94707

451

Tel: (650) 631-3100 Fax: (650) 631-3150 Web site: www.inhale.com President/CEO: Robert Chess Research director: John S. Patton, Ph.D. R&D expertise: Development and manufacture of drug delivery products in the field of pulmonary drug delivery of macromolecules. R&D collaboration: Pfizer, Lilly, Biogen, Centeon. Key license and trade contracts: Genentech, INC. Pafra Biopreservation. Technological expertise: DD, RD, R, P/PS Main products/instrumentation under R&D: Insulin pulmonary delivery system, Phase III; IL-1 receptor delivery system, Phase I/II; Calcitonin delivery system, formulation development-Phase I; Alpha-1 antitrypsin, preclinicals; Interferon beta delivery system, preclinical; Osteodrug, Phase I. Subsidiary bodies: 1525 Industrial Way, Belmont, CA 94002. Sealed and granted patents: Method and device for delivering aerosolized medicaments.

1455

INKINE PHARMACEUTICAL COMPANY, INC.

Add: Sentry Park East 1720 Walton Rd Blue Bell, PA 19422 Tel: (610) 260-9350 Fax: (610) 260-9355 E-mail: inkine.com Web site: www.inkine.com CEO: Leonard S. Jacob, M.D., Ph.D. Research director: Barbara Nagle, Ph.D. R&D expertise: Diagnosis and treatment of cancer and autoimmune diseases, related therapeutical products development and manufacture.

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Key license and trade contracts: University of Pennsylvania, MCP Hahneman University.

E-mail: [email protected]

Technological expertise: AB, G

President/CEO: Edmundo Medina/Harold Fraile

Main products/instrumentation under R&D: Diacol (Purgative prior to colonoscopy), pending NDA submission; CBP1011 (Treatment of ITP), Phase III, Thrombospondin (metasis of cancer), preclinical.

1456

INMARK, INC.

Add: Atlanta, GA 30336 Tel: (404) 267-2020 Fax: (404) 267-2021 E-mail: [email protected] Web site: www.thomasregister.com/inmark President/CEO: David L. Oyler R&D expertise: Research of packaging for infectious and diagnostic samples; products manufacture. Technological expertise: CS, C/TC, FE Principal products/instrumentation: IDS (infectious and diagnostic shipping) systems. Subsidiary bodies: Inmark, Inc. Birmingham Branch/warehouse #02, 165 Goodrich Dr., Suite 101, Birmingham, AL 35217-1465; Greensboro Branch/warehouse #03,8301 Triad Dr., Greensboro, NC 27409-9621; Jacksonville Branch/warehouse #04, 600 Suemac Rd., Suite 4, Jacksonville, FL 32254-2700; Nashville Branch/warehouse #05,3330 Ambrose Ave., Space Park East, Nashville, TN 37207-4716.

1457

INMUNOLAB LABORATORIOS

Web site: www.inmunolab.com Ginter/Carlos

Research director: Carlos Medina R&D expertise: Development and manufacture of high-tech products for clinical diagnosis and biomedical research. Key sales market contracts: Amersham Pharmacia Biotech, Beckman Coulter Inst., Becton Dickinson, Immunocytometry Systems, Digene Diagnostics, Wallac OY Technological expertise: BA, C/TC, GA, HTDS, PA, PMC, P/S, RD, R, H/CF, Q Principal products/instrumentation: Delfia Fluorometry/gamma and beta counters, Wallac OY; Facscan/Facsert/Facscalibur flow cytometers, Becton Dickinson; Ultra/High Performance centrifugues (AVANTI), Beckman; HPLC/ Capillar Electrophoresis (PACE), Beckman. Subsidiary bodies: Inmunolab Columbia: Trans Vereal 9, No 55-89, Santa Fe De Bogota, Columbia, Tel: (57) 1 592 3009, Fax: (57) 1 217 7147, General Manager — Wis Alfonso Pachon, [email protected]; Inmunolab Costa Rica: Apartado Postal 1232-10114, San Jose, Costa Rica, Barrio Cordoba, 100 Mts, Iglesia Nuestra Senor de Vjarras, Tel: (50) 6 227 8310, Fax: (50) 6 226 5385 [email protected].

1458

INMUTEC, SA DE CV.

Add: LaPlace 26 PR, Col. Anzurez Mexico, D.F. 11590 Mexico Tel: (52) 5545-1023 E-mail: inmutec-data.net.mx

Add: Los Ruices, C. Los Laboratorios Edificio Ofinca, Piso 4, Ofic. 92 Caracas, D.F. 1071 Venezuela

President/CEO: Ing. Guillermo Rendon Padilla

Tel: (58) 2-237-0780

R&D expertise: Development and marketing bioproducts and equipment for the same fields.

Fax: (58) 2-234-6176

Research director: Agustin Nunez

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R&D collaboration: Diagnostika and Real DY V Technological expertise: PA, T, P/S, RD Principal products/instrumentation: HLA System serological and P.C.R., LNMUTEC; Biological Insecticidas, DyV. Main products/instrumentation under R&D: Fibrine Autologous, preclinical.

1459

INNOGENETICS N.V.

453

Main products/instrumentation under R&D: M-24, KSF, preclinical; HTLV, LIA HTLV, HBV, HCV, TB vaccine. Sealed and granted patents: HCN, HIV-1 Group O

1460

INNOGENEX

Add: 4600 Norris Canyon Road San Ramon, CA 94583 Tel: (925) 543-1400

Add: Industriepark Zwijnaarde 7, Box 4 Zwijnaarde, Ghent B-9052 Belgium Tel: (32) 9-241-0711 Fax: (32) 9-241-0799 E-mail: [email protected]. com Web site: www.imotion.be/IHOME/Cyberstore President/CEO: Hugo Van Heuverswyn, Ph.D. Research director: Andre Vandevoorde, Ph.D. R&D expertise: Research, development and manufacture of therapeutical drug for infectious diseases, wound healing, CNS and genetic disorders, AIDS; Research/development/ production/marketing, diagnostics and therapeucutic programs. R&D collaboration: Boehringer Mannheim, Murex. Key sales market contracts: Boehringer Mannheim, H.L. Roche, Murex, Organon, Sorin, Toa Medical, Daikin. Key license and trade contracts: Kaneka, Chiron, Boehringer Mannheim, BRI.

Fax: (925) 543-1405 E-mail: [email protected] Web site: www.innogenex.com President/CEO: Satya Kalra Research director: Bob Xue R&D expertise: Development and manufacture of Reagents and kits for molecular and cellular analysis of gene expression. Technological expertise: E, PA, PMC, P/S, AB, C/TC Principal products/instrumentation: Mouseon-Mouse Immunohistochemistry Kit — ISOIHC; Universal Multi-Application Detection Kit, Uni-MAK; InnoGenex ISH Kit, InnoGenex IHC Kit; Primary Antibodies, Oligonucleotide Probes. Specialty chemicals, monoclonal antibodies, antibiotics, single cell proteins.

1461

INNOVATIVE BIOSYSTEMS, INC.

Add: 121 Sweet Ave. Moscow, ID 83843-2386

Technological expertise: P/S, BA, GA, H/CF, Q, E, PMC, RD, CH/S, SY, D-D, PB

Tel: (208) 885-3884

Principal products/instrumentation: Innotest LIA HCV, Innotest LIA HIV, Innotest Lp(a), Inno-LiPA HLA, Innotest hTAU, Inno-LiPA Apo E, Cytokine kits, Inno-Lipa Rif. TB; LiPA HIV-1 RT, INNO-LIA ANA.

E-mail: [email protected]

Fax: (208) 885-3819 Web site: www.palouse.net/ibs President/CEO: Roger A. Konis Research director: Mark Roberts

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R&D expertise: Research & development of bio reaction agents Joint ventures: New Bio, Inc. Technological expertise: P/S, AF, BA, GA Principal products/instrumentation: Anaerobic wastewater treatment systems, microbial biocontrol agents. Main products/instrumentation under R&D: (i) Methods for tagging explosives and other commodities, R&D; (ii) surfactants, biodegradable and hydrolyzable, R&D. Sealed and granted patents: Bioreactor.

1462

INNOVATIVE BIOTECHNOLOGIES INTERNATIONAL

Add: 335 Lang Blvd. Grand Island, NY 14072 Tel: (716) 773-4232

number of out-Contract Unit of License Trade are currently being negotiated to provide access to the company’s intellectual property portfolio in various market niches. Technological expertise: GA, G, HTDS, PMC Principal products/instrumentation: Liposomal-based, microchip-enhanced detection system capable of being used in multiple market ruches. Main products/instrumentation under R&D: IBI continually pursues use of its liposomalbased, microchip-enhanced detection system in multiple market ruches. Sealed and granted patents: A portfolio of issued U.S. patents covering the liposomalbased diagnostic and the microchip-based detection system are exclusively licensed to IBI. A growing list of foreign applications covering the same technologies are currently being prosecuted.

Fax: (716) 773-4257 E-mail: [email protected] Web site: www.ibi.cc President/CEO: Richard A. Montagna, Ph.D. R&D expertise: Exclusively license university technologies and establish strategic relationships with other companies to commercialize product(s) based upon the technologies; Inlicense and out-license biotechnologies. R&D collaboration: NYSERDA contract to develop and commercialize a microchip-based test for the detection of cryptosporidium parvum in drinking water. “Teaming Agreement” with ITT Industries to develop a microchip-based detection system for the detection of chemical and biological warfare agents. Key license and trade contracts: Exclusive worldwide in-license from Cornell University to make, use, and sell a rapid, microchip-based detection system for the detection of chemical or biological analytes in all fields of use. A

1463

INNOVATIVE CELL TECHNOLOGIES, INC.

Add: 11575 Sorrento Valley Rd #208 San Diego, CA 92121 Tel: (858) 755-7407 Fax: (858) 259-5268 E-mail: [email protected] Web site: www.innovativecelltech.com President/CEO: C. Kevin Becker Research director: Eric Pease R&D expertise: Development and manufacture of tissue culture products. Technological expertise: C/TC, DK Principal products/instrumentation: Apoptosis Reagent Kit, APOBRDM; Apoptosis Reagent Kit, APODIRECT; Cell Proliferation Reagent Kit, ABSOLUTE-S; Combined Apoptosis/Proiiferation Kit, LIFE and DEATH Assay.

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Main products/instrumentation under R&D: Specific MRNA isolation kit, Oligo profile labeling kit.

455

Tel: (450) 922-4666 Fax: (450) 922-7776 President/CEO: Daniel Couillard Research director: Steve Teasdale

1464

INNOVATIVE CHEMISTRY, INC.

Add: PO Box 90 Marshfield, MA 02050

R&D expertise: Research of environmental biotechnology: wastewater treatment hygiene, and related products manufacture.

Tel: (781) 837-6709

Technological expertise: F, C,W

Fax: (781) 834-7325

Principal products/instrumentation: Environmental wastewater treatment equipment.

Web site: www.authentikit.com President/CEO: Dr. J. M. Ziegenmeyer R&D expertise: Quality control, products manufacture and process validation. Technological expertise: E, H/CF, C/TC, P/S, G Principal products/instrumentation: Authentikit System; Authentifolm Agarose Gels; Authentizyme, Enzyme Stabilizer.

1467

INOTECH BIOSYSTEMS INTERNATIONAL, INC.

Add: 15713 Crabbs Branch Way #110 Rockville, MD 20855 Tel: (800) 635-4070 Fax: (301) 670-2859 E-mail: [email protected]

1465

INNOVATIVE SENSORS, INC.

Add: 4745 E. Bryson St. Anaheim, CA 92807

Web site: www.inotechind.com President/CEO: Dr. Othmar Kuhn

Fax: (714) 779-9315

R&D expertise: Distribution and marketing of biomedical research equipment manufactured by Inotech AG.

E-mail: [email protected]

Technological expertise: TE, C/TC, BME

Web site: www.innovativesensors.com

Principal products/instrumentation: Cell encapsulator, cell harvester, steriguard benchtop sterilizer, sterilizer vacuum/compression pump station, vacuset handpiece liquid aspirator/ dispensor, vacubottle vacuum bottle.

Tel: (714) 779-8781

President/CEO: Gary L Bukamier R&D expertise: Development and manufacture of electrochemical devices. Technological expertise: PMC Principal products/instrumentation: pH electrodes; ion-selective electrodes, platinum label. Sealed and granted patents: # 4,333,812, #4,128,468, #4,620,918.

1466

INNU-SCIENCE

Add: 1777 Nobel Blvd Local F Julie, Quebec J3E 126 Canada

1468

INOVA DIAGNOSTICS, INC.

Add: 10180 Scripps Ranch Blvd. San Diego, CA 92131 Tel: (858) 586-9900 Fax: (858) 586-9911 E-mail: [email protected] Web site: www.inovadx.com

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President/CEO: Walter L. Binder, Ph.D.

Technological expertise: E, BA, PMC

Research director: Walter L. Binder, Ph.D.

Principal products/instrumentation: Egg white avidin, trypsin, ovo-transferrin, lysozyme chloride, chymotrypsin, ovalbumin, lecithin, hyaluronic acid, ovomucin, phospholipase.

R&D expertise: R&D, manufacture and marketing of autoimmune disease diagnostics. Technological expertise: P/S, C/TC Principal products/instrumentation: Nova Lite IFA; Nova Gel™ ENA; Quanta Lite ELISA.

1469

INOVATA AB

Add: Annedalsvagen 39 Bromma S-168 65 Sweden Tel: (46) 8-280-940 Fax: (46) 8-286-828 President/CEO: Lars Bondesson Research director: Goran Lindgren R&D expertise: Development and manufacture of bio-separation media Technological expertise: BA, P/S Principal products/instrumentation: Novarose® High Performance SE-media; Novarose® SE PrePac High Performance Prepacked SEcolumns; Novarose® ActHigh and ActLow High Performance Preactfvated Media; Novarose™ IDA, Novarose TREN and Novarose® DPA High Performance IMAC Media; Novaline® High Performance Columns.

Main products/instrumentation under R&D: Lactoperoxidase, lactoperrin, collagen, pancreatin.

1471

Add: 100, capitola Dr. #307 Durham, NC 27713 Tel: (919) 484-1429 Fax: (919) 484-1905 E-mail: [email protected] Web site: www.insectbio.com President/CEO: Dr. J. P. Bennett Research director: Dr. A. Brandt R&D expertise: Development and manufacture of safer, insecticides from a new proprietary platform technology. Technological expertise: E, Q, BA, C/TC, DD, PB, P/S, RD Main products/instrumentation under R&D: Larvacide/adultacide, pre-registration. Sealed and granted patents: 8 patents held.

1472 1470

INOVATECH

INSECT BIOTECHNOLOGY, INC.

INSIGHT BIOTECHNOLOGY LIMITED

Add: 31212 Peardonville Rd. Abbotsford, British Columbia V2T 6K8 Canada

Add: PO Box 520 Wembley, Middlesex HA9 7YN U.K.

Tel: (604) 857-9080

Tel: (44) 181-385-0303

Fax: (604) 857-2679

Fax: (44) 181-385-0302

President/CEO: J. Hugh Wiebe

E-mail: insight_biotechnology@compuserve. com

Research director: Ed Charter, Ph.D. R&D expertise: Research of isolation and purification of proteins from natural sources, products manufacture

President/CEO: John Rawlinson R&D expertise: Development and manufacture of cancer and Alzheimer’s research.

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Technological expertise: AE, F, PA, RD, C/TC, GA, H/CF, P/S

diseases associated with aging or autoimmune conditions.

Main products/instrumentation under R&D: Anticancer and Alzheimer’s biotech medicines.

Key sales market contracts: Santen Pharmaceuticals has rights in Japan to develop and market BetaKine for the treatment of macular holes; Genzyme Corp. — Development and commercialization of Betakine for tissue repair, MS and other systemic applications.

1473

INSIGHT STRATEGY & MARKETING, LTD.

Add: PO Box 2128 Rabin Science Park Rehovot 76121 Israel Tel: (972) 8-946-3032 Fax: (972) 8-946-1042 E-mail: [email protected] President/CEO: Dr. Nairn Tarnari Research director: Dr. Dror Melamed R&D expertise: R&D and manufacture biotechnology medicines/pharmaceuticals. R&D collaboration: Hadassah University Hospital, Jerusalem. Technological expertise: E, F, PA, CB, C/TC, GT, H/CF, P/S, RD Main products/instrumentation under R&D: ECM-modulation technologies: I-Recombinant human heparanase, preclinical; II-Heparanasebased diagnostics, preclinical. Sealed and granted patents: Recombinant human heparanase; heparanase-based diagnostic tools; heparanase bioactivity assays; heparanase neutralizing monoclonal antibodies.

1474

Key license and trade contracts: Genentech has cross licensing patent agreement with rights to Celtrix for certain recombinant process patents; Green Cross Corp. development and commercialization of SomatoKine for treatment of osteoporosis in Japan. Technological expertise: Q, RD, P/S, BA, C/TC, PMC, CH/S, SY, D-D, DD Principal products/instrumentation: IPLEXTM (mecasermin rinfabate [rDNA origin] injection), a combination of human insulin-like growth factor 1(rhGFBP-3) is approved by the FDA for the treatment of growth failure in children with severe primary IGF-1 deficiency. Main products/instrumentation under R&D: BetaKine for macular holes, macular degeneration and dermal ulcers — Phase I; BetaKine for corneal wounds, retinal edema, stimulate opthalmic tissue repair and reduce damage, speed and strengthen wound healing, MS and osteoporosis — preclinical testing; SomatoKine and TGF-beta receptors for opthalmic tissue repair and reduction of tissue damage, muscle wasting in pulmonary disease and osteoporosis — preclinical testing.

INSMED, INC. 1475

Add: 800 E. Leigh Street Ste. 206 Richmond, CA 23219

INSMED PHARMACEUTICALS, INC.

Tel: (804) 565-3000

Add: 800 E. Leigh St. Richmond, VA 23219

President/CEO: Dale A. Stringfellow, Ph.D.

Tel: (804) 828-6893

Research director: Andreas Sommer, Ph.D.

Fax: (804) 828-6894

R&D expertise: R&D, manufacture of biopharmaceutical human therapeutics for degenerative

E-mail: [email protected] Web site: www.insmed.com

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President/CEO: Geoffrey Allan, Ph.D. R&D expertise: Principal focus of INSMED is the development and manufacture of treatments, drugs for endocrine and metabolic diseases; R&D. Joint ventures: Han Pharmaceuticals. Key license and trade contracts: Taisho Pharmaceuticals, Genzyme. Technological expertise: CC, PA, SMC, CB Principal products/instrumentation: INSI-1, SOMATOKINE. Sealed and granted patents: Insulin mediator substance; method for producing chiroinositol; purified insulin mediators and purification process for same; dietary supplement for insulin-resistant diabetics; quantitative analysis for diabetic condition predictor involving chiroinositol; method for the production of D-chiroinositol; method of reducing elevated blood sugar in humans; quantitative analysis for diabetic condition predictor; immunossay for inositols.

1476

INSPIRAPLEX

Add: 3650 St. Urbain Montreal, PQ H2X 2P4 Canada Tel: (514) 843-2096 Fax: (514) 843-2098

expertise is focused on diseases leading to airway obstruction, acute respiratory failure, and environmental and occupational lung diseases. R&D collaboration: University of British Columbia, Alberta, Calgary, Saskatchewan, Manitoba, Toronto, Montreal, Laval, Sherbrooke, Queens, McMaster, Western Ontario, McGill, Dalhousie and hospitals. Technological expertise: SMC, AB, CH/S, D-D, GA, H/CF Principal products/instrumentation: Multidisciplinary expertise in chronic bronchitis, emphysema, asthma, cystic fibrosis, indoor air quality (home, offices and farm buildings), obstructive sleep apnea, chronic and acute respiratory failure. contract research/clinical trials products Subsidiary bodies: Head office Montreal Chest Instate, Research Centres: University of British Columbia, University of Alberta, University of Calgary, Centre for Agricultural Medicine — University of Saskatchewan, University of Manitoba, University of Western Ontario, University of Toronto, Hospital for Sick Children’s Research Institute, Mount Sinai Hospital, Toronto General Hospital Research Institute, The Research Institute of Queen Elizabeth Hospital, McMaster University, Queen’s University, McGill University, Universite de Montreal, Universite Laval, Universite de Sherbrooke, Dalhousie University.

E-mail: [email protected] Web site: www.cmc.ca/MIC/inspiraplex.html President/CEO: Dr. Peter Macklem Research director: Dr. Qutayba Hamid R&D expertise: Multidisciplinary expertise in diseases leading to airway obstruction and environmental/occupational lung diseases. A network of 70 investigators located in 18 research centers across Canada. A non-profit corporation primarily funded by the Medical Research Council under the federal Network of Centres of Excellence program. Research

1477

INSTITUTE FOR ANIMAL SCIENCE AND HEALTH (ID-DLO)

Add: Edelhertweg 15 P.O. Box 65 Lelystad NL-8200 AB The Netherlands Tel: (31) 320-238-238 Fax: (31) 320-238-050 E-mail: [email protected] Web site: www.id.dlo.nl

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President/CEO: Prof., Dr. C.J.G. Wensing

Tel: (613) 993-5975

Research director: Dr. Ph. van der Heijden

Fax: (613) 952-5136

R&D expertise: Fundamental and applied research in animal science and health; development, testing and production of vaccines and diagnostic tests.

E-mail: [email protected]

Technological expertise: E, PA, Q, C/TC, GA, H/CF, PB, RD

R&D expertise: Research and immunochemistry and in the cell biology of neurodegenerative diseases; therapeutic drug products development/manufacture, preclinical research.

Principal products/instrumentation: Vaccines, sensitines, diagnostic test kits, marker vaccines plus diagnostic tests, contract research and services.

1478

INSTITUTE FOR BIOLOGICAL RESEARCH AND DEVELOPMENT, INC. (IBRD)

Add: 2525 Campus Dr. Irvine, CA 92715 Tel: (714) 476-2727 Fax: (714) 752-7297 President/CEO: F, Richard Nichol, Ph.D. Research director: Sharon Anderson, M.S. R&D expertise: Full-service R&D of pharmaceutical and biotechnology product development company providing comprehensive drug development services; contract research organization. Technological expertise: AB, BS, CS, DH, G Main products/instrumentation under R&D: Contract biotech medicines. Subsidiary bodies: IBRD, 620 West Germantown Pike, Suite 270, Plymouth Meeting, PA 19462; ICCR, IBRD Center for Clinical Research, 105 Neptune Blvd., Neptune, NJ 07753; IBRD Japan, 3-12 Kioi-cho, Chiyodaku, Tokyo 102, Japan.

1479

INSTITUTE FOR BIOLOGICAL SCIENCES

Add: National Research Council of Canada 1200 Montreal Rd. Bldg. M-54 Ottawa, Ontario KlA OR6 Canada

Web site: www.nrc.ca/ibs President/CEO: Gabrielle Adams, Ph.D.

R&D collaboration: Service and collaboration agreements with industrial partners. Technological expertise: F, TE, Q, SY, CB, DD, BI, G, BA, RD, GA, H/CF, C/TC, AB, E, D-D Main products/instrumentation under R&D: Research on cell biology of neurodegenerative diseases: intracellular signal processing and second messengers; cell electropohysiology and intracellular calcium imaging; biochemical mechanisms of apoptosis; in vitro and in vivo disease models. Immunochemistry Research, structural analysis and chemistry of bacterial carbohydrate antigens and of cell adhesion molecules; carbohydrate-based therapeutics; chemistry and bacterial expression of peptide epitopes; antibody engineering for therapeutics and diagnostics; vaccine design for improved praentation of peptide and carbohydrate epitopes. Mass spectrometry, small-scale fermentation. Subsidiary bodies: Animal facility, 600 Mhz NMR, mass spectrometry, small scale fermentation.

1480

INSTITUTE FOR SCIENCE TRAINING AND RESEARCH, INC.

Add: 603 Stewart St., Suite 601 Seattle, WA 98101 Tel: (206) 748-9471 Fax: (206) 748-9472

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Web site: www.bioistr.com

324300; Qujiang Industrial Park, Zhejiang Province, Quzhou, 324000, P. R. China

President/CEO: Laurie Hassel

Tel: (86) 570-601-6697

R&D expertise: Biotechnology and biornformatics training courses.

Fax: (86) 570-304-1491

Technological expertise: Q, BI, CH/S, G, RD

Web site: http://kh.nj110.net

Principal products/instrumentation: Biotechnology for professionals; btoinforrnatics and computational biology; biotechnology for physicians; understanding biotechnology.

President/CEO: Yangfu Lin

E-mail: [email protected]

1481

INSTITUTE OF FOOD RESEARCH

Add: Norwich Research Park Norwich, Norfolk NR4 7UA U.K.

Colney

Tel: (44) 160-325-5000 Fax: (44) 160-350-7723 E-mail: [email protected] Web site: www.ifr.bbsrc.ac.uk President/CEO: Prof. A. Robertson Research director: Prof. A. Robertson R&D expertise: Research into food safety, nutrition and health, food quality, related products development and manufacture. R&D collaboration: British Technology Group. Technological expertise: GA, G, PMC, E, F, P/S, Q, SMC, AB, AF, BI, C/TC, COC, CH/S, R, RD Principal products/instrumentation: Contract research/clinical trials products, food processing, nutraceuticals, pesticide.

1482

INSTITUTE OF JIA QING BAZHEN WINE, KAIHUA COUNTY

Add: 4 Building 2 Qinnan, No. 6 Jefang Road, Chengnan Town, Kaihua County, Zhejiang,

E-mail: [email protected]

Research director: Lin Shan R&D expertise: Research in senility using traditional and modern advanced technique, development and production ofs traditional Chinese materia medica (TCMM), a secret prescription handed down in the family from generation to generation. Technological expertise: P/P, P/S, TCMM Key sales market contracts: Health Guide editorial department, medical ministry of Peking University. Principal products/instrumentation: Jia Qing Bazhen (eight precious ingredients medicated) wine, Guo Shijiang zi (Approval No.): G20040442, made from four classed traditional Chinese materia medica (invigorating Qi, invigorating Yang, enriching the blood, tonifyingnourishing Yin) and grain wine, is generally an invigorating wine. The medicated wine is brown and includes varied healthy effective components: 20 saponins, 11 flavonoids, 21 polysaccharides, 18 amino acids, vitamins A, B, C, E, and 11 microelements, etc. Flavonoids are commonly known for the potential bioactivities including antivirus, anti-oxidization, antimultidrug resistance and neuron protection, anti-reserved tumor cell multidrug resistance, enzyme inhibitor, hormone-like function, reducing and removing diabetic sequelae, etc; the polysaccharides possess unique functions as the immunomodulatory, anti-tumor activity, decreasing blood glucoses and lipids, antioxidant activity etc.; saponins showed a protection of hepatic cell from the fibrosis by inhibition of hepatic stellate cells activities and extracellular matrix synthesis, promoting apoptosis of

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hepatic stellate cells and degradation of extracellular matrix; microelements and vitamins are elements for keeping of human physiological function and for acceleration of human health. Jia Qing Bazhen medicated wine can dispel senile plaques, improve senility, dysmenorrhea, fatigues in body and mind by invigorating the spleen to repleniching qi. Main products/instrumentation under R&D: Cosmetic, Jia Qing cold cream.

1483

INSTITUTE OF MEDICINAL PLANT DEVELOPMENT, CHINESE ACADEMY OF MEDICAL SCIENCES & PEKING UNION MEDICAL COLLEGE

Add: No. 151, Malianwa North Road, Haidian District, Beijing 100094, P. R. China Tel: (86) 10-6289-6288 Fax: (86) 10-6289-9715

461

Medicine Resources, The National Medicinal Plant Gene Bank, The Laboratory for Investigation into the Chemical Basis and Resource. Main products/instrumentation under R&D: Research into medicinal plant resources protection and the pharmaphylogeny of important medicinal plant group in China, a model project using wild crafting techniques to commercialize Fritillaria cirrhosa (chuan bei mu), an endangered biological resource in western China, Center for Chinese Herbal Therapy (CHT) for Asthma. Projects: Chemical and Biological Characteristics of Botanicals, Technology R&D platform for prevention and control of pest and disease affecting Chinese medicinal herbs, Research and delineation of quality standards and control protocols for the seeds of 20 species of Chinese medicinal herbs, medicinal plant cultivation, natural drug product chemistry, etc. R&D cooperation unit: Harvard University and Royal Botanical Garden, Kew in U.K.

E-mail: [email protected] Web site: http://www. implad.ac.cn

1484

President/CEO: Chen Shilin

INSTITUTO NACIONAL DE INVESTIGACIONES FORESTALES Y AGROPECUARIAS

Research director: Xiao Peigen R&D expertise: Protection, research, development and utilization of medicinal plant resources by means of modern scientific technologies, preserving the germplasm resources of Chinese medicinal plants, protecting rare and endangered species, developing and implementing policies seen in the Good Agricultural Practice (GAP), researching reference standards for TCMM and conducting surveys of medicinal herb resources.

Add: kM 24.5 Carretera Zacatecas-Fresnillo Zacatecas, Zacetecas Mexico

Technological expertise: TCMM, GB, CMH, CHT

Principal products/instrumentation: Agriculture, biologicals, biotherapeutics

Principal products/instrumentation: Pharmacophylogenetics, specializing in Gastrodia (tian ma), American Ginseng, Amomi (sha ren) and Mucade (rou dou kou); international and national TCM R&D base including Engineering Research Center of Chinese Traditional

Tel: (52) 9-850-199 Fax: (52) 9-850-363 President/CEO: Sanchez

Ing.

Gmllermo Acosta

R&D expertise: R&D of biotherapeutics Technological expertise: T,C/TC, G

1485

INSTITUT PASTEUR — TEXCELL

Add: 25, Rue du Docteur Roux Paris 75724 Cedex 15 France

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Tel: (33) 145-688-435 Fax: (33) 145-688-859 E-mail: [email protected] Web site: www.pasteur.fr/bio/rar/texcell.html President: Daniel Larzul, Ph.D. Research director: Daniel Larzul, Ph.D. R&D expertise: Biomedical drug and equipment research, products manufacture Technological expertise: P/S, BA, C/TC, GA, GT, HTDS Main products/instrumentation under R&D: HIV 1, HIV 2, HBV, Probes.

1486

INSTITUT ROSELL-LALLEMAND

Add: 8480 Boul. St-Laurent Montreal, Quebec H2P 2M6 Canada Tel: (514) 381-5631 Fax: (514) 383-4493 E-mail: [email protected] President/CEO: DuPuis Angers Research director: Dr. Jacques Goulet R&D expertise: Development of fermentation technology, related dairy and food products manufacture. R&D collaboration: Tom Tompkins. Technological expertise: F Principal products/instrumentation: Cultures of lactic bacteria for dairy and food products, probiotics, nitrogen fixing bacteria, Probioticsfermerits, acidophilus-bifidobacteria. Subsidiary bodies: Lallemand France, U.S.A. and Mexico. Sealed and granted patents: Patents pending: PROBIOCAF, shelf stability.

1487

INSTRUMENTS FOR RESEARCH AND INDUSTRY, INC.

Add: 108 Franklin Ave. Cheltenham, PA 19012

Tel: (215) 379-3333 Fax: (215) 663-8847 E-mail: [email protected] Web site: www.I-2-r.com President/CEO: J. Werkman R&D expertise: Development and manufacturers of instruments and equipment used in R&D labs. Technological expertise: PMC, SY Principal products/instrumentation: Temperature and vacuum controllers, GLOVE BAG inflatable glove chambers, safety shielding, liquid level and water flow monitors, light boxes, gamma radiation shielding, LEAD DONUT and LEAD CUFF Stabilizers.

1488

INSTRUMENTS, SA. JY/SPEX

Add: 3880 Park Ave. Edison, NJ 08820 Tel: (732) 494-8660 Fax: (732) 549-5157 E-mail: [email protected] Web site: www.isainc.com President/CEO: Neil Stein R&D expertise: Spectroscopy research and light measurement. Development, products manufacture. Technological expertise: CH/S, PMC Principal products/instrumentation: Fluorology and FluoroMax Spectro-fluorometers, ICP Emission spectrometers, Raman instruments plus optical spectrometers, CCO’s and light measurement equipment, contract manufacturing products. Main products/instrumentation under R&D: Microwell plate readers. Sealed and granted patents: UV and sunscreen evaluation.

1489

INTEG, N.A., INC.

Add: 1321 Lakeshore Dr. Irving, TX 75060

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1491

463

INTEGRA LIFESCIENCES CORPORATION

E-mail: [email protected] Web site: www.integ-na.com

Add: 105 Morgan Lane Plainsboro, NJ 08536

President/CEO: Jerry Skotak

Tel: (609) 275-0500

Research director: Ralph Baldwin

Fax: (609) 799-3297

R&D collaboration: Hewlett-Packard Channel Partner.

Web site: www.Integra-LS.com

Technological expertise: CH/S, PMC

Research director: Michael Pierschbacher, Ph.D.

Principal products/instrumentation: Instrument interfacing, data acquisition, instrument control, LIMS consulting, chromatographic data validations, custom programming.

1490

INTEGRA BIOSCIENCES AG

Add: Industriestrasse 44 Wallisellen CH-8304 Switzerland Tel: (41) 1-877-4646 Fax: (41) 1-877-4600 E-mail: [email protected] Web site: www.integra-biosciences.com President: CEO: Thomas Muelles Research director: Thomas Pillich R&D expertise: Research of microbiology, molecular biology, cell culture, liquid handling, products development. Principal products/instrumentation: Media preparator, petri dish filler, automatic bunsen burner, loop sterilizer, automatic dosing pump, autoclaves/sterilizer, CO2, incubator, hoods for cell culture, automatic pipettors/ hand held, bioreactor hollow fiber, spinner/ roller systems, instruments for nucleic acid sequencing, fermenters, automatic pipetting units. Subsidiary bodies: Fernwald; GaubonneCedex; Hertfordshire U.K.; Lowell, U.S.A.; Fernwald Paris; London, U.K.; Washington, DC, U.S.A.

President/CEO: Stuart M. Essig

R&D expertise: Integra Development and manufacture of implantable medical and biopharmaceutical therapies that target and control cellular behavior. R&D collaboration: Johnson & Johnson Professional, Inc. (cartilage). Rutgers University, University Hospital (Copenhagen), Genetics Institute (Sofamor/Danek). Key sales market contracts: Johnson & Johnson Professional, Inc. Sulzer Caldteck, Arrow, Bard, Quintan. Key license and trade contracts: M.I.T., Bumham Institute (extracellular matrix), Cambridge Antibody Technology, University of Medicine and Dentistry of New Jersey. Technological expertise: DD, P/S, PG, SMC, TE Principal products/instrumentation: INTEGRA artificial skin, INTEGRA™; Hemostat, HELISTAT; Hemostat (control bleeding), HELISTAT MFC; BIOMEND absorbable collagen membrane, BIOMEND; contract manufacturing, contract research/clinical trials products, organ transplants/culture. Main products/instrumentation under R&D: Cartilage Regeneration Matrix, preclinical; Peripheral Nerve Conduit, Phase II; 2nd Generation INTEGRA Artificial Skin, preclinical; DuraGen, pending approval. Subsidiary bodies: Corporate Research Center, San Diego, CA.

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Sealed and granted patents: Integra owned or had exclusive rights to 134 issued or allowed U.S. patents.

1492

INTEGRATED BIOMOLECULE CORPORATION

1493

INTEGRATED DNA TECHNOLOGIES, INC.

Add: 1710 Commercial Park Coralville, LA 52241 Tel: (319) 626-8400 Fax: (319) 626-8444

Add: 9030 South Rita Rd. No. 100 Tucson, AZ 85747-9108 Tel: (520) 799-7566

E-mail: [email protected] Web site: www.idtdna.com

Fax: (520) 799-7562

President/CEO: Joseph A. Walder, M.D., Ph.D.

E-mail: [email protected]

Research director: Mark behlke, M.D., Ph.D.

Web site: www.integrated.com

R&D expertise: Production of oligonucleotides; development and manufacture of new oligonudeoride analogs for diagnostic and therapeutic use.

President/CEO: Robert S. Green Research director: Dinesh Patel, Ph.D. R&D expertise: Development and manufacture of fine synthetic organic compounds for the pharmaceutical, diagnostic, clinical laboratory and nutritional industries, induding peptides, carbohydrates and enzyme substrates; development of nutritional supplements. Joint ventures: With various biotech, pharmaceutical and nutritional companies. R&D collaboration: With various biotech, pharmaceutical and nutritional companies. Technological expertise: CH/S, PB, P/S, SMC, SY, CB Principal products/instrumentation: Fine synthetic organic compounds, including peptides, carbohydrates and enzyme substrates; production under GMP; nutritional supplements. Main products/instrumentation under R&D: Custom pharmaceutical grade peptides; novel peptide chemistries; novel peptide synthesis hardware and software, custom carbohydrates and enzyme substrates, novel nutritional products. Sealed and granted patents: Several patents pending.

Key sales market contracts: Lorin Gassel, Ph.D. Technological expertise: F, Q, E, RD, P/S, C/TC, CH/S, SY, D-D, AB, GT, G Principal products/instrumentation: Custom synthesis of oligonucleotides, 3′-ribose primers, chimeric antisense oligonudeotides, RNA, Gene, Spedality; RNA Transduction Delivery System: Transductin™ is a peptidebased double-stranded RNA (dsRNA) transduction delivery system for research applications. The system is intended for in vitro testing and high-throughput screening projects. Transductin complexes with dsRNAs (such as siRNAs) and delivers them across cell membranes via macropinocytosis, 2009. Main products/instrumentation under R&D: Antisense oligonudeotides.

1494

INTEGRATED SEPARATIONS SYSTEMS, DIVISION OF ENPROTECH

Add: 55 Heritage Ave. Portsmouth, NH 03801 Tel: (800) 433-6433

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465

INTEGRIDERM, INC.

President/CEO: Stanley Klein R&D expertise: R&D, manufacture of for protein and molecular biology separations products for biotechnology, pharmaceutical and academic research markets.

Add: 2700 Memorial Parkway SW Huntsville, AL 35801

Key sales market contracts: Biorobotics, U.K.; Kurabo Industries.

E-mail: [email protected]

Key license and trade contracts: Genetics Institute.

CEO: Thomas P. Dooley, Ph.D.

Technological expertise: P/S, PP, AT, P/PS, PC Principal products/instrumentation: Sepragels; rniniplus gels; Dai-ichi silver stain; Autogen 540 & 740,1993,155 Mini, Mini Plus Gels, Autogen 740, Nal000, 850. Main products/instrumentation under R&D: Biopicker.

Tel: (800) 500-4129 Fax: (800) 500-6439 Web site: www.integriderm.com Research director: Emie Curto, Ph.D. R&D expertise: Genomic research and biopharmaceutical development and related products in the skincare and dermatology industry. R&D collaboration: Research Genetics, INC. Invitrogen Corp. Key sales market contracts: Altruis LLC and the Altruis Biomedical Network. Technological expertise: BI, C/TC, COC, D-D, GA, G, PG, E, R, Q, SMC, RD

1495

INTEGRATED TECHNOLOGIES, LTD.

Add: Viking House, Ellingham Way Ashford, Kent TN23 6NF U.K. Tel: (44) 123-363-8383 Fax: (44) 123-363-9401 E-mail: [email protected]

Principal products/instrumentation: DNA microarray for dermatology, Derm Array™. Main products/instrumentation under R&D: DNA microarray for pharmacology/toxicology, ; Active ingredients for topical skin lighteners, preclinical development. Sealed and granted patents: Pending for DNA microarrays and topical skin lighteners.

Web site: http://[email protected] President/CEO: Arnir Modjarrad

1497

INTELLIGENE

Research director: Dean Forster R&D expertise: Contract design, development and manufacture of analytical instrumentation. Joint ventures: Array Medical, NJ, U.S.A.; Piezoptic, U.K..

Add: Macan Building, 8 OM Veolano, Givat Shaul POB 35241 Jerusalem 91351 Israel Tel: (972) 2-654-0333 Fax: (972) 2-654-0222

Technological expertise: R, CH/S, CW, BME

E-mail: [email protected]

Principal products/instrumentation: Contract manufacturing products, analytical instruments.

President/CEO: Dr. James Richards Research director: Asher Nathan

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R&D expertise: Development of new platform technology for diagnostics, related products manufacture. Key license and trade contracts: RPI, INC. Technological expertise: E, COC, GA Main products/instrumentation under R&D: Preclinical diagnostic testing kit. Sealed and granted patents: 6 patent applications.

1498

INTELLIGENE EXPRESSIONS, INC.

Add: 1938-94 St. Edmonton, Alberta TGN 1J3 Canada Tel: (780) 438-5722 Fax: (780) 430-1529

Web site: www.intelligen.com President/CEO: Dr. Dernetri Petrides Research director: John Calandranis R&D expertise: R&D, manufacture bioprocess engineering products; simulation and design tools for the biochemical, pharmaceutical, food, and environmental industries. R&D collaboration: MIT. Key license and trade contracts: MIT. Technological expertise: E, F, C/TC, PMC, LP, RD, CH/S Principal products/instrumentation: BioPro Designer; Enviro-Pro Designer; SuperPro Designer; BatchPro Designer.

1500

INTERACTIVA BIOTECHNOLOGY, GMBH

E-mail: [email protected] Web site: www.intelligene.com President/CEO: Fahar Merchant, Ph.D. R&D expertise: Research of process development, optimization, scale-up, validation and cGMP clinical manufacturing of fermentation derived biologies.

Add: Sedanstrasse 10 ULM, Baden-Wurtemberg D-89077 Germany Tel: (49) 731-9357-9290 Fax: (49) 731-9357-9291 E-mail: [email protected] Web site: www.interactiva.de

Technological expertise: F, P/S, BA, DD, PMC

President/CEO: Mark Eboon

Main products/instrumentation under R&D: Clone selection and fermentation optimization; development of validatable purification processes; assay development and method validation, fermentation, recovery and purification scale-up.

R&D expertise: Research of production of synthetic oligonucleotides and peptides, contract research in nucleic acids.peptide instrumentation

Research director: J. F. Ramalho Ortigao

Joint ventures: Stratec, Gatc, Hybaid R&D collaboration: Paul Hartmann AG, University of Uppsala, DKFZ. Key sales market contracts: GATC, Hybaid.

1499

INTELLIGEN, INC.

Add: 2326 Morse Ave. Scotch Plains, NJ 07076 Tel: (908) 654-0088 Fax: (908) 654-3866 E-mail: [email protected]

Key license and trade contracts: Paul Hartmann AG. Technological expertise: CS, PI, PB, PS, SI, SY Principal products/instrumentation: Custom directed synthesis and design of complex peptides. Oligonucleotides and oligopeptides, biochips, SNP, gene synthesis, peptides.

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Main products/instrumentation under R&D: XNA on gold biochips.

Web site: www.interbio.com

Subsidiary bodies: France, Sweden.

Research director: Dr. Cayce Warf

Sealed and granted patents: XNA on gold, Snips on gold.

R&D expertise: Development manufacture and sales of microbial products for applied environmental biotechnology.

1501

INTER-AMERICAN RESEARCH ASSOCIATES, INC.

Add: 18919 Premiere Ct. Gaithersburg, MD 20879 Tel: (301) 926-0713 Fax: (301) 926-1348 President/CEO: Thomas P. Kelly, Jr.

President/CEO: J. Peter Perez

Technological expertise: E, BA Principal products/instrumentation: MicroPro line of wastewater treatment products; McFree, Drain line products for McDonald’s Fast Food chain. Subsidiary bodies: Houston, TX — production and sales; Dublin, Ireland — production and sales; Aubagne, France — production and sales.

Research director: Daniel J. Hill R&D expertise: Development and production of highly purified biologicals and custom serum products for use in research or diagnostic application. Technological expertise: PA, T, BA, C/TC, P/S Principal products/instrumentation: Purified plasma proteins, albumin, AFP, CRP, immunoglobulins, CA125, CA199, CA72-4, human NSE, clinically significant plasma, monoclonal and polyclonal antibodies, unique tissue/cell culture supplements, cholic acid, custom prepared plasma products and custom, contract product development and production, purified human transferrin. Main products/instrumentation under R&D: Transgenic proteins, human derived serum substitute.

1503

INTERCARDIA RESEARCH LABORATORIES

Add: 8 Cedar Brook Dr. Cranbury.NJ 08512 Tel: (609) 655-6900 Fax: (609) 655-6930 Web site: www.transcell.com President/CEO: Clayton I. Duncan Research director: Helena R. Axelrod R&D expertise: Research of carbohydrate combinational chemistry for anti-infectives drug discovery. Related anti-infective drug development and manufacture. R&D collaboration: Merck & Co., antibacterials. Technological expertise: CB, COC, DD, D-D, GA, HTDS, R, SY

1502

INTERBIO

Add: 9200 New Trails Dr. The Woodlands, TX 77381 Tel: (504) 293-2033 Fax: (504) 292-6665 E-mail: [email protected]

Main products/instrumentation under R&D: Drug and DNA delivery systems. anti-infective drug

1504

INTERCELL, LLC.

Add: Dr. Bohr-gasse 7B Vienna 1030 Austria

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Tel: (43) 1-796-4422

Tel: (503) 684-8008

Fax: (43) 1-796-4422

Fax: (503) 684-9559

Web site: www.intercell.co.at

E-mail: [email protected]

President/CEO: Dr. Alexander von Gabain

President/CEO: Ingeborg A. Vaden

Research director: Dr. Michael Buschle; Dr. Walter Schmidt

Research director: James Goodwin, Ph.D.

R&D expertise: Development and manufacture of treatment drugs and diagnostics for infectious diseases and cancer. R&D collaboration: TIGR; Vienna BioCenter; Lund University, Sweden; Karolinska Institute, Sweden; University of Munich and Freiburg; Ludwig Institute. Key license and trade contracts: Boehringer Ingelheim. Technological expertise: P/S, C/TC, DD, HTDS, PB Principal products/intrumentation: Contract manufacturing products, diagnostics, vaccines

1505

INTERCHIM

R&D expertise: Development and manufacture of bioprocess engineering products; manufacture and characterization of organic polymer microspheres (latexes) for use in medical diagnostics industry. Technological expertise: LP, P/S, PMC, SY Principal products/instrumentation: Ultraclean surfactant free latexes in various sizes and surface chemistries, fluorescent and colored latexes, protein coated latexes, specialty chemicals.

1507

INTERFERON SCIENCES, INC.

Add: 783 Jersey Ave. New Brunswick, NJ 08901 Tel: (732) 249-3250

Add: 213, Ave. J.F. Kennedy BP 1140 Montlucon 03103 France

Fax: (732) 249-6895

Tel: (33) 470-038-855

Web site: www.interferonsciences.com

Fax: (33) 470-038-260

President/CEO: Stanley G. Schutzbank, Ph.D.

E-mail: [email protected]

Research director: Mei-June Liao

President/CEO: Jean Christian Boch

R&D expertise: Development and manufacture of natural-source Alpha Interferon.

R&D expertise: Research and development in biologicals, and chromatography; products manufacture. Technological expertise: E, RD, P/S, GA, H/CF, SY Principal products/intrumentation: Reagents, contract development products.

E-mail: [email protected]

Key sales market contracts: Industria Farmaceutica Andromaco, Mexico; Cell Pharm, Germany. Key license and trade contracts: HoffmannLa Roche. Markets: Biologicals, pharmaceuticals Technological expertise: C/TC, CS, FE

INTERFACIAL DYNAMICS CORP.

Principal products/instrumentation: Alferon N injection.

Add: Suite 120 17300 SW Upper Boones Ferry Rd. Portland, OR 97007

Main products/instrumentation under R&D: Alferon N Injection — Hepatitis C, Phase III,

1506

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HIV infection — Phase III; Alferon LDO — HIV infection — Phase III; Alferon Gel.

1508

INTERGEN COMPANY (EUROPE)

Add: The Magdalen Centre Oxford Science Park Oxford 0X4 4GA U.K. Tel: (44) 1865-784-647 Fax: (44) 1865-784-648 E-mail: [email protected] President/CEO: Robert Beckman Research director: Dr. Edward Chait R&D expertise: R&D: enabling raw materials, cell and tissue culture; related products manufacture. Technological expertise: BS, E, RD, Q, SMC, HTDS, BA, C/TC, LP, P/S Principal products/instrumentation: Human Sera of all types. Chromogens base matrices, albumin, antigens, recombinent protein, contract manufacture products, sequencing.

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Principal products/instrumentation: Bovuminar Bovine Albumins (powder and solutions), Seracon Defibrinated Human Plasma, True Human Serum, Disease Screened Plasma/Serum and Specialty Biologics, Chromogenic Substrates, Growth Factors, Cytokines, Cytokine ELISA Kits, Rehatuin Fetal Bovine Serum, Aprotinin, Transferrin, Insulin, Trypsin, Gene Methylathor, Phycobiliproteins, Chromogens, Telornerase, Apoptosis kits and reagents, PCR and Quantitative PCR. Main products/instrumentation under R&D: Diagnostic manufacturing and research reagents, chemiluminescence, fluorescence, detection products and systems, Amplifloor SNP detection kits, Cell Viability Asssay CaspaTag Caspase Activity Kits.

1510

INTERGLASS, INC.

Add: 461 Haitian Rd. Woodbridge, ON L4L 3T1 Canada Tel: (905) 851-5170 Fax: (905) 851-3051

1509

INTERGIN COMPANY

Add: Two Manhattanville Rd. Purchase, NY 10577 Tel: (914) 694-1700 Fax: (914) 694-1429 Web site: www.intergenco.com President/CEO: Robert J. Beckman

E-mail: [email protected] President/CEO: Ian Kerr R&D expertise: Development and manufacture of laboratory glassware. Technological expertise: BME, SI Principal products/instrumentation: Laboratory glassware: ampoules serum vials, screw thread vials and tubes.

Research director: Edward M. Chait, Ph.D. R&D expertise: Cell and tissue culture research, biochemicals and reagents used in the manufacture of diagnostics, biopharmaceuticals and life science research. Key sales market contracts: International Reagents Corp., Sekisui Chemical Co., Novo Nordisk. Technological expertise: PA, P/S, BA, BS, C/TC

1511

INTERNATIONAL BIOIMMUNE SYSTEM

Add: 225 Community Dr., Ste. 140 Great Neck, NY 11021-5505 Tel: (516) 773-8255 Fax: (516) 773-8258 E-mail: [email protected]

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President/CEO: Myron Arlen

President/CEO: Granger Haugh

Research director: Olga Saric

Research director: Larry Beaty

R&D expertise: Development/manufacture of tissue crossreactivity/safety toxicology, testing of antibodies, antibody marketing.

R&D expertise: Development and manufacture of bulk biomaterials and OEM products for diagnostic and biotechnology industries.

Key license and trade contracts: Purdue Pharma.

R&D collaboration: Veritas Corp.

Technological expertise: H/CF, C/TC, PMC Principal products/instrumentation: Monoclonals, PCA 31.1, PCA 33.28. Main products/instrumentation under R&D: Immunogold staining kits. Sealed and granted patents: 1 issued; MAB’s against colon cancer, 6 filed.

1512

INTERNATIONAL CRYOGENICS, INC.

Add: 189 Townsend St. Birmingham, MI 48009 Tel: (248) 644-5822 Fax: (248) 644-1497

Key sales market contracts: Aalto Bio Reagents Ltd., International Bioscience, Inc. Shin Won Scientific Co., Veritas Corp, Technological expertise: E, PA, P/S Principal products/instrumentation: Ultra pure avidin, tumor markers, viral antigens, human and mammalian enzymes and serum proteins, calibrators, serum controls, and polyclonal antiserum. Main products/instrumentation under R&D: Hepatitis ad and ay antigens, polyclonal and monoclonal antibodies, infectious disease kits. Subsidiary bodies: San Marcos, CA 92069.

1514

INTERNATIONAL IMMUNOLOGY CORP.

President/CEO: Mary Ann Brown Research director: Ruth Swarin

Add: 25549 Adams Ave. Murrieta, CA 92562

R&D expertise: Andrology studies and sperm banking. Primary business service company.

Tel: (909) 677-5629

Technological expertise: BA, CH/S

President/CEO: Katsuhiro Kataysma

Main products/instrumentation under R&D: Clinical tests program

Research director: Randolph Dickinson

1513

INTERNATIONAL ENZYMES, INC.

Add: 1432-B South Mission Rd. Fallbrook, CA 92028 Tel: (760) 728-5205 Fax: (760) 728-2902 E-mail: [email protected] Web site: www.internationalenzymes.com

Fax: (909) 677-6752

R&D expertise: R&D and manufacture of bioprocess engineering products; manufacture and distribution of bulk polyclonal antisera/human serum calibrators for further manufacture. Technological expertise: PA, P/S, BA, CH/S, RD, LP Principal products/instrumentation: Goat antisera/antibodies for human immunoglobulins, human serum proteins, human apolipoproteins, cardise markers; human-based serum calibrators/controls for the above. Contract manufacturing, products

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Main products/instrumentation under R&D: OEM reagent bulk manufacturing.

1515

INTERNATIONAL ISOTOPES, INC.

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Principal products/instrumentation: Pregnancy tests, ovulation tests, hepatitis tests, tumor marker tests, etc.

1517

INTERNATIONALPBI

Add: 1500 Spencer Rd Denton, TX 76205

Add: Via Novara 89 Milano 20153 Italy

Tel: (940) 484-9492

Tel: (39) 2-4877-9245

Fax: (940) 483-0431

Fax: (39) 2-4009-0010

E-mail: [email protected]

E-mail: [email protected]

Web site: www.internationalisotopes.com

President: Elio Ligugnana Contacts

President/CEO: David Camp, Ph.D.

R&D expertise: Development and products manufacture of Microbiology Testing Systems.

Research director: Marcus J. Miller R&D expertise: Development and manufacture of radiochemicals, contract manufacturer of medical devices and radiopharmaceuticals. Key sales market contracts: Imagyn Medical, Bracco Diagnostics, Neorx Corporation. Technological expertise: PMC, P/S, R Principal products/instrumentation: I-125 Brachytherapy seeds, I-123, contract manufacturing products, IL-201.

Technological expertise: C/TC Main products/instrumentation under R&D: Microbiology testing system.

1518

INTERNATIONAL PORTLAND CORP.

Add: Beaverton, OR 97007 Tel: (503) 648-1504 Fax: (503) 648-4235

1516

INTERNATIONAL NEWTECH DEVELOPMENT, INC.

Add: 1629 Fosters Way Delta, BC V3M 6S7 Canada Tel: (604) 522-1619

President/CEO: Leon Orchard R&D expertise: Development and manufacture of clean room manufacturing.products. Technological expertise: BME, SI Principal products/instrumentation: Portable class 10 clean stations.

Fax: (604) 522-6331 E-mail: [email protected] Web site: www.ind.ca

1519

INTERNEURON PHARMACEUTICALS, INC.

President/CEO: Johnny Yau Research director: Johnny Yau R&D expertise: Research products manufacture of Medical diagnostic tests. Technological expertise: PA, Q, C/TC, CH/S, GA, H/CF, PB, P/S, RD, SY

Add: 99 Hayden Ave., Suite 200 Lexington, MA 02421-7966 Tel: (781) 861-8444 Fax: (781) 861-3880 Web site: www.interneuron.com

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President/CEO: Glenn L. Cooper, M.D.

R&D collaboration: ACGT Laboratories.

Research director: Bobby Sandage, Ph.D.

Key sales market contracts: Over 30 manufacturers worldwide.

R&D expertise: Research of neurological and behavioral; related products development, related products development. Technological expertise: D-D, DD Main products/instrumentation under R&D: Citicoline (for stroke), Phase III, Pagodone (for anxiety), Phase III; SP501 Liver Disease, Phase III.

1520

INTERPHARM LABORATORIES, LTD.

Technological expertise: Q, GA, E, HTDS, P/S, RD Principal products/instrumentation: Cloneppete, Safe-Scint. contract manufacturing, contract research/clinical trials products in vitro toxicology testing method. Main products/instrumentation under R&D: Electrophoresis apparatus, lab safety product.

1522

INTERSEP, LTD.

Add: Science-Based Industrial Park Kiryat Weizmann Ness Ziona 76110 Israel

Add: Brook House Molly Millars Bridge Wokingham, Berkshire RG41 2WY U.K.

Tel: (972) 8-382-424

Tel: (44) 1189-795-566

Fax: (972) 8-407-566

Fax: (44) 1189-795-186

President: Alex Kotzer

E-mail: [email protected]

R&D expertise: Development and production of cytokines.

President/CEO: Paul Reardon

Technological expertise: C/TC, BS, RD

R&D expertise: Diagnostics, R&D and manufacture.

Principal products/instrumentation: Sytakines.

Research director: Paul Reardon

Technological expertise: PA, P/S, BA 1521

INTERSCIENCES, INC.

Add: 169 Idema Rd. Markham, ON L3R 1A9 Canada Tel: (905) 940-1831

Principal products/instrumentation: PARASEP; RAPYD TEST. Sealed and granted patents: PARASEP.

1523

INTERSPEX PRODUCTS, INC.

Fax: (905) 940-1832 E-mail: [email protected] Web site: www.interscience.com President/CEO: Leon G. Guluzian Research director: Ram Ramcharran R&D expertise: Development and manufacture of biotechnology products and pharmaceutical testing. Joint ventures: Amsco Canada, ACGT, Chemlab Services, Northam Labs, Bioshop Canada.

Add: 2030 Pioneer Ct, Ste. 4 San Mateo, CA 94403-1738 Tel: (650) 570-4337 Fax: (650) 570-5215 E-mail: [email protected] Web site: www.interspex.com/interspex President/CEO: Bhav P. Sharma, Ph.D. R&D expertise: Worldwide supply of enzymes and other specialty chemicals and biochemicals.

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Technological expertise: E, F, BA, C/TC, P/S, RD, SY Principal products/instrumentation: Specialty enzymes, biochemicals and chemicals for R&D and manufacturing.

1524

INTRABIOTICS PHARMACEUTICALS, INC.

Add: 1255 Terra Bella Rd. Mountain View, CA 94043

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Principal products/instrumentation: Viral diagnostic kits, virocidin, virocin, virogen herpes slide test, recombinant viral proteins and CD4/CD8 monitoring kit. Main products/instrumentation under R&D: Rapid HIV test available for export, virogen rotatest, gene therapeutic program, viral diseases and transplantation/cancer therapeutics, HIV-neutralizing antibodies, respiratory syncytial virus immune globulin. Subsidiary bodies: Rockville, MD, U.S.A.; Richmond, BC, Canada.

Tel: (650) 526-6800 E-mail: [email protected]

1526

President/CEO: Kenneth J. Kelley Research director: John C. Fiddes R&D expertise: Development and manufacture of antimicrobial pharmaceuticals. Technological expertise: PIS, AF, D-D Principal products/instrumentation: Contract antimicrobial

INTRACELLULAR IMAGING, INC.

Add: 1776 Mentor Ave. Cincinnati, OH 45212 Tel: (513) 351-4260 Fax: (513) 351-4380 E-mail: [email protected] Web site: www.intracellular.com President/CEO: Dr. Eric Gruenstein Research director: Jesus Luna

1525

INTRACEL CORR./BARTELS, INC.

Add: 2005 NW Sammamish Rd., Ste. 107 fssaquah, WA 98027 Tel: (425) 391-9005 Fax: (425) 392-4362 E-mail: [email protected] Web site: www.intracel.com President/CEO: Persis Strong Research director: Bryan Butman R&D expertise: Development and manufacture of viral products, including HIV-neutralizing antibodies, respiratory syncytial virus immune globulin etc., for scientific research, diagnosis and therapy. Technological expertise: PA, Q, C/TC, GA, P/S, RD

R&D expertise: Development, design and manufacture of fluorescence imaging and photometry systems. Epifluorescence/epiilluminating modules for microscopes. Technological expertise: C/TC, SH/S, FL Principal products/instrumentation: Incyt line of imaging and photometry systems, fluorescence immunoassay, Groony Epifluorescence retrofits for inverted and upright microscopes, mononucleotide polymorphic gene typing. Main products/instrumentation under R&D: Fluorescence imaging and photometry systems, Epifluorescence microscopes, epi-illuminating microscopes

1527

INTROGENE

Add: Wassenaarseneweg 72 Leiden 2333 AL The Netherlands

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Tel: (31) 71-524-8703

Web site: www.Introgen.com

Fax: (31) 71-524-8704

President/CEO: David G. Nance

E-mail: [email protected]

Research director: Deborah Wilson, Ph.D., J.D

Web site: www.introgene.com President/CEO: Dinko Valerio Research director: Dinko Valerio R&D expertise: Development and manufacture of biotechnology medicine products. Joint ventures: Galapagos Genomics; joint venture with Tibotec, Belgium. R&D collaboration: Flanders Interuniversity Institute for Biotechnology, Belgium. Key sales market contracts: JRH Biosciences for Per.c6 technology. Key license and trade contracts: Merck, Glaxo Wellcome, Novartis, Warner-Lambert, Rhone-Poulenc Rorer, Schering, Genzyme, Cobra Therapeutics. Technological expertise: R, RD, C/TC, GT, G Principal products/instrumentation: Adenoviral packaging cell line, Adenoviral adaptor construct, contract manufacturing products, contract research/clinical trial products. Main products/instrumentation under R&D: Adeno No 53, preclinical; Adeno ATF-BPTI, preclinical; Adeno IL-3, preclinical; ING N201, gene therapy for treatment of cancer, Phase II/III; IL-3 for gene therapy, preclinical; ATF-BPT1 for gene therapy, preclinical. Sealed and granted patents: Numbers for gene therapy, IL-3 for gene therapy; ATF-BPTI for gene therapy; gene manufacturing facilities.

1528

INTROGEN THERAPEUTICS

Add: 301 Congress Ave. Suite 1850 Austin, TX 78701 Tel: (512) 708-9310

R&D expertise: Research, development and related products manufacture of gene therapy (in vivo) for cancer or genetic disease. R&D collaboration: Aventis Key sales market contracts: Aventis Key license and trade contracts: University of Texas System, Sidney Kimmel Cancer Center, John Hopkins, Stanford, University of Pittsburgh Cancer Institute. Technological expertise: F, GT, GA, AB, BA, C/TC, Q, T, CH/S, DD, D-D, R, SMC, SY Principal products/instrumentation: INGN201 (Adp53), gene therapy, treatment of headcolli contract manufacturing products, contract research/clinical trial products, in vitro toxicology testing method. Main products/instrumentation under R&D: Various gene therapies for cancer in Phase I/IIa and Phase II/III; Advexin, Phase III, 2008; adenovirus p53 (gene therapy) for treatment of bladder, breast, lung, ovarian cancers, glioma, Phase II; ING N201 (adenovirus-p53), gene therapy, for treatment of head and neck cancer, prostate cancer, Phase III/IV. Subsidiary bodies: Clinical Support Laboratory. Sealed and granted patents: p53 gene in combination with DNA damaging agents (~ 2001); method for the production and purification of adenoviral vectors. 7, 125, 706, U.S.; formulation of adenovirus for gene therapy. 6689600, U.S; other patents pending.

1529

INTRONN

Fax: (512) 708-9311

Add: 710 W. Main St. Suite 150 Durham, NC 27701-2801

E-mail: [email protected]

Tel: (919) 686-2068

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1531

E-mail: [email protected]

475

INVENTUS BIOTEC GMBH & CO. KG

Web site: www.intronn.com President/CEO: Lloyd G. Mitchell, M.D. Research director: Dr. Mariano A. GarciaBlanco R&D expertise: R&D, products manufacture of gene delivery and gene therapy, gene repair, gene cloning, validation markers; forensic sample validation markers; and antibodies for research; other biotech medicines. Technological expertise: Q, AB, BI, C/TC, GA, GT, P/S, RD Principal products/instrumentation: Oligonucleotide analytical and purification reagents. Main products/instrumentation under R&D: SMaRT (spliceosome mediated RNA transsplicing) Gene Therapy, preclinical; forensic sample markers, development; validation markers, development; forensic sample validation markers, research antibodies. Sealed and granted patents: WO 98/14275 (Marker controls for sample validation). U.S. 6,013,487.

1530

IN/US SYSTEMS, INC.

Add: 5809 North 50 St. Tampa, FL 33610-4809 Tel: (813) 626-6848 Fax: (813) 620-3708 E-mail: [email protected] Web site: www.inus.com President/CEO: Dr. Edward Rapkin, Ph.D. Research director: Russell Schavey R&D expertise: Development and manufacture of radioisotope instruments for scientific research. Technological expertise: CH/S, DD, D-D, PG Principal products/instrumentation: B-RAM, Y-RAM, GC-RAM.

Add: Nottulner Landweg 90 Muenster 48161 Germany Tel: (49) 2534-800-126 Fax: (49) 2534-800-124 E-mail: [email protected] Web site: www.inventus-biotech.com President/CEO: Dr. Norbert Barteteko Research director: Dr. Ulrich Mueller R&D expertise: Development and manufacture of electrochemical biosensors for patient self-control as well as for clinical diagnostics, food technology and biotechnology research. Technological expertise: E, BA, PMC Principal products/instrumentation: Dietary supplement, Formula Vitae®, contract research/clinical trial products. Main products/instrumentation under R&D: Electrochemical biosensors for determining the level of lactate, ascerbic acid, uric acid and glucose; immunosensor.

1532

INVERESK RESEARCH

Add: Tranent East Lothian, Scotland EH33 2NE U.K. Tel: (44) 1875-614-545 Fax: (44) 1875-614-555 E-mail: [email protected] Web site: www.inveresk.com President/CEO: Dr. Walter Nimmo R&D expertise: Contract scientific research and development/manufacture for pharmaceutical, biopharmaceutical, specialty chemical, consumer products, and veterinary industry products. Technological expertise: AF, AB, BS, C/TC, GA, GT, G, H/CF, PB, CC, E, F, PA, Q, T, P G, PMC, P/S, RD, SMC

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Principal products/instrumentation: Antibodies, biologicals, pharmaceuticals, veterinary products, pesticides, specialty chemicals, process validation, contract research/clinical trial products, vaccines, in vitro toxicology testing method, cosmetics, detergents, natural products, reagents.

1533

INVESTIGACION APLICADA, S.A. DE C.V.

Add: 7 Norte #416 Tehuacan, Pue. 75700 Mexico Tel: (52) 2-383-0007 Fax: (52) 2-383-0214 E-mail: [email protected] President/CEO: Alejandro Romero M. Research director: Eduardo Lucio D. R&D expertise: Value added products R&D/manufacture of prevention, diagnostic and therapy drugs for animal health disorders. R&D collaboration: National University of Mexico (UNAM), Boheringer-Ingelheim Vetmedica. Key sales market contracts: Pet Ag, INC.; Biomune Co.

Fax: (760) 603-7229 Web site: www.invitrogen.com President/CEO: Lyle C. Turner Research director: Patrick Dillon, Ph.D. R&D expertise: Development and manufacture of products for gene cloning, expression and analysis; Production of electrophoresis systems, including precast PAGE gels, apparatus, stains and standards. Technological expertise: Q, RD, C/TC, G, BME, SI Principal products/instrumentation: TA cloning kits, Pichia Expression System; Baculovirus Expression System, reagents, contract research/clinical trial products, biologicals, diagnostics, human genome project; Mammalian Expression Vectors; hESC Media, a fully defined, serum- and feeder-free media formulated for the growth and expansion of human embryonic stem cells, 2007; Cell Culture Antifoaming Reagent, 2007; Magnetic Beads for IVD, 2007; Dynabeads® FlowComp™ Cell Isolation Technology, 2007; FlexiTube siRNA for analysis of small numbers of human or mouse genes, 2007; Human Protein Microarray, 2007; DynaChip™ HLA Antibody Analysis system technology, 2007.

Key license and trade contracts: Biomune Co.

Subsidiary bodies: Invitrogen BV, De Schelp R, 9351 NV Leek, The Netherlands.

Technological expertise: F, PA, P/S, C/TC, AB

Sealed and granted patents: TA Cloning.

Principal products/instrumentation: Mycotoxin Adsorbent, Zeolex, nutraceuticals, Immuno Dp, mycotrienin. Main products/instrumentation under R&D: Immunoglobulins (egg derived); antibodies, bursal derived; Gumboro vaccine, mycostatin, mycostatin FCT.

1535

IN VITRO SWEDEN AB

Add: Stockholm S-10031 Sweden Tel: (46) 8-306-010 Fax: (46) 8-306-015 E-mail: [email protected] Web site: www.invitro.se

1534

INVITROGEN CORP.

Add: 1600 Faraday Ave. Carlsbad, CA 92008 Tel: (800) 955-6288

President/CEO: Olof Jantze R&D expertise: Research of cell biology, molecular biology, microplate technology, related products development.

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Technological expertise: C/TC, CS, AB Main products/instrumentation under R&D: In vitro toxicology testing products, contract R&D products

477

R&D expertise: Research, development and manufacture of related tools for gene delivery. Joint ventures: Q.BIOgene (AdenoExpress). R&D collaboration: Cayla (France). Key license and trade contracts: Zeocin, Suicide Genes.

1536

IN VITRO TECHNOLOGIES, INC.

Add: 1450 S. Rolling Rd. Baltimore, MD 21227 Tel: (410) 455-1242 Fax: (410) 455-1245 E-mail: [email protected] Web site: www.invitrotech.com President/CEO: Paul M. Silber Research director: Albert P. Li R&D expertise: Contract in vitro testing laboratory, related products manufacture. Key sales market contracts: Charles River, Japan. All other sales direct. Technological expertise: E, C/TC, DD, HTDS Principal products/instrumentation: Contract manufacturing, products, in vitro toxicology testing, organ transplants/culture products, in vitro toxicology and drug metabolism testing services utilizing human and animal tissue, hepatocytes (fresh and cryopreserved) from human and many animal species, microsomes and S9, and plated, ready-to-use Caco-2 cells.

Technological expertise: T, AF, C/TC, CH/S, DD, GA, GT, G, P/S, RD, SY Principal products/instrumentation: Zeocin™ Selection Antibiotics, Mycoplasma Removal Agent, Microwaveable E.coli media™, Proprietary plasmid vectors. Main products/instrumentation under R&D: Confidential, suicide genes, tools for gene delivery. Sealed and granted patents: Suicide genes and many other pending.

1538

IOMAI CORPORATION

Add: 2421 Pennsylvania Ave. NW Ste 300 Washington, DC 20037-1718 Tel: (202) 955-7120 Fax: (202) 955-7125 E-mail: [email protected]. Web site: www.ioma.com President/CEO: Stanley Erck Research director: Gregory Glenn, M.D. R&D expertise: Development and manufacture of biopharmaceuticals and vaccine

1537

INVIVOGEN, INC.

Add: 3950 Sorrento Valley Blvd. Ste. A San Diego, CA 92121 Tel: (858) 457-5873

Joint ventures: Elan Corporation. R&D collaboration: Walter Reed Army Institute of Research, Nation Institute of Health, Purdue Pharmaceuticals.

Fax: (858) 457-5843

Key license and trade contracts: Elan Corporation.

E-mail: [email protected]

Technological expertise: PA, TE, DD, RD

Web site: www.invivogen.com

Principal products/instrumentation: N/A

President/CEO: Dr. Gerard Tiraby

Main products/instrumentation under R&D: Flu Vaccine, Preclinical; influenza vaccine,

Research director: Dr. Michele Tiraby

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Tetnus Vaccine, Phase I; inactivated Vaccine, multivalent Vaccine, H. Pylori Vaccine, preclinical; ETEC Vaccine, Phase I.

1539

IONTEK BIOTECHNOLOGY, LTD.

Add: Organize Sanayi Bol. Mavicad. 8. Sok. No: 4 Bursa 16159 Turkey

Main products/instrumentation under R&D: Computer hardware and software for drug research.

1541

IPT/MONSANTO CO.

Add: 800 N. Lindbergh Blvd. St. Louis, MO 63167 Tel: (314) 694-1000

Tel: (224) 243-6139

Web site: www.monsanto.com

Fax: (224) 243-2161

President/CEO: Richard J. Mahoney

E-mail: [email protected]

Research director: Philip Needleman, Ph.D.

President/CEO: Neajat Unal

R&D expertise: R&D/manufacture of cell/tissue culture, computer hardware/software and drug delivery.

Research director: Canbora Unal, Ph.D. R&D expertise: Biotechnology research, oligonucleotide and sequencing production. Technological expertise: BA, Q, C/TC, GA, P/S, RD, SMC, SY Principal products/instrumentation: Oligonucleotides, Salmonella LC-PCR. Main products/instrumentation under R&D: Hepatitis-C Virus detection, Phase I; Mycoplasma- PCR- based test, preclinical; Mycobactbria typing test, Phase I; oligonucleotide synthesizer, oligonucleotide affinity chromatography.

1540

IOTECH, INC.

Add: 25971 Cannon Rd. Cleveland, OH 44146

R&D collaboration: Washington University Medical School, Oxford University. Technological expertise: F, Q, E, T, RD, P/S, BA, C/TC, CH/S, SY, DD, D-D Main products/instrumentation under R&D: BioPharmaceuticals; crop plants for insect resistance, virus resistance, herbicide tolerance, quality traits, processing improvements; bovine somatotropin; porcine somatotropin. Subsidiary bodies: Life Sciences Research Center, 700 Chesterfield Pkwy. N„ St. Louis, MO 63198.

1542

IQ CORPORATION B.V.

Tel: (440) 439-4091

Add: Zernikepark 6E Groningen 9747 AN The Netherlands

Fax: (440) 439-4093

Tel: (31) 50-5757-010

Web site: www.iotech.com

Fax: (31) 50-5757-001

President/CEO: Walter N. Maclay

E-mail: [email protected]

R&D expertise: Development and manufacture of computer hardware and software for research and development of pharmaceuticals.

Web site: www.iqcorporation.nl

Technological expertise: CH/S

R&D expertise: Development, production and marketing of monoclonal antibody/reagent based diagnostic and research products.

Principal products/instrumentation: WorkBench PC™, WorkBench Mac™.

President/CEO: Dr. R. G. Lageveen Research director: Dr. R. van Weeghel

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Technological expertise: C/TC, H/CF

Fax: (949) 261-6522

Principal products/instrumentation: Reagents for flow cytometry, IQ Products, immunohistochemistry reagents and kits, CMV Brite Turbo kit, virus diagnostics, like the CMV Brite Turbo kit, Cytodetec kit, contract manufacturing products, diagnostics, reagents.

E-mail: [email protected]

Main products/instrumentation under R&D: Monoclonal antibody/reagent for research and diagnosis.

R&D expertise: R&D of tissue engineering, cell/tissue culture and gene therapy, related products manufacture.

1543

IRORI

Add: 9640 Towne Centre Drive San Diego, CA 92121 Tel: (858) 546-1300 Fax: (858) 546-3083 E-mail: [email protected] Web site: www.irori.com President/CEO: Richard Brown Research director: John Lillig Subsidiary of Discovery Partners International, R&D expertise: Development and manufacture of instrumentation and laboratory devices for combinatorial chemistry. Key license and trade contracts: Trega Biosciences, INC. Technological expertise: R, SMC, COC, BME Principal products/instrumentation: Laboratory instruments, biopharmaceuticals, combinatorial chemistry library. Main products/instrumentation under R&D: Laboratory devices for combinatorial chemistry.

Web site: www.irvinesci.com President/CEO: Michael Kelly, Ph.D. Subsidiary of Japan Energy Cooperation Research director: Jay Treat, Ph.D.

Technological expertise: F, TE, BA, H/CF, C/TC, GT Principal products/instrumentation: Serum free media (HB 101®, HB 104®, HB PRO™, IS BAG, IS CHO, IS293, Animal Protein Free CHO Media); fetal bovine serum; cell/tissue culture harvest, liquid and powdered cell culture media; sera products; Mycotrim® TC mycoplasma detection kit; Chang Medium®; OEM serum products for diagnostic calibrators and control manufacturers; bovine cholesterol concentrate; media products for human infertility specialists; diagnostic kits (Mycotrim® GU and RS, AminoStat ELM®). Main products/instrumentation under R&D: Chemically defined CHO media, tissue engineering products, gene therapy.

1545

ISC BIOEXPRESS

Add: 420 North Kays Dr Kaysville, UT 84037 Tel: (800) 999-2901 Fax: (800) 574-7892 E-mail: [email protected] Web site: www.bioexpress.com President/CEO: Gene Platter

1544

IRVINE SCIENTIFIC

Add: 2511 Daimler St. Santa Ana, CA 92705 Tel: (949) 261-7800

R&D expertise: Manufacture and marketing of biotechnology medicines and related equipment. Joint ventures: Plastics, protein purification products.

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Key sales market contracts: Bio 101, BTX, Greiner, Eppendorf, Gemini Biotech, Labnet, MBP, NagleNune, Owl, MSI, Pall Gelman, Techrte, Schleicher & Schuell, UVP, others. Technological expertise: Q, HTDS, G, C/TC, P/S Principal products/instrumentation: GENEMATE™ chemicals for electrophoresis, GENEMATE supplies and equipment. Main products/instrumentation under R&D: Protein purification products, biotech drug, labware, computer aided drug design.

1546

ISCD, INC.

Fax: (510) 559-8683 E-mail: [email protected] Web site: www.isiresearchsoft.com R&D expertise: R&D of various biotechnological software and bibliographic software. Technological expertise: CH/S, BTS Principal products/instrumentation: 3 bibliographic software packages, including End Note, Reference Manager and ProCite. EndNote Search Online, organize references and create bibliographies automatically. EndNote is a registered trademark of Niles & Associates, INC. Main products/instrumentation under R&D: Novel biotechnological softwares.

Add: 4700 Superior St P.O. Box 82531 Lincoln, NE 68504 Tel: (800) 228-4250 Fax: (800) 464-0318 E-mail: [email protected] Web site: www.isco.com President/CEO: Doug Grant R&D expertise: Development and manufacture of separation sciences and environmental products. Joint ventures: AFTCO. Technological expertise: P/S, CH/S, PMC, BME Principal products/instrumentation: SFE, HPLC, LPLC, Fraction Collectors, Syringe Pumps, Flash Chromatography, Water Quality Monitoring Instruments. Main products/instrumentation under R&D: Separation/purification technology, environmental pollution control devices.

1548

ISIS PHARMACEUTICALS

Add: 2292 Faraday Ave. Carlsbad, CA 92008 Tel: (760) 603-2490 President/CEO: Daniel L Kisner, M.D. Research director: David Ecker, Ph.D. R&D expertise: Discovery, design and development and manufacture of oligonucleotidebased therapeutics. R&D collaboration: Ciba-Geigy, Eisai, Kaketsuken, Perspective Biosystems, Millipore, Large Scale Biology. Key sales market contracts: Eisai Key license and trade contracts: PNA Group, VICAL, Queen’s University, CSHL, Baylor College of Medicine, University of North Carolina at Chapel Hill, McGill University, Emory School of Medicine. Technological expertise: C/TC, PMC, CH/S, SY, DD, D-D, AB, RD, Q, P/S, BA

1547

ISI RESEARCHSOFT

Add: 800 Jones St. Berkeley, CA 94710 Tel: (510) 559-8592

Principal products/instrumentation: vitravene (isis 2922), treat retinitis; Vitravene (ISIS 2922) to treat verinitis; vitravene fomiviren sodium injectable (antisense) for

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treatment of cytomegalovirus retinitis in patients with AIDS. Main products/instrumentation under R&D: ISIS 2105 to treat human papillomavirus, Phase II; ISIS 2922 fomvirsen to treat human cytomegalovirus retinitis, IND candidate; ISIS 2302 to treat psoriasis (topical), Phase III, ICAM-I, IND candidate; preclinical compounds for Ras, PKC-alpha, pl20, HIV; alicaforsen/2302, Phase II, 2007; ISIS 2503,3521, 5132, all antisense, anticancer, oligonucleotide-based therapeutics, preclinical or Phase III, 2008, ISIS 113715, Phase II,2008, ISIS 3011012, Phase II, 2008; renal transplant rejection, Phase III. Isis-SGLT zrx, an antisense agent that inhibits the production of sodium-dependent glucose co-transporter type2 (SGLT2), for the treatment of type II diabetes, Phase 1, 2009. Sealed and granted patents: Aminooxy functionalized oligomers, oligomer arrays and methods of using them. 6825331, U.S.; Labeled oligonucleotides, methods for making same, and compounds useful therefore. 6825338, U.S.; Synthesis of oligonucleotides on solid support. 6822088, U.S.; Oligonucleotides having A-DNA form and B-DNA form conformational geometry. 6737520, U.S.; Antisense modulation of PTPN12 expression. 6743909, U.S.; modified nucleoside triphosphates. 6900308, U.S.; Antisense modulation of CoREST expression. 6900306, U.S.; Backbone modified oligonucleotide analogues. 6900301, U.S.; Process for preparing peptide derivatized oligomeric compounds. 6762281, U.S.; Ligand-conjugated oligomeric compounds. 6762169, U.S.; Methods for removing dimethoxytrityl groups from oligonucleotides. 6794502, U.S.; Antisense modulation of superoxide dixmutase 1, soluble expression. 7132530; U.S.; Oligonucleolotides having sitespecific chiral phosphorothioate internucleoside linkages. RE39464, U.S.; Pyrimidine derivatives for labeled binding partners. 6951931, U.S.; Peptide-conjugated oligomeric

481

compounds. 6878805, U.S.; 2 modified oligonucleotides 6911540, U.S.; Antisense modulation of sphingosine-1-phosphate lyase expression 6692960, U.S.; Carbohydrate or 2modified oligonucleotides having alternating internucleodide linkages 7056896, U.S.; Nucleosidic and non-nucleosidic folate conjugates. 6861514, U.S.; Methods of modulating pharmacokinetics of oligonucleotides 6921812, U.S.; Syntheric methods and intermediates for triester oligonucleotides 6919437, U.S.; Antisense modulation of bcl—x expression. 7148204, U.S.; Modulation of hypoxia-inducible factor 1 alpha expression 7144999, U.S., other patents pending.

1549

ISM BIOPOLYMER, INC.

Add: 230 Murray St Sherbrooke, Quebec JIG 2K4 Canada Tel: (819) 821-7907 Fax: (819) 821-7905 E-mail: [email protected] President: Dr. Isabelle Boucher Research director: Dr. Isabelle Boucher R&D expertise: Development and manufacture of specialty enzymes and oligosaccharides for nutraceutical, pharmaceutical, cosmeceutical and agricultural markets. R&D collaboration: Sherbrooke.

University

of

Key sales market contracts: Sigma-Aldrich, Calbiochem-Novabiochem. Key license and trade contracts: University of Sherbrooke. Technological expertise: E, F, RD, BA, CB, PMC, P/S Principal products/instrumentation: Chirosan oligosaccharides, oligosan, chirosan polysaccharides, chitomer, chitosan oligosaccharides, specialty chemicals, chitosan polysaccharide.

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ISOGEN BIOSCIENCE BV

Principal products/instrumentation: Resolve IEF Gels, Glycohemogloben, Isoclean.

Add: PO Box 1779 Maarssen 3600 BT The Netherlands

Main products/instrumentation under R&D: Isoscan-Scanning densitometer — 510K, submitted; cytokine receptor, cytokine.

1550

Tel: (31) 346-555-083 Fax: (31) 346-554-430 E-mail: [email protected]

1552

President/CEO: Dr. Hans Beyersberger van Hene-gouwen Research director: Dr. Bert van Wijk. R&D expertise: Synthesis and analysis research of bimolecular, related products manufacture. Joint ventures: Ingeny BV, Leiden, The Netherlands, DNA mutation detection kits.

ISO TECHNOLOGIES, INC.

Add: 1125 Olivette Executive Parkway Suite 110 St. Louis, MO, U.S.A. 63132 Tel: (314) 995-6049 Fax: (314) 995-6025 Web site: www.istotech.com President/CEO: Joseph Feder, Ph.D.

Key license and trade contracts: Boehringer Mannheim — Digoxigenin labeling; Perseptive Biosystems, INC. — Peptide Nucleic Acid (PNA).

Research director: Joseph Feder, Ph.D.

Technological expertise: E, Q, COC, D-D, PB, P/S, SMC, SY

Technological expertise: TE, C/TC, D-D, RD, GA

Principal products/instrumentation: Synthetic DNA, including trademark EUROLIGO, Peptides, PNA, DNA Mutation Kits, DNA binding protein, DNA extractor.

Principal products/instrumentation: Biologicals, pharmaceuticals, cell/tissue culture products.

Main products/instrumentation under R&D: DNA mutation detection kits, peptide nucleic acid (PNA).

1551

R&D expertise: Applied research/development of biotechnology medicines, related products manufacture.

Main products/instrumentation under R&D: Biotech drug, biotechware, cytokine inducedkiller cells, cytokine therapeutics. Sealed and granted patents: Pending.

ISOLAB, INC. 1553

ISO TIS N.V.

Add: 3985 Eastern Rd Norton, OH 44203 Add: tissue engineers ISO TIS N.V. Prof. Bronkhorstlaan 10-D Bilthoven, Utecht 3723 MB The Netherlands

Tel: (216) 825-4525 Fax: (216) 825-8520 President/CEO: Andrew Jaffe

Tel: (31) 30-229-5229

Research director: Dr. Michael Jackson R&D expertise: R&D/manufacture biotechnology medicines.

of

Technological expertise: C/TC, GA, TE, D-D, RD

Fax: (31) 30-228-0255 E-mail: [email protected] Web site: www.isotis.com President/CEO: Prof. Dr. CA van Blitterswijk

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Research director: Prof. Dr. CA van Blitterswijk R&D expertise: Research and products development of tissue engineering (bone, cartilage, and skin); design of controlled drug delivery and biomaterials manufacture.

1555

ISRAEL OCEANOGRAPHIC & LIMNOLOGICAL RESEARCH, LTD.

Add: PO Box 8030 Haifa 31080 Israel

R&D collaboration: Synthes/Stratec, OctoPlus.

Tel: (972) 4-515-202

Key license and trade contracts: Osteotech, INC.

President/CEO: Dr. Yuval Cohen

Technological expertise: TE, C/TC, DD Principal products/instrumentation: Cement restrictor, Sliuttlestop®, Hydroxy apatite granules. Main products/instrumentation under R&D: Biomimetic Coating, CreatOs™, clinical; Tissue Engineered Bone, VivescOs™, preclinical; Tissue Engineered Cartilage, VivesCar™, preclinical; Tissue Engineered Skin, VivesCutan™, preclinical; Controlled Drug release matrix, PolyActive® SR, preclinical; Hydrodxy apatite bonefiller (coated). Sealed and granted patents: 5 new patents in the field of biomimetic coating and tissue engineered bone. IsoTis had a total of 85 patents, issued or pending.

483

Fax: (972) 4-511-911 R&D expertise: Culture of marine organisms for food and biochemicals. Development and manufacture of high-tech products and materials for the mariculture industry enterprises. Technological expertise: LC/TC, BA, ET Principal products/instrumentation: Marine medicinals, marine food, marine lipid concentrate, ω3-marine fatty acids.

1556

ISS, INC.

Add: Champaign, IL 61826-6930 Tel: (217) 359-8681 Fax: (217) 359-7879 E-mail: [email protected] Web site: www.iss.com

1554

ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH

Add: Reuven St. PO Box 19 Ness Ziona 70450 Israel Tel: (972) 8-381-656 Fax: (972) 8-401-404 R&D expertise: Development and manufacture of advanced products and processes in biotechnology medicines with a focus on novel products for the CNS. Technological expertise: C/TC, AB, BS, G Principal products/instrumentation: Novel drug for CNS, central nervous system depressants, central nervous system stimulants.

President/CEO: Ben Barbieri, Ph.D. Research director: Brett Feddersen, Ph.D. R&D expertise: Development, design and related products manufacture of steadystate/time-resolved fluorescence instruments, near infrared imaging, diode array detection for time-resolved fluorescence. Technological expertise: CH/S Principal products/instrumentation: K2™ multifrequency phase and modulations fluorometer, PCl™ photon counting spectrofluotometer, Koala sample compartment, High pressure cell system for spectroscopy. Main products/instrumentation under R&D: Near infrared oxygen sensors.

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Sealed and granted patents: FrequencyDomain Spectroscopy; #5,212,386; #5,323,010, #4,840,485.

1557

ISU PREFORMULATION & DRUG DELIVERY

Add: Idaho State University, Division of Pharmaceuticals 970 South 5 th Avenue, Pocatello, ID 83209-8334 Tel: (208) 282-4620 Fax: (208) 282-4482 E-mail: [email protected] Web site: www.rx.isu.edu/phamiaceutics Research director: Dr. Sudip K. Das Subsidiary of Idaho State University R&D expertise: Biopharmaceutical and bioprocess engineering research/manufacture. Technological expertise: AB, DD Principal products/instrumentation: Biologicals, biomaterials, in vitro toxicology testing technique, nutraceuticals, pesticides, pharmaceuticals, vaccines, peptides, drug delivery systems for products and antisense drugs. Main products/instrumentation under R&D: Bioprocess engineering technology, biopharmaceutical analysis system.

1558

ITEMA LOVLUNP SCANDINAVIA

Principal products/instrumentation: Reagents kits, GDS, enzyme immunoassay (ELA), enzyme-linked immunosorbent assay kit (ELISA kit). Main products/instrumentation under R&D: Enzyme activator, enzyme inhibitor, enzyme drug.

1559

IVD RESEARCH, INC.

Add: 5909 Sea Lion PL, Ste. D Carlsbad, CA 92008 Tel: (760) 929-7744 Fax: (760) 431-7759 E-mail: [email protected] Web site: www.ivdresearch.com President: David N. Lambillotte Research director: Jaime Peral R&D expertise: R&D of in vitro diagnostics for infectious diseases, related novel products manufacture. Technological expertise: PA, C/TC Principal products/instrumentation: Diagnostics, Antigen detection EIAs for giardia, cryptosporidium, E. coli 0157 (environmental); serum antibody EIAs for amebiasis, echinococcus, cysticercosis, toxoplasma, trichinella, toxocara, tetanus and diphtheria. Main products/instrumentation under R&D: EIA for Salmonella, shigella, campylobacter for food, enzyme inhibitor complex.

Add: Skoldinge 640 24 Sweden Tel: (46) 1-575-0680

1560

IVOVUS BIOLOGICALS, INC.

Fax: (46) 1-575-0681 E-mail: [email protected]

Add: PO Box 802 Littleton, CO 80160

President/CEO: Mats Dellgren

Tel: (303) 730-1950

R&D expertise: Research of enzymology and enzymatic technique, enzyme products development and manufacture. Technological expertise: E, ET, ERT

Fax: (303) 730-1966 E-mail: [email protected] Web site: www.novus-biologicals.com President/CEO: Karen M. Padgett

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R&D expertise: Development and production of reagents for biopharmaceuticals

485

Web site: www.ixsys.com

Technological expertise: PA, H/CF, PIS

President/CEO: Costa G. Sevastopoulos, Ph.D.

Principal products/instrumentation: Research reagents.

Research director: William D. Huse, M.D, Ph.D.

Main products/instrumentation under R&D: Reagents for biopharmaceuticals R&D.

R&D expertise: Applications research of synthesis based molecular design technology to develop and produce therapeutic products. R&D collaboration: Bristol-Myers Squibb.

1561

IXION BIOTECHNOLOGY, INC.

Add: 13704 Progress Blvd., Box 13 Alachua, FL 32615 Tel: (904) 418-1428 Fax: (904) 418-1983 E-mail: [email protected] President/CEO: David C. Peck Research director: Amnion B. Peck, Ph.D. R&D expertise: Drugs R&D of diagnosis and treatment of diabetes and oxalate-related disorders. R&D collaboration: University of Florida, Q-Med AB.

Key license and trade contracts: Biosite Diagnostics. Technological expertise: RD, COC, D-D Main products/instrumentation under R&D: Vitaxin for inhibition of angiogenesis, Phase I; anti-aloha.v.beta3 recombinant human antibodies. Sealed and granted patents: Methods for the synthesis of oligonucleotides by Codons Antialpha.v.beta3 recombinant human antibodies and nucleic acids encoding same. 6,531,580 U.S.; other patents pending.

1563

J & W SCIENTIFIC, INC.

Key license and trade contracts: University of Florida Research Foundation.

Add: 91 Blue Ravine Rd. Folsom, CA 95630

Technological expertise: RD, C/TC, GT

Tel: (916) 985-7888

Main products/instrumentation under R&D: DNA assay for oxalobacter formigenes, transplantable pancreatic islets, oxalate detection kit for urine or blood and oral enzyme replacement for oxalate control.

Fax: (916) 985-1101

Sealed and granted patents: Method for transdifferentiation of non pancreatic stem cells to the pancreatic differentiation pathway, 20080008689, U.S.

R&D expertise: Development and manufacture of columns for GC and CE.

1562

IXSYS, INC.

Add: 1901 Meadows Ave Fort Worth Texas U.S.A. 76226 Tel: (940) 725-1180

Web site: www.kellysearch.com President/CEO: Bob Clarke Research director: Roger Schirmer

Technological expertise: P/S Principal products/instrumentation: Evidex™, solid phase extraction cartridges for drugs of abuse testing; DB-1 and DB-5ms, gas chromatography columns for drugs of abuse testing; DB™ 17/1701, GC column for testing pesticides, mPAGE and mSil columns for CE; gas flowmeters for low flows, drug column chromatography, column reactors.

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JABSCO-A DIVISION OF ITT INDUSTRIES

Add: Bingley Road Hoddesdon, Herts EN11 OBU U.K. Tel: (44) 1992-450-145 Fax: (44) 1992-467-132 E-mail: [email protected] Web site: www.jabsco.com

Principal products/instrumentation: AffiniPure™, AffiniSorbed™, several antibodies, ChromPure™, imntunoglobulins, ImmuoGold™ labeled antibodies, Biotin-SP™ (long spacer) antibodies, fluorescent antibodies, enzyme labeled antibodies. Main products/instrumentation under R&D: Affinity-isolated antibodies, affinity-purified antibodies, purified immunoglobulins and conjugates.

President: Mike Gill Research director: David Cresswell

1566

JACOBS ENGINEERING

Subsidiary of ITT Industries. R&D expertise: Pump development and manufacture. Technological expertise: BME, CW Principal products/instrumentation: HY2 Line Hygienic pumps, ultimapumps, pureflo pumps. Main products/instrumentation under R&D: Pump spray, pump check valve.

1565

JACKSON IMMUNO RESEARCH LABS, INC.

Add: 872 W. Baltimore Pk P.O. Box 9 West Grove, PA 19390 Tel: (610) 869-4024

Add: Merrion House Merrion Road Dublin 4 Ireland Tel: (353) 1668-1426 Fax: (353) 1269-5497 R&D expertise: R&D and manufacture of engineering drugs, pharmaceuticals Technological expertise: T, F, C/TC, PMC, BA, GT, P/S, CH/S Principal products/instrumentation: Engineered antibodies, diagnostics, pharmaceuticals, process validation, engineering vaccines, contract manufacturing products, biologicals, engineered protein, engineering cell. Main products/instrumentation under R&D: Engineering bacteria, engineering cell, engineering ribozymes.

Fax: (610) 869-0171 E-mail: [email protected] Web site: www.biosupplynet.com/cfdocs/ suppliers/supp_det.cfm?supp_id=963 President/CEO: William J. Stegeman, Ph.D. Research director: Cynara Y. Kb, Ph.D. R&D expertise: Development and production of affinity-isolated antibodies, affinity-purified antibodies, purified immunoglobulins and conjugates. Technological expertise: PA, P/S

1567

JAEGER BIOTECH ENGINEERING, INC.

Add: P.O. Box 3004 Costa Mesa, CA 92628 Tel: (714) 662-0937 Fax: (714) 662-1347 E-mail: [email protected] Web site: www.biobank.co.kr/maker/jjj/jaeger. shtml President: Rolf Jaeger

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Research director: Brad Dawson, Ph.D.

Tel: (81) 3-5745-2001

R&D expertise: Development and manufacture of bioreactors, porous glass carriers for the immobilization of immortalized cells, and related novel equipment.

Fax: (81) 3-5745-2025

Key sales market contracts: Schott Glass, Mainz Germany. Technological expertise: BA, C/TC, PMC Principal products/instrumentation: SIRAN™ porous glass carriers, bioreactors for protein and antibody production, fermenters, related novel equipment, including customized engineering equipment. Main products/instrumentation under R&D: Porous glass carriers, immobilization of immortalized cells.

1568

487

Web site: www.jsw.co.jp/en/ President/CEO: Naohiko Yagi Research director: Tadamoto Sakai R&D expertise: Development and manufacture of fermentation, synthesis and equipment. Technological expertise: F, BA, CH/S, SY, BME Principal products/instrumentation: Large steel materials, fine chemical products, plastic processing machines, industrial machines, defense equipment. Main products/instrumentation under R&D: Biodegradable polyesters, biodegradable plastics, fermentograph.

JANDAR INDUSTRIES, INC. 1570

JAS CO., INC.

Add: 1118 West Harris Rd, Suite 102 Arlington, TX 76017

Add: 28600 Mary’s Court, Easton, MD 21601

Tel: (817) 229-8053

Tel: (410) 822-1220

Fax: (817) 557-1074

Fax: (410) 822-7526

President/CEO: John C. O’Shea

E-mail: [email protected]

R&D expertise: Development and manufacture of biomedical laboratory diagnostic devices, components and research products specialize in bulk production processing, separation, and purification of blood serums.

Web site: www.jascoinc.com

Technological expertise: P/S, C/TC, BME Principal products/instrumentation: Biomedical laboratory products, including tissue culture grade serums, diagnostic grade serums and serum components, laboratory diagnostic devices. Main products/instrumentation under R&D: Separation and purification of blood serum.

1569

JAPAN STEEL WORKS, LTD.

Add: Hibiya Mitsui Bldg. 1-2, Yuraku-cho, 1chome, Chiyoda-ku Tokyo 100 Japan

President/CEO: Wayne Kottkamp Research director: Wayne Kottkamp R&D expertise: Development and manufacture of analytical instrumentation. Technological expertise: CC, SMC, CB, D-D, HTDS, PB, P/S Principal products/instrumentation: UV/ VIS/NIR Spectrophotomers, FTIR Spectrometers, Circular Dichroism Spectrometers, Raman Spectrometers, Polarimeters High Pressure Liquid Chromotography, Mass Spectrometers. Main products/instrumentation under R&D: Analytical chromatograph. Subsidiary bodies: Japan, U.K., Germany, Italy, France, Spain and Benelux.

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JEIO TECH CO., LTD.

Add: 4F Hyorim B/D 380-1 Seogyo-dong Mapo-ku, Seoul 121-83 South Korea

Technological expertise: C/TC Main products/instrumentation under R&D: MIST Alert™ for PSP (international R&D trials), aquaculture.

Tel: (82) 2-333-3049 Fax: (82) 2-3143-1824 E-mail: [email protected] Web site: www.jeiotech.com

1573

JENCONS SCIENTIFIC, INC.

President/CEO: Kim Jin Euk

Add: 800 Bursca Dr., Suite 801 Bridgeville, PA 15017

Research director: Kim Tae Yun

Tel: (800) 846-9959

R&D expertise: Development and manufacture of biomedical lab equipment (shakers, incubators, ovens, water baths, bath circulators, constant temperature and humidity chambers, etc.).

Fax: (412) 257-8809

Technological expertise: E, F, COC, SY Principal products/instrumentation: Incubators, ovens, shakers, water baths, bath circulators. Main products/instrumentation under R&D: Remote-controlled stirring hotplate. Sealed and granted patents: Rubber supporting ring for fill traction (Nos. 41849, 41850); Remote-controlled stirring hotplate (No. 57921); other patents pending.

1572

JELLETT BIOTEK LIMITED

Add: 1400-1801 Hollis Street Halifax, Nova Scotia B3J 3N4 Canada

E-mail: [email protected] Web site: www.jenconsusa.com President /CEO: Michael Williams R&D expertise: Development and production of liquid handling instrumentation. Technological expertise: BME, SI Principal products/instrumentation: Liquid handling instruments, contract R&D products. Main products/instrumentation under R&D: Liquid chromatograph-mass spectrometer.

1574

JENCONS SCIENTIFIC, LTD.

Add: VWR International Hunter Boulevard Magna Park Lutterworth Leicestershire LE17 4XN –U.K. Tel: (44) 1455-558-600

Tel: (902) 424-8670

Fax: (44) 1455-558-586

Fax: (902) 424-4679

E-mail: [email protected]

E-mail: [email protected]

Web site: www.jencons.co.uk

Web site: www.innovacorp.ns.ca/jbiotek

President /CEO: Robert Williams

President/CEO: Dr. Joanne Jellett

R&D expertise: Research, design and manufacture of liquid handling products.

Research director: Elizabeth Belland R&D expertise: Development and manufacture of aquaculture. R&D collaboration: National Research Council of Canada, Halifax, NS; MIST Alert™ for PSP (paralytic shellfish poisoning).

Technological expertise: R, BME Principal products/instrumentation: Liquid handling products, biologicals, contract research/ clinical trial products, cosmetics, detergents, diagnostics, pharmaceuticals, instrumentation.

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Subsidiary bodies: Bridgeville, PA, 15017, U.S.A. Tel: (412) 257-8861 and Fax: (412) 257-8809; E-mail: [email protected].

1575

JENNER BIOTHERAPIES, INC.

1576

489

JENWAY, INC.

Add: 743 Alexander Rd. Ste. 5 Princeton, NJ 08540 Tel: (609) 987-9659 Fax: (609) 987-0403

Add: 541 Kenosha St. Walworth, WI 53184

E-mail: [email protected]

Tel: (32) 9233-1404

President/CEO: Jim Christie

Fax: (32) 9233-0016

Research director: Martyn Fall

E-mail: [email protected]

Subsidiary of Protean, PLC

Web site: www.jennerbio.com

R&D expertise: Development and manufacture of biomedical laboratory instruments and equipment

President/CEO: Anthony E. Maida, II, MA, MBA R&D expertise: R&D/manufacture of recombinant vaccines for the therapy of cancer immunomodulators (macrophage activators) for adjuvant therapy of osteogenic sarcoma and abrogation of mucositis, GI toxicity and myelosuppression; other biopharmaceutical development and manufacture. R&D collaboration: Walter Reed Army Institute of Research. Key license and trade contracts: Eli Lilly & Co. — worldwide licensing agreement; Novartis, Ltd. — exclusive worldwide licensing agreement. Technological expertise: F, PI Main products/instrumentation under R&D: ACT™ (LMTP-PE) for osteogenic sarcoma, completed accrual of 710 patients in (ACT) — Phase III randomized prospective trial; ACT™ (LMTP-PE) for adjuvant therapy, Phase III; Oncovax-Pr™, for prostate cancer, Phase I/II clinicals complete; Oncovax-CL™, for colorectal cancer, in Phase I/II clinicals; JBT3002 (CGP 40774) for mucositis, Phase I clinicals. Subsidiary bodies: Use & composition of matter patents — OncoVax Pr, OncoVax-CL, OncoVax-C, JBT3002, MtP-PE, AdjuVaxl00a — U.S. and foreign counterparts (over 130 patents applications and foreign filings).

Technological expertise: BME, SI Principal products/instrumentation: Model 6300 Visible Spectrophotometer, Model 3345 Ion Analyzer, Model 4330 pH/Conductivity Meter, Model 6200 Fluorimeter, Waterproof pH, D02, Conductivity, Ion Portable Meters, Ceramic Hotplate/Stirrers, UV/V1S Spectrophotometers, Turbidimeter. Main products/instrumentation under R&D: Scanning UV/VIS Spectrophotometer with Kinetics, Final phase.

1577

JENWAY/INC

Add: 743 Alexander Rd., Ste. 5 Princeton, NJ 08540-6328 Tel: (44) 1785-812-121 Fax: (44) 1785-810-405 E-mail: [email protected] Web site: www.jenway.com President/CEO: Martyn Fall Research director: Sheridan Haggerty R&D expertise: R&D of electrochemistry and spectrophotometry, related novel products manufacture. Technological expertise: AMS

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Principal products/instrumentation: Spectrophotometers, Flame photometer, Electrochemistry meters (pH, conductivity, dissolved oxygen), Fluorimeter. Subsidiary bodies: Jenway Ltd., Gransmore Green, Felsted, Dunmow, Essex CM6 3LB, U.K.

1578

JERINI BIO TOOLS GMBH

Add: Rudower Chaussee 29 Berlin 12489 Germany

Sealed and granted patents: Anti-cancer (VEGF-Antagonist); Anti-Viral (HIV); Duotope Scan Technology, and Spot Synthesis, other patents pending.

1579

JEROME H. HOLLAND LABORATORY

Add: 15601 Crabbs Branch Way Rockville, MD 20855 Tel: (302) 303-5000 Fax: (301) 738-0553

Tel: (49) 30-9789-3088

Web site: www.redcross.org

Fax: (49) 30-9789-3105

President/CEO: Leon W. Hoyer, M.D.

E-mail: [email protected]

Research director: Donna Sobieski

Web site: www.jerini.com

Subsidiary of American Red Cross, Biomedical Services

President/CEO: Dr. Schneider-Mergener Research director: Dr. Uirich Reineke R&D expertise: Development of peptides, peptide instrumentation and proprietary technology platform; production of test kits (peptide arrays), development of therapeutic compounds, compound libraries on continuous surfaces. R&D collaboration: Bayer, Boehringer Ingelheim U.S., Monsanto, Noxxon, Procter & Gamble, Schering Plough and others. Technological expertise: PS, SSMSA, HTDS, SMC, P/S, COC, CH/C, CB, BI, R, SY, PB Principal products/instrumentation: Pep Spots™, Phospho Spots™, Combi Spots™, Proteides & Protease Spots™, Peptide arrays for binding assays, cellulose bound Pepspots, Peptide™ libraries for solution assays, cleavable PepSpots™, Kinase Substrates, PhosphoSpots™, and Protease assay, Protease Spot™. Subsidiary bodies: U.S. Office: 201N. Front St, Ste. 410, Wilmington, NC 28401, Tel: (800) 916-0075, Fax: (910) 762-2249, E-mail: [email protected], U.S. Office contact: Greg Wessel.

R&D expertise: Biomedical drug products R&D in support of American Red Cross Biomedical Services. Technological expertise: GT, AB, P/S, GA, H/CF, C/TC, CH/S, SQ, E, T, RD, PMC Main products/instrumentation under R&D: Contract development products, vegetable drugs, biologics.

1580

JIANGSU KANION PHARMACEUTICAL CO., LTD.

Add: No. 58, Heichang Nanlu, Xinpu District, Lianyungang City 222000, Jiangsu, P. R. China Tel: (86) 518-8552-1748 Fax: (86) 518-8541-0217 E-mail: [email protected] Web site: www.kanion.com R&D expertise: R&D and manufacture of innovative TCM. Technological expertise: HNT, TCMM Principal products/instrumentation: Guizhi Fuling capsule: soft capsules granulator of

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international advanced standard with a production line of an annual output of 1.2 billion capsules, small dosage injection production line with an annual output capacity of 30 million dealing with 10,000 tons Chinese herbal medicines per year to extract workshop. Main products/instrumentation under R&D: Guizhi Fuling capsule U.S. Phase II clinical trials.

1581

JINGMEI BIOTECH CO., LTD.

Add: P.O. Box 024, Kaiyuan Bldg. No. 7001 Beihuan Da Dao, Shenzhen 518034, P. R. China Tel: (86) 755-8354-6191 Fax: (86) 755-8354-6196

491

Web site: www.jmscience.com President/CEO: John D. MacFarlane R&D expertise: R&D/manufacture of columns and detectors for HPLC; Bioprocess control technology. Technological expertise: P/S, BA, PMC, CPHC Principal products/instrumentation: Columns, detectors and accessories for all scales of HPLC, HPLC-grade reagents, HPLC-grade solvent. Main products/instrumentation under R&D: Liver cell clone, extracorporeal liver-assist devices. Sealed and granted patents: Liver cell clones for use in extracorporeal liver-assist device, 6,294,380, U.S.

E-mail: [email protected] Web site: www.jingmei.com

1583

JM SCIENCE, INC.

President/CEO: Min Luo Research director: Mingze Liu R&D expertise: Research and development of diagnostics, immunology, molecular biology, and instruments, related novel products manufacture.

Add: P.O. Box 250 355 Lang Blvd. Grand Island, NY 14072 Tel: (716) 774-8706 Fax: (716) 774-8708

Key sales market contracts: BD/Pharmingen.

E-mail: [email protected]

Technological expertise: E, F, PA, Q, T, AB, C/TC, GA, GT, G, H/CF, P/S, RD

Web site: www.jmscience.com

Principal products/instrumentation: Torch Elisa, Jingmei Biotech, Cytokine Elisa, Genzyme.

R&D expertise: R&D/manufacture of biomedical equipment and instrumentation.

Main products/instrumentation under R&D: Hormone ELISA, preclinical; Tumor Marker Elisa, preclinical; One step tests, preclinical.

Principal products/instrumentation: CIM disks and columns.

1582

JM SCIENCE CANADA, INC.

Add: 1474-B Wallace Rd. Oakville, Ontario L6L 2Y2 Canada Tel: (905) 825-3438 Fax: (905) 847-1695 E-mail: [email protected]

President/CEO: John D. MacFarlane

Technological expertise: CC, P/S, PMC

Sealed and granted patents: Liver cell clones for use in extracorporeal liver-assist device. 6,294,380, U.S.

1584

JOHN BROWN/AKER KVAERNER PHARMACEUTICALS

Add: 440 Route 22 East P.O. Box 720421 Bridgewater, NJ 08807-6884

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Tel: (908) 429-9100 Fax: (908) 429-3942 E-mail: [email protected] President/CEO: Tom Gallatin Research director: Peter R. Wilkes Subsidiary of Trafalgar House Plc R&D expertise: Engineering/construction of biomedical facilities for the regulated industries; Service company-engineering.

cartridges, detergent removal cartridges, chromatographic media, columns and ion pH monitor; FlashMaster, an automated flash chromatography system. Main products/instrumentation under R&D: Polypeptide, peptide synthesizer, peptide scanning technique, peptide sequencer.

1586

Technological expertise: P/S, BA, RD, E, PMC, C/TC, LP Principal products/instrumentation: Biologicals, biopharmaceuticals, diagnostics, specialty chemicals, vaccines, enzymes. Subsidiary bodies: Houston, TX; Greenville, SC.

JORDAN ENGINEERING U.K., LTD.

Add: Millbrook Rd. Stover Trading Estate Bristol, Avon BS17 5JW U.K. Tel: (44) 1454-328-300 Fax: (44) 1454-328-385 President/CEO: J. R. Foley Subsidiary of Jordec Group plc

1585

JONES CHROMATOGRAPHY

Add: New Road Hengoed, Midglamorgan CF82 8AU U.K. Tel: (44) 1443-818-111 Fax: (44) 1443-816-552 E-mail: [email protected] Web site: www.laboratorynetwork.com/ storefronts/jones.html President: W. C. Jones

R&D expertise: R&D and manufacture of high quality stainless steel ware products; installation of mechanical plant and process pipework, including Ultra Clean facilities. Technological expertise: BME Key license and trade contracts: Licensed distributor of Ariel range of reciprocating compressors. Principal products/instrumentation: Contract development products, high quality stainless steel ware products.

Research director: R. C. Towill R&D expertise: Research of peptides and peptide instrumentation, related products development and manufacture. Technological expertise: CS, P, PI, PIS, PS, P/PS, PPAT, PS/AP Joint ventures: Jones Chrom. Inc, Jones Chrom. Malaysia. Key sales market contracts: Michrom Bioresources, Biosepra, Eldex. Principal products/instrumentation: Ultrafast microprotein analyzer, fraction collectors, peristaltic pumps, detectors, peptide trap

1587

JORDON SCIENTIFIC — A DIVISION OF JORDON/ FLEETWOOD/FOGEL, LLC.

Add: 2200 Kennedy St. Philadelphia, PA 19137 Tel: (215) 535-8300 Fax: (215) 289-1597 E-mail: [email protected] Web site: www.jordonscientific.com President/CEO: Gene Sterner

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R&D expertise: R&D and manufacture of refrigeration for the pharmaceutical enterprises and scientific industry. Technological expertise: BME Principal products/instrumentation: Refrigerator, contract R&D products. Main products/instrumentation under R&D: Refrigerated centrifuge, refrigerated microcentrifuge, refrigeration system.

493

Web site: www.jrhbio.com President/CEO: Tom Giarla Research director: Karen Etchberger, Ph.D. Subsidiary of CSL Limited R&D expertise: Manufacture and marketing of products for cell culture and bioprocessing applications. Key sales market contracts: IntroGene, Gropep (distribution agreement). Technological expertise: C/TC

1588

JOUAN, INC.

Add: 170 Marcel Dr. Winchester, VA 22602 Tel: (540) 869-8623 Fax: (540) 869-8626 E-mail: [email protected] Web site: www.jouaninc.com President/CEO: Lyle E. Cady, Jr. Research director: Donald Gillette R&D expertise: Development of cell and tissue culture, laboratory biomedical equipment manufacture. Technological expertise: C/TC, P/S, H/CF, BME Principal products/instrumentation: Biosafety cabinets, freezers — ultra low temp, centrifuges. Laboratory biomedical equipment, including centrifuges, CO2 incubators, vacuum concentrator systems, and media preparators, ultra low temperature freezers, biosafety cabinets. Main products/instrumentation under R&D: Cell and tissue culture, labware, laboratory reagents.

Principal products/instrumentation: Cell culture and tissue culture products: serum requiring media; serum-free media, proteinfree media; serum; media supplements; growth factors and reagents, fetal bovine serum — donor calf serum, bulk liquid media transfer, dry power media, custom media, growth factors, cell culture media and serum. Subsidiary bodies: Denver, PA; Buckinghamshire, U.K.; Victoria, Australia: Andover, U.K.

1590

JULABO USA, INC.

Add: 754 Roble Rd., Suite 180 Allentown, PA 18103 Tel: (610) 231-0250 Fax: (610) 231-0260 E-mail: [email protected] Web site: www.julabo.de President/CEO: Ralph Juchheim Subsidiary of Julabo Labortechnik GmbH

1589

JRH BIOSCIENCES

Add: 13804 W. 107th st. Lenexa, KS 66215 Tel: (913) 469-5580 Fax: (913) 469-5584 E-mail: [email protected]

R&D expertise: Development and manufacture of instrumentation for pharmaceutical production. Technological expertise: BA, COC Principal products/instrumentation: Constant temperature equipment, chillers and waterbaths.

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JULE BIOTECHNOLOGIES, INC.

Add: Suite 695 25 Science Park New Haven, CT 06511 Tel: (203) 786-5490

Sealed and granted patents: Production of FSH.

1593

JUSTICE LABORATORY SOFTWARE

Fax: (203) 786-5489 E-mail: [email protected] President/CEO: George T. Leka Research director: Diane Kichar R&D expertise: R&D/manufacture of precast gels and reagents for the electrophoresis market.

Add: East Coast North America 1 Indian Road, Suite 2 Denville, NJ 07834 Tel: (973) 586-8551 Fax: (973) 627-0947 E-mail: [email protected]

Technological expertise: P/S

Web site: www.justiceeurope.com

Principal products/instrumentation: SnapA-Gel™ Precast gels, Jule Gradient Formers™, Large precast gels, Running Buffers and Sample Buffers.

President/CEO: Jeff Justice

Sealed and granted patents: Gradient former patents (Dual piston design), plastic cassette patents.

1592

JUROX PTY, LTD.

Add: 85 Gardiners Rd. Rutherford, NSW 2320 Australia Tel: (61) 2-4931-8200 Fax: (61) 2-4932-7880

Research director: Rolland Luo R&D expertise: Development and manufacture of scientific software for the pharmaceutical analytical laboratory. Technological expertise: CH/S Principal products/instrumentation: ChromPerfect for Windows Chromatography Data System, ChromPerfect Enterprise NT-based Client Server System, ChromPerfect for HPGCs. Main products/instrumentation under R&D: Scientific software for the pharmaceutical analytical laboratory.

Web site: www.jurox.com.au President/CEO: John O’Brien Research director: Dr. Peter Kieran R&D expertise: R&D/manufacture of veterinary pharmaceutical and animal products. Key license and trade contracts: I.C.P. (New Zealand), licensed to make and sell folliclestimulating hormones (FSH) under the patents.

1594

KAKEN PHARMACEUTICAL CO., LTD.

Add: 28-8, Honkomagome 2-chome, Bunkyolku Tokyo 113-8650 Japan Tel: (81) 3-5977-5046 Fax: (81) 3-5977-5135

Technological expertise: F, BA, P/S, DD, D-D

E-mail: [email protected]

Principal products/instrumentation: Antibodies, anaesthetics, antibiotics, veterinary drugs.

Web site: www.kaken.co.jp

Main products/instrumentation under R&D: Antibiotics, steroid chemistry reagents, FSH.

Research director: Tomohiko Munakata, Ph.D.

President /CEO: Yoshiharu Wakiyama

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R&D collaboration: Toray, Tokyo Tanabe, Seikagaku Kogyo, Lederle Japan, Green Cross, Scios Nova, Tulane University, Wyeth Ayerst, Procyte Corp. Key sales market contracts: Seikagaku Kogyo, Boots, Helsinn Healthcare SA. R&D expertise: R&D of cell/tissue culture, gene amplification and process monitoring control, related novel products manufacture. Technological expertise: C/TC, PMC, CH/S, S, D-D, DD, SY, AT, BP, RD, P/S, GA, HF Principal products/instrumentation: Artz (injectable hyaluronic acid for osteoarthritis), Adofeed (NSAID plaster), Keiperazon (cephem antibiotic), Empynase (anti-inflammatory), Sonifilan (immuno-potentiator), Broncholin (bronchodilator), Ebrantil (anti-hypertensive), Proheparum (liver hydrolysate), Bentos (antiglaucoma), Procylin (peripherovascular disease), Mentax (antifungal), Ropion (injectable NSAID), Kasugamycin (rice fungicide), Polyoxin (general fungicide), Salinomycin (coccidiostat for broilers), Lysocellin (feed additive, growth promotor). Main products/instrumentation under R&D: Basic Fibroblast Growth Factor (bFGF) for refractory skin ulcers, Phase III; Growth Hormone Releasing Peptide (GHRP) for dwarfism, preclinical; Copper-peptides for alopecia, preclinical. Subsidiary bodies: New York, Dusseldorf. Sealed and granted patents: Novel strains belonging to the genus paenibacillus and method of controlling plant disease by using these strains or culture thereof, 2007248583, U.S.

Fax: (44) 1509-631-739 President /CEO: Mike Broomby Research director: Derek Palmer R&D expertise: R&D/manufacture of instrumentation using flow injection analysis for in vitro diagnostic, environmental and combinatorial chemistry applications. Technological expertise: COC, HTDS, BME Main products/instrumentation under R&D: Point of core device, final testing; high throughput device, developing tank, flow injection analyzer for in vitro diagnosis. Sealed and granted patents: Key patents on using flow injection analysis for various applications.

1596

KALIBRANT LIMITED

Add: 2 Oakwood Dr. Loughborough LE11 3NH U.K. Tel: (44) 1509-452-046

KAMADA, LTD.

Add: Kibbutz Beit Kama M.P. Negev 85325 Israel Tel: (972) 8-940-6472 Fax: (972) 8-940-6473 President /CEO: David Tsur Research director: Dr. Shabtai Bauer R&D expertise: Development and production of high quality biopharmaceutical products, specializing in sterile injectable solutions. Technological expertise: TE, SY, HTDS Principal products/instrumentation: Serum albumin, immunoglobulins. Main products/instrumentation under R&D: High quality biopharmaceutical products.

1597 1595

495

KAMIYA BIOMEDICAL CO.

Add: 12779 Gateway Drive, Seattle, WA 98168 Tel: (206) 575-8068 Fax: (206) 575-8094

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E-mail: [email protected] Web site: www.kamiyabiomedical.com President/CEO: Kohji Kamiya Research director: Douglas K. Palmer, Ph.D. R&D expertise: Development and manufacture of immunoassay reagents, enzyme inhibitors, monoclonal and polyclonal antibodies, research assay kits. Technological expertise: PA, AB, MAE, E, ET, DK

Main products/instrumentation under R&D: DNA — Probes test kit for leishmania, Phase III, SBIR; DNA detection kits using microtiter KamPlates; HIV viral load test kits for research use; Solid-phase PCR technology and microassays.

1599

KAMTERTER II, LLC.

Add: 1025 North 33rd St. Lincoln, NE 68503

Principal products/instrumentation: Serum Protein Immunoassays, Apoptosis Research Products, Multi-Drug Resistance Research Products, Protein Kinase Inhibitors/Staurosporine, Calphosrin C.

Tel: (402) 466-1224

Main products/instrumentation under R&D: Immunoassay reagents, enzyme inhibitors, monoclonal/polyclonal antibodies, research assay kits.

President /CEO: John A. Eastin

1598

KAMTEK, INC.

Add: 7858 Beechcraft Ave. Gaithersburg, MD20879

Fax: (402) 466-1351 E-mail: [email protected] Web site: www.kamterter.com Research director: Chris Petersen R&D expertise: Seeds and biologicals development, manufacture/marketing. Joint ventures: Monsanto, Oil-Dri; Corp. of America, Sakata Seed Corporation, U.S. Tobacco.

Tel: (301) 208-2505

R&D collaboration: Monsanto, Oil-Dri; Corp. of America, Sakata Seed Corporation, U.S. Tobacco.

Fax: (301) 208-2507

Technological expertise: F, T, AF, BA, G

E-mail: [email protected]

Principal products/instrumentation: Seed enhancement/priming, seed microbial inoculation.

Web site: www.kamtekinc.com President/CEO: Dr. Sharanjit S. Vedbrat Research director: Dr. Sharanjit S. Vedbrat R&D expertise: Contract research for government and private sector clients; applied research of virology, immunology, molecular biology, diagnostics and cell biology; specifically develop test kits based on DNA coated microliter KamPlates™. Technological expertise: H/CF, C/TC, GA, DK Principal products/instrumentation: DNA coated KamPlates™ (microliter plates); contract research/clinical trial products.

Main products/instrumentation under R&D: Solid matrix seed priming, seed culture, seed plant breeding true. Subsidiary bodies: Stockton, CA. Sealed and granted patents: Solid matrix seed priming, chemical treatment and microbial treatment family of patents.

1600

KARO BIO AB

Add: Halsovagen 7 Novum Huddinge S-141 57 Sweden

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Tel: (46) 8-608-6000 Fax: (46) 8-774-8261 E-mail: [email protected] Web site: www.karobio.se President/CEO: Per-Olof Martensson Research director: Dr. Per Otteskog R&D expertise: R&D and manufacture of hormone-receptor specific and tissue-selective pharmaceuticals; drug discovery research. R&D collaboration: Merck & Co. and BristolMyers Squibb. Technological expertise: F, Q, SMC, RD, P/S, GA, R, C/TC, CH/S, SY, D-D, HTDS, DDI Main products/instrumentation under R&D: Drug discovery and development programs in the area of hormone replacement therapy, breast cancer, cardiovascular diseases, hypercholesterofemia, and inflammatory diseases, type 2 diabetes; hormone receptor.

497

Key license and trade contracts: Axys Advanced Technologies (chemical libraries and medicinal chemistry); Trega Biosciences (chemical libraries). Technological expertise: SMC, G, HTDS, PIS Principal products/instrumentation: BioKey™ assay, Molecular Braille™. Main products/instrumentation under R&D: Antimicrobial agents, preclinical; synthetic peptide libraries, peptide library design programs, assays and screening instruments. Sealed and granted patents: Synthetic peptide libraries, peptide library designs, biopolymer ligands for HTS; other patents pending.

1602

KATZEN INTERNATIONAL, INC.

Add: Suite K 2300 Wall Street Cincinnati, OH 45212 Tel: (513) 351-7500 Fax: (513) 351-0810

1601

KARO BIO USA, INC.

Add: 4222 Emperor Blvd. Ste. 560 Durham, NC 27703 Tel: (919) 474-8888 Fax: (919) 474-0103 E-mail: [email protected] Web site: www.spoke.com/info/cCnfM/Karo BioUsaInc

E-mail: [email protected] Web site: www.katzen.com President /CEO: Philip W. Madson Research director: Dale A. Monceaux R&D expertise: Development and design/ manufacture of engineering technique for pilot process and commercial processes. Technological expertise: F, P/S, BA, PMC

Subsidiary of Karo Bio AB

Principal products/instrumentation: Fermentation ethanol processes, ethanol precipitation methods, cellulase enzyme technology, yeast production processes, cellulase enzyme fermentation.

R&D expertise: Drug discovery technologies development, related novel products manufacture.

Main products/instrumentation under R&D: Ethanol from cellulose.

President/CEO: D. Joe Smith Research director: Dana M. Fowlkes, M.D., Ph.D.

Joint ventures: PPD Discovery ( joint discovery). R&D collaboration: Bayer AG; Ares Serano; Novartis Crop Protection; GPC Biotech AG; NovImmune SA (all assays and screening for genomics targets).

1603

KAYE INSTRUMENTS, INC.

Add: 1100 Technology Park Drive Billerica, MA 01821

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Tel: (978) 437-1000

1605

KELAB

Fax: (978) 437-1021 Web site: www.kayeinc.com

Add: Knipplagatan 10 Goteborg S414 74 Sweden

Subsidiary of Bowthorpe.

Tel: (46) 31-125-160

President/CEO: Ken Hurley

Fax: (46) 31-148-260

R&D expertise: Development/manufacture of validation system for process monitoring, validation and enforced reporting.

E-mail: [email protected]

Technological expertise: CH/S, PMC

R&D expertise: R&D/manufacture of antibodies, amino acids, biochemicals, peptides.

E-Mail: [email protected]

Principal products/instrumentation: Windowsbased Validation System, Validator® KL; Labwatch™ Stability Monitoring System; Validator® Software. Main products/instrumentation under R&D: Validation system for process monitoring.

1604

KEBO LAB AB

Add: 163 94 Spanga Sweden

Web site: www.kelab-biochem.com President /CEO: Karl-Erik Ljung

Technological expertise: PA, RD, COC, G, HTDS, PG, PB Principal products/instrumentation: Specialty biochemicals, antibodies, peptides, biopharmaceuticals. Main products/instrumentation under R&D: Monoclonal/polyclonal antibodies, amino acids and derivatives, peptide T, peptide nucleic acids.

Tel: (46) 8-621-3400 Fax: (46) 8-760-4596

1606

KEM-EN-TEC A/S

E-mail: [email protected] Web site: www.kebolab.com President/CEO: Kent Karlsson Subsidiary of Merck KgaA. R&D expertise: Manufacturing and allotting of laboratory products in Sweden, Norway, Denmark and Finland. Specializing in cell and molecular biology research products. Technological expertise: F, PA, AB, Q, TE, T, BA, CB, C/TC, COC, GA, G, HTDS, H/CF, P/S, RD, R, SMC, SY Principal products/instrumentation: Biomedical laboratory equipment, biopharmaceuricals, reagents, pharmaceuticals. Main products/instrumentation under R&D: Various new instruments/equipment for cell and molecular biology research.

Add: Lerso Parkalle 42 Copenhagen 2100-DK Denmark Tel: (45) 3927-1777 Fax: (45) 3920-0178 E-mail: [email protected] Web site: www.kem-en-tec.dk President /CEO: Henrik Christensen Research director: Margit Wikborg R&D expertise: R&D/manufacture of peptides, peptide instrumentation, and other biotechnology medicines; specializing in diagnostic components. Joint ventures: Immonodex histochemistry reagents; Amdex together with Dako on diagnostics; upfront chromatography together with DDCA.

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R&D collaboration: MD Foods, Novo Nordisk, AMPC.

Tel: (301) 620-7100

Key sales market contracts: Novex, CBS, Repligen, Bio 101, CLE, Elchrom, Roche Diagnostics, Robbins, Fermentas, Mobiikontes, Turner.

E-mail: [email protected]

Key license and trade contracts: Roche Diagnostics. Technological expertise: E, CS Principal products/instrumentation: Custommade peptides, Liquid Substrates (TMB, DNPP); Substrate Tablets, Enzymes, Avidin, Streptabidin. Main products/instrumentation under R&D: Peptide sequencer, peptide synthesizer, histochemistry reagents, pre-stained TMB (tetramethylbenzidine) substrates. Sealed and granted patents: Pre-stained TMB substrates.

499

Fax: (301) 620-7492 President/CEO: Christopher W. Kemp, Ph.D. R&D expertise: Cell culture research; development and manufacture of cell culture products and cell culture media. Technological expertise: F, P/S, BA, C/TC Principal products/instrumentation: Cell culture media, glutamine assay kits, protein assay kits; contract manufacturing products.

1609

KENDLE INTERNATIONAL

Add: 441 Vine Street Suite 500 Cincinnati, OH 45202 Tel: (800) 733-1572 Fax: (513) 381-5870

1607

KEMIN BIOTECHNOLOGY LC.

Add: 2100 Maury St. Des Moines, IA 50322 Tel: (515) 559-5100

E-mail: [email protected] Web site: www.kendle.com President/CEO: Mike Minor

President/CEO: Christopher Nelson

R&D expertise: Various drug, clinical trial design and management, investigations, recruiting, NDA preparation, DSR management, statistical analysis, NDA submissions, contract sales.

Research director: Friedhelm Brinkhaus

Technological expertise: D-D, AF, CH/S

Joint ventures: Interlink Biotechnologies L.C.

Principal products/instrumentation: Contract drug research/clinical trial products.

Fax: (515) 559-5232 Web site: www.kemin.com

R&D expertise: Development and manufacture of enzymes and other biotechnology medicines. Technological expertise: E, F, Q, T, AF, BA, CB, GA, P/S, RD Main products/instrumentation under R&D: Agriculture, biologicals, natural products, enzymes, enzyme drug, antimicrobial proteins, transgenome.

1610

KENDRICK LABORATORIES, INC.

Add: 1202 Ann St. Madison, WI 53713 Tel: (608) 258-1565 Fax: (608) 258-1569

1608

KEMP BIOTECHNOLOGIES, INC.

Add: 7307 Governors Way Frederick, MD 21704

E-mail: [email protected] Web site: www.kendricklabs.com President/CEO: Nancy Kendrick, Ph.D. Research director: Jon Johansen

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R&D expertise: Protein electrophoresis and software development, specializing in protein 2-dimensional electrophoresis software. Technological expertise: Q, P/S Principal products/instrumentation: Phoretix software for 1-D and 2-D PAGE gel analysis using Windows 05-compatible computers. Main products/instrumentation under R&D: Protein 2-dimensional electrophoresis softwares.

Fax: (49) 618-490-7474 E-mail: [email protected] Web site: www.kendro.com President/CEO: Dr. Hermann Brendecke Research director: Dr. Ludwig Bergann R&D expertise: Research, development, sales and marketing of laboratory biomedical equipment Technological expertise: P/S, BA, C/TC, HTDS, H/CF

1611

KENDRO LABORATORY PRODUCTS

Principal products/instrumentation: Incubators, centrifuges, ovens, microbiological safetycabinets, other biomedical equipment.

Add: 31 Pecks Lane Newtown, CT 06470-2337 Tel: (203) 270-2203 Fax: (203) 270-2210 E-mail: [email protected]

1613

KENT LABORATORIES, INC.

Web site: www.kendro.com

Add: 777 Jorgensen PL Bellingham, WA 98226

President/CEO: Mark Adams

Tel: (360) 398-8641

R&D expertise: Designing, developing, manufacturing, and marketing of sample preparation products and life science instruments

Fax: (603) 954-6333

Technological expertise: TE, BA, C/TC, COC, D-D, GT, G, HTDS, P/S, R, BA Principal products/instrumentation: Centrifuges, ovens, incubators, biological safety cabinets, freezers and equipment, sample preparation products. Main products/instrumentation under R&D: Sample preparation devices, sample preparation thin-layer chromatography. Subsidiary bodies: Hanau and Osterode, Germany.

1612

KENDRO LABORATORY PRODUCTS

Add: Heraeusstr. 12-14 Postfach 1563 Hanau 63450 Germany Tel: (49) 618-490-6940

E-mail: [email protected] Web site: www.kentlabs.com President/CEO: Donald A. Jorgensen Research director: Donald A. Jorgensen R&D expertise: Development and manufacture of antisera human proteins, R.I.D. plates and kits, labeled antisera. Technological expertise: PA, BS, PPAT, P/PS Principal products/instrumentation: Antisera, R.I.D. plates, custom antisera production, Rh antiserum. Main products/instrumentation under R&D: Antisera human proteins.

1614

KENT SCIENTIFIC CORPORATION

Add: Kent Scientific Corporation 1116 Litchfield Street Torrington, CT 06790

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Tel: (860) 626-1172

1616

501

KETT

Fax: (860) 626-1179 E-mail: [email protected] Web site: www.kentscientific.com

Add: 17853 Santiago Blvd. Ste. 107-504 Anaheim, CA 92861

President/CEO: Andrew H. Ide

Tel: (714) 974-8837

Research director: Andrew H. Ide

Fax: (714) 974-8877

R&D expertise: Development/manufacture/ supply of biomedical research equipment.

E-mail: [email protected]

Technological expertise: CH/S, DD, R, BME

President/CEO: John Bogart

Principal products/instrumentation: Biomedical research equipment, specializing in complete, pharmacology and physiology products, including cardiovascular, non-invasive blood pressure and respiratory monitoring, isolated organ and tissue systems. Workbench and data acquisition systems. Special items include blood vessel and microtissue perfusion, force and pressure transducers.

R&D expertise: R&D/manufacture of laboratory biomedical and industrial equipment

Web site: www.kett.com

Technological expertise: PMC, BME Principal products/instrumentation: NIR Moisture Meters, KJT 100, 200, 300; Micro Moisture Balance, FM300; IR Moisture Balance, ED620, FD100, FD240; Laboratory Mixing Systems, BL600, BL300.BL1200.

1617 1615

KERNCO INSTRUMENTS CO., INC.

KEYGENE N.V.

Add: Agro Business Park 90 P.O. Box 216 Wageningen 6700 AE The Netherlands

Add: 420 Kenazo Ave, El Paso, TX 79928

Tel: (31) 317-466-866

Tel: (915) 852-3375

Fax: (31) 317-424-939

Fax: (915) 852-9084

E-mail: [email protected]

E-mail: [email protected]

Web site: www.keygene.com

Web site: www.kerncoinstr.com

President/CEO: Mark Vaeck

President/CEO: John P. Kelly

Research director: Pieter Vos

Research director: John P. Kelly

R&D expertise: Development, design, manufacture and application of molecular techniques to improve the process of plant and animal breeding.

R&D expertise: Manufacture/sale and allotment of laboratory instruments such as pH, conductivity, temperature, contact angle meters, etc. Technological expertise: PMC, BME Principal products/instrumentation: pH meters, viscosity testers, clinical refractometers, conductivity testers, temperature and humidity testers, contact angle meters, microscopes, lab refractometers. Main products/instrumentation under R&D: Conductivity detector, conductometer, pH monitor, temperature cycler, temperature sensor.

R&D collaboration: Current shareholders (leading Dutch plant breeding companies) and third parties. Key license and trade contracts: Manufacturing and sales of AFLP™-kits (Life Technologies and Perkin Elmer/Applied Biosystems); AFLP technique to several companies. Technological expertise: AB, BI, C/TC, CH/S, GA, R, Q, T, RD

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Principal products/instrumentation: Contract research/clinical trial products, AFLP kits for plant genome fingerprinting, Life Technologies (radioactive detection), Perkin Elmer/Applied Biosystems (fluorescent detection), AFLP Software for plant and microbial fingerprinting, AFLP analysis services. Main products/instrumentation under R&D: Kit for animal fingerprinting, general method for DNA fingerprinting. Subsidiary bodies: AFLP data service. Sealed and granted patents: Selective restriction fragment amplification: a general method for DNA fingerprinting (EP 0534 858 Al).

1618

KEYS, RONALD B./RONALD B. KEYS, JD, PHD

Add: 43-06 159 St., Ste. B2 Flushing, NY 11358 Tel: (954) 448-1515 Fax: (718) 460-3466 E-mail: [email protected] Web site: www.brainlink.com/~rkeysphd/ President/CEO: Ronald B. Keys, Ph.D. R&D expertise: Development and manufacture of longevity biomedicine protocols.

E-mail: [email protected] Web site: www.keystonelabs.com President/CEO: Cy Cabradilla, Jr. Research director: Dragan Spasic R&D expertise: R&D/manufacture of custom DNA synthesis, nucleic acid based diagnostics, modified oligonucleotides, antisence synthesis. Technological expertise: Q, AB, RD, GA Principal products/instrumentation: Custom development products. Main products/instrumentation under R&D: DNA repair synthesis, nucleic acid based diagnostics, modified oligonucleotides, antisense RNA synthesis.

1620

KIBOW BIOTECH, INC.

Add: 3624 Market St., University City Sci. Center, Ste. 522 Philadelphia, PA 19104-2614 Tel: (610) 353-5130 Fax: (610) 353-5110 E-mail: [email protected] Web site: www.kibowbiotech.com President/CEO: Dr. Jack Dickstein Research director: Dr. N. Ranganathan

Technological expertise: SMC, AF, BI, GA, GT, PG

R&D expertise: R&D of biotech medicines and biomedical equipment

Principal products/instrumentation: Acidbase home biochemistry kit.

Technological expertise: CB, COC, DD, D-D, PG, SY, SMC

Main products/instrumentation under R&D: Longevity biomedicine protocols.

Main products/instrumentation under R&D: Monitoring and hand-held meter-test for kidney function, preclinical; oral medical therapeutic product to be used as a substitute of adjunct therapy for dialysis, preclinical.

1619

KEYSTONE LABORATORIES, INC.

Add: 600 E 17th St S Suite B Newton, IA 50208

1621

KIMIA CORPORATION

Tel: (800) 858-5227

Add: 2102-B Walsh Ave. Santa Clara, CA 95050

Fax: (641) 792-7989

Tel: (408) 748-1046

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Fax: (408) 748-0846 E-mail: [email protected] Web site: www.kimiacorp.com President/CEO: Fariba Aria, Ph.D. Research director: Fariba Aria, Ph. D

503

Main products/instrumentation under R&D: Antidiabetic compounds, Phase I completed; protein drugs, protein carrier, protease inhibitor, ILK inhibitor. Sealed and granted patents: Antidiabetic compounds, novel protein-kinases, ILK inhibitors.

R&D expertise: Custom synthesis research of specialty organic compounds. Technological expertise: CC, COC, PB, P/S, SMC, SY

1623

KINETIC IMAGING, LTD.

Principal products/instrumentation: A wide range of small organic molecules, intermediates, contract manufacturing products, natural products, reagents, unusual amino acids, building blocks for combinatorial chemistry, linkers for solid phase synthesis.

Add: South Harrington Building Sefton St. Liverpool L3 4BQ U.K.

Main products/instrumentation under R&D: Specialty organic compounds.

Web site: www.sciencecentral.com

Tel: (44) 151-709-8661 Fax: (44) 151-709-8633 E-mail: [email protected] President/CEO: Mark Browne, Ph.D. R&D expertise: Development and manufacture of scientific imaging, mainly biomedicine.

1622

KINETEK PHARMACEUTICALS, INC.

Add: 1779 West 75th Ave. Vancouver, BC V6P 6P2 Canada

Technological expertise: C/TC, CH/S, GT Principal products/instrumentation: Komet, Kalcium PC, Tempus PC, Cyclops, Fenestra, Stereology, Lucida, KIC 101 Archive.

Tel: (604) 267-7654 Fax: (604) 267-7667 E-mail: [email protected] Web site: www. Kinetekpharm.com

1624

KINETICS BIO/PHARM DIVISION

President/CEO: Andre Archimbaud

Add: Seven Penn Center, 1635 Market St. Philadelphia, PA 19103

Research director: Dr. Jasbinder Sanghera

Tel: (215) 656-2500

R&D expertise: Discovery research/development and manufacture of drug (in focus: proteinkinases) therapeutic products to treat diabetes, cancer and other diseases of aging.

Fax: (215) 561-4444

R&D collaboration: National Research Council of Canada, University of British Columbia, University of Toronto.

President/CEO: Frank Knou

Key license and trade contracts: University of British Columbia, University of Toronto, University Health Network Technological expertise: C/TC, BI

E-mail: [email protected] Web site: www.kineticsbiopharm.com Subsidiary of US Filter/Vivendi. Joint ventures: US Filter, immediate parent company which was acquired by Vivendi, the European Water Company; all architecture and engineering and construction management companies.

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R&D expertise: Design and manufacture of equipment/instrumentation for pharmaceutical industry enterprises. Technological expertise: F, R, BA, C/TC, CH/S, DD, P/S Principal products/instrumentation: Tote bins — bulk handling/containers, Thomas Conveyor — conveyor parts/systems, WHE Biosystems — modular skids, FTS — freeze dryers and lyophilizers. Main products/instrumentation under R&D: Intelligence design software of water systems for end-user. Sealed and granted patents: Water tool — intelligent design software for water systems for end-user, many patents pending.

1625

KINETICS GROUP, INC.

Add: 4226 Surles Ct., Suite 500, Durham, NC 27703 Tel: (919) 474-4600 Fax: (919) 474-8214 Web site: www.kinetics.net President/CEO: David Shimmon R&D expertise: Design, manufacture and installation of validated process utility systems.

Tel: (604) 323-2547 Fax: (604) 323-2548 E-mail: [email protected] Web site: www.kinexus.ca President/CEO: Dr. Steven Pelech Research director: Dr. Steven Pelech R&D expertise: Protein kinase profiling R&D service — bioinformatics related to protein kinases and signal transduction research, related novel products manufacture. Technological expertise: G, P/S, E, PA, Q, BT, C/TC, CH/S Principal products/instrumentation: Biosensors, diagnostics, human genome project, biopharmaceuticals, contract R&D products. Main products/instrumentation under R&D: Protein kinase profiling, protein kinase signal transducers.

1627

KIRKEGAARD & PERRY LABORATORIES, INC.

Add: 2 Cessna Ct. Gaithersburg, MD 20879 Tel: (301) 948-7755 Fax: (301) 948-0169 Web site: www.kpl.com

Technological expertise: BA

President/CEO: Albert Perry

Principal products/instrumentation: Bioreactor Skids, Ultra-Filtration Skids and Ultrapure Water — Analytical Test Carts.

Research director: William Hearl, Ph.D.

Main products/instrumentation under R&D: Validated process utility systems, validated targets.

1626

KINEXUS BIOINFORMATICS CORPORATION

Add: 8755 Ash Street, Suite 1 Vancouver, British Columbia, V6P 6T3 Canada

R&D expertise: Development and manufacture of affinity purified antibodies and substrates for microwell ELISA and Western blotting. Technological expertise: P/S, C/TC, PMC, CH/S Principal products/instrumentation: Affinity purified antibodies, contract manufacturing products, conjugates, substrates for microwell ELISA, immunoblotting and immunohistochemistry, nucleic acid labeling and detection systems, ELISAmate® kits for microwell ELISA and Western blotting; Histomark®

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immunohistochemicals, Bactrace® antibacteria antibodies, ProFLOK® poultry diagnostic kits.

1628

KLOEHN COMPANY, LTD.

Add: 10000 Banburry Cross Dr., Las Vegas, NV 89134 Tel: (702) 243-7727 Fax: (702) 243-6036

505

Principal products/instrumentation: Tri-cat® (adrenaline, noradrenaline, dopamine), acetylcholine receptor antibodies, RRA melatonin, RIA-catecholomines, steroids, autoimmune ELISA’s. Main products/instrumentation under R&D: Human recombinant antigens for autoimmune and infectious disease assays. TPO, RO, LA, -Ul-sn rNP dsDNA, CENP-b, b2-glvcoprotein, TGgRO-60, Ro52.

E-mail: [email protected] Web site: www.kloehn.com President/CEO: Mike Kloehn

1630

KMI/PAREXEL, LLC.

R&D expertise: Manufacturing and marketing of fluidic components for OEM instrumentation.

Add: 195 West St. Waltham, MA 02451

Technological expertise: BME

Fax: (781) 487-0525

Principal products/instrumentation: Fluidic components for OEM instrumentation, MICRO syringes, INERT shear valves, syringe pumps, syringe filter, solenoid valves.

Tel: (781) 434-4800 E-mail: [email protected] Web site: www.kminc.com President/CEO: Ronald Tetzlaff Subsidiary of Parexel International, Inc.

1629

KMI DIAGNOSTICS, INC.

Add: 818 51st Av., N.E., Suite 101 Minneapolis, MN 55421-1746 Tel: (612) 572-9354 Fax: (612) 586-0748 E-mail: [email protected] Web site: www.kmidiagnostics.com President/CEO: Mark A. Kowal Research director: Mark A Kowal R&D expertise: Research and development of diagnostic assays for antigens, infectious disease, autoimmune and endocrinology related fields diseases. Technological expertise: C/TC BS Key license and trade contracts: Distributors for IBL — Hamburg, Germany; Diarect — Freiburg, Germany; Orgentec Diagnostika — Mainz, Germany; Viro-Immuno-Oberusel, Germany.

R&D expertise: Compliance and validation of R&D services for pharmaceutical, biotechnology and medical device industries. Technological expertise: BTS, CH/S Key sales market contracts: Kaye Instruments; General Electric Instrument Control Services. Principal products/instrumentation: GMPware™ Intelligent Software Tools. Main products/instrumentation under R&D: Validated targets. Subsidiary bodies: 3625 Brookside Parkway Ste 550, Alpharetta, GA 30022-4434; Bannockburn Lake Office Park Plaza 2333 Waukegan Rd, Bannockburn, IL 60015; 1000 Park Forty Plaza Ste 500, Durham, NC 27713; Rose Tree Corporate Center 1400 N. Providence Rd Ste 2000, Media, PA 19063-2043; Via Filippo Turati, 28, Milano, Italy 20212; 12300 Twinbrook Parkway Ste 500, Rockville, MD 20852; 177 Bovet Rd Ste 545, San Mateo, CA 94402; 195 West St Waltham, MA 02451.

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KNAUER WISSENSCHAFTLICHE GERATEBAU GMBH

1633

KOCH MEMBRANE SYSTEMS, INC.

Add: Hegauer weg 38 Berlin D-14163 Germany

Add: 850 Main St Wilmington, MA 018873388

Tel: (49) 3080-9727

Tel: (978) 694-7000

Fax: (49) 30801-5010

Fax: (978) 657-5208

E-mail: [email protected]

E-mail: [email protected]

Web site: www.knauer.net

Web site: www.kochmembrane.com

President/CEO: Dr. Ing. Herbert Knauer

President/CEO: David Perry

Research director: Dr. Heitz

Research director: Mahesh Mehta, Ph.D.

R&D expertise: R&D/manufacture of scientific instruments.

R&D expertise: Development and manufacture of ultrafiltration, microfiltration, and membrane filtration equipment.

Technological expertise: P/S, BME Principal products/instrumentation: High pressure liquid chromatography HPLC, simulated moving bed SMB, osmometer. Main products/instrumentation under R&D: Instruments for drug analysis, instruments available for drugs.

1632

KNOLL BIOPRODUCTS CO., INC.

Add: P.O. Box 2736 Santa Fe, NM 87504 Tel: (505) 983-4066 Fax: (505) 989-8660 E-mail: [email protected] Web site: www.knollbioproducts.anthill.com President/CEO: H. Andre Knoll, Ph.D. R&D expertise: Development, manufacture and marketing of biological products. Technological expertise: C/TC, GA, CS, BS Principal products/instrumentation: Bt insecticide, BIOCLEAN grease digestant for greasetraps, BIOSCENT odor digestant, SEPTOBAC septic tank treatment, BIODEX-50 hydrocarbon digestant for bioremediation, wastewater treatment products.

Technological expertise: F, BA, P/S, LP Principal products/instrumentation: RomiPro™ Hollow Fiber Cartridges, SpiraPro™ spiral modules, Tubular Cross-Flow Filtration, Lab and production systems, membranemembrane separation systems. Main products/instrumentation under R&D: Ultrafiltration fermentor, ultrafiltration membrane, microfiitration apparatus, membrane filter, membrane filter bioreactor.

1634

KODAK SCIENTIFIC IMAGING SYSTEMS

Add: 4 Science Park New Haven, CT 06511 Tel: (203) 786-5600 Fax: (203) 624-3143 E-mail: [email protected] Web site: www.kodak.com/go/scientific Research director: John Hooper, Ph.D. R&D expertise: Manufacture and marketing of imaging systems for scientific laboratory research. Technological expertise: CH/S Principal products/instrumentation: Kodak autoradiography films and accessories; Kodak

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imaging systems; In Vivo Multispectral Imaging System, 2007.

1635

507

Principal products/instrumentation: HPLC instrumentation, spectrofluorometers, spectrophotometers, ultracentrifuges, high speed refrigerated centrifuges, rotors, tubes.

KOMA BIOTECH, INC. 1637

KORAM BIOTECH CORP.

Add: 301, Gayang Technotown, 1487 Gayang 3 dong, Gangseo-gu Seoul, 157-793 South Korea

Add: Koram B/D, #664-31 Yorksam-dong Kaognam-ku, Seoul 135-081 South Korea

Tel: (82) 2-3662-7790

Tel: (82) 2-556-0311

Fax: (82) 2-3662-7730

Fax: (82) 2-556-0828

E-mail: [email protected]

E-mail: [email protected]

Web site: www.komabiotech.com,

Web site: www.korambiotech.com

President/CEO: Sang-FIoon Moon

President/CEO: Matt Hyun

R&D expertise: Development of biomedical laboratory instrumentation, related novel products manufacture.

R&D expertise: Development and manufacture of biotech research reagents

Technological expertise: PA, P/S, C/TC, H/CF, BME Principal products/instrumentation: Biologicals, instrumentation, plastics, reagents Main products/instrumentation under R&D: Laboratory scale purification devices, labwares, biotechwares, computer-aided drug design, biomedical laboratory new instruments.

1636

KONTRON INSTRUMENTS

Technological expertise: E, F, PA, Q, C/TC, GA, GT, PB, PG, P/S, RD, SY Principal products/instrumentation: Biotech research reagents. Main products/instrumentation under R&D: Analytical reagents.

1638

KORE TECHNOLOGY, LTD.

Add: Cambridge Science Park Milton Rd. Cambridge, Cambs CB4 0WF U.K. Tel: (44) 1353-653-030

Add: Factory: Via G. Fantoli, 16/15 Milan 20138 Italy

Fax: (44) 1353-653-031

Tel: (39) 2-580-8517

Web site: www.kore.co.uk

Fax: (39) 2-506-0918

President/CEO: Steve Mullock, Ph.D.

President/CEO: Vincenzo Morelli

Research director: Steve Mullock, Ph.D.

Research director: Edwin Bayiiss

R&D expertise: Research and manufacture of analytical sensors for biotechnology processing.

R&D expertise: Development and products manufacture of HPLC, Spectroscopy and centrifiguation Technological expertise: RD, P. S, PMC, BME

E-mail: [email protected]

Technological expertise: F, BA, PMC, CH/S Principal products/instrumentation: T-CAT time-of-flight mass spectrometer.

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Main products/instrumentation under R&D: Analytical sensors for fermentation control and monitoring.

1639

KOSAN BIOSCIENCES, INC.

President/CEO: Albert Perry Research director: Bill Hearl, Ph.D. R&D expertise: R&D/manufacture of reagents and kits for detection of proteins and nucleic acids, USDA-licensed pou ltry diagnostic kits.

Add: 3832 Bay Center Place Hayward, CA 94545

Key license and trade contracts: RAGE, Rapid Analysis of Gene Expression technology.

Tel: (510) 732-8400

Technological expertise: PA, P/S, GA, G

Fax: (510) 732-8401

Principal products/instrumentation: Reagents, substrates for ELISA, blotting and immunohistochemistry, affinity purified antibodies, nucleic acid labeling and detection kits; RedPhos™ Microwell Phosphatase Substrate System, a new colorimtric phosphatase substrate, 2008.

E-mail: [email protected] Web site: http://www.kosan.com/pipeline.html President/CEO: Daniel Santi Research director: Brian Metcalf R&D expertise: Development, manufacture and manipulation of polypeptide synthase genes. R&D collaboration: Johnson & Johnson. Technological expertise: F, RD, AF, D-D Main products/instrumentation under R&D: Erythromycin analogs, fk 506 analogs, epothilone, raparnycin analogs, polypeptide synthase genes, polypeptide synthase enzymes. Sealed and granted patents: 5672491; Modified modular PKS with retarned scaffold. 6391594, U.S.; Transposon-based transformation system. 7138279, U.S.; Isolated nucleic acids relating to the fkbA gene within the fk520 polypeptide synthase gene cluster. 6503737, U.S. Nucleic acids encoking narbonolide polymerize synthase enzymes from streptomyces narbonensis. 6303767, U.S.

Main products/instrumentation under R&D: Reagents and kits for detection of proteins and nucleic acids, BluePhos® phosphatase substrate. Sealed and granted patents: BluePhos phosphatase substrate.

1641

KPS SCIENTIFIC PRODUCTS CO.

Add: A-160, G.F., Dayanand Colony Lajpat Nagar, New Delhi 110024 India Tel: (91) 11-621-5363 Fax: (91) 11-622-6894 E-mail: [email protected] Web site: www.deb.VsnLnet.in President/CEO: Dr. S. Sethi

1640

KPL

Add: 2 Cessna Court, 910 Clopper Road, Gaithersburg, MD 20879 Tel: (301) 948-7755 Fax: (301) 948-0169 E-mail: [email protected] Web site: www.kpl.com

R&D expertise: Development and manufacture of biotechnology medicines products. Joint ventures: Endogen, Inc., Biological Industries, VWR Scientific. Technological expertise: E, F, PA, BI, C/TC, H/CF Principal products/instrumentation: Tissue culture, R&D equipments.

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Main products/instrumentation under R&D: Biotech medicine, vaccine therapy.

1642

KRAEBER GMBH & CO.

509

R&D collaboration: DNA Plant Technology — coffee improvements. Main products/instrumentation under R&D: Fermentation and rDNA techniques for food ingredients, DNA plant technology, fermentograph.

Add: Waldhofstrasse 14 Ellerbek D-25474 Germany Tel: (49) 410-130-5308

1644

Fax: (49) 410-130-5390 E-mail: [email protected]

KRAMEL BIOTECH INTERNATIONAL, LTD.

Web site: www.kraeber.de

Add: South Nelson Rd. Cramlington, Northumberland NE23 9WF U.K.

President/CEO: Jens-Uwe Kraeber

Tel: (44) 1670-732-992

Research director: Roland Petroschka

Fax: (44) 1670-730-454

R&D expertise: Development and products manufacture of cell and tissue culture, animal blood fractions, biologicals, biochemicals in bulk.

E-mail: [email protected]

Technological expertise: PB, C/TC, P/S, SY, BA, CB

R&D expertise: R&D/manufacture of molecular biology consumables: vaccines, enzymes, DNAs and kits.

Principal products/instrumentation: Animal blood fractions from the local animals in Europe, biologicals, sera, plasma and other biochemicals, contract filtration products. Main products/instrumentation under R&D: Cell and tissue culture, animal blood fraction.

1643

KRAFT FOODS, INC.

Add: Technical Center Kraft Ct Glenview, IL 69925 Tel: (800) 230-2967

President/CEO: Lou McNulty Research director: Philip Eastlake

Key sales market contracts: Distributors in the U.K. for BTX Genetronics, Edge Biosystems, Quantum Biotechnologies, Mobitec. Technological expertise: E, F, Q, P/S, RD Principal products/instrumentation: Contract manufacturing products, single strand DNA preparation kit, Quickstrand; Restriction endonudeases; DNA modifying enzymes; DNA vectors and markers. Main products/instrumentation under R&D: Molecular biology research reagents, vaccinotherapy.

Fax: (877) 208-0782 Web site: www.kraftfoodscompany.com

1645

KREATECH DIAGNOSTICS

President/CEO: Robert Morrison Subsidiary of Philip Morris Cos. R&D expertise: Fermentation/microorganism development, related novel products manufacture. Technological expertise: FE, F, DK

Add: Keienbergweg 3 Amsterdam 1101 EZ The Netherlands Tel: (31) 35-642-1216 Fax: (31) 35-656-4806 E-mail: [email protected]

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Web site: www.annovum.nl

E-mail: [email protected]

President/CEO: H. J. Houthoff

Web site: www.kross-inc.com

Research director: R. Heetebry

President: Dr. Thomas Kenyhercz

R&D expertise: Development and manufacture of diagnostic products and licensing products.

R&D expertise: Development of regulatory affairs and quality systems, process and computer validations, neural network designs. related novel products manufacture.

Technological expertise: C/TC, GA, RD, SY Principal products/instrumentation: ULYSIS labeling kits, REMBRANDT DNA and RNA in situ hybridization and detection kits. Main products/instrumentation under R&D: mFISH, Rapid TB tests, universal linkage system. Sealed and granted patents: Universal linkage system (ULS), ABC.

1646

Technological expertise: BL, BS, CB, COC, DD, D-D, TE, F, P/S, SMC Principal products/instrumentation: Biologicals, pharmaceuticals, diagnostics, biomaterials, vaccines, instrumentation, cosmetics, biosensors. Main products/instrumentation under R&D: Regulatory affairs and quality systems, computer validation.

KRONUS, INC. 1648

Add: Boise Research Center 12554 West Bridger St., Ste. 108 Boise, ID 83713

KUHLMAN TECHNOLOGIES, INC.

Tel: (208) 377-4800

Add: 10512 NE 68th St. Kirkland, WA 98033

Fax: (208) 377-4900

Tel: (425) 822-8282

E-mail: [email protected]

Fax: (425) 827-9055

Web site: www.kronus.com

E-mail: [email protected]

President/CEO: Christopher T. Viele

President/CEO: Michael W. Davis

R&D expertise: R&D and manufacture/ marketing of in vitro diagnostic test kits.

R&D expertise: R&D/manufacture of laboratory biomedical equipment and labwares.

Technological expertise: E, PA

Technological expertise: BME, SI.

Principal products/instrumentation: Diagnostic kits, reagents.

Principal products/instrumentation: Laboratory scale purification devices, labwares, Kuhlman water stills, pure steam generators and steam sterilizers; Kuhlman-Isotech sterility testing and aseptic filling isolators; lytzen dry heat sterilizers and SBM air-steam and hot water spray sterilizers, WFI and process tanks, stopper washers/sterilizer

Main products/instrumentation under R&D: In vitro diagnostic test kits, in vitro diagnostic agents, diagnostic enzyme, diagnostic reagents.

1647

KROSS, INC.

Add: 146 Flanders Dr. Suite 2000 Hillsborough, NJ 08876 Tel: (908) 369-1900 Fax: (908) 369-1331

1649

KVAERNER E & C

Add: 440 Rte. 22 East Bridgewater, NJ 088070884

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Tel: (908) 725-0111

Technological expertise: BME, P/PS, PC

Fax: (908) 722-0894

Principal products/instrumentation: Protein analysis system; amino acid analysis system; glyphosate analysis system; sugar analysis system.

E-mail: [email protected] Web site: www.kvaerner.com, President/CEO: J. Petchonka Subsidiary of Kvaerner ASA. R&D expertise: Engineering development in pharma and other biotech products. Technological expertise: BA Principal products/instrumentation: Agriculture, biologicals, specialty chemicals, instruments, natural products, nutraceuticals, pesticides, pharmaceuticals, plastics, process validation, toxic waste processing products.

1652

LABCONCO CORP.

Add: 8811 Prospect Ave Kansas City, MO 64132-2696 Tel: (816) 333-8811 Fax: (816) 363-0130 E-mail: [email protected] Web site: www.labconco.com President/CEO: John N. McConnell

1650

L&L MINING AND MILLING CO.

Add: 13593 N. Winchester Way Parker, CO 80138-8545 Tel: (720) 851-8120 Fax: (720) 851-8120 President/CEO: James J. Luedtke R&D expertise: R&D/manufacture of instrumentation for the detection of E. coli in the food industry. Technological expertise: AF, BA, COC, CH/S, P/S, F, Q, SMC, PMC Main products/instrumentation under R&D: Instruments to detect E. coli and food contamination in the food industry.

Research director: Kerm Dyer R&D expertise: Development and manufacture of laboratory biomedical equipment/ instrumentation. Technological expertise: P/S, BME, P/P Principal products/instrumentation: FreeZone® Freeze dry systems; CentriVap® centrifugal concentrators and cold traps; Protector® laboratory fume hoods; Purifier® safety cabinets; WaterPro® water purification systems.

1653

LAB CONNECTIONS

Add: 10 Bearfoot Road Ste. 200 Northborough, MA 01532-1528 1651

LABALLIANCE

Add: 349 N. Science Park Rd. State College, PA 16803

Tel: (508) 480-9777 Fax: (508) 481-9764 E-mail: [email protected]

Tel: (800) 523-1546

Web site: www.labinternet.com

Web site: www.laballiance.org

President/CEO: David Botten

President/CEO: Kert Ivie

Research director: James Dwyer

R&D expertise: Development of protein and amino acid analysis systems, related novel products manufacture.

R&D expertise: Development and manufacture of laboratory instrumentation for interfacing HPLC to FTIR and MALDI-MS.

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Technological expertise: CH/S, R Principal products/instrumentation: LCTransform™ 400 series for FTIR 96; LCTransform™ 500 series for MALDI-MS97. Main products/instrumentation under R&D: Laboratory professional instruments for interfacing HPLC to FTIR and MALDI-MS.

1654

LAB-LINE INSTRUMENTS, IMC.

Add: 15th and Bloomingdale Ave. Melrose Park, IL 60160

R&D expertise: R&D, manufacture/marketing of laboratory automation instrumentation — custom turnkey systems and robotics. Technological expertise: CH/S, HTDS, PMC, R Principal products/instrumentation: HTS Replicators, Microarray Spotters, Weighing and labeling systems, Powder dispensing systems. Main products/instrumentation under R&D: Laboratory automation instruments, including custom turnkey systems, robotics, etc. Subsidiary bodies: ISO 9001.

Tel: (708) 450-2600 Fax: (708) 450-0943

1656

LABMATE (ASIA) PVT, LTD.

Web site: www.labline.com President/CEO: Mark A. Newman Research director: Deb Searles R&D expertise: Development and manufacture of laboratory biomedical equipment for pharmaceutical research.

Add: SF-1, Lokesh Towers, 18 Kodambakkam High Road Chennai, Tamil Nadu 600 034 India Tel: (44) 2220-0066 Fax: (44) 2220-0056 E-mail: [email protected]

Technological expertise: BME

Web site: www.labmateasia.com

Principal products/instrumentation: Constant temperature equipment, featuring environmental chambers, furnaces, heaters, mixers, stirrers, shakers, clamps, jacks, incubators, refrigerators and freezers.

Research director: S. Kumar

Main products/instrumentation under R&D: Professional laboratory equipment for pharmaceutical research.

Technological expertise: BA, C/TC, GA, H/CF, P/S

1655

LABMAN AUTOMATION, LTD.

Add: Stokesley Industrial Park Stokesley, North Yorkshire TS9 5JZ U.K. Tel: (44) 1642-710-580

R&D expertise: Development, manufacture and marketing of up-stream, down-stream and other related novel products in molecular biology and microbiology.

Principal products/instrumentation: Organ transplants/culture, pharmaceuticals, process validation, vaccines, veterinary fermentors, thermal cyclers, electroporation. Main products/instrumentation under R&D: Molecular biology and microbiology development products, including up-stream expressing sequence, down-stream processing, etc.

Fax: (44) 1642-710-667 E-mail: [email protected] Web site: www.labman.co.uk President/CEO: Andrew Whitwell Research director: Peter Cooper

1657

LABMETOD, OY.

Add: Myllypadont 16 E Helsinki 00920 Finland

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complete gel casting set for quick gel preparation, 2009.

E-mail: [email protected] Web site: www.labmetod.com

1659

LABORATOIRES EUROBIO

President/CEO: Vesa Urtela R&D expertise: Development, manufacture and supply of biomedical laboratory equipment and labwares.

Tel: (33) 1-6907-9477 Fax: (33) 1-6907-9534 E-mail: [email protected]

Technological expertise: E, P/S, C/TC, COC, GA

Web site: www.eurobio.fr

Principal products/instrumentation: PCR equipment, Hybaid; CO2 incubators, microbiology analyzer, test reagents, microscopes.

Research director: Patrice Sarfati

Subsidiary bodies: Moscow, Russia.

1658

LABNET INTERNATIONAL

Add: P.O. Box 841 Woodbridge, NJ 07095 Tel: (732) 417-0700 Fax: (732) 417-1750 E-mail: [email protected] Web site: www.labnetlink.com President/CEO: Gerard Cooney C Research director: Michael Rosenblum R&D expertise: Manufacture and marketing of lab/molecular biology products to research/clinical marketplace. Technological expertise: BME,P/S Principal products/instrumentation: Hermle™ Centrifuges, Labnet™ pipets, incubators, shakers, rockers, Gel Dryer, DNA vap centrifugal evaporator, electrophoresis products, plastics; Spectrafuge 24D Microcentrifuge Starter pack, a complete micro-centrifugation package, including all the tools necessary for microsample separation, 2007; DNA and RNA Separation: The Enduro Gel XL™ is a system for nucleic acid (DNA and RNA) separation in agarose gels. The system includes a programmable power supply, gel running tank, and a

President/CEO: Stephane Reveilleau R&D expertise: R&D and manufacture of tissue and cell culture media, human blood typing sera, HLA sera; molecular biology reagents and cells for viral diagnostic. Technological expertise: CC, E, PA, F, RD, PMC, AB, C/TC, GA, H/CF, P/S Principal products/instrumentation: Tissue culture media; Bacteriological and viral reagents; Cells for diagnostic; Antisera for bacteria; Serotyping, including antisera for human blood cells typing; HLA antisera. Main products/instrumentation under R&D: P53 antibodies EIA test using patented peptides. Chemiluminescent reporter group luminarine for antisera, origo labeling, molecular biology reagents, p53 peptides, color substrate for bacteria testing. Subsidiary bodies: Toulouse, France. Sealed and granted patents: Luminarine®, p53 Peptides, color substrate for bacteria testing.

1660

LABODIA, SA.

Add: Case Postale 48, Chanta-Merloz, CH1169 Yens Switzerland Tel: (41) 21-800-4384 Fax: (41) 21-800-3449 E-mail: [email protected] Web site: www.labodia.com

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President: Luc Binet R&D expertise: Development and manufacture of clinical diagnostic drugs. Technological expertise: P/S Principal products/instrumentation: Lyme Immunoblots, Orbit. Main products/instrumentation under R&D: Novel clinical diagnostic drugs.

R&D collaboration: Lifecodes Corp., Stamford, CT. Technological expertise: E, RD, P/S, H/CF, C/TC, CH/S Main products/instrumentation under R&D: Diagnostic kits for infectious diseases; identification systems for humans and animals.

1663 1661

LABOMED, INC.

LABORATORY CORPORATION OF AMERICA

Add: 2921 S. La Cienega Blvd. Ste. A Culver City, CA 90232

Add: P.O. Box 2230 Burlington, NC 27215

Tel: (310) 202-0814

Fax: (910) 513-4121

Fax: (310) 202-7286

Web site: www.labcorp.com

E-mail: [email protected]

President/CEO: James Powell, M.D.

Web site: www.labomed.com

Research director: Gail Page

President/CEO: Jack Barker

R&D expertise: Clinical laboratory research services, genetic testing, forensic identity.

Research director: Jack Barker R&D expertise: Development and manufacturing of biomedical laboratory research equipment/instrumentation. Technological expertise: CC, BI, BS, CB, HTDS, PG Principal products/instrumentation: Spectro 22 & 22RS Digital Spectrophotometer, Spectro 2000 RS Spectrophotometer, Spectro 2000 RSP Spectrophotometer, Spectro UV-VIS RS Spectrophotometer.

Tel: (910) 229-1127

Technological expertise: E, PA, C/TC, CH/S, GA, HTDS, H/CF, P/S, RD Principal products/instrumentation: Clinical tests, contract research/clinical trial products, diagnostics, in vitro toxicology testing, reagents, veterinary drug, gene vaccines. Main products/instrumentation under R&D: Forensic identification, genetic testing.

1664 1662

LABORATORIES CO., LTD. (IBL) IMMUNOCARE CANADA, INC.

LABORATORY SUPPLIES CO., INC.

Add: 29 Jefry Lane Hicksville, NY 11801

Add: 5201 Rosedale Ave. Montreal, Quebec H4V 2H4 Canada

Tel: (516) 681-7711

Tel: (514) 486-9583

President/CEO: S. Berman

Fax: (514) 486-7185

R&D expertise: Development and manufacture of ultrasonication and related products.

President/CEO: A. M. Francoeur, Ph.D. R&D expertise: R&D consulting services and development of diagnostics for autoimmune diseases.

Web site: www.labsupplies.jimlemire.com

Technological expertise: DD Principal products/instrumentation: Ultrasonic cleaner, ultrasonic cleaning solution,

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ultrasonic disintegrator, ultrasonic generator, ultrasonic homogenizer, ultrasonic cell disintegrator, fluorescent light boxes.

1665

LABOR DR. KOCH-DR. MERK

515

R&D expertise: Development and manufacture of biomedical laboratory automation software. Technological expertise: CH/SS Principal products/instrumentation: SampleManager LIMS, Nautilus LIMS, Atlas, CDS. Subsidiary bodies: International

Add: Beim Braunland 1 Ochsenhausen D-88416 Germany Tel: (49) 23-523-400 Fax: (49) 73-524-834

1667

LABSYSTEMS AFFINITY SENSORS

E-mail: [email protected]

Add: Saxon Way, Bar Hill Cambridge CB3 GSL U.K.

Web site: www.laborDrKochDrMerk.de

Tel: (44) 1954 789976

President/CEO: Dr. Merk

Fax: (44) 1954 789417

Research director: Dr. Jungnol Ramp/ Dr. W. Dangel

E-mail: [email protected]

R&D expertise: Development and manufacture of diagnostics in infectious diseases; biotechnology medicines research; propagation of virus-antigens.

President/CEO: Carl Jones

R&D collaboration: University of Heidelberg and Ulan Virim, Switzerland.

R&D expertise: Research and manufacture of scientific instrumentation.

Technological expertise: F, P/S, C/TC

Technological expertise: E, F, PA, BA, CB, D-D, PMC

Principal products/instrumentation: In vitro toxicology testing method, diagnostic products for infectious diseases and diabetes. Main products/instrumentation under R&D: Biotech medicines, biotechwares, propagation of virus-antigens.

1666

LABSYSTEMS

Add: St. Georges Court Hanover Business Park Altrincham, Cheshire WA14 5TP U.K. Tel: (44) 161-942-3000

Web site: www.affinity-sensors.com Research director: Paul Edwards Subsidiary of Thermo Electron.

Principal products/instrumentation: Manual Optical Biosensor, Automated Optical Biosensor. Main products/instrumentation under R&D: Resonant mirror biosensor, new scientific instruments. Subsidiary bodies: Affinity Sensors, 53 West Century Rd., Paramus, NT 07652, U.S.A., Tel: (201) 986 1020 or (800) 631-1369; Fax: (201) 265-1977. Sealed and granted patents: Resonant mirror biosensor; other patents pending.

Fax: (44) 161-942-3001 E-mail: [email protected] Web site: www.thermo.com President/CEO: Gordon Logan

1668

LABTECH INTERNATIONAL, LTD.

Research director: Kevin Smith

Add: 1 Acorn House, The Broyle Ringmer, East Sussex, BN8 5NN, U.K.

Subsidiary of Thermo Johnson.

Tel: (44) 1273-814-888

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Fax: (44) 1273-814-999

Web site: www.labtronics.com

E-mail: [email protected]

President/CEO: Robert Pavlis

Web site: www.labtech.co.uk

Research director: Alan Vemon

President/CEO: Brian Page

R&D expertise: Develop biotechnological scientific software and instrument control systems for laboratories.

R&D expertise: Manufacture and supply of professional products in cell biology, molecular biology, microplate technology, luminescence and niche technical markets. Technological expertise: C/TC, CH/S Principal products/instrumentation: Luminescent ATP kits, Luciferase reporter gene assays.

1669

LABTEK SRL EUROBIO

Add: Viale Italia, 12 Corsico (Milano) 20094 Italy

Technological expertise: COC, CH/S, R Principal products/instrumentation: LimsLink; BalanceTalk; MagicChem; Automated microplate analyzer, an economical integrated analytical system for sample preparation and microplate analysis; pipette Tracker software, automating gravimetric pipette calibration and record keeping by tracking and scheduling pipette calibration, automating data collection, performing all calculations, and producing required reports.

Tel: (39) 2-440-4625 Fax: (39) 2-440-2535

1671

LAB VISION CORPORATION

President/CEO: Stephen Reveilleau R&D expertise: Development and manufacture of reagents for biotechnology and diagnostics.

Add: 453600 Westinghouse Dr. Fremont, CA 94539 Tel: (510) 771-1560

Joint ventures: Branch of Laboratories Eurobio — France.

Fax: (510) 771-1570

Technological expertise: C/TC

Web site: www.labvision.com

Principal products/instrumentation: Cellular and molecular biology reagents, immunology vector products.

President/CEO: Glenn Takayama

Main products/instrumentation under R&D: Kits for veterinary, reagents for biotechnology.

1670

LABTRONICS, INC.

Add: 546 Governor’s Road Guelph, ON NIK 1E3 Canada Tel: (519) 767-1061 Fax: (519) 836-4431 E-mail: [email protected], support@ labtronics.com

E-mail: [email protected]

Research director: Atul Tandon, Ph.D. R&D expertise: R&D, manufacture/supply of biotech instruments, antibodies and reagents for cancer research and tumor classification, imaging devices, etc. Key sales market contracts: Exclusive distributor of NEOMARKERS™ primary antibodies. Technological expertise: PA, P/S, C/TC, CH/S, H/CF Principal products/instrumentation: Contract manufacturing products, diagnostics, instruments, reagents and antibodies for cancer research and tumor classification; NEOMARKERS™, automated immunohistochemical staining device.

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Main products/instrumentation under R&D: Telepathology, enzymatic immunodetection, special reagents for immunohistochemistry, biotech instruments.

1672

LA JOLLA DIAGNOSTICS, INC.

Add: 1020 Prospect St. Suite 210 La Joila, CA 92037 Tel: (800) 454-6790 Fax: (619) 454-7851 President/CEO: Don Brucker Research director: Don Brucker R&D expertise: Development of polyclonal antibodies and gene amplification, related novel products manufacture. Technological expertise: PA, GA

517

Main products/instrumentation under R&D: Antibody toleragens to treat lupus, Phase III clinical trials; Rh hemolytic disease of the newborn, R&D; Graves disease, R&D; recurrent stroke, R&D; PLAZ inhibitors to treat inflammation, R&D; polypeptides. Sealed and granted patents: Therapeutic and diagnostic domain 1 beta. 2GPI polypeptides and methods of using same, 6858210, U.S.; Conjugates comprising alpha 1,3galactosyl epitopes and methods of using the same. 6399578, U.S.; Methods of treating lupus based on antibody affinity and screening methods and compositions for best thereof. 7081242, U.S.; other patents are pending.

1674

L’ALLIANCE BOVITEQ, INC.

Principal products/instrumentation: Feverfew Nasal Mist, Living Water Eye Lotion, Optopet Eye Wash.

Add: 1425 Grand Rang St-Francois SaintHyacinthe, Quebec J2S 7A9 Canada

Main products/instrumentation under R&D: Polyclonal antibodies, gene amplification, gene therapy, gene transduction technique.

Fax: (450) 774-1740

Tel: (450) 774-7949 E-mail: [email protected] Web site: www.boviteq.com

1673

LA JOLLA PHARMACEUTICAL CO.

President/CEO: Dr. Wilffied Holtmann Research director: Daniel Bousquet, D.M.V., Ph.D.

Add: 6455 Nancy Ridge Dr. San Diego, CA 92121

R&D expertise: Development, manufacture and commercialization of frozen bovine embryos.

Tel: (858) 452-6600

Technological expertise: C/TC, GA

Fax: (858) 626-2851

Principal products/instrumentation: Frozen bovine embryos, frozen bovine embryos transfer technique.

Web site: www.ljpc.com President/CEO: Steven Engle Research director: Stephen Coutts, Ph.D. R&D expertise: R&D/manufacture of therapeutic products to treat antibody mediated disease and inflammation. Technological expertise: Q, PB, RD, P/S, C/TC, SY, COC Principal products/instrumentation: LJP394 for lupus.

Main products/instrumentation under R&D: IVF-produced embryos, frozen bovine sexed embryos.

1675

LAMPIRE BIOLOGICAL LABORATORIES, INC.

Add: P.O. Box 270 Pipersville, PA 18947

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Tel: (215) 795-2838

1677

Fax: (215) 795-0237

LAPID PHARMACEUTICALS, LTD.

E-mail: [email protected] Web site: www.lampire.com President/CEO: Gregory F. Krug R&D expertise: Several antibodies production technique, animal blood products and immunochemistry contract research.

Add: 2 Pekeris St. Tamar Park Rehovot 76702 Israel Tel: (972) 8-936-1575 Fax: (972) 8-936-1570 E-mail: [email protected]

Technological expertise: PA, BA, C/TC, H/CF

Web site: www.lapidpharma.com

Principal products/instrumentation: Contract manufacturing products, contract Bioreactor, antibodies, animal blood products; Cell Culture Bags: These cell culture bags offer an alternative approach to growing cells. The bags are offered in 1 L, 2 L, 50 mL, 100 mL, and 250 mL sizes. The bags have a new port design that fills and harvests cells. The cell culture bags grow hybridoma cells for antibody production, mammalian cells, epithelial cells, stem cells, tumor cells, fibroblasts, plant cells, and work for recombinant protein production and DNA/RNA extraction. Cell cultures may be grown in a CO2 incubator utilizing desired cells and the appropriate media formulation, 2009.

R&D expertise: Drug discovery, drug research, drug design, drug delivery and development/ manufacture.

1676

LANCER INDUSTRIE

President/CEO: Stanley Fass

Technological expertise: DD, D-D, DDI Main products/instrumentation under R&D: Antidiabetic agents, preclinical; improved drugs, antidiabetic drug, analgetic, anti-cancer, cytokines, including interferon, interleukin, tumor necrosis factor, thrombopoietin, growth factors, rhGM-CSF, etc.

1678

LARGE SCALE BIOLOGY CORP.

Add: 9620 Medical Center Dr. Rockville, MD 20850 Tel: (301) 424-5989 Fax: (301) 762-4892

Add: ZI Pahin 30 Bd de L’Industrie Tournefeuille 31170 France

E-mail: [email protected]

Tel: (33) 561-151-111

Research director: Norman G. Anderson, Ph.D.

Fax: (33) 561-151-616 E-mail: [email protected] Web site: www.lancer.fr President/CEO: C Hammer Research director: J. M. Brieussel R&D expertise: Development and manufacture of washers for labware/industry equipment Technological expertise: BME Principal products/instrumentation: Labware washer, washer for industry equipment.

President/CEO: N. Leigh Anderson, Ph.D.

R&D expertise: 2-D protein mapping contract research and services; protein informatics development derived from 2-D electrophoresis; related novel products manufacture. R&D collaboration: NIH SBIRs, instrumentation development, NIST ATP. Technological expertise: BI, PS/AP Principal products/instrumentation: 2-D electrophoresis drug effects databases; contract studies using 2DE, protein pharmaceuticals.

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1679

LARGE SCALE BIOLOGY CORPORATION

Add: 3333 Vaca Valley Pkwy. Ste. 1000 Vacaville, CA 95688 Tel: (707) 446-5501

519

Technological expertise: BA, F Principal products/instrumentation: Ethanol, vegetable proteins, vegetable drugs, vegetable mucin. Main products/instrumentation under R&D: Fermented nutrient drug

Fax: (707) 446-3917 E-mail: [email protected]

1681

LARK TECHNOLOGIES, INC.

President/CEO: Robert Erwin Research director: Laurence K. Grill, Ph.D. R&D expertise: Discovery, design, development and manufacture of complex biochemical products; functional genomics, proteomics and antigenics. R&D collaboration: Dow Chemical, Dow Agro Sciences, GlaxoWellcome, Procter & Gamble. Technological expertise: AB, BA, BS, E, F, Q, T, GA, GT, G, PB, P/S, RD Principal products/instrumentation: GENEWARE® gene expression system, Progex® proteomics. Main products/instrumentation under R&D: Anti-infectives, preclinical; oncology therapeutics, preclinical. Subsidiary bodies: Owensboro, KY, large-scale pilot plant, large-scale biology-proteomics. Sealed and granted patents: Geneware, antiinfectives, oncology, proteomics; other patents pending.

1680

LARKSPUR CORP.

Add: 9441 W. Sam Houston Parkway South, Ste. 103 Houston, TX 77099 Tel: (713) 779-3663 Fax: (713) 779-1661 E-mail: [email protected] Web site: www.lark.com President/CEO: Doug Wheeler Research director: J. D. Kittle R&D expertise: Nucleic acid analysis and new products development under GLP guidelines; contract novel drug research/development organization, DNA sequencing, QPCR contract research development organization. Technological expertise: T, Q, GA, GT, G, BI, RD, PG Principal products/instrumentation: Human genome project, nucleic acid sequence analysis, DNA sequencing service; genetic testing, microarray support services. Main products/instrumentation under R&D: Microarray analysis, DNA sequencing QPCR contract research products. Subsidiary bodies: Saffron Walden, U.K.

Add: P.O. Box 170380 Milwaukee, WI 53217 Tel: (941) 572-3703

1682

LAROVA BIOCHEMIE GMBH

Fax: (414) 355-1844 President/CEO: Melvin Bernstein R&D expertise: Drug coproduct utilization development, fermentation nutrient consulting, ethanol marketing.

Add: Kantstrasse 55 Teltow D-14513 Germany Tel: (49) 3328-395-638 Fax: (49) 3328-395-639 E-mail: [email protected]

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Web site: www.larova.com

1684

LASER SCIENCE, INC.

President/CEO: Roxana Havlina Research director: Roxana Havlina

Add: 8E Forge Parkway Franklin, MA 02038

R&D expertise: Research of enzymology and enzymetic technique, enzymatic synthesis of oligonucleotides, related novel products manufacture.

Tel: (508) 553-2391

Technological expertise: CC, E, F, AB, BA, GA, P/S, SY Principal products/instrumentation: Ultrapure dNTPs, dNTP sets, dNTP mixes, bulk dNTP product, PCR kits, RT-PCR kits, Dnase 1 footprinting kits, sequencing sets, sequencing primer. Main products/instrumentation under R&D: Enzymatic synthesis of chirally pure phosphorothioate oligonucleotides, enzymatic synthesis of oligonucleotides for diagnostic market, polymers, enzymatic method for synthesis of fntisense oligonucleptides. Sealed and granted patents: WO09967413AI Production of polymers from nucleotidic and/or non-nucleotidic elements using enzymatic methods; other patents pending.

Fax: (508) 553-2355 E-mail: [email protected] Web site: www.laserscience.com President/CEO: Zach Moseley Subsidiary of Thermo Instruments. R&D expertise: Development, design, manufacture and marketing of lasers used in fluorescence, microablation and MALDI-TOF mass spectrometry, microdissection, biological screening, and many other applications.. Technological expertise: AMS,FL Principal products/instrumentation: Nitrogen lasers, dye lasers, CO2 lasers. Main products/instrumentation under R&D: Lasers used in fluorescence, microablation and MALDI-TOF mass spectrometry, laser microprobe.

1685 1683

LASENTEC

LAYTON BIOSCIENCE, INC.

Add: 709 East Evelyn Ave. Sunnyvale, CA 95086

Add: 15224 NE 95th St. Redmond, WA 98052

Tel: (408) 732-5050

Tel: (425) 881-7117

Fax: (408) 732-5090

Fax: (425) 881-8964

Web site: www.laytonbio.com

E-mail: [email protected]

President/CEO: Gary L. Snable

Web site: www.lasentec.com

Research director: Michael McGrogan, Ph.D.

Research director: Jon Hokanson

R&D expertise: Research and products manufacture of neuroscience, human neural ECUS, Nicotine receptor antagonists.

R&D expertise: Development of in-reactor cell count, cell size, cell differentiation, cell cycle control, video imaging instrumentation. Technological expertise: PMC Principal products/instrumentation: In-reactor cell counter, imaging instruments. Main products/instrumentation under R&D: Video imaging instruments, cell cycle controller.

Technological expertise: C/TC, GA Principal products/instrumentation: LBSNeurons. Main products/instrumentation under R&D: LBS-Neuron™, clinical; Inversine®, preclinical; nicotine receptor antagonists.

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1686

LAZAR RESEARCH LABORATORIES, INC.

Add: 731 N. La Brea Ave., Suite 5 Los Angeles, CA 90038-3338

521

Subsidiary bodies: PCR diagnostic kit, manufacture facilities in Shanghai, P. R. China. Sealed and granted patents: 982042881 P. R. China

Tel: (323) 931-1433 Fax: (323) 931-1434 E-mail: [email protected]

1688

LDS TECHNOLOGIES, INC.

Web site: www.lazarlab.com

Add: 305 Chelsea Parkway Boothwyn, PA 19061

President/CEO: Dan Altura, Ph.D.

Tel: (610) 485-6100

Research director: Dan Altura, Ph.D.

Fax: (610) 485-6121

R&D expertise: Manufacturing and marketing of electrodes and chromatography equipment for drug research.

President/CEO: Christopher R. Lientz

Technological expertise: C/TC, PMC Principal products/instrumentation: Ultra M micro combination pH electrode (PHR-146). Main products/instrumentation under R&D: Electrodes and chromatography equipment for drug research.

1687

LC INTERNATIONAL

Add: 18 East 48th Street New York, NY 10017 Tel: (212) 688-1198 Fax: (212) 688-2325 E-mail: [email protected] Web site: www.lcidiamonds.com President: Dao P. Huang Research director: Dao P. Huang R&D expertise: Development/manufacture/ marketing of medical diagnostic reagents. Joint ventures: Jin Jas Group Co., Shanghai, China.

Research director: Carey B. Bottom, COO R&D expertise: Development/manufacture of LDS — microemulsion-based drug delivery systems for oral, intravenous and inhalation delivery. Key license and trade contracts: Ferring AB, a Swedish pharmaceutical company, for the development of an oral delivery formulation of a peptide using LDS’s microemulsion technology. Technological expertise: D-D Main products/instrumentation under R&D: An oral peptide using LDS’s microemulsion technology, microemulsion-based drug delivery systems. Sealed and granted patents: LDS’s U.S. Patent #5,444,041: Convertible Microemulsion Formulations, issued on 22 August 1995. This patent was published by the PCX as W092/ 18147. LDS is pursuing the patent in the EPO and elsewhere.

1689

LEAP TECHNOLOGIES

Technological expertise: GA Principal products/instrumentation: HBV PCR quantitative kit. Main products/instrumentation under R&D: PCR diagnostic kits, medical diagnostic reagents.

Add: P.O. BOX 969 Carrboro, NC 27510 Tel: (919) 929-8814 Fax: (919) 929-8956 E-mail: [email protected]

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Web site: www.leaptec.com President/CEO: Werner Martin

Sealed and granted patents: C. difficile toxin A purification method.

Research director: Sal Salguero R&D expertise: Development/manufacture of laboratory biomedical research automation equipment specifically in sample prep and loading for chromatography and mass spectroscopy; also dissolution testing automation for pharmaceutical industry.

Add: 2924 Mary Av. St. Louis, MO 63144

Technological expertise: BME, HTDS

Web site: www.leescientific.com

R&D collaboration: CTC Analytics.

President/CEO: Burton Lee

Key sales market contracts: LINC Quantum, Cohesive Technologies, Shimadzu Instr.

Research director: Richard Supanich

Principal products/instrumentation: High throughput LC-TLS sample Processor, GCHeadspace sample processor, Compact LC sample processor, Fiber Optic dissolution tester.

1691

LEE SCIENTIFIC, INC.

Tel: (314) 968-1091 Fax: (314) 968-9851

R&D expertise: Development and manufacture of purified enzymes, antigens and related purified proteins for clinical and immunodiagnostics, and of peptide coupling reagents and protecting for peptide synthesis. Technological expertise: E, P/S, PB

1690

LEE LABORATORIES

Add: 1475 Athens Highway Grayson, GA 30221 Tel: (770) 972-4450 Fax: (770) 979-9570 E-mail: [email protected]

Principal products/instrumentation: Contract manufacturing products, AFP, CK-MB, LDH, g6T, AST, ALT, Amylase, Lipase, ALP, CK, GLDH, SSPPS-products; HBTU, TBTU, FMOC, ONSU, HOBT. Main products/instrumentation under R&D: Peptide coupling reagents, purified enzymes, purified proteins.

Web site: www.leelabs.com President/CEO: J. Douglas Guthrie, Jr.

1692

LEICA MICROSYSTEMS, INC.

Research director: John Deutsch Subsidiary of Becton Dickinson Microbiology Systems.

Add: 1 1 1 Deer Lake Rd. Deerfield, IL 60015

R&D expertise: Development and manufacture of in vitro diagnostics — infectious disease test reagents.

Fax: (847) 405-0147

Technological expertise: F, PA, P/S Principal products/instrumentation: Tpure™ (purified syphilis antigen), syphiligen recombinant T.P. Antigen. Main products/instrumentation under R&D: C. difficile toxin A purification method, infectious disease test reagents.

Tel: (800) 248-0123 E-mail: [email protected] Web site: www.leica-microsystems.com President/CEO: Henry B. Smith III R&D expertise: Manufacture and supply of microscopes and scientific instruments. Technological expertise: BME Principal products/instrumentation: Microscope condenser, contract manufacturing

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products, DM IRB inverted microscope, Q600 image processing and analysis system, MZFLIII stereomicroscope with fluorescence module, DM R research microscopes, DM RXA automated microscope system used for FISH analysis.

1694

523

LEONARD SPEISMAN, PHD

Add: 19383 SW 103 Court Miami, FL 33173 Tel: (305) 271-7300 E-mail: [email protected] President/CEO: Leonard Speisman

1693

LEIVAS LEITE S/A — INDUSTRIAS QUIMICAS/ E BIOLOGICAS

Add: Benjamin Constant, 1637 Pelotas, R.G. do Sul 96010-020 Brazil Tel: (532) 253-666

R&D expertise: Genomics research, related novel biotechnology medicines development. Technological expertise: G Principal products/instrumentation: Human genome project, biopharmaceuticals. Main products/instrumentation under R&D: Genomic DNA, genomic fingerprinting.

Fax: (532) 273-286 President/CEO: Pedro Antonio Leivas Leite, Ph.D.

1695

LEUKOSITE, INC.

Research director: Fabio Pereira Leivas Leite, D.V.M.

Add: 215 First St. Cambridge, MA 02142

R&D expertise: Development, manufacture and commercialization of veterinary and agricultural products.

Fax: (617) 621-9349

R&D collaboration: Empresa Brasileira de Pesquisa Agropecuaria, Universidade Federal de Pelotase Fundacao, Universidade de Caxias do Sul, Universidade Federal de Santa Maria, RS. Key license and trade contracts: Vetrepharm Laboratories. Technological expertise: F, E, BA, C/TC, SY, D-D, DD Principal products/instrumentation: Ciclosom injection for parasites of cattle, sheeps, pigs; Era-Vac vaccine antirabic for cattle, equine, dogs, sheep; Calfomag injection for rickets, milk fever, eclampsia, urticaria; vaccine for anthrax or splenic fever; nitrogen inoculant for leguminosae. Main products/instrumentation under R&D: Vaccine for equine herpes, in registration at ministry of agriculture; vaccine for equine influenza; diagnostic kits for swine and pets, pre-industrial stages.

Tel: (617) 621-9350 E-mail: [email protected] President/CEO: Christopher K. Mirabelli Research director: Walter Newman R&D expertise: Research, development, manufacture and commercialization of novel treatment drugs for inflammatory and autoimmune diseases. R&D collaboration: Warner-Lambert, ParkeDavis Key license and trade contracts: CD18, Beta-7 (antibodies). Technological expertise: Q, BA, C/TC, MAE, D-D, HTDS, H/CF, PB, P/S, RD, SMC, SY Main products/instrumentation under R&D: CD 18 monoclonal antibody, preclinical; Beta7 monoclonal antibody, preclinical; MCP-1 receptor antagonist, R&D; Beta-7/MadCAM small molecule antagonist, R&D; Eosinophil chemokine receptor antagonist, R&D. Sealed and granted patents: Multiple U.S. and European patents applications filed.

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LEXICON GENETICS, INC.

Genome Research Inst. — large-scale analysis of gene function using Lexicon’s OmniBank.

Add: 8800 Technology Forest Place The Woodlands, TX 77381

Technological expertise: Q, T, BI, GA, RD, SMC, G

Tel: (281) 863-3000

Principal products/instrumentation: Program in homologous recombination (research collaborations); OmniBank, a database of gene function, high throughput gene trapping technology.

Fax: (281) 863-8088 E-mail: [email protected] Web site: www.lexicon-genetics.com President/CEO: Arthur T. Sands, M.D., Ph.D. Research director: Brian Zambrowicz, Ph.D. R&D expertise: R&D functions of genes for drug discovery using large-scale functional genomics technologies; invention of high throughput gene trapping technology that enabled the genome-wide alteration of genes in mouse embryonic stem (ES) cells to generate mice for functional genomics studies on an unprecedented scale. In mice, each disrupted gene enables the discovery of its in vivo function using a sophisticated series of medical tests as an assay for drug discovery. This gene trapping technology also enabled Lexicon scientist to simultaneously obtain DNA sequences of genes from human and mouse genomes. Using this high throughput gene trapping technology leads to discovery of thousands of novel genes, physiological functions defining LexVision™ drug discovery program. R&D collaboration: Established drug discovery collaborations with Abgenix, Inc. and Arena Pharmaceuticals, and functional genomics and OmniBank alliances with American Home Products, The R.W. Johnson Pharmaceutical Research Institute of Johnson & Johnson, Pharmacia Corp., Boehringer Ingelheim, N.V Organon, DuPont Pharmaceuticals and Millennium Pharmaceuticals as well as leading academic institutions worldwide. Key license and trade contracts: Baylor College of Medicine — exclusive gene targeting and ES cell technology; GenPharm — exclusive licensee, positive-negative selection; MIT — exclusive gene trapping; Merck

Main products/instrumentation under R&D: OmniBank™, Human Gene Trap™, database; homologous protein.

1697

LGC

Add: Queens Rd. Teddington TW11 OLY U.K. Tel: (44) 20-8943-7357 Fax: (44) 20-8943-2767 E-mail: [email protected] Web site: www.lgc.co.uk CEO: R. Worswick Research director: D. Craston/Hellen Pannes R&D expertise: R&D of analytical chemistry/ biology; related novel products, manufacture. Joint ventures: Pharmacogenetics. Technological expertise: P/S, AB, C/TC, G, PG, PMC Principal products/instrumentation: Pharmacogenetics profiling; DNA profiling; assay development, pharmagenomics profiling. Main products/instrumentation under R&D: Analytical biochemistry reagents.

1698

LG CHEMICAL COMPANY

Add: 20 Youido-dong, Yongdungpo-gu Seoul 150 South Korea Tel: (82) 2-3773-1114 Fax: (82) 2-3773-5446 Web site: www.lgchem.com

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President/CEO: Jae Kap Sung R&D expertise: R&D/manufacture of vaccines, hormone and other biotechnology medicines.

1700

525

LI-COR, INC.

Add: 4308 Progressive Ave. P.O. Box 4000 Lincoln, NE 68504

Key license and trade contracts: SmithKline Beecham LB 20304A or SB 265805), ParkeDavis (LB 30057), Merck KGaA (Biopharmaceuticals).

Tel: (402) 467-3576

Technological expertise: E, F, Q, RD, SY, T, BA, C/TC, COC, CH/S, DD, D-D, GA, HTDS, PB, P/S

Web site: www.licor.com

Principal products/instrumentation: HBV vaccine, Ubax; HCV diagnostics, HCD; Bovine Somatotropin, Boostin; Human Growth Hormone, Utropin.

R&D expertise: R&D/manufacture of biomedical instrumentation for biological and environmental biology research.

Main products/instrumentation under R&D: Quinolone antibiotics, Phase III; Thrombin inhibitor, preclinical; HIV protease inhibitor, preclinical; HCV Vaccine, preclinical; aminopeptidase, peptide hormone.

Principal products/instrumentation: IR (2) System automated DNA sequencers, instruments for biotech drugs research, reagents, human genome program.

Sealed and granted patents: Aminopeptidase derived from Bacillus licheniformis and process for preparation of natural type proteins. 6,428,997, U.S.

1699

Fax: (402) 467-2819 E-mail: [email protected] President/CEO: William W. Biggs Research director: Lyle R. Middendorf

Technological expertise: Q, BME

Main products/instrumentation under R&D: Apparatus for nucleic acid sequencing. Sealed and granted patents: System and apparatus for nucleic acid sequencing of single molecules by polymerase synthesis. 6,762,048, U.S.

LIBERTY INDUSTRY, INC.

Add: 133 Commerce St. East Berlin, CA 00023 Tel: (800) 828-5656 Fax: (800) 828-8879 E-mail: [email protected] Web site: www.liberty-ind.com President/CEO: Bob Kaiser R&D expertise: Development and manufacture of clean room and accessories laminar flow. Technological expertise: BME Principal products/instrumentation: Tacky mats, laminar flow, shoe brush, clean room air shower, clean room, accessories laminar flow.

1701

LIFECELL CORPORATION

Add: 3606 Research Forest Dr. The Woodlands, TX 77381 Tel: (281) 367-5368 Fax: (281) 363-3350 Web site: www.lifecell.com President/CEO: Paul Frison C Research director: Stephen A. Livesey R&D expertise: Medical products development and manufacture. Key license and trade contracts: Medtronic, Inc. — heart valves. Technological expertise: C, TE, C/TC

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Principal products/instrumentation: Biologicals, biomaterials, AlloDerm® Accelular Dermal Graft, ThromboSol, heart valves.

1703

LIFE MEDICAL SCIENCES, INC.

Add: 379 Thornall St. Edison, NJ 08837

Main products/instrumentation under R&D: ThromboSol™ Platelet Storage Solution, preclinical; LifeCell® Heart Valve, preclinical; Universal Vascular Conduits, preclinical.

Tel: (908) 494-0444

Sealed and granted patents: 5,336,616.

President: Robert Hickey

Fax: (908) 494-6252 Web site: www.lifemed.com Research director: Eli Pines, Ph.D.

1702

LIFECODES CORP.

R&D expertise: Development/manufacture of in-situ tissue culturing and polymer systems for drug delivery/therapeutic purposes.

Add: 550 West Ave. Stamford, CT 06902

Technological expertise: TE, C/TC

Tel: (203) 328-9500

Principal products/instrumentation: SkarKare™, Sure-Closure™.

Fax: (203) 328-9599 President/CEO: Walter O. Fredericks Research director: Ivan Balazs, Ph.D. R&D expertise: Development, manufacture and marketing of DNA probes and related products for human identity testing and HLA DNA typing. R&D collaboration: Molecular Dynamics. Key sales market contracts: Amersham Life Sciences; Molecular Innovations. Key license and trade contracts: University of Utah, Roche Molecular Systems, PerkinElmer Applied Biosystems, University of Oklahoma.

Main products/instrumentation under R&D: Cariel, Phase IIIa; Piliel, Phase IIIa; Repel, Pilot clinical; in situ tissue culturing systems, drug polymer systems.

1704

LIFE SCIENCE RESOURCES

Add: Abberley House, Granhams Rd. Great Shelford Cambridge CB2 5LQ U.K. Tel: (44) 122-384-5836 Fax: (44) 122-384-0342 E-mail: [email protected] President/CEO: Dr. W. Henderson

Technological expertise: Q, RD, GA, SY

Research director: Dr. T. McCann

Principal products/instrumentation: Biologicals, diagnostics, clinical tests, QuickLight™ identity kits and hybridization kits; Quick-Type™ products for identity testing of amplified DNA and molecular HLA typing.

R&D expertise: Development and manufacture of drug screening and related instruments for biotechnology industry.

Main products/instrumentation under R&D: Life codes Microarray system, DNA probes, human identity testing. Subsidiary bodies: Michigan, Tennessee, Vancouver, Germany. Sealed and granted patents: Glassberg.

Technological expertise: C, S, P/S, C/TC, CH/S Main products/instrumentation under R&D: Fluorescent gel imager, drug lead devices, drug screening instruments.

1705

LIFE SCIENCES INTERNATIONAL

Add: 1818 Market St. Philadelphia, PA 19103

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Tel: (215) 299-8700 Fax: (215) 299-2273 E-mail: [email protected] Web site: www.dayzim.com President/CEO: Joseph T. Morrissey, Sr. R&D expertise: Architectural, design/ engineering research of biotech drugs, bioprocess engineering, cell and tissue culture, construction management, validation, CIM and start-up services. Major partners: Meissner+Wurst GmbH, Toyo Engineering Corp.

527

Principal products/instrumentation: Software package: Oligo, Genetool, Peptool, Gelimage software Cyrillic, Hyperchem, IDScan, Zero-Dscan, DNA Scan, IP Lab Gel, Gene Profiler, Gellab II, Model Maker, NCSS 2000; Operatin System: Linux, SGI-Irix, SunSolaris; Oligo-PCR/Primer design Software, GeneTool-DNA Sequence Analysis; PeptoolProtein Sequence Analysis; Gel image software, DNA Sequence Software, 1-D and 2-D Gel Analysis Quantitation, Gels Blots, STR, PCR, RFLP, RAPD, Cyrillic-Pedigree; Hypechem-Molecular Modeling; Molecular modeling software for drug design.

Joint ventures: Life Sciences, Meissner & Wurst, ToYo Engineering Co. (with LSI). Technological expertise: E, LP, RD, P/S, BA, C/TC, PMC, CH/S, SY, BS

1707

LIFESENSORS, INC.

Principal products/instrumentation: Biologicals, enzymes, single cell proteins, antibiotics, vaccines, specialty chemicals, monoclonal antibodies.

Add: 271 Great Valley Parkway Malvern, PA 19355

Subsidiary bodies: Life Sciences, Meissner & Wurst GmbH, Friolzheimer Strasse 5, D7Q499 Stuttgart, Germany, Tel: (49) 711-8804815; Life Sciences Int’l, Metro Office Park, Sprint Bldg., Suite 405, Street 1, Lot #18, Guaynabo, Puerto Rico 00968, Tel: (787) 781-8787.

Web site: www.lifesensors.com

1706

LIFE SCIENCE SOFTWARE RESOURCE, INC.

Add: 2160 Wayzata Blvd. West P.O. Box 335 Long Lake, MN 55356 Tel: (612) 871-7638 Fax: (612) 476-2999 E-mail: info@lifescience-software. com

Tel: (610) 644-8845 Fax: (610) 644-8616 President/CEO: Dr. Tauseef Butt Research director: Dr. Hiep Tran R&D expertise: Research of genomics, bioinformatics and high throughput drug screening of biotechnology medicines, related novel products manufacture. R&D collaboration: Rohm and Haas, Inc. National Institutes of Health, Embrex, Inc. Technological expertise: BI, DD, G, HTDS Main products/instrumentation under R&D: Material for producing gene libraries, high throughput drug screening. Sealed and Granted Patents: Methods and materials for producing gene libraries.

Web site: www.lifescience-software.com R&D expertise: Research of life science software for biotechnology medicines development. Technological expertise: CH/S, BTS, COC, D-D.

1708

LIFESPAN BIOSCIENCES

Add: 700 Blanchard St. Seattle, WA 98121 Tel: (206) 464-1554

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Fax: (206) 577-4565 E-mail: [email protected] Web site: www.lsbio.com President/CEO: Dr. Joseph Brown Research director: Glenna Burmer R&D expertise: R&D of target validation, gene discovery, proteomics; related novel products manufacture. R&D collaboration: Pfizer, Inc. Technological expertise: PA, Q, CH/S, GA, P/S, RD, R Principal products/instrumentation: Contract research/clinical trial products, human tissue bank with 1.5 million specimens; target validation services, either via ICC or ISH; gene discovery services; gene expression quantitation services. Main products/instrumentation under R&D: Protein expression and localization database. Sealed and granted patents: Protein expression and localization database, other patents pending.

1709

LIFE TECHMOLOGIES, INC.

Reagents; BioSepra® Process Chromatography; Specialty chemicals, enzymes, seras, serum-free media, balanced salt solutions, cell separation products, microbiological media and antibodies, growth factors, eukaryotic cells. Subsidiary bodies: Media analytical services, catalogue produce modification.

1710

LIGAND PHARMACEUTICALS, INC.

Add: 10275 Science Center Dr. San Diego, CA 92121 Tel: (609) 452-3600 Fax: (858) 550-7896 Web site: www.investors.ligand.com/releases. cfm President/CEO: David E. Robinson Research director: A. Negro-Vilar, M.D., Ph.D. R&D expertise: Discovery, development, manufacture and marketing of new biotechnology drugs through regulation of hormoneactivated intracellular receptors and signal transducers and activators of transcription.

Add: 5791 Van Allen Way Carlsbad, CA 92008

Joint ventures: Allergan, Therapeutics, Inc.

Tel: (760) 603-7200

R&D collaboration: Abbott, American Home Products, Glaxo, Pfizer, SmithKline Beecham, Allergan, E. Merck, Baylor College of Medicine, NIDDK, The Salk Institute for Biological Studies, Scripps Institute of Oceanography.

Fax: (760) 602-6500 E-mail: [email protected] Web site: www.lifetechnologies.com President/CEO: J. Stark Thompson, Ph.D. Research director: Derick Woods, Ph.D. R&D expertise: Development and manufacture of product for life science research and bioproduction; bioprocess engineering. Technological expertise: TE, BA, C/TC, GA, HTDS, RD, P/S Principal products/instrumentation: Gateway™ Cloning Technology, PCR Products and RT-PCR; Custom Primers; Nucleic Acid Purification Products; Cell Culture Media and

Key sales market contracts: Chiron for Proleukin®, QLT for Photofrin® — both in Canada. Technological expertise: THES, G Principal products/instrumentation: Photofrin® and Proleukin® (Canada only); Ontak, denileukin diftitox (fusion protein) for treatment of persistent or recurrent cutaneous T-cell lymphoma. Main products/instrumentation under R&D: Ontak (denileukin diftitox), for moderate to severe psoriasis, Phase II/III; severe rheumatoid

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arthritis (see also cancer, skin), Phase II; Targretin Oral, Phase II trials in patients with head and neck cancer, Kaposi’s sarcoma (KS), for advanced lung cancer, ovarian and prostate cancer, Phase II/III; Targretin Oral and Topical, in Phase III pivotal trials in cutaneous T-cell lymphoma (CTCL); Targretin Topical, in Phase II trials with actinic keratoses; Panretin Topical, in pivotal Phase III trials in KS; Panretin Oral, in Phase III pivotal trials in acute promyelocytic leukemia (APL) and Kaposi’s sarcoma; panretin oral in Phase II trials in myelodysplastic syndrome, ovarian and prostate cancer, and psoriasis. The National Cancer Institute (NCI) conducted Phase II trials with Panrerin Oral in breast cancer, bronchial metaplasia, KS and pediatric cancer; ALRT1550 in Phase I/II trials for cancer.

Fax: (973) 575-8494 Web site: www.ligochem.com President/CEO: David B. Golub Research director: Carmine C. Mascoli, Ph.D. R&D expertise: Bioseparations research and novel products manufacture. Technological expertise: P/S, BI, BA, LC/TC Principal products/instrumentation: HTLC™ — high throughput LC for large-scale protein purification; LigoSep™ A and FT — antibodies; Ligolink™ — DEAE and P; ProCipitate™ DNA and RNA isolation; Viraffinity™ viral capture; Cleanascite™ delipidrization; HemogloBind™ for gross hemolysis; bioseparation technology.

1713 1711

LIGHTOOLS RESEARCH

Add: 684 Poinsettia Park S. Encinitas, CA 92024 Tel: (760) 632-0677 Fax: (760) 632-0778 E-mail: [email protected]

529

LIMAGRAIN GENETICS, INC.

Add: P.O. Box 1088 Chatham, Ontario Canada Tel: (519) 265-5280 Fax: (519) 354-8155 E-mail: [email protected] Web site: www.prideseed.com President/CEO: Jim Simon

Web site: www.lightools.com

Research director: Antoon Van Der Reijden

President/CEO: John S. Fox

Subsidiary of Groupe Limagrain Holding.

Research director: John S. Fox

R&D expertise: R&D/manufacture of corn seed breeding, production and sale of seed, including hybrid corn, soybeans, canola.

R&D expertise: Development, design and manufacture of high performance imaging and detection systems. Technological expertise: CH/S, FL Principal products/instrumentation: Speedlight gel documentation system, speedlight platinum gel documentation system, ILLUMA TOOL tunable lighting system, Fluorescent lighting system.

Technological expertise: T, C/TC, CH/S Principal products/instrumentation: Pride brand seeds, including hybrid corn, soybeans, hybrid canola. Main products/instrumentation under R&D: Corn seed breeding.

1714 1712

LINC QUANTUM ANALYTICS

LIGOCHEM, INC.

Add: 9 Law Dr. Fairfield, NJ 07004

Add: 363 Vintage Park Drive Foster City, CA 94404

Tel: (973) 575-0082

Tel: (800) 992-4199

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Fax: (650) 312-0313

1716

LION BIOSCIENCE AG

E-mail: [email protected] President/CEO: Gerry Farren, Executive V. P.

Add: Im Neurenheimer Feld 515 69120 Heidelberg Germany

R&D expertise: Instruments of drug research.

Tel: (49) 6221-403-8011

Joint ventures: LINC Quantum, Apex Technologies, Apex Prosep Precolumn Separation Inlet.

Fax: (49) 6221-403-8101

Technological expertise: BME

President/CEO: Dr. Friednick Von Bohlen

Subsidiary bodies: LINC Capitol, inc. 303 E. Wacker Drive, Chicago, IL 60601.

Research director: Dr. Jan Mous, CSO

Web site: www.lqa.com

Principal products/instrumentation: Analytical and measuring instruments for drug R&Ds.

1715

LINK TECHNOLOGIES, LTD.

Add: 3 Mallard Way Strathclyde Business Park Bellshill, Lanarkshire MLY 3BF ML4 3 BF Scotland,U.K. Tel: (44) 1698-849-911 Fax: (44) 1698-849-922

E-mail: [email protected] Web site: www.lionbioscience.com

R&D expertise: Research of biotechnology integrated IT solutions for life science R&D, integrated drug discovery and diagnostics, related novel products development. R&D collaboration: Paradigm Genetics, Inc. and Tripos, Inc. Technological expertise: BI, CH/S, DD, G Principal products/instrumentation: bioSCOUT™, SRS, curray SCOUT™. Main products/instrumentation under R&D: Integrated proteins, integrated drug discovery route.

E-mail: [email protected] Web site: www.linktech.co.uk

1717

LIPHATECH, INC.

President/CEO: Dr. Mike Gray Research director: Dr. Douglas Picken R&D expertise: Development and manufacture of specialty chemical for biotechnology, reagents for DNA and RNA synthesis.

Add: 3600 West Elm Street. Milwaukee, WI 53209 Tel: (414) 351-1476 Fax: (414) 247-8166 E-mail: [email protected]

R&D collaboration: Glen Research Corp.

Web site: www.liphatech.com

Technological expertise: AB, SMC, SY

President: Thomas H. Winkofske

Principal products/instrumentation: SynBase: high loading support for solid phase DNA synthesis, reagents for synthesis of DNA/peptide conjugates.

Research director: R. Stewart Smith, Ph.D.

Main products/instrumentation under R&D: Biocatalytic technology, biocatalyst, reagents for DNA, RNA synthesizer, specialty chemicals for biotechnology.

Subsidiary of Lipha S.A. R&D expertise: R&D/manufacture of agriculture novel varieties. Technological expertise: F Principal products/instrumentation: Nitragin® legume inoculants; Soillmplant®; Cell-Tech®

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liquid inoculant; Rozol®, Maki®, BootHill®, Generation™ rodenticides, Hombre™. Main products/instrumentation under R&D: Biofungicides, agriculture novel varieties. Subsidiary bodies: Pilar, Argentina.

1718

LIPID PRODUCTS

531

Wyeth-Ayest International, Finland; WyethAyest International, Norway; Wyeth-Ayest International, Sweden; Wyeth-Ayest International, Iceland; Wyeth-Ayest International, Denmark; Wyeth-Ayest International, Austria; Wyeth-Ayest International, Greece; WyethAyest International, France; Wyeth-Ayest International, Italy. Technological expertise: C/TC, AF

Add: Nutfield Nurseries Crabhill Lane South Nutfield, Surrey RHI SPG U.K.

Principal products/instrumentation: ABELCET™, Lipoprotein, Lipotropin.

Tel: (44) 173-782-3277

Main products/instrumentation under R&D: EVACET™, liposomal doxorubicin , Phase III; TLC ELL-12, Liposomal Ether Lipid, preclinical.

Fax: (44) 173-782-2561 E-mail: [email protected] Research director: G A Jeffs Key sales market contracts: Life Science Resources Materials. R&D expertise: Development and manufacture of agriculture novel varieties and healthy food

Subsidiary bodies: The Liposome Manufacturing Co., INC. Indianapolis.

1720

LITMUS CONCEPTS, INC.

Technological expertise: P/S, SY

Add: 2981 Copper Rd. Santa Clara, CA 95051

Principal products/instrumentation: Lipids for biomedical research and food/agriculture research.

Tel: (408) 245-5525

Main products/instrumentation under R&D: Agriculture novel varieties, health food.

Research director: Paul Lawrence

1719

LIPOSOME CO., INC.

Add: One Research Way Princeton, NJ 08540 Tel: (609) 452-7060 Fax: (609) 452-1890 President/CEO: Charles A. Baker

Fax: (408) 245-1340 President/CEO: Paul J. Lawrence, Ph.D. R&D expertise: Development and manufacture of medical diagnostics and female healthcare products. Technological expertise: E, F Principal products/instrumentation: Female healthcare program, diagnostic drug. Main products/instrumentation under R&D: Female healthcare drugs, diagnostic enzymes, diagnostic test kits.

Research director: Andrew Janoff, Ph.D. R&D expertise: Development and manufacture of liposome and lipid-based pharmaceuticals and proprietary parenteral pharmaceuticals for life-threatening illnesses. Key sales market contracts: Laboratories Esteve, Spain; Laboratories Esteve, Portugal;

1721

LJL BIOSYSTEMS

Add: 404 Tasman Dr. Sunnyvale, CA 94089 Tel: (408) 541-8787 Fax: (408) 541-8786

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E-mail: [email protected] Web site: www.ljlbio.com President/CEO: Lev Leytes Research director: Drs. Doug Modlin and Jack Owicki R&D expertise: Development and manufacture of automated systems to improve the progress and productivity of drug discovery, automated systems and assays; products marketing. Key license and trade contracts: Telik, INC., FluorX

Principal products/instrumentation: Computer Autoradiography-Inquiry, Automated Micronucleus Assay, Automated Metaphase Finder, Automated Comet Assay, Automated Colony Counter, Mouse Lymphoma Assay, 3D Brain Station. Main products/instrumentation under R&D: Automated 160 slide stage, preclinical; Posiprobe MRI guided positron-brain measurement, preclinical; Dynamic model of the prostate for Urodynamic obstruction, preclinical; automated assays for drug preclinical research.

Technological expertise: HTDS Principal products/instrumentation: Analyst™, FITS Assay detection system; Advance™; FLARE™; automated systems of drug discovery. Sealed and granted patents: Methods and apparatus for detecting nucleic acid polymorphisms. 6,297,053, U.S.; cell-signaling assays, 6,806,053, U.S.

1723

LOCKWOOD GREENE

Add: P.O. Box 491 1500 International Dr. Spartanburg, SC 29304 Tel: (864) 578-2000 Fax: (864) 599-4117 E-mail: [email protected] Web site: www.lg.com

1722

LOATS ASSOCIATES, INC.

Add: 201 E. Main St. Westminster, MD 21157

President/CEO: Fred Brune Research director: Carl Bergsten

Tel: (410) 876-8055

Subsidiary of JA Jones, INC.

Fax: (410) 876-5843

R&D expertise: Bioprocess engineering and biotechnology medicines development/ manufacture.

E-mail: [email protected] Web site: www.loats.com President/CEO: Harry Loats Research director: Harry Loats R&D expertise: Development and products manufacture of automated assays for preclinical and gentoxicity. R&D collaboration: CRADA with Armed Forces Radiobiology Institute

Technological expertise: F, E, P/S, RD, LP, BA, C/TC Principal products/instrumentation: Biologicals, antibiotics, vaccines, specialty chemicals, enzymes, monoclonal antibodies. Main products/instrumentation under R&D: Bioprocess engineering technology, biotech medicines.

Key sales market contracts: Molecular Dynamics, Kormed Corp. (South Korea). Key license and trade contracts: Bioimage Technology, INC. Technological expertise: BI, CH/S, DD, D-D, HTDS

1724

LOCUS GENEX, OY.

Add: Laippatie 1 Helsinki 00880 Finland Tel: (358) 9-773-2900

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Fax: (358) 9-773-2867

Tel: (603) 610-4500

E-mail: [email protected]

Fax: (603) 610-5051

President/CEO: Erik Forsblom

E-mail: [email protected]

Research director: Niina Honkanen

Web site: www.lonza.com

R&D expertise: R&D/manufacture biotechnology, medicine products

of

Technological expertise: C/TC, RD, H/CF Principal products/instrumentation: Monoclonal antibodies to extracellular matrix components, neurotrophin integrins, cytoskeletal polypeptides, neurotrophic cytokine, neurotransmitter substances and endothelial cell surface markers.

1725

LOFSTRAND LABS, LTD.

Add: 7961 Cessna Ave. Gaithersburg, MD 20879 Tel: (800) 541-0362 Fax: (301) 948-9214 E-mail: [email protected] Web site: www.lofstrand.com President/CEO: Dr. Richard G. Smith Research director: Dr. Richard G. Smith R&D expertise: Contract development of recombinant molecular and cell biology, related novel products manufacture. Technological expertise: AB, C/TC, GA, H/CF, PB, P/S Principal products/instrumentation: Bactolift fermentor, Prehybe DNA recombinant protein. Main products/instrumentation under R&D: Recombinant molecular/cell biology reagents, recombinant proteins.

President/CEO: Ed Robinson Research director: Dr. John Birch Subsidiary of Alusuisse Lonza Holding (Public-Zurich). R&D expertise: Cell and tissue culture research, contract development of cell banking and cGMP manufacture of therapeutic proteins. Technological expertise: LP, E, PMC, BA, C/TC, GA, H/CF, P/S, RD Principal products/instrumentation: Biologicals, enzymes, monoclonal antibodies, vaccines, specialty chemicals. Main products/instrumentation under R&D: Producing numerous therapeutic proteins in Phase I through III clinicals and for commercial supply on behalf of client companies, mammalian gene expression systems, cell and tissue culture. Subsidiary bodies: FDA licensed cGMP manufacturing and development facilities in Slough, U.K.; cGMP manufacturing facilities in Portsmouth, NH. Sealed and granted patents: Intellectual property related to the glutamine synthetase mammalian gene expression system.

1727

LONZA BIOTECHNOLOGY (BIOTEC AND BIOLOGICS)

Add: Munchensteiner Str. 38 Basel CH 4002 Switzerland Tel: (41) 61-316-8111 Fax: (41) 61-316-9111

1726

LONZA BIOLOGICS, INC.

Add: 101 International Dr. Portsmouth, NH 03801

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E-mail: [email protected] Web site: www.lonza.com President/CEO: Dr. H. Rupp

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Research director: Dr. H-P Meyer; Dr. J.R. Birch R&D expertise: Development and manufacture of biologic and fine chemicals for the life science industry.

1729

LSK, A BRAIN TRAINING COMPANY

Add: Holt House 5 The Waits St. Ives, Cambridge PE17 4BY U.K.

Technological expertise: P/S, PMC, SY, F, Q, E, CC, RD, C/TC

Tel: (44) 772-046-8516

Principal products/instrumentation: Contract manufacturing products, L-Carnitine and derivatives; Cell culture media, 2007

Research director: Kari Kemp

Main products/instrumentation under R&D: Different intermediates and active ingredients, and therapeutic proteins.

Technological expertise: BI

Subsidiary bodies: Slough, U.K.; Portsmouth, NH, U.S.A.; Visp, Switzerland; Kourim, Czech Republic Sealed and granted patents: GS expression system.

President/CEO: Sonja Oren R&D expertise: Drug design, screening, development and manufacture. Principle products/Instrumentation: Contract research/clinical trial products; drug-resistance strain, drug screening, drug targeting, drug delivery platform.

1730

LSL BIOLAFITTE, INC.

Add: 719 Alexander Rd. Princeton NJ 08540 1728

LORUS THERAPEUTICS, INC.

Tel: (609) 452-7660 Fax: (609) 452-7667

Add: 7100 Woodbine Av. Ste.215 Markham, Ontario L3R 5J2 Canada

President/CEO: Dick Sadcowicz

Tel: (905) 305-1100

R&D expertise: Manufacture and supply of stirred tank fermentation equipment, stirred flow reactor, cell culture bioreactor systems and freeze dryers.

Fax: (905) 305-1584 E-mail: [email protected] Web site: www.lorusthera.com President/CEO: Dr. Jim A. Wright

Subsidiary of Cellex Biosciences, Inc.

Technological expertise: E, C/TC

Research director: Dr. Alping Young, V. P. in research

Principle products/instrumentation: Stirred tank systems (perfusion, or batch), stirred tank reactor.

R&D expertise: Research and development of oncology drugs; development and manufacture of anti-cancer products.

Main products/instrumentation under R&D: Stirred tank fermentation equipment, stirred flow reactor, cell culture bioreactor system.

R&D collaboration: AVI BioPharma, Inc

Subsidiary bodies: LSL Biolafitte SA, 10 Rue De Temara, 78100 St Germain-en-Laye, France.

Technological expertise: SMC, AB, GT, G Main products/instrumentation under R&D: GTI2040, GTI2501, NC 384, NC 381, preclinical; virulizin, Phase II/III; oncolysate, preclinical; anti-tumovigenic agents, laboratory research. Sealed and granted patents: All products.

1731

LTE SCIENTIFIC, LTD.

Add: Greenbridge Lane Greenfield Oldham, Lancashire 0L3 7EN U.K.

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Tel: (44) 1457-876-221

1733

535

LUCKY BIOTECH CORP.

Fax: (44) 1457-870-131 E-mail: [email protected] Web site: www.lte-scientific.co.uk President/CEO: Mr. Colin Perry R&D expertise: R&D/manufacture of laboratory, biomedical equipment and labwares for pharmaceutical research.

Add: 1000 Sylvan Avenue Englewood Cliffs, NJ 07632 Tel: (201) 816-2000 Fax: (201) 816-0961 President/CEO: Jae Kap Sung Research director: Joong Myung Cho, Ph.D.

Technological expertise: BME, HTDS, C/TC, Q

R&D expertise: R&D and manufacture of therapeutical drugs in biotechnology.

Principal products/instrumentation: Autoclaves, ovens, incubators, environmental rooms, freeze dryers.

Key license and trade contracts: UC Reagent.

Main products/instrumentation under R&D: Laboratory instruments/equipment and labwares for pharmaceutical research.

1732

LTF — LABORTECHNIK

Add: Schatter Str. 2 Wasserburg 88142 Germany Tel: (49) 83-8298-5203 Fax: (49) 83-8298-5232

Technological expertise: F, Q, RD, P/S, BA, H/CF, SY, C/TC Principal products/instrumentation: Human beta and gamma interferons, hepatitis B virus pre-S surface antigen, porcine and bovine growth hormone, hepatitis B virus diagnostic kit (surface antigen, core antigen, anti-surface antigen ELISA kit), hepatitis C diagnostics, Monellin. Main products/instrumentation under R&D: Human growth hormone, ANP, IGF, EGF, cytokine, pro sweeteners, lymphokines, hepatitis C vaccine, Neurotropin.

E-mail: [email protected] Web site: www.labortechnik.com Research director: Dr. Rudolf Walser

1734

LUMICYTE, INC.

R&D expertise: R&D/manufacture of laboratory professional instrumentation for drug isolation, analysis and identification.

Add: 4848 Lakeview Blvd. Fremont, CA 94538

Key sales market contracts: VL-Vilber Lourmat, Talent Sir., Corbett Research.

Fax: (510) 226-4901

Technological expertise: Q, C/TC, CH/S, GA, P/S

President/CEO: T. William Hutchens

Principal products/instrumentation: DNA Amplification in vitro; Thermo-Cyclers; Image Analysis System; Electrophoresis Equipment; DNA-Extraction Kits; Laboratory professional equipment.

Tel: (510) 226-3990 Web site: www.lumicyte.com Research director: Michael Hartley R&D expertise: Proteomics research and related novel products development. Technological expertise: BA, R, HTDS, SMC, CH/S, DD, D-D, P/PS, PC

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Principal products/instrumentation: BioPhore, BioChips, biocontrol.

Tel: (512) 219-8020

Main products/instrumentation under R&D: Molecular discovery, proteome, drug development service.

E-mail: [email protected]

Sealed and granted patents: SELDI Technology; Protein Analysis.

1735

LUMIGEN, INC.

Add: 22900 W 8 Mile Rd Southfield, Michigan, 48033 Tel: (248) 351-5600 Fax: (248) 351-0518 E-mail: [email protected] Web site: www.lumigen.com President/CEO: A. Paul Schaap, Ph.D. Research director: Hashem Akhavan-Tafti, Ph.D. R&D expertise: R&D/manufacture of chemiluminescent reagents for medical diagnostics, DNA profiling and life science research. Key sales market contracts: Amersham, Diagnostic Products Corporation, Digene, Life Technologies, Inc. Lifecodes, DuPont, Bayer, Beckman Coulter. Technological expertise: SY Principal products/instrumentation: Lumigen PPD; Lumi-Phos 480; Lumi-Phos 530; Lumi-Phos Plus; Lumi-Gal 530; Lumigen APS (these diagnostic products are registered trademarks of Lumigen, INC.). Main products/instrumentation under R&D: New ultra-sensitive chemiluminescent reagents for detection of alkaline phosphatase and horseradish peroxidase, coupling reagents.

1736

LUMINEX CORP.

Add: 12212 Technology Blvd. Austin, TX 78727-6115

Fax: (512) 219-5195 Web site: www.luminexcorp.com President/CEO: Dr. Mark Chandler Research director: Dr. Ralph McDade R&D expertise: Research, design, manufacture, and sales of mononucleotide polymorphic gene typing and microsphere-based solutions for measure multiple biomolecular interactions at the same time. Technological expertise: PA, Q, CH/S, HTDS, PB, P/S, R, RD Principal products/instrumentation: FlowMetrix™ System, LUMINEX 100, flow biomolecular meter. Flex MAP 3D™, a bead-based multiplexing system that bases xMAP® beadbased technology, 2007; microRNA detection (FlexmiR), a new line of microRNA products that can provide more than 6,300 data points in just four hours, 2007; mononucleotide polymorphic gene typing, immuno-diagnostic reagents of human diseases, gene screening products.

1737

LUNAIRE ENVIRONMENTAL

Add: 2121 Reach Road Williamsport, PA 17701 Tel: (570) 326-1770 Fax: (570) 326-7304 E-mail: [email protected] Web site: www.lunaire.com President/CEO: Michael Grausam Subsidiary of United Dominion Company. R&D expertise: Development and manufacture of stability test chambers. Technological expertise: BME Principal products/instrumentation: Stability test chambers, photostability chamber, environmental rooms.

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1738

LUXEMBOURG INDUSTRIES, LTD.

Add: P.O. Box 13 Tel Aviv 61000 Israel Tel: (972) 8-9466-040 Fax: (972) 8-5100-474 E-mail: [email protected] Web site: www.peptide-and-dna.com

537

5,863,722; 5,604,097; WO 96/41011; WO 95/27080 WO 97/46704; WO 99/35293; WO 98/53300(~2001); method of detecting the presence or absence of a plurality of target sequences using oligonucleotide. 6,280,935, U.S.; Solid phase selection of differentially expressed genes, 6,511,802, U.S.; DNA sequencing by parallel oligonucleotide extensions, 6,306,597, U.S. (2002 ~ 2008).

President/CEO: David Luxembourg R&D expertise: R&D/manufacture of related novel products for biotechnology medicines.

1740

LYOPHILIZATION TECHNOLOGY, INC.

Technological expertise: PIS, COC Principal products/instrumentation: Coupling Reagent for Solid Phase Peptide Synthesis.

Add: 30 Indian Dr. Ivyland, PA 18974 Tel: (215) 396-8373 Fax: (215) 396-8375 E-mail: [email protected]

1739

LYNX THERAPEUTICS, INC.

Add: 25861 Industrial Blvd. Hayward, CA 94545 Tel: (510) 670-9300 Fax: (510) 670-9302 E-mail: [email protected] Web site: www.lynxgen.com President/CEO: Norman Russell, Ph.D. Research director: Glenn Aibrecht, Ph.D. R&D expertise: R&D of genomics platform (differential gene analysis, expression profiling, fluid microarray), products manufacture. Joint ventures: BASF-Lynx.

Web site: www.lyotechnology.com President/CEO: Edward H. Trapper R&D expertise: Contract development and technical research of products for freeze drying. Technological expertise: AF, AB, BA, BS, CB, DD, D-D, PMC, P/S, SMC, PA, TE Principal products/instrumentation: Biomaterials, contract manufacturing products, contract research/clinical trial products, natural products, nutraceuticals, reagents, vaccines, veterinary products, freeze drier (lyophilizer).

1741

M & R DURANGO, INC.

R&D collaboration: Oxagen, Hybrigenics. Technological expertise: Q, BI, G

Add: 6565 Highway 172 Ignacio, CO 81137

Principal products/instrumentation: Registered MPSS, registered Magaclone.

Tel: (970) 259-3521

Main products/instrumentation under R&D: Genomic library, genomic sequencing, genomic platform, genes solid phase selection.

President/CEO: Lee Anne Merrill

Sealed and granted patents: 5,552,278; 5,559,675; 5,714,330; 5,831,011; 5,888,737; 5,635,400; 5,654,413; 5,695,934; 5,846,719;

Fax: (970) 259-3857 R&D expertise: Development and manufacture of beneficial bioinsects, beneficial nematodes and nosema locustae to control insect pests and grasshoppers for human healthcare and agriculture.

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Technological expertise: CS

Technological expertise: P/S, RD

Principal products/instrumentation: Green Lacewing, Nolo Bait, a biological control for grasshoppers; beneficial nematodes.

Principal products/instrumentation: MiniPrep 24, Flash Freeze and Enhanced Growth Media.

Main products/instrumentation under R&D: Beneficial bioinsects and beneficial nematodes to control insect pests.

Main products/instrumentation under R&D: Human genome mapping technology, clinical and research reagents, clinical and research laboratory instruments, microsealed drug delivery systems.

1742

MAB TECHNOLOGIES, INC.

Add: 392 Nalley Dr. Stone Mountain, GA 30087

1744

Tel: (704)548-9185 E-mail: [email protected] Web site: www.mabtechnologies.com President/CEO: Craig Heilman R&D expertise: Research of hybridoma/cell fusion, related therapeutical products development and manufacture.

MACHEREY-NAGEL GMBH & CO. KG

Add: P.O. Box 10 13 52 Dueren D-52313 Germany Tel: (49) 2421-969-899 Fax: (49) 2421-969-199 E-mail: [email protected]

Technological expertise: H/CF

Web site: www.macherey-nagel.com

Principal products/instrumentation: Serotonin transporter mAb, Noreprinephrine transporter mAb.

President/CEO: Dr. E. Radmacher

Main products/instrumentation under R&D: Hybridoma/cell fusion, anti-carcinogenic mAb.

1743

MaCCONNELL RESEARCH

Research director: Dr. M. Sieber R&D expertise: Research of molecular biology; therapeutical products development/manufacture. R&D collaboration: Clontech Laboratories, Inc. Technological expertise: CC, P/S, HTDS, GT

Add: 9550 Waples Street. San Diego, CA 92121

Principal products/instrumentation: Nucleo Bond AX, Nucleo-Trap, NucleoSpin.

Tel: (858) 466-7949

Main products/instrumentation under R&D: High throughput isolation tests for molecular biology and clinical diagnostics, molecular biology reagents.

Fax: (858) 452-6753 E-mail: [email protected] Web site: www.macconnell.com President/CEO: William P. MacConnell, Ph.D. Research director: William P. MacConnell, Ph.D. R&D expertise: Development and manufacture of clinical and research laboratory instrumentation and reagents.

1745

MACROCHEM CORP.

Add: 40 Washington Street Suite 220 Wellesley Hills, MA 02481 Tel: (781) 489-7310

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1747

Web site: www.macrochem.com

539

MAGNETIC DELIVERED THERAPEUTICS, INC.

President/CEO: Alvin J. Karloff Research director: Dr. Carlos M. Samour R&D expertise: Drug delivery research, related novel products manufacture. R&D collaboration: Dermik Laboratories, Knoll Pharmaceuticals.

Add: 18200 W. Highway 72 Arvada, CO 80007-8237 Tel: (303) 432-8630 Fax: (303) 432-9446 E-mail: [email protected]

Technological expertise: D-D, DD, COC

President/CEO: Thomas Kent

Principal products/instrumentation: SEPA™.

R&D expertise: Development and production of biopharmaceutical drug delivery via magnetically guided systems

Main products/instrumentation under R&D: SEPA-Acyclovir, SEPA-Papaverine, SEPAEconazole, SEPA-Spiranolactone, drug delivery platform, drug delivery system. Subsidiary bodies: University of Paris, University at Mian.

1746

MAGAININ PHARMACEUTICALS, INC.

Technological expertise: AB, DD, GT Main products/instrumentation under R&D: Magnetically guided carboferro nanoparticles for genetic, immune and chemotherapies, screening for targeted delivery of drugs.

1748

MAINE BIOTECHNOLOGY SERVICES, INC.

Add: 5110 Campus Dr. Plymouth Meeting, PA 19462

Add: 1037R Forest Ave. Portland, ME 041033304

Tel: (610) 941-4020

Tel: (207) 797-5455

Fax: (610) 941-5399

Fax: (207) 797-5595

E-mail: [email protected]

E-mail: [email protected]

President/CEO: Jay Moorin

Web site: www.mainebiotechnology.com

Research director: Dr. Roy Levitt

President/CEO: Joseph P. Chandler, Ph.D.

R&D expertise: R&D/manufacture of antiinfectives and anti-cancer products based upon compounds isolated from the host defense system of animals.

Research director: Joseph P. Chandler, Ph.D.

R&D collaboration: Sandoz, Colgate Palmolive. Technological expertise: F, SY, DD, RD, P/S, BA, GA, CH/S Main products/instrumentation under R&D: Anti-infective agent, anti-cancer agent (anticancer drug, anti-carcinogen), anti-carcinogenic compounds isolated from the host defense system of animals.

R&D expertise: Monoclonal and polyclonal antibodies contract development/production; antibody purification, in vitro antibody production, cryopreservation (MCB+WC8); antibody conjugation, immunoassay development, hybridoma development. Key sales market contracts: Biodesign International — antibody + service distribution. Key license and trade contracts: Bioclin, Inc. — monoclonal antibody; University of Connecticut — monoclonal antibody.

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Technological expertise: P, B, H, C/TC, P/S, BA, H/CF Principal products/instrumentation: Endothelin receptor polyclonal antibodies, bromodeoxyuridine polyclonal antibody, hCG monoclonal antibodies.

1749

MAJOR SCIENCE

Add: No. 7, Hwai-Der Str. Pan-chiao City, Taipei Hsien 220 Taiwan Tel: (886) 2-2256-6980 Fax: (886) 2-2256-6942 E-mail: [email protected] Web site: www.major-sci.com President/CEO: Rock Chuu Research director: Alpha Wang R&D expertise: R&D of biotechnology field, novel products manufacture. Technological expertise: F, Q, T, GA, BME, SI Principal products/instrumentation: Mini electrophoresis apparatus, electrophoresisgrade reagents, MIDI 250 voltages power supply, Max Power programmable power supply. Main products/instrumentation under R&D: Thermocycler; shaker; automatic blotting system; thermal chromatography.

cancer; development of second-generation vaccines against infectious diseases; related novel products manufacture. Technological expertise: P/S, BA, H/CF, PMC, CB, C/TC Principal products/instrumentation: Makari Intradermal Test (MIT) for detection of early cancer and early cancer recurrence. Main products/instrumentation under R&D: MIT for the U.S. market, cancer immune surveillance test, immunoprevention and immunotherapy of cancer; monoclonals specific for lung and colon cancer, C-5F-10 monoclonals specific for mitotic cells; second generation of vaccines against flu, gram-negative infections. Sealed and granted patents: 4 U.S. patents in cancer and treatment; others pending.

1751

MALAYSIAN BIO-DIAGNOSTICS RESEARCH SDN BHD

Add: Block Intron-Ekson, UKM-MTDC Smart Technology Centre 43650 Bangi, Selangor Malaysia Tel: (60) 3-826-1205/06/07 Fax: (60) 3-826-1810 E-mail: [email protected] Web site: www.mbdr.net President/CEO: Ambok Chening Meri

MAKARI RESEARCH LABORATORIES, INC.

Research director: Tuan Afifah Than Ibrahim

Add: 223 S. Dean St. Englewood, NJ 07631 Tel: (201) 871-3244

R&D expertise: Development and manufacture of biodiagnostics assays.

Fax: (201) 871-3363

Technological expertise: PA, RD, PIS

President: Jack George Makari, M.D.

Principal products/instrumentation: Typhidot

Research director: Jack George Makari, M.D.

Main products/instrumentation under R&D: Paratyphoid A, R&D; Champylobacter Jejuni, R&D against malaria, tropical diseases.

1750

R&D expertise: Cancer immunology research in relation to early diagnosis and treatment of

Subsidiary of Malaysian Technology Development Corporation (MTDC).

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MALLINCKRODT BAKER, INC.

Add: 222 Red School Lane Phillipsburg, NJ 08865

541

Sealed and granted patents: Tumor-targeted optical contrast agents, 6,641,798, U.S.; Receptor-avid exogenous optical contrast and therapeutic agents, 6,706,254, U.S.

Tel: (908) 859-2151 Fax: (908) 859-9454 President/CEO: Dan Mulholland Research director: John B. Covington, Ph.D. R&D expertise: Development and manufacture of specialty biochemicals and related biochemical products for research and production applications.

1754

MALVERN INSTRUMENTS, INC.

Add: Enigma Business Park,Grovewood Road Malvern, Worcestershire WR14 1XZ, U.K. Tel: (44) 1684-892-456 Fax: (44) 1684-892-456 E-mail: [email protected]

Technological expertise: Q, BA, P/S, AB, SY

Web site: www.malvern.com

Principal products/instrumentation: USP Process Salts, Ultrapure Bioreagents, Global Pharma products, Amino Acids, High Purity Solvents, BAKERBOND Chromatography Media, LC/MS solvents, 2007.

President/CEO: Brian Dutko

Main products/instrumentation under R&D: New bioreagents, USP chemicals, electrophoresis media, chromatography media and CYCLE-TAINER® solvent dispense systems.

1753

MALLINCKRODT, INC.

Add: 16305 Swingley Ridge Dr. Chesterfield, MO 63017 Tel: (314) 530-2172 Fax: (314) 530-2563

Subsidiary of Malvern Instruments, Ltd. R&D expertise: Development and manufacture of laboratory biomedical equipment. Technological expertise: CH/S, BME, SI, FL Principal products/instrumentation: Mastersizer, Micro-Zetamaster, Zetasizer, EPCS, Spraytec, Ultrasizer. Main products/instrumentation under R&D: Laboratory scale purification devices, labwares, biotechwares.

1755

MANDEL SCIENTIFIC COMPANY, LTD.

President/CEO: Mike Collins

Add: 2 Admiral Place Guelph, Ontario NIG 4N4 Canada

Research director: Ervin Inskip

Tel: (519) 763- 9292

R&D expertise: Development and manufacture of biopharmaceutical, chemicals, fine chemicals, specialty chemicals, catalysts etc.

Fax: (519) 763-2005

Technological expertise: P/S, SY, DD, CS, PIS

Web site: www.mandel.ca

Principal products/instrumentation: Narcotics, analgesics, large scale custom synthesis of peptides.

R&D expertise: Development/manufacture/ supply of laboratory equipment, specializing in analytical equipment and liquid handling.

Main products/instrumentation under R&D: Proprietary peptides, fine chemicals, specialty chemicals, catalytic antibodies.

Technological expertise: BME, SI, FL

E-mail: [email protected]

Principal products/instrumentation: Chromatography products, Microsol, TLC plates

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and TLC apparatus, nitrogen and suffer analyzers, incubators, hybridization apparatus, Agarose and Polyacrylamide gels, 8 and 12 channel pipettes, molecular biology kits, manual liquid handling and chromatology equipment, FTIR accessories, dissolution test systems, liquid handling and media processing, Powerpette, Sorvall centrifuges and Heraeus centrifuges, ovens, specialty glass, Microscope Documentation Systems (MDS 209), EDAS Gel Documentation System (EDAS 290), Image Station 440cf, micrography film and cassettes, microcentrifuges, light boxes, hybridization ovens, FTIR, TOX analyzers, moisture meters, Ultrasonic Cleaners, Ultrasonic Sonicators, fume hoods, radioactive compounds, microarrays, Automated Titration System, FTIR accessories, tips, membranes, bench paper, blotting paper, syringes, chromatography accessories, UV and fluorescent quartz cells, gas chromatography, spectrophotometers, fluorescence spectrophotometers, TOC’s, Thermal Analyzers, balances, tubes, racks, columns (wide pore), filter paper, laboratory and field meters.

Technological expertise: F, BA, C/TC, DD, D-D Principal products/instrumentation: ESSIAC trademark for cancer treatment product, Radon Guard trademark products for Radon control, Imuregen trademark for cancer therapy. Main products/instrumentation under R&D: AIDS and cancer treatment drugs; compounds treatment for MS, ALS, AIDS, and neuro-muscular diseases; AIDS vaccines; pesticides to control and decimate cannabis and coca plants.

1757

MANOSTAT PUMPS (DIVISION OF BARNANT CO.)

Add: 28 W. 092 Commercial Ave. Barrington, IL 60010 Tel: (847) 381-7050 Fax: (954) 977-0744 E-mail: [email protected] Web site: www.barnant.com President/CEO: George Sezemsky Subsidiary of Barnant Co.

1756

MANKIND RESEARCH FOUNDATION, INC.

Add: 1315 Apple Ave. Silver Spring, MD 20910 Tel: (301) 587-8686 Fax: (301) 587-8959

R&D expertise: Manufacturing and marketing of peristaltic pumps and systems. Technological expertise: BME Principal products/instrumentation: Manostat pumps and pump systems. Main products/instrumentation under R&D: Micropumps, peristaltic pumps, pump spray systems.

E-mail: [email protected] President/CEO: Carl Schleicher, Ph.D.

1758

MAPLEHURST GENETICS INTERNATIONAL, INC.

R&D expertise: Biotechnology R&D with focus on natural drug products for treatment of cancer, AIDS, MS, ALS, AIDS, and other degenerative illnesses, related novel drugs manufacture.

Add: 32323 190th St. Keota, IA 52248-9432

Joint ventures: ESSIAC Products.

Web site: www.maplehurstgenetics.com

R&D collaboration: Jason Pharmaceuticals.

President/CEO: R. A. Carmichael, D.V.M.

Tel: (641) 636-3811 Fax: (641) 636-3838

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Research director: Cindy Gretter

Fax: (415) 883-8011

R&D expertise: Drug delivery research, new products development; international marketing of E.T. (embryo transfer) and A.I. (artificial insemination) and veterinary products.

E-mail: [email protected]

Key sales market contracts: International distributors. Technological expertise: DD Principal products/instrumentation: Veterinary products, specialty chemicals, vaccines, pharmaceuticals, detergents, diagnostics, reagents. Sealed and granted patents: Microscope, manipulator.

1759

MARCOR DEVELOPMENT CORP.

Add: 341 Michele Place Carlstadt, NJ 07072 Tel: (201) 935-2111 Fax: (201) 935-5223

543

Web site: www.marinbio.com President/CEO: Tania L Weiss, Ph.D. Research director: Molly Dobkoski R&D expertise: Contract research, development and manufacturing of drugs products in cell biology, molecular biology, biochemistry, immunology (including monoclonals), in vitro toxicology, and assay development (GLP/ GMP), biotechnology, pharmaceutical, diagnostic and agriculture industries. Technological expertise: AB, BA, BS, E, F, CB, C/TC, DD, D-D, P/S, SMC, PA, TE, GA, FT, G, HTDS, H/CF, PB, RD Principal products/instrumentation: Contract R&D products, therapeutics, diagnostics. Main products/instrumentation under R&D: Cell and molecular biology reagents, monoclonal antibodies, diagnostic antibodies, diagnostic kits.

E-mail: [email protected] President/CEO: Charles J. Garbarim Research director: Dr. William Lahl & Dr. Michael Malavasic

1761

MARINE GENE PROBE LABORATORY

R&D expertise: Development and bulk supplier of fermentation nutrients and fine chemicals.

Add: Biology Dept, L.S.C. Dalhousie University Halifax, NS B3H 4J1 Canada

Key sales market contracts: Universal Foods Corporation.

Fax: (902) 494-6899

Technological expertise: F, E, ET, ERT Principal products/instrumentation: Fermentation nutrient drug, nutraceuticals. Main products/instrumentation under R&D: Fine chemicals, fermented dairy food.

Tel: (902) 494-1398 E-mail: [email protected] Web site: http://is.dal.ca/~mgpl/mgplhome.htm President/CEO: Drs J. M. Wright/C. Taggart Research director: Drs. J. M. Wright/C. Taggart

Add: 3152 Paradise Dr. Tiburon, CA 94920

R&D expertise: Research, development and application of sustainable fishery management tools using genetic technology and aquaculture broodstock management system using DNA typing technology, molecular genetics techniques for academics and professionals.

Tel: (415) 883-8000

R&D collaboration: Area universities.

1760

MARIN BIOLOGIC LABORATORIES, INC.

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Technological expertise: Q, CH/S, RD, BME Main products/instrumentation under R&D: Genetic-based information tools (microsatellite markers and population databases) for the following species for fisheries and aquaculture stock analyses: salmonid, tilapia, sea scallop, carp, shrimp, winter flounder, silver barb, herring, sea bream and cod. Salmonid species include: rainbow trout, brown trout, brook trout, Atlantic salmon, Pacific salmon, Arctic char, etc.

R&D expertise: Development and manufacture of drug design tools, diagnostics, biopharmaceuticals and nutritional supplements. Principle products/instrumentation: Contract R&D products, drug design tools. Sealed and granted patents: Polyunsaturated fatty acid production in heterologous organisms using PUFA polypeptide synthase systems, 20070245431, U.S.

1764 1762

MARKER GENE TECHNOLOGIES, INC

MARVEL SCIENTIFIC

Add: P.O. Box 400 Greenville, MI 48838-0400 Tel: (616) 754-5601 Fax: (616) 754-0970

Add: I850 Millrace Dr. Eugene, OR 974031927 Tel: (541) 342-3760 Fax: (541) 342-1960

E-mail: [email protected] Web site: www.marvelindustries.com President/CEO: Gordon Stauffer

R&D expertise: Gene Therapy research.

R&D expertise: Development and manufacture of biomedical laboratory refrigerators, freezers, refrigerators/freezers for general purpose, flammable material storage and hazardous location.

Joint ventures: OHSU, Intergen, Teflabs.

Technological expertise: BME

R&D collaboration: Cytovia, INC.

Principal products/instrumentation: Refrigerators, freezers, refrigerator/freezers.

E-mail: [email protected] Web site: www.markergene.com President/CEO: Dr. John Naleway

Technological expertise: E, CB, C/TC, D-D, DD, GT, HTDS, H/CF, PG Main products/instrumentation under R&D: Anti-tumor gene therapy, preclinical; anti-cancer gene therapy, R&D. Sealed and granted patents: Gene Therapy, pending.

1765

MASOUD ESTABLISHMENT OF MEDICAL AND SCIENTIFIC SUPPLY

Add: P.O. Box 6351 Amman 11118 11118 Jordan Tel: (962) 6460-3666 Fax: (962) 6462-4959

1763

MARTEK BIOSCIENCES CORP.

Add: 6480 Dobbin Rd. Columbia, MD 21045 Tel: (410) 740-0081 Web site: www.martekbio.com President/CEO: Henry Linsert Jr.

President/CEO: Bilal Masoud R&D expertise: Manufacture and supply of biomedical, scientific laboratory supplies and biochemicals in Jordan. Technological expertise: AB, BME, PA, MAE, E

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Principal products/instrumentation: Biomedical, scientific laboratory, research biomedical products.

1766

MASSTRACE, INC.

Add: 3-G Gill St. Woburn, MA 01801 Tel: (781) 932-6770

545

Principal products/instrumentation: CLA allergy test, MASTpette® test chamber. Main products/instrumentation under R&D: Infectious disease test. Subsidiary bodies: Grass Valley, CA.

1768

MATERIA MEDICA, INC.

Fax: (781) 932-6775

Add: P.O. Box 4040 Jenkintown, PA 19046

E-mail: [email protected]

Tel: (215) 885-4205

Web site: www.masstrace.com

Fax: (215) 885-4205

President/CEO: Peter B. Leone

President/CEO: David Halpern, Ph.D.

Research director: Alfred Ajami, Ph.D.

Research director: B.D. Halpem

R&D expertise: Biomarkers development/ manufacture for in vivo/in vitro measurement products of enzyme activity.

Marketing: R. Weaver

Technological expertise: ET, ERT, CC, E, CB, D-D, PG, SMC, SY

Major partners: Alchem International Ltd.

Principal products/instrumentation: Research biochemicals, Diagnostic Reagents, Meta Probe, Biomarkers. Main products/instrumentation under R&D: In vivo/in vitro measuring instruments of enzyme activity.

1767

MAST IMMUNOSYSTEMS, INC.

Add: 630 Clyde Ct. Mountain View, CA 94043 Tel: (415) 961-5501 Fax: (415) 969-2745 Web site: www.immunos.com President/CEO: Tetsvo Odashiro Research director: Chris Brown Subsidiary of Hitachi Chemical Company. R&D expertise: Development and manufacture of in vitro diagnostics. R&D collaboration: Hitachi Chemical. Technological expertise: MAE, PA, R, AB

R&D expertise: Bioprocess engineering research/manufacture. Technological expertise: LP, DD, P/S, SY Principal products/instrumentation: Slkaloids, natural products, bioremediation, biomaterials.

1769

MATHSOFT, INC.

Add: 1700 Westlake Ave.N. Ste. 500 Seattle, WA 98109 Tel: (206) 283-8802 Fax: (206) 283-8691 Web site: www.splus.mathsoft.com President/CEO: Charles Digate Research director: George Mellman R&D expertise: Bioinformatics software development and manufacture Technological expertise: BI, CH/S Principal products/instrumentation: S-PLUS 2000; StatServer 2000; contract manufacturing products, contract research/clinical trial products.

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Main products/instrumentation under R&D: S+Seq Trial.

1770

MATREYA, INC.

Add: 168 Tressler St. Pleasant Gap, PA 16823 Tel: (814) 359-5060 Fax: (814) 359-5062 Web site: www.matreya.com E-mail: [email protected] President/CEO: Michael C. Seidel, Ph.D. Research director: Michael C. Seidel, Ph.D. R&D expertise: Development and manufacture of lipids, specialty biochemicals, some antibodies custom synthesis. Key sales market contracts: Genzyme Corp. Key license and trade contracts: Emory University. Technological expertise: CC, P/S, SMC, SY Principal products/instrumentation: Contract R&D products, lipid granule, lipid micelle, natural antibodies, sessile antibodies, complete antibodies, monoclonal antibodies, polyclonal antibodies, specialty biochemical.

for 7 cancer types); Sangtec (seum assay for breast cancer); Boehringer Ingelheim International, GmbH. Key sales market contracts: Hybritech; Yamanouchi; Sangtec. Key license and trade contracts: Massachusetts Institute of Technology; Johns Hopkins University. Technological expertise: Q, AB, RD, P/S, H/CF, C/TC, CH/S Principal products/instrumentation: NMP22® test kit for bladder cancer for patients in vitro diagnostic use; Nuclearmatrix protein ELISA (enzyme-linked immunosorbent assay) kits and monoclonal antibodies for research use. Main products/instrumentation under R&D: Urine assay for bladder cancer; serum assays for breast, colon, lung and prostate cancers; antibody-based product to augment cervical Pap smear; cell-based product for prostate cancer.

1772

MATRIX SCIENCE, LTD.

Add: 64 Baker Street London W1U 7GB U.K. Tel: (44) 20-7486-1050 Fax: (44) 20-7224-1344

1771

MATRITECH, INC.

E-mail: [email protected] Web site: www.matrixscience.com

Add: 330 Nevada St. Newton, MA 024601458

R&D expertise: Development and manufacture of bioinformatics software.

Tel: (617) 928-0820

Technological expertise: BI, CH/S

Fax: (617) 928-0821

Principal products/instrumentation: Mascot protein identification package; bioinformatics software of protein identification.

Web site: www.matritech.com President/CEO: David L. Corbet Research director: Ying-Jye Wu, Ph.D. R&D expertise: Development and manufacture of proprietary matrix protein (NMP) technology to develop cancer diagnostic products. R&D collaboration: Hybritech (urine assay for bladder cancer); Yamanouchi (serum assays

1773

THERMO FISHER SCIENTIFIC INC.

Add: 22 Friars Drive. Hudson, NH 03051 Tel: (603) 595-0505

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Fax: (603) 595-0106

Research director: Magnus Pfahl, Ph.D.

Web site: www.matrixtechcorp.com

R&D expertise: Discovery, development, manufacture and commercialization of novel small molecule therapeutics for function by specific signal transduction mechanisms in targeted therapeutic areas.

President/CEO: Gary Nelson Research director: Greg Mathaus R&D expertise: Development and manufacture of liquid handling machinery. Technological expertise: R, HTDS, BME Principal products/instrumentation: Electronic pipettors, Electra pette, high throughput screening products, track mates, plate mate, liquid handling instruments.

1774

MATTEK CORP.

Add: 200 Homer Ave. Ashland, MA 01721 Tel: (508) 881-6771 Fax: (508) 879-1532

R&D collaboration: Galderma. Technological expertise: SMC, CS, PPAT Main products/instrumentation under R&D: MX6 for treatment of cervical intraepithelial neoplasia, Phase III; MXC3255 for treatment of type 2 diabetes, Phase I; leads for treatment of solid tumors, arthritis, asthma, inflammatory bowel disease and cardiovascular disease, novel small molecule therapeutics. Subsidiary bodies: Office in the U.K. for clinical and regulatory matters in Europe. Sealed and granted patents: Rights to numerous patents.

E-mail: [email protected] Web site: www.mattek.com President/CEO: John E. Sheasgreen

1776

MAXIM BIOTECH, INC.

Research director: Mitch Klausner (V.P. Scientific Affairs)

Add: 1500 E. Gude Drive, Rockville, MD 20850

R&D expertise: Development/manufacture of in vitro toxicology test products.

Tel: (301) 217-0637

Technological expertise: TE, C/TC, DD, AF

E-mail: [email protected]

Principal products/instrumentation: EpiDenrm™ skin model; EpiOcular; MelanoDerm.

Web site: www.maximbio.com

Main products/instrumentation under R&D: In vitro toxicology test kits.

1775

MAXIA PHARMACEUTICALS, INC.

Add: 10835 Altman Row Suite 250 San Diego, CA 92121 Tel: (858) 824-1988 Fax: (858) 824-1967 President/CEO: Magnus Pfahl, Ph.D.

Fax: (301) 217-9080

President/CIO: Mei-Jhy Su CEO: Joe Maa Research director: Rob Chou R&D expertise: Development and manufacture of DNA-based diagnostics reagents; drug screening gene expression. Key license and trade contracts: SUNY at Stony Brook — Yeast two-Hybrid. Technological expertise: C/TC, GA, H/CF, RD, HTDS, PA, P/S, SY Principal products/instrumentation: MPCR optometer kit; MPCR application kits; DNA/ RNA isolation kits; In situ hybridization/detection

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kit; Southern Hybridization/detection kit; page display, cDNA library; yeast two hybrid, cDNA library. Main products/instrumentation under R&D: Genetic fingerprint, genetic spontaneous mutation screening and telomere length screening; DNA-based diagnostic reagents. Subsidiary bodies: Fuzhou Maxim Biotech, INC. (China, Fuzhou).

1777

MAXIM PHARMACEUTICALS

a hydrogen peroxide scavenger or inhibitor, 6,375,946, U.S.; methods and compositions for promoting the maturation of monocytes, 6,790,440, U.S.

1778

MAXXAM ANALYTICS, INC.

Add: 6740 Campobello Rd., Mississauga, ON L5N 2L8 Tel: (905) 817-5700 Fax: (905) 817-5777

Add: 8899 University Center Lane Ste. 400 San Diego, CA 92122

E-mail: [email protected]

Tel: (858) 453-4040

President/CEO: John Stanley

Fax: (858) 453-5005

Research director: John Fenwick

E-mail: [email protected]

R&D expertise: Contract research organization of biotechnology medicines; contract analytical research services; DNA testing laboratory, LC/MS and LC/MS/MS research services.

Web site: www.maxim.com President/CEO: Larry Stambaugh Research director: Kurt Gehlsen, Ph.D. R&D expertise: Development and manufacture of novel professional therapeutics and vaccines for the prevention and treatment of cancer and infectious disease. R&D collaboration: Two R&D contracts/grants with the University of Gothenburg, Sweden. Key license and trade contracts: Several with inventors of technology, one with Vitec, AB, and one with SBL Vaccin AB. Technological expertise: F, PA, Q, C/TC, SY, TE, COC, DD, D-D, GA, GT, H/CF, PB, P/S, RD, SMC Principal products/instrumentation: Lead product. Main products/instrumentation under R&D: Maxamine in three Phase III trials, Maxamine in three Phase II trials, Maxamine in one Phase I trials, MaxVax in preclinical. Sealed and granted patents: 7 issued, 11 pending (~ 2001); enhanced activation of natural killer cells using an NK cell activator and

Web site: www.maxxam.ca

Joint ventures: Maxxam BioDiscoveries, INC. (Allelix, INC.). Technological expertise: Q, SMC, HTD, PG, R Principal products/instrumentation: Rapid, automated drug bioanalytical services, Auto Assay, DNA testing. Subsidiary bodies: Calgary, AB — Tel: (800) 386-7247, Fax: (403) 291-9468; Edmonton, AB — Tel: (800) 386-7247, Fax: (466) 3332; Grande Prairie, AB — Tel: (403) 532-0227, Fax: (403) 532-0288; Stealer, AB — Tel: (403) 742-1107, Fax: (403) 742-0170; Fort McMurray, AB — Tel: (800) 386-7247; Guelph. ON — Tel: (519) 836-2400, Fax: (519) 836-5782; Niagara, ON — Tel: (905) 687-8378, Fax: (905) 687-8487; Etobicoke, ON — Tel: (416) 235 5962, Fax: (416) 235-6024; Montreal, QC — Tel: (514) 636-6218, Fax: (514) 6319814. Laboratories in: Mexico City, Mexico; Bratislava, Slovakia; Bangkok, Thailand.

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1779

MAXYGEN, INC.

549

E-mail: [email protected] Web site: www.szmaysun.com/index.htm

Add: 301 Galveston Drive Redwood City, CA 94063 Tel: (650) 298-5300 Fax: (650) 364-2715 E-mail: [email protected] Web site: www.maxygen.com President/CEO: Dr. Russell Howard Research director: Dr. Willem Stemmer R&D expertise: Application research and products manufacture of molecular cloning evolution technologies (DNA shuffling) to human and animal therapeutics, including vaccines, gene therapy, protein. R&D collaboration: Two undisclosed corporate partnerships, several academic collaborations. Key license and trade contracts: Novo Nordisk. Technological expertise: E, RD, D-D, HTDS, GT Principal products/instrumentation: DNA kits, vaccines, contract R&D products, DNA shuffling, gene therapy, molecular evolution technology. Sealed and granted patents: U.S. patents No. 5,605,793 — “Methods for in vitro recombination”; Targeting of genetic vaccine vectors, 20080019988, U.S.; Optimization of crossover points for directed evaluation, 20080020397, U.S.

1780

MAYSUN BIOMEDICA, INC.

Add: 4B, Huayi Building, Xiangyi Mingyuan, Xiangmei Road, Shenzhen, Guangdong, China. Tel: (86) 755-8294-6108 Fax: (86) 755-8294-6208

President/CEO: Meicheng Lu R&D expertise: Manufacture and marketing of biomedical products and diagnostic reagents. Joint ventures: Shanghai Hygenc Biotech, INC.; Shanghai Bioresun Institute, INC. Technological expertise: E, F, PA, RD, Q, SMC, BA, C/TC, DD, D-D, GA, GT, HTDS, H/CF, P/S Principal products/instrumentation: In vitro toxicology testing method, pharmaceuticals, reagents, vaccines, biomaterials. Main products/instrumentation under R&D: Laboratory biomedical instruments for pharmaceutical research, diagnostic reagents, diagnostic test kits.

1781

MAYSUN ENTERPRISES, INC.

Add: 2213 S. Baeswood Blvd., Ste. 1-3H Houston, TX 77030-4321 Tel: (713) 795-0786 Fax: (713) 795-0741 E-mail: [email protected] President/CEO: Meisheng Lu R&D expertise: Biomedical products and diagnostic reagents development/manufacture. Joint ventures: Shanghai Hygene Biotech, INC.; Shanghai Bioresun Institute, INC. Technological expertise: E, F, PA, RD, Q, SMC, BA, C/TC, DD, D-D, GA, GT, HTDS, H/CF, P/S Principal products/instrumentation: Biologicals, biomaterials, diagnostics, in vitro toxicology testing method, pharmaceuticals, reagents, vaccines. Main products/instrumentation under R&D: Laboratory biomedical instruments for pharmaceutical research, diagnostic reagents, diagnostic test kits.

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MBI INTERNATIONAL

Add: 3900 Collins Rd. Lansing, MI 489108596 Tel: (517) 337-3181 Fax: (517) 337-2122 E-mail: [email protected] Web site: www.mbi.org President/CEO: John Welser Research director: Doug Rivers, Ph.D. R&D expertise: Biotechnology medicines development, bioprocess engineering research. Technological expertise: LP, BA, CB, CC, GA, P/S, H/CF

Technological expertise: P, BP, P/S, LP, ERT, PC Principal products/instrumentation: 3M Emphaze™ Biosupport Medium AB1; 3M Emphaze™ — Protein A Medium; 3M Emphaze™ Heparin Medium; 3M Emphaze™ Hydrazide Medium, monoclonal antibodies, specialty chemicals, support materials for purification and enzyme immobilization. Main products/instrumentation under R&D: Other chromatography media and biotechnological products.

1784

MB RESEARCH LABORATORIES

Principal products/instrumentation: Agriculture, biologicals, biomaterials, bioremediation, contract research/clinical trial products, natural products, nutraceuticals, vaccines, enzymes, specialty chemicals.

Add: P.O. Box 178 Spinnerstown, PA 18968

Main products/instrumentation under R&D: FIBEX Forages, VacciMatrix™, preclinical; Non-thrombogenic coatings, preclinical; Antibiofilm coatings.

Web site: www.mbresearch.com

Sealed and granted patents: Several.

1783

3M BIOAPPLICATIONS

Tel: (215) 536-4110 Fax: (215) 536-1816 E-mail: [email protected] President/CEO: George DeGeorge, Ph.D. Research director: Daniel R. Cerven R&D expertise: Contract toxicology and bioprocess engineering research; develop in vitro and in vivo assay systems to evaluate safety for biotechnology industry, pharmacology and biopharmacokinetics.

Add: 3M Center, St. Paul, MN 55144-1000

Joint ventures: Enviro-BioTech, INC.

Tel: (800) 257-7459

Technological expertise: C/TC, CH/S, DD, HTDS, contract safety evaluation (toxicology).

Fax: (651) 737-7776 Web site: www.3m.com President: Gregg K. McPherson, Ph.D. Research director: Dr. Jerald Rasmussen R&D expertise: Research and development of bioprocess automation recombinant DNA scaleup, large-scale cell/tissue culture using enzyme reactor technology, proprietary materials to manufacturers and researchers in biologicallyoriented companies; affinity chromatography products and R&D services.

Main products/instrumentation under R&D: In vitro assays for the determination and characterization of dermal and ocular irritation. In vivo brain microdialysis to assess neurotransmitter and amino acid levels in neurotoxicity and neurodegenerative models. Subsidiary bodies: GLP Analytical Testing Facilities: 140 Shartlesville Rd. Bemville, PA, 19506; NeuroDetective Behavioral Testing Labs: 1757 Wentz Rd., Spinnerstown, PA, 18968, Tel: (215) 536-4132.

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1785

FERGUSON PAPE BALDWIN ARCHITECTS

551

Main products/instrumentation under R&D: Analytical instruments, analytical instruments software, analytical chromatography, analyser.

Add: 701 B Street Suite 200San Diego, CA 92101-8101 Tel: (619) 231-0751 Fax: (619) 231-4396

1787

MCKESSON BIOSERVICES

E-mail: [email protected]

Add: 14665 Rothgeb Dr. Rockville, MD 20850

Web site: www.mbarch.com

Tel: (301) 315-8461

President/CEO: Kennon Baldwin

Fax: (301) 315-8460

Research director: Jim Ferguson

E-mail: [email protected]

R&D expertise: Architectural services for the biotechnology industry enterprises.

Web site: www.mckessonbio.com

Technological expertise: F, C/TC, R, H/CF, DD, GT, BI, RD, BA, GA, T, COC, PMC, architecture and engineering for R&D, pilot production and market launch facilities.

Research director: Robert Rice, Ph.D.

Principal products/instrumentation: Major facility examples: Advanced Tissue Sciences, IDEC Pharmaceuticals, Mallinckrodt Medical, Pharmingen, R. W. Johnson, Ligand Pharmaceuticals, Schumacher Chemical, HewlettPackard, La Jolla Cancer Research Foundation.

1786

McINTOSH ANALYTICAL SYSTEMS, INC.

Add: P.O. Box 1150 San Jose, CA 95108

President/CEO: Harrison N. Hoppes, Ph.D. R&D expertise: Biomedical research support development. Technological expertise: P/S, D-D, DD, PMC Principal products/instrumentation: Biologicals, chemicals, contract research/clinical trial products, pharmaceuticals, vaccines. Main products/instrumentation under R&D: Biomedical research support, support immunobilized enzymes.

1788

MCNAB INCORPORATED

Tel: (312) 907-8907

Add: 20 North MacQuesten Parkway Mount Vernon, NY 10550-1897

Fax: (312) 896-5780

Tel: (914) 699-1616

E-mail: [email protected]

Fax: (914) 699-1671

Web site: www.mcintosh.com

President/CEO: HA Teass, Jr.

President/CEO: Roger L. McIntosh

Research director: Minesh Patel

Research director: Roger L. McIntosh

R&D expertise: Development and manufacture of optical instruments.

R&D expertise: Design and manufacture of biomedical analytical instrument and analytical instrument software. Technological expertise: COC, CH/S, R Principal products/instrumentation: MTS — Modular Titration System.

Technological expertise: F, P/S, BA, PMC Principal products/instrumentation: In-line beer and wort particle counters (yeast, etc.), turbidity meters, forward, side, and back scatter, dual angle, extended range dual angle

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optical analyzers, haze meters, photospectrometers, laboratory haze meters, optical calibration standards, field calibrations, NIR alcohol and sugar analyzers, water quality analyzers, particle size analyzers (yeast and protein), fluorescence and color monitors, control loop preengineered skids (for pitching, cropping, transfer, dosing, and blending), support for Jacoby-Tarbox turbidity meters and laboratory work-ups and field service. Main products/instrumentation under R&D: Lab particle counter, optical technology devices, optical biosensor, optical instruments.

1789

MDI CONSULTANTS, INC.

Fax: (972) 2-996-1521 E-mail: [email protected] Web site: www.mofet.org.il Research director: Prof. Wilfred Stein R&D expertise: Development and manufacture of clinical assay kits for oncology. Technological expertise: DD, PP, AT Main products/instrumentation under R&D: Clinical tests, diagnostics, in vitro toxicology testing, clinical assay kit determines efficiency of anticancer drug treatment, Phase I; anti-carcinogen, cancer suppressor protein, cancer suppressor gene.

1791

MDS PHARMA SERVICES

Add: 55 Northern Blvd. Great Neck, NY 11021

Add: 300 Speedway Circle Lincoln, NE 68502

Tel: (516) 482-9001

Tel: (402) 476-0300

Fax: (516) 482-0186

Fax: (402) 476-0302

E-mail: [email protected]

E-mail: [email protected]

Web site: www.mdiconsultants.com

Web site: www.mdsharris.com

President/CEO: Anand Akerkar, Ph.D.

President/CEO: Robert B. Harris

Research director: Anand Akerkar, Ph.D.

Research director: Terry Lenehan, Ph.D.

R&D expertise: New drug R&D consulting on FDA approvals, GMPs, clinical trials, QAPs, mock audits, monitor studies, ISO programs and Cemark technical file assistance, technical file preparation.

Subsidiary of MDS Pharmaceutical Services.

Joint ventures: Midi Europa. Key sales market contracts: Taiwan, China, Mexico, Germany. Principal products/instrumentation: Quality assurance program for GMP compliance, ISO programs, quality control (QC) methods.

1790

M.D.R, TESTS, LTD.

Add: P.O. Box 80 Kiryat Arba 90100 Israel Tel: (972) 2-996-3880

R&D expertise: New drug comprehensive phase I, II, III and IV clinical trials research, SMO, bioanalytical, statistical, pharmacokinetic, pharmacology, pharmaceutics and data management services from facilities and offices in North America, Europe, and Asia. Principal products/instrumentation: Clinical tests, contract research/clinical trial products. Subsidiary bodies: Omaha, Nebraska; Phoenix, Arizona; Belfast, Northern Ireland; Beijing, China.

1792

MDS PHARMA SERVICES

Add: The Triad 2200 Renaissance Blvd Suite 400 King of Prussia, PA 19406-2755

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Tel: (610) 239-7900 Fax: (610) 239-7111 E-mail: [email protected] Web site: www.mdsps.com President/CEO: Ian Lennox Research director: Doug Squires/Susan Thornton R&D expertise: Drug discovery, design and development, preclinical, early clinical research (Phase I-IIa), bioanalytical, global clinical research (Phases IIb-IV), and central laboratories around the world. Technological expertise: DD, D-D, C/TC Principal products/instrumentation: Clinical tests, contract research/clinical trials products, in vitro toxicology testing method, specialty chemicals, reagents, nutraceuticals, pharmaceuticals, vaccines.

553

of breast, colorectal, kidney, avarion, prostate cancers, Phase II; MDX-447 biospecific antibody to treat head and neck, renal cancers, Phase II/III; MDX-11, Phase II; MDX-22, Phase II; MDX-240 completed Phase I/II; MDX-33, autoimmune disease, idiopathic thrombocytopenic purpura, Phase II, 2008; MDX-RA immunotoxin (MAb) for prevention of secondary cataract, Phase III/IV. Sealed and granted patents: Prodrug compounds with an isoleucine, 7,115,573, U.S.; Therapeutic compounds comprised of anti-FC receptor binding agents, 6,365,161, U.S.; Human monoclonal antibodies to FC gamma receptor (CD32), 20070253958, U.S.

1794

MEDGENE SCIENCE

Add: 14 Rue Scandicci Pantin F-93508 France Tel: (33) 1- 4942-2029

1793

MEDAREX, INC.

Add: 1545 Route 22 East P.O. Box 992Annandale, NJ 08801-0992 Tel: (908) 713-6000 Fax: (908) 713-6013 Web site: www.medarex.com President/CEO: Donald L. Drakeman, J.D., Ph.D. Research director: Yashwant Deo, Ph. D. Key license and trade contracts: Ciba Geigy, Ltd., Merck KgaA, Centeon, LLC. R&D expertise: Development and manufacture of biological drugs. Technological expertise: C/TC, H/CF Principal products/instrumentation: Research reagents, including AML 2-23, PM-81, 3G8, 1V3, PC-251, 32.2, 22, 197; other biotechnology drug products. Main products/instrumentation under R&D: MDX-210 biospecific antibody for treatment

Fax: (33) 1-4942-2028 President/CEO: Gerard Seroussi R&D expertise: Development and manufacture of antibodies and other biotechnology medicines. Technological expertise: PA, T, AB, DD, GA, GT, H/CF Principal products/instrumentation: BTX Electroporators, GEN-ETRONICS, Antibodies, NEOMARKERS; Antibodies, SEROTEC, complete antibodies, natural antibodies, monoclonal antibodies, polyclonal antibodies.

1795

MEDIA CYBERNETICS, LP.

Add: Media Cybernetics, Inc.4340 East-West Hwy, Suite 400 Bethesda, MD 20814-4411 Tel: (301) 495-3305 Fax: (301) 495-5964 E-mail: [email protected] Web site: www.mediacy.com

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President/CEO: Michael Galvin R&D expertise: Development and manufacture of image analysis and biotechnological scientific computing software. Technological expertise: CH/S, BTS, BME, AMS Principal products/instrumentation: ImagePro Plus, Gel-Pro Analyzer, Materials-Pro Analyzer. Array-pro analyzer, software packagon, image maker, image analyzed microscopy. Main products/instrumentation under R&D: Array-Pro analyzer, software package, image maker, image analyzed microscopy.

1796

MEDIATECH, INC.

Additional serum-free/protein-free media formulations.

1797

MEDICA, INC.

Add: 336 Encinitas Blvd. Ste. 200 Encinitas, CA 92024 Tel: (760) 634-5440 Fax: (760) 634-5442 E-mail: [email protected] Web site: www.medica-dx.com President/CEO: Jarka Barti Research director: Rhodora Chapoco R&D expertise: Manufacture and marketing of test kits and their components for detection of certain autoantibodies in human sera by immunofluorescence.

Add: 9345 Discovery Blvd.Manassas, VA 20109

Technological expertise: C/TC, FL, AB, DKHC

Tel: (800) 235-5476

Principal products/instrumentation: Test kits and components—ANA, A-nDNA-A, AMA, ASMA, APCA, ASA, AEmA, ACA, ATA, APICA.

Fax: (703) 471-0363 E-mail: [email protected] Web site: www.cellgro.com President/CEO: James E. DeOlden Research director: Matt Maupin R&D expertise: Leading cGMP R&D of sterile cell culture solutions to the biopharmaceutical industry. Key sales market contracts: BioLife Technologies, INC. (a subsidiary of CryoMedical Sciences, INC.), Fisher Scientific, Wisent, INC. ICN Biomedicals, VWR, SciQuest, Cole Parmer. Technological expertise: H/CF, BA, C/TC Principal products/instrumentation: Cell culture media and supplements, cellgro; Insect cell culture products, Insectagro; Serumfree/ protein-free cell culture media. Main products/instrumentation under R&D: Cell/tissue/organ preservation solutions;

Main products/instrumentation under R&D: ANCA, components for detection of certain autoantibodies.

1798

MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.

Add: 5F Sumitomoshoji Marunouchi Bldg., 5-10 Marunouchi 3-chome, Naka-ku, Nagoya 460-0002 Japan Tel: (81) 52-971-2081 Web site: www.mbl.co.jp President/CEO: Sachiko Suno Research director: Y Omura R&D expertise: R&D of diagnostics for autoimmune diseases; production and supply of humanized antibodies for therapeutics, etc.

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R&D collaboration: Roche Diagnostics. Key sales market contracts: Roche Diagnostics. Key license and trade contracts: Roche Diagnostics ZMMCO. Technological expertise: PA, Q, C/TC, H/CF, P/S, RD Principal products/instrumentation: Hep-2 slide for detecting antinuclear antibodies, MBL (in Japan); ELISA kits for ENA (Extractable Nuclear Antigen), KASSAY (in Japan); Monoclonal antibodies against apoptosis, concerned molecules, BCA (in Japan). Main products/instrumentation under R&D: HMG ELISA/anti-HMG ELISA; anti-BP 180 ELISA, RCASL ELISA, ST-2; ELISA, IL-18 ELISA, EDEN ELISA. Sealed and granted patents: U.S. patent no. 5,541,271 (Duke patent), U.S. patent no. 4,751,181 (Duke patent), U.S. patent no. 5,721,110 (Duke patent), U.S. Pat No. 5,030,667 (INSERMLKM-I Patent); methods for selecting proteins that are readily presented as antigens on dendritic cells, 20080064048, U.S.

1799

MEDICAL INNOVATIONS GROUP LTD.

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Principal products/instrumentation: ELISA assays for breast cancer (M.S.A.), ovarian cancer (CA.S.A.); anti-cardiolipin antibodies; IgG and IgA antibodies to gliadin to screen for coeliac disease. Main products/instrumentation under R&D: MS therapeutic agents. 1800

MEDICAL SCIENCE SYSTEMS, INC.

Add: 100 NE Loop 410, Ste. 820 San Antonio, TX 78216-4749 Tel: (210) 349-6900 Fax: (210) 384-3350 Web site: www.medscience.com President/CEO: Paul J. White, J.D. Research director: Kenneth Korman, DDS, Ph.D. R&D expertise: Development, manufacture and commercialization of genetic tests, genetic testing analysis and related novel products. Joint ventures: Section of Molecular Medicine at the University of Sheffield, U.K. Key sales market contracts: MedicardantFrance Technological expertise: BI, CH/S

Add: Birchwood House. 55 Vanguard Way, Shoeburyness, Essex, SS3 QQY, U.K. Tel: (61) 2-9439-2673 Web site: www.medicalinnovations.co.uk President/CEO: Sir James Killen

Principal products/instrumentation: Genetic susceptibility test for periodontal disease, PST trademark, diagnostic reagents. Main products/instrumentation under R&D: Genetic susceptibility tests for osteoporosis and coronary artery disease.

Research director: J. Colder, Ph.D.

Subsidiary bodies: Flagstaff, Arizona.

R&D expertise: Development and manufacture of cancer diagnostics and therapeutics.

Sealed and granted patents: U.S. patents: periodontal for osteoporosis susceptibility test; biofusion biologic modeling technology.

Key sales market contracts: Medac, Bertec Enterprise Co., Baxter Diagnostics, Poli Diagnostic. Key license and trade contracts: R-Biopharm, Transia-Diffchamb, Cortecs. Technological expertise: C/TC, H/CF

1801

MEDICAL SUPPLY CO., LTD.

Add: Darnastown Ind. Park Mulhuddart Dublin 15 Ireland

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Tel: (353) 1-822-4222 Fax: (353) 1-822-4100

Main products/instrumentation under R&D: Healthcare medicines, anti-aging agents.

E-mail: [email protected] Web site: http://www.medical-supply.ie/

1803

MEDICHEM RESEARCH, INC.

President/CEO: B. Scully Research director: Dr. B. Lannon R&D expertise: Laboratory diagnostics, biotechnology, pharmaceutical research.

Add: 2501 Davey Road Woodridge Illinois 60517 Tel: (630) 783-4000

Joint ventures: ALP (Allied Laboratory Products), North Ireland.

Fax: (630) 783-4646

Principal products/instrumentation: Biomerieux, Promega, Immucor, Pierce, Tecan, ICN, Bibby Sterilin, ALC/Jouan.

President/CEO: Michael T. Flavin

Main products/instrumentation under R&D: Milk sample container, diagnostic reagents, diagnostic test kits, biotech medicines. Sealed and granted patents: Milk sample container.

1802

MEDICAL TECHNOLOGY AND PRACTICE PATTERNS INSTITUTE

Add: 4733 Bethesda Ave., Ste. 510 Bethesda, MD 20814 Tel: (301) 652-4005

E-mail: [email protected] R&D expertise: Contract research and development of biochemicals specializing in custom organic synthesis in the scale ranging from milligrams to 15 kilograms. Technological expertise: COC, P/S, SMC, SY Principal products/instrumentation: Contract R&D products, biochemicals, organic reagents. Main products/instrumentation under R&D: Medichem synthesis from milligrams to 15 kilograms.

1804

MEDICO PHARMA TRADE

Fax: (301) 652-8335

Add: 4, Zarnzam Str. Dokki, Giza Cairo Egypt

E-mail: [email protected]

Tel: (20) 2-749-8311

Web site: www.mtppi.org

Fax: (20) 2-748-1468

President/CEO: Dennis J. Cotter

E-mail: [email protected]

Research director: Seymour Perry, M.D., MACP

President/CEO: Dr. Hussein Ismail

R&D expertise: Healthcare products research; healthcare technology assessment.

R&D expertise: Development and supply of diagnostics, fine chemicals and biopharmaceutical.

R&D collaboration: Walter Reed Army Institute of Research. Technological expertise: PG, PMC, BI, BA, CB, DD, D-D Principal products/instrumentation: Contract R&D products; healthcare products.

Research director: Dr. Hussein Ismail

Joint ventures: Molecular biology, reagents and instruments. Technological expertise: AF, AB, BI, BA, BS, CB, C/TC, DD, GA, P/S, CC, E, F, PMC, PB, PG, PA, Q, SMC, GT, G, HTDS, H/CF

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Principal products/instrumentation: Enzymes, probes, primers (AP Gene-Sigma 1990), extraction kit, vaccines, molecular biology reagents. Main products/instrumentation under R&D: Fine chemicals, diagnostic enzyme, diagnostic kits, diagnostic drugs.

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557

MEDICULT

Add: Mollehaven 12B 4040 Jyllinge Denmark Tel: (45) 46-790-200 Fax: (45) 46-790-300 E-mail: [email protected] Web site: www.medicult.com

1805

MEDICORP, INC.

Add: 5800 Royalmount Montreal Quebec H4P 1K5 Canada Tel: (514) 733-1900 Fax: (514) 733-1212 E-mail: [email protected] Web site: www.medicorp.com President/CEO: Elliott Block, Ph.D. Research director: Pierre Du Ruisseau, Ph.D. R&D expertise: Cell and tissue culture research; design of PHT Immunotherapy for AIDS; manufacture and marketing clinical diagnostics and research reagents. Joint ventures: Medicorp & Dianon systems own Decision Diagnostics, INC. R&D collaboration: Cenfold Holdings PHT AIDS therapy. Key sales market contracts: ICN Biomedical, Becton-Dickinson Microbiology, Biosource International, Argene Biosoft, BYK-Sangtec, Alifax, Anand Bros., Eiken, Wako, Sangtec, Izasa, Accurate, Chemicon. Technological expertise: PA, RD, H/CF, C/TC, GT Principal products/instrumentation: Full line of RIA, Elisa and Microbiology tests, FBS, research kits and reagents, supplies and equipment. Main products/instrumentation under R&D: PHT immunotherapy for AIDS, in Phase III clinical trials. Sealed and granted patents: U.S. # 4,863,730 for immunotherapy for AIDS; other pending.

President/CEO: Henrik B. Krogen Research director: Henrik Malmos R&D expertise: Manufacture and marketing of synthetic cell culture media, media for cell culture and assisted reproduction. Technological expertise: F, TE, BA, C/TC, H/CF, P/S Principal products/instrumentation: RenCyte BMK, RenCyte CHO, RenCyte Fibroblast, RenCyte Hybridoma. Main products/instrumentation under R&D: RenCyte CNS, ready to launch; RenCyte Vero, in development; RenCyte 293, in development. Subsidiary bodies: U.K.: Medi-Cult (U.K.) Ltd., The Old Tannery, Oakdene Road, Redhill, Surrey RH16BT, Tel: (44) 173-776-5500, Fax: (44) 173-776-5511, [email protected], Contact: Sandra Hulme; U.S.: Medi-Cult, INC. 30 Main St., #26, Ashland, MA 01721, Tel: (508) 881-9450 or (800) 324-5067, Fax: (508) 881-9469, medicult@ pop.ma.ultranet.com, Contact: Anthony M. Morrison; France: Medi-Cult France, 48, Rue Quivogne, 69002 Lyon, France, Tel: (33) 4-7256-4800, Fax: (33) 4-7256-4801, Contact: Denis Azra. Sealed and granted patents: SSR — synthetic serum replacement.

1807

MEDICURE, INC.

Add: 2-1250 Waverley Street Winnipeg, Manitoba, CANADA R3T 6C6 Tel: (204) 487-7412

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Fax: (204) 488-9823 E-mail: [email protected] Web site: www.medicure.com President/CEO: Albert D. Friesen, Ph.D. Research director: Albert D. Friesen, Ph.D. R&D expertise: Research of biotechnology medicines and natural compounds for cardiovascular disease, drug discovery and drug development, discovery and development of cardiovascular therapeutics. Technological expertise: D-D, SMC, CB Markets: Pharmaceuticals Main products/instrumentation under R&D: MC-1, preclinical, cardiovascular therapeutics, R&D; natural compounds, for cardiovascular disease treatment.

1808

MEDIGENE AG

Add: Lochhamer Str. 11 82152 Martinsried Germany Tel: (49) 89-8565-2920 Fax: (49) 89-8565-2920 E-mail: [email protected]

Principle products/instrumentation: Kunecatechins (Veregen), topical treatment of external genital and perianal warts (Condylomata acuminata) in immunocompetent patients 18 years and older, 2008. Main products/instrumentation under R&D: Viral vaccine, cervical intraepithelial neoplasia, Phase II; Tumor vaccine, malignant melanoma, preclinical; Etomoxir, congestive heart failure, Phase II; Polyphenon E, genital warts, Phase II. Sealed and granted patents: 13 patents, another 25 patent applications (patents cover cervical cancer vaccine, melanoma vaccine, its lead products Etomoxir and Polyphenon™ as well as CVLP-technology, rAAV technology and ITD program).

1809

MEDIGENE, OY.

Add: Bioteknia, Neulanienentie 2 L9 Kuopio FIN-70210 Finland Tel: (358) 17-240-875 Fax: (358) 17-240-876 President/CEO: Hanna Poutiainen

President/CEO: Dr. Peter Heinrich

R&D expertise: Gene therapy and therapy technology research, coronary heart disease drug manufacture.

Research director: Dr. Johanna Holldack

Technological expertise: Q, DD, GT

R&D expertise: Research, development and manufacture of biotechnological medicines and vaccines of tumors and cardiac diseases.

Principal products/instrumentation: Contract research/clinical trial products, DNA, DNAse, RNAse contamination test, oxidized LDL autoantibody test, GMP VWS and DNA contract manufacturing products.

Web site: www.medigene.de

Key license and trade contracts: Aventis Pharma for the joint development of MediGene’s tumor vaccine to treat malignant melanoma. Schering AG for the clinical development and commercialization of MediGene’s viral vaccine for treatment of cervical intraepithelial neoplasia (CIN) and cervical cancer caused by HPV. Technological expertise: BI, C/TC, GT, RD, G, LP, GA

Main products/instrumentation under R&D: Gene therapy, coronary heart disease therapeutics.

1810

MEDI-JECTOR

Add: Antares Pharma, Inc.13755 First Avenue North Suite 100 Minneapolis, MN 55441

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Tel: (763) 475-7701 Fax: (763) 476-1009 E-mail: [email protected] Web site: www.mediject.com President/CEO: Franklin Pass, M.D. Research director: Peter Sadowski, Ph.D. R&D expertise: Research and manufacture of needle-free drug delivery devices. Key license and trade contracts: Faring Human Growth Hormone Europe; TEVA cophonse treatment of MS nonexclusive; JCR Pharmaceuticals human growth hormone, Japan; Becton Dickinson — joint development of new system for insulin delivery and disposable needlefree syringes; Schering-Plough — Alpha interferon; SmithKline Beecham — research agreement; Bio Technology General — hGH; Organon — development agreement, hormone replacement.

559

of infectious diseases and products for transplantation medicine. R&D collaboration: Human Genome Sciences, INC., Washington University, Biotransplant, INC., Rockefeller University, Georgetown University. Key sales market contracts: Abbott Labs; SmithKline Beecham. Key license and trade contracts: American Home Products, Biotransplant, INC. Technological expertise: PA, Q, F, P/S, RD, PB, H/CF, C/TC Principal products/instrumentation: Biologicals vaccines, CytoGarn; Respigam; Synagis® (monoclonal antibody), for treatment of respiratory syncytial virus (RS virus); Synagis MEDI-493 humanized RSV mAb, for treatment of respiratory syncytial virus.

Tel: (301) 398-0000

Main products/instrumentation under R&D: MEDI-491 parvovirus B 19 vaccine, treat anemia; MEDI-507 humanized mAb to treat graftversus-host disease (GVHD), Phase III; HPV vaccine, head tumor, Phase II; UTI vaccine, HPV vaccine, cervical cancers; E.Coli vaccine for treatment of urinosexual infection, Phase II, 2008; Vitaxin anti-angiogenesis mAb (angiogenesis inhibitor) to treat leiomyosarcoma, Phase II/III, 2008. Three anti-cancer monoclonal antibodies into clinical development in the past six months 2009, these include Medi573, a fully human anti-insulin-like growth factor I and II antibody; Medi-575, a fully human anti-platelet-derived growth factor receptor antibody; and Medi-547, an antibodydrug conjugate targeting EphA2, 2009.

E-mail: [email protected]

Subsidiary bodies: Frederick, MD, U.S.A.

Web site: www.medimmune.com

Sealed and granted patents: Methods of priming the immunogenic activity of vaccines useful for eliciting a protective immune response. 6,962,701, U.S.; Chaperone and adhesion proteins. vaccines, diagnostics and method for treating infections. 6,500,434, U.S.; Methods of administering/dosing anti-RSV

Technological expertise: DD Principal products/instrumentation: MediJector Choice, Needle-free Syringe, human growth hormone, alpha interferon, new system for insulin delivery, disposable needle-free syringes. Main products/instrumentation under R&D: Needle-free drug delivery syringe needle.

1811

MEDIMMUNE, INC.

Add: 35 West Watkins Mill Road Gaithersburg, MD 20878

President/CEO: David M. Molt Research director: James E Young, Ph.D. Subsidiary of ASTRA ZENECA. R&D expertise: Development and manufacture of therapeutics and vaccines for the prevention

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antibodies for prophylaxis and treatment. 6,855,493, U.S.

1812

MEDI-NOVA, LTD.

Add: 159Ygal Alon St. Office 222 Tel Aviv 67443 Israel

Principal products/instrumentation: Reagents, human genome project, organ transplants/ culture, natural products, biosensor, vaccines, monoclonal antibodies, polyclonal antibodies, specialty chemicals. Main products/instrumentation under R&D: Molecular biology reagents, immunoregulators, immunostimulants.

Tel: (972) 3-696-4030 Fax: (972) 3-695-8566 President/CEO: Harm Shafrir

1814

MEDIS-EL.LTD.

R&D expertise: Development, manufacture and marketing of medical and human biotechnology products, international marketing of telemedicine systems, R&D and marketing of human genetics and molecular biology based diagnostic systems.

Add: 2 Yodfat Street, P.O. Box 1112 Global Park Lod 71291 Israel

Principal products/instrumentation: Contract R&D products, reagents, vaccines, specialty chemicals.

Web site: www.iaesi.org.il

Main products/instrumentation under R&D: Human biotechnology medicines, telemedicine systems.

1813

MEDINOVA SCIENTIFIC AS

Add: Produktionsvej 26 DK-2600 GLOSTRUP Denmark Tel: (45) 3956-2000 Fax: (45) 3956-1942 E-mail: [email protected]

Tel: (972) 8-918-8600 Fax: (972) 8-920-0024 E-mail: [email protected] Research director: Yael Schippenbaver, Ph.D. R&D expertise: Research, development manufacture and marketing of medical diagnostics and research instruments for early detection of cancer, immunodiagnostic and cell research, EEG instrumentation for hospitals/clinics and for field brain monitoring. Principal products/instrumentation: Contract R&D instrumentation, diagnostic/research instruments, anti-cancer drug, cell culture products. Main products/instrumentation under R&D: Instruments for early detection of cancer, immunodiagnostic reagents.

Web site: www.medinova.dk President/CEO: Nils Erik Frandsen R&D expertise: Research of reagent, mainly molecular biology, immunology, microbiology and haematology, related novel products manufacture. Key sales market contracts: NEB, FMC Bioproducts, Amer Diag., AMRESCO, Worthington, Funn-zymes, BioConcept, 5 Prime 3 Prime, RAMCO.

1815

MEDIX BIOCHEMICA

Add: Asematie 13 Kauniainen 02700 Finland Tel: (358) 9-547-680 Fax: (358) 9-505-3441 E-Mail: [email protected] Web site: www.medixbiochemica.com President/CEO: Ismo Raman

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Research director: Sari Tikanoja

Research director: Michael Turanchik

R&D expertise: R&D/manufacture of monoclonal antibodies for in vitro diagnostic use, rapid tests.

R&D expertise: Development, manufacture and marketing of on-site diagnostic test kits, contract R&D and manufacture of biotechnology drug products.

Technological expertise: H/CF, MAE Principal products/instrumentation: Monoclonal antibodies, rapid test technique, contract manufacturing products. Main products/instrumentation under R&D: Monoclonal antibodies for in vitro disease diagnosis.

1816

MEDIX BIOTECH, INC.

Add: 1531 Industrial Rd. San Carlos, CA 94070 Tel: (415) 594-0513 Fax: (415) 594-0571

Key sales market contracts: Various exclusive and nonexclusive distribution agreements. Technological expertise: SMC, BA, HTDS, P/S Principal products/instrumentation: EZScreen test kits, VERDICT test kits for drugs of abuse, RECON test kits for agents of biological origin; Profile multi-test drugs of abuse kits, vaccines, antibodies. Main products/instrumentation under R&D: Additional VERDICT products, on-site diagnostic test kits. Subsidiary bodies: MEDTOX Laboratory (St. Paul, MN).

President/CEO: Bill Leiva Research director: Delia Bethell R&D expertise: R&D and manufacture of immunoassay and immunochemistry reagents, EIA kits, and rapid test devices. Technological expertise: PA, H/CF, MAE, AB Principal products/instrumentation: Monoclonal and polyclonal antibodies, EIA reagents, Contrast hCG (Urine/Serem) (rapid particlebased, one-step test), vaccines, FAStrep A. Main products/instrumentation under R&D: Infectious mononucleosis (rapid test), hCG dipstick, Contrast™ Strep A, rapid test devices, EIA kits, immunochemistry reagents, immunoassays.

1817

MEDTOX DIAGNOSTICS, INC.

Add: 1238 Anthony Rd. Burlington, NC 27215 Tel: (336) 226-6311 Web site: www.medtox.com President/CEO: Harry McCoy

1818

MEGABIOS CORP.

Add: 863A Mitten Rd. Burlingame, CA 94010 Tel: (650) 697-1900 Fax: (650) 652-1990 President/CEO: Benjamin F. McGraw, III, Pharm.D. Research director: Rodney Pearlman, Ph.D. R&D expertise: Development and manufacture of non-viral gene delivery systems, genebased therapeutics designed for the treatment or prevention of genetic and acquired diseases, several in vivo, non-viral gene delivery systems to address potential therapeutic applications using a variety of therapeutic genes, etc. R&D collaboration: Glaxo-Wellcome (1994), Eli Lilly (1997). Technological expertise: GT, PG Main products/instrumentation under R&D: MB 100 Inhalation — cystic fibrosis, Phase I/II; Asthma, preclinical; Lung infectious

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diseases, research; lung inflammation, research; mucosal immunization, research. MB200 Intravenous Injection — angiogenesis inhibition (cancer), preclinical; Angiogenesis inhibition (non-cancer), preclinical; Metastatic cancer (non-angiogenesis inhibition), preclinical; Protein replacement, research, Cardiovascular disease, research; Inflammatory disease, research. MB300 Direct Injection — Cancer (various genes), Phase I/II. MB400 — intramuscular, intradermal, subcutaneous, intravenous, preventive and therapeutic vaccines, research. MB500 Intravenous — Infectious diseases and cancer, research. MB600 Direct Injection — Neurodegenerative diseases and cancer, research. MB700 Intraperitoneal — Cancer (BRGA1), preclinical; Cancer (various genes), research. MB800 Intra-articular — Rheumatoid arthritis, preclinical; Osteoarthritis, research; Cartilage repair, research. Cystic Fibrosis, CFTR, Phase I/II; Cancer: Melanoma, IL2/SEB, Phase I/II; non-viral gene delivery systems, gene therapeutics for treatment or prevention of genetic and acquired diseases. Sealed and granted patents: Megabios holds an exclusive license to U.S. patent #5,641,662 and # 5,756,353 covering aerosol delivery of genes to the lungs using canonic lipids. U.S. patent #5,705,151 issued describing the use of gene-based therapeutics, incorporating a cytokine gene together with a superantigen gene for the treatment of cancer. Patents #5,766,585, #5,705,655, #5,736,395, #5,698,721, #5,776,908 and #5,665,879 issued.

1819

MEISSNER FILTRATION PRODUCTS, INC.

Add: 4181 Calle Tesoro Camanllo, CA 93012 Tel: (805) 388-9911 Fax: (805) 388-5948 Web site: www.meissner.com President/CEO: Christopher Meissner

R&D expertise: R&D, manufacture and marketing of advanced microfiltration materials, products and systems. Key sales market contracts: Worldwide distribution network. Technological expertise: F, P/S, BA, C/TC, CH/S Principal products/instrumentation: New SteriLUX™ hydrophilic PVDF, Steridyne™ hydrophobic PVDF membrane filters for sterilizing liquid and gas applications, STy-LUX polyethersulfone filters for sterile filling, mycoplasma removal; Ultradyne® filters for fermentor air, sterile vents, gases; Chemdyne filters for ultrapure solvents and chemicals; SFE filters for small batch sterile processing and sterile venting; Capsule filters in 4 sizes; Disc filters; Sanitary filter housings. Main products/instrumentation under R&D: Membrane filtration material systems. Subsidiary bodies: Channel Islands, CA.

1820

MELOTEC S.A.

Add: Pare Tecnologic Del Valles Cerdanyola Barcelona 08290 Spain Tel: (34) 93-582-0166 Fax: (34) 93-580-1438 E-mail: [email protected] President/CEO: Alberto Mesanza Research director: Horacio Sack R&D expertise: Development and manufacture of enzyme immunoassays (EIA) for the diagnosis of infectious and parasitic diseases, hormones, tumor markers and veterinary diseases. Restriction endonucleases. Technological expertise: E, PA, P/S, ET, ERT Principal products/instrumentation: Enzyme immunoassays (EIA), restriction endonucleases, enzyme-linked immunosorbent assay (ELISA).

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MEMBRANE FILTRATION PRODUCTS, INC.

in public water supplies, membrane filter, membrane filter bioreactor, membrane filtration manifold.

Add: 314 N. River Street, Seguin, Texas 78155

Sealed and granted patents: 4,790, 942; 4,867,878; 4,876,013; 4,906,379; 4,911,847.

1821

Tel: (800) 647-5758 Fax: (830) 379-0720 E-mail: [email protected] Web site: www.membrane-mfpi.com President/CEO: Don Keil Research director: Dan Harmon

1823

MEMOREC STOFFEL GMBH

Add: Stockheimer Weg 1 Cologne, NRW 50289 Germany Tel: (49) 22-195-0480

R&D expertise: Manufacture and marketing of laboratory dialysis products.

Fax: (49) 22-195-0488

Key sales market contracts: Produce “Fisherbrand Dialysis Tubing” for Fisher Scientific.

Research director: Dr. Marcus Conradt

Technological expertise: P/S, BME Principal products/instrumentation: Dialysis membranes and accessories, dialysis membranes, Micro dialyzers, laboratory-scale dialysis membranes.

President/CEO: Dr. Boris Stoffel R&D expertise: Drug target discovery and development; research of expression profiling solutions, including sage and piqor CDNA systems, products manufacture. R&D collaboration: Cheragen AG, Grohmarm Engineering GmbH, FH- ITA. Key sales market contracts: Biozym.

1822

MEMBREX, INC.

Add: 155 Route 46 W. Fairfield, NJ 07004 Tel: (201) 777-5242 Fax: (201) 575-7011 President/CEO: Malcolm Kahn Research director: Dr. Len Hodgins R&D expertise: Design and development of membrane filtration (such as sample clarification, particulate removal, solids concentration and washing to name a few), related products manufacture. Joint ventures: Membrex/ImmuCell Corporation. Development of a method to detect C. parvum in public water supplies. Technological expertise: F, C/TC, P/S, BA Principal products/instrumentation: Benchmark, Pacesetter. Main products/instrumentation under R&D: Development of a method to detect C. parvum

Key license and trade contracts: Gentype Molecular Oncology, INC. Technological expertise: T, BI, C/TC, G, PG, P/S Principal products/instrumentation: Piqorth array systems, Sage, Tox Pro DB, drug target discovery technique, gene expression profiling solutions. Main products/instrumentation under R&D: Tox Pro DB, drug target discovery technologies. Subsidiary bodies: Animal facility for mice and rats. Sealed and granted patents: Twenty drug target patients tried; others pending.

1824

MENDEL BIOTECHNOLOGY, INC.

Add: 3935 Point Eden Way Hayward, California 94545-3720

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Tel: (510) 264-0280 Fax: (510) 264-0254 E-mail: [email protected] Web site: www.mendelbio.com President/CEO: David Summa

Aivlosin (veterinary-antibiotic); Calsitoriol (Vitamin D3 derivative for osteoporosis treatment); cyclodetrins, xanthan gum (food additive). Main products/instrumentation under R&D: Fine chemicals.

Research director: Guo-Liang Yu R&D expertise: R&D of plant functional genomics, related novel products manufacture. R&D collaboration: Monsanto, Savia. Key license and trade contracts: WeatherGard for freezing tolerance available to license.

1826

MERCK & CO., INC.

Add: One Merck Dr. Whitehouse Station, NJ 08889-0100 Tel: (908) 423-1000

Technological expertise: BI, G, RD, R, Q, T

Web site: www.merck.com

Main products/instrumentation under R&D: WeatherGard for freezing tolerance specialty chemicals in plants, plant functional genomic sequencing.

President/CEO: P. Roy Vagelos, M.D.

Sealed and granted patents: CBF for freezing and drought tolerance; biochemistry-related polynucleotides and polypeptides in plants. 7,135,616, U.S.

1825

MERCIAN CORPORATION

Add: 1-5-8, Kyobashi Chuo-ku Tokyo 1048305 Japan Tel: (81) 3-3231-3917 E-mail: [email protected] Web site: www.mercian.co.jp President/CEO: Tadao Suzuki Research director: Kunio Isshiki, Ph.D. R&D expertise: Manufacturing and marketing of fine chemicals and pharmaceuticals. Joint ventures: Shenzhen Main Luck Pharmaceuticals, INC. (P. R. China). Technological expertise: AF, BA, E, F, CB, GA, P/S, RD Principal products/instrumentation: Josamycin (antibiotics); Aclarubicin, Pirarubicinm Doxorubicin (anthracycline anti-cancer), Kasugamycin (rice fungicide); Tylosin,

Research director: Edward M. Scolnick, M.D. R&D expertise: Discovery, research and develop of biotechnological medicines, manufacturing of antiviral drugs. Joint ventures: Johnson & Johnson/Merck Consumer Pharmaceuticals; Astre/Merck; DuPont Merck Pharmaceutical Company. Technological expertise: DD, D-D, BC, BS, HTDS, HTDS, RD Principal products/instrumentation: Vaseretic; recombinant hepatitis B vaccine, Recombivax HB®; Mefoxin; Pepcid; Prinivil; Proscar; Vasotec; Timoptic; Zocor; Mevacor; M-M-R II; Noroxin; Pedvax HIB; Comvax haemophilus B conjugate (meningococcsl protein conjugate ) and hepatitis B recombinant vaccine for hepatitis B and influenzal hemophilus diseases; Emend (Aprepitant), in combination with other antiemetic agents, for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy, including highdose cisplatin, 2003; raltegravir potassium (isentress) for the treatment of HIV-1 infection in combination with other antiretroviral agents in treatment-experienced adults who have evidence or viral replication and HIV-1 strains resistant to multiple antiretroviral agents (oral),

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2007; sitagliptin phosphate (Januvia), glycemic control in patients with type 2 diabetes mellitus, 2006; Vorinostat (Zolinza), treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma (VTVL), 2006; shingles vaccines (Zostavax), treat herpes zoster, 2006; rotavirus vaccines (RotaTeq), protection xoloproctitis, 2006; HPV vaccines (Gardasil), 2006.

indolocarbazole glycosides. 6,559,299, U.S.; Antigen library immunization. 6,541,011, U.S.

Main products/instrumentation under R&D: HPV vaccine for prevention of cervical tumor, Phase III; and of human papilloma virus, Phase III.

Fax: (49) 6-151-722-000

Sealed and granted patents: Method for measuring human neurokinin-3 receptor ligand binding. 6,348,570, U.S.; Chromophore containing compounds and their use in determining interleukin-1 beta convertase activity, 6,348,570, U.S.; DNA molecules encoding the melanocortin 4 receptor protein from rhesus monkey. 6,573,070, U.S.; DNA molecules encoding the melanocortin 5 receptor protein from rhesus monkey. 6,645,738, U.S.; Enhanced system for construction of adenovirus vectors. 6,855,534, U.S.; Synthetic HIV gag genes. 6,696,291, U.S.; Process for the scaleable purification of plasmid DNA. 6,797,476, U.S.; Transgenic mouse expressing non-native wild-type and familial Alzheimer’s disease mutant presenilin 1 protein on native presenilin 1 null background. 6,452,065, U.S.; Gamma three protease, 7,135,307, U.S.; Recombinant hepatitis B surface antigen. 7,098,309, U.S.; DNA molecules encoding Macaca mulatta androgen receptor. 7,060,463, U.S.; Saratin for inhibiting platelet adhesion to collagen. 6,881,722, U.S.; Adenovirus carrying gag gene HIV vaccine. 6,78,7351, U.S.; Preservatives for vaccines. 6,790,445, U.S.; Gene therapy for inhibition of angiogenesis. 6,375,929, U.S.; Process for making human papillomavirus virus-like particles with improved properties. 6,436,402, U.S.; Virtual wells for use in high throughput screening assays. 6,565,813, U.S.; Preparation and isolation of

President/CEO: Prof. H. J. Langmann

1827

MERCK KGAA

Add: Frankfurter Str. 250 64293 Darmstadt Germany Tel: (49) 6-151-720 E-mail: [email protected] Web site: www.merck.de Research director: Dr. Lues R&D expertise: Development and manufacture of pharmaceutical laboratory products, laboratory supply, specialty chemicals. Technological expertise: E, F, RD, COC, DD, D-D, HTDS, P/S, SY Principal products/instrumentation: Pharmaceuticals, raw materials, reagents, diagnostics, chromatographic materials and equipment, specialty and fine chemicals, pigments, cosmetic raw material, liquid crystals.

1828

MERIDIAN BIOSCIENCE, INC.

Add: 3471 River Hills Dr. Cincinnati, OH 45244 Tel: (513) 271-3700 Fax: (513) 271-3762 Web site: www.meridianbioscience.com President/CEO: Jack Kraeuder Research director: Arthur Yi R&D expertise: Development and manufacture of new diagnostics and therapeutics. Technological expertise: HTDS, CS Principal products/instrumentation: Diagnostics Para-Pak; Premier EHEC; Premier and ImmunoCard C. dimcille; Premier and Merifluor

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Giardia; ImmunoCard Rotavirus; ImmunoCard Mono; MONOLERT; ImmunoCard and Meritec Mycoplasma; Cryptococcal Antigen Latex Agglutination System (CALAS). Main products/instrumentation under R&D: New diagnostic reagents, diagnostic kits.

1830

MERITECH, INC.

Add: 600 Corporate Circle, Suite H Golden, Colorado 80401 Tel: (303) 790-4670 Fax: (303) 790-4859 Web site: www.meritech.com

1829

President/CEO: Don Berns

MERIDIAN MEDICAL TECHNOLOGIES, INC.

Add: 6350 Steven Forest Rd. Columbia, MD 21046 Tel: (443) 259-7800

R&D expertise: Development and manufacture of automated hand and glove washing/sanitizing systems. Technological expertise: CH/S Principal products/instrumentation: CleanTech® automated hand/glove washing systemsmodel for human diseases.

Fax: (443) 259-7801 E-mail: [email protected]

Main products/instrumentation under R&D: Self-clean cycle devices.

Web site: www.meridianmeds.com President/CEO: James H. Miller Research director: Tom Handel R&D expertise: Development and manufacture of medical device for serving emergency and home healthcare equipment. Key sales market contracts: Dey Labs.

Sealed and granted patents: Cylinders, selfclean cycles; others pending.

1831

MESSAGE PHARMACEUTICALS, INC.

Key license and trade contracts: Mylan Labs, Genpharm.

Add: 30 Spring Mill Dr. Malvern, PA 19355

Technological expertise: DD, D-D

Tel: (610) 695-0600 ®

Principal products/instrumentation: EpiPen , EpiEZPen®, Truject®, CardioBeeper® CB IIa heart monitor, CardioBeeper 12L cardiac monitor, CardioBeeper® 601A, Cartrix 2000 with WhisperPoint® needle, AtroPen®, comboPen®, Mark I, Morphine® Injector, Diazepam Injector, Binaject®; home healthcare equipment. Main products/instrumentation under R&D: Emergency medical devices, home healthcare equipment, autoinjectors. Subsidiary bodies: St. Louis, MO. Sealed and granted patents: Over 176 patents approved and pending for autoinjectors and injection technology.

Fax: (610) 695-0957 President/CEO: Robert Taber, Ph.D. Research director: Tony Giordano, Ph.D. R&D expertise: Biotechnology development and products manufacture of small molecules which modulate protein/RNA interactions. Key license and trade contracts: University of California. Technological expertise: SMC, C/TC, COC, D-D, GA, HTDS, P/S, RD Principal products/instrumentation: Small molecular drugs, modulator.

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1832

EVOGENE LTD.

Add: P.O. Box 2100 13 Gad Feinstein St. Rehovot 76121, Israel Tel: (972) 8-931-1900

567

of fatty acid metabolism in plants, 6,586,658, U.S.; methods for producing poly(hydroxy) fatty acids in bacteria, 6,770,464, U.S. (2002 ~ 2008).

1834

METAMORPHIX, INC.

Fax: (972) 8-946-6724 E-mail: [email protected] Web site: www.evogene.com President/CEO: Zeev Bronfeld Research director: Dr. Yoseph Shaalfiel R&D expertise: R&D/manufacture of plant tissue culture bioreactors. Technological expertise: RD, C/TC Main products/instrumentation under R&D: Inexpressive proprietary bioreactors for its proprietion of plant tissue cultures for secondary metabolite extraction pilot plant stage, 3000liter facility; plant tissue culture bioreactors.

1833

METABOLIX, INC.

Add: 21 Erie St. Cambridge, MA 02139 Tel: (617) 583-1700 Fax: (617) 583-1768 Web site: www.metabolix.com President/CEO: Edward Muller

Add: Center Park II., Suite 320 4061 Powdermill Road Calverton, MD 20705 Tel: (301) 617-9080 Fax: (301) 617-9075 Web site: www.mmigenomics.com President/CEO: Edwin C. Quattlebaum, Ph.D. Research director: Linda Yaswen-Corkey, Ph.D. R&D expertise: Development and manufacture of GDFs as an effective approach for improving livestock production efficiency and novel products for enhancing animal health. R&D collaboration: Texas A&M, Avigenics, USDA, American Home Products (Corporate Partnership). Technological expertise: Q, T, AB, C/TC, P/S, RD Main products/instrumentation under R&D: Agricultural biotechnology products, GDFs, animal health novel products.

Research director: Oliver Peoples R&D expertise: Development, production and applications of biodegradable polymers using transgenic technologies. Technological expertise: F, BP Principal products/instrumentation: Biodegradable polymers, contract R&D products, transgenic technologies. Sealed and granted patents: U.S. Patent Nos: 5,229,279; 5,245,023; 5,250,430; 5,480,794; 5,512,669; 5,534,432; 5,625,030; 5,661,026; 5,663,063; 5,798,235; 5,811,272; EP0870837A1; Multi-gene expression constructs containing modified inteins. 7,026,526, U.S.; modification

1835

METHYLGENE, INC.

Add: 7220 Frederick-BantingMontreal, Quebec H4S 2A1 Canada Tel: (514) 337-3333 E-mail: [email protected] Web site: www.methylgene.com President: Donald F. Corcoran Research director: Dr. Jeffrey Besterman R&D expertise: Application of antisense, oligonucleotides and small molecule chemistries to develop therapeutics of cancer and other

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diseases with initial focus on development of inhibitors of DNA methyltransferase for cancers, small molecule beta-lactamase inhibitors and of several antibodies.

Tel: (650) 903-9100

R&D collaboration: Hybridon, McGill University, University of Montreal, Northwestern Medical School, Montreal General Hospital.

R&D expertise: Development, manufacture and commercialization of new biomedical products for detection and management of human bone and joint diseases.

Technological expertise: AS, C-TC, E, GT, SMC, SY, COC, GA, HTDS, S Main products/instrumentation under R&D: DNA MeTase antisense inhibitors, DNA MeTase mechanistic-based inhibitors, DNA MeTase inhibitors, Combinatorial Chemistry Medicinal Chemistry Program, beta-lactamase inhibitors; Phase II of MGLD 265, administered orally for 21 days, in combination with either oral daily anti-cancer agents Tarceva or docetaxel intravenously once every three weeks, for the treatment of advanced metastatic malignancies, 2009. Sealed and granted patents: 32 patents and applications. 1836

METKINEN, OY.

Add: Liekokatu 2, SF- 21620, Kuusisto, Finland Tel: (358) 40-543-3740 Fax: (358) 40-246-2952 E-mail: [email protected] Web site: www.metkinen.fi President/CEO: Alex Midline R&D expertise: Biotechnology drug products development/manufacture. Technological expertise: F, P/S Principal products/instrumentation: Microbial (fungal, actinomycetes or bacteria) strainsproducts (statins), strains products of other substances, industrial production technology of fermentation, recovery and purification.

President/CEO: George W. Dunbar Research director: Gerald Allen, Ph.D.

R&D collaboration: Abbott Laboratories, Bayer Corp., BioQuant, INC. Celtrix Pharmaceuticals, Cholestech Corp., NovaDx, Rowett Research Institute, Sumitomo Pharmaceuticals Co., Ltd., Pacific Biometrics, Beckman Coulter. Key sales market contracts: Berlex Laboratories. Key license and trade contracts: Sumitomo Pharmaceuticals, DPC, Ciba-Geigy, Chiron, Diagnostic Products, Bayer, Haematologic Technologies. Technological expertise: PA, SMC, C/TC, H/CF, PB, PMC, P/S. Principal products/instrumentation: Pyrilinks®, Pyrilinks® -D, Prolagen®-C, NovaCalcin™, Alkphase-B®, Chondrex, QUS-2™. Main products/instrumentation under R&D: New bone and cartilage markers — in development. R&D: Biochemical markers and immunoassays for bone and joint diseases, osteoporosis diagnostics/therapeutics, pediatric growth abnormalities, metastatic bone cancer, endocrine growth disorders, ultrasound scanning products for bone status. Subsidiary bodies: Oregon, Australia, Italy, United Kingdom. Sealed and granted patents: Patents for measurement of collagen crosslinks and ultrasound measurement.

1838 1837

METRA BIOSYSTEMS, INC.

Add: 265 North Whisman Road Mountain View, California 94043-3911

METRATRON, INC.

Add: 501 G St. SE Washington, DC 20003 Tel: (202) 543-0364 E-Mail: [email protected]

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President/CEO: Eric C. Fruhstrofer

Fax: (847) 680-1199

Research: Aldar S, Bourinbaiar

E-mail: [email protected]

R&D expertise: R&D of therapeutics for herpes and AIDS, related novel products manufacture.

Web site: www.mt.com/autochem.

Technological expertise: SMC, D-D

Research director: Jim Harness

Principal products/instrumentation: Herpes and AIDS drugs.

Subsidiary of Mettler Toledo.

Main products/instrumentation under R&D: Herpes vaccines, AIDS vaccines. Sealed and granted patents: 5,541,212; 5,552,382; 5,811,390; 5,837,729; 6,001,808; others pending. 1839

METTLER TOLEDO GMBH, PROCESS ANALYTICS

Add: Industries Nord Im Hackacker 15 Urdorf ZH-8902 Switzerland Tel: (41) 44-736-2211 Fax: (41) 44-736-2636

569

President/CEO: Edward G. Gordon

R&D expertise: Research and development of biomedical laboratory automation. Technological expertise: COC, CH/S, HTDS, P/S, R, SMC, SY Principal products/instrumentation: Combinatorial chemistry, automated workstations for weighing, pipetting, liquid dispensing, filtering, solid-phase extracting, labeling, microplate handling, heating/cooling, septum piercing, and decapping/capping, organic synthesis, and supporting workstations. Main products/instrumentation under R&D: Continued life sciences and chemistry sample prep, workstations.

E-mail: [email protected] President/CEO: Peter Mory R&D expertise: R&D of laboratory research measurement system, related products manufacture. Technological expertise: BME, PMC Principal products/instrumentation: pH/ Redox measurement systems; dissolved oxygen measurement systems; turbidity measurement; turbidimeter, conductivity measurement systems. Main products/instrumentation under R&D: Laboratory measurements system for scientific research. 1840

METTLER-TOLEPO BOHDON, INC.

Add: 562 E. Blinker Ct. Vernon Hills, IL 60061-1831 Tel: (847) 680-3939

1841

METUCHEN ANALYTICAL, INC.

Add: 25 Mack Dr. Edison, NJ 08817 Tel: (732) 287-8898 Fax: (732) 287-0980 E-mail: [email protected] President/CEO: J. Stephen Duerr R&D expertise: Analytical research of biochemistry, microbiology and materials science. Technological expertise: CH/S Principal products/instrumentation: Contract R&D products, specialty chemicals, biomaterials, microbial products: microbicide, microbial sensor, microbial pest control.

1842

MICROFLUIDICS INTERNATIONAL CORPORATION

Add: 30 Ossipee Rd. Newton, MA 02464

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Tel: (617) 969-5452

Tel: (908) 561-3416

Fax: (617) 965-1213

Fax: (847) 272-7893

Web site: www.microfluidicscorp.com

E-mail: [email protected]

President/CEO: Irv Gruverman

Web site: www.micra.com

Research director: Bud Higgins

President/CEO: Juan Alvarez

R&D expertise: Development and manufacture of pressurized fluid processing equipment for cell disruption, emulsions, dispersions, encapsulations, liposomes, used in laboratory, pilot and production applications.

Research director: Tim Harder

Technological expertise: BS, GT, G, C/TC, BME, PG, DD Principal products/instrumentation: Contract R&D instrumentation, pressurized fluid processing equipment, cell disruption devices, cell dispersion devices, liposomes. 1843

MICHROM BIESOURCES, INC.

Add: Michrom Bioresources, Inc.1945 Industrial DriveAuburn, CA 95603 Tel: (530) 888-6498 Fax: (530) 888-8295

R&D expertise: Manufacturing and marketing of HPLC and several supports. Technological expertise: P/S, HC, DKHC, CPHC Principal products/instrumentation: SynChropak and SynChroprep HPLC columns, several supports for all modes of HPLC; MICRA NPS (non-porous silica). Main products/instrumentation under R&D: Non-porous supports for all HPLC modes, non-porous silica supports.

1845

MICROBE INOTECH LABORATORIES, INC.

E-mail: [email protected]

Add: 7259 Lansdowne Avenue, Suite 200 St. Louis, MO 63119-3421

Web site: www.michrom.com

Tel: (314) 645-2177

President/CEO: Kerry D. Nugent

Fax: (314) 645-2544

R&D expertise: Development/manufacture of HPLC and LC/MS instruments and supplies for high sensitivity and high throughput applications.

E-mail: [email protected]

Technological expertise: P/S, PB, SMC, COC, CH/S, HTDS Principal products/instrumentation: Magic 2002 HPLC System, Michrom Magic Bullets, HPLC product and supplies; high sensitivity/ high throughput instruments. Sealed and granted patents: Michrom Magic Bullets. 1844

MICRA, INC.

Add: 735 Belvidere Ave. Plainfield, NJ 070622054

Web site: www.microbe-environmental.com President/CEO: Bruce C. Hemming, Ph.D. Research director: Barry L Haymore, Ph.D. R&D expertise: Microbiological identification and characterization laboratory research services; R&D of rapid microbial detection and quantification assays for biotechnology, food, pharmaceutical and environmental industries. R&D collaboration: United States Dept. of Agriculture, DuPont. Key sales market contracts: Qualicon (subsidiary of DuPont). Technological expertise: F, SMC, BA, COC, CH/S, RD, LP, P/S, E, bioremediation

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microbial characterization/identification, microbiology laboratory research services.

Tel: (44) 1223-830-860

Principal products/instrumentation: Proprietary microbial kinetic and endpoint assays, biodegradation and biofeasibility assays, microbial databases which contain over 6,000 species of microbes (including the most extensive E.coli 0157: H7 identification databases in the world), and specialized skills in using and integrating results from combined gas chromatography, automated molecular typing — Qualicon’s RiboPrinter, and Biolog plate reader instruments.

E-Mail: [email protected]

Main products/instrumentation under R&D: Rapid tests kits for bacteria identification and quantification, bioencapsulation technology for bacteria and viruses.

Key license and trade contracts: CIBA, Idemitsu Kosan, Gustafson, Sandoz.

Sealed and granted patents: Patents for microorganism detection, quantification and encapsulation.

1846

MICROBIAL INSIGHTS, INC.

Add: 2340 Stock Creek Blvd. Rockford, TN 37853-3044 Tel: (865) 573-8188

Fax: (44) 1223-830-861 President/CEO: G H Barker Research director: Paul Williams, Ph.D. R&D expertise: R&D/manufacture of biopesticides and biofertilizers. R&D collaboration: Agricultural and Food Research Council. Key sales market contracts: Helena Chemical, First Line Seeds.

Technological expertise: F, BA Principal products/instrumentation: Nernasys®, NemasysH® biological control agents, HiStick®, HiFlow®, HiCoat® Rhizobium inoculants. Main products/instrumentation under R&D: B. Subtilis, VAMycorrizae. Subsidiary bodies: Hemel Hempstead, Little Hampton. Sealed and granted patents: Biological slug control, biological fungicide.

Fax: (865) 573-8133 Web site: www.microbe.com President/CEO: Andrew White R&D expertise: Research and products development of analytical chemistry to characterize microorganisms through contract research, bioremediation and the clinical analysis of candidiasis. Technological expertise: SMC, PMC, P/S Main products/instrumentation under R&D: Rapid method for the detection of cryptosporidium.

1847

MICROBIO, LTD.

Add: 17 High St. Whittlesford, Cambridge CB2 2NJ U.K.

1848

MICROBIONICS, INC.

Add: 535 Middlefield Road Menlo Park, CA 94025-3459 Tel: (650) 328-0190 Fax: (650) 328-0190 President/CEO: Michael C. Viguerie Research director: Marc A. Madou R&D expertise: Manufacture/marketing of electrochemical sensor arrays for cost-effective front-end data acquisition. R&D collaboration: NASA, OSU Center for Industrial Sensors and Measurements. Technological expertise: BME, E, ET

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Principal products/instrumentation: Electrochemical sensor arrays, biosensor, contract R&D products.

1849

MICROBIX BIOSYSTEMS, INC.

Add: 265 Watline Avenue Mississauga, Ontario, L4Z 1P3 Canada Tel: (416) 234-1624

screening, cosmetics, essential oils, perfumes, rare chemicals and intermediates. Technological expertise: SMC, R, HTDS Principal products/instrumentation: Microbotanica-Amazon collection: Natural plant extracts, partitioned plant extracts, pure natural products.

1851

MICROCAL, LLC.

Fax: (416) 234-1626 E-mail: [email protected] Web site: www.microbix.com President/CEO: William J. Gastle Research director: Kevin Cassidy R&D expertise: Development and manufacture of biologicals derived from microbial and mammalian culture.

Add: 800 Centennial Avenue Piscataway, NJ 08554 Tel: (800) 526-3593 Fax: (877) 295-8102 E-mail: [email protected] Web site: www.microcalorimetry.com President/CEO: William Gelb

Key license and trade contracts: McMaster University.

R&D expertise: Manufacture and development of ultrasensitive DSC and ITC calorimeters.

Technological expertise: F, C/TC, RD, P/S, BA

Technological expertise: E, F, PA, BA, D-D, CB, COC, H/CF, CH/S

Principal products/instrumentation: Full range of antigens from viruses, parasites, and bacteria, immunodiagnostic kit, natural and recombinant biologicals, including scale-up and process development, biopharmaceutical generic drugs, adenovirus-vector based veterinary vaccines.

Principal products/instrumentation: VP ITC and DSC microcalorimeters; Auto-iTC200 microcalorimeter: a wide range of applications can be used with the Auto-iTC200 including characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids, and other biomolecules, enzyme kinetics, assessing the effects of molecular structure changes on binding mechanisms, and biotherapeutic construct selection, 2009; AutoiTC200 microcalorimeter: The Auto-Isothermal Titration Calorimetery (Auto-iTC200) combines the iTC200 with full automation to run up to 75 samples per day, 2009.

Main products/instrumentation under R&D: Dengue virus vaccine, Rabies vaccine, Thromboclear generic urokinase.

1850

MICROBOTANICA, INC.

Add: 21George Washington Plaza Gaylordsville, CT 06755

Main products/instrumentation under R&D: High throughput calorimeters.

Tel: (860) 355-5805 E-mail: [email protected]

1852

ORIGINLAB CORPORATION

President/CEO: John P. Devlin R&D expertise: Development and manufacture of extracts from higher plants in microplates for

Add: One Roundhouse Plaza Northampton, MA 01060

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Tel: (413) 586-2013

1854

Fax: (413) 585-0126

573

MICRODATA INSTRUMENTS, INC.

E-mail: [email protected] Web site: http://cerncourier.com/cws/latest/cern President/CEO: Dr. C. P. Yang Research director: Dr. C. P. Yang R&D expertise: Research and manufacture of biotechnology software. Joint ventures: Microcal, INC. Technological expertise: CH/S Principal products/instrumentation: Origin™, data acquisition system, Origin Professional, origin 6.0, a fast, powerful and ready to use data windows, 2008. Main products/instrumentation under R&D: Biotechnology software for scientific softwares.

1853

MICROCIDE, INC.

Add: 2727 Second Ave. #334 Detroit, MI48201 Tel: (248) 342-6279

Add: 1207 Hogan Dr. South Plainfield, NJ 07080 Tel: (908) 222-1717 Fax: (908) 222-1365 E-mail: [email protected] Web site: http://www.microdatamdi.com/ President/CEO: George Cai R&D expertise: Development and manufacture of microdata imstrumentation for laboratory drug research. Technological expertise: CH/S, DD, BME Principal products/instrumentation: Multichannel Microinjection; multichannel micropipettor, multichannel pipettor, multichannel analyzer, perfusion systems; singlemulti pipette pullers, multichannel date recorder.

1855

MICRODYN TECHNOLOGIES, INC.

Fax: (248) 526-9663 E-mail: [email protected] Web site: www.microcide.com President/CEO: James E. Rurka Research director: Keith Bostian R&D expertise: Manufacture and marketing of antibiotics and biologicals for human infectious diseases. R&D collaboration: Pfizer, Johnson & Johnson, Daiichi. Technological expertise: F, AF, BI, COC, HTDS, P/S, R Main products/instrumentation under R&D: Biologicals, antibiotics, preclinical. Subsidiary bodies: 320 Logue Ave.

Add: 1204 Briar Patch Lane P.O. Box 98269 Raleigh, NC 27624 Tel: (919) 872-9375 Fax: (919) 872-9375 Web site: www.microdyntech.com President/CEO: Walter R. Pupa R&D expertise: R&D of Cross flow microfiltration systems and other professional devices, related novel products manufacture. Technological expertise: C/TC, P/S, BA Principal products/instrumentation: EnkaMicrodyn® fitratopm devices, Enka-Diaperm® dialysis devices, cross-flow membrane, crossflow chromatography, cross-flow absorber devices.

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MICROFLEX CORPORATION

Add: 2301 Robb Drive Reno, NV 89523

1858

MICROGENOMICS, INC.

Tel: (775) 876-6866

Add: 11211 Sorrento Valley Rd Q San Diego, CA 92121

Fax: (775) 746-6577

Tel: (858) 457-8387

Web site: www.microflex.com President/CEO: Nathan Saks Research director: Kirk Penner R&D expertise: Development and manufacture of high-quality plant latex and synthetic hand protection. Principal products/instrumentation: Synthetic Gloves: NeoPro, Supreno; Powder-Free Gloves: Evolution One, Diamond Grip Plus, Diamond Grip, Ultra One, Synetron, SafeGrip; Lightly-Powdered Gloves: Micro One, Power Grip, Color Touch; Industrial Grade Gloves: Nitron One, Derma Care.

1857

President: Dan Tripodi, Ph.D. Research director: James Hoch, Ph.D. R&D expertise: Development and design of new technologies to clone and express novel pathways from environmental microorganisms for the production of high value chemicals and biopharmaceuticals. Joint ventures: Eastman Chemical, Genecor International, Argonne National Laboratory, Electosynthesis, INC. Technological expertise: E, Q, AF, HTDS, RD Principal products/instrumentation: Contract R&D technologies, natural products, cloned gene, clonal propagation, cloning by expression.

MICROFLOW, LTD. 1859

Add: 52 Royce Close Andover, Hants SP10 3TS U.K.

MIGENIX INC.

Tel: (44) 1264-835-835

Add: 102 — 2389 Health Sciences Mall Vancouver, BC V6T 1Z3 Canada

Fax: (44) 1264-835-836

Tel: (604) 221-9666

Web site: www.astec-microflow.co.uk

Fax: (604) 221-9688

President/CEO: N. Adams

E-mail: [email protected]

R&D expertise: Manufacture and marketing of containment and environmental contaminant control equipment.

Web site: http://www.migenix.com/ President/CEO: Dany Hadary Research director: Dr. Michael West

Technological expertise: CC, E, F, AF, PA, Q, TE, T, AB, BI, BS, CB, C/TC, COC, CH/S, DD, D-D, H/CF, PB, PMC, P/S, RD, R, SMC, SY

R&D expertise: R&D biopharmaceuticals — novel antibiotics to cure infections caused by drug resistant bacteria; related products manufacture.

Principal products/instrumentation: Microflow (trade name) biological safety cabinets, laminar flow cabinets, PCR workstations, contaminant isolation technology of drug research laboratory.

R&D collaboration: University of British Columbia; University of Victoria; Canadian Bacterial Diseases Network; British Columbia Cancer Agency. Technological expertise: RD, D-D, PIS.

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Main products/instrumentation under R&D: Novel antibiotics; Enhancins, Bactolysins — both preclinical; lipopeptides. Sealed and granted patents: Compositions and methods for treating infectious basing cationic peptides alone or in combination with antibiotics, 6,503,881, U.S.; Extractive purification of lipopeptide antibiotics. 6,716,962, U.S; Derivatives of laspartomycin and preparation and use thereof. 6,737,403, U.S.

575

President/CEO: Dr. Erich Felber Research director: Dr. Patrick Baeuerle R&D expertise: Development, design and manufacture of therapeutics for selective eradication of disease-causing cells. R&D collaboration: Target identification program (molecular analysis of micrometastic cells) with Institute for Immunology/Institute of Human Genetics, University of Munich. Key sales market contracts: Baxter, Dynal: worldwide distribution of immunoreagent kit.

1860

MICROMASS, INC.

Add: 100 Cummings Center, Suite 407 N Beverly, MA 01915-6101 Tel: (978) 524-8200 Fax: (978) 524-8210

Technological expertise: D-D, BI, C/TC Main products/instrumentation under R&D: Antibody-based drug formats, including: BITE, Biospecific T-cell engage; Fully human antibodies; heterominibodies, eradicative medicines for disease-causing cells.

E-mail: [email protected] Web site: www.micromass.co.uk President/CEO: Dr. Tim Riley Research director: Lance Nicolaysen R&D expertise: Development of instruments with a focus on mass spectrometer of pharmaceutical research and novel products manufacture. Technological expertise: Q, CH/S, BI, COC, PG, G Principal products/instrumentation: Mass Spectrometers: Q-TOF, LCT, TOFSPEC-2E, QUAT-TRO-LC; Protein Lynx mass spectrograph. Subsidiary bodies: Worldwide.

1862

MICRONICS, INC.

Add: 8463 154th Avenue NE, Building G Redmond, WA 98052 Tel: (425) 895-9197 Fax: (425) 895-1183 Web site: www.micronics.net President/CEO: Jim Merselis Research director: Tom Scaulte, Ph.D. R&D expertise: Development and manufacture of laboratory instruments on-a-chip medical diagnostics. R&D collaboration: Beckman Coulter and Honeywell.

1861

MICROMET, INC.

Add: 6707 Democracy Blvd., Suite 505 Bethesda, MD 20817 Tel: (240) 752-1420 Fax: (240) 752-1425 E-mail: [email protected] Web site: www.micromet.de

Technological expertise: G, PMC, SMC, SY, BME Main products/instrumentation under R&D: 22 Peremeter Hematology Instruments, Microfluidin Research Kit. Sealed and granted patents: 5,716,852; 5,747,349; 4,726,404; 5,726,751; 5,748,827; 592210; 6,007,775; 6,067,157; 5,974,867;

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5,932,100; 5,971,158; 5,948,684; 592710; others pending.

1863

Main products/instrumentation under R&D: Automated combinatorial chemistry, automatic titration workstation.

MICRON SEPARATIONS, INC. 1865

Add: 135 Flanders Rd. Box 1046 Westborough, MA 01581-1031

MICROSAFE B.V.

Tel: (508) 366-8212

Add: Niels Bohrweg 11-13 2333 CA Leiden The Netherlands

Fax: (508) 366-5840

Tel: (31) 71-523-1886

President/CEO: James S. Johnson, Ph.D.

Fax: (31) 71-523-5980

Research director: James S. Johnson, Ph.D.

E-mail: [email protected]

R&D expertise: Research and manufacture of life sciences industry and industrial filtration.

President/CEO: T. Jolande Schoemaker

Technological expertise: BME, BA

R&D expertise: Research of microbiological and virological in vitro quality control tests for market release, development of pharmaceutical and biotechnological products and sterile medical devices. Consultancy supporting microbiological and virological product safety.

Principal products/instrumentation: MagnaCharge, MagnaLift, PVDF-Plus, Magna, NitroPure, NitroPlus, NitroBind, Cameo, Calyx, AcetatePlus, MicroFuge, UltraFuge, Savur. Sealed and granted patents: Nylon and Acetate Patent # 5,215,662 and 4,894,157.

1864

MICROPLATE AUTOMATION, INC.

Add: 560 Fellowship Rd. Ste.211 Mt. Laurel, NJ 08054-1223

Research director: Joke Ederveen

Technological expertise: C/TC Principal products/instrumentation: Contract research/clinical trial products, in vitro toxicology testing method, pharmaceuticals, process validation, vaccines, veterinary products, biologicals, reagents, sterile medical devices, specialty chemicals, biotechnological drugs.

Tel: (856) 778-3110 Fax: (800) 781-2247 E-mail: [email protected] Web site: www.microplateautomation.com President/CEO: Paul Hensley Research director: Felix Rivera

1866

MICROSOURCE DISCOVERY SYSTEMS, INC.

Add: 11 George Washington Plaza Gaylordsville, CT 06755

R&D expertise: Manufacture and marketing of robotic fluid handling for microplates.

Tel: (860) 350-8078

Technological expertise: COC, CH/S, D-D, HTDS, R

E-mail: [email protected]

Principal products/instrumentation: AutoChem workstation; AR/M®, Easy Flow Automation, Microplate Bookcase®.

President/CEO: Mary J. Ortner, Ph.D.

Fax: (860) 354-5300 Web site: www.msdiscovery.com Research director: John P. Devlin, Ph.D.

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R&D expertise: Development and manufacture of compounds in microplates for high throughput screening.

R&D collaboration: Maff (U.K.), University of British Columbia, University of Victoria.

Technological expertise: HTDS

Key license and trade contracts: The University of Victoria, Simon Fraser University, DFO, UBC, OSU.

Principal products/instrumentation: Research compounds in microplates; Scandinavian biotechnology consulting; natural products. Main products/instrumentation under R&D: Specialty compounds in microplates.

1867

MICRO-TECH SCIENTIFIC, INC.

Add: 2330 Cousteau Court Vista, CA 92081 Tel: (760) 597-9088 President/CEO: Dr. Frank J. Yang Research director: David Park R&D expertise: Manufacture and marketing of HPLC and columns for pharmaceutical research. Technological expertise: CC, P/S, PIS, CB Principal products/instrumentation: Microbore and capillary HPLC columns, microbore column HPLC and accessories, microbore column chromatography.

Key sales market contracts: Bayer AG.

Technological expertise: PA, F, RD, P/S, GA, BA, H/CF, C/TC, DD Principal products/instrumentation: MICROVIB bi-valent vibriosis vaccine; MICROSAL furunculosis vaccine; rELISA aquaculture disease diagnostic kit; MultiVacc4, MultiVacc4, LADS-latex bead diagnostics. Main products/instrumentation under R&D: Vaccines for cultured shrimp, field trial; vaccines for bacterial kidney disease, development; vaccines for IHN, VHS, IPN, PKX, Pasturella, field trial.

1869

MICROTEST LABORATORIES, INC.

Add: 104 Gold St. Agawam, MA 01001 Tel: (413) 631-1680 Fax: (413) 789-4334

1868

MICROTEK INTERNATIONAL, LTD.

Add: 6761 Kirkpatrick Crescent, Saanichton, British Columbia V8M 1Z8 Canada Tel: (250) 652-4482 Fax: (250) 652-4802 Web site: www.microtek-intl.com President/CEO: William Kay, Ph.D. Research director: Julian Thornton, Ph.D. Subsidiary of Microtek Holdings, INC. R&D expertise: R&D/manufacture of aquaculture vaccines and diagnostics, agriculture diagnostics.

E-mail: [email protected] Web site: www.microtestlabs.com President/CEO: Steven G. Richter, Ph.D. Research director: Dennis Champagne R&D expertise: Contract laboratory R&D of biomedical devices for pharmaceutical and biotechnology industries. Technological expertise: RD, C/TC Principal products/instrumentation: Biologicals, cosmetics, detergents, diagnostics, in vitro toxicology testing method, pharmaceuticals, plastics, reagents, process validations, contract R&D products, biomedical devices for drug research.

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MIDLAND BIOPRODUCTS CORP.

Add: 800 Snedden Dr. P.O. Box 309 Boone, IA 50036

primers, adaptors, linkers), RNA and DNA polymers, custom gene synthesis, DNA sequencing, DNA cloning vector, DNA database, DNA protein complex, DNA recombinant, DNA sequencer, DNA sequence analysis.

Tel: (515) 432-7799 Fax: (515) 432-7790

1872

E-mail: [email protected]

MIDWEST BIOLOGICAL PRODUCTS, INC.

Web site: www.midlandbio.com

Add: P.O. Box 407 River Falls, WI 54022

President/CEO: Richard D. Jorgenson, Ph.D.

Tel: (715) 419-9270

Research director: Jerry McVicker, M.S.

Fax: (715) 425-0697

R&D expertise: Development and manufacture of biotechnology medicines and diagnostic products.

E-mail: [email protected]

Technological expertise: PA, PC, PPAT, P/PS Principal products/instrumentation: Contract manufacturing products, Quick test calf IGG kit, Quick test bovine colostrum, Quick yest foal IGG kit, Quick test equine colostrum, Diagnostic kits of livestock diseases. Subsidiary bodies: Protein Chemistry Lab, Scarborough, ME.

1871

MIDLAND CERTIFIED REAGENT CO.

Add: 3112-AW. CuthbertAve. Midland, TX 79701-5511 Tel: (432) 694-7950 Fax: (432) 694-2387

Web site: www.midwestbio.com President/CEO: Stephen Erickson Research director: Stephen Erickson R&D expertise: R&D/manufacture of contract protein purification; supply of autoimmune antigens CRNP/SM, SM, SSA, SSB, Sc 170. Technological expertise: E, P/S, BA, PC, P/PS Principal products/instrumentation: RNP/ Sm, Sm, Sc 1-70; Topoisomerase. Main products/instrumentation under R&D: SSB, SSA, To-1; Recombinant SSA, SSB, To-1; RNP proteins Sm proteins.

1873

MIDWEST RESEARCH INSTITUTE

E-mail: [email protected]

Add: 425 Volker Blvd. Kansas City, MO 64110-2241

Web site: www.oligos.com

Tel: (816) 753-7600

President/CEO: Richard V. Case, Ph.D.

Fax: (816) 753-8420

Research director: Richard Case, Ph.D.

Web site: www.mriresearch.org

R&D expertise: Research of synthesis and purification of DNA and RNA; molecular biology related products manufacture.

President/CEO: John McKelvey Research director: Dr. William Duncan

Technological expertise: Q, SY, G

R&D expertise: Contract research of biopharmaceuticals and other products.

Principal products/instrumentation: Synthetic DNA and RNA (custom oligonucleotides,

Technological expertise: PA, Q, CC, RD, P/S, GA, R, C/TC, HTDS, SMC, SY

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Principal products/instrumentation: Vaccines, contract research/clinical trials products, veterinary products, natural products, biopharmaceuticals, immunodetection kits.

579

Tel: (800) 640-2613 Web site: www.mieleusa.com President/CEO: Nick Ord R&D expertise: Development and manufacture of laboratory glassware cleaning systems.

1874

MIDSCI

Add: 280 Vance Road St. Louis MO 63088 Tel: (800) 227-9997

Technological expertise: BME, Q, P/PS Principal products/instrumentation: Glassware washer used by many biotech companies for cleaning of DNA sequencing plates.

Fax: (800) 610-4488 E-mail: [email protected] Web site: www.midsci.com

1876

President/CEO: Larry Degenhart R&D expertise: R&D/manufacture of biotechnology laboratory equipment, such as electrophoresis, PCR, reagents, liquid nitrogen freezers, mechanical freezers to −85o C, refrigerators, tissue culture plastic ware, electroporation, liquid handling, centrifuges, purification membranes, autoradiography, CO2, incubators, biological safety cabinets, gel boxes, and general supplies for all of the above. Key license and trade contracts: ; S&S, Amresco, Bioline, Arctic Temp, Molecular Technologies, TPP, Quality Scientific Products, Sorenson, MicroZone, Cedco, Owl Scientific, Herme, Wheaton, AlphaPete, Taylor-Wharton, Classic X-Ray, SoLow, Labnet International, Labline, Thermolyne, Bamstead, Techne, Ju-naro, UVP. Technological expertise: Q, TE, C/TC, GA, H/CF, P/S, RD Principal products/instrumentation: Tissue culture plastic ware, refrigeration; coated well plates, a techno plastic products’ cell culture treated 96 –flat-well plates, for high throughput and cell culture labs, 2007; Cell, incubator, 2007.

1875

MIELE, INC

Add: 9 Independence Way Princeton, NJ 08540

MIGAL-GALILEE TECHNOLOGY CENTER

Add: Southern Industrial Zone, P.O. Box 831 Kiryat-Shmona 11016 Israel Tel: (972) 4-695-3511 Fax: (972) 4-694-4980 E-mail: [email protected] Web site: www.migal.org.il President/CEO: Jacob Arzi Research director: Jacob Arzi R&D expertise: R&D of human biotechnology, agriculture and environmental biotechnology, therapeutics, diagnostics, etc; related novel products manufacture. Technological expertise: E, F, PA, Q, T, D-D, AF, BA, GA, GT, P/S, RD, C/TC Principal products/instrumentation: Diagnostics, environmental detector, natural products, vaccines pesticides, agriculture, bioremediation, biosensors, nutraceuticals, pharmaceuticals, other contract R&D products, reagents.

1877

MILES, INC. DIAGNOSTICS DIVISION

Add: 195 W. Birch St. Kankakee, IL 60901 Tel: (815) 937-8270 Fax: (815) 937-8285

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Research director: Joseph G. Montalto

Tel: (617) 679-7000

R&D expertise: Development and manufacture of biologicals.

Fax: (617) 374-9379

Technological expertise: E, P/S, BA, PMC, GM

Web site: www.mlnm.com

Principal products/instrumentation: insulin, EX-CYTE® growth enhancement media supplement, Trasylol, Ciprofloxacin, Albumins, transferrins, aprotinin, fetuin, cholesterols, EXCyTE® media supplements, ciprofloxacin, trasylol® VLE, custom manufacturing products.

President/CEO: Mark Levin

1878

MILLENNIUM DIAGNOSTICS, LTD.

Add: Ganesh House, Marol Naka, Andheri (e) Mumbai, Maharashtra 400059 India Tel: (91) 22-859-3252 Fax: (91) 22-850-4412 E-mail: [email protected] Web site: www.ganeshgroup.com President/CEO: Pascoal Cervalho Research director: Pascoal Cervalho Subsidiary of Ganesh Group of Industries. R&D expertise: R&D/manufacture of healthcare and diagnostics. Technological expertise: E, F, AF, BA, C/TC, H/CF, SY, P/S Principal products/instrumentation: Bovine serum albumin, TMB substrate, media, biological, microwell ELISA for Bag, HIV, blood grouping sera, biochemistry reagents and diagnostics. Main products/instrumentation under R&D: Elisa test for hepatitis C, preclinical; healthcare medicines, diagnostic enzymes, diagnostic test kits, health protection agents.

1879

MILLENNIUM PHARMACEUTICALS, INC.

Add: 40 Landsdowne Street, Cambridge, MA 02139

E-mail: [email protected]

Research director: Frank Lee, Ph.D. R&D expertise: Commercial application research/manufacture of genetics, genomics and bioinformatics to develop novel therapeutics and diagnostic products. Joint ventures: Hofffmann-LaRoche, Eli Lilly, Astra, Wyeth-Ayerst, and Bayer. R&D collaboration: Hoffmann-La Roche, discover novel therapeutics for obesity and type II diabetes. Technological expertise: Q, T, BI, C/TC, CH/S, R, PG, RD Principal products/instrumentation: Velcade (Bortezomib) for the treatment of multiple myeloma patients who have rectived at least two prior therapies and have demonstrated disease progression on the last therapy, 2003. Main products/instrumentation under R&D: R&D stage programs in obesity, Type II diabetes, amerosderosis, asthma, cancer, CNS disease; alemtuzumab, CLL, Phase I, 2008; Campath® alemtuzumab treatment of chronic lymphocytic leukemia, Phase IV, and for treatment of multiple sclerosis, Phase II/III, 2008; LDP-519, small molecule products, for cerebral apoplexy, Phase I/II. Sealed and granted patents: Nucleic acid sequences encoding melanoma associated antigen molecules, ATPase molecules, actytransferase molecules, pyridoxal-phosphate dependent enzyme molecules and of use thereof. 7,078,205, U.S.; Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefore. 7,053,202, U.S.; Human kickoffrelated protein and nucleic acid molecules and uses thereof. 7,057,017, U.S.; 2150, human protein kinase family member and uses therefore.

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6,911,317, U.S.; Compositions and methods for the treatment and diagnosis of cardiovascular disease. 6,492,126, U.S.; Anti-CCR4 antibodies and methods of use therefore. 6,488,930, U.S.; Method of inhibiting cell function associated with CCR2 by anti-CCR2 amino-terminal domain antibodies. 6,448,021, U.S.; Compositions and methods for the treatment and diagnosis of immune disorders. 6,455,685, U.S.; Anti-CCR2 antibodies and methods of use therefore. 6,451,522, U.S.; 25,934, a novel fatty acid desaturase and uses therefore, 6,686,185, U.S.; Antibodies and ligands for “Bonzo” chemokine receptor, 7,038,018, U.S.; Tango 243 polypeptides and uses thereof, 7,083,793, U.S.; Molecules of the card-related protein family and uses thereof. 7,083,944, U.S.; FAIL molecules and uses thereof. 7,109,319, U.S.; Angiotensin converting enzyme homolog and uses therefore. 6,884,771, U.S.; 21612, novel human dehydrogenases. 7,094,565, U.S.; Genes, compositions, kits and methods for identification, assessment, prevention, and therapy of cervical cancer. 7,125,663, U.S.; Humanized anti-CCR2 antibodies and methods of use therefore. 6,696,550, U.S.; Molecules of the card-related protein family and uses thereof. 6,942,984, U.S.; Methods of inhibiting GPR-96 function. 6,936,248, U.S.; Resistance sequences and uses thereof. 6,933,105, U.S.; 25501, a human transferase family member and uses therefore. 6,929,938, U.S.; Multidrug resistance-associated polypeptide. 6,890,713, U.S.; Card related protein and uses thereof. 6,869,775, U.S.; Proteins and nucleic acids encoding same. 6,989,232, U.S.; Methods of identifying inhibitors of fatty acid transport proteins. 7,033,772, U.S.; Molecules of the NBS/LRR protein family and uses thereof. 7,034,135, U.S.; Methods and composition for the diagnosis and treatment of body weight disorders, including obesity, 6,713,277, U.S.; other patents pending. Main products/instrumentation under R&D: Filter, separation devices.

1880

581

MILLIPORE CORP.

Add: 290 Concord Rd, Billerica MA 01821 Tel: (978) 715-4321 E-mail: [email protected] Web site: www.millipore.com President/CEO: Bill Zadel R&D expertise: R&D/manufacture of filtration/ separation technology and related products. Technological expertise: P/S, BME, SI Principal products/instrumentation: Viresolve/180 membrane, Durapore® membrane device for purification, membrane devices, membrane systems, validation services and instrumentation; Kinase Profiling, 2007; Water Purification, 2007; Disposable Mixer, 2007; Labeled secondary antibodies, 2007; The new moli-Q integral water purification system, 2007; HEScGRO Stem Cell Media, 2007; Novaseal ™ crimping solution, 2007; SpectraMax® L, a microplate lumonometer for flash and glow luminescence assays, 2007; PureFlex, a multiplayer, single-use process container film with clarity and robustness, 2007; Gene expression suppressor, 2007.

1881

MIL-RAM TECHNOLOGY, INC.

Add: 4135 Business Center Drive Fremont, CA 94538 Tel: (510) 656-2001 Fax: (510) 464-2004 President/CEO: Carlos B. Ramirez R&D expertise: Research of gas detection instrumentation, related products manufacture. Technological expertise: PMC Principal products/instrumentation: Gas detection instruments, including Controller DU/sensors for gas monitoring, Tox-Array

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2000; D. DAS 1536 — Data Acquisition System, D. DAS 1536; Transmitters — detect gases, many different gases.

R&D collaboration: Chiron.

Sealed and granted patents: Patents held on all gas sensors.

Principal products/instrumentation: SynPhase™; TranStems™; custom peptides; PepSets™ (low cost sets of unpurified peptides); polyclonal antipeptide antisera; Multipin Synthesis Kits; PinAID™; synPhase™ Lanterns; SynPhase™ Workstations; TranSort™ (synthesis management system).

1882

MILTENYI BIOTEC GMBH

Add: Friedrich-Ebert- Str. 68 Bergisch Gladbach 51429 Germany

Technological expertise: CS, DOS, COC, CH/S, PIS, PA, SMC, SY

E-mail: [email protected]

Main products/instrumentation under R&D: Peptidomimetics, peptide synthesizer, solid phase synthesis system, solid phase extraction technique.

Web site: www.MiltenyiBiotec.com

Subsidiary bodies: U.S.A.; France; U.K.

Tel: (49) 2204-8306-0 Fax: (49) 2204-85197

President/CEO: Stefan Miltenyi Research director: Dr. Jurgen Schmitz R&D expertise: Development and manufacture of magnetic cell separation systems and several reagents. Technological expertise: P/S, H/CF, C/TC, CH/S

1884

MINRAY-BIOLOGICAL DIVISION

Add: Havat Halimud P.O. Box 29229 Jerusalem 91291 Israel Tel: (972) 2-673-3212

Principal products/instrumentation: MACS, magnetic cell separation systems and reagents.

Fax: (972) 2-673-3265

Main products/instrumentation under R&D: Biology reagents, diagnostic test kits.

President/CEO: Gabriel Kenan

1883

MIMOTOPES PTY, LTD.

Add: 11 Duerdin St. Clayton, Victoria 3168 Australia Tel: (613) 9565-1111 Fax: (613) 9565-1199 E-mail: [email protected] Web site: www.mimotopes.com President/CEO: Ron Deane Research director: Dr. Andrew Bray Subsidiary of Mitokor, INC. R&D expertise: Several peptides and peptide instrumentation, Solid phase synthesis providing of products and services.

E-mail: [email protected] Research director: Mordechai Keren-Zur, Ph.D. R&D expertise: Comprehensive development, design and manufacturing of biological pesticides to provide “green” and environmental friendly solution for agricultural problems. R&D collaboration: Institute of Plant Protection of Agricultural Research Organization (ARO) of Israel (Bet-Dagan). Technological expertise: F, AF, CH/S, FL Principal products/instrumentation: Bionematoicide — the product based on natural bacteria and supplemented with non-toxic additives, for control of root-knot, wheat cyst and other parasitic nematodes, “Bionem”. Main products/instrumentation under R&D: Biofungicide for control of different fungal

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diseases in various crops, field trials; tissue culture, commercial product; biological pesticides. Subsidiary bodies: Fermentation and formulation facilities, including pilot plant. Research laboratories. Base for a wide range of green house experiments.

1885

MIRA DIAGNOSTICA GMBH

Add: Hemmelrather Weg 201 Leverkusen D51377 Germany Tel: (49) 214-876-2410 Fax: (49) 214-876-2422 E-mail: [email protected] Web site: www.mira-diagnostica.de President/CEO: Dr. R.-M. Leiser Research director: Dr. L. Plobner R&D expertise: Research of microbiological monitoring, DNA analytic, separation technology, related novel products manufacture. Technological expertise: GA, P/S, H/CF Principal products/instrumentation: Test kits and contract R&D products, DNA separation and purification techniques, microbiological monitor.

583

Research director: Jon Wolff, Ph.D. R&D expertise: Development and manufacturing of in vivo, non-viral gene transfer products for use in gene therapy treatment. Key sales market contracts: Pan Vera Corp. Technological expertise: COC, DD, GT, COC Principal products/instrumentation: TransIT transfection reagents, Lab-IT DNA labeling reagents, Trans-IT In-Vivo(IV), in vivo gene delivery, gene transfer vector. Main products/instrumentation under R&D: Products are used to deliver and express foreign genes in human body, currently products that duplicate with viruses for size are available, have high and long-term expression rates, in vivo, non-viral gene transfer vector for gene therapy. Sealed and granted patents: Drug delivery, DNA transfer, template polymerization, marked DNA delivery, gene expression. Single-step method for labeling nucleic acids with mustard or aziridine labeling reagents, 6,262,252, U.S.; other patents pending.

1887

MISONIX, INC.

Main products/instrumentation under R&D: High throughput nucleic acid purification, DNA separation/analytic technologies.

Add: 1938 New Highway Farmingdale, NY 11735

Sealed and granted patents: 5 patents in the field of DNA purification and analytic.

Fax: (631) 694-9412

Tel: (631) 694-9555 Web site: www.misonix.com President/CEO: Joe Librizzi, Ph.D.

1886

MIRUS BIO LLC

Add: 545 Science Dr., Suite A Madison, WI 53711 Tel: (608) 441-2852 Fax: (608) 441-2849 E-mail: [email protected] Web site: www.mirusbio.com

Research director: Ronald Manna R&D expertise: R&D/manufacture of ultrasonic instrumentation for bioanalytical and clinical applications; Ductless fume enclosures; Downflow benches and laminar flow hoods. Key sales market contracts: U.S. Surgical; Lysonix.

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Key license and trade contracts: U.S. Surgical; Lysonix.

1889

MITOSCAN CORPORATION

Principal products/instrumentation: Ductless fume enclosures, Fume extractors, Sonicators, Ultrasonic cleaners, air pollution control equipment, laminar flow hoods, down-flow fume hoods, PCR Prep Stations, Ultrasonic rebuilders, downflow fixed bed, laminar flow burner.

Add: The Faraday Center 2800 S. Fish Hatchery Rd. Madison, WI 53711

Main products/instrumentation under R&D: Ultrasonic instruments for bioanalytical/clinical applications, downflow benches.

Web site: www.mitoscan.com

1888

MITOKOR

Tel: (608) 276-9820 Fax: (608) 273-6989 E-mail: [email protected] President/CEO: Allen J. Dines Research director: Karl Gustavson R&D expertise: R&D of biosensors and in vitro toxicology testing method, products manufacture.

Add: 11494 Sorrento Valley Rd. San Diego, CA 92121

R&D collaboration: University of Wisconsin, bioassays.

Tel: (858) 793-7800

Key license and trade contracts: Wisconsin Alumni Research Foundation.

Fax: (858) 793-7805 Web site: www.mitokor.com President: Robert E. Davis, Ph.D. Research director: Gonul Velicelebi, Ph.D. R&D expertise: Mitochondrial medicines focused on the development and manufacture of therapeutics and diagnostics for late onset degenerative diseases. R&D collaboration: Pfizer — discovery and development of mitochondrial targets and drugs for neurodegenerative diseases.

Technological expertise: E, BME Principal products/instrumentation: Mitoscan Toxicity test kits. Main products/instrumentation under R&D: Bioassays for rapid low-cost prescreening of environmental pollutants, biosensors, in vitro toxicology testing instruments.

1890

MITOTIX, INC.

Key license and trade contracts: SRL-license for use of mitoload test in Japan for diagnostic and pharmacogenetic use.

Add: 1 Kendall Square Building, Suite 622 Cambridge, MA 02139

Technological expertise: BI, C/TC, D-D, GA, HTDS, PG, Q, T, SMC

Fax: (617) 225-0005

Principal products/instrumentation: Therapeutics of late onset degenerative diseases, mitochondrial targets, mitochondrial RNA processing enzymes, mitochondrion, mitochondrial transport. Main products/instrumentation under R&D: Diagnostic and therapeutic drugs for late onset degenerative diseases.

Tel: (617) 225-0001 E-mail: [email protected] Web site: www.mitotix.com President/CEO: Jim Melanson Research director: Muz Mansuri, Ph.D. R&D expertise: R&D/manufacture of biotechnological therapentical drugs for cancer, opportunistic fungal infections and other cell proliferation disorders.

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R&D collaboration: DuPont Pharmaceuticals, BASF Pharma, Cell Genesys.

Tel: (450) 461-6245

Key license and trade contracts: Cold Spring Harbor Lab, Fred Hutchinson Cancer Research Center, Mass. General Hospital. Genetica, INC.

E-mail: [email protected]

Technological expertise: F, AF, COC, D-D, GT, HTDS, PIS, P/S, RD, R, SMC, SY

President/CEO: John Finney

Main products/instrumentation under R&D: CDK Inhibitors for cancer, preclinical; CDC25 Inhibitors for cancer, preclinical; pl6 and p27 gene therapy for restenosis, cancer, preclinical; cell wall integrity inhibitors for fungal infections, preclinical, biotechnology medicines for cancers and other diseases. Sealed and granted patents: 10 issued patents on cell cycle technologies, over 80 patent applications.

1891

MITR PHOL SUGAR CORP., LTD.

Add: 3rd Floor Ploenchit Center Building 2, Sukhumvit Road, Klongtoey, Bangkok 10110 Thailand Tel: (66) 0-2656-8488 Fax: (66) 0-2656-8494

585

Fax: (450) 461-6246 Web site: www.mj-research.com R&D expertise: Manufacture or contract R&D of laboratory professional equipment for biomedical research applications, including Peltier thermal cyclers. Technological expertise: Q, T, RD, GA, C/TC, AB, GT Principal products/instrumentation: PTC100™, PTC-150 Minicycler™, PTC-200 DNA Engine, PTC-225 DNA Engine Tetrad™, PTC100HB™, PTC-100-1 6ms™, Twin Tower™. Main products/instrumentation under R&D: Peltier thermal cyclers, laboratory professional equipment for medicinal research. Subsidiary bodies: 384 Oyster Point Blvd., #8, South San Francisco, CA 94080.

1893

MJS BIOLYNX, INC

E-mail: [email protected]

Add: P.O Bag 1150 300 Laurier Blvd. Brockville, ON K6V 5W1 Canada

Web site: www.mitrphol.com

Tel: (613) 498-2126

President/CEO: Mr. Isara Vongsukolkit

Fax: (613) 342-1341

R&D expertise: Cane, sugar and byproducts research; related products manufacture.

E-mail: [email protected]

Technological expertise: F, T, BI, CB, C/TC Principal products/instrumentation: Sugar, starch sugar, muscle sugar. Main products/instrumentation under R&D: Fermented product, tissue culture, sugaring, producing sugar-byproducts.

1892

MJ RESEARCH, INC.

Add: 1815 Edgewood Street St. Bruno Quebec J3V 4P1 Canada

Web site: www.biolynx.ca President/CEO: Cherin McKend R&D expertise: Research, manufacture and supply of immunotechnology, protein chemistry and molecular biology products. Key sales market contracts: Exclusive Canadian distributor of Pierce-Endogen, Seikagaku America, Matreya, INC. and Heathrow Scientific. Also, Canadian distributor of PeproTech, Simport Plastics Ltd, CHIMERX, Research Organics, Greiner America, INC. SCIE-PLAS, and Scientific Device Laboratory.

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Technological expertise: O, C, W, E, GN, HI, PA, P

President/CEO: Dr. Erik Hoppe

Principal products/instrumentation: Agriculture products, biologicals, contract manufacturing products, detergents, diagnostics, nutraceuticals, biopharmaceuticals, reagents, protein, specialty chemicals.

R&D expertise: Manufacturing/development of science research products for biotechnology medicines research.

Main products/instrumentation under R&D: Molecular biology reagent, protein chemical synthesis.

Principal products/instrumentation: Molecular biology and cell biology products, antibodies and enzymes: RNA helicase, RNA methylase, RNA polymerase, immobilized enzymes, DNA vector systems, genomic libraries, laboratory columns, Phagemid Display, Two and One Hybrid Technology, spin columns, affinity chromatography and laboratory supplies.

1894

MO BIO LABORATORIES, INC.

Add: 2746 Loker Avenue West Carlsbad, CA 92010 Tel: (760) 929-9911 Fax: (760) 929-0109 E-mail: [email protected] Web site: www.mobio.com

Research director: Dr. Jurgen Becker

Technological expertise: E, PA, C/TC, RD, P/S, D-D, GA, G, AB

Main products/instrumentation under R&D: Research reagents for biotechnology medicines. Subsidiary bodies: Mobitec LLC, Florida, U.S.A.

President: Mark N. Brolaski R&D expertise: Contract testing laboratory research and molecular biology product development/manufacture. Technological expertise: F, P/S, RD, GA Principal products/instrumentation: DNA, RNA purification kits, RNase and DNase detection kits, bacterial growth media; DNA purification from soil, DNA transcript, DNA sequencer, DNA amplification kits. Main products/instrumentation under R&D: Molecular biology reagents, DNA synthesizer.

1895

MOBITEC GMBH

1896

MODCOL CORP.

Add: 845 Stewart Dr. Ste. C Sunnyvale, CA 94085-4504 Tel: (408) 530-0010 Fax: (408) 530-0011 President/CEO: Yehuda Shalon Research director: Ted Shalon R&D expertise: Analytical research to preparative empty and slurry-packed HPLC MODcol columns and large-scale liquid chromatography MODcol columns; related novel products manufacture. Technological expertise: BME, HC, DKHC

Add: Lotzestrasse 22a Goettingen D-37083 Germany Tel: (49) 551-707-2210 Fax: (49) 551-707-2222 E-mail: [email protected] Web site: www.mobitec.de

Principal products/instrumentation: Modular columns and adaptors to analytical and preparative HPLC columns for chemical and biomolecular separations, empty columns and columns packed with premium commercial and custom media giving analytical results, pilot plant and industrial scale LC columns.

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Main products/instrumentation under R&D: Large-scale liquid chromatography MODcol columns.

587

R&D expertise: Biotechnology medicine software research; Protein function determination; Bioinformatics for drug discovery. R&D collaboration: Affymetrix Corp. Technological expertise: Q, BI, D-D, G

1897

MODULATION OPTICS, INC.

Add: 40 Garvies Point Rd. Glen Cove NY 11542 Tel: (516) 609-0000 Fax: (516) 609-0093 E-mail: [email protected] Web site: www.modulationoptics.com

Principal products/instrumentation: Stingray™ Expression Analysis Software, GeneMine™ Software, Look™ Software. Main products/instrumentation under R&D: Panther, biotechnology medicine software, bioinformatics drug discovery, protein function detecmination software, molecular modeling software for drug design.

President/CEO: Donald Brown Research director: Dr. Robert Hoffman R&D expertise: Manufacture and marketing of accessories for microscopes. Technological expertise: BME Key sales market contracts: Olympus Corp., Tokyo, Japan. Key license and trade contracts: Nikon, INC. Tokyo, Japan. Principal products/instrumentation: Hoffman Modulation Contrast System (HMC), Modulation Contrast. Main products/instrumentation under R&D: Microscope condenser, modulator, modulator promoter element.

1898

MOLECULAR APPLICATIONS GROUP

1899

MOLECULAR ARTS CORP.

Add: 1532 E Katella Ave. Ste. 100 Anaheim, CA 92805 Tel: (714) 634-8100 Fax: (714) 634-1999 President/CEO: Jeff Marusin R&D expertise: Scientific software of biotechnological drug R&D. Technological expertise: CH/S, BTS, C/TC Principal products/instrumentation: Molecules 3D & 3D Pro, Chern Clip Art 1000, Safety Clip Art 2000, Molecules-CD. Main products/instrumentation under R&D: Scientific software for biotech medicine R&D.

1900

MOLECULAR BIOLOGY INSIGHTS, INC.

Add: 607 Hansen Ave., Bldg. One P.O. Box 51110 Palo Alto, CA 94303-1110

Add: 8685 U.S. Highway 24, Cascade, CO 80809,

Tel: (650) 846-3570

Tel: (719) 684-7988

Fax: (650) 846-3497

Fax: (719) 684-7989

Web site: www.mag.com.

E-mail: [email protected]

President/CEO: Debra Yu, M.D.

Web site: www.oligo.net

Research director: Paul Thomas, Ph.D.

President/CEO: Wojciech Rychlik, Ph.D.

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R&D expertise: R&D/manufacture of Oligo Primer Analysis software; primer design, biotechnology software.

1902

MOLECULAR BIOPRODUCTS, INC.

Key sales market contracts: MedProbe A.S. ([email protected]) European distributor.

Add: 9389 Waples Street San Diego, CA 92121-3903

Technological expertise: BI, CH/S, BTS

Fax: (858) 453-4367

Principal products/instrumentation: Oligo Primer Analysis Software, DNAsis, Mac DNAsis Software.

E-mail: [email protected]

Main products/instrumentation under R&D: Biotechnology software for pharmaceutical research.

Tel: (858) 453-7551

Web site: www.mbpinc.com President/CEO: Larry Scaramella R&D expertise: R&D/manufacture of biomedical laboratory supplies. Technological expertise: RD, P/S, G, BME

1901

MOLECULAR BIOLOGY RESOURCES, INC. (MBR)

Add: 25 Marsh Court Madison, Wisconsin 53718 Tel: (414) 535-9506 E-mail: [email protected] Web site: www.chimerx.com President/CEO: Peter Smyczek Research director: Peter Smyczek R&D expertise: R&D/manufacture of enzymes, biochemicals, oligonucleotides and kits for molecular biology research. Technological expertise: Q, E, AB, RD, P/S, BA, C/TC, SY Principal products/instrumentation: Restriction endonuclease, restriction enzyme, modifying enzymes, enzyme conjugates, enzyme inhibitor complex. Main products/instrumentation under R&D: Oligonucleotides, test kits for molecular biology research. Subsidiary bodies: Chimerx Div, 3802 Packers Ave., Madison, WI 53704.

Principal products/instrumentation: Solvent Safe™, Carbon filter tip for volatile solvents, RNase Away®, removes RNase and “unwanted” DNA contaminants, PCR Rxn with wax already prepositioned for rxn; ART® Self-Sealing barrier tips; BioRobotix™ pipet tips for automated workstations; EasyStart, PCR Mix-In-A-Tube; SoftFit, SoftFit MultiChannel pipet tips; MBP tips, pure tips; PCR tubes w/PUREPAK™ packaging. Sealed and granted patents: ART® Filter pipet tips, Hot Start tubes.

1903

MOLECULAR BIOSCIENCES, INC.

Add: 4699 Nautilus Court Boulder, Colorado 80301 Tel: (303) 581-7722 Fax: (303) 581-0575 E-mail: [email protected] Web site: www.molbio.com President/CEO: David Kachensky, Ph.D. R&D expertise: R&D/manufacture of biochemicals.

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Technological expertise: CB, CH/S, P/S, SMC, SY Principal products/instrumentation: Crosslinking Reagents, Biolink™; Biotin Dimer, Avilink™; water soluble biotins, specialty chemical.

1905

589

MOLECULAR DYNAMICS INC.

Add: 928 East Arques Ave. Sunnyvale, CA 94086-4520 Tel: (408) 773-1222 Fax: (408) 773-1493 E-mail: info@[email protected]

1904

MOLECULAR DEVICES CORPORATION

President/CEO: Jay Flatley Research director: David Barker, Ph.D.

Add: 1311 Orleans Dr. Sunnyvale, CA 940891136 Tel: (800) 635-5577 Fax: (408) 747-3601

Technological expertise: Q, AB, GA, P/S, RD

E-mail: [email protected] Web site: www.moleculardevices.com President/CEO: Joe Keegan R&D expertise: BioTech, devices.

R&D expertise: Development, manufacture and marketing of instrumentation, software and reagents for life science research and drug discovery.

R&D/manufacture

of

Joint ventures: Nihon Molecular Devices with JCR Pharma. Technological expertise: G, HTDS, BME Principal products/instrumentation: FLIPR; CLIPR; Spectramax Gemini XS; Spectrarnax Plus 384®, molecular genetics research devices. Main products/instrumentation under R&D: Novel professional Bio Tech devices. Subsidiary bodies: Molecular Devices GmbH, Gutenberg Str. 10, 85737 Ismaning, Germany, Tel: (49) 898-545-050, Fax: (49) 898-542-238; Molecular Devices Ltd., Unit #6 Raleigh Court, Rutherford Way, Crawley, West Sussex, RH10 2PD, Tel: (44) 1293-619-759, Fax: (44) 1293-619-586; Nihon Molecular Devices Co., Ltd., 2-4 Kasuga-Cho, Ashiya 659, Japan; Tel: (81) 797-322-677, Fax: (81) 797-381-597. Sealed and granted patents: Molecular devices issued over 29 United States patents covering its technologies and over 46 foreign patents.

Principal products/instrumentation: ImageQuant Software; Phospherlmager System; Personal Densitometer; Fluorlmager; Storm System; BioLirmin micro assay reader, Xperiment Software, ImageSpace Software. Subsidiary bodies: Victoria, Australia; Evry Cedex, France; Krefeld, Germany; Tokyo, Japan; Kent, Ue.K. Sealed and grand patents: Methods and apparatus for template capture and normalization for submicroliter reaction, 6,489,112, U.S.; Nucleosides comprising polydentate ligands, 6,444,423, U.S. (2001 ~ 2008); other patents pending.

1906

MOLECULAR GERIATRICS CORP.

Add: 50 Lakeview Pkwy, Ste. 111 Vernon Hills, IL 60061 Tel: (847) 573-8000 Fax: (847) 573-8030 President/CEO: John DeBemardis Research director: John DeBemardis R&D expertise: R&D/manufacture of therapeutical drugs for neurodegenerative diseases. Joint ventures: Gene Logic.

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Key license and trade contracts: Albert Einstein College of Medicine. Technological expertise: PA, C/TC, H/CF, SMC, SY Main products/instrumentation under R&D: Diagnostic assay for Alzheimer’s disease, preclinical; Compounds for the treatment of Alzheimer’s disease, preclinical; treatment drugs for neurodegenerative diseases.

1907

MOLECULAR HISTOLOGY, INC.

R&D expertise: R&D and manufacturing of AFM (atomic force) and STM (scanning, tunneling) microscopes and accessories. Technological expertise: D-D, DD Principal products/instrumentation: PICO SPM Scanning Probe Microscope, MAC Mode AFM. Subsidiary bodies: Applications Laboratory dedicated to SPM methods in drug discovery and development. Sealed and granted patents: RE 35317; 5,495,109, 5,513,518; 5,515,719; 5,612,491; 5,630,932; 5,621,210; 5,654,546; 5,675,154.

Add: 18536 Office Park Dr. Montgomery Village, MD 20886 Tel: (301) 216-1564 Fax: (301) 869-2199

1909

MOLECULAR MEDICINE, LLC.

E-mail: [email protected]

Add: 9500 Gilman Dr. Bldg. 4, Oster Lane La Jolla, CA 92093-0615

President/CEO: Cecil H. Fox, Ph.D.

Tel: (858) 523-9544

R&D expertise: Research and related products development/manufacture and marketing of virology, gene organization, gene diversity, gene expression, gene discovery and immunology in cells and tissues.

E-mail: [email protected]

Technological expertise: TE, T, AB, C/TC, RD, CH/S, GT Main products/instrumentation under R&D: Molecular probes, proprietary drug, gene expression system, gene knock-out methods, gene mapping, gene vaccine, gene transfer vector.

1908

MOLECULAR IMAGING CORPORATION

Add: 9830 A S.51st St., Ste, 124 Phoenix, AZ 85044 Tel: (602) 753-4311

President/CEO: Charles Prussak, Ph.D. Research director: Jeff Strobel, Ph.D. R&D expertise: Contract development and manufacturing of gene and cell-based products, including viral vector production and cell processing to support clinical trials. Joint ventures: University of California/ Roche. Technological expertise: TE, P/S, BA, C/TC, D-D, GT Principal products/instrumentation: Gene complex, viral protein, viral pesicide, viral vectors.

1910

MOLECULAR PROBES, INC.

Fax: (602) 753-4312

Add: 4849 Pitchford Ave. Eugene, OR 974029165

E-mail: [email protected]

Tel: (541) 465-8300

President/CEO: George Sibbald

Fax: (800) 438-0228

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E-mail: [email protected] Web site: www.probes.com President: Richard P. Haugland, Ph.D. Research director: Richard P. Haugland, Ph.D. R&D expertise: Fluorescent dyes, cell and tissue culture research. Technological expertise: P/S, BS, HTDS, SMC Principal products/instrumentation: PicoGreen®, flu-4, SYPRO® Ruby, SYBRGreen I, LIVE/DEAD, LyQUANT, Fluorescent dyes for labeling proteins and oligonucleotides, secondary detection reagents for immunocytochemistry and FISH, CAT, and lacZ reporter gene detection kits, nucleic acid stains cell viability assays, gluorescent microspheres, fluorescent indicators for Ca2+, Mg2+, Na+ and H+, custom antibody conjugation and immunogen preparation, contract research product, enzyme substrates, protein and nucleic acid quantitation, microplate assays, high throughput screening assay. Subsidiary bodies: Molecular Probes Europe BV, PoortGebouw, Rijnsburgerweg 10,2333 AA Leiden, The Netherlands, Tel: (31) 71-52333-7878; Fax: (31) 71-523-3419.

591

Asia Biomedical Technology, INC. Taipei, Taiwan; Lucerna-Chem Ag, Lucerne, Switzerland; BTS, Homburg, Germany; Choong EL, South Korea; AGP, Australia; Bio/Can, Canada; Euromedex, France. Technological expertise: C/TC, RD, P/S, GA Principal products/instrumentation: TRI Reagents, TRI Reagents LS, Oligo (dT)-cellulose columns, FOR-Mazol®, Methylene Blue Stain, Background Quencher®, TRI Reagents BD, DNAzol ES, DNAzol BD, SuperHyb™ Kit, SuperHyb Kt, Bactozol Kit. Main products/instrumentation under R&D: Nucleic acid isolation and analysis systems, innovative reagents for molecular biology research.

1912

ACCERLRYS, INC.

Add: 10188 Telesis Court, Suite 100 San Diego, CA 92121 Tel: (858) 799-5000 Fax: (858) 799-5100 E-mail: [email protected] Web site: www.accelrys.com Research director: John M. Newsam

1911

MOLECULAR RESEARCH CENTER, INC.

Add: 5645 Montgomery Road Cincinnati, OH 45212 Tel: (513) 458-0900 Fax: (513) 841-0080 E-mail: [email protected] Web site: www.mrcgene.corn President/CEO: Dr. Piotr Chomczynski

R&D expertise: R&D/manufacture of scientific software for biotechnology medicines research. Technological expertise: CH/S, C/TC, BTS, CB, CSDP, ET Principal products/instrumentation: Scientific software, biotechnology medicines, contract R&D products. Main products/instrumentation under R&D: Scientific software for biotech medicine research.

Research director: Dr. Karol Mackey R&D expertise: Development, manufacture and supply of proprietary products used in molecular biology research. Key sales market contracts: Bio-Optica SpA, Milano, Italy; Tal-Rom, Rehovot, Israel; Pan

1913

RIGAKU AMERICAS CORPORATION

Add: 9009 New Trails Dr. The Woodlands, TX 77381-5209

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Tel: (281) 362-2300 Fax: (281) 364-3628 E-mail: [email protected] Web site: www.msc.com President/CEO: Paul Swepston Research director: Joseph D. Ferrara R&D expertise: R&D/manufacture of single crystal X-ray diffraction equipment and biotechnology software. Technological expertise: SMC, CH/S, D-D Principal products/instrumentation: Rigaku R-AXIS II image plate detector; Rigaku RAXIS TV image plate detector; X-stream low temperature device, dTREK, a complete software suite of programs which guides the user through data processing of single crystal X-ray diffraction images, 2008. Main products/instrumentation under R&D: Single crystal X-ray diffraction equipment and biotechnology software.

Key sales market contracts: AMISCAN™ (infarct imaging) by Draximage; Myoscint. Key license and trade contracts: Centocor, Massachussets General Hospital, Northeastern University. Technological expertise: CB, DD, D-D, GT Main products/instrumentation under R&D: Plug & Seal (Immunoliposome), preclinical; PLAY™ (polylys), preclinical; AMISCAN™ (acute Myocardial infarct imaging), Phase I; BTSCAN™ (breast cancer), Phase I; Myoscint, gene therapy. Sealed and granted patents: Imaging areas: 4,952,393, U.S.A.; 4,946,688, U.S.A.; 4,38,502, Bl Europe; 4.55,236 Europe. Therapeutic areas: “Plug & Seal” technology pending.

1915

MOLECULES FOR HEALTH, INC.

Add: 800 E Leigh St Ste 206A Richmond, VA 23219-1551 Tel: (804) 828-6867

1914

MOLECULAR TARGETING TECHNOLOGY, INC.

Add: 882 S. Matlack St., Ste. 105 West Chester, PA 19382-4505

Fax: (804) 828-8566 President/CEO: Howard L. Elford, Ph.D. Research director: Howard L. Elford, Ph.D.

Web site: www.mtarget.com

R&D expertise: Development, manufacture and marketing of novel pharmaceuticals of low molecular weight, with emphasis on new anticancer and antiviral agents, and agents to treat free radical-causing disease.

President/CEO: Chris Pak

Joint ventures: Radic Pharma AB.

Research director: Ban An Khaw

R&D collaboration: Johns Hopkins University Medical Center, Emory University School of Medicine, Karolinska Institute (Sweden), University of Vienna, Virginia Commonwealth University — Medical College of Virginia, Food and Drug Administration (FDA), and University of Kentucky.

Tel: (610) 738-7938 Fax: (610) 738-7928

R&D expertise: Development of imaging products, gene delivery research, related products manufacture. R&D collaboration: Massachussets General Hospital, Northeastern University, Brown University, Stanford University, Yale University, University of Nijmegen, University of Genova, University of Pennsylvania, University of Barcelona.

Technological expertise: D-D, SMC, SY Principal products/instrumentation: Didox anti-cancer drug, antiviral agent, Didox for

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HIV (AIDS) treatment, products for the modulation of ischemia reperfusion injury and mitigation of septic shock, agents for the treatment of psoriasis and prevention of crisis state of sickle cell anemia. Main products/instrumentation under R&D: Agents for organ preservation and transplantation, anti-cancer agents of low molecular weight, neuroprotectors. Sealed and granted patents: Patents for agents which treat cancer, antivirals, ischemia reperfusion injury, sickle cell anemia, septic shock, and neuroprotectors.

1916

MOLOGEN AG

593

Tel: (703) 713-3380 Fax: (703) 713-6668 President/CEO: Dr. Raouf A. Guirguis R&D expertise: Development of healthcare products and research services for drug screening, clinical diagnoses and follow up of cancer and other diseases; therapeutical drugs manufacture. Technological expertise: PPAT, PC, OC Principal products/instrumentation: MonoPrep’s fluid-based prep system optimizes preparations for immunocytochemistry, in situ hybridization, image analysis and other special techniques, human healthcare products, drugs against cancer.

Add: FabeckStr. 30 Berlin D-14195 Germany Tel: (49) 30-841-7880 Fax: (49) 30-8417-8850

1918

MONOMER SCIENCES, INC.

E-mail: [email protected]

Add: Nature’s Way P.O. Box 520 New Market, AL 35761-8941

Web site: www.mologen.com

Tel: (256) 379-5279

President/CEO: Prof. Burghardt Wittig

Fax: (256) 379-5282

Research director: Claas Junghans

President/CEO: Stephen Scaletti

R&D expertise: Development and manufacture of genetic vaccination and gene therapy technologies and products, bioinformatic tools, biotechnology software, etc.

Research director: Stephen Scaletti

Technological expertise: RD, BI, C/TC, DD, GT, HTDS

Technological expertise: PMC, SY, AB, BA, CB, PIS, P/S

Principal products/instrumentation: Minimalistic vectors, bioinformatic sequence analysis, bioinformatic work tool package.

Principal products/instrumentation: Contract manufacturing products, Intermediates for DNA, RNA and RNA-2’OMe protections, phosphites, oligo (dT) cellulose.

Main products/instrumentation under R&D: Various therapy/prophyl drugs, vaccines. Sealed and granted patents: Minimalistic vector technology, several vaccines.

1917

MONOGEN, INC.

Add: 2190 Fox Mill Rd., Ste. 100 Herndon. VA 20171

R&D expertise: Development and manufacture of DNA and RNA intermediates.

1919

MONTANA BIOTECH CORP.

Add: 1740 East Baseline Rd. Belgrade, MT 59714 Tel: (406) 388-0942 Fax: (406) 388-0941 President/CEO: Fred Albert, Ph.D.

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Research director: Joan Combie, Ph.D. R&D expertise: Biotechnology applied research and development of microorganisms from extreme environments for enzyme production and biological processing; related products manufacture. Technological expertise: E, F, AF, FL Main products/instrumentation under R&D: Thermal stable enzymes, pilot plant scaleup and purification, enzyme inhibitor complex, producing enzyme from extreme environment microorganisms.

computer vision chemical analyser, wastewater treatment.

1921

MONTEGEN

Add: 540 Beverly Court P.O. Box 7357 Tallahassee, FL 32301-2506 Tel: (850) 561-0604; E-mail: [email protected] Web site: www.montegen.com President/CEO: Vincenzo Montecucchi Research director: Pier Carlo Montecucchi

1920

MONTECH PTY, LTD.

Add: Level 1, 30 Collins Street VIC 3000 Australia Tel: (61) 3-9903-8859 Fax: (61) 3-9903-8858 President/CEO: Geoff Klestadt Research director: Dr. David Lyster Subsidiary of Monash University. R&D expertise: Technology transfer, commercialization of biotechnological drug conducted at Monash University, products manufacture. R&D collaboration: Australian government, pharmaceutical companies, engineering companies. Key sales market contracts: Biotech, pharma, engineering companies. Key license and trade contracts: Pharmaceutical, engineering. Technological expertise: F, C/TC, RD, P/S, T, GT, BA, GA, H/CF, DD Main products/instrumentation under R&D: Peptides relating to metabolic diseases and angiogenesis, preclinical; monoclonal antibodies for diagnostic assays, preclinical; purification technology for bioprocess, machine condition monitoring technology,

Subsidiary of MONTEGEN, Via G. Dezza n. 24-20144 Milano, Italy. R&D expertise: Development and manufacture of instrumentation for biotech medicines research. R&D collaboration: Talent, S.r.l (Trieste, Italy). Key sales market contracts: Intelligen, INC. (Scotch Plains, NJ, U.S.A.); Talent, S.r.l. (Trieste, Italy); TGA Sciences, INC. (Medford, MA, U.S.A.). Key license and trade contracts: DGS International (Milano, Italy); Max EM Engineering (CA, U.S.A.). Technological expertise: E, F, G, GT, BI, BA, CB, CH/S, SMC, SY Principal products/instrumentation: Instruments for enzymatic catalysis (M.I.E.R.), Kits of reagents for RNA, DNA, and protein purifications, Reagents for DNA analysis (forensic applications). Main products/instrumentation under R&D: Heparin derivatives, clinical Phase I; a novel orthopedic device, protype, clinical evaluation; a pin for oral implantatoprosthesis, protypes, clinical evalution; a multifunctional liquid sensor, protype, preclinical; enzymatic biochips, research, instruments for biotech medicines research.

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Subsidiary bodies: Montegen, Via delle Rosine n. 1,10123 Torino, Italy. Sealed and granted patents: Montegen, a registered service mark.

1922

MONTREAL NEUROLOGICAL HOSPITAL AND INSTITUTE

Add: 3801 University St. Montreal, Quebec H3A 2B4 Canada Tel: (514) 398-6644 E-mail: [email protected] Web site: www.mni.mcgill.ca President: Dr. Richard A. Murphy Research director: Dr. John Robson R&D expertise: Application of academic and clinical neuroscience research institute offering technologies, development and manufacture of biomedical instrumentation for commercial applications. Joint ventures: Genentech, Regeneron, Autoimmune, ISG Technologies, Exogen Neurosdences, Neurovision Sciences. Siemens. Technological expertise: T, C/TC, GT, P/S, RD Principal products/instrumentation: Contract research/clinical trials products, PET, CAT, MRI. Sealed and granted patents: MRI, PET, CAT research/clinical applications.

1923

MORPHOCHEM, INC.

595

R&D expertise: Research of drug discovery, functional proteonics and protein, protein interaction technologies; products manufacture. Joint ventures: Partner Morphochem AG. Technological expertise: E, Q, AF, C/TC, COC, CH/S, D-D, G, HTDS, P/S, RD, R Main products/instrumentation under R&D: TNF2 Receptor antagonist, preclinical; RasRaf inhibitor, preclinical; bacterial topoisomerase inhibitor, preclinical; protein-proteins interaction technologies, modified yeast strain with, increased permeability. Sealed and granted patents: Methods and compositions for a modified yeast strain with, increased permeability and uses thereof, 6,589,773, U.S.; several patents pending.

1924

MORPHOSYS AG

Add: Lena-Christ-Strasse 4882152 Martinsried/Planegg, Germany Tel: (49) 89-8992-7208 Fax: (49) 89-8992-7222 E-mail: [email protected] Web site: www.morphosys.com President/CEO: Dr. Simon Moroney Research director: Dr. Thomas van Ruden R&D expertise: Research of combinatorial biology in drug discovery and target discovery, and related novel products manufacture. R&D collaboration: LeukoSite, Genome Pharm. Comp.

Add: 11 Deer Park Dr., Ste. 116 Monmouth Junction, NJ 08852

Key license and trade contracts: DuPont, Chiron.

Tel: (732) 274-2882

Technological expertise: Q, C/TC, BI, P/S, RD, R

Fax: (732) 274-0086 President/CEO: Prabhawathi Femandes Research director: P. Femandes Subsidiary of Morphochem AG.

Main products/instrumentation under R&D: HuCAL antibody Library, therapeutic antibodies (high throughput antibody generation), combinatorial biology methods in drug

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discovery and target discovery, SIP screening technology.

Key license and trade contracts: Harvard Medical School, Glaxo/Affymax.

Sealed and granted patents: SIP screening technology.

Technological expertise: Q, GA, G, PG

1925

MD BIOSCIENCES GMBH

Add: Postfach, Gewerbestrasse 98132 Egg b. Zürich Switzerland Tel: (41) 044-986-2628

Principal products/instrumentation: Acrydite. Main products/instrumentation under R&D: Molecular biology reagents, clinical diagnostic agents, diagnostic test kits, bridge technology. Sealed and granted patents: Bridge technology.

Fax: (41) 044-986-2630 E-mail: [email protected]

1927

Web site: www.mdbiosciences.com President/CEO: Dr. A. Moradian

MOSHE STAUBER BIOTEC APPLICATIONS

R&D expertise: R&D of clinical diagnostics

Add: 5 Oppenheimer St. Weizmann Science Park Rehovot 76701 Israel

Technological expertise: E, F, PA, BA, P/S, PMC

Tel: (972) 8-936-7001

Principal products/instrumentation: hCG product line, RapiPreg, Preg-well, Apolipoprotein assay, Morwelisa. Main products/instrumentation under R&D: Diagnostic assays, diagnostic enzymes, diagnostic kits, diagnostic reagents, preclinical.

Fax: (972) 8-936-7002 E-mail: [email protected] Web site: www.ms-biotec.co.il President/CEO: Moshe Stauber R&D expertise: Development, manufacture/marketing of biotech medicines products. Technological expertise: C/TC, F

1926

MOSAIC TECHNOLOGIES

Add: 15720 Crabbs Branch Way Suite 2B Rockville, MD 20855 Tel: (240) 399-3900

Principal products/instrumentation: Biotech medicines, vaccines, reagents, enzymes, antibodies, etc. Main products/instrumentation under R&D: Cytokines.

Fax: (240) 399-3904 Web site: www.mosaictechnologies.com President/CEO: Christopher P. Adams Research director: Chris Boles R&D expertise: Manufacture and marketing of clinical diagnostics, molecular biology research. Key sales market contracts: Operon Technologies, IWATA & Co., Eurogentec, Sigma Genosys.

1928

MOUNTAIN VIEW PHARMACEUTICALS, INC.

Add: 3475-S Edison Way Menlo Park, CA 94025-1821 Tel: (650) 365-5515 Fax: (650) 365-5525 E-mail: [email protected] Web site: www.mvpharm.com

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President/CEO: Merry R. Sherman, Ph.D. Research director: Mark G. P. Saifer, Ph.D. R&D expertise: Enhancing potency and heightening safety of therapeutic proteins by site-selective attachment of small numbers of unusually large PEG strands. related novel products manufacture. R&D collaboration: Collaboration with BioTechnology General Corp. to develop PEG-uricase. Collaborations with NCI on PEG-cytoidnes; With ONYX Pharmaceuticals to develop PEG-Adenoviruses. Technological expertise: E, DD, D-D, PMC, P/S, SY Main products/instrumentation under R&D: PURICASE (PEG-uricase), preclinical development; monoPEG-GM-CSF and PEG-SCF, compound optimization, polymer conjugates. Sealed and granted patents: PEG-uricase, pending (~2001); Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates, 6783965, U.S.; PEG-urate oxidase conjugates and use thereof, 6576235, U.S.; polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity, 20080064040, U.S.

597

in transgenic plants, related products manufacture. Key license and trade contracts: EMBL Technological expertise: T, AF, RD Principal products/instrumentation: Agriculture, transgenic plant proteins, biomaterials, contract manufacturing products, antimicrobial resistance engineering peptides, contact research/clinical trial products, biopharmaceuticals, protein biotechnology products. Main products/instrumentation under R&D: Lysozyme derivatives as antimicrobial agents, anaerobic promoter. Sealed and granted patents: LySozyme derivatives as antimicrobial agents; anaerobic promoter and others.

1930

M-FOLD BIOTECH GMBH

Add: Vor dem Kreuzberg 17D — 72070 Tübingen Tel: (49) 7071-998-8741 E-mail: [email protected] Web site: www.m-fold.com/index.htm President/CEO: Mark Lohrmann Research director: Dr. Hans Kiefer

1929

MPB COLOGNE GMBH MOLECULAR PLANT & PROTEIN BIOTECHNOLOGY

Add: Neurather Ring 1 Koein D-51063 Germany Tel: (49) 221-647-010 Fax: (49) 221-647-019 E-mail: [email protected]

R&D expertise: R&D of speed up drug discovery/development for G protein-coupled receptors (GPCRs), products manufacture. Technological expertise: D-D Principal products/instrumentation: Agriculture, biosensors, biopharmaceuticals, veterinary products, G protein-coupled receptors (GPCRS). Main products/instrumentation under R&D: Drug discovery/development route.

Web site: www.mpb-cologne.com President/CEO: Dr. Klaus During R&D expertise: Research of molecular plant and protein biotechnology — molecular farming, antimicrobial resistance engineering

1931

NPS PHARMACEUTICALS

Add: 550 Hills Drive 3rd Floor Bedminster, NJ 07921 U.S.A.

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Tel: (908) 450-5300 Fax: (908) 450-5351 E-mail: [email protected] Web site: www.npsp.com.

Ionic Transport across biological membranes (using-type systems); Electrophoresis; microdialysis; perfusion systems. Main products/instrumentation under R&D: Research apparatus for biotechnology.

President/CEO: Hunter Jackson, Ph.D. Research director: Edward R Nemeth, Ph.D. R&D expertise: Discovery, design & development of small molecule drugs that target ion regulators of important cell functions; related novel products manufacture. R&D collaboration: SmithKline Beecham for osteoporosis.

1933

MRL PHARMACEUTICAL SERVICES

Add: 800 Prudential Dr Jacksonville, FL 32207-8202 Tel: (904) 399-1940

Key license and trade contracts: Amgen and Kirin Brewery for Hyperparathyroidism (HPT).

President/CEO: Laurence R. McCarthy, Ph.D.

Technological expertise: CC, SMC, C/TC, d-D, hTDS

Research director: Daniel Sahm, Ph.D.

Main products/instrumentation under R&D: Calcimimetics, Phase II (HPT); NPS 1776, Phase lb (epilepsy); research in osteoporosis; teduglutide(ALX-0600), treat refractory colitis, PhaseIII, 2008; rhPTH(preosTM, tolambaTM), treat osteosis, Phase IV, 2008; small molecule drugs for regulating cell function.

1932

MRA INTERNATIONAL, INC.

Add: 295 Morris Ave Suite101 Long Branch, NJ 07740 Tel: (732) 222-997

R&D expertise: Surveillance technology research of antimicrobial-resistant organisms, in vitro clinical studies. Key sales market contracts: BioMerieux/The Surveillance Network. Technological expertise: BI, CH/S Principal products/instrumentation: Clinical tests, contract research/clinical trial products; The Surveillance Network, surveillance technology of antimicrobial-resistant organisms.

1934

M-SCAN, INC.

Fax: (732) 229-8897

Add: 606 Brandywine Parkway, West Chester, PA 19380-4278

E-mail: [email protected]

Tel: (610) 696-8210

Web site: www.mrainternational.com

Fax: (610) 696-8370

President/CEO: Tim L Atkins

E-mail: [email protected]

Research director: George L. Atkins

Web site: www.m-scan.com

Subsidiary of Atvestco, INC.

President/CEO: Dr. Howard Morris

R&D expertise: Medical research apparatus development and manufacturing.

Research director: Dr. Mark Rogers

Technological expertise: C/TC, DD Principal products/instrumentation: Apparatus for medical research; Investigation of

R&D expertise: Peptides and peptide instrumentation system, mass spectrometry for protein, glycoprotein, and carbohydrate analysis. Technological expertise: AMS, P, PI, Q, CB

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Principal products/instrumentation: Mass spectroscopy, mass spectrometer for biotechnological drug research, peptide, peptide instruments Main products/instrumentation under R&D: Glycoprotein and carbohydrate analyzer.

1937

599

MSS CLEAN TECHNOLOGY, LTD.

Add: Castle House York Road Sheriff Hutton YORK YO60 6RZ U.K. Tel: (44) 1347-878-877 Fax: (44) 1347-878-878 E-mail: [email protected]

1935

M-SCAN S.A.

Add: 12, Chemin des Aulx,1228 Plan-lesOuates, Geneva, Switzerland.

Web site: www.mss-ct.co.uk President/CEO: Paul Shepherd

Fax: (41) 22-794-8355

R&D expertise: Design, development, fabricates, install, test, balance, certify and validate of modular aseptic cleanroom and containment facilities.

E-mail: [email protected]

Technological expertise: BME.

Web site: www.m-scan.com

Principal products/instrumentation: Aseptic modular wall panels and walkable ceiling panels, mini-environments, isolators, process distribution panels.

Tel: (41) 22-794-8374

President/CEO: H.R. Morris, Ph.D. Research director: L. A. Savoy, Ph.D. R&D expertise: R&D/manufacture of mass spectroscopy for protein, glycoprotein and carbohydrate analysis. Technological expertise: Q, CB, AMS Principal products/instrumentation: Mass spectroscopy, mass spectrometer for biotechnological drug research. Main products/instrumentation under R&D: Carbohydrate analyzer, glycoprotein synthesizer.

Main products/instrumentation under R&D: Modular aseptic cleanroom, aseptic modular containment facilities. Subsidiary bodies: York, Yorkshire, U.K., Tel: (44) 1904-61064, Fax: (44) 1904-660595.

1938

MTEC PHOTOACOUSTICS, INC.

Add: 3507 Oakland Street, Ames, Iowa, 50014 1936

MSRS/AERIE’ CORP.

Tel: (515) 292-7974 Fax: (515) 292-7125

Add: P.O. Box 1397 Key West, FL 33041

E-mail: [email protected]

Tel: (510) 633-4931

Web site: www.mtecpas.com

Fax: (510) 271-5484

President/CEO: Linda M. Seaverson

President/CEO: Robert Weimer

Research director: John F. McClelland Purchasing: Linda Borst

R&D expertise: Development and manufacture of several antibodies and probes. Technological expertise: PA, BI, CH/S Principal products/instrumentation: Primary Antibody Database, MSRS; monoclonal antibodies, polyclonal antibodies, oligonucleotide probe.

R&D expertise: Development and manufacture of photoacoustic detectors for FT1R spectrometers. Technological expertise: AMS, BME Principal products/instrumentation: Photoacoustic detectors, photoacoustic spectrometry.

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Main products/instrumentation under R&D: Photoacoustic detectors for FTIR spectrometers.

1939

MTR TECHNOLOGIES, INC.

Add: 2325 32nd Avenue Brookings, South Dakota 57006 Tel: (605) 692-8188 Fax: (605) 692-8256 E-mail: [email protected] Web site: www.mtrtechnologies.com President/CEO: Dr. Yoni Barnhard R&D expertise: Design and development/ manufacture of fusion proteins. R&D collaboration: Hebrew University, Jerusalem. Technological expertise: SMC, D-D Main products/instrumentation under R&D: RecepTox-GnRH, adenocarcinoma, preclinical; RecepTox-Il2, transplant rejection, preclinical; RecepTox-Fce, allergy and asthma, preclinical; RecepTox-MBP, multiple sclerosis, preclinical; fusion protein, carrier protein, chimeric protein, derived protein, allosteric protein, chimeric toxin. Sealed and granted patents: Chimeric toxins for use in neoplastic targeted therapy, filed 1996; Chimeric proteins with cell-targeting specificity and apoptosis inducing activities, filed 1998.

President/CEO: Serge Plaue, Ph.D. R&D expertise: Custom R&D of peptides and pepudomirnetics, polyclonal and monoclonal antipeptide antibodies, GMP-grade peptides, catalog bioactive peptides, special amino acids, building blocks, turn mimics, peptide instrumentation. R&D collaboration: Contracts with NIDA and NICHD to develop and manufacture selected peptides. Key sales market contracts: Kurabo, Funakoshi. Technological expertise: PA, H/CF, CS, COC, PIS, PA, P/S, CC, SY Principal products/instrumentation: Custom peptide synthesis, GMP-grade peptides, Proton antibody purification kits, custom polyclonal antipeptide antibodies, custom monoclonal antipeptide antibodies, peptide combinatorial libraries, large scale production of research and GMP-grade peptides, pepudomirnetics, catalog bioactive peptides, special amino acids, building tools, turn mimics. Peptide instruments; peptide sequencer, peptide synthesizer Main products/instrumentation under R&D: Pepudomirnetics, novel products, selected peptides.

1941

MUTASCREEN — A DIVISION OF GENETREE

Add: 4015 Fabian Way Palo Alto, CA 94303 1940

MULTIPLE PEPTIDE SYSTEMS, INC.

Tel: (650) 858-2626 Fax: (650) 494-3893 E-mail: [email protected]

Add: 3550 General Atomics Court San Diego, CA 92121 Tel: (858) 455-3710 Fax: (858) 455-3713 E-mail: [email protected] Web site: www.mps-sd.com

Web site: www.mutascreen.com President/CEO: Terry Carrnichael R&D expertise: Mutation detection/screening research. Technological expertise: BI, BS, C/TC, GT, G, Q, P/S, RD, R

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Principal products/instrumentation: Mutatest, mutator, contract research/clinical trial products, MutaScreen mutation detection, high throughput screening.

1942

CHART APPLIED TECHNOLOGIES

Add: 1 Infinity Corporate Centre Dr Suite 300 Garfield Heights, OH 44125 Tel: (440) 753-1490 Fax: (440) 753-1491 Web site: www.mve-inc.com President/CEO: Jon Wikstrom R&D expertise: R&D/product manufacture of cryogenics, low temperature storage, and transportation equipment. Technological expertise: BME Principal products/instrumentation: XLC Freezers w/Tec 2000, IATA Shippers, Cryogenic freezers; Cryogenic purification technique, cryogenic separation technique, cryogenic refrigerator Vapor shippers and LN2 storage equipment.

601

Research director: Dr. Wolfgang Heimberg R&D expertise: R&D of DNA-chip technology, bioinformatics, robotic instruments for laboratory routine, PCR-cycles, SNP-analysis, sequencing, oligonucleotide synthesis, related products manufacture. Joint ventures: Bruker, Macherey & Nagel R&D collaboration: Bruker, Edpidaurus AG, TU Munich, EMBL Key sales market contracts: Affymetrix. Technological expertise: Q, BI, GA, G, P/S, R, SY Principal products/instrumentation: Oligonucleotides, DNA-Chips, HPSF Oligo Chip™ 2000; Thermal Cyclers, Primus™; Robotic Instruments, RoboAmp™; RoboSeq™, RoboPrep™, Automated Biosystems. Main products/instrumentation under R&D: Oligonucleotide synthesizer.

1944

MYCOGEN SEEDS

Add: 9330 Zionsville Road Indianapolis, IN 46268

Main products/instrumentation under R&D: Low temperature storage devices, sensor.

Tel: (800) MYCOGEN

Subsidiary bodies: New Prague, MN & Canton, Georgia.

President/CEO: Carl Fibl, COO

Sealed and granted patents: 4,925,060 Fuzzy Cork; 5,275,007 Sensor Flushing.

R&D expertise: Development and manufacture of seeds for crops with genetically enhanced pest resistance and other value-added characteristics; biopesticides based on Bt and fatty acids.

1943

EUROFINS MWG OPERON

Add: Anzinger Strasse 7 Ebersberg 85560 Germany

Web site: www.dowagro.com Research director: Leo Kim, Ph.D.

R&D collaboration: Pioneer Hi-Bred Btbased pest-resistance in multiple crops.

Fax: (49) 8092-2108-4

Key sales market contracts: Biopesticides — Kubota Corp., Japan Tobicco.; Strategic Alliance — Flanco

E-mail: [email protected]

Technological expertise: F, T, AF, RD

Web site: www.eurofinsdna.com

Principal products/instrumentation: Multiple seed products, including NatureGard corn

Tel: (49) 8092-8289-0

President/CEO: Michael Weichselgartner

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hybrids with Bt and native resistants. Eight biopesticides, including MVP and Scythe herbicide. Main products/instrumentation under R&D: Transgenic corn, cotton, soybean, sunflower, sorghum, canola, wheat, alfalfa with Bt-based pest-resistance, Cellcap system for biopesticides. Sealed and granted patents: More than 60 relating to Bt protein toxins enabling technology for plant expression and Cellcap system for biopesticides.

1945

MYCOPLASMA EXPERIENCE, LTD.

R&D expertise: R&D/manufacture of fermentation extracts of fungi and other microorganisms for natural products drug discovery; scale-up purification and biotransformations of lead compounds. Technological expertise: F, P/S, FE Principal products/instrumentation: Fermentation extracts, ferment. Main products/instrumentation under R&D: Scale-up purification and biotransformation of lead compounds, fungi/microorganisms for natural products drug discovery.

1947

MYCOTOX, INC.

Add: 1 Norbury Rd. Reigate, Surrey RH2 9BY U.K.

Add: 4200 East 9th Ave. Box B-111 Denver, CO 80262

Tel: (44) 1737- 226-662

Tel: (303) 315-4020

Fax: (44) 1737-224-751

Fax: (303) 315-4024

E-mail: [email protected]

E-mail: [email protected]

Web site: www.mycoplasma-exp.com President/CEO: Dr. G. David Windsor

President/CEO: Claude P. Selitrennikoff, Ph.D.

Research director: Dr. G. D. Windsor

Research director: Claude P. Selitrennikoff

R&D expertise: Research of mycoplasma and ureaplasma, related products development and manufacture.

R&D expertise: Research of antifungal drug discovery; contract R&D and related novel products manufacture.

Technological expertise: F, FE

Technological expertise: E, AF, AB, HTDS

Principal products/instrumentation: Mycoplasma and ureaplasma growth media, freeze dried and bulk contract, 1996-NELS range freeze dried biochemical test media for mycoplasma.

Principal products/instrumentation: MycoSelect, a comprehensive antifungal screening package.

1946

MYCOSEARCH, INC.

Add: 4905 Pine Cone Drive Suite 5 Durham, NC 27707 Tel: (919) 489-4700 Fax: (919) 489-3745 President/CEO: Gary Frashier Research director: David Houck

Main products/instrumentation under R&D: MycoTec, fungal diagnostic, preclinical; antifungal drugs, antifungal agent, antifungal drug discovery technologies. Sealed and granted patents: U.S. Patents: 5,521,153 and 4,873,196.

1948

MYELOS CORPORATION

Add: 4940 Carroll Canyon Rd. Suite M, San Diego, CA 92121

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Tel: (619) 657-1040 Fax: (619) 657-1038 President/CEO: Andrew C. Barnes Research director: Fred Esch, Ph.D. R&D expertise: R&D/manufacture of growth factor-derived peptide therapeutics for neurosciences disease therapy. Technological expertise: PIS, D-D, DD, BI Main products/instrumentation under R&D: ProsaptideÔ TX14 (A), growth factor for peripheral neuropathy and neuropathic pain, diabetic peripheral neuropathy pain, Phase II; other neurotrophic factor therapeutics, neuroregulator, neuropeptides, neurotrophic cytokines, neurotrophin (NT).

603

Human CDC14A gene. 6,331,614, U.S.; Chromosome 17p-linked prostate cancer susceptibility gene and paralog and orthologous genes. 6,333,403 U.S.; Screen assay for selecting protein-protein interaction modulators. 6,551,786, U.S.; Reverse-turn mimetics and methods relating thereto. 7,008,941, U.S.; Mating-based method for detecting protein–protein interaction. 6,841,352, U.S.; Chromosome 17P-linked prostate cancer susceptibility gene. 6,844,189, U.S.; Reverse-turn mimetics and composition and methods relating thereof. 6,943,157, U.S.

1950

NABI BIOPHARMACEUTICALS

Add: 12276 Wilkins Avenue Rockville, MD 20852 1949

MYRIAD GENETICS, INC.

Tel: (301) 770-3099 Fax: (301) 770-3097

Add: 320 Wakara Way Salt Lake City, UT 84108. Tel: (801) 584-3600 Fax: (801) 584-3640 Web site: www.myriad.com

E-mail: [email protected] Web site: www.nabi.com President/CEO: David J. Gury Research director: Robert Naso, Ph.D.

Research director: Mark H. Skolnick, Ph.D.

R&D expertise: R&D/manufacture of biopharmaceuticals for therapeutical infectious and autoimmune diseases.

R&D expertise: R&D of genetic testing and gene discovery, related products manufacture.

R&D collaboration: Chiron, Medeva, University of Maryland.

R&D collaboration: Eli Lilly & Co., Bayer, Novartis, Schering/Plough.

Key sales market contracts: Cangene, Catalytica.

Technological expertise: Q, GA, R, BI, PG

Key license and trade contracts: Rh Pharmaceuticals, Cangene.

President/CEO: Peter D. Meldrum

Principal products/instrumentation: BRACAnalysis breast and ovarian cancer genetic test; CardiaRisk Hypertension test.

Technological expertise: BA, D-D, P/S, SMC, COC, PA, F

Main products/instrumentation under R&D: Melanoma genetic test, prostate cancer susceptibility gene, methods for detecting proteins interaction.

Principal products/instrumentation: WinRho SDF™ IIP treatment, Autoplex® T, hemophilia treatment, NABI-HB™, ALOPRIM™, enzymes, antibodies,

Subsidiary bodies: 390 Wakara Way SLC, UT.

Main products/instrumentation under R&D: Nabi-Staph VAX™, S. aureus vaccine; prevention of staphylococcus aureus bacteremia,

Sealed and granted patents: AGT gene mutation; MTSI melanoma gene; BRCAI (~ 2001);

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Phase III; Nabi-Altastaph, S. aureus prevention/ treatment; Nabi-Gvacir, hepatitis C prevention/ treatment; Nabi-Cytera™, RENs — potential antiviral, antimicrobial and antitumor activity; Nabi-NicVAX, Nabi-4600-001.

E-mail: [email protected]

Subsidiary bodies: Research facility: Rockville, MD; Laboratory: Miami, FL

R&D expertise: R&D/manufacture of filtration products, test kits, sample preparation products and sample purification products.

Sealed and granted patents: Full patent portfolio.

1951

NAIAD TECHNOLOGIES, INC.

Web site: www.nalgenunc.com President/CEO: Robert V. Ahlgren Subsidiary of Sybron

Technological expertise: Q, C/TC Principal products/instrumentation: Profil® filter units, MW centrifuge filters, cell sample preparation products, tissue sample purification products.

Add: 2611 SW Third Avenue, Suite 200 Portland, OR 97201 Tel: (503) 274-4407 Fax: (503) 241-0827

1953

NANODESIGN, INC.

CFO: Fred Hall

Add: Suite 300, Research Park Centre 150 Research Lane Guelph, Ontario N1G 4T2 Canada

Research director: Nan Newell

Tel: (519) 823-9088

R&D expertise: R&D of environmental technology methods to manage radioactive and hazardous waste streams.

Fax: (519) 823-9401

President/CEO: Nanette Newell

Technological expertise: BA, C/TC Key sales market contracts: Fisher Scientific exclusive distributor in the U.S. for two products. Principal products/instrumentation: Radaway, FluorAwayÒ, SoloCydeÒ, DabOutÒ. Main products/instrumentation under R&D: DabOut LVS, Phase I; SoloCycle Tissue Processor, Phase II; environmental technology methods. Sealed and granted patents: RadAway.

1952

NALGE NUNC INTERNATIONAL

Add: 75 Panorama Creek Dr. Rochester, NY 14625 Tel: (585) 625-4327 Fax: (585) 586-8987

President/CEO: Ian Anderson Subsidiary of Signal Gene. R&D expertise: Drug design, development and optimization legand base 8 de novo drug design. R&D collaboration: Drug design service agreement with a North American drug discovery company. Technological expertise: CC, COC, CH/S, D-D, G, HTDS, PG, SMC, SY Principal products/instrumentation: Evolutionary molecular design methods. Main products/instrumentation under R&D: Antiestrogens/SERMS, preclinical; antiobesity novo drugs, preclinical; antiangiogenics, preclinical.

1954

NANOGEN, INC.

Add: 10398 Pacific Center Court San Diego, CA 92121

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Tel: (858) 410-4600 Fax: (858) 410-4952 E-mail: [email protected] Web site: www.nanogen.com President/CEO: Howard Birndorf R&D expertise: R&D/manufacture of biochip instrumentation.

605

covalently coupled to Fab antibodies, giving improved penetration and superior immunolabeling, reactive gold particles are available as reagents, as well as golden lipids and silver enhancers, vaccines, enzymes. Main products/instrumentation under R&D: Cytokines, monoclonal antibodies and other biopharmaceuticals.

Joint ventures: Becton Dickinson. R&D collaboration: Aventis Research & Technology; Elan Pharmaceutical; National Institute of Justice. Key license and trade contracts: Many. Technological expertise: W, G, GA, PG, SY, COC Principal products/instrumentation: NanoChip; NanoChip Molecular-Biology Workstation, biochip instruments. Main products/instrumentation under R&D: Biochip instruments, mesoporous permeation layers. Sealed and granted patents: Mesoporous permeation layers for use on active electronic matrix devices, 6960298, U.S.; other patents pending.

1956

NANOSYSTEMS (ELAN DRUG DELIVERY INC.)

Add: 3000 Horizon Blvd. King of Prussia, PA 19406 Tel: (610) 313-5100 Fax: (610) 313-5170 E-mail: [email protected] President/CEO: Larry A. Sterson Research director: Eugene Cooper, Ph.D. Subsidiary of Eastman Kodak R&D expertise: R&D/manufacture of drug delivery- nano particles. Key license and trade contracts: Merck, Astra, Wyeth-Ayerst, Parke-Davis. Technological expertise: X, DD

1955

NANOPROBES, INC.

Add: 95 Horseblock Road, Unit 1, Yaphank, NY 11980-9710, Tel: (631) 205-9490 Fax: (631) 205-9493

Principal products/instrumentation: Drug delivery technique, nanoparticles. Main products/instrumentation under R&D: Particles 4Q nm or below for pharmaceuticals. Sealed and granted patents: Use of particles 4Q nm or below for pharmaceuticals.

E-mail: [email protected] Web site: www.nanoprobes.com President/CEO: James F. Hainfeld, Ph.D.

1957

NATIONAL CANCER INSTITUE

R&D expertise: Research and manufacturing of biopharmaceuticals and pharmaceuticals.

Add: NCI Public Inquiries Office 6116 Executive Boulevard Room 3036A Bethesda, MD 20892-8322

Technological expertise: COC, SMC

Tel: (800) 422-6237

Principal products/instrumentation: Nanogold (1.4 nm) and Undecagold (0.8 nm)

Web site: www.cancer.gov

Research director: Richard Powell, Ph.D.

E-mail: [email protected].

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President: Mr. Mobarak.

Web site: www.ncgr.org

R&D expertise: Development and manufacture of biotechnology medicines and vaccines.

President/CEO: Stephen C. Joseph, M.D.

Technological expertise: RD, C/TC Principal products/instrumentation: TNFalpha for treatment of pre-melanoma. Main products/instrumentation under R&D: γ-fowlpox gp100: 209~217(210M)for treatment of melanoma, Phase III, 2006; γ-fowlpox PSA vaccine to treat prostate cancer, Phase III; γ-vaccinia/g-fowlpox B7·1 vaccine, γ-vaccinia/ g-fowlpox tyrosinase vaccine and ALVACIL-12 vaccine, for treatment of melanoma, Phase II/III; γ-vaccinia MUC1 vaccine to treat breast cancer, Phase II; ALVAC-B7·1 vaccine with stem sep® to treat ovarian cancer and cophoroma, Phase II; B7 transfected allogeneic melanoma cell vaccine for treatment of melanoma, Phase II; carcinoembryonic antigen peptide-1 vaccine for treatment of breast, lung and gastrointestinal tumors, Phase II; Interleukin-4(IL-4) to treat lymphoma and leukemia, Phase II/III; Immunotoxin BL22, Immunotoxin LMB-9, Endostatin, Anti-Tac(FV)PE38 immunotoxin, Anti-transferrin receptor MAb, MAb anti-VEGF, MAb Hu1D10, MART-1 melanoma vaccine, chimeric MAb14·1B, ALVAC-CEA-B7·1, ALVAC- B7·1, Adenovirus P53, Idiotype KLH Lymphoma vaccine, IL-12 plasmid DNA vector, K-ras protein vaccine, myeloma-derived idiotypic antigen vaccine, P53 and RAS vaccine, proteinase 3 peptide vaccine, RAS 5-17 peptide vaccine, vaccinia-CEA 180KD vaccine, VHL peptides vaccine, etc, Phase I~III, 2008.

1958

NATIONAL CENTER FOR GENOME RESOURCES

Add: 2935 Rodeo Park Drive EastSanta Fe, New Mexico 87505 Tel: (505) 982-7840 Fax: (505) 995-4432 E-mail: [email protected]

R&D expertise: Bioinformatics R&D, related novel products manufacture. Technological expertise: BI, G Principal products/instrumentation: Contract R&D products. Main products/instrumentation under R&D: Genome amplification, genomic DNA, genomic library.

1959

NATIONAL COLLECTION OF PLANT PATHOGENIC BACTERIA

Add: Central Science Laboratory, MAFF, Sand Hutton, York YO4 1LZ U.K. Tel: (44) 1904-462-000 Fax: (44) 1904-462-111 E-mail: [email protected] Web site: www.ncppb.com President/CEO and Curator: Dr. D.E. Stead Research director: Dr. D.E. Stead Licensing: Dr. D.E. Stead Subsidiary of Ministry of Agriculture Fisheries & Food. R&D expertise: Plant pathogenic bacteria research; identification technology development of bacteria. Technological expertise: PA, T, BI, GA, RD Principal products/instrumentation: Bacterial cultures, contract research/clinical trial products, plant pathogenic bacteria identification.

1960

NATIONAL COLLECTION OF TYPE CULTURES/HEALTH PROTECTION AGENCY CULTURE COLLECTIONS

Add: Centre for Emergency Preparedness and Response, Porton Down, Salisbury SP4 0JG, U.K.

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Tel: (44) 1980-612-512

Fax: (404) 699-2077

Fax: (44) 1980-611-315

Web site: www.nationaldiagnostics.com

E-mail: [email protected]

President/CEO: L. Mirsky

Web site: www.hpacultures.org.uk

R&D expertise: R&D/manufacture of chemicals and reagents for biotechnology, histological research and liquid scintillation chemicals.

President/CEO: Barry Holmes Subsidiary of Public Health Laboratory Service. R&D expertise: R&D/manufacture of authenticated cultures of biomedical and veterinary importance. Technological expertise: C/TC Principal products/instrumentation: 5,000 bacterial cultures. Main products/instrumentation under R&D: Attenuated culture, fractional culture.

Technological expertise: Q, RD, P/S, GA, PB Principal products/instrumentation: Electrophoresis supplies, liquid acrylamides, agaroses, chemilumenescence detection kits, histology chemicals, liquid scintillation chemicals. Main products/instrumentation under R&D: Reagents for biotech and histological research, diagnostic drugs, liquid scintillation chemicals.

1963 1961

NATIONAL DIAGNOSTIC PRODUCTS PTY, LTD.

Add: 39 Herbert Street St Leonards NSW 2065 Sydney Australia

NATIONAL DISEASE RESEARCH INTERCHANGE (NDRI)

Add: 8 Penn Center 8th Floor 1628 JFK Boulevard Philadelphia, PA 19103 Tel: (215) 557-7361

Tel: (612) 9432-8100

Fax: (215) 557-7154

Fax: (612) 9436-1151

E-mail: [email protected]

E-mail: [email protected]

Web site: www.ndriresource.org

Web site: www.betachek.com

President/CEO: Lee Ducat

President/CEO: Anthony Bransgrove

Research director: Jane S. Schultz, Ph.D.

Research director: Anthony Bransgrove

R&D expertise: Procurement and distribution of human tissue for research.

R&D expertise: R&D/manufacture/marketing of biomedical diagnostics. Technological expertise: E, BA, BI, P/S, SY Principal products/instrumentation: Blood glucose tests. Main products/instrumentation under R&D: Diagnostic agents, diagnostic drugs, diagnostic test kits.

1962

NATIONAL DIAGNOSTICS, INC.

Add: 305 Patton Dr Atlanta, GA 30336 Tel: (404) 699-2121

Technological expertise: C/TC, F Principal products/instrumentation: Contract procurement products, human tissue culture, human tissue factor.

1964

NATIONAL ENGINEERING RESEARCH CENTER FOR TRADITIONAL CHINESE MEDICINE

Add: No. 199 Guoshoujing lu, Pudong New District, Shanghai Zhangjiang High-Tech Park, P. R. China

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Tel: (86) 21-5080-5522

Fax: (417) 546-6433

Fax: (86) 21-3895-3204

E-mail: [email protected]

E-mail: [email protected]

Web site: www.nationalenzyme.com

Web site: http://www. nercmtcm. com

President/CEO: Anthony Collier

President/CEO: Pingxiang

Yang

Summing,

Shen

R&D expertise: R&D of high-new technologies for TCM and new form of prepared drugs and the modernization of the industry. Technological expertise: TCMM, HNT Principal products/instrumentation: Advanced productive technology of Traditional Chinese Medicine and related engineering, high-tech to develop new preparations and new products with the characteristics and advantages of Traditional Chinese Medicine, latest information about engineering technologies, testing technologies, management methods and productive standard of Traditional Chinese Pharmacy, scale-up base for the modernized production for TCMM, scale-up base new technologies including dynamic sub-boiling water extraction system for TCMM, dynamic circulating alcohol extraction system for TCMM, Microwave radiation inducing extraction technologies for TCMM, supercritical fluid extraction systems of TCMM, film coating technologies for TCMM tablet and granule, ultra-fine powder automatic packaging technologies for TCMM, penetrating skin absorption technologies for TCMM, preparation technologies for TCMM soft nano-microcapsule, etc. R&D cooperation unit: Shanghai Traditional Chinese Medicine Technology Co, Ltd; Shanghai Traditional Chinese Medicine University.

1965

NATIONAL ENZYME COMPANY

Research director: Devin Houston, Ph.D. R&D expertise: Development and manufacture of enzyme-based nutritional supplements. Technological expertise: E Principal products/instrumentation: Proprietary method and blends of enzymes, Nizimes; Contract manufacturing products, natural products. Main products/instrumentation under R&D: Enzyme-based nutritional supplements, protease composition for digestive disorder. Sealed and granted patents: Composition and method for treating disease by, increasing activated alpha-2 macroglobulin in the blood and extravascular tissue, 6413512, U.S.; Protease composition and method for treating a digestive disorder. 7067124, U.S.

1966

NATIONAL INSTRUMENT CO., INC.

Add: 4119 Fordleigh Rd. Baltimore, MD 21215 Tel: (410) 764-0900 Fax: (410) 764-7719 E-mail: [email protected] Web site: www.filamatic.com President/CEO: Sidney Rosen R&D expertise: Manufacturing and marketing of packaging equipment, specializing in: integrated liquid filling/capping lines, monobloc systems, capping, pumps. Technological expertise: BME

Add: 15366 U.S. Hwy. 160 Forsyth, MO 65653 Tel: (417) 825-8545

Principal products/instrumentation: Contract manufacturing products, packaging equipment, pumps, monobloc systems.

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1967

NATIONAL INSTRUMENTS

609

Tel: (973) 992-0850 Fax: (973) 992-0827

Add: 11500 N Mopac Expwy Austin, TX 78759-3504

E-mail: [email protected]

Tel: (512) 683-0100

President/CEO: Mark Rolnik

Fax: (512) 683-8411

R&D expertise: R&D/manufacture of laboratory biomedical equipment and supplies.

E-mail: [email protected] Web site: www.natinst.com President/CEO: James Truchard, Ph.D. Research director: Jeff Kodosky R&D expertise: R&D of computer-automated instrumentation. related products manufacture. Joint ventures: Analogic, C&H Technologies, EIP Microwave, Giga-tronics, KineticSystems, MAC Panel Company, North Atlantic Instruments, Virginia Panel, Integrated Control Systems, Kepco, Power-Tek, Transmagnetics, AMP®, Compressor Controls Corp., CYTEC Corp., DSP Technology, INC. Hewlett Packard, Instrumentaion Engineering, INC. TTI Testron, INC. VXIbus Associates, GenRad, Racal Instruments, Tektronix, Wavetek. Key sales market contracts: Honeywell, DITMCO, Westinghouse. Technological expertise: CH/S, AU, CH/S, BME Principal products/instrumentation: Lab View®, Lab Windows®, LabWindows/CVI, HiQ, computer-automated instruments. Subsidiary bodies: Sales offices throughout U.S., Canada; international branch offices: Australia, Belgium, Denmark, Finland, France, Germany, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, U.K., Austria, Mexico, Singapore, Taiwan, Norway.

Web site: www.labscientific.com

Technological expertise: T, F, CB, GA, GT, RD, BME Principal products/instrumentation: Reagents for genetic engineering, enzyme engineering, plant molecular biology, autoradiography, fly facility equipment, gene expression, PCR, laboratory biomedical equipment.

1969

NATIONAL RESEARCH COUNCIL, INSTITUTE FOR BIOLOGICAL SCIENCES

Add: Building M-58 1200 Montreal Rd. Ottawa, Ontario K1A OR6 Canada Tel: (613) 993-9101 Fax: (613) 952-9907 E-mail: [email protected] Web site: www.nrc-cnrc.gc.ca President/CEO: G.H.M. Adams, Ph.D. Research director: Jim Richards, Ph.D. R&D expertise: R&D in immunochemistry and cell biology of neurodegenerative diseases; Fundamental Research of biotechnology products , related novel products manufacture. Joint ventures: R&D Collaboration & Service. R&D collaboration: Multinational pharmaceutical companies, biopharmaceutical companies, biotechnology companies.

NATIONAL LABSOURCE, INC/LABSCIENTIFIC, INC

Technological expertise: E, F, Q, DD, TE, BI, CB, C/TC, D-D, GA, GT, H/CF, P/S, RD, SY, G

Add: 114 West Mt. Pleasant Ave Livingston, NJ 07039

Principal products/instrumentation: Conjugate vaccines; diagnostics; therapeutic targets for neurodegenerative disorders.

1968

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Main products/instrumentation under R&D: Novel liposomes, osteoporosis therapy, blood brain barrier, in vitro model, osteoporosis animal models, stroke animal models, level III bacterial growth facility, ion and ion channels laboratory, immunochemical reagents of neurodegenerative diseases.

1970

NATIONAL RESEARCH COUNCIL, INSTITUTE FOR MARINE BIOSCIENCES

Add: 1411 Oxford Street Halifax, NS B3H 3Z1 Canada

Fax: (972) 8-637-8107 E-mail: [email protected] Web site: www.matimop.org.il/company.aspx President/CEO: H. Goto Research director: Prof. Ami Ben-Amotz R&D expertise: R&D/manufacture of algal products: Dunaliella beta-carotene rich powder for use in health foods, cosmetics and pharmaceuticals. Technological expertise: BA Principal products/instrumentation: Beta carotene rich powder, health foods, natural products.

Tel: (902) 426-8332 Fax: (902) 426-9413

1972

NATURE TECHNOLOGY CORP.

E-mail: [email protected] Web site: www.nrc-cnrc.gc.ca/eng/ibp/imb.html President/CEO: Dr. Arthur Carty Research director: Dr. John van der Meer R&D expertise: Research laboratory development of marine biotechnology with focus on aquaculture, genomics, proteomics and bioinformatics; products manufacture. Key license and trade contracts: Ocean Produce International. Technological expertise: Q, BI, SMC, P/S, G Principal products/instrumentation: Natural marine products, certified standards and reference materials for organic compounds and trace elements, particularly seafood toxins and marine pollutants, in a variety of matrices. Main products/instrumentation under R&D: Aquaculture products, proteome proteoplast.

1971

NATURE BETA TECHNOLOGY, LTD. (N.B.T.)

Add: 4701 Innovation Drive Lincoln, NE 68521 Tel: (402) 472-6530 Fax: (402) 472-6532 E-mail: [email protected] Web site: www.natx.com President: Clague P. Hodgson, Ph.D. Research director: Clague P. Hodgson, Ph.D. R&D expertise: Vector research, design, development, construction and production. Technological expertise: AB, C/TC, COC, DD, GA, GT, G, H/CF Principal products/instrumentation: Retrotransposon vectors, Gene Self-Assembly, Promoter Rescue Technology (PROREST), BiosyntheticViro Vectors. Sealed and granted patents: #5,354,674.

1973

NBL GENE SCIENCES LIMITED

Add: P. O. Box 828 Eilat 88106 Israel

Add: Nelson Ind. Estate South Cramlington, Northumberland NE23 9HL U.K.

Tel: (972) 8-633-1219

Tel: (44) 167-073-2992

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E-mail: [email protected]

Key sales market contracts: Spectrum/ Microgon/Cellco/Dojindo.

Web site: www.1stdirectory.com/Companies/ 85516_NBL_Gene_Sciences.htm

Technological expertise: PA, TE, C/TC, COC, P/S, BA

President/CEO: L McNulty

Principal products/instrumentation: Biochemicals, immunology products, antibodies, ELBA kits, spectrum dialysis, filtration, Microgon™ micro and ultra filtration laboratory and process scales, Cellco, cell culture systems.

Research director: P. Eastlake R&D expertise: Development and manufacture of molecular biology products for the research market. Key license and trade contracts: Yale University, Associated Universities (Brookhaven), Edinburgh and London universities, University of Copenhagen. Technological expertise: R, F, Q, E, RD, P/S

Main products/instrumentation under R&D: Monoclonal antibodies, peptides, cytokines.

1975

NCIMB, LTD.

Principal products/instrumentation: Restriction endonudeases, DNA modifying enzymes, DNA vectors, DNA markers, molecular biology reagents, electrophoresis equipment, liquid handling and plastics, in vitro single stranded DNA and preparation kit

Add: Ferguson Building,Craibstorne Estate, Bucksburn, Aberdeen, AB21 9 YA Scotland

Main products/instrumentation under R&D: In vitro single stranded DNA preparation from supercoiled plasmids. Application in sitedirected mutagenesis and DNA probes, gene mapping in YAGS, DNA extractor, DNA probe, DNA polymerase.

Web site: www.ncimb.com

Sealed and granted patents: International patent application for gpll/exonuclease process, other patents pending.

1974

NBS BIOLOGICALS, LTD.

Add: 14 Tower Square Huntingdon, Cambs PE29 7DT U.K. Tel: (44) 148-043-3875

Tel: (44) 122-471-1100 Fax: (44) 122-471-1299 E-mail: [email protected] President/CEO: Prof. J. I. Prosser, Chairman Research director: Dr. Steve Minter R&D expertise: Chemical and microbiological applied research services, cell/tissue culture sales, bioinformatics, screening, identification, preservation. R&D collaboration: Alliance with applied biosystems to offer microbial identification using Microseq. Technological expertise: F, Q, BI, BA, COC, D-D, G, PMC, R Principal products/instrumentation: Contract R&D products, cell/tissue culture.

Fax: (44) 148-045-9868 E-mail: [email protected] Web site: www.nbsbio.co.uk President/CEO: John Lindsey R&D expertise: Biotechnology product R&D for biomedical research and pharmaceutical customers.

1976

NECTON-COMPANIA PORTUGUESA DE CULTURAS MARINHAS, SA.

Add: Belamanril 8700 Olhad 4100 Portugal Tel: (351) 2-8970-3961

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Fax: (351) 2-8970-3474

Tel: (714) 727-1942

E-mail: [email protected]

Fax: (714) 727-1718

Web site: [email protected]

President/CEO: Greg Dane

President/CEO: Vitor Verdflho

Research director: George Johnson

Research director: Joao Navalho R&D expertise: R&D/manufacture and marketing of human healthcare products.

R&D expertise: R&D/manufacture of bioartificial pancreas for the treatment of Type I diabetes.

Technological expertise: BA, MP

R&D collaboration: Baxter Healthcare Corp.

Principal products/instrumentation: Microalgae biomass, beta-carotene, marine salt, human healthcare products.

Key license and trade contracts: University of Texas, Repligen, MIT.

Main products/instrumentation under R&D: Healthcare drugs.

Main products/instrumentation under R&D: Bioartificial pancreas for the treatment of Type I diabetes, cell/tissue culture.

1977

Technological expertise: C/TC, DD

NEN LIFE SCIENCE PRODUCTS 1979

NEOFILE, INC.

Add: 549 Albany St. Boston, MA 02118-2512 Fax: (617) 482-1380

Add: 1013 White St. Montreal, Quebec H4M 1Y6 AD Canada

E-mail: [email protected]

Tel: (514) 239-5155

Web site: www.nenlifesci.com

Fax: (514) 747-0360

President/CEO: Susan Mazur

E-mail: [email protected]

Research director: Gail Burnett

Web site: www.neofile.com

R&D expertise: Labeling and detection products for life science research.

President/CEO: Joseph Zimmermann

Technological expertise: F, Q, E, D-D, P/S, SY

R&D expertise: R&D/manufacture and marketing of electronic regulatory documents for the pharmaceutical, biotechnology and medical device industries.

Tel: (617) 482-9595

Principal products/instrumentation: Radiochemicals; REFLECTION™ autoradiography film and screen; Renaissance™ chemiluinescence and fluorescent systems for DNA, RNA and protein detection; fluorescent nucleotides, cloned receptors, ELBA, RIA and AIDS research products. Main products/instrumentation under R&D: DNA detection kits.

1978

NEOCRIN COMPANY

Add: 31 Technology Dr., Suite 100 Irvine, CA 92618

Research director: Joseph Zimmermann

Key sales market contracts: Clementi & Associates, Rosemont, PA. Key license and trade contracts: Two in progress. Technological expertise: CH/S Principal products/instrumentation: Electronic drug application, interactive regulatory document, electronic archive. Main products/instrumentation under R&D: Software products for automation of the regulatory documents preparation process.

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Subsidiary bodies: NeoFile U.S.A., INC. 919 Conestoga Rd., Building 3, Ste. 215, Rosemont, PA 19010.

1980

NEOGEN CORPORATION

Add: 628 Winchester Rd. Lexington, KY 40505 Tel: (606) 254-1221 Fax: (606) 255-5532 E-mail: [email protected] Web site: www.neogen.com President/CEO: James L Herbert Research director: Dr. Paul Satoh R&D expertise: R&D/manufacture of test kits for the research, animal safety, clinical and food safety markets. Principal products/instrumentation: BotTox-B vaccine, Ideal instruments; InsightTM test kits, Micro-L1NE® tests; Research ELISA test kits, one-bottle substrates, ELISA screening kits for drug detection in race animals, test kits for food safety.

613

R&D collaboration: SBIR contracts (Phases I and II) with NIH, USDA, and USAF. Technological expertise: PA, BI, BA, BS, GA, CH/S, GT, PMC, P/S, RD Principal products/instrumentation: GasTranTM membranes & modules, AquaProbe™ soil water sensor, biomaterials, biosensors, contract research/clinical trials products, diagnostics, environmental, food processing, human genome project, instrumentation, minerals, natural products, pesticides. Main products/instrumentation under R&D: DNA probe membranes (R&D Phase), gas plasma membrane, gas plasma apparatus. Sealed and granted patents: U.S. patents: 5,439,736 (gas plasma membrane) and 5,472,509 (gas plasma apparatus); other patents pending.

1982

NEOMORPHIC

Add: 2612 B 8th St. Berkeley, CA 94710 Tel: (510) 704-1030 Fax: (510) 704-1013 E-mail: [email protected]

1981

NEOMECS, INC.

Add: 10180 Vikings Dr. Eden Prairie, MN 55344 Tel: (952) 946-0506 Fax: (952) 946-7019 E-mail: [email protected] Web site: www.skypoint.com/neomecsin President/CEO: Dr. Hiroshi Nomura Research director: Dr. Hiroshi Nomura R&D expertise: Research applications of plasma polymerization to membranes for DNA probes, gas separation, bioprocessing, and medical sensors; products manufacture. Joint ventures: DNA probe development with Promega Corporation (Madison, WI).

Web site: www.neomorphic.com President/CEO: Cyrus Harmon Research director: David Kulp R&D expertise: Fundamental research of computational Genomics, R&D/manufacture of biotechnology software. Joint ventures: Celera, TIGR, Systemix. Key license and trade contracts: Genentech, Monsanto, Exelixis, Smithkline Beecham. Technological expertise: BI, CH/S, G Principal products/instrumentation: Genie 2.0, a gene finding system for genomic sequences; The Annotation Station, a state-ofthe-art visualization system for the annotation of genes gene. Neomorphic Genome Sequence Development Kit (NGSDK), a system for largescale DNA sequencing. Data management

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system for large-scale DNA sequencing; Labtrack, a data management.

1983

NEOPROBE CORP.

Add: 425 Metro Place North, Suite 300 Dublin, OH 43017 Tel: (614) 793-7500 Fax: (614) 793-7520 E-mail: [email protected] Web site: www.neoprobe.com President/CEO: David C. Bupp

R&D expertise: Develop, manufacture and marketing of innovative pharmaceuticals to treat critical, unmet medical needs in cancer and cardiovascular diseases. Key sales market contracts: DuPont Merck Radiopharmaceuticals. Technological expertise: RD, P/S, DD, D-D, C/TC, BI Principal products/instrumentation: Verluma™ kit for the preparation nofetumomal merpentan. Main products/instrumentation under R&D: Biostent™ for restenosis, Phase II; Axicidin™ cancer therapy, PhaseII/III.

Research director: David P. Houchens, Ph.D. R&D expertise: R&D/manufacture of radioimmunoguided Surgery (RIGS) cancer detection system.

1985

NEOSE TECHNOLOGIES, INC.

Technological expertise: BME, BI

Add: 102 Witmer Rd. Horsham, PA 19090

Joint ventures: Neoprobe (Israel) with Rotem Industries.

Tel: (215) 441-5890

Principal products/instrumentation: Neoprobe 1000, Neoprobe 1500.

E-mail: [email protected], kgregory@ neose.com

Main products/instrumentation under R&D: RIGS Surgical Phase III trials complete for colorectal cancer, RIGScan CR49 under review with FDA and European regulatory authorities, radioimmunoguided surgery cancer detection system.

Web site: www.neose.com

Subsidiary bodies: Monocarb AB, Lund, Sweden.

Fax: (215) 441-5896

President/CEO: P. Sherrill Neff Research director: Stephen Roth, Ph.D. R&D expertise: R&D/manufacture of carbohydrates for pharmaceuticals and nutrition. Joint ventures: Magnolia nutritionals (Hedge and McNail Speciality Products). R&D collaboration: Abbott Laboratories, Bristol-Myers Squibb, Wyeth Nutritionals.

1984

NEORX CORP.

Add: 410 West. Harrison St. Seattle, WA 98119-4007 Tel: (206) 281-7001 Fax: (206) 284-7112 Web site: www.neorx.com President/CEO: Paul G. Abrams, M.D., J.D. Research director: John Reno, Ph.D.

Technological expertise: E, F, BA, CB, C/TC, P/S, RD, SY Main products/instrumentation under R&D: NE0080 for H. pylori. Glycoconjugation of peptides and factor 8, sialyloligosaccharides. Sealed and granted patents: Carbohydrate production, use methods, composition of matter (~2001); Practical in vitro sialylation of recombinant glycoproteins, 6399336, U.S.; Remodeling and glycoconjugation of peptides,

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7138371, U.S.; Enzymatic conversion of GDPmannose to GDP-fucose, 6500661, U.S.; Factor 8 remodeling and glycoconjugation of factor 8, 7157277, U.S.; Methods for producing sialyloligosaccharides in a dairy source, 6706497, U.S.; (2002~2008).

1986

NEOSYSTEM S.A.

Add: 7 rue de Boulogne Strasbourg 67100 France Tel: (33) 3-8879-0879

615

Subsidiary of ThermoSpectra R&D expertise: R&D and manufacturing of constant temperature equipment. Technological expertise: PG, P/S, SMC, F, Q, C/TC, COC, DD, SY, BME Principal products/instrumentation: Nonrefrigerated Bath/Circulator; Refrigerated Baths/Circulator; Chillers; General Purpose Bath/Portable Condensers. Main products/instrumentation under R&D: Constant temperature cycler, constant temperature sensor.

Fax: (33) 3-8879-1856 E-mail: [email protected]; [email protected]

1988

NETGENICS, INC.

Web site: www.neosytem.fr President/CEO: Serge Plaue Subsidiary of SNPE. R&D expertise: Synthesis R&D/manufacture of peptides, derivatives, and related compounds.

Add: 1717 E. 9th St., Ste. 1600 Cleveland, OH 44114 Tel: (216) 861-4007 Fax: (216) 274-0592 Web site: www.netgenics.com

Technological expertise: PI, CC, PA, SMC, CS, SY, D-D, PS, P/PS

President/CEO: Manuel Glynias

Principal products/instrumentation: Custom peptide synthesis, biologically active peptides for treatment of HTV, SIV peptides — reagents — antibody (custom), amino acids, building blocks.

R&D expertise: Pharmaceutical informatics research, related novel products manufacture.

Subsidiary bodies: GMP facility.

Technological expertise: BI, CH/S, G

Research director: Eric Neumann

Joint ventures: Incyte. Key license and trade contracts: Gene Codes. Principal products/instrumentation: Synergy.

1987

NESLAB INSTRUMENTS/ THERMOELECTRON MEASUREMENT SYSTEMS

Add: 25 Nimble Hill Road, Box 1178, Portsmouth, New Hampshire (NH), 03801-2727

Main products/instrumentation under R&D: Pharmasynthesis, pharmagene.

1989

NET-ID

Tel: (603) 436-9444

Add: 4225 Via Arbolada, Suite 500 Los Angeles, CA 90042

Fax: (603) 436-8411

Tel: (323) 222-1151

E-mail: [email protected]

Fax: (323) 222-7742

Web site: www.neslab.com

President/CEO: Dr. Yves Chauvin

President/CEO: Donald Hanna

Research director: Pierre Baldi

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R&D expertise: R&D of biotech medicine software, novel products manufacture.

Tel: (510) 595-6000

R&D collaboration: SmithKline Beecham, Ecobilan, NTH.

E-mail: [email protected]

Key sales market contracts: Ecobilan Technological expertise: CH/S, BI, COC, BTS, CB Principal products/instrumentation: ProNET — neural network simulator, BioNet — hidden markov model simulator for biological sequence analysis, TEAM — software for comprehensive life cycle analysis. Main products/instrumentation under R&D: Biotech medicine softwares. Subsidiary bodies: 601 Minnesota, Suite 212, San Francisco, CA 94107

1990

NEUREX CORP.

Add: 3760 Haven Avenue Menlo Park, CA 94025

Fax: (510) 595-6006 Web site: www.ntii.com President/CEO: Paul E, Freiman Research director: Lisa U. Carr, M.D., Ph.D., Medical Director R&D expertise: Develop and manufacture of potential therapeutic products based on advances in neuroscience research; Research & development of other biotech medicines. Technological expertise: P, PIS, PS, P/PS Main products/instrumentation under R&D: Memantine, orally-available NMDA receptor antagonist, Phase III; XERECEPT™, synthetic preparation of the human peptide corticotropin-Releasing-Factor (CRF), PhaseII; potential therapeutic drug for diseases of CNS.Viprinex for treatment of acute ischemic stroke, Phase I, 2009.

Tel: (415) 853-1500 1992

Fax: (415) 853-1538 President/CEO: Paul Goddard, Ph.D.

NEUROCHEM W.C.

Add: 72 Frederick- Banting, Ste. 100 Saint Laurent, Quebec H4S 2A1 Canada

Research director: Paul Wood, Ph-D. R&D expertise: CNS biotechnology research and related therapeutic drugs development and manufacture. Technological expertise: Q, D-D, RD, P/S, C/TC, PMC, SY

Tel: (514) 337-4646 Fax: (514) 337-5339 E-mail: [email protected] Web site: www.neurochem.com

Principal products/instrumentation: Corlopam for treatment of cardio-renal.

President/CEO: Dr. Louis R Lamontagne

Main products/instrumentation under R&D: SNX-111 for ischemia following cardiac arrest, closed head injury and analgesia.

R&D expertise: Biopharmaceutical industry, drug products, costumes drugs item R&D and manufacture.

1991

Technological expertise: T, C/TC, COC, DD, D-D, HTDS, CB

NEUROBIOLOGICAL TECHNOLOGIES, INC.

Add: 2000 Powell Emeryville, CA 94806

Street,

Suite

Research director: Dr. Francine Gervais

800

Main products/instrumentation under R&D: Alzhemed™, Phase II completed; Fribrilex™, Phase I completed; CerebrilÔ, Phase I completed.

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NEUROFIT

Add: Le Platon Rue Jean Sapidus Illkirch 67400 France Tel: (33) 3-8865-1606 Fax: (33) 3-8865-1622 E-mail: [email protected] Web site: www.neurofit.com President/CEO: Dominique Gouillon Research director: Dr. Callizot Noelle R&D expertise: Preclinical research and drug discovery/development/manufacture for neurological and psychiatric diseases, (Contract research organization). R&D collaboration: Myocontract; C.E.E. French Ministry of Research.

617

obesity (NPY) drug development; ScheringPlough-schizophrenia drug development; Pfizer-animal health drug development. Key license and trade contracts: Licensed accelerated intelligent drug discovery to Pfizer. Technological expertise: RD, P/S, C/TC, SY, D-D, SMC, R, HTDS, COC, CH/S Main products/instrumentation under R&D: Phase I — drugs for anxiety, sleep disorders, cognition enhancement. Preclinical — obesity and depression.

1995

NEUROMED TECHNOLOGIES, INC.

Key sales market contracts: Biovalky Network.

Add: Don Ripa Building Ste. 301- 2389 Health Sciences Mall, Vancouver, BC V6T 1Z3 Canada

Technological expertise: TE, T, C/TC, PG

Tel: (604) 909-2530

Main products/instrumentation under R&D: Drug for neurological and psychiatric diseases, long-chains fatty alcohols.

Fax: (604) 909-2538

Sealed and granted patents: Long-chains fatty alcohols.

E-mail: [email protected] Web site: www.neuromed.com President/CEO: Natalie E. Dakers Research director: Dr. Terrance Snutch

1994

NEUROGEN CORPORATION

Add: 45 N.E. Industrial Rd. Branford, CT 06405 Tel: (203) 488-8201 Fax: (203) 481-4863 Web site: www.neurogen.com

R&D expertise: Development of novel calcium channel blockers. Technological expertise: C/TC, COC, D-D, HTDS Main products/instrumentation under R&D: Calcium channel blocker, calcium channel antagonist, preclinical.

President/CEO: Harry H. Permer Research director: John Tallman, Ph.D. R&D expertise: Discovery, design and development of novel drugs for psychiatric, metabolic and anti-inflammatory disorders and animal health; Research and development of small molecules; products manufacture. R&D collaboration: Pfizer-anxiety, hypnotic and cognition enhancement drug development,

1996

NEURO PROBE, INC.

Add: 16008 Industrial Dr. Gaithersburg, MD 20877 Tel: (301) 417-0014 Fax: (301) 977-5711 E-mail: [email protected]

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Web site: www.neuroprobe.com

1998

NEUROVIR, INC.

President/CEO: Mark Phillips Research director: Richard H. Goodwin, Jr. R&D expertise: Development and manufacture of chemotaxis devices, high throughput screening devices and specialty devices for cell interaction studies. Technological expertise: C/TC, COC, DD, HTDS, BME Principal products/instrumentation: Boyden chamber; AP48 chamber; ChemoTx® System. Main products/instrumentation under R&D: High throughput screening devices, specialty devices for cell interaction research, chemotaxis devices.

Add: 100-2386 East Mall Vancouver, BC V6T 1Z3 Canada Tel: (604) 822-0577 Fax: (604) 822-0607 President/CEO: Peter G. Ulrich Research director: Jeff Ostrove, Ph.D. R&D expertise: R&D/manufacture of biotech medicines for CNS tumors. R&D collaboration: Cephalon, Aviron. Key license and trade contracts: University of British Columbia, University of Chicago, Georgetown University, Aviron, INC. Technological expertise: PA, E, F, T, D-D, CH/S, C/TC, S, GT, GA, RD, P/S, DD

1997

NEUROSEARCH A/S

Add: Pederstrupvej 93 Ballerup DK-2750 Denmark Tel: (45) 4460-8000 Fax: (45) 4460-8080

Main products/instrumentation under R&D: G207 for CNS Tumors, Phase I; NV-1020 for non-CNS tumors, preclinical; NV-1030 for Gene Delivery using replicating HSV. Sealed and granted patents: Key IP position in replicating Herpes virus.

E-mail: [email protected] Web site: www.neurosearch.com President/CEO: Jorgen Buus Lassen Research director: Leif H. Jensen R&D expertise: Discovery, research, and development of new drugs for the treatment of diseases of central nervous system (CNS), related products manufacture. R&D collaboration: Shire Pharmaceuticals, Meiji Seika. Technological expertise: CC, C/TC, D-D, HTDS, SMC, SY Main products/instrumentation under R&D: Brasofensine, Phase II Parkinson’s disease; NS2710, Phase II, anxiety; NS2389, Phase II, depression; NS2330, Phase I, dementia; NS2359, Phase I, cocaine addiction, other therapeutic drugs for diseases of CNS.

1999

NEW BRUNSWICK SCIENTIFIC

Add: Eppendorf France S. A. R. L., 60, route de Sartrouville 78230, Le Pecq, France Tel: (33) 1-3015-6740 Fax: (33) 1-3015-6745 E-mail: [email protected] Web site: www.nbsc.com President/CEO: Gerry Burgers Subsidiary of New Brunwick Scientific Co., INC. R&D expertise: Development, manufacture and supply of process and equipment to bioindustry and pharmaceuticals. Technological expertise: F, BA, C/TC, CH/S, P/S, PMC

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Principal products/instrumentation: Microbial bioreactors, cell culture reactors, ultra/micro filtration equipment, freezers, shakers. Main products/instrumentation under R&D: Process development and professional equipment for bioindustry and pharmaceuticals. Subsidiary bodies: U.S.A. and U.K. offices.

2000

NEW BRUNSWICK SCIENTIFIC CO., INC.

Add: P.O. Box 4005 44 Talmadge Rd. Edison, NJ 08818-4005 Tel: (877) 723-3317

619

Scientific N.V/SA., ‘t Veldeke 1, B-1970 Wezembeek-Oppem, Belgique, Tel: (32) 02-731-6787, Fax: (32) 02-731-8130; New Brunswick Scientific GmbH, In der Au 14, D-72622 Nurtingen, Tel: (49) 070-22932490, Fax: (49) 070-223-2486; P. R. China — Shanghai, Room 1406 Aijian, No. 1 Buildings, Lane 590, Wan Ping (5) Rd., Shanghai 200030, Tel: (86) 21-6481-1658, Fax: (86) 21-64812665; France — New Brunswick Scientific SARL, IS, Allees de Bellefontaine, 31100 Toulouse, Tel: (33) 5-6143-6543, Fax: (33) 5-6141-5178.

2001

Fax: (732) 287-4222

NEW BRUNSWICK SCIENTIFIC (U.K.), LTD.

E-mail: [email protected] Web site: www.nbsc.com/gen.htm President/CEO: Jim Orcutt CEO: David Freedman Research director: Yiniiang Chen R&D expertise: R&D/manufacturer of equipment for the growth and recovery of cells and their by-products.

Add: 17 Alban Park, Hatfield Road St. Albans, Hertfordshire AL4 0JJ U.K. Tel: (44) 172-785-3855 Fax: (44) 172-783-5666 President/CEO: Nick Vosper Subsidiary of New Brunswick Scientific, INC.

Key sales market contracts: Fisher Scientific, Bohden.

R&D expertise: Development and manufacture of equipment for pharmaceutical research.

Technological expertise: F, BI, C/TC, COC, CH/S, GT, HTDS, PMC

Technological expertise: P/S, BA, C/TC, PMC, COC

Principal products/instrumentation: Biological Shakers, Gyratory Innova®, BioFlo Fermentors, Bioreactors, Calligen Plus®, fibra-CeT®; Microbial Air Samplers, STA.

Principal products/instrumentation: Shakers and shaking incubators, ultra-low temperature freezers, media prep equipment, CO2 incubators, fermentation and cell culture equipment.

Main products/instrumentation under R&D: Equipment for stimulating cell growth, recovery\devices for cell growth by-products.

Main products/instrumentation under R&D: Cell culture bioreactors-benchtop to industrial scale, environmental shakers.

Subsidiary bodies: New Brunswick Scientific (U.K.) Ltd., Edison House, 163 Dixons Hill Rd, North Mymms, Hatfield AL9 7JE, Tel: (44) 017-0727-5733, Fax: (44) 017-0726-7859; New Brunswick Scientific BV, Kerkenbos 1101, 6546 BC Nijmegen, Tel: (31) 024-371 7600, Fax: (31) 024-3717-640; New Brunswick

Subsidiary bodies: Process engineering support.

2002

NEW CHEMICAL ENTITIES, INC.

Add: 18804 North Creek Pkwy., Suite 100 Bothell. WA 98011

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Tel: (425) 424-7250

2004

NEWPORT BIOSYSTEMS, INC.

Fax: (425) 424-7299 E-mail: [email protected]

Add: 1860 Tfainor St. Red Bluff, CA 96080

Web site: www.newchemicalentities.com

Tel: (530) 529-2448

President/CEO: Barry Berkowitz

Fax: (530) 529-2648

Research director: Barry Berkowitz

Web site: www.newportbio.com

R&D expertise: Research of drug discovery, design and development of pharmacogenomics, etc., and related products manufacture.

President/CEO: Rod Roberts

Technological expertise: AF, D-D, BI, AF, CB, G, S, SMC, SY, CoC, PG Principal products/instrumentation: Novel drug products, contract R&D drug products.

2003

NEW ENGLAND BIOLABS, INC.

Add: 240 County Road Ipswich, MA 019382723 Tel: (978) 927-5054 Fax: (978) 921-1350 E-mail: [email protected] Web site: www.neb.com President/CEO: Donald C. Comb, Ph.D. Research director: Ira Schildkraut, Ph.D. R&D expertise: R&D/manufacture of high purity enzymes, reagents and kits for recombinant DNA research and protein analysis; Phospho-specific Ab products for Cell Signaling research, Protein fusion and purification systems, Phage Display peptide libraries.

Research director: Fan Baker R&D expertise: R&D/manufacture of cell and tissue products, culture research, sterile polyethylene bags for storing culture media and other solutions. Sterile fill-bags with fluids, biotech and medical manufacture. Technological expertise: BA, C/TC Principal products/instrumentation: Patented filling systems for sterile filling bags, sterile biobags for storing culture media and other solutions, disposable mixing liners to place in mixing tanks, QC sampling bags and syringes, disposable fluid transfer tubing assemblies, vented serum bottle caps and sanitary fittings, sterile seal device filter assemblies, contract sterile filling of bags, biobags for culture media and other fluids as well as bags for collections of sterile biotech fluids, contract sterile fill medias, alginates and salt solutions; patented assemblies for sterile filling fluids. Main products/instrumentation under R&D: Sterile filling devices for mixing and filling sterile fluids. Sealed and granted patents: Sterile filling device for mixing and filling sterile fluids.

Technological expertise: F, Q, E, LP, RD, P/S, BA, SY, GA, COC Principal products/instrumentation: Biologicals, reagents. Main products/instrumentation under R&D: Native Protein Purification Systems, methods for cloning. Sealed and granted patents: Methods for cloning: 5,200,333; 5,320,957.

2005

NEWPORT ELECTRONICS, INC.

Add: 2229 S. Yale St. Santa Ana, CA 927044426 Tel: (714) 540-4914 Fax: (203) 968-7311 E-Mail: [email protected]

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Web site: www.newportus.com

President/CEO: L William Mcintosh

R&D expertise: Development, manufacture and marketing of panel meters, counters, controllers, and transmitters to measure pH, temperature, pressure, force.

Research director: Dennis Van Epps, Ph.D.

Principal products/instrumentation: Controllers, meters, transmitters, recorders. Main products/instrumentation under R&D: Panel meters, transmitters to measure pH, controllers.

2006

NEW ZEALAND PHARMACEUTICALS, LTD

Add: P.O. Box 1869 68 Weld Street Palmerston North, 4440 New Zealand Tel: (64) 6-952-3800 Fax: (64) 6-952-3801 E-mail: [email protected] Web site: www.nzp.co.nz President/CEO: Dr. Richard P. Garland Research director: Dr. K. Barry Old R&D expertise: Manufacture and marketing of pharmaceutical intermediates and biochemicals. bioprocess engineering research Technological expertise: LP, BA, P/S Principal products/instrumentation: Cholic acid, deoxycholic acid, dehydrocholic acid, sodium salts of bile acids, heparin and related glycosam inoglycans, thymus extracts, ferritin products, peptones, natural taurine, chondroitin sulphate hemin; D-Pinitol, Proeotherg; DChiro Inositol, Echinorea Golastosamine.

R&D expertise: Manufacturing and marketing broad platform of cell selection, detection, expansion and manipulation products to support ex vivo cell therapy in cancer, autoimmune, metabolic and genetic diseases. Key license and trade contracts: New York University (synthetic hypericin). Technological expertise: AB, C/TC, GT, P/S Principal products/instrumentation: Magnetic Cell Selection System, Isolex® 300i; Cytonex™ ImmunoCytoChemistry Staining Kit; Cryocyte™ Freezing Containers, LifeCeLL™ Tissue Culture Flasks. Main products/instrumentation under R&D: Isolex® 300i V.2.0 magnetic cell selection system (positive/negative selection, allogenic); stem cell transplant, Phase III/IV; Hypericin (oral) for glioblastoma multiforme, Phase I/II completed, trials underway; Hypericin (topical) for T-cell lymphoma, warts, psoriasis, Phase I/II ongoing; VM301 (wound healing agent), Phase I completed; cytokine-free culture of dendritic cells, broad platform of cell selection. Sealed and granted patents: Broad portfolio covering CD34 culture (methods, composition, use, antibodies), cell selections, neutrophil precursors, plus exclusive access to Baxter materials patents (~2001); Cytokine-free culture of dendritic cells, 6458585, U.S. (2002~2008); others pending.

2008 2007

NEXIA BIOTECHNOLOGIES, LTD.

NEXELL THERAPEUTICS, INC.

Add: 9 Parker Irvine California CA92618-1605

Add: 21,025 Trans Canada Highway Ste. Anne-de-Bellevue Quebec H9X 3R2 Canada

Tel: (949) 470-9011

Tel: (780) 486-2317

Fax: (949) 586-2420

Fax: (514) 371-7880

E-mail: [email protected]

E-mail: [email protected]

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Web site: www.nexiabiotech.com

Research director: Larry Gold, Ph.D.

President/CEO: Dr. Jeffrey Turner

R&D expertise: Engaged in the discovery, research, development, manufacturing and globalization of products to treat life-threatening diseases, including cancer and infectious diseases.

Research director: Dr. Costas Karatzas R&D expertise: R&D/production of recombinant proteins in the milk of transgenic BELE® goats. Gene expression systems, tissue and cell culture, mammary gland biology. R&D collaboration: BioSteel® product development agreements, various military agencies; Genzyme Transgenics: (i) production of NEX41 using our transgenic BELE® goat system; (ii) purification of NEX41 from the milk of our transgenic BELE goats.

Joint ventures: Sumitomo Pharmaceutical, Co. (AmBisome/Japan-Manufacturing). R&D collaboration: Roche Molecular Systems (PCR application of aptamers) Schering AG, Germany (in vivo imaging diagnostics). Key sales market contracts: Fujisawa U.S.A. (AmBisome/U.S.A. — Marketing).

Technological expertise: TE, T, C/TC, P/S, RD

Technological expertise: AF, COC, DD, D-D, HTDS

Principal products/instrumentation: Transgenic BioSteel®, a strong, light biomaterial, based on spider dragline silk, for use in medical and industrial applications and rh-tPA, a thrombolytic agent.

Principal products/instrumentation: AmBisome (antifungal agent, liposomal amphotericin b), DaunoXome (anti-cancer agent, liposomal daunorubicin).

Main products/instrumentation under R&D: BioSteel®, M & I series; apparatus for spinning spider silk protein, recombinant proteins in the milk of transgenic BELE® goats. Subsidiary bodies: Caprine production facility; Montreal, QC; Caprine Breeding Facility, Plattsburg, NY. Sealed and granted patents: Methods and apparatus for spinning spider silk protein, 7,057,023, U.S.

2009

NEXSTAR PHARMACEUTICALS, INC.

Add: 2860 Wilderness Place Boulder, CO 80301-5415

Main products/instrumentation under R&D: MiKasome (antibiotic, liposomal amikacin), Phase III, VEGF Antagonist, PDGF Antagonist, P-Selectin Antagonist, L-Selectin Antagonist, Complement Antagonist, selex combinatorial process. Subsidiary bodies: Headquartered in Boulder, CO; NeXstar Pharmaceuticals’ R&D facilities, Boulder and Lakewood, CO; San Dimas, CA. Sealed and granted patents: Selex Combinatorial Process.

2010

NEXTRAN, INC.

Add: 303B College Rd. East Princeton, NJ 08540 Tel: (609) 243-0009

Tel: (303) 444-5893

Fax: (609) 520-1235

Fax: (303) 546-7603

E-mail: [email protected]

E-mail: [email protected]

President/CEO: Marvin Miller

Web site: www.nexstar.com

Research director: John Logan

President/CEO: Patrick Mahaffy

Subsidiary of Baxter Healthcare.

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R&D expertise: R&D of xenotransplantation products manufacture. Technological expertise: CB, C/TC Main products/instrumentation under R&D: Ex Vivo Liver Assist Device, Phase I; Xenograft, preclinical; Antibody Removal Column Device, preclinical; heterotopic xenotransplant, R&D.

Technological expertise: HTDS, R Principal products/instrumentation: NSP7000 Multichannel sampling system, Digital Pipettes. Main products/instrumentation under R&D: Liquid handling instruments.

2013 2011

NIABA (NETHERLANDS BIOTECH INDUSTRY ASSOCIATION)

623

NICHIRYO CO., LTD.

Add: 2, Kandamikura-cho, Chiyoda-ku Tokyo 101-0038, Japan Tel: (81) 3-6661-2602

Add: P.O. Box 443, 2260 AK Leidschendam, The Netherlands Tel: (31) 070-337-0464 Fax: (31) 070-337-8765 E-mail: [email protected] Web site: www.niaba.nl President/CEO: Prof. Dr G.M.A. van Beynum R&D expertise: Research of biotech medicines. Technological expertise: C/TC, G, CS Main products/instrumentation under R&D: Contract R&D products, vaccines, peptides, monoclonal/polyclonal antibodies, and other biotech medicines.

2012

NICHIRYO AMERICA, INC.

Add: 230 Route 206 112 Weldon Parkway, Maryland Heights, MO 63043 Tel: (314) 872-9100 Fax: (314) 872-9997 E-mail: [email protected]

Fax: (81) 3-6661-2604 E-mail: [email protected] Web site: www.nichiryo.co.jp President: Yoshito Itoh Research director: Nobuyuki Baba R&D expertise: R&D/manufacture of liquid handling equipment Key sales market contracts: 55 distributors worldwide. Technological expertise: BA, BS, HTDS, RD, R Principal products/instrumentation: Nichipet autoclavable pipettes, Oxford benchmate pipettes, NSR 7000 Automatic Sampling Sys, Nichipet 7000 multi- channel pipettes, NSP7000 Auotomatic Sampling SYS. Main products/instrumentation under R&D: Novel liquid handling equipment. Subsidiary bodies: Nichiryo America, Inc., 230 Route 206, Bldg-i, Ste. 6, Flanders, NJ 07836, Tel: (973) 927-4001, Fax: (973) 9270099, [email protected].

Web site: www.nichiryo.com President/CEO: Sada Tanabe

2014

NICKERSON BIOCEM, LTD.

Subsidiary of Nichiryo Co., Ltd. (Japan). R&D expertise: Development of liquid handling product made by Nichiryo in North America. Service calibration and repair.

Add: Cambridge Science Park, Unit 200 Milton Rd. Cambridge CB4 4GZ U.K. Tel: (44) 1223-423933

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Fax: (44) 1223- 420925

Tel: (530) 666-7186

E-mail: [email protected]

Fax: (530) 666-1416

President: Tina Barsby, Ph.D.

E-mail: [email protected]

Research director: Judy Freeman, Ph.D.

President/CEO: Randolph Nieffenegger

Subsidiary of limagrain Group

R&D expertise: Development and manufacture of cell and tissue culture, other biotechnology medicines.

R&D expertise: Design and development of plant genetic engineering, novel products manufacture. Technological expertise: T, BA, RD, CLTC, AB Main products/instrumentation under R&D: Plant genetic products, specialty biochemicals, plant genetic engineering technologies.

2015

NIDARIA TECHNOLOGY, LTD.

Add: Kinarot, Zemach Jordan Valley 15132 Israel

Key license and trade contracts: Haima Ltd. Technological expertise: PA, BS, C/TC, P/S Principal products/instrumentation: Animal sera, serum albumin, exclusive antisera in rabbits by contract, sera complement, diagnostic reagents, cGMP manufacturing products. Main products/instrumentation under R&D: Growth factor isolation for cell culture application, tissue culture products, biotech drug.

2017

Tel: (972) 4-675-1943

N.I.E. PLANT TISSUE CULTURE LABORATORY

Fax: (972) 4-675-0367 E-mail: [email protected] Web site: www.nidaria.com President: Dr. Amit Lotan Research director: Dr. Amit Lotan R&D expertise: R&D of drug delivery, peptide isolation and synthesis related products manufacture. Technological expertise: PA, DD, PIS, P/S Principal products/instrumentation: Safe SeaTM, Sun block with jellyfish repellent, drug delivery route. Main products/instrumentation under R&D: Drug delivery route, peptide purification and isolation technologies, peptide synthesis products.

2016

NIEFFENEGGER CO.

Add: 1242-D Commerce Ave. Woodland, CA 95776-5916

Add: 529 East 3rd Ave San Mateo, CA 94401 Tel: (415) 348-4240 President/CEO: Richard H. Nakanishi R&D expertise: Micropropagation of plants by plant tissue culture technology on a contractual basis. Technological expertise: C/TC Principal products/instrumentation: Contract work for growers, plant cell culture, plant tissue culture, plant cloning vector, plant micropropagation technique.

2018

NIGU CHEMIE GMBH

Add: Beuthener Straße 2D-84478 Waldkraiburg Germany Tel: (49) 8638-9620 Fax: (49) 8638-9622 E-mail: [email protected]

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Web site: www.nigu.de CEO: R. Firlbeck/Dr. R. Griss Contacts Research director: Dr. K. P. Stengele Subsidiary of SKW-Trostberg AG R&D expertise: R&D/manufacturing of fine chemicals for biotech and pharmaceutical industry. R&D collaboration: FeBiT. Key sales market contracts: SKW Chemicals Inc., U.S.A., SKW East Asia Ltd., Japan, Pluss and Scaufer AG. Key license and trade contracts: ProLigo. Technological expertise: P/S, SY, COC, SMC, AB, BI Principal products/instrumentation: Guanidine Hydrochloride, Guanosine, Guanidine Thiocyanate, Guanidine Salts, Waste Management for biotech-industry, PMSF, Nucleosidespecialties, Mucleotide specialities, Arginine derivatives, bioselect-NIGUTM, a line of high purity fine chemicals.

R&D expertise: R&D/manufacture of nilfisk features portable, industrial HEPA/ULPAfiltered vacuums and floormachines for cleanroom and labuse; portable dry vacuums; wet/dry vacuums; a stainless steel vacuum; mercury vacuums; a semiconductor vapor vacuum; GB-series vacuums for central systems; a floor machine safe for use in cleanrooms without contaminating the area. Technological expertise: C/TC, BME Principal products/instrumentation: Industrial HEPA/ULPA vacuum cleaners. Main products/instrumentation under R&D: Floor machines for cleanroom, Semiconductor Vapor Vacuum, stainless steel vacuum.

2020

NILFISK ADVANCE CANADA COMPANY

Add: 240 Superior Blvd Mississauga, Ontario L5T 2L2 Canada Tel: (800) 668-8400

Main products/instrumentation under R&D: Building blocks for Nucleotide synthesis; building blocks for combinatorial synthesis of DNA-biosensors, fine chemicals for biotech and pharmaceutical industry.

Fax: (800) 263-5111

Sealed and granted patents: Photolithic Building Blocks.

Research director: Kim Azevedo

2019

NILFISK-ADVANCE AMERICA, INC.

Add: 300 Technology Dr. Malvern, PA 19355 Tel: (610) 647-6420

625

E-mail: [email protected] Web site: www.nilfisk.ca President: Bruce Takahashi R&D expertise: Development and manufacture of laboratory, commercial and industrial cleaning equipment. Technological expertise: BME, SI, CS Principal products/instrumentation: Commercial/industrial cleaning equipment Main products/instrumentation under R&D: Laboratory cleaning equipment.

Fax: (610) 647-6427 E-mail: [email protected] Web site: www.nilfisk-advance.com

2021

NIRO, INC.

President: Robert S. Magdelain

Add: 9165 Rumsey Rd. Columbia, MD 21045

Subsidiary of Nilfisk A/S.

Tel: (410) 997-8700

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Fax: (410) 997-5021 E-mail: [email protected] Web site: www.niroinc.com President: Steve Kaplan R&D expertise: Liquid and powder processing supply for the food, dairy, chemical, bioprocessing industries, related novel applied products manufacture. Key sales market contracts: U.S. Filter. Technological expertise: P.S, BA, PMC, CH/S Principal products/instrumentation: Niro chemical recovery systems; spray dryers; evaporators; homogenizers; high pressure pumps; membrane, ceramic filtration; powder packaging, neutraceuticals. Main products/instrumentation under R&D: Liquid and powder processing technologies. Subsidiary bodies: Niro Inc. 1600 O’ Keefe Rd. Hudson, Wisconsin 54016, Tel: (715) 3869371, Fax: (715) 386-9376.

2022

NIZO FOOD RESEARCH

Add: P.O. Box 20 6710BA Ede The Netherlands Tel: (31) 31-865-9511 Fax: (31) 31-865-0400 E-mail: [email protected] Web site: www.nizo.com President: Dr. A.C. Juriarmse Research director: Prof Dr. R.J. Siezen R&D expertise: Biotechnology medicine research, development and manufacture for the food and pharmaceutical industry. Technological expertise: E, F, PA, Q, P/S, RD, AF, BI, BA, CB, GA, G, HTDS, PIS, PMC Principal products/instrumentation: NICE (patented expression system), SURE (patented expression system), patented tailor made bacteriocins, patented food grade vectors. Main products/instrumentation under R&D: Novel biotechnology medicines.

Subsidiary bodies: A fully equipped food grade pilot plant enabling the step to be made from laboratory set-up to production level. Sealed and granted patents: NICE (patented expression system), SURE (patented expression system), patented tailor-made bacteriocins, patented food grade vectors.

2023

NOAB BOIDOSCPVERIES INC.

Add: 2820 Argentia Road, Unit 8 Mississauga, Ontario L5N 8G4 Canada Tel: (905) 814-5238 Fax: (905) 814-5241 E-mail: [email protected] Web site: www.noabdiagnostics.com. President/CEO: Dan Lichtman Research director: Dr. Tom Ewart R&D expertise: R&D/manufacture biotechnological diagnostics.

of

Key sales market contracts: Inter-Medico. Technological expertise: G, HTDS, R, SMC, SY Principal products/instrumentation: Customized microwell plate coating for high throughput screening; coated microwell plates for research; slides for DNA/oligonucleotide microarrays. Main products/instrumentation under R&D: New Lanthanide Cryptate Time-Resolved Fluorescent labels; DNA Microarrays using Lanthanide Cryptate Labels; Microarrays using Nanophors label; New Immunoassay platform, biotechnological novel diagnostics. Sealed and granted patents: Patent pending on core technology.

2024

NONLINEAR DYNAMICS, LTD.

Add: Keel House, Garth Heads Newcastle Upon Tyne Ne1 2JE U.K.

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Tel: (44) 191-230-2121

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NORDION INTERNATIONAL

Fax: (44) 191-230-2131 Add: 447 March Road Kanata, Ontario. K2K 1X8 Canada

E-mail: [email protected] Web site: www.nonlinear.com

Tel: (613) 592-3400

President: Will Dracup

Fax: (613) 592-0571

Research director: Will Dracup R&D expertise: R&D and manufacture of image analysis software for life sciences. Technological expertise: CH/S, BME Principal products/instrumentation: Phoretix ID, Phoretix ID Database, Phoretix 2D, Phoretix 2D Database, Array2, Array Database, Totallab. Main products/instrumentation under R&D: Image analysis software for life sciences.

2025

NORAC TECHNOLOGIES, INC.

Add: Edmonton Research Park 9110-23 Ave, Edmonton Alberta T6N 1H9 Canada Tel: (780) 414-9595

President: James Morrison Research director: Dr. D. Evans R&D expertise: R&D/manufacture of sterilization of biological wastes, immunoassays, radiopharmaceuticals for therapy and diagnosis. Technological expertise: BME, BTS Principal products/instrumentation: Immunoassay products, radioisotopes and gamma radiation processing equipment to sterilize medical devices. Main products/instrumentation under R&D: Sterilization of biological waste, radiopharmaceuticals for therapy and diagnostics.

2027

Fax: (780) 450-1016 E-mail: [email protected]

NORGEN BIOTEK CORP.

Web site: www.noractech.com

Add: 3430 Schmon Parkway Thorold, ON L2V 4Y6 Canada

President/CEO: Richard Caron Contacts

Tel: (905) 227-8848

Research director: Dr. U. Nguyen

Fax: (905) 227-1061

R&D expertise: Development and production of bioingredients for food, cosmetics, pharmaceuticals and biotechnology.

E-mail: [email protected]

Technological expertise: P/S, BTS, CB

Research director: Ms. Nikolina Dobric TM

Principal products/instrumentation: SC ; LabexTM. Main products/instrumentation under R&D: Bioingredients for foods, animal tissue culture, biologicals, commercial food flavor and antioxidant extraction facility, Biomass pharmaceuticals, animal tissue biologicals. Sealed and granted patents: Norac SC process for extraction.

Web site: www.norgenbiotek.com President/CEO: Dr. Yousef Haj-Ahmad R&D expertise: R&D of rapid large scale DNA sequencing/mapping, DNA synthesis and purification; viral growth & purification, custom gene construction and cloning. Contract R&D in molecular biology and virology. Technological expertise: GA, G, P/S, RD, SY Principal products/instrumentation: RNA/ DNA purification kits, an urine (exfoliated cell) RNA purification kit and urine (exfoliated cell)

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DNA purification kit, used to isolate RNA or DNA from as little as 1 ml of urine, 2007; DNA, RNA, and Protein Purification: the procedure allows for the efficient isolation of the four macromolecules in less than 20 minutes with no need to divide the initial sample or lysate. The purified macromolecules are well suited for many downstream applications, 2009; The all-in-one purification kit is designed for isolating RNA, miRNA, DNA, and proteins sequentially from a single sample. The kit enables scientists to isolate total RNA, genomic DNA, as well as total proteins using one column without the need for phenol/chloroform or acetone, 2009. Main products/instrumentation under R&D: Molecular DNA weight markers; DNA/synthesis/purification/isolation kits; DNA transfection kits, rapid large scale DNA sequencing/ mapping, viral growth and purification.

2028

NOR-LAKE SCIENTIFIC

Add: 727 Second St. Hudson, WI 54016 Tel: (800) 477-5253 Fax: (715) 386-6149 E-mail: [email protected] Web site: www.norlake.com President/CEO: DuWayne Bakke R&D expertise: R&D/manufacture and marketing of controlled environment equipment, refrigeration equipment and environmental walkin chambers. Technological expertise: BME Principal products/instrumentation: Refrigeration equipment and controlled environmental equipment. Laboratory refrigerators and freezers blood bank, refrigeration and plasma freezers, incubators, environmental walkins. Main products/instrumentation under R&D: Novel environmental walkin chambers.

2029

NORTH AMERICAN VACCINE, INC.

Add: 10150 Old Columbia Rd. Columbia, MD 21046 Tel: (410) 309-7100 Fax: (410) 381-8456 E-mail: [email protected] Web site: www.nava.com President/CEO: Randal Chase, Ph.D. R&D expertise: Research, design, development, manufacture and marketing of various vaccines for the prevention of human infectious diseases. Technological expertise: F, P/S, CB, COC Main products/instrumentation under R&D: Acceflular Pertussis Vaccines: DtaP — diphtheria, tetanus and pertussis (whooping cough); aP — pertussis (adult booster). Combination vaccines: DTaP-IPV- diphtheria, tetanus, pertussis and polio; DTaP-HIB- diphtheria, tetanus, pertussis and haemophilus influenza type b; DTaP-IPV-HIB- diphtheria, tetanus, pertussis, polio and haemophilus influenza type b. Conjugate vaccines: Group B Streptococcal- neonatal sepsis and meningitis; Meningococcal B — meningitis; Meningococcal C — meningitis; Meningococcal A/C — meningitis; Meningococcal A/B/C — meningitis; Haemophilus influenza type b — meningitis; Group A Streptococcal — streptococcal pharyngitis (strep throat), skin infections, etc.; Pneumococcal — otitis media; Pneumococcal — pneumococcal pneumonia and other novel vaccines for the prevention of human infectious diseases.

2030

NORTH CAROLINA SRT, INC.

Add: 1000 Goodworth DriveApex, NC 27539 Tel: (919) 387-8460

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Fax: (919) 387-8540 E-mail: [email protected] Web site: www.ncsrt.com President/CEO: Henry B. Kopf Research director: Henry B. Kopf R&D expertise: Bioprocess engineering research; development of filtration, liquid chromatography and fermentation systems; distribution of several manufacturers’ filters; related products manufacture.

629

Principal products/instrumentation: Keagents, contract manufacturing products, myco Vue™. Main products/instrumentation under R&D: Prepared microbiological media, fungal isolation/identification system. Sealed and granted patents: Fungal isolation/identification system.

2032

NORTHERN LIPIDS, INC.

R&D collaboration: Schleicher & Schuell, Akzo, Hoechst, Koch Membrane systems.

Add: 8855 Northbrook Court Burnaby, BC V5J 5J1 Canada

Key sales market contracts: AG Technology, Microdyn, Rhone-Poulenc, MFD, Tech-Sep.

Tel: (604) 222-2548

Key license and trade contracts: Software licenses: SmithKline Beecham, Cephalon, Liposome.

E-mail: [email protected]

Technological expertise: F, LP, P/S, BA, PMC, CH/S, C/TC, DD Principal products/instrumentation: Large scale separations, plate and frame filtration device, Optisep®, OptiFiux®, Dualport and quadport filter packs. Main products/instrumentation under R&D: Liquid chromatography and fermentation systems.

2031

NORTHEAST LABORATORIES, INC

Add: P.O. Box 788, 227 China Rd., Waterville, ME 04903-0788 Tel: (207) 873-7711 Fax: (207) 873-7022 E-mail: [email protected] President/CEO: William E. Colby R&D expertise: R&D/manufacture of prepared microbiological media, laboratory research services. Technological expertise: BA

Fax: (604) 222-2563 Web site: www.northernlipids.com President/CEO: T. Redelmeier, Ph.D. Research director: T. Redelmeier, Ph.D. R&D expertise: Manufacturing and marketing of synthetic lipids for pharmaceutical and cosmetic use, primarily for liposome based formulations. Specializing in lipid and liposome analysis under cGMP. Technological expertise: CC, DD, GT, SY Principal products/instrumentation: Phospholipids and synthetic derivatives for pharmaceutical, and biotechnological applications; Biomaterials, chemicals, contract manufacturing products, contract research/clinical trial products, cosmetics, vaccines. Main products/instrumentation under R&D: In vitro liposome delivery systems for bioactive molecules, including lipids, proteins, nucleic acids and antisense molecules, synthetic lipids for pharmaceutical and cosmetic use.

2033

NORTHLAND STAINLESS, INC.

Add: 1119 Bridge St. Tomahawk, WI 54487

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Tel: (715) 453-5326

2035

Fax: (715) 453-5357

NORTON PERFORMANCE PLASTICS CORP.

E-mail: [email protected] Web site: www.northlandstainless.com President: Ara Cherchian R&D expertise: Custom stainless fabrication development of vessels, tanks, heat exchangers for the biotech, pharmaceutical and specialty chemical industries. Technological expertise: BME, CS Principal products/instrumentation: Detergents, biologicals, contract R&D products. Main products/instrumentation under R&D: Vessels, tanks, heat exchangers for the biotech, pharmaceutical and specialty chemical industries.

2034

NORTHFIELD LABORATORIES INC

Add: 1560 Sherman Ave., Evanston, IL 602014800

Add: 2664 Gilchrist Rd. P.O. Box 3660 Akron, OH 44309 Tel: (330) 798-9240 Fax: (330) 798-0358. President: John Ekstrom Research director: Robert Charton R&D expertise: Cell and tissue culture research, manufacturer of plastic tubings, fittings and labware for high purity applications found in research, biotechnology, pharmaceutical and biomedical industries. Technological expertise: C/TC, BME Principal products/instrumentation: Chemware® labware; Chemfluor®® tubing, Tygopure® fittings. High purity flexible sanitary transfer of sensitive fluids, products include Tygon® tubing, PharMed® tubing. Main products/instrumentation under R&D: Cell/tissue culture.

Tel: (847) 864-3500 E-mail: [email protected] President: Sophia Twaddell R&D expertise: Cell and tissue culture research,quality assurance and quality control and preclinical testing services in toxicology, pharmacology, microbiology, analytical chemistry and immunology.

2036

NORTRAN PHARMACEUTICALS, INC.

Add: 3650 Wesbrook Mail Vancouver, BC V6S 2L2 Canada Tel: (604) 222-5577 Fax: (604) 222-6617

Technological expertise: C/TC,DD,D-D

E-mail: [email protected]

Principal products/instrumentation: Contract laboratory testing methods, etc.

President/CEO: Bob Rieder

Main products/instrumentation under R&D: Pivotal Phase III trial for the safety and efficacy of PolyHeme, its human hemoglobin based oxygen-carrying red blood cell substitute, in the treatment of severely injured and bleeding patients.

Research director: Dr. Greg Beatch R&D expertise: Pharmaceutical novel products research and development. Technological expertise: D-D, SMC, SY Main products/instrumentation under R&D: Novel drug products, drug discovery route.

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2037

NOVA BIOMEDICAL

Add: 200 Prospect St. Waltham, MA 024549141

631

R&D expertise: Production and marketing of ornamental plants. R&D collaboration: The Conard-Pyle Co.

Tel: (781) 894-0800

Key license and trade contracts: Drexel University

Fax: (781) 893-6998

Technological expertise: T, AF, C/TC, GA, RD

E-mail: [email protected]

Principal products/instrumentation: Miniature roses, agriculture products.

Web site: www.novabiomedical.com President/CEO: Frank Manganaro Research director: Lloyd Adams R&D expertise: Research, development and marketing of multi-channel, biosensor-based analyzers for both the biotechnology and clinical markets. BioProfile Chemistry Analyzers for rapid analysis of key nutrients, metabolites and gasesin cell culture media, automated analyzers of measure pH, PO2, PCO2, Glutamine, Glucose, Lactate, Ammonium, Sodium, Potassium, Calcium, and Cell Density, On-Line Autoampler, BioProflle Data Management system for individual review or trend analysis.

Main products/instrumentation under R&D: Disease and insect resistant roses for garden use and cut-flower production, epidermal specific promoter. Sealed and granted patents: Epidermal Specific Promoter.

2039

NOVAGEN, INC.

Add: 601 Science Dr. Madison, WI 53711 Tel: (608) 238-6110 Fax: (608) 238-1388

Technological expertise: PMC, R

E-mail: [email protected]

Principal products/instrumentation: BioProfile® 100, BioProflie® 200, BioProfile® 250, On-Line Autosampler.

Web site: www.novagen.com

Main products/instrumentation under R&D: Multi-channel, biosensor-based analyzers of biotechnology and clinical markets; bioprofile chemistry analyzers for rapid analysis of key nutrients, gases in cell culture media.

President: Robert Mierendorf, Ph.D. Research director: Robert Novy Subsidiary of Pel-Freez, Inc. R&D expertise: Bioprocess engineering research; Development and supply of reagents for protein expression, detection and purification. Technological expertise: F, LP, P/S, C/TC

2038

NOVAFLORA, INC.

Add: 25 Lewis Rd West Grove, PA 19390 Tel: (215) 387-5060 Fax: (215) 387-5455 E-mail: [email protected] Web site: www.novaflora.com. President/CEO: Michael S. Dobres, Ph.D.

Principal products/instrumentation: pET system for protein expression in E. coli, BacVector system for protein expression in baculovirus, Single Tube ProteinTM system for in vitro protein expression, T7Select Phage Display System, Biologicals, enzymes. Main products/instrumentation under R&D: Reagents for protein expression, detection and purification, Epitope mapping method, cDNA synthesis method.

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Sealed and granted patents: Epitope mapping method, cDNA synthesis method.

2040

NOVA INSTRUMENTS CO.

Add: 6310 SW Virginia Ave. Portland, Oregon 97201 Tel: (503) 246-8297

Main products/instrumentation under R&D: Bacteriology products, immune diagnostics. Sealed and granted patents: U.S. patents for Uni-Sep and Dipstreak.

2042

NOVA MOLECULAR, INC.

Fax: (503) 246-0360.

Add: 5252, de Mainsonneuv Blvd., West, Suite. 318 Montreal, Quebec H4A 3S5 Canada

Web site: www.novainstruments.com

Tel: (514) 484-7373

President/CEO: Jack Friedland

Fax: (514) 484-0905

Research director: Ben Howison

E-mail: [email protected]

R&D expertise: Development and manufacture of microscopes and spectrophotometer.

Web site: www.nova-molecular.com

Key sales market contracts: Vee Gee Scientific.

Research director: Heimo Scheer

Technological expertise: BME, AMS Principal products/instrumentation: Microscopes, Spectrophotometers. Main products/instrumentation under R&D: Spectrophotometer.

2041

NOVAMED, LTD.

Add: P.O. Box 53231 Jerusalem 91531 Israel Tel: (972) 2-678-1861 Fax: (972) 2-678-1852 Web site: www.novamed.co.il E-mail: info@ novamed.net.il President/CEO: Dr. Emil Katz

President/CEO: Margaret Bywater R&D expertise: Development and manufacture of therapeutic drug for Alzheimer’s disease. R&D collaboration: McGill University, Clinical Microsystems, Geneka. Key sales market contracts: Variagenics. Key license and trade contracts: McGill University, Hoffman LaRoche, Hoechst Marrion Roussel. Technological expertise: Q, C/TC, HTDS, CH/S, AB, BI, GA, RD, R, G, PG Principal products/instrumentation: AntiAlzheimer agent. Main products/instrumentation under R&D: ApoE Polymorphism for treatment of Alzheimer’s disease.

Research director: Dr. Gerald Slutzky R&D expertise: Development and manufacture of bacteriology products, immunodiagnostics, research tools for cell separation. Technological expertise: PA, C/TC Principal products/instrumentation: Uni-sep tubes for lymphocyte separation; rotavirus EIA and latex AGG kits; Aps A-I/Apo B kits for immunoturditimetry; dipstreak — urine dipslide.

2043

NOVASCREEN BIOSCIENCES CORP./CALIPER DISCOVERY ALLIANCES & SERVICES

Add: 68 Elm Street Hopkinton, MA 01748 Tel: (508) 435-49500 Fax: (508) 435-3439

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Web site: www.caliperls.com President/CEO: David M. Manyak, Ph.D. Research director: John Zysk, Ph.D. R&D expertise: Contract research, design and manufacture organization of providing in vitro and in vivo novel drug discovery and development services to the pharmaceutical, biotechnology and academic institutions worldwide. Key license and trade contracts: Licensee to 4,000 marine isolates from Center of Marine Biotechnology to test in receptor binding assays for the discovery of novel pharmaceutical and industrial products. Technological expertise: F, RD, C/TC, CH/S Principal products/instrumentation: Drug discovery and research/development services to the pharmaceutical, biotech, food/agriculture, and cosmetic industries, including 145 receptor binding assays (including human cloned receptors). R&D Services include: PROFILE®, HITS® (High Throughput Screening), and Customized Screening, cell biology services, functional, enzyme, in vivo and antimicrobial assays. Main products/instrumentation under R&D: Additional receptor binding, enzyme, functional, and in vivo assays, receptor binding assays for the discovery of novel pharmaceutical and industrial products.

633

preparative scale. Manufacture of industrial chromatographic preparative systems (SMB, HPLC, SFC, GC). Joint ventures: IFPC French Institute of Petroleum. Technological expertise: P/S Principal products/instrumentation: HPCC, SMB, SFC systems and columns, Prochrom™; Purification. Main products/instrumentation under R&D: DAC columns, industrial chromatographic preparative systems, chromatographic purification technologies on a preparative scale. Subsidiary bodies: Sales, R&D: 5, rue Jacques Monod; B.P.9, 54250 Champigneulles, Tel: (33) 3-83 38-8630, Fax: (33) 3-83388640; NovaSep Inc. Gibbstown, U.S.A. Sealed and granted patents: DAC (Dynamic Axial Compression) columns.

2045

NOVATECH, INC.

Add: 345 Farnum Pike, Smithfield, RI 02917 Tel: (401) 233-0010 Fax: (401) 233-0098 E-mail: [email protected] Web site: www.novatechinc.com President: Gloria J. Thesenvitz

2044

NOVASEP

Research director: Jack Clark

Tel: (33) 383-497-130

R&D expertise: Development and manufacture of animal serums, media and bovine pharmaceutical grade fully traceable origin components.

Fax: (33) 383-497-140

Technological expertise: C/TC

E-mail: [email protected] President: Roger-Marc Nicoud

Principal products/instrumentation: Fetal Bovine Serum, Formula Fed Calf Serum, Donor Calf Serum Pharmaceutical Grade, Tissue Culture Medias.

R&D expertise: Industrial chromatography design; Research and development of chromatographic purification technologies on a

Main products/instrumentation under R&D: Animal serum, bovine pharmaceutical grade fully traceable origin components.

Add: 82, Boulevard de la Moselle BP 50 — 54340 Pompey FRANCE

Web site: www.novasep.com

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NOVAVAX, INC.

Add: 9920 Belward Campus Drive Rockville, MD 20850

Main products/instrumentation under R&D: Extensive range of monoclonal antibodies under R&D using recombinant proteins; DNA probes; Primer sets, immunodiagnostics.

Tel: (240) 268-2000 Fax: (240) 268-2031 E-mail: [email protected] Web site: www.novavax.com President/CEO: John A. Spears Research director: D. Craig Wright R&D expertise: biopharmaceuticals R&D and manufacture. R&D collaboration: ParkeDale Pharmaceuticals; CANTAB. Technological expertise: DD, D-D Main products/instrumentation under R&D: Hormone Replacement, Phase III-IV; microensapulation technology; bioprecursor prodrug. Sealed and granted patents: Micro-ensapulation technology.

2047

NOVOCASTRA LABORATORIES, LTD.

Add: Ballial Business Park Bentent Lane Newcastle Upon Tyne NE12 8EW U.K. Tel: (44) 191-215-0567 Fax: (44) 191-215-1152 E-mail: [email protected] Web site: www.ebiotrade.com President/CEO: Prof. C.H.W. Home Research director: Dr. I. Milton R&D expertise: R&D/manufacture of immunodiagnostics, monoclonal antibodies, DNA probes, etc. Key sales market contracts: Worldwide distributor network. Technological expertise: PA, C/TC, GA, H/CF, P/S, RD

2048

NOVO NORDISK A/S

Add: Novo Alle Bagsvaerd, 2880 Denmark Tel: (45) 4444-8888 Fax: (45) 4444-0555 Web site: www.novonordisk.com President: Steen Riisgaard Research director: Soeren Carlsen R&D expertise: Industrial enzymes applied research, development and manufacture. Technological expertise: E, ET, ERT Principal products/instrumentation: Aquazym®; Aquazym Ultra; Cellusoft®; Denimax®; Novolan®; Termamyl®, Thermozyme®; TerminoxTM Ultra; AMG (Amyloglucosidase Novo); BAN (Bacterial Amylase Novo); DextranaseTM; Dextrozyme®; Finizym®; Fructozyme® L; Fungamyl®; MaltogenaseTM; Promozyme®; ShearzymeTM; Sweetzyme®; Terrnamyl® Type LS; ToruzymeTM; Aquazyme® 120 L, BAN 480 L and Fungamyl® 800 L; Novozym® 342; PulpzymeTM HC; Resinase® A 2X; Alcalase®, Neutrase®, Esperase®, ProtamexTM, Savinase®, Novozym® FM; PlavourzymeTM; PTN (Pancreatic Trypsin Novo); PEM (Proteolytic Enzyme Mixture); Greasex®; NovoCorTM AD; NUE (Novo Unbarring Enzyme); Pyrase®; NovoCor AB; NovoCorTM S; LecitaseTM; Novozym® 435; Lipozyme® IM; Novozym 388; Novozym 398; Novozym 868; Bio-Feed® Plus; Bio-Feed Beta; Bio-Feed Alpha; Bio-Feed Pro; Bio-Feed wheat, Energex®; Phytase Novo; Alcalase®; Savinase®; Durazym®; EverlaseTM; Esperase®; LipolaseTM; Lipolase Ultra; Duramyl®; Celluzyme®; Cereflo®; Ceremtix®; Maturex®; Neutrase®; UltrafloTM; Viscozyme®; Fungamyl Super; Gluzym®; Novozym® 677 BG; PentopanTM; Fungamyl®

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800 L; LiquozymeTM; SAN Super; Terrnamyl® 120 L. Main products/instrumentation under R&D: Various novel industrial enzymes.

2049

NOVO NORDISK BIOTECH., INC.

Add: 1445 Drew Ave. Davis, CA 95616 Tel: (916) 757-8100 Fax: (916) 758-0317 E-mail: [email protected] President: Glenn E. Nedwin, Ph.D. Subsidiary of Novo Nordisk A/S. R&D expertise: Development and manufacture of industrial biotechnology/medicines. Technological expertise: F, Q, E, RD, P/S, BA, GA, SY, E Principal products/instrumentation: Levemir Insulin detemir for once or twice-daily subcutaneous administration in the treatment of adult patients with Type 1 or Type 2 diabetes mellitus who require basal (long-acting) insulin for control of hyperglycemia, 2008. Main products/instrumentation under R&D: Recombinant expression technology; new detergent, textile and pulp and paper industry related enzymes, novel biotechnology medicines.

Principal Produces/instrumentation: Insulin and diabetes care products, Norditropin®, somatropin(rRNA origin) for injection (human growth hormone) to treat growth failure in children due to inadequate growth hormone secretion; Novolin®70/30, 70% NPH human insulin isophane suspension and 30% regular, human insulin injection (recombinant DNA origin) for treatment of insulin-dependent diabetes mellitus; Novolin®L Lente®, human insulin zinc suspension (recombinant DNA origin) to treat insulin-dependent diabetes mellitus; Novolin®N NPH, human insulin isophane suspension (recombinant DNA origin) for treatment of insulin-dependent diabetes mellitus; Novolin®R regular, human insulin injection (recombinant DNA origin) to treat insulindependent diabetes mellitus; Novoseven® coagulation factor VIIa (recombinant human protein)for treatment of bleeding episodes in hemophilia A or B patients with inhibitors to factor VIII or factor IX; GlucagenTM, glucagon (rDNA origin) for injection to treat hypoglycermia and for use as a diagnostic aid, tabletting machines, Vaccine production equipment, Chromatography columns, Chromatography media, Sterility test devices. Main products/instrumentation under R&D: Insulinotropin for treatment of Type 2 diabetes, Phase II, 2008.

2051 2050

NOVO NORDISK PHARMACEUTICAL, INC.

NOVOPHARM BIOTECH, INC.

Add: 10 Four Seasons Place, Suite 501, Toronto, Ontario, M9B 6H7, Canada

Add: 100 College Rd. W, Princeton, NJ

Tel: (416) 291-1277

Tel: (609) 987-5800

Fax: (416) 291-9306

Fax: (609) 921-8082

E-mail: [email protected].

R&D expertise: R&D and manufacture of pharmaceuticals and instrumentation/ equipment.

President: Dr. Albert Friesen

Technological expertise: C/TC, DD, D-D, GT, BME.

635

Research director: Dr. Howard Kaplan R&D expertise: R&D/manufacture of human monoclonal antibodies and generic biopharmaceuticals.

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Joint ventures: Warrick Pharmaceuticals/ Shering Plough-Generic Biopharmaceuticals, Breas Tek Inc — breast cancer screening agent, Novopharm Ltd. R&D collaboration: Genzyme Transgenics, NRC, University of Manitoba, Saskatoon Cancer Centre, University of Nebraska Medical Center. Key license and trade contracts: McGill University — human antibody technology; University of California-MAb, University of Alabama- MAb. Technological expertise: F, H/CF, RD, Q, BI, GA, BA, C/TC, COC, CH/S, D-D

Main products/instrumentation under R&D: Clean room furnishings.

2053

NUAIRE, INC.

Add: 2100 Fernbrook Ln. Plymouth, MN 55447 Tel: (763) 328-3352 Fax: (763) 553-0459 E-mail: [email protected] Web site: www.nuaire.com. President: Richard Peters

Main products/instrumentation under R&D: Monopharm C, Phase I; HII-scfv, Phase I; Novomab G2 Phase I; 4B5 Phase I.

R&D expertise: R&D/manufacture of biological safety cabinets, CO2 incubators, ultralow freezers, laminar airflow equipment.

Subsidiary bodies: 147 Hamelin St, Winnipeg, Manitoba, Canada R3T 3Z1, Tel: (204) 4781023, Fax: (204) 452-7721; 520, 11th Street South, Birmingham, AL 35294, U.S.A.; 6190 Cornerstone Court £., Ste. 106, San Diego, CA 92121, U.S.A.

Principal products/instrumentation: Biological Safety cabinets (LAB-GARD), bioremediation, biosensors, CO2 water-jacketed incubator (Autoflow), Ultraflow Freezers.

Sealed and granted patents: 5,637,493; 5,639,863.

2052

NTA INDUSTRIES, INC.

Main products/instrumentation under R&D: Laminar airflow equipment.

2054

NUCLEAR ASSOCIATES

Add: 100 Voice Road Carle Place, NY 11514 Tel: (516) 466-8257

Add: 8069 Belmont Ave.Belmont, MI 49306

Fax: (516) 741-5414

Tel: (616) 863-9115

E-mail: [email protected]

Fax: (616) 863-9127

Web site: www.nucl.com

E-mail: [email protected]

President: Martin J. Ratner

Web site: www.ntaindustries.com.

R&D expertise: Development and manufacture of medical imaging instruments and accessories.

President/CEO: Malcolm B. Northrup R&D expertise: Bioprocess engineering research, clean room furnishings production. Technological expertise: BP, AU Principal products/instrumentation: Stainless steel furniture, ULTRA-CLN®; Ultra clean stainless furnishings.

Technological expertise: TE, PMC, BME Principal products/instrumentation: CLEAR PbTM Lead Plastic. Main products/instrumentation under R&D: Medical imaging instruments, image sensors.

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2055

NUCLEOTECH CORPORATION

Add: 1400 Fashion Island Blvd., Ste. 510 San Mateo, CA 94404/957 Industrial Road Suite R, San Carlos, CA 94070 Tel: (650) 554-1800

637

Main products/instrumentation under R&D: Nutraceuticals, nutritional supplements.

2057

NUGEN TECHNOLOGIES, INC.

Fax: (650) 554-1808

Add: 821 Industrial Road, Unit A San Carlos, CA 94070 U.S.A.

E-mail: [email protected]

Tel: (650) 590-3600

President/CEO: Gary Alianell, Ph.D.

Fax: (650) 590-3630

R&D expertise: Advanced bioimage information to the lifesciences; related novel products development and manufacture.

E-mail: [email protected]

Technological expertise: Q, BI, CH/S, G, HTDS Principal products/instrumentation: NucleoVisionTM — Bioimaging Workstation, GelExpertTM Software — Biomedical imaging software, NucleoScanTM Realtime Electrophoresis and Imaging System. Main products/instrumentation under R&D: GINA® Advanced Bioinformatics Software.

2056

NUCYCLE THERAPY, INC.

Add: 1 Deer Park Dr, Suite M Monmouth Junction, NJ 08852

Web site: www.nugeninc.com Research director: J.F. Tobey, Jr. R&D expertise: Acclimating, developing, selection, and production of medical microorganisms, laboratory enzyme bacterial testing. Technological expertise: F, FL, BME Principal products/instrumentation: BTEX; other aromatics and light mineral oils, glycols and some pesticides; Maxicell, Cellulase, Alkapro alkaline protease, Lipidase-lipase; contract manufacturing products Main products/instrumentation under R&D: Medical microorganisms, laboratory enzyme bacterial testing methods.

Tel: (908) 438-0900 Fax: (908) 438-1209 E-mail: [email protected] Web site: www.nucydetherapy.com.

2058

NUMERICAL ALGORITHMS GROUP (NAG), LTD.

President/CEO: Burt Ensley

Add: Wilkinson House Jordan Hill Road Oxford, Oxon OX2 SDR U.K.

Research director: Burt Ensley

Tel: (44 ) 186-551-1245

R&D expertise: Development and manufacture of nutritional supplements.

Fax: (44) 186-531-0139

Joint ventures: Chem International.

Web site: www.nag.co.uk.

R&D collaboration: Rutgers University

CEO: Brian Ford

Technological expertise: BA, T, RD

R&D expertise: R&D/manufacture of scientific Software.

Principal products/instrumentation: PhytoChrome, PhytoSel.

E-mail: [email protected]

Technological expertise: BME, CH/S, BTS

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Principal products/instrumentation: Robust and accurate software for numerical computation and visualization, a range of programming tools and compilers. Main products/instrumentation under R&D: Novel scientific software for life science research.

2059

NUTRACEUTIX, INC.

Add: 9609 153rd Ave. NE Redmond, WA 98052 Tel: (425) 883-9518 Fax: (425) 869-1020 E-mail: [email protected] Web site: www.nutraceutix.com President/CEO: David T. Howard Research director: William D. St John R&D expertise: Manufacturing, research and development of microbial, nutritional and plant-based products for animal, human health and food applications. Key sales market contracts: Biotol, IncCobactin microbial feed additive. Key license and trade contracts: Obtained: BioChemix, Inc-Calcium D-glucarate™; Temple University-Controlled Delivery Technology™. Distributed: METRx, Recall, Amrion, Twinlabs, Vita-Health, Country Life, Highland Labs. Technological expertise: F, DD, FL Principal products/instrumentation: Contract manufacturing products, natural products, nutraceuticals, cobactin® microbial feed additive, Bio Power® silage inoculant, Calcium Dglucarate™, LIVEBAC® BaCCineTM calcium D-glucarateTM. Main products/instrumentation under R&D: Cobactin® microbial feed additive for poultry, nutritional/plant based products for human health care.

Subsidiary bodies: Lafayette, Colorado. Sealed and granted patents: U.S. 5,139,792 — method and system for dispensing live bacteria into animal feed and drinking water; BT1389™ U.S. 5,179,020 — antibiotic resistant strain of lacto-bacillus acidophilus; U.S. 5,256,425 — antibiotic resistant strain of lactobacillus acidophilus; U.S. 5,358,145 — dispenser for delivering micro-ingredients from cartridges; Canada 1,298,799 — strains of lactobacillus acidpohilus molecular strength, S.E.T., Cool-Tab, Bio-Tract, MDT, Cobactin E, Co-Epo; U.S. 4,845,123 — reduction in vivo of the in appropriate levds of endogenous and environmental-derived compounds by sustained-release inhibitors of B-glucuronidase; Trademarks: BaCCine; Bio Techniques; Bio Power; BT1386; BT5100; Cobactin Plus; Cobactin II; Cobactin; CDT; Live-Bac; MDT; Nutraceutix.

2060

NUTRI-QUEST, INC.

Add: 1400 Elbridge Payne Road Ste. 110 Chesterfield, MO 63017 Tel: (314) 537-4057 Fax: (314) 532-1710 E-mail: [email protected] President/CEO: Kohta Fujiwara Research director: Dr. Kazuyuki Koide Subsidiary of Kyowa Hakko/Japan. R&D expertise: Research & development of enzymology and enzymetic technique, related novel products manufacture.. Technological expertise: E, F, ET, FL, ERT Principal products/instrumentation: Contract research/clinical trial product, food processing method, natural products, veterinary products. Main products/instrumentation under R&D: Enzymetic thchnique, enzyme drug, enzyme

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activator, enzyme inhibitor, enzyme preparation.

2061

NYCOMED

Add: Leutschenbachstrasse 95 8050 Zurich Switzerland Tel: (45) 4677-1018

639

Principal products/instrumentation: Mass®, membrane based bioseparation devices; Automass®, separation instruments. Main products/instrumentation under R&D: Bioseparation technology.

2063

OCEANIX BIOSCIENCES CORP.

Fax: (45) 3010-0455

Add: 7170 Standard Dr. Hanover, MD 21076

Research director: Ole W. Christensen

Tel: (410) 712-4411

Major partners: Schering-plough, Amgen, Celltech.

Fax: (410) 712-4412

R&D expertise: Applied technology for improvement of biotechnological processes and protein purification, expression technology for bacterial fermentation, plasmid stabilization, E. coli expression technology.

President/CEO: David M. Manyak, Ph.D.

Key license and trade contracts: ScheringPlough, Celltech, Amgen. Technological expertise: E, F, P/S, RD, LP, AF Principal products/instrumentation: RAPTTM runaway replication plasmid technology, RST replicon stabilization technology, Benzonase® nuclease for degradation of RNA/DNA, enzymes. Main products/instrumentation under R&D: Protein purification/expression technology for bacterial fermentation, E.coli expression technology.

2062

NYGENE CORP.

Add: P.O. Box 429 7 Sullivan Rd. Goldens Bridge, NY 10526 Tel: (914) 964-8300 Fax: (914) 964-9891

E-mail: [email protected] Research director: Peter Carlson, Ph.D. R&D expertise: Discovery/design/development/manufacture and marketing of natural product-based novel pharmaceuticals and novel enzymes and biomaterials from marine organisms. Key license and trade contracts: Broad technology licensing agreement with University of Maryland, Maryland Biotechnology Institute, and Center of Marine Biotechnology. Technological expertise: F, E, D-D, CH/S, RD, P/S, H/CF, C/TC, SY, CH/S Main products/instrumentation under R&D: Receptor and enzyme screening technology for the discovery and development of novel pharmaceuticals from marine bacteria and other marine sources. Primary therapeutic focus includes CNS disorders, antiinfective and anticancer agents. Oceanix also applies marine microbes as a source for discovery of industrial enzymes and biomaterials, from marine organisms. Subsidiary bodies: Novascreen division.

President: Frank P. Brunetta 2064

OCEAN OPTICS, INC.

R&D expertise: R&D and manufacture of membrane-based bioseparation devices/ instrumentation.

Add: 830 Douglas Ave. Dunedin, FL 34698

Technological expertise: PA, P/S, BA, CH/S

Tel: (727) 733-2447

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Fax: (727) 733-3962 E-mail: [email protected] Web site: www.oceanoptics.com President: Michael Morris Research director: Roy Walters, Ph.D. R&D expertise: R&D/manufacture and marketing of low-cost, fiber optic analytical instrumentation, including miniature CCD-array spectrometers and spectrophotometric accessories, for markets including R&D, process control, pharmaceuticals analyses and medical diagnostics. Technological expertise: E, F, SMC, BA, CH/S, PMC Principal products/instrumentation: Miniature CCD and photodiode array spectrometers; spectrometer operating platforms for desktop PCs, notebook PCs and devices supporting serial port interface; fluorescence and Raman Spectrometers; hundreds of light sources, sampling optics, fibers, sensors and other accessories. Main products/instrumentation under R&D: Novel low-cost, fiber optic analytical instruments. Subsidiary bodies: Manufacturing plant in Orlando, FL.

2065

OCTOPLUS N.V.

Add: Zernikedreef 12 2333 CL Leiden The Netherlands Tel: (31) 71-524-4044

Technological expertise: DD, PS, DC, PIS, PPAT, P/PS Principal products/instrumentation: Vaccines; biomaterials. Main products/instrumentation under R&D: Biodegradable polymers, lipsomes, peptide nucleic acids, peptidoglycan polymer, protein drugs. Sealed and granted patents: Preparation of microspheres, biodegradable polymers.

2066

OCULEX PHARMACEUTICALS

Add: 639 N. Pastoria Ave. Sunnyvale, CA 94086 Tel: (408) 481-0424 Fax: (408) 481-0662 E-mail: [email protected] President/CEO: Jerry Gin, Ph.D. Research director: Dr. Vernon Wong Subsidiary of Allergan. R&D expertise: Research and manufacture of ophthalmic drug delivery; focus on intraocular diseases. Technological expertise: DD Main products/instrumentation under R&D: Anti-inflammatory drug, Phase III/IV, ophthalmic cream, ophthalmic ointment, ophthalmic suspension, ophthalmic drug for intraocular diseases. Subsidiary bodies: Oculex, Asia — Singapore.

Fax: (31) 71-524-4043 E-mail: [email protected]

2067

O.E.M. CONCEPTS, INC.

Web site: www.octoplus.nl President: Dr. J. J. M. Holthuis Research director: Prof. Dr. D.LA. Crommelin R&D expertise: Research of formulation development pharmaceuticals including proteins, peptides and nucleotides.

Add: 1889 Route 9, Unit 96 Toms River, NJ 08755 Tel: (877) 341-3570 Fax: (732) 286-3173 E-mail: [email protected]

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2069

641

OIL TECHNICS, LTD.

President: Robert W. Minarchi Research director: Brent Dorval, Ph.D. R&D expertise: Bioprocess engineering research; manufacturing of monoclonal/polyclonal antibodies related antigens and conjugates for diagnostic research and manufacturing. Technological expertise: P, PA, LP, P/S, AB, MAE Principal products/instrumentation: Contract manufacturing products, reagent, monoclonal antibodies. Main products/instrumentation under R&D: Polyclonal antibodies related antigens.

2068

O.I. ANALYTICAL

Add: P.O. Box 9010 College Station, TX 77842-9010 Tel: (979) 690-1711 Fax: (979) 690-0440 E-mail: [email protected] Web site: www.oico.com. President/CEO: William W. Botts Research director: Rich Simon R&D expertise: Design, development, manufacture/marketing of chemical analysis and life science products. Joint ventures: Value added reseller for HP. R&D collaboration: Small business technology transfer grant from National Institute of Health for Biosensor Development.

Add: Linton Business Park, Gourdon, Aberdeenshire, DD10 0NH, Scotland U.K. Tel: (44) 156-136-1515 Fax: (44) 156-136-1011 E-mail: [email protected] Web site: www.oiltechnics.co.uk President: Susan Main Research director: Tim Howe R&D expertise: Development and manufacture of oil and chemical bioremediation. R&D collaboration: Biochemicals (Pty), South Africa. Key sales market contracts: BARDAW1LL Emirates Specialty, UAE. Technological expertise: CS, E, ET Key license and trade contracts: Eminent BV Holland. Principal products/instrumentation: OT8 oil spill bioremediation liquid, Biogel oil spill bioremediation gel, Bio Tube oil degrading sorbent. Main products/instrumentation under R&D: Novel oil, chemical biorementation.

2070

OLIGOS ETC.

Add: P.O. Box 727 Wilsonville, OR 97070 Tel: (866) 888-2358 Fax: (866) 769-6001

Technological expertise: Q, SMC, CH/S, PMC, P/S, R

E-mail: [email protected]

Principal products/instrumentation: Detectors, sensors, sample preparation automation, analytical instrument.

R&D expertise: Bioprocess engineering research; development of pharmaceuticalgrade custom synthesized oligonucleotides (DNA/RNA) and purification.

Main products/instrumentation under R&D: Biosensor, chemical analyzers. Subsidiary bodies: Alabama.

Web site: www.oligosetc.com

Technological expertise: AB, GA, GT, P/S, SY, DNA/RNA modifications, purification,

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gene construction, chimeras, s-oligos, labeled oligos. Principal products/instrumentation: Custom synthesized oligonucleotides (DNA and RNA) with all modifications, S-oligos, antisense, chimerics, from 50nm up to 1000ths of grams, oligo purification. Specialty chemicals. Main products/instrumentation under R&D: Pharmaceutical-grade custom synthesized oligonucleotides (DNA/RAN). Sealed and granted patents: Methods for production of arrays with modified oligonucleotide and polynucleotide composition. 6,822,151, U.S.; devices for improved wound management.6,627,215, U.S.

Sophisticated computer for control kinetic and spectrophotometric instruments, rapid scanning monochromator. Sealed and granted patents: U.S. patent #5,285,254 (Rapid scanning monochromator with moving intermediate slit).

2072

OLYMPUS AMERICA, INC.

Add: 2 Corporate Center Dr. Melville, NY 11747-3157 Tel: (516) 844-5000 Fax: (516) 844-5262 Web site: www.olympusamerica.com President/CEO: Ken Fujii

2071

OLIS: ON-LINE INSTRUMENT SYSTEMS, INC.

Add: 130 Conway Dr., Suites A & B Bogart, GA 30622-1724 Tel: (706) 353-6547 Fax: (706) 353-1972 E-mail: [email protected] Web site: www.olisweb.com. President/CEO: Dr. Richard J. DeSa

Subsidiary of Olympus Optical CO. R&D expertise: R&D of clinical chemistry, blood bank, microscopy, endoscopy/products manufacture. Technological expertise: BME, BS Principal products/instrumentation: Endoscopic equipment, microscopic equipment, clinical laboratory equipment/diagnostic kits. Main products/instrumentation under R&D: Clinical evaluation of drug.

Research director: Dr. Richard J. DeSa R&D expertise: R&D/manufacture of sophisticated computer for control kinetic and spectrophotometric instruments, the patented RSM, part of the most novel. Technological expertise: CC, CH/S, COC, BME Principal products/instrumentation: OLIS RSM Rapid-scanning Spectrophotometer (absorbance, fluorescence, stopped-flow; CD, and UV/VIs), OLIS Spectrometer modernizations; OLIS U.S.A. Stopped-Flow, Short pathlength titration accessory. Main products/instrumentation under R&D: OLIS multi-syringe stopped-flow, Phase II;

2073

OLYMPUS OPTICAL CO. (EUROPA) GMBH

Add: Wendenstr asse 14-18 Hamburg 20097 Germany Tel: (49) 40-237-730 Fax: (49) 40-237-734-105 Web site: www.olympus.de President: Werner Teuffel Subsidiary of Olympus Optical Ltd. R&D expertise: Development and manufacture of optical instruments. Technological expertise: BME, AMS

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Principal products/instrumentation: Microscope and Image Analysis and Archiving Systems.

Principal products/instrumentation: 100,000 process measurement and control products, contract manufacturing instrumentation.

Main products/instrumentation under R&D: Optical sectioning microscopy.

Main products/instrumentation under R&D: Measurements equipment for drug components.

2074

OMEGA BIOLOGICALS, INC.

2076

OMEGADYNE, INC.

Add: 910 Technology Blvd. Bozeman, MT 59718

Add: 149 Stelzer Ct. Sunbury, OH 43074

Tel: (406) 586-3790

Fax: (740) 965-9438

Fax: (406) 586-3792.

E-mail: [email protected]

E-mail: [email protected]

Web site: www.omegadyne.com

Web site: www.omegabiologicals.com

R&D expertise: Development and production of sensors for firms in different industries including biotechnology.

President/CEO: Michael J. Halat, Ph.D. R&D expertise: Research of protein chemistry; related novel products manufacture. Technological expertise: F, P/S, C/TC, H/CF, AB Principal products/instrumentation: Heteroblock® — a protein additive which can eliminate interference caused by Heterophilic antibodies in two-site sandwich immunoassays. Biologicals, diagnostics, reagents. Main products/instrumentation under R&D: Protein chemistry synthesis.

2075

OMEGA, COM

Tel: (740) 965-9340

Technological expertise: BME, BTS Principal products/instrumentation: Pressure transducers, load cells, and associated instruments bioremediation, biomaterials, biosensors. Main products/instrumentation under R&D: Sensors for firms in different industries including biotechnology.

2077

OMEGA ENGINEERING, INC.

Add: One Omega Drive Stamford, CT 06907 Tel: (203) 359-1666

Add: One Omega Dr. Stamford, CT 06907

Fax: (203) 359-7706

Tel: (203) 359-1660

E-mail: [email protected]

Fax: (203) 359-7700

Web site: www.omega.com

E-mail: [email protected]

President: B. R. Hollander

Web site: www.omega.com R&D expertise: Development and production of measurement equipment

R&D expertise: Development and production of instrumentation for a wide variety of industries for measurement and control of temperature, pressure, flow, humidity, weight, liquid level, etc.

Technological expertise: BME

Technological expertise: BME, CH/S, BTS

President: B.R. Hollander

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Principal products/instrumentation: Sensors, recorders, controllers, meters, calibrators and associated computer hardware and software. Main products/instrumentation under R&D: Instruments for a wide variety of drugs/industries for measurement/control of temperature, pressure, etc.

Tel: (203) 359-1660 Fax: (203) 359-7700 E-mail: [email protected] Web site: www.vanzetti.com R&D expertise: Research and production of non-contacting infrared temperature measurement using fiberoptics and line-of-sight sensors. Technological expertise: BME

2078

OMEGA OPTICAL, INC.

Add: Delta Campus 21 Omega Drive Brattleboro, VT 05301 Tel: (802) 254-2690 Fax: (802) 254-3937 E-mail: [email protected] Web site: www.omegafilters.com President: Robert L Johnson, Ph.D.

Principal products/instrumentation: Remote temperature sensors and associated instrumentation, natural products, organ transplants/ culture, reagents, vaccines, biomaterials, biosensors, contract research/clinical trial products. Main products/instrumentation under R&D: Non-contacting infrared temperature measurement devices using fiberoptics and line-ofsight sensors.

Research director: Steven Morin, Ph.D. R&D expertise: Research and production of optical interference filters for analytical and clinical instrumentation as well as fluorescence microscopy.

2080

OMICRON BIOCHEMICALS, INC.

Technological expertise: Q, PA, COC, HTDS, PMC.

Add: 115 South Hill Street, South Bend, Indiana 46617-2701

Principal products/instrumentation: Omega® optical filters for fluorescence microscopy; VIVID™ optical filters for fluorescence microscopy; Alpha™ Filter Series, optical filters for Fluorescence & Raman applications; contract manufacturing products, diagnostics, instrumentation products.

Tel: (574) 287-6910

Main products/instrumentation under R&D: Optical interference filters for analytical and clinical instruments.

R&D expertise: Development, design and manufacture/marketing of stable isotopicallylabeled carbohydrates and their derivatives for biomedical applications.

Sealed and granted patents: U.S. patent on optical coatings for color enhancement.

Fax: (574) 287-7165 E-mail: omicron@ omicronbio.com Web site: www.omicronbio.com President/CEO: Anthony S. Serianni Research director: Shikai Zhao

Joint ventures: Cambridge Isotope Laboratories; manufacture of D-[1-13C] glucose.

OMEGA-VANZETTI, INC.

Key sales market contracts: Cambridge Isotope Laboratories; sale of D-[1-13C] glucose.

Add: P.O. Box 4047 One Omega Drive. Stamford, Connecticut 06907-0047

Technological expertise: CC, E, BA, CB, P/S, SMC, SY

2079

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Principal products/instrumentation: Biologicals, contract manufacturing products, contract research/clinical trial products, instrumentation, pharmaceuticals, carbohydrates labeled selectively or uniformly with 2H.13C and/or 17,180. Main products/instrumentation under R&D: Labeled sugar nucleotides; labeled aminosugars, stable isotopically-labeled carbohydrates.

2081

OMNIFIT, LTD.

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Web site: www.omnigenebioproducts.com President/CEO: Janice Pero R&D expertise: R&D of genetic engineering of B. subtilis and E. coli for the production of vitamins, amino acids, enzymes and other proteins and fine chemicals; related products manufacture. Key license and trade contracts: Wacker Chemie, Hoffman-L2 Roche, Genecor, and others. Technological expertise: F, RD, GA, BA, G

Add: 2 College Park Coldhams Lang Cambridge CB1 3HD U.K. Tel: (44) 1223-416-642 Fax: (44) 1223-416-787 E-Mail: [email protected] Web site: www.omnifit.co.uk

Main products/instrumentation under R&D: Bacillus strains deleted for protease genes, expression/secretion vector for use in Bacillus. Sealed and granted patents: Bacillus strains deleted for protease genes (2 patents). Expression/secretion vectors for use in Bacillus and Streptomyces (5 patents).

President: Mr. C. Summerhayes Research director: Mr. N. Fuller Subsidiary of Halma plc R&D expertise: Development, design and production of fluid handling systems, inert plastic precision machining.

2083

OMNI INTERNATIONAL, INC.

Add: 1000 Williams Drive Suite 1024 Marietta, GA 30066

Technological expertise: F, CB, COC, PIS, P/S, R, PMC, SY

Tel: (770) 421-0058

Principal products/instrumentation: PTEE valves, connectors tubing, columns.

E-mail: [email protected]

Main products/instrumentation under R&D: Fluid handling systems, inert plastic precision devices.

R&D expertise: homogenizer

2082

OMNIGENE BIOPRODOCTS, INC.

Fax: (770) 421-0206 Web site: www.omni-inc.com R&D/manufacture

of

Technological expertise: TE, BA, C/TC, HTDS, G Principal products/instrumentation: Omni Mixer Homogenizer.

Add: 25K Olympia Avenue Woburn, MA 01801

Main products/instrumentation under R&D: Two-stage homogenizer, Omni Tip disposable generator

Tel: (781) 938-1966

Subsidiary bodies: Marietta, GA.

Fax: (781) 938-9256

Sealed and granted patents: Omni Tip disposable generator.

E-Mail: [email protected]

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SELECT X PHARMACEUTICALS, INC.

Add: One Innovation Drive Worcester, MA 01605 Tel: (508) 798-0216 Fax: (508) 798-0217

Technological expertise: PA, HTDS Principal products/instrumentation: 1,100 bioreagents for study of apoptosis, neuroscience, cancer, angiogensis, cell proliferation. Main products/instrumentation under R&D: Assay kits and antibodies for study of cancer, apoptosis, angiogensis, cell proliferation.

E-mail: [email protected] Web site: www.omnipharm.com.

2086

ONCOGENE SCIENCE, INC.

President: Michael G. Chaparian, Ph.D. Research director: Michael G. Chaparian, Ph.D.

Add: 106 Charles Lindbergh Blvd. Uniondale, NY 11553

R&D expertise: R&D/manufacture of enabling technologies for drug discovery and screening/antibiotic resistance.

Tel: (877) 229-3711

Technological expertise: E, F, Q, AF, PG, BI, P/S, RD, GA, C/TC, HTDS, SMC Main products/instrumentation under R&D: ComGene™, Combinatorial Genetics drug discovery platform technology, development; DART, drug and antibiotic resistance technology, development; BEST, Bioelectronic Screening Technology platform, development. Sealed and granted patents: 4 pending.

2085

ONCOGENE RESEARCH PRODUCTS

Add: 650 Albany St. Ste. 200 Boston, MA 02118 10394 Pacific Center Ct. San Diego, CA 92121 Tel: (617) 536-8884 Fax: (617) 536-8844 E-mail: [email protected] President: Mark Zimmerman Research director: Dr. Craig Sorensen Subsidiary of CN Biosciences R&D expertise: R&D/manufacture of assay kits and antibodies for study of cancer, apoptosis, neuroscience and angiogenesis.

Fax: (877) 242-1997 E-mail: [email protected] Web site: www.oncogene.com President/CEO: Gary E. Frashier Research director: J. Gordon Foulkes, Ph.D. R&D expertise: Applied oncogene-related and gene transcription technologies to develop and manufacture novel products for the treatment and diagnosis of cancer. R&D collaboration: Pfizer, Inc., cancer therapeutic products; American Home Products, diabetes, immune system modulators, asthma, osteoporosis; Becton Dickinson, cancer diagnostics; Wyeth Ayerst Research Division; Marion Merill Dow, cardiovascular disease. Technological expertise: C/TC, D-D, RD, H/CF, AB, PPAT Principal products/instrumentation: TransProbe-1® CML assay; p53 ELISA assays/pure antibodies; c-neu (erb-B2) ELISA assay/pure antibodies; TGF-alpha ELISA assay/pure antibodies; transcription factor reagents; cell cycle reagents; immunohistochemistry systems; DNA probes; research reagents for oncogenes and growth factors; RGF R ELISA/pure antibodies; tumor suppresor gene antibodies; research products for breast and colon cancer.

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Main products/instrumentation under R&D: TGF-beta-3 for chemoprotection and wound healing, preclinical; inhibitors of oncogeneencoded proteins: ras oncogene inhibitors and neu oncogene inhibitors; multiple drug resistance inhibitors, preclinical; Anti-oncogene directed therapeutics: p53 anti-oncogene modulators; neu oncogene immunoassay, preclinical; p53 anti-oncogene immunoassay, preclinical; EGFR oncogene immunoassay; ras oncogene immunoassay; signal transduction reagents (antibodies, proteins); oncogenerelated reagents (tumor suppressor genes, ras, ceil cycle), applied oncogene-related and gene transcription technologies to develop/produce novel biodrugs.

Principal products/instrumentation: Cell permeable fluorogenic Caspase-3 substrates: PhiPhilux G2D2, Phi-Philux G1D2, Cathepsin D substrate; Caspase substrates; Hepatitis C and HIV protease.

Subsidiary bodies: 80 Rogers St, Cambridge, MA.

Tel: (617) 868-2399

Sealed and granted patents: 6 pending.

E-mail: [email protected]

Main products/instrumentation under R&D: Other Caspase substrate/inhibitor, preclincial; patented technologies for novel drug delivery. Sealed and granted patents: U.S. patent #5,605,809 and #5,714,342.

2088

ONE CELL SYSTEMS, INC.

Add: 100 Inman St. Cambridge, MA 02139 Fax: (617) 492-7921 Web site: www.onecell.com

2087

ONCOIMMUNIN, INC.

President/CEO: Patricia McGrath Research director: Jan Tmovsky, Ph.D.

Add: 207A Perry Parkway Ste. 6 Gaithersburg, MD 20877 Tel: (301) 987-7881 Fax: (301) 987-7882 E-mail: [email protected] Web site: www.phiphilux.com President: Dr. Beverly Packard Research director: Dr. Beverly Packard R&D expertise: Research of patented technologies for novel drug delivery, novel fluorogenic substrates and inhibitors; development and manufacture of diagnostic and therapeutic products for cancer and viral infection. Key sales market contracts: Medical Biological Laboratories, Co., Ltd.; Alexis Corp.; Calbiochem. Technological expertise: E, DD, D-D, HTDS, PIS, PMC, SMC, SY

R&D expertise: R&D of proprietary technologies to commercialize systems and products for the rapid detection, isolation and analysis of mammalian and bacterial cells for research, bioprocessing and clinical diagnostics; related novel products manufacture. Technological expertise: E, F, BA, C/TC, G, HTDS, H/CF, AF Principal products/instrumentation: CellSysTM 100 Microdrop Maker, CellMix™ 200 Emulsion Matrix, Cell-BioGel Encapsulation Matrix. Main products/instrumentation under R&D: Proprietary technologies to commercialize systems and products for the rapid detection, isolation and analysis of mammalian and bacterial cell, one cell systems technologies. Sealed and granted patents: One Cell Systems’ technologies and products are protected by numerous issued and pending U.S. and

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foreign patents (~2001); Secretions of proteins by encapsulated cells 6,806,058 U.S.

2089

ONTOGEN CORPORATION

Add: 6451 El Camino Real Carlsbad, CA 92009 Tel: (760) 930-0100 Fax: (760) 930-0250 President/CEO: Barry E. Toyonaga Research director: William C. Ripka, Ph.D. R&D expertise: Discovery, design, development and production/marketing of small molecule therapeutics for the treatment of life-threatening diseases. R&D collaboration: Nippon Organon K.K. (Japan); Boehringer Ingelheim (Germany); Novo Nordisk A/S (Denmark); Iowa State University.

President/CEO: Doros Platika, M.D. Research director: Lee Rubin R&D expertise: Development, manufacture and marketing of pharmaceuticals based on hedgehog and other inducing molecules and their mechanisms. R&D collaboration: ArQule, Genzyme Molecular Oncology, Becton Dickinson, Comgenex, Oxford Asymmetry. Key license and trade contracts: Many, including Columbia University, Harvard University, Hebrew University and Salk Institute. Technological expertise: Q, TE, BI, G, HTDS Principal products/instrumentation: Human genome project, organ transplants/culture products, pharmaceuticals gegen virus. Main products/instrumentation under R&D: Biopharmaceuticals based on hedgehog and other inducing molecules and their mechanisms.

Technological expertise: CC, R, SMC, E, SY C/TC, COC, CH/S, DD, HTDS, P/S Main products/instrumentation under R&D: OC 144-093 P-gp Inhibitor to treat multi-drug resistance associated with cancer chemotherapy, preclinical; small molecule therapeutics for the treatment of life-threatening diseases. Sealed and granted patents: Issued: MDR — 5,756,527,1998; PTPase — 5,753,687,1998; iNOS — 5,723,451,1998; MDR — 5,700,826, 1997; OntoBLOCK™ — 5,609,826,1997; 5,770,455,1998; 5,770,157,1998; 5,770,620, 1998; 5,840,721,1998; 5,866,569,1999; 10 pending.

2091

ONYVAX, LTD.

Add: St. Georges Hospital Medical School Cranmer Terrance London SW17 ORE U.K. Tel: (44) 208-682-9494 Fax: (44) 208-682-9495 E-mail: [email protected] Web site: www.onyvax.com President: Barrie S. Haigh Research director: Andrew Sutton R&D expertise: Research and production of cancer vaccines.

2090

ONTOGENY, INC.

Add: 45 Moulton St. Cambridge, MA 02138

R&D collaboration: Institute of Cancer Research.

Fax: (617) 876-0866

Key license and trade contracts: Cancer Research Campaign; University of York; University of Rotterdam.

Web site: www.ontogeny.com

Technological expertise: C/TC, GT, PPAT

Tel: (617) 876-0086

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Main products/instrumentation under R&D: Prostate vaccine, Phase I/II; Coloregal Cancer vaccine, Phase II/III; 105A07 antibody (AntiCoss), Phase II.

2092

ONYX PHAIMACEUTICALS, INC.

Add: 2100 Powell Street Emeryville, CA 94608 Tel: (510) 597-6500 Fax: (510) 597-6600 E-mail: [email protected] Web site: www.onyx-pharm.com President/CEO: Hollings C. Renton Research director: Norman Hardman, Ph.D. R&D expertise: Drug development, production and commercialization. R&D collaboration: Ras Program — Bayer Corporation; Cell Cycle Program — WarnerLambert/Parke-Davis; Inflammation — WarnerLambert/Parke-Davis. Technological expertise: P/S, Q, C/TC, D-D, GA, HTDS, H/CE, PIS, RD Main products/instrumentation under R&D: ONYX-015 for treatment of anticancer, Phase II/ III; guanine nucleotide exchange factor. Sealed and granted patents: Methods and compositions for treating abnormal cell growth related to unwanted guanine nucleotide exchange factor activity. 6,340,575, U.S.; Selective killing and diagnosis of p53+ neoplastic 6,296,845, U.S.

2093

OPEN SOFTWARE SOLUTIONS, INC.

Add: 282 County St., Ste. 555 Attleboro, MA 02703 Tel: (508) 880-3650 Fax: (508) 880-0562

649

E-mail: [email protected] President/CEO: Gary R. Arnold Research director: Gerald Ahem R&D expertise: R&D of biopharmaceutical batch recipe information, management systems for pilot and production, facilities, validated systems, consulting and support for all requirements. Joint ventures: ISPE PDA, FDA, BIO, MBC. Key sales market contracts: Lotus Business Partner, Microsoft Developer Program Hewlett-Packard, Digital Equipment Corp., IBM, and Oracle Business Partners. Technological expertise: CH/S, BTS, BME Principal products/instrumentation: Prophecy Software®, Real-Time Data Warehousing™, Batch Information Management System™. Main products/instrumentation under R&D: Biopharmaceutical systems for pilot and production, validated systems.

2094

OPEXA THERAPEUTICS INC

Add: 6900 Dumbarton Cir., Fremont, CA 94555-3651 Tel: (650) 482-2000 President/CEO: John Vuko R&D expertise: Discovery, research, development and manufacture of drug products for the treatment of gastrointestinal diseases. Technological expertise: F, PA, D-D, P/S, BA, C/TC, DD Main products/instrumentation under R&D: The Phase IIb TERMS study. The study will evaluate the safety and efficacy of Tovaxin in subjects with clinically isolated syndrome or relapsing/remitting multiple sclerosis. Patients will be treated for 52 weeks and will undergo safety and efficacy assessments using the primary criterion of gadolinium-enhancing

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lesions and the secondary criterion of annualized relapse rate. Sealed and granted patents: 15 patents in immunotherapeutics.

2095

OPTEK-DANULAT, INC.

Add: 279 S. 17th Ave. Suite #10 West Bend, WI 53095

systems with CCTV capability, Fixed, Dual and Zooming CCTV adapters, Zooming accessories for compound microscopes, customized microscope-type optical systems, optical systems for emission microscopes. Main products/instrumentation under R&D: New custom optical systems.

2097

Tel: (262) 437-3600

OPTICAL TECHNOLOGY DEVICES, INC.

Fax: (262) 437-3699

Add: 99 Wall St Valhalla, NY, 10595-1452

E-mail: [email protected]

Tel: (914) 592-1900

Web site: www.optek.com

Fax: (914) 592-5284

President: Juergen Danulat

President: Felix A. Brogna

Research director: Rik Meyer

Research director: Felix A. Brogna

R&D expertise: Development, manufacturing and marketing of process photometry

R&D expertise: Fluorescent detectorsresearch, design and manufacture.

Technological expertise: B, M, P/S, BA, PMC

Technological expertise: BME, FL, HC

Principal products/instrumentation: In-line pilot and process scale photometry; UV-VISNIR; Absorption photometers and scatteredlight turbidimeters; Product spectral analysis to aide in application assessment.

Principal products/instrumentation: Fluorometers, HPLC Fluorescent Detectors, Spectrofluorometers. Main products/instrumentation under R&D: Fluorescent substrate labelled immunoassay.

Main products/instrumentation under R&D: Process analysis photometry, process analyzer. 2098 2096

OPTEM INTERNATIONAL

Add: 78 Schuyler Baldwin Dr. Fairport, NY 14450 Tel: (716) 223-2372 Fax: (716) 223-3413 E-mail: [email protected] President/CEO: Wiliard Hunter R&D expertise: Research, development and manufacture of custom optical systems. Technological expertise: PMC Principal products/instrumentation: Contract manufacturing products, zoom optical

OPTOFLOW AS

Add: P.O. Box 56 Bogerud 5881Bergen Norway Tel: (47) 2262-8152 Fax: (47) 2262-7275 President: Oddbjom Gjelsnes Research director: Oystein W. Ronning, Ph.D. R&D expertise: Biotechnology, cell and tissue culture research, related novel products manufacture. Key license and trade contracts: Molecular Probes Technological expertise: PMC, CH/S, C/TC

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Principal products/instrumentation: Microcyte™, vaccines, reagents.

Fax: (617) 494-1741

Main products/instrumentation under R&D: Cell and tissue culture, novel biotechnology medicines.

Research director: Thomas P. Monath, M.D.

Sealed and granted patents: #5,739,902.

2099

ORACHROM, INC.

Add: 10-B Henshaw St Woburn, MA 01801 Tel: (781) 932-0151 Fax: (781) 932-0787 E-mail: [email protected] Web site: www.orachrom.com President/CEO: Hossein K. Hodjat, Ph.D. Research director: Richard H. Seder, M.D., MPH. R&D expertise: Research and manufacture of polymeric stationary phases for high speed, high performance liquid chromatography and for the purification of biopharmaceuticals. R&D collaboration: NTH. Technological expertise: P/S, BA, E, ET Principal products/instrumentation: Reversed phase polymeric, Styros 1 and 2; Strong Anion Exchanger, Weak Anion Exchanger, Immobilized enzyme, DEAE Polymeric, HIC Polymer. Main products/instrumentation under R&D: HIC, Affinity and the full range of high performance stationary phases for bioseparation, beta site testing, polymeric stationary phases for high speed, high performance liquid chromatography/purification of biopharmaceuticals.

2100

ORAVAX, INC.

Add: 38 Sidney St Cambridge, MA 02139 Tel: (617) 494-1339

President/CEO: Lance K. Gordon, Ph.D. R&D expertise: Research of drug discovery, development of vaccines and antibody products to prevent or treat human infectious diseases. Joint ventures: Pasteur Merieux Serums and Vaccines S.A. — to develop, manufacture and market vaccines to prevent and treat infections from Helicobacter pylori bacteria. Key sales market contracts: CSL Limited — exclusive distributor of HNK20 antibody nosedrop in Australia, New Zealand, Indonesia and Papua New Guinea; Evans Medical Limited (marketing and distribution agreement) — Arilvax yellow fever vaccine. Key license and trade contracts: Vanderbilt University under which it acquired exclusive, worldwide rights to the CagA gene, an integral component of Helicobacter pylori, the bacterium which causes most peptic ulcers and has been linked to the development of stomach cancer; St Louis University — Chimeric Flavivirus vaccines. Technological expertise: DD, D-D, AB Main products/instrumentation under R&D: Oral vaccines intended to control human infection with Heliocabacter pylori, monoclonal IgA antibodies, HNK20 antibody nosedrop for respiratory syncytial virus, Phase III/IV; UreAB oral vaccine for the prevention and treatment of peptic ulcers caused by Helicobacter pylori, Phase III; C. difficile vaccine for antibiotic-associated diarrhea, Phase II/III; Japanese Encephalitis vaccine for potentially fatal neurotropic viral infection, endemic in Japan, China and other countries of the Pacific Rim, preclinical studies; Arilvax yellow fever vaccine, Phase III/IV; ChimeriVax™ vaccines against flavivirus. Subsidiary bodies: Manufacturing facility in Canton, MA, U.S.A.

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Sealed and granted patents: U.S. Patent No. 5,538,729-covering oral vaccines intended to control human infection with Heliocobacter pylori (H. pylori); U.S. patent No. 5,534,411covering the use of monoclonal IgA antibody against respiratory syncytial virus for the development of the most advanced clinical product candidate, HNK20.

2101

ORBISPHERE

Add: Hach Company P.O. Box 389 Loveland, Colorado 80539 Tel: (970) 227-4224

Technological expertise: P/S, C/TC, PMC, CH/S, R, BME, AU Principal products/instrumentation: Automation and robotics devices, tactile sensors, rotation sensors, gas jet generators, plant growth chambers. Main products/instrumentation under R&D: Plant growth systems for space flight, plant agglutinin, plant growth systems for aerospace and terrestrial application.

2103

ORCHID CELLMARK, INC.

Fax: (970) 669-2932

Add: 4390 U.S. Route One Princeton, NJ 08540

Web site: www.orbisphere.com

Tel: (609) 750-2200

President: Yves Ducommun

Fax: (609) 750-6405

Research director: Jorge Core

E-mail: [email protected]

Subsidiary of Hach Lange.

Web site: www.orchid.com

R&D expertise: R&D/manufacture of gas measuring instrumentation.

President/CEO: Dale R. Pfost, Ph.D.

Technological expertise: PMC, BME

R&D expertise: R&D/manufacture of microfluidic systems to revolutionize chemical synthesis and biochemical analysis for drug discovery and diagnostics.

Principal products/instrumentation: Oxygen, carbon dioxide, nitrogen and hydrogen sensors. Main products/instrumentation under R&D: Novel gas measuring instruments.

2102

ORBITAL TECHNOLOGIES CORP. (ORBITEC)

Add: 1212 Fourier Dr. Madison, WI 53717 Tel: (608) 827-5000 Fax: (608) 827-5050 Web site: www.orbitec.com President/CEO: Dr. Eric E. Rice Research director: Dr. Eric E, Rice R&D expertise: R&D of plant growth systems for aerospace and terrestrial applications.

Research director: Michael Boyce-Jacino

R&D collaboration: SmithKline Beecham — combinatorial chemistry system to synthesize and screen hundreds of thousands of potential drugs a year. Key license and trade contracts: Sarnoff Corp. — Orchid has exclusive rights to use Sarnoff-developed technologies for the development of its own microfluidic and miniaturized products. Dynal A.S. — Orchid receives exclusive rights to the use of Dynal’s magnetizable bead technology for uses in its microstructures. Technological expertise: C/TC, COC, GA, HTDS, PG, R, D-D, SMC, SY, DD, DDI Main products/instrumentation under R&D: Chemtel™ chips, consumables and analytical systems to accelerate and improve the

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cost-effectiveness of drug discovery, development and diagnostic processes, technology development, preclinical; microfluidic systems to revolutionize chemical synthesis and biochemical analysis for drug discovery.

Tel: (781) 575-0775

Sealed and granted patents: #5,585,069, #5,593,838, #5,603,351, #5,632,876, #5,643,738, #5,681,484, #5,747,169; many pending.

Research director: Nancy Parenteau, Ph.D.

2104

OREAD, INC.

Add: 1501 Wakarusa Dr. Lawrence, KS 66047 Tel: (785) 749-0034 Fax: (785) 832-4395 President: W. David Kimbrell Research director: Dr. David Johnston R&D expertise: Bioprocess engineering research, contract drug development and manufacturing services. Technological expertise: CC, DD, PIS, P/S, SMC, SY, analytical chemistry, stability, toxicology, radiography, and synthesis research. Principal products/instrumentation: Special chemicals, small molecule organics, natural products. Main products/instrumentation under R&D: Biopress technology, contract drug products. Subsidiary bodies: Oread — Pharmaceutical/ Toxicology Services, 400 Farmington Ave., Farmington, CT 06032, (860) 674-6300; Oread — Pharmaceutical Manufacturing, 340IP Hillview Ave., Palo Alto, CA 94304, (650) 813-4300; Blis-Tech — Pharmaceutical Packaging, 80 Little Falls Rd., Fairfield, NJ 07004, Tel: (973) 575-5958; Oread — formerly Proceutics, 150 Technology Pkwy., Norcross, GA 30092, Tel: (770)263-1100.

2105

ORGANOGENESIS, INC.

Add: 150 Dan Rd. Canton, MA 02021

Fax: (781) 575-0440 Web site: www.organogenesis.com President: David Rovee, Ph.D. R&D expertise: R&D/manufacture of therapeutic product, includes living tissue replacements, cell-based organ assist devices and guided tissue regeneration scaffolds. R&D collaboration: Brigham and Women’s Hospital — oral mucosal tissue; Children’s Hospital (Boston) — graft acceptance; Harvard Medical School — extracellular matrix-related therapeutics; Massachusetts General Hospital — liver assist device. Key sales market contracts: Novartis Pharmaceuticals AG granted worldwide marketing. Rights to Apligraf™. Key license and trade contracts: Toyobo Co. Ltd. — license agreement for Testskin and related in vitro testing products in Japan. Technological expertise: C/TC, BME Principal products/instrumentation: Apligraf™ for venousulcers. Main products/instrumentation under R&D: Apligraf™ — venous ulcers, R&D, preclinical; Apligraf™, dermatological surgery, R&D, preclinical; Apligraf™ — burns, R&D, preclinical; Apligraf™ — donor site wounds, R&D, preclinical; Apligraf™- diabetic ulcers, R&D, preclinical; Apligraf™ — decubitus ulcers, R&D, preclinical; GRAFTPATCH — general surgical procedures for reinforcement of soft tissue; Small diameter graft — peripheral vascular procedures; Coronary artery bypass, R&D, preclinical; Dimensional tissue filler — urinary incontinence, R&D, preclinical; Liver assist device — liver disease, R&D, preclinical; Pancreatic islet cell — diabetes, R&D; Surgical repair and reconstruction products, R&D, preclinical; Vascular support product — Stentwrap applications, R&D, preclinical;

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methods of cell culture, vivo induction for enhanced function of isolated hepatosytes.

Web site: www.orgenics.com

Sealed and granted patents: General areas: tissue source, methods of preparation, methods of cell culture, sterilized technique, manufacturing, packaging and storage; in vivo induction for enhanced function of isolated hepatocytes. 6,699,716, U.S.; Vivo induction for enhanced function of isolated hepatocytes. 6,394,812, U.S.

Research director: Dr. Ouriel Paktor

2106

ORGANOTECHNIE S.A.S

Add: 27 av. Jean Mermoz La Courneuve 93120 France Tel: (33) 149-928-750 Fax: (33) 149-928-751 E-mail: [email protected]

President/CEO: Emanual Hart Subsidiary of SELFCARE INC. R&D expertise: Development, manufacture and marketing of diagnostics products. Technological expertise: BI, GA, G, RD, DK Principal products/instrumentation: Immuno Comb (diagnostic tool for diagnosis of major infectious diseases including AIDS, hepatitis A, B, C), TORCH, H. Pylori Main products/instrumentation under R&D: Diagnostic tool for the detection of PCR products, preclinical phase; Rapid diagnosis device, preclinical; Genecoms, rapid detection of per amplified HIV RNA chlaryoia DNA, new diagnostic drugs, diagnostic enzymes, diagnostic kits.

Web site: www.organotechnie.com President/CEO: Bruno Chabrel

2108

ORIGENE TECHNOLOGIES, INC.

Research director: Catherine Duval R&D expertise: Development and manufacture of drug industrial fermentation media.

Add: 9620 Medical Center Dr., Suite 200 Rockville, MD 20850

Technological expertise: E, F, P/S, C/TC, SY, ET, protein hydrolysates and peptones for industrial microbiology and fermentation.

Tel: (301) 340-3188

Principal products/instrumentation: Specialty chemicals, peptones and protein hydrolysates.

Web site: www.origene.com.

Main products/instrumentation under R&D: New peptones for fermentation industry, new industrial fermentation media.

2107

ORGENICS, LTD.

Add: P. O. Box 360 North Industrial Zone Yavne 70650 Israel Tel: (972) 8-942-9201 Fax: (972) 8-943-8758 E-mail: [email protected]

Fax: (301) 340-9254 E-mail: [email protected] CEO: Gilbert Jay, Ph.D. R&D expertise: Development and manufacture of molecular biology research reagents. Technological expertise: V, N, GN, RD, BI, GA, G Principal products/instrumentation: RapidScreen cDNA Library Panels, Rapid-Scan Gene Expression Panels, Sure-RACE MultiTissue RACE Panels, Longest-clone screening service, Smart Array microarrays; cDNA Clones in GFP Vector: TrueORF cDNA clones, are GFP (green fluorescence protein) vectors, enabling easy transfection monitoring and protein expression. With this launch, over

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25,000 human ORF (open reading frame) clones and 12,000 mouse ORF clones can be ordered in pCMV-tGFP vector. With comprehensive TrueORF cDNA clones, researchers can now coexpress a specific gene with GFP to monitor protein expression level, detect exact cellular location, and study proteinprotein interaction. As a leading full-length cDNA clone provider, OriGene is committed to providing expanded utilities for these clones in life science research and drug discovery, 2009;cDNA Clones in GFP Vector: TrueORF cDNA clones, are GFP (green fluorescence protein) vectors, enabling easy transfection monitoring and protein expression, 2009. Main products/instrumentation under R&D: Novel molecular biology research reagents.

2109

ORION RESEARCH, INC.

Add: 500 Cummings Center Beverly, MA 01915 Tel: (978) 922-4400 Fax: (978) 922-3932 President: James Barbookles Research director: Steve West Subsidiary of Thermedics Detection Inc. R&D expertise: R&D and manufacture of biotechnological products. Technological expertise: CC, F, P, COC, CH/S, DD, PMC, R, SMC Principal products/instrumentation: Vaccines, biologicals, biomaterials, bioremediation, biosensors, contract manufacturing products, cosmetics, detergents, diagnostics, human genome project, natural products, pesticides, pharmaceuticals, plastics, reagents, vaccines, veterinary products. Main products/instrumentation under R&D: New biotech diagnostic/therapeutic products.

2110

655

ORPEGEN PHARMA GMBH

Add: Gesellschaft für biotechnologische Forschung, Entwicklung & Produktion m.b.H Czerny-Ring 22 69115 Heidelberg Germany Tel: (49) 6221-726-7700 Fax: (49) 6221-726-7710 E-mail: [email protected] Web site: www.orpegen.com President/CEO: Dr. Christian Birr Research director: Dr. Wemer Hirt R&D expertise: R&D/manufacture of peptides and peptide instrumentation; production analysis of amino acid derivatives from kg to tons (tert butyl esters and ethers, Fmoc-, Boc Ddz-, Z-); development and production of pharma peptides from mg to kg including GMP standards and FDA approval (antigenic determinants, hormones, immunoregulatory fragments, etc.); development and production of recombinant proteins by cell culture or fermentation including GMP-standards and protein refolding; development and production of diagnostic test kits for flow cytometry (Phagotest-R; Bursttest (Phagoburst-R), LDL Receptor Test, NK-Test, NK-Test and BASOTest), contract research and services in many areas of the biotechnology field. Technological expertise: RD, F, P/S, BA, GA, H/CF, C/TC, SY, D-D, GT, LP, Q, E Principal products/instrumentation: Amino acid derivatives (tort butyl ester and ethers, Fmoc, Boc, Ddz, Z); peptide hormones, irnmunoregulatory peptides, antigenic determinants, HYCRAM™ polymer support, HYCRAMTM linked amino acid derivatives (monomeric), Phagotest™, Phagoburst™ diagnostic kits, HD SilTM, HD GELT™, recombinant proteins. Main products/instrumentation under R&D: Pharmaceutical glycoprotein in clinical Phase III/IV, hyaluronic acid (preclinical),

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peptide hormones, monoclonal antibodies for diagnostics, diagnostic test kits, peptide instruments.

2111

R&D expertise: R&D of hematology/oncology and immunotherapy, related novel products manufacture. R&D collaboration: Institute.

ORSTOM

Add: 911, Ave Agnopolis, B. P. 5045 MontpellierCedex 34032 France Tel: (33) 46-761-7579 Fax: (33) 46-752-9505 E-mail: [email protected] Web site: www.orstom.fr President: Hubert Fournier Research director: Dr. Bernard Marin R&D expertise: Any biopharmaceutical and pharmaceutical research with the development of the countries of the south. Technological expertise: E, F, PA, Q, TE, T, AF, AB, H/CF, PIS, PMC, BI, BA, C/TC, CH/S, D-D,GA, GT, P/S, RD, SMC, SY Principal products/instrumentation: Agriculture, biologicals, biomaterials, bioremediation, biosensors, contract research/clinical trial products., cosmetics, detergents, diagnostics, human genome project, natural products, organ transplants/culture, pesticides, pharmaceuticals, vaccines, veterinary products. Main products/instrumentation under R&D: New biopharmaceuticals.

Scripps

Research

Key sales market contracts: Amgen Inc — (recombinant human erythropoietin) Technological expertise: H/CF, RD, RPP Principal products/instrumentation: Procrit™/(Epoetin alfa), recombinant human erythropoietin (rEPO); treatment of anemia associated with chronic renal failure, including patients on dialysis and not on dialysis, and anemia in retrovir-treated HIV-infected patients; treatment of anemia caused by chemotherapy in patients with non-myeloid malignancies; prevention of anemia associated with surgical blood loss, autologous blood donation adjuvant; anemia in children with chronic renal failure. Orthoclone OKT3® (muromomab-CD3). Main products/instrumentation under R&D: Orthoclone, OKT4A for prevention of organs transplant rejection, Phase II/III, 2008; Procrit®, perisurgical applications (Phase III/IV).

2113

CAPSTONE THERAPEUTICS

Add: 1275 West Washington Tempe, AZ 85281 Tel: (602) 286-5520

2112

E-mail: [email protected]

ORTHO BIOTECH, INC.

Web site: www.capstonethx.com. Add: 800 PA19044

Ridgeview

Drive

Horsham,

Tel: (908) 227-5624

President/CEO: Thomas Trotter Research director: Frank P. Magee, D.V.M.

President: Dennis N. Longstreet

R&D expertise: Development and design of biophysical technologies for stimulation of tissue repair and tissue engineering, continuous passive motion devices.

Research director: Loretta Itri, M.D.

Key sales market contracts: Sanofi

Fax: (908) 526-4997 Web site: www.orthobiotech.com

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Technological expertise: P/S, H/CF, C/TC, CH/S, SY, DD Principal products/instrumentation: Bone Growth Stimulator, Passive Motion Device, Hyalgan. Main products/instrumentation under R&D: Biophysical technologies for stimulation of tissue repair and tissue engineering, methods of therapy with thrombin-derived peptides. Sealed and granted patents: Methods of therapy with thrombin-derived peptides. 7,034,001, U.S.

2114

OSI PHARMACEUTICALS, INC.

Add: 41 Pinelawn Road Melville, NY 11747

657

Phase III; Anti-oncogene, preclinical; Antiangiogensis, preclinical; Cosmeceuticals, preclinical; cp-358,774 (cellular therapy) for cancer, Phase II/III, CD-609,754, for cancer, Phase I/II. Subsidiary bodies: Birmingham, U.K.; Tarrytown, NY; Cambridge, MA; Durham, NC. Sealed and granted patents: Methods of transcription modulating gene expression. #5,776,502; Methods of discovering chemicals capable of function as gene expression of modulators. #5,665,543; Methods of preparing compositions comprising chemicals capable of transcriptional modulators. #6,589,733, U.S.; Conformationally constrained peptidomimetics as beta-turn templates and modulators of SH3 domains. #6,638,941, U.S.; Liposomal camptothecin formulations. #6,740,335, U.S.

Tel: (631) 962-2000 Fax: (631) 752-3880

2115

ORTHOLOGIC CORP.

E-mail: [email protected] Web site: www.osip.com President/CEO: Colin Goddard, Ph.D. Research director: Arthur M. Bruskin, Ph.D. R&D expertise: Biotechnology medicines and other drug discovery and development with a substantial pipeline of product opportunities for commercialization with the pharmaceuticals industry. Key license and trade contracts: Pharmacia & Upjohn — OSI’s Gene Transcription Patent Estate Aurora Bioscience — OSI’s Gene Transcription Patent Estate. Technological expertise: COC, HTDS, R, SMC Principal products/instrumentation: Tarceva (Erlotinib Hydrochloride), treatment of locally advanced or metastatic Non Small-Cell Lung Cancer (NSCLC) after failure of at least one prior chemotherapy regimen, 2008. Main products/instrumentation under R&D: TGF-beta3(growth factor), treatment for anti-scarring, Phase II, 2008; Anti-oncogene,

Add: 1275 W. Washington, Tempe, AZ 85281. Tel: (602) 286-5520 R&D expertise: Bioprocess engineering research; development and manufacture of biotech drugs. Technological expertise: DD, D-D Principal products/instrumentation: Biopharmaceuticals, specialty chemicals, contract R&D products. Main products/instrumentation under R&D: Phase I, randomized, placebo-controlled, doseescalation, sing-center clinical trial of AZX100 in dermal/hypertrophic scarring. The safety and tolerability of escalating doses of AZX100 will be evaluated in approximately 30 aminoacid peptide, one of a new class of compounds in the field of smooth muscle relaxation and fibrosis.

2116

OSMOTEK, LTD.

Add: P.O. Box 550 Rehovot Norfolk 550 Israel

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Tel: (972) 8-931-5556 Fax: (972) 8-931-5556

Sealed and granted patents: 17 patents on variety of compounds.

E-mail: [email protected] CEO: Dr. Gerald Tanny R&D expertise: Equipment design/manufacture for plant tissue culture. Key sales market contracts: Sigma Chemical, Life Technologies, Carolina Biological Supply.

2118

OSTEX INTERNATIONAL, INC.

Add: 2203 Airport Way South Ste. 400 Seattle, WA 98134 Tel: (206) 292-8082 Fax: (206) 292-8625

Technological expertise: C/TC, BME, ERT

E-mail: [email protected]

Principal products/instrumentation: LifeReactor bioreactor; Vented TC vessels; VitroCut; Rafts and floats for liquid T.C.

Web site: www.ostex.com

Main products/instrumentation under R&D: Mammalian culture support, Macrocarrier, equipment for plant tissue culture. Sealed and granted patents: U.S. patent on LifeRaft.

2117

OSTEOARTHRITIS SCIENCES, INC.

Add: One Kendall Square Building 200 Cambridge MA 02139 Tel: (617) 252-6886 Fax: (617) 252-9096 President/CEO: Thomas R. Sharpe, Ph.D. Research director: Thomas R. Sharpe, Ph.D. R&D expertise: Development and manufacture of therapeutic agents to treat osteoarthritis and related connective tissue disorders.

President: Thomas A. Bologna Research director: Dan Clemens/David Eyre Subsidiary of Inverness Medical Innovations, Inc. R&D expertise: Research, development, manufacturing and marketing of generic diagnostics and therapeutics for skeletal and connective tissue diseases. R&D collaboration: Mochida Pharmaceutical, Johnson & Johnson Clinical Diagnostics, Metrika Laboratories. Key sales market contracts: Wyeth-Ayerst, P&G. Key license and trade contracts: Mochida Pharmaceutical, Johnson & Johnson Clinical Diagnostics, Physician Sales and Service. Technological expertise: PA, PMC, SMC, SY, C/TC, H/CF, PIS

Technological expertise: E, PA, Q, C/TC, DD, D-D, SMC, SY

Principal products/instrumentation: Osteomark Assay™, OSTEOMARK® NTx Urine, OSTEOMARK® NTx Serum, Osteomark NTX Point of Care Device.

Main products/instrumentation under R&D: Topical anti-inflammatory-OAS 1000, Phase II; therapeutic agents to treat osteoarthritis and related connective tissue disorders.

Main products/instrumentation under R&D: Type II collagen assay, preclinical; generic diagnostics and therapeutics for skeletal and connective tissue diseases.

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Sealed and granted patents: Type I collagen NTx and CTx; Type II collagen NTx and CTx.

2119

OSWEL RESEARCH PRODUCTS, LTD.

Add: Lab 5005, Medical and Biological Sciences Building, University of Southampton, Boldrewood

659

Technological expertise: F, Q, T, RD, P/S, H/CF, C/TC Principal products/instrumentation: Ocupress®, opthalmic solution 1% for treatment of glaucoma. Main products/instrumentation under R&D: R&D on monoclonal antibody against inflammatory disease, preclinical; other novel biopharmaceuticals.

Tel: (230) 8059-2984. Fax: (230) 8059-2982 E-mail: [email protected]; info.uk@ oswel.com

2121

OVELLE PHARMACEUTICALS

President: J. P. Delwart

Add: Industrial Estate Coes Road, Dundalk, Co. Louth, Ireland

Research director: Prof. T. Brown

Tel: (353) 42-933-2304

Subsidiary of Eurogentec BEL.

Fax: (353) 42-935-1884

R&D expertise: R&D/manufacture of biotechnology medicines.

CEO: Sean R. Gardiner

Key sales market contracts: Dider Allaer.

Research director: Alan Breen, M.Sc.

Key license and trade contracts: Dider Allaer.

R&D expertise: Dermatology research and related products manufacture.

Technological expertise: Q, SMC, AB, COC Principal products/instrumentation: Synthetic oligonucleotides, DNA and RNA standard and modified, DNA sequencing. Main products/instrumentation under R&D: Other novel biotechnology medicines.

2120

OTSUKA AMERICAN PHARMACEUTICAL, INC.

Add: 2440 Research Blvd. Rockville, MD 20850 Tel: (301) 990-0030

Web site: www.ovelle.ie

R&D collaboration: Several universities. Key sales market contracts: Goldshield Health, U.K.; Weko Phar., Germany; Research Ethicals, South Africa. Key license and trade contracts: Cuxson Gerrard, U.K. Technological expertise: AF Principal products/instrumentation: Imuderm, Imfaderm, Emulave, Jleo Clems, Emu Clem’s. Main products/instrumentation under R&D: Dermics.

Fax: (301) 212-8647 Web site: www.otsuka-us.com

2122

OWL SEPARATION SYSTEMS

President: Tetsumi Sato Research director: Yasuo Iriye R&D expertise: Pharmaceutical/biopharmaceutical R&D and marketing, primarily for ethical drugs; basic research in various areas.

Add: 55 Heritage Ave. Portsmouth, NH 038015661 Tel: (603) 559-9297 Web site: www.owlsci.com

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E-mail: [email protected]

Tel: (49) 40-5608-1020

President: Don McGlory

Fax: (49) 40-5608-1222

Research director: John King, Ph.D.

E-mail: [email protected]

Subsidiary of Erie Smith.

Web site: www.oai.co.uk

R&D expertise: Design, development, manufacture and supply of bioresearch products including electrophoresis, radiation safety laboratory apparatus and chemicals.

President: Dr. Edwin Moses

Technological expertise: Q, P/S, GA, BME Principal products/instrumentation: Buffer Puffer™ self-recirculating electrophoresis chambers, Easy-cast™ minigel systems, Joey™ leak-free gel casters, Road Runner™ air-cooled and PenguinTM watercooled doublesided vertical electrophoresis systems, Panther™ DNA sequence electroblotter, mini tank-style electroblotter, MiniCyclerTM thermal controller, gel drying system, Polar BearTM Isothermal Electrophoresis System, Ice-OTherm™ Chiller/Recirculator, Poly-ThermTM Programmable Recirculator, HyrollerTM Hybridization Oven, Burst Pak™ 6% Sequencing Gel, Easy-CasTMt Minigel Systems, PenguinTM and PuffinTM watercooled vertical electrophoresis systems, PantherTM Semidry electroblotters, Minitank and Bandit™ large format tank electroblotter, Aluminum Backed Sequencing System, the OtterTM Sequencing Gel Caster, Electropure Reagents, Electroporation devices and cuvettes, daiichi precast gels and silver stains.

Research director: Dr. Tony Baxter Major partners: Cambres Corp., Astra Chanwood, FMC Corp., Leukosite Inc., LXR Biotechnology Inc., Vanguard Medica Ltd., Vertex Pharmaceuticals Inc., Pfizer. R&D expertise: Chemical R&D services from discovery to manufacture, chemical libraries, custom synthesis, chiral compounds, reference catalogue, route and process development, analytical method development. R&D collaboration: Bayer, Dow Agrosciences, Eastman, Vertex, Organon, ParkeDavis, Ares-Serono. Technological expertise: CC, D-D, COC, SY, SMC Principal products/instrumentation: Biologicals, vaccines, monoclonal antibodies. Main products/instrumentation under R&D: Chiral compounds, chemical libraries, chiral reagents.

2124

OXFORD BIOMEDICAL RESEARCH, INC.

Main products/instrumentation under R&D: Radiation safety laboratory apparatus.

Add: P.O. Box 522 Oxford, MI 48371

Sealed and granted patents: Burst-Pak.

Tel: (248) 852-8815 Fax: (248) 852-4466

2123

OXFORD ASYMMETRY INTERNATIONAL PLC/EVOTEC OAI

Add: 151 Milton Park Abingdon, Oxon 0X14 4SD U.K./Schnackenburgal 114, 22525 Hamburg, Germany

E-mail: [email protected] Web site: www.oxfordbiomed.com President/CEO: Denis Callewaert, Ph.D. Research director: Fazlul Sarkar, Ph.D. R&D expertise: Cancer research and development/manufacture of reagents.

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Technological expertise: E, PA, Q, C/TC, GA, H/CF, PIS, P/S, RD Principal products/instrumentation: P450, prostaglandin syntheses, lipoxygenases, protein kinases. Main products/instrumentation under R&D: Recombinant prostaglandin syntheses, cancer suppressor.

2126

661

OXFORD BIORESEARCH, LTD.

Add: Magdalen Centre 1 Robert Robinson Avenue U.K. Tel: (44) 1865-784-441 Fax: (44) 1865-784-443 E-mail: [email protected] Web site: www.oxfordcryosystems.co.uk President: S. A. Cedeeholm-Williams

2125

OXFORD BIOMEDICA PLC

Add: Medawar Centre, Robert Robinson Av. Oxford Science Park Oxford, Oxon 0X4 4GA U.K. Tel: (44) 186-578-3000 Fax: (44) 186-578-3001 E-mail: [email protected] Web site: www.oxfordbiomedica.co.uk President: Mr. A. G. Goodman Research director: Professor S. M. Kingsman R&D expertise: R&D of gene therapy, genebased immunotherapy and gene discovery. Products manufacture. Key license and trade contracts: Oxford University, Sheffield University, Cancer Research Campaign, Boston University. Technological expertise: TE, COC GT, HTDS, PIS, RD, G Main products/instrumentation under R&D: Gene therapy products for solid tumours, Phase II/III and preclinical; Gene therapy products for AIDS, preclinical; gene therapy products for neurodegenerative disease, preclinical; gene-based immunotherapy products, therapeutic genes, R&D. Sealed and granted patents: A range of patents covering vector technology, therapeutic genes, production systems and gene expression control.

Research director: S. A. Cedeeholm-Williams R&D expertise: Biological/medical drugs discovery, related novel products development and manufacture. Technological expertise: E, PA, TE, BS, C/TC, DD, GA, GT, PIS, P/S, RD Principal products/instrumentation: Biologicals, natural products, organ transplants/ culture. Main products/instrumentation under R&D: Thrombolytic-novel chemical; Haemostat, new discovery drugs.

2127

OXFORD GLYCOSCIENCES (U.K.), LTD.

Add: 10 The Quadrant Abingdon Science Park Abingdon, Oxon 0X14 3YS U.K. Tel: (44 ) 123-554-3200 Fax: (44) 123-555-4701 E-mail: [email protected] President: G. Kirk Raab, Chairman Research director: Prof. Raj B. Parekh R&D expertise: Proteomics fundamental and applied research; drug discovery, and glycobiology reagents development, related novel products manufacture. R&D collaboration: Proteome collaborations: University of Oxford — RA and Alzheimer’s;

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Proteome technologies: University of Geneve, University of Washington. Technological expertise: CC, E, F, Q, AF, AB, BI, BME, COC, CH/S, ERT, ET, SMC, SY, BS, C/TC, DD, HTDS, PMC, P/S, R Principal products/instrumentation: Proteome technology — commercial collaborations; glycobiology reagents, enzymes, research kits, analytical services, contract synthesis diagnostics. Main products/instrumentation under R&D: OGT 719, Phase II, to treat primary liver cancer; OGT 918, to treat glycolipid storarge diseases, preclinical. Sealed and granted patents: Various patents including U.S. #4,179,294; U.S.. #5,539,090 and equivalents.

OMIGA, GCG Wisconsin package, SeqLab, SeqWeb, SPSPhrap, SPS SWAT, SPS CrossMatch (all trademarks or registered trademarks). Main products/instrumentation under R&D: Various different software tools to support biotechnology. Drugs, etc. and research. Sealed and granted patents: Various patents pending.

2129

OXIGENE, INC.

Add: 701 Gateway Blvd, Suite 210 South San Francisco, CA 94080 Tel: (650) 635-7000 Fax: (650) 635-7001 E-mail: [email protected]

2128

OXFORD MOLECULAR

Web site: www.oxigene.com President/CEO: Bjorn Nordenvall

Add: 11350 McCormick Rd. Ste. 1100 Hunt Valley, MD 21031-1002 Tel: (408) 879-6300 Fax: (408) 879-6302 E-mail: [email protected] Web site: www.accelrys.com President: Dr. David Jackson Research director: Dr. Kevin Woods Subsidiary of ACCELRYS. R&D expertise: R&D/manufacture of more than 25 different software tools to support pharmaceutical, chemical, biotechnology and academic research. R&D collaboration: Alizyme, Astra, Dainippon, Glaxo Wellcome, ImmunoGen, Mitsubishi Chemical Corp., NeoRx, PolyMASC Pharmaceuticals, Yamanouchi Pharmaceutical Co. Ltd. Technological expertise: Q, SMC, BI, COC, CH/S, D-D, PG Principal products/instrumentation: MacVector, GeneWorks, CAChe, UniChem, TOPKAT, Tsar, RS3 Discovery, RS3 HTS, DIVA,

Research director: David Sherris R&D expertise: R&D and manufacture of drug products designed to enhance the clinical efficacy of chemicals and radiation cancer treatment. R&D collaboration: Boston University; University of Texas, M.D. Anderson; Arizona State University; University of Lund, Sweden; University of Kentucky; Georgetown University; University of Florida; Baylor University; and the Gray Laboratory. Key license and trade contracts: Arizona State University and Boston University — Oxigene is licensee under both agreements. Technological expertise: D-D, AF, SMC, SY Main products/instrumentation under R&D: Diagnostics; Declopramide to treat, advanced cancer, Phase II/III; Combretastatin A4 Prodrug to treat advanced cancer, Phase II/III, Cordycepin, to treat ALL (Acute Lymphocytic Leukemia), Phase I/II; combretastatin (CA4P), angiogenesis inhibitor, for treatment of advanced cancer, solid tumors, Phase III, 2008;

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nicotinamides to treat inflammatory diseases. Zybrestat (fosbretabulin), a vascular disrupting agent, for the treatment of polypoidal choroidal vasculopathy (PCV), Phase II, 2009. Sealed and granted patents: Tumor or cancer cell killing therapy and agents; methods of administering and pharmaceutical formulations containing N-substituted benzamides and/or acid addition salts; methods of administering phenothiazines and/or addition salts; use of aryl N-substituted carboxamides directly and as radio- and chemosensitizers for killing tumor and cancer cells and novd compounds for such use; test to determine predisposition or susceptibility to DNA associated diseases; method of testing immune competency; carotenoid-nicotinamide-zinc composition and methods of treatment using same; glutathioneS-transferase-mu as a measure of drug resistance; useful formulations of acid addition salt drugs; compositions and use of benzamides and nicotinamides as anti-inflammatory drugs; other patents pending.

2130

OXYRASE, INC.

2131

663

OYSTER BAY PUMP WORKS, INC.

Add: 78 Midland Avenue, P.O. Box 725 Hicksville, NY 11802-0725 Tel: (516) 933-4500 Fax: (516) 933-4501 E-mail: [email protected] Web site: www.obpw.com President: Patrick Gaillard R&D expertise: Design, development/manufacture of automated liquid dispensing systems and automated manufacturing systems. Technological expertise: CH/S, HTDS, PMC, R Principal products/instrumentation: Microplate Coating Systems, Test Tube Coating Systems, High Throughput Drug Screening Systems, Liquid Dispensing Systems, Custom Automation. Main products/instrumentation under R&D: Automated liquid dispensing systems.

2132

OZYME SARL

Add: P.O. Box 1345 Mansfield, Ohio 44901

Add: 10 Av. Ampere, BP 268 St. Quentin/ Yvevines 78053 Cedex France

Tel: (419) 589-8800

Tel: (33) 1-3085-9292

Fax: (419) 589-9919

Fax: (33) 1-3460-9212

E-mail: [email protected]

E-mail: [email protected]

Web site: www.oxyrase.com

President: Martin Lauriot-Prevost

President: Dr. James Copeland

R&D expertise: R&D/manufacture of reagents and laboratory equipment (molecular biology, cell biology, immunology research).

Technological expertise: E, ET R&D expertise: Design, development and manufacture of oxyrase and other biotechnology medicines. Principal products/instrumentation: Oxyrase for Broth, Oxyrase for Agar Oxyplates, and Oxydishes. Main products/instrumentation under R&D: Novel biotechnology medicines.

Technological expertise: BME, C/TC Principal products/instrumentation: Biologicals, human genome project, instrumentation, reagents Main products/instrumentation under R&D: Reagents and laboratory equipment for molecular biology/cell biology/immunology research.

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PAA LABORATORIES

Web site: www.pacbio.com President/CEO: Paul Kanan

Add: Wiener Strasse 131 A-4020 Linz Austria Tel: (43) 732-330-890 Fax: (43) 732-330-894 E-mail: [email protected] Web site: www.paa.com President: Rainer C. Burian Research director: Ulrich Delvos, Ph.D. R&D expertise: Manufacturing and marketing of sera, media, supplements and reagents for cell culture; supply to cell culture, academic and biopharmaceutical industry. R&D collaboration: University of Vienna; University of Prague; National Institute of Animal Disease, Vienna. Key sales market contracts: University of Graz, Austria; New York Blood Center, U.S.A.; Mediatech, U.S.A.

R&D expertise: R&D/manufacture of noninvasive medical diagnostics for detection and management of chronic disease. Technological expertise: PA, P/S, BI, PIS Principal products/instrumentation: Osteopatch™ for the diagnosis and management of osteoporosis; contract research/clinical trial products. Main products/instrumentation under R&D: Non-invasive glucose diagnostics for management of diabetes, non-invasive medical diagnostics for detection and managements of chronic diseases. Subsidiary bodies: Clinical trial support reference lab in Seattle, WA.

2135

PACIFIC LATEX PRODUCTS

Technological expertise: C/TC Principal products/instrumentation: Animal sera, fetal bovine serum, media and serum free media; VIRALEX™ Virus Inactivated Foetal Bovine Serum, CYTOFERR™ Protein Free Medium for CHO cells and hybridoma, specialty chemicals. Main products/instrumentation under R&D: Virus Inactivated reagents; IgG Free Animal Sera; serum free media, reagents for cell culture. Subsidiary bodies: PAA Laboratories, Ltd., U.K.; PAA Laboratories, Germany; PAA Laboratories, Inc., U.S.A.; PAA Laboratories, Japan.

2134

PACIFIC BIOMETRICS, INC.

Add: 220 West Harrison Street Seattle, WA 98119 Tel: (206) 298-0068 Fax: (206) 298-9838 E-mail: [email protected]

Add: 2 Clarence Place #12 San Francisco, CA 94107 Tel: (415) 827-8595 Fax: (415) 979-9019 E-mail: [email protected] Web site: www.gloves.com President/CEO: Michael L. Gamble Research director: T. Gamble Subsidiary of Malgam Enterprises. R&D expertise: Import/export of biomedical equipment/instrumentation. Key sales market contracts: Own private label on various products. Technological expertise: CH/S, BME. Principal products/instrumentation: HandCare® brand exam and industrial grade nitrile (powder-free textured) gloves; Hand-Care® brand disposable single-use safety lancets; Hypoallergenic powdered exam gloves; vinyl exam gloves; General purpose lancets; universal

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self-retracting lancing device; High-risk gloves, toxic waste processing, biologicals.

Technological expertise: HTDS, G, BME, FL, AU, AMS, R, CH/S, CB, C/TC

Subsidiary bodies: Warehouses: Houston, TX; Newark, NJ.

Principal products/instrumentation: BioSignal™ products and services mark, BRET2™ assay reagent, COBRA Quantum® gamma counting system, COBRA® gamma counting system, ContractScreen™ drug screening service, CulturPlate™ microplate, Cyclone™ storage phosphor system, CytoLite™ bioluminescent reagent, CytoTools™ reagents, DeepBlueC™ modified coelanterazine reagent, Discovery™ Microplate Analyzer, FilterMate™ harvester, FlashPlate® microplate, FlashScreen™ assay, Fluoro-Count® fluorescence microplate reader, AlphaQuest™ microplate analyzer, AlphaScreen™ assay technology, ATPLite™ bioluminescent cell viability assay, AutoGamma® scientific electronic apparatus and instruments, A*L*P*H*A™, BioChip Arrayer™ non-contact microdispensing system, BioChip Imager™ microarray imaging device, BioSignal™ products and services mark, BRET2™ assay reagent, COBRA™ Quantum® gamma counting system, COBRA™ gamma counting system, Contract-Screen™ drug screening service, CulturPlate™ microplate, Cyclone™ storage phosphor system, Cyto-Lite™ bioluminescent reagent, CytoTools™ reagent, DeepBlueC™ modified coelanterazine reagent, Discovery™ Microplate Analyzer, FilterMate™ harvester, FlashPlate ® microplate, FlashScreen™ assay, Fiuoro-Count™ fluorescence microplate reader, HydroGel™ 3D substrate, HydroGel™ chip, a 3D substrate for microarrays, InstantImager® electronic autoradiography system, LucLite® and LucLite® Plus bioluminescent reagent, LumaPlate™ microplate, LumiCount® luminescence microplate reader, Matrix™ microplate gas flow proportional reader, Minaxi™ gamma counter, MiniTrak™ automated microplate processing system, MultiPROBE® II robotic liquid handling system, Packard® products and services mark, PiezoTip™ dispenser, PiezoTipnology™ technology, PlateStak™ automated plate

2136

PACIFIC SCIENTIFIC INSTRUMENTS

Add: 481 California Ave. Grants Pass, OR 97526 Tel: (541) 479-1248 Fax: (541) 479-3057 President: Dan Pryor Research director: Dr. DeFreez Subsidiary of Hach Lange. R&D expertise: Development, manufacture and marketing of particle counting instruments. Technological expertise: P/S, PMC Principal products/instrumentation: Portable™ Air Particle Counter, ROYCO™ Air Particle Counter, Microair™ Particle Counter, HIAC Liquid Counters. Main products/instrumentation under R&D: Particle counting instruments.

2137

PACKARD BIOSCIENCE CO.

Add: 800 Research Parkway Meriden, CT 06450 Tel: (203) 639-2598 Fax: (203) 639-2172 President: Frank Witney Research director: Staf Van Cauter R&D expertise: R&D, manufacture and marketing of liquid scintillation counters, gamma scintillation counters, robotic liquid handlers, digital imaging systems and molecular biology systems and instrumentation use in pharmaceutical/genomics industry.

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handling system, PlateTrak™ automated microplate processing system, PlateWash™ microplate washer, ProxiPlate™ microplate, QuantArray® microarray analysis software, QuantaSrnart™ Tri-Carb® LSC software, Radiomatic™ flow scintillation analyzer, RiaStar™ manual gamma counter, ScanArray® microarray analysis photometric microplate Reader, TopCount® microplate scintillation luminescence counter, TopCount® NXT™ microplate scintillation luminescence counter, TR-LSC™ technology, Tri-Carb® time-resolved liquid scintillation analyzer, VersaTip® pipetting tips, ViewPlate® microplate, WinPREP® software. Main products/instrumentation under R&D: Liquid scintillation counters, gamma scintillation counters, robotic liquid handlers, digital imaging systems, molecular biology systems, instruments for pharmaceutical/genomics research. Subsidiary bodies: The following companies are subsidiaries of Packard BioScience Company: Packard Instrument Company, Inc., BioSignal Packard, Inc., CCS Packard, Inc., Packard BioChip Technologies, LLC, Packard BioScience B.V.; Contact: Tricia Caldwell Corporate Communications, Tel: (203) 6392439, Fax: (203) 235-1347, E-mail: [email protected]. Sealed and granted patents: Strong Microdispending Technology Patent Portfolio: October 13, 2000 — awarded U.S. Patent 6,112,605, entitled “Method for Dispensing and Determining a Microvolume of Sample Liquid”. The 31 claims of this patent cover methods and devices to enable low-cost, industrial-scale manufacturing of protein and DNA microarrays by using robot-controlled, inkjetstyle printing technology. August 8, 2000 — awarded U.S. Patent number 6,094,966, entitled, “Method for Verifying Proper Operation of a Liquid Sample Dispenser”. The patent covers methods for using Packard’s pioneering-piezo-electric dispensing technology with its computer-controlled robotic liquid handling

systems to deliver minute droplets which enable the production of inexpensive, high-quality biochips and microarrays. July 11, 2000 — awarded U.S. Patents 6,079,283 and 6,083,762 which together include 44 claims providing broad and fundamental coverage encompassing biochip production by transfer of liquids through non-contact dispensing. These patents cover methods and devices for aspirating liquids and dispensing nanovolume droplets containing biomolecules such as DNA, proteins and cells. This non-contact droplet dispensing technology, also known as “dropon-demand” dispensing, is analogous to inkjetting technology and enables the inexpensive production of high-quality gene chips and protein chips. July 1999 — awarded U.S. patent 5,927,547, entitled “System for Dispensing Microvolume Quantities of Liquids”. This patent includes 14 claims, providing a broad coverage of very small volume liquid dispensing; other patents pending.

2138

PALL CORPORATION

Add: 25 Harbor Park Drive Port Washington, NY 11050 Tel: (516) 484-5400 Fax: (516) 484-5228 E-mail: [email protected] Web site: www.pall.com President: Jeremy Hayward-Surry Research director: John Miller R&D expertise: R&D, manufacture and marketing of separations and analysis products for drug discovery and bioprocessing. Technological expertise: P/S, BA, COC Principal products/instrumentation: Biologicals, biomaterials, biosensors, chemicals, cosmetics, diagnostics, pharmaceuticals, process validation, contract R&D products, vaccines

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Main products/instrumentation under R&D: Separation technologies and analysis instruments for drug discovery and bioprocessing.

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Tel: (734) 665-0651 E-mail: [email protected] Web site: www.pall.com/gelman. CEO: Eric Krasnoff

2139

PALL FILTRON CORP.

Research director: Eric Sklar Subsidiary of Pall Corporation.

Add: 50 Bearfoot Rd. Northborough, MA 01532 Tel: (508) 393-1800 Fax: (508) 393-1874 E-mail: [email protected] Web site: www.pall.com. President: Charles Robrecht Research director: Attila Herczeg Subsidiary of Pall Corp. R&D expertise: Bioprocess engineering research; manufacture UF/MF membrane products for laboratory, pilot and process-scale applications. Key sales market contracts: Asahi Chemical Co., Tokyo.

R&D expertise: R&D, manufacture and marketing of filtration and separations in the laboratory. Technological expertise: P/S, C/TC, COC, HTDS Principal products/instrumentation: ACRODISC™ syringe filters-sterile, NANOSEP™ centrifugal filtration devices, SPIRALCAP™, filter capsule, BIODYNF™ transfer membrane. Main products/instrumentation under R&D: Filtration and separation devices for laboratory use. Sealed and granted patents: SPIRALCAP, SUPOR MEMBRANE, BIODYNE TRANSFER MEMBRANE.

Technological expertise: E, F, BA, LP, P/S Principal products/instrumentation: Centrasette™, Minisette™, Maxisette™, 10ml stirred cell, 150ml stirred cell, Ultrasette™, MiniUltrasette™, Microsep™, Nova™ series membranes, Omega™ series membranes, Alpha™ series membranes, Sigma™ series membranes, Macrosep™, Maximate™, Maximate-Ext™, Maxisette™-AT, NANOSEP™, CENTRAMATE™, CENTRASETTE™-AT 5 and 10, ULTRAFUGE IT™, Jumbosep, Nanosep MF, MINIM™; MAXIM™; ADAM™; REGEN series membranes; MICROZA Hollow fiber membranes; PALLSEP membrane systems. Main products/instrumentation under R&D: Bioprocess engineering technologies, UF/MF membranes for Lab/pilot/process-scale use.

2141

Add: Max-volmer-Strasse 4 Hilden, Germany 40724 Tel: (49) 210-3291-2400 Fax: (49) 210-3292-2000 Web site: www.qiagen.com/palliance/index.htm. Subsidiary of DNA Service offered by Qiagen. R&D expertise: Contract R&D/manufacturing of plasmid DNA and vaccines. Technological expertise: F, P/S, GT Principal products/instrumentation: Contract manufacturing products, plasmid DNA, vaccines.

2142 2140

PALLIANCE

PALL ULTRAFINE FILTRATION CO.

PALL GELMAN LABORATORY

Add: 600 S. Wagner Road Ann Arbor, MI 48103

Add: 25 Harbor Park Dr. Port Washington, NY 11050

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Tel: (516) 484-5400 Fax: (516) 801-9754 E-mail: [email protected]

Main products/instrumentation under R&D: Anti-infectives, anti-cancer, immune stimulation and CNS drugs, pharmaceutical-based on natural product discoveries.

Web site: www.pall.com President: Peter Cope Research director: Thomas Gsell, Ph.D.

2144

PANBIO PTY, LTD.

Subsidiary of Pall Corp. R&D expertise: Bioprocess engineering research, design/manufacture/marketing of filtration products for the production of contamination-free pharmaceuticals and biologicals. Technological expertise: F, E, C/TC, BA, LP, P/S Principal products/instrumentation: Ultipor® N~66 filters, N-66 Posidyne® filters, Fluorodyne® II-P filters, Profile II® filters, Profile II Plus® filters, Bio-Inert filters, Emflon® II filters, Ultipor GF™ filters, Ultipor GF Plus® filters, Pall filter housings, KLEENPAK Filter Assemblies, DMF™ dynamic membrane filters, Microza™ ultrafiltration modules, MiniDMF™ dynamic membrane, UltiPur® VF™ virus filters. Main products/instrumentation under R&D: Filtration products for contamination-free drugs manufacture.

2143

PANAX PHARMACEUTICALS CO., LTD.

Add: 532 Seventeen Mile Rocks Rd Sinnamon Park Queensland 4073 Australia Tel: (61) 7-3363-7100 Fax: (61) 7-3363-7199 E-mail: [email protected] Web site: www.panbio.com.au Research director: Dr. Peter Devine R&D expertise: Development, design and manufacture of clinical and agricultural diagnostic test kit. R&D collaboration: QIMR, QUT, University of Queensland, CSIRQ, Macquarie University. Key sales market contracts: Biotrin, INDX, MRL, Endosafe, Trinity, Biostar. Key license and trade contracts: Binax. Technological expertise: C/TC, P/S Principal products/instrumentation: Biologicals, diagnostics, reagents, infectious disease tests, rapid tests, agricultural diagnostics. Main products/instrumentation under R&D: Clinical and agricultural test kits.

Add: 425 Park Avenue 27th Floor New York 10022 Tel: (212) 319-8300 Fax: (212) 751-4131 President/CEO: Dr. Taffy J. Williams, Ph.D. Research director: Dr. Robert Kiele, Ph.D. R&D expertise: Development and manufacture of pharmaceuticals-based on natural product discoveries. Technological expertise: AF, COC, D-D, HTDS, P/S, SMC, SY

2145

PANIGEN, INC.

Add: W8959 Hwy. 39 Blanchardville, WI 53516-9633 Tel: (608) 523-1903 Fax: (608) 523-1909 E-mail: [email protected] Web site: www.panigen.com President: Jacqui Leighton

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Research director: Jacqui Leighton R&D expertise: Custom development and manufacture of antisera. Technological expertise: PA, P/S, C/TC, H/CF

2147

PANORAMA RESEARCH, INC.

Add: 2462 Wyandotte St. Mountain View, CA 94043

Principal products/instrumentation: Agriculture, biologicals, biosensors, contract manufacturing products, contract research/clinical trial products, goat anti-chicken polyclonal AB, goat anti-peanut allergan AB.

Tel: (650) 694-4996

Main products/instrumentation under R&D: Antisera and their related products.

President/CEO: James Larrick

2146

PANLABS, INC.

Add: C/Energia, 112 08940 Cornellà (Barcelona) Spain Tel: (34) 934-750-697 Fax: (34) 934-190-709 E-mail: [email protected]

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Fax: (650) 694-7717 E-mail: [email protected] Web site: www. pano.com Research director: James Larrick R&D expertise: R&D and manufacture of novel products for drug discovery. Technological expertise: DD, D-D, DDI, C/TC, BI, BTS, CH/S, COC, HTDS, SSMSA Main products/instrumentation under R&D: Memantine, Apoptosis reagents, novel drugs to treat cancer and autoimmunity diseases, drugresistance gene, drug prototype, drug discovery route.

Web site: www.panlabs.com President/CEO: Doug Squires, Ph.D. Subsidiary of MDS, inc. R&D expertise: Contract research, design and preclinical development for drug discovery; preclinical pharmacology process improvement; biosafety testing; related novel products manufacture. Technological expertise: E, F, Q, BA, C/TC, GA, HTDS, RD Principal products/instrumentation: Pharmaceuticals, biologicals, bioremediation, contract research/clinical trial products, in vitro toxicology testing method, process validation, pharmaScreen®, DiscoveryScreen®, Custom Screen®, ImmunoScreen®, ProfilingScreen® for pharmacological testing. Main products/instrumentation under R&D: New discovery drugs. Subsidiary bodies: Taipei, Taiwan; Geneva, Switzerland.

2148

PANOZYME BIOCHEMICALS

Add: 2462 Wyandotte St. Mountain View, CA 94043 Tel: (415) 694-4996 Fax: (415) 694-7717 Research director: Jamil Talhouk, Ph.D. Subsidiary of Panorama Research, Inc. R&D expertise: Contract R&D of biochemicals and biological drugs. Technological expertise: E, CG, COC, PIS, SMC, SY Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial product, diagnostics, reagents. Main products/instrumentation under R&D: Specialty biochemicals, novel biological drugs.

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PANTECH INSTRUMENTS

Research director: Charles A. Thomas, Jr., Ph.D.

Add: 102, Shailja Complex II, Near R.C. Patel Estate, Akota — Padra Road, Vadodara — 390020, Gujarat, India.

R&D expertise: Human diagnostics development, manufacture and marketing.

Tel: (91) 982-401-6466

Principal products/instrumentation: Human antioxidant defense system diagnostic testing products.

Fax: (91) 265-233-1380 E-mail: [email protected]; [email protected] Web site: www.pantechindia.com

Technological expertise: DK, BC

Main products/instrumentation under R&D: Antioxidant defense system diagnostic products, human diagnostic kits.

President: Angel Lo Research director: Janson Chien R&D expertise: Development and manufacture of life science products, labware, biomedical analytical instruments, semiconductor equipment and chemical research, food microbiology testing technique, etc.

2151

PANVERA CORP.

Add: 565 Science Drive, Madison, WI 53711 Tel: (608) 233-9450 Fax: (608) 233-3007

Technological expertise: BME, SI.

E-mail: [email protected]

Procipal products/instrumentation: Agriculture, biologicals, biomaterials, bioremediation, biosensors, chemicals, clinical tests, cosmetics, detergents, diagnostics, food processing, human genome project, instrumentation, in vitro toxicology testing, minerals, natural products, organ transplants/culture, pesticides, pharmaceuticals, plastics, reagents, vaccines, veterinary products, contract R&D products.

President/CEO: Ralph Kauten

Main products/instrumentation under R&D: Biomedical analytical instruments, food microbiology testing technologies, semiconductor equipments.

2150

PANTOX CORP.

Add: 4622 Santa Fe St. San Diego, CA 92109 Tel: (858) 272-3885 Fax: (858) 272-1621 Web site: www.pantox.com President/CEO: Michael J. Flood

Research director: Tom Burke, Ph.D. R&D expertise: Research, development and production of biological reagents under GMP guidelines for clinical diagnostic and scientific research applications. Joint ventures: Mirus Corporation. Key sales market contracts: TaKaRa Shuzo; Medical and Biological Laboratories; Minis Corp., Fisher Scientific. Technological expertise: F, E, PA, P/S, RD, GA, C/TC, HTDS, PG, BME, FL Principal products/instrumentation: Fluorescence Products and Fluorescence Polarization Instruments, Human Proteins, Biological Assay Kits, PCR Products, reagents, human genome project, diagnostics, contract manufacturing products. Main products/instrumentation under R&D: Biological reagents for clinical diagnosis and research. Sealed and granted patents: In Fluorescence Polarization; other patents pending.

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2152

PARACEL, INC.

671

President/CEO: Bernard M. Landes Research director: Bernard M. Landes

Add: 80 S. Lake Ave., Ste. 650 Pasadena, CA 91101-2616 Tel: (626) 744-2000 Fax: (626) 744-2001 E-mail: [email protected] Web site: www.paracel.com President/CEO: Kwang-I Yu, Ph.D. R&D expertise: R&D, manufacture and marketing of high-performance genetic data and text analysis systems for the pharmaceutical, biotechnology, commercial and government department. Technological expertise: BI, CN/S, G Principal products/instrumentation: Gene Matcher™, Bio View Toolkit™, BioView Workbench™. Main products/instrumentation under R&D: High-performance genetic data and text analysis systems for drug/biotech research. Subsidiary bodies: Support Office: Hiroshi Shishido, VP Business Development, 3833 N. First St., San Jose, CA 95134, Tel: (408) 2320700; Tom Brady, Dir. Of East Coast Oper, 10420 Little Patuxent Pkwy, Ste. 495, Columbia, MD, 21044, Tel: (410) 715-5530. Sealed and granted patents: System and method for improving the accuracy of DNA sequencing and error probability estimation through application of a mathematical model to the analysis of electropherograms. 6,681,186 U.S.

R&D expertise: Development, manufacture and application of functional bioassays used for quality assurance of herbs, botanicals, and other dietary supplements, in the development of dietary supplement, OTC and pharmaceutical products, and in monitoring environmental toxins and identifying carcinogens. R&D collaboration: Paracelsian and the Southern Research Institute, working collaboratively to research and develop/manufacture new anti-cancer drugs. Technological expertise: D-D, DD, HTDS Principal products/instrumentation: In vitro toxicology testing method, new anti-cancer drug, natural products, natraceuticals, diagnostics. Main products/instrumentation under R&D: Functional bioassays for quality assurance of herbs, botanicals, etc. Sealed and granted patents: Ah-Immunoassay technology, In-vivo-CDK and In vitro CDK assays.

2154

PARADIGM GENETICS, INC./ICORIA, INC

Add: 108 Alexander Drive, RTP, North Carolina 27709-4528, U.S.A. Tel: (919) 425-3000 Fax: (919) 544-8094 Web site: www.paragen.com President/CEO: John A. Ryals, Ph.D.

2153

PARACELSIAN, INC.

Add: 95 Brown Rd, #1005 Ithaca, NY 14850 Tel: (607) 257-4224 Fax: (607) 257-2734 E-mail: [email protected]

Research director: John Harner, Ph.D. R&D expertise: R&D of industrializing gene function discovery, related novel products development. Joint ventures: PE Biosystems — develop bioinformatics software for functional genomics.

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R&D collaboration: Paracel, Inc. — GeneMatcher™ for high throughput data analysis; Prionics AG — innovative diagnostics for the rapid detection of Bovine Spangiform Encephalopathy; Bayer AG — herbicide discovery. Monsanto/Pharmacia — product discovery platform research.

2156

PARALLEL BIOTECHNOLOGIES, LTD.

Add: 4 Ravenhill Rd. Turramurra, NSW 2074 Australia Tel: (61) 4-1746-6106

Technological expertise: R, Q, T, BI, G, RD

E-mail: [email protected]

Principal products/instrumentation: Agriculture, nutraceuticals, food industrial products, biopharmaceuticals

Web site: www.parallelbiotech.com

Main products/instrumentation under R&D: Industrializing gene function discovery technology, modified minimal promoters. Sealed and granted patents: Modified nucleotide sequence encoding a LesA DNA binding domain optimized for arabidopsis species. 6,399,857, U.S.; Modified minimal promoters.6,376,746, U.S. 2155

PARAGON BIOSERVICES, INC.

Add: UMB BioPark 801 West Baltimore Street. Suite 401 Baltimore, MD 21201

President: David Mitchel, Ph.D. R&D expertise: Development of genomics of biodiversity, related novel products manufacture. Technological expertise: E, AF, COC, RD, R Principal products/instrumentation: Agriculture, bioremediation, natural products, biopharmaceuticals, contract R&D products. Main products/instrumentation under R&D: Genomic imprinting, genosome of biodiversity.

2157

PAREXEL INTERNATIONAL CORP.

Tel: (410) 975-4050

Add: 200 West Street, Waltham, MA 024511163

Fax: (410) 605-2028

Tel: (781) 487-9900

E-mail: [email protected]

Fax: (781) 487-0525

Web site: www.paragonbioservices.com

E-mail: [email protected]

President/CEO: Marco A. Chacon, Ph.D.

Web site: www.parexel.com

Research director: Erich Blatter, Ph.D.

CEO: Josef von Rickenbach

R&D expertise: Biomedical drugs research; contract research organization: angiogenesis, cancer, infectious diseases research, etc.

Research director: Jonathan Fishbien, M.D.

Technological expertise: F, PA, BA, C/TC, GA, H/CF, P/S, PIS Principal products/instrumentation: Contract manufacturing products, human genome project, biopharmaceuticals, reagents, contract R&D products. Main products/instrumentation under R&D: Biomedical drugs to treat cancer, angiogenesis, etc.

R&D expertise: Research of product development strategies; clinical trial management Phase I–IV. Technological expertise: D-D, G Principal products/instrumentation: Literature — Biologics Development: A Regulatory Overview; New Drug Development: A Regulatory Overview; Pharmaceutical R&D Statistical Sourcebook; An International Regulatory and Strategy Report; U.S. Regulatory Reporter; Medical Devices Obtaining FDA

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Market Clearance; Worldwide Pharmaceutical Regulation Series; Drug Formularies and the Pharmaceutical Industry. Subsidiary bodies: AFB — Parexel GmbH, Universitatsklinikum Rudolf Virchow Standort Charlottenburg, Haus l8, Spandauer Damm 130, D-14050 Berlin; Parexel International Ltd., Craven House, 40 Uxbridge Rd., Ealing W5 2BS, U.K.; Barnett international, 500 West Dutton’s Mill Rd., Aston, PA, 19014.

2158

PARTEC, LTD.

Add: 216 Jaffa Rd. Jerusalem 94583 Israel Tel: (972)-2-537-4997 Fax: (972)-2-537-5098 E-mail: [email protected] Web site: www.partec-ltd.com

673

Fax: (570) 839-0955 President/CEO: J.J. Bertrand Research director: A. Lindberg Subsidiary of Rhone-Poulenc SA. R&D expertise: R&D/manufacture of immunological products and preventive medicine. Joint ventures: PM-MSD, a joint venture with Merck, Sharp, Technological expertise: ET, E, CB, C/TC Principal products/instrumentation: Vaccines, biogicals. Main products/instrumentation under R&D: Immunological enhancement agents, immunologic adjuvant, immunomodulator, novel preventive medicines. Sealed and granted patents: Various patents pending, preclinical.

CEO: Morris Lautes, M.D. Key license and trade contracts: Alfa Wasserman, Children’s Hospital of Boston, Hebrew University, Hadassah University Hospital. R&D expertise: Development, manufacture and marketing of diabetic therapeutic drug, cancer gene therapy. Technological expertise: RD, BI, CB, C/TC, DD, GT, PIS, PG Main products/instrumentation under R&D: Sulodexide-GR for Diabetic Nephropathy, Phase II/III; SRC Inhibitor for Prostate CA, preclinical; Inhibitor for chemotherapy induced alopecia, preclinical; H19 cancer gene therapy, preclinical.

2159

PASTEUR MERIEUX CONNAUGH

Add: P.O. Box 187, Swiftwater, PA 183700187 Tel: (570) 839-7187

2160

PATHEON INC.

Add: P.O. Box 110145 Research Triangle Park, NC 27709-5145 Tel: (905) 821-4001 Fax: (905) 812-6791 E-mail: [email protected] Web site: www.patheon.com President: Nick DiPietro R&D expertise: Research of biotechnology medicines, related novel product development and manufacturing. Technological expertise: AB, AF, SMC, DD Principal products/instrumentation: Contract manufacturing products, biologicals, contract research/clinical trial products. Main products/instrumentation under R&D: Biochips, biochemical reagents, biotechnology medicines for immune enhancement. Subsidiary bodies: Five facilities in North America, three in Europe.

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PATHOGENESIS CORP.

Add: 201 Elliott Ave., West Seattle, WA 98119 Tel: (206) 467-8100

Technological expertise: C/TC Principal products/instrumentation: Human tissue and organs for research, development and education purpose.

Fax: (206) 270-3313 Web site: www.pathogenesis.com

2163

PAVLOS ARNAOUTIS, SA.

President/CEO: Wilbur H. Gantz Research director: A. Bruce Montgomery, M.D. R&D expertise: Research, development and manufacture of drugs to treat serious, chronic human infectious diseases. Key license and trade contracts: Cystic Fibrosis Foundation and Children’s Hospital and Medical Center, Seattle, for aerosolized tobramycin/aminoglycosides for broncho pulmonary infections; Kaneka Corp. for PA-1648 for tuberculosis and other infections. Technological expertise: BI, C/TC, COC, CH/S, DD, D-D, GA, HTDS, R, Q, SMC Main products/instrumentation under R&D: TOBI for chronic pseudomonal using infections in cystic fibrosis- NDA filed 2Q; TOBI for bronchiectasis; TOBI for tuberculosis; PA1648 for tuberculosis, Phase III trials (3 total).

Add: 4 Thermopilon St Halandri Athens 15233 Greece Tel: (30) 1-685-4400 Fax: (30) 1-685-8303 E-mail: [email protected] Web site: www.arnaoutis.gr President: Paul A.B. Arnaoutis R&D expertise: R&D, manufacture and marketing of diagnostic/research instrument and reagents. Technological expertise: C/TC, COC Principal products/instrumentation: Clinical tests, diagnostics, organ transplants/culture products, pharmaceuticals, regents. Main products/instrumentation under R&D: Novel diagnostic/research instrument, reagents.

2164 2162

PATHSERVE AUTOPSY & TISSUE BANK

PBL INTERFERON SOURCE

Add: 131 Ethel Road West, Suite 6 Piscataway, NJ 08854-5900

Add: P.O. Box 22023 San Francisco, CA 94122

Tel: (877) 725-8881

Tel: (415) 664-9686

Fax: (732) 777-9123

Fax: (415) 664-5861

E-mail: [email protected]

E-mail: [email protected]

Web site: www.interferonsource.com

Web site: www.tissuebank.com

President: Sidney Pestka, M.D.

President: Tony Schnider

Research director: Sidney Pestka

Research director: Roman Karp

R&D expertise: Research, development and manufacturing of antibodies, kits and advanced interferons.

R&D expertise: Research and manufacture of cell and tissue culture, human tissues and organs products for research and development of novel drugs.

Technological expertise: F, PA, Q, P/S, SY, PIS, AB, BA, C/TC, D-D, GA, GT, H/CF, RD

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Principal products/instrumentation: Contract research/clinical trial products, research reagents including interferons and cytokines, antibodies and ELBA kits; patented Super Protein Technology (SPT); patented Tumor Target Technology (TTT).

Tel: (44) 1792-310-454

Main products/instrumentation under R&D: Advanced interferons and cytokines for the treatment of cancer and other diseases; proprietary Tumor Target Technology for radiolabeling of monoclonal antibodies, diagnostic assay technology.

R&D expertise: R&D of biotechnology products.

Sealed and granted patents: Advanced interferons and other “Super Proteins”; phosphorylation technology; diagnostic assay technology.

2165

PBR LABORATORIES, INC.

Fax: (44) 1792-310-331 Web site: www.pci-memtech.com Research director: Benoit Fradin Subsidiary of Thames Water Products.

Technological expertise: P/S Principal products/instrumentation: Nutraceuticals, specialty chemicals, pharmaceuticals, cosmetics, vaccines, peptide, biologicals, contract R&D products. Main products/instrumentation under R&D: Biotech drugs, biotechware.

2167

PCP, INC.

Add: 9960-67 Avenue NW, Edmonton, Alberta, T6E 0P5 Canada

Add: 2155 Indian Rd. West Palm Beach, FL 33409-3287

Tel: (780) 450-3957

Tel: (561) 683-0507

Fax: (780) 450-3960

Fax: (561) 683-0507.

E-mail: [email protected]

President/CEO: Martin J. Cohen

Web site: www.pbr.ca President: Dr. Ram D. Mehta Research director: Dr. Ram D. Mehta R&D expertise: Research of in vitro toxicology and environmental monitoring methods, related novel products development and manufacture. Technological expertise: C/TC Main products/instrumentation under R&D: Environmental monitoring control, in vitro toxicology testing method, immuno assay kit for microcystins.

2166

PCI — MEMTECH

Add: Lion Way Swansea Enterprise Park Swansea SA7 9FB U.K.

Research director: Robert M. Stimac R&D expertise: Development, manufacture and marketing of ion mobility spectrometers for the detection of trace chemicals. Technological expertise: CS, BME, AMS Principal products/instrumentation: Ion Mobility Spectrometers (IMS) for detection of trace chemicals, Combination IMS Mass Spectrometers (IMS/MS).

2168

PDR-CHIRAL, INC.

Add: 1331A South Killian Drive Lake Park, FL 33403 Tel: (561) 841-4195 Fax: (561) 841-4196

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E-mail: [email protected]

2170

Web site: www.pdr-chiral.com. President/CEO: Gary W. Yanik Research director: Gary W. Yanik R&D expertise: R&D of chiral chemistry, related novel products manufacture. R&D collaboration: University of Arkansas, University of Missouri @ Rolla, and University of Southern California.

PEGASUS BIOTECHNOLOGY, INC.

Add: 530 Massey Rd. Guelph, Ont. NIK 1B4 Canada Tel: (519) 766-1491 Fax: (519) 766-1492. President/CEO: Neal Trent

Key sales market contracts: Hewlett-Packard, Chiral Technologies, and ASTEC.

R&D expertise: R&D of fermentation (animal cell bioreactor), biosensors, related novel products manufacture.

Technological expertise: CC, E, F, BA, CB, COC, D-D, HTDS.PIS, PMC, SMC, SY

R&D collaboration: National Research Council of Canada

Principal products/instrumentation: PDRChiral Advanced Laser Polarimeter with interchangeable flow cells for HPLC, preparative, SFC, and process.

Technological expertise: F, PMC, BME, SI

Main products/instrumentation under R&D: CE Flow Cell, laser polarimetry. Sealed and granted patents: U.S. PatentLaser Polarimetry; International patents on above filed and pending.

Principal products/instrumentation: Microfresh™ analyzer. Main products/instrumentation under R&D: Cellstream™ bioreactor, Salmonella sensor, lactate, glutamate/glutamine sensor, biosensors.

2171

PEGASUS SCIENTIFIC, INC.

Add: 15779 Columbia Pike #760 Burtonsville, MD 20866 2169

PE AGGEN, INC.

Add: 2411 S. 1070 W. Salt Lake City, UT 84119 Tel: (801) 975-1188 Fax: (801) 975-1244 E-mail: [email protected] President/CEO: Stephen Bates Research director: Dr. Marc Malandro Subsidiary of PC Applied BioSystem. R&D expertise: R&D of applied biomedical system, related novel products manufacture. Technological expertise: BME Main products/instrumentation under R&D: Contract R&D products, applied biomedical system, biomedical associated materials.

Tel: (301) 668-9464 Fax: (301) 668-7604 E-mail: [email protected] Web site: www.pegasusscientific.com President: Scott Behrman R&D expertise: R&D of biomedical equipment, related products manufacture. Technological expertise: BME Principal products/instrumentation: Remanufacture autoclaves, centrifuges, and most biomedical equipment for the research laboratory.

2172

PEL-FREEZ BIOLOGICALS

Add: 219 N. Arkansas Street Rogers, AR 72756

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Tel: (479) 636-4361 Fax: (479) 636-3562 E-mail: [email protected] Web site: www.pelfreez-bio.com President: David Dubbell Research director: Gary Milburn R&D expertise: Bioprocess engineering research, manufacture of biological and biotechnology-derived intermediates used in medical diagnostics manufacturing. Technological expertise: F, PA, C/TC, RD, P/S, BA, H/CF Principal products/instrumentation: Rabbit brain acetone powder for coagulation diagnostics, normal sera, monoclonal and polyclonal antibodies, purified serum proteins, tissues, tissue extracts, recombinant proteins, nucleic acids and integrated protein expression systems. Main products/instrumentation under R&D: Bioprocess engineering technologies, biotechnology-derived intermediates for diagnostics. Subsidiary bodies: Pei-Freez Clinical Systems, 9099 N. Deerbrook Trail, Brown Deer, WI 53223; Novagen, 597 Science Dr., Madison, WI 53711.

2173

PENCE, INC.

Add: 8308-114th St. Research Transition Facility Edmonton, AB T6G 2V2, Canada Tel: (780) 492-8851 Fax: (780) 492-6995 CEO: Dr. Robert Hodges R&D expertise: Drug discovery, design and applied research in protein engineering, leading to commercialization and new company creation. R&D collaboration: PENCE agreements with major pharmaceutical companies and biotechnology companies.

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Key sales market contracts: PENCE agreements with major pharmaceutical companies and biotechnology companies. Key license and trade contracts: PENCE agreements with major pharmaceutical companies and biotechnology companies. Technological expertise: CC, E, F, PA, Q, TE, T, AF, AB, BI, BA, BS, CB, C/TC, COC, CH/S, PIS, H/CF, R, SMC, SY, P/S, RD Principal products/instrumentation: Biologicals, contract manufacturing products, contract research/clinical trial products, instrumentation, natural products, pharmaceuticals, reagents, vaccines.

2174

PENINSULA LABORATORIES, INC.

Add: 305 Old County Road, San Carlos, CA 94070 Tel: (650) 592-5392 Fax: (650) 595-4071 Web site: www.bachem.com President: Bosco Pong R&D expertise: Bioprocess engineering, cell and tissue culture research. Novel products development and manufacture. Technological expertise: SY, PIS, PA, peptide synthesis Principal products/instrumentation: Pharmaceuticals, peptide, chemicals, reagents, cell and tissue culture. Main products/instrumentation under R&D: Bioprocess engineering technologies.

2175

PENTA MANUFACTURING CO., INC. (A DIV. OF PENTA INTERNATIONAL CORP.)

Add: 50 Okner Pkwy, Livingston, NJ 070391604

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Tel: (973) 740-2300

Tel: (44) 20-7610-3055

Fax: (973) 740-1839

Fax: (44) 20-7610-3430

E-mail: [email protected]

E-mail: [email protected]

Web site: www.pentamfg.com

Web site: www.peprotechec.com

President: G. M. Volpe

President/CEO: Anna Seymour

Subsidiary of Penta International Corp.

Research director: Anna Seymour

R&D expertise: R&D/manufacture of pharmaceutical intermediates.

R&D expertise: R&D, manufacture and marketing of recombinant growth factors, cytokines and antibodies, etc.

Technological expertise: CC, F, P/S, SMC, SY Main products/instrumentation under R&D: Contract manufacturing products, related pharmaceutical intermediates.

2176

PENTAPHARM, LTD.

Add: Engelgasse 109 Basel 4002 Switzerland

Technological expertise: F, PA, C/TC, RD, H/CF Principal products/instrumentation: Complete range of recombinant growth factors, cytokines and neutrophic factors. Main products/instrumentation under R&D: Newest cytokines, growth factors and neutrophic factors, antibodies.

Tel: (61) 61-706-4848 Fax: (61) 61-319-9619 E-mail: [email protected] Web site: www.pentapharm.com

2178

PEPROTECH, INC.

President/CEO: Caspar Sturm

Add: Princeton Business Park, 5 Crescent Ave. P.O. Box 275 Rocky Hill, NJ 08553-0275

Research director: Prof. Jurg Meier

Tel: (609) 497-0253

R&D expertise: R&D of cosmetics, diagnostics, biochemicals, etc., related novel products manufacture.

Fax: (609) 497-0321

Technological expertise: F, E, PIS, P/S, H/CF, C/TC, SY Principal products/instrumentation: Pefachrome®, Pefabloc®, Defibrase®, Prionex®, Protac®, Glycosome®, Melawhite®, Pentavitin®, Phytaluronate®, Revitalin®, Stimu-Tex®, Stimucell®, Aprotinin, Hyaluronic Acid, Thrombin Inhibitors, Factor XIII and IX, Substrates/ Special products on request, ERYTHRULOSE, FADEOUT, DISMUTIN®-BT.

2177

PEPROTECH EC, LTD.

Add: PeproTech House 29 Margravine Road London W6 8LL U.K.

E-mail: [email protected] Web site: www.peprotech.com R&D expertise: R&D, manufacture/marketing of recombinant cytokines and growth factors. Technological expertise: PA, RD, BA, C/TC, GA Principal products/instrumentation: Recombinant human, murine and rat cytokines; growth factors, chemokines and neurotrophis factors. Polyclonal and monoclonal antibodies, recombinant proteins.

2179

PEPSCAN SYSTEMS B.V.

Add: Zuidersluisweg 2 8243 RC Lelystad The Netherlands

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Tel: (31) 320-225-300 Fax: (31) 320-225301 E-mail: [email protected]

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Antagonist G — anti-cancer peptide, PTL 78419 B — adjunct therapy in infection; veterinary: dog contraceptive peptide; peptide T for antivirus.

Web site: www.pepscan.com President: Dr. R.H. van Dam Research director: Dr. R. H. Meloen R&D expertise: Research of drug design/peptide array; related novel products manufacture. Technological expertise: PIS, COC, SY Principal products/instrumentation: Peptide arrays, peptide chips, epitope, discontinuousepitope mapping. Main products/instrumentation under R&D: Drug design through discontinuous drug design platform, peptide library.

2180

PEPTECH LIMITED

Add: Locked Bag 441 North Ryde NSW 1670 Australia Tel: (61) 2-9870-8788 Fax: (61) 2-9870-8787 E-mail: [email protected] Web site: www.peptech.com President: Dr. Michael Cohen Research director: Dr. Robert Miller R&D expertise: R&D, manufacture/marketing of peptide-based pharmaceuticals and veterinary products, pharmaceutical, etc. R&D collaboration: Imperial Cancer Research Fund, U.K.; Womans & Childrens Hospital, Adelaide, Australia; CRC Biopharmaceuticals.

2181

PEPTIDE LABORATORY

Add: 4872 East 2nd Street, Benicia, CA 94510 Tel: (707) 745-1500 Fax: (707) 746-6801 President: Robert Webber, Ph.D. Research director: Boris Pekelis, Ph.D. Subsidiary of Research & Diagnostic Antibodies R&D expertise: Custom development/synthesis of various peptides and resins for Fmoc-SPPS. Sale of stock peptides and unnatural amino acid derivatives, peptide instrumentation. Technological expertise: Q, SY, P, PS, PS/AP, P/PS, PI Principal products/instrumentation: CAT, DAS, DASRIN-3, and RAB resins for FmocSPPS. Design technique of peptide immunogens. Large scale peptide synthesis method. Hundreds of FMOC-protected unnatural amino acid derivatives available. Main products/instrumentation under R&D: Large-scale synthesis method of peptide hormones, regulators and growth factors by solid phase techniques and by segment assembly, peptide nucleic acid peptide sequencer, peptide synthesizer. Subsidiary bodies: 4175 Lakeside Dr. #140, Richmond, CA 94806.

Technological expertise: PIS, CB, DO, D-D, PPAT, PS, PI Principal products/instrumentation: Human: GMDP to treat psoriasis, infection, ophthalmology disease; Veterinary: Ovaplant (GnRH implant for fertility control). Main products/instrumentation under R&D: Human: GMDP to treat neutropenia,

2182

PEPTIDES INTERNATIONAL

Add: 11621 Electron Drive Louisville, Kentucky 40299 Tel: (502) 266-8787 Fax: (502) 267-1329

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E-mail: [email protected]

Fax: (301) 869-7308

Web site: www.pepnet.com

E-mail: [email protected]

President: Arno F. Spatola, Ph.D.

President: Martha Knight, Ph.D.

Research director: Krzysztof Darlak, Ph.D.

Research director: Martha Knight, Ph.D.

R&D expertise: Research and manufacture of specialty research chemicals and peptides. Drug discovery and development/manufacture.

R&D expertise: R&D and manufacture of peptides, peptide instrumentation, other biotechnology medicines, etc.

Key sales market contracts: Peptide Institute (Osaka, Japan)

Technological expertise: PIS, D-D, CS, CPHC, P/S, SY

R&D collaboration: Protein Research Foundation, Japan.

Principal products/instrumentation: Custom peptide synthesis; biotinylated and fluorescent peptides; conjugates and synthetic vaccines, process development techniques; Custom peptide synthesis method, analytical chemistry, preparative chromatography, biologically active peptides.

Key license and trade contracts: Research Corporation Technologies; University of Minnesota; University of Utah, Oryza. Technological expertise: PIS, CS, COC, P/S, SY, PS, D-D Principal products/instrumentation: Biologically active enzyme substrates and inhibitors; protected amino acids, antisera, peptide synthesis, resins and peptide synthesis, combinatorial chemistry and accessories; peptides, resins for peptide synthesis and combinatorial chemistry, amino acid derivatives, reagents for combinatorial chemistry and peptide synthesis. PEG Linkers: These monodisperse, discrete polyethylene glycol derivatives (dPEG™) are now available for researchers active in protein labeling and peptide design and synthesis, 2009. Main products/instrumentation under R&D: MMP Inhibitors, specialty research chemicals, combinatorial misturae of peptides, pseudopeptides and peptide mimetics, new solid phase supports. combinatorial chemistry accessories multiple and parallel synthesis apparatus.

2183

PEPTIDE TECHNOLOGIES CORP.

Add: 8401 Helgerman Ct. Gaithersburg, MD 20877 Tel: (301) 869-7306

Main products/instrumentation under R&D: Tumor necrosis factor antibodies, countercurrent chromatography of biotechnology products, Viscosin antibiotic R&D. Anti-TB and anti-cancer therapeutics. Sealed and granted patents: Viscosin mimetics, bombesin antagonists; tumor necrosis factor antibodies. 6,416,757, U.S.

2184

PEPTIDE THERAPEUTICS

Add: Peterhouse Technology Park 100 Fulbourn Rd. Cambridge CB1 9PT U.K. Tel: (44) 1223-275-300 Fax: (44) 1223-416-300 CEO: Dr. John Brown Research director: Dr. Philip Bedford R&D expertise: Research, development and manufacture of novel drugs and vaccines in the areas of immune function disorders, inflammation, infectious disease, cardiovascular disease, etc. Joint ventures: Medical research council (protease inhibitors, antibacterials); Peptimmune (protease inhibitors, asthma); Oravax (acquisition); Pasteur Merieux Connaught (vaccines).

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R&D collaboration: Medeva (non-injectable vaccines); Eli lilly (protease inhibitors); Novartis (protease inhibitors). Key license and trade contracts: SmithKline Beecham (allergy vaccine); Pfizer (allergy vaccine — veterinary application). Technological expertise: CC, E, Q, F, PA, P/S, HTDS, RD, SMC, SY, G, H/CF, BI, C/TC, COC, CH/S, DD, D-D, GA Main products/instrumentation under R&D: Yellow fever vaccine, Phase III/IV; Allergy vaccine, Phase III; Oral Typhoid vaccine, Phase III, H. Pylori vaccine, Phase III; Rye Grass tolerising peptide, Phase III; Oral ETEC vaccine, Phase II; C. difficile antitoxin, Phase II; Veterinary allergy vaccine, Phase II; Oral H. Pylori vaccine, preclinical; Japanese encephalitis vaccine, preclinical. Subsidiary bodies: Oravax (Cambridge, MA).

2185

PEPTISYNTHA et CIE SNC

681

NDA submitted; peptide synthesizer, peptide sequencer, peptide T, peptidase A isozyme. Sealed and granted patents: In the domain of peptide synthesis.

2186

PEPTOR, LTD.

Add: Science-Based Industrial Park Kiryat Weizmann, P.O. Box 43, Rehovot 76326, Israel Tel: (972) 8-978-7704 Fax: (972) 8-940-7737 E-mail: [email protected] Web site: www.peptor.co.il President/CEO: Dr. Yoram Karmon R&D expertise: Development, manufacture and marketing of synthetic peptides and peptidomimetic-based pharmaceuticals for target indications such as asthma, osteoporosis and certain cancers. Synthesis of peptides with fixed, known conformations through a patentpending “Cyclization Technology”.

Add: 310 rue de Ransbeek, B-1120 Brussels, Belgium

Technological expertise: PIS, PS, PS/AP, P/PS

Tel: (32) 2-4075-8111

Principal products/instrumentation: Synthetic peptides, contract research/manufacture products.

Fax: (32) 2-2645-2735 E-mail: [email protected] [email protected]

;

Web site: www.peptisyntha.com

Main products/instrumentation under R&D: Peptidomimetic-based pharmaceuticals, cyclization technology peptide antibiotics, peptide nucleic acid.

President: A. Hoffait Research director: G. Blondeel Subsidiary of Solvay SA. R&D expertise: Peptides and peptide instrumentation, other biotechnology medicines development/manufacture. Technological expertise: CS, PIS, CC, SY, P, PI Principal products/instrumentation: GMP Custom Synthesis, large-scale(> 1kg) (pilot and industrial scale)/Industrial HPLC. Main products/instrumentation under R&D: At all stages, preclinical, Phase I, II, III and

2187

PERCELL BIOLYTICA AB

Add: Ji-Te Gatan 9, S-265 38 Astorp, Sweden Tel: (46) 42-502-82 Fax: (46) 42-501-91 E-mail: [email protected] Web site: www.percell.se President/CEO: Kjell Nilsson R&D expertise: Development and production of biomatrices and microcarriers.

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Technological expertise: C/TC

President: John Moore

Principal products/instrumentation: Cultispher-S, Cultispher-G, Cultispher-GL.

Research director: Molly Redenbaugh

Main products/instrumentation under R&D: Biomatrices, microcarriers.

2188

PERCEPTIVE SCIENTIFIC INSTRUMENTS, INC.

R&D expertise: R&D and manufacture of environmental control chambers, biological control chambers, biological incubators, plant tissue culture and growth chambers, pharmaceutical testing chambers, etc. Technological expertise: C/TC, BME

Research director: Kenneth R. Castleman, Ph.D.

Principal products/instrumentation: Arabidopsis plant growth chambers AR-33L, AR36L, AR-66L, AR-75L; Plant tissue culture chambers CU-36L, CU-36L3, CU-3665; Biological incubators I-30, i-33 series, I-36 series, I-66 series; Plant growth chambers E30 series, E-30LED, E-33L, E-36L, E-75A, RE-9, RE-16; Pharmaceutical testing chambers RX3000, RX3000L, RX3600, RX3600L, RX6600.

Subsidiary of International Remote Imaging Systems.

Main products/instrumentation under R&D: Biological control chambers.

Add: 2525 South Shore Blvd., Suite 100, League City, TX 77573 Tel: (713) 334-3027 Fax: (713) 334-3116 President/CEO: Tony Landells

R&D expertise: R&D and manufacture of products for cytogenetics and molecular cytogenetics. Technological expertise: C/TC, CH/S, G, AU

2190

PERFORMANCE PLANTS, INC.

Principal products/instrumentation: GenetiScanner Automatic Metaphase Finder, TeachTech, Genetiscan Lab Manager System, PowerGene Karyotyping System, PowerGene Probe System, PowerGene CGH, PowerGene MFISH, FISH.

Add: 700 Gardiners Road, Kingston, ON K7M 3X9, Canada

Main products/instrumentation under R&D: Cytogene, molecular cytogene.

President/CEO: Dr. David Dennis

Subsidiary bodies: Perceptive Scientific International Ltd., Chester, U.K.

R&D expertise: R&D of agricultural biotechnology, focused on the improvement of metabolism in major crop species to improve output traits; products manufacture.

2189

PERCIVAL SCIENTIFIC, INC.

Add: 505 Research Drive, Perry, Iowa 50220 Tel: (515) 465-9363 Fax: (515) 465-9464 E-mail: [email protected] Web site: www.percival-scientific.com

Tel: (613) 545-0390 Fax: (613) 545-3618 Web site: www.performanceplants.com Research director: Dr. Daniel Lefebure

R&D collaboration: Dow Agrosciences Canada; Agriculture and Agrifood Canada; University of Toronto; University of Guelph. Key license and trade contracts: Dow Agroscience Canada. Technological expertise: E, F, RD, G, Q, T, AB, CB, C/TC

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Principal products/instrumentation: Agriculture, bioremediation, environmental control products, nutraceuticals, growth enhancement technology (GET), augmented microbial and plant expression (AMPLE). Main products/instrumentation under R&D: Drought tolerance; improved phosphorus metabolism; improved carbon metabolism, nutraceuticals. Subsidiary bodies: Saskatoon Research Facility. Sealed and granted patents: U.S. 08/568,168; U.S. 08/747,788; U.S. 08/804,794.

2191

PERI DEVELOPMENT APPLICATIONS

Technological expertise: AF, DD, P, PPAT, PS, PS/AP, P/PS Main products/instrumentation under R&D: Anti-microbiai peptides to treat periodontal disease, two products in Phase III clinical trials. Controlled release drug delivery system containing anti-microbial agent that delivers agent to infected pocket or surgical site for up to 30 days. Sealed and granted patents: Patents issues on peptide technologies, patents filed on all other technologies.

2193

PERKIN ELMER INSTRUMENTS

Add: 761 Main Ave. Norwalk, CT 06859

Add: P.O. Box 6, Beit Dagan 50250 Israel

Tel: (203) 762-4000

Tel: (972) 3-968-3696

Fax: (203) 762-4228

Fax: (972) 3-960-4044

E-mail: [email protected]

R&D expertise: Technology transfer of related products in field and garden crops, horticulture, animal science, plant protection, soil and water technology storage of agricultural products and agricultural engineering, etc.

Web site: www.perkinelmer.com

Technological expertise: C/TC, G Main products/instrumentation under R&D: Contract technology transfer products, plant growth regulator, plant protection agents.

2192

PERIODONTIX, INC.

Add: 313 Pleasant St., 4th Floor Watertown, Massachusetts 02472 Tel: (617) 926-1980 Fax: (617) 926-4776 President/CEO: Robert B. Linke Research director: Phillip Friden, Ph.D. R&D expertise: Development and manufacture of biopharmaceuticals for periodontal diseases.

683

President: Dr. Robert J. Rosenthal Subsidiary of PerkinElmer, Inc. R&D expertise: R&D and manufacture of analytical and life science system used in biotechnology, pharmaceuticals, enviromental testing, food, agriculture and chemical manufacturing, etc. Technological expertise: E, Q, AB, CH/S, GA, HTDS, PIS, P/S, RD, SY, ET, BTS, CB Principal products/instrumentation: HTS700™ BioAssay Reader, AAnalyst™ 100 & 300 Atomic Absorbtion Spectrometers, IdentiCheck™ FT-NIR System, AutoIMAGE™ FT-IR Microscope, Pyris 1™ Differential Scanning Calorimeter, Lambda Bio 10, 20 & 40 UV/VIS Specrometers, Turbochrom™ Client/Server Chromatography Data System, SQLPROTOCOL™ Software, AutoSystem XL™ Gas Chromatograph, Voyager™ Portable Gas Chromatograph, Series 200 MS HPLC System, API 365 LC/MS/MS System, ELAN® 6000 ICP-MS, Optima™ 3000 ICP-OES,

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GeneAm®p PCR System 9700, ABI PRISM™ 770 Sequence Detection System, ABI PRISM 377 DNA Sequencer, ABI PRISM™ 877 Intergrated Thermal Cyler, PCR Reagents (AmpliTaq Gold™ PCR Enzyme).

2194

PERKIN ELMER LIFE AND ANALYTICAL SCIENCES

Add: 940 Winter Street, Waltham, MA 02451

R&D expertise: Development and manufacture of laboratory research detection equipment. Technological expertise: BI, D-D, G, HTDS, PIS, R Principal products/instrumentation: Detection systems for HTS, Screening labs, Microbeta, Viewlux, Laboratory research novel detection equipment.

2196

PERMA-PIPE, INC.

Tel: (203) 925-4602 E-mail: [email protected] Web site: www.perkinelmer.com President: Jeff Ronner Subsidiary of Perkin Elmer. R&D expertise: Life sciences research, related novel products development.

Add: 7720 North Lehigh Ave. Niles, Illinois 60714 Tel: (847) 966-2235 Fax: (847) 470-1204 E-mail: [email protected] Web site: www.permapipe.com

Key sales market contracts: EG&G Berthold; Tomtec, Inc; Hidex Oy; Apricot

President: Fati Elgendy

Technological expertise: HTDS, G, BME

R&D expertise: Development and manufacture of pre-insulated and secondary contained piping system plus leak detection/location, cathodic protection, heat tracing.

Principal products/instrumentation: 1420 Victor Multi-Label Reader; 1205 Betaplate; 1450 Microbeta Trilux Mircroplate Beta, Gamma and Luminescence Counter for drug screening, Bioassays; 1414 Win Spectral Line of LSC’s; 1470/1480 Wizard Gamma Counters, Berthold Luminometer; UltraVIEW™ Confocal Imaging System; NightOWL™ Imager, ViewLUX™, NightOWL™; ARTHUR™ Fluoroimager, ARTHUR™.

2195

PERKIN ELMER WALLAC GMBH

Subsidiary of MFRI, Inc.

Technological expertise: BME Main products/instrumentation under R&D: Contract R&D products, secondary contained piping system. Subsidiary bodies: Manufacture. facility in Lebanon, TN.

2197

PURITROL, INC.

Add: 70 Bernard Cir, Centerville, MA 02632 Add: Jechtinger Strasse 9 Freiburg 79111 Germany Tel: (49) 767-455-490 Fax: (49) 767-455-4929 E-mail: [email protected] CEO: Rainer Ehni Subsidiary of Perkin Elmer Life Sciences.

Tel: (508) 420-2435 President/CEO: Thomas P. Murphy Research director: Debra J. Saez, Ph.D. R&D expertise: R&D and manufacture of bioscience industry product, includes drug synthesis, purification, biosensors, medical devices, scale-up, WFI validation and design.

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Technological expertise: F, Q, E, P/S, BA, PMC, SY, BME

Key sales market contracts: Boehringer Mannheim.

Main products/instrumentation under R&D: Biomembranes, biosensors, drug synthesis and purification devices.

Technological expertise: CS, SS, P, P/S, BP, PMC, PI, PIS, PS

2198

PERPETUAL ENVIRONMENTAL, LTD.

Add: Hayden Farm Hayden Lane Nuffield Henley on Thames, Oxon RG9 STX U.K. Tel: (44) 1491-641-945 Fax: (44) 1491-641-923 R&D expertise: R&D and manufacture of environmentally better cleaners; Environmental clean-up kits and remediation and insurance = 10M plus. Technological expertise: DK, BS, BME Principal products/instrumentation: Carpet cleaner deodoriser, Liquisol™; Body Spill Kits, Solid Solution™;Blood Spill Gel, Absorba Gel™, Graffiti Removers, Plex™. Main products/instrumentation under R&D: Drain treatments, market testing, environmental clean-up kits, environment cleaners.

Principal products/instrumentation: Matrix Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF); Electrospray; chromatography, PEG-PS™ supports, activation chemical (HOAT, TFFH, HATU, etc., reagents), ally-based amino acid, 9050 plus™ peptide synthesizer, Pioneer™ peptide synthesis system. Main products/instrumentation under R&D: Peptide synthesis reagents and peptide synthesis instrumentation. Subsidiary bodies: Houston, TX; Cambridge, MA; San Francisco, CA; Wiesbaden, Germany; Tokyo, Japan; Paris, France; Hertsford, U.K. Sealed and granted patents: Perfusion chromatography technology media and systems delayed extraction — over 75 total patents.

2200

MOFET B’YEHUDA INNOVATION ACCELERATOR

Add: P.O. Box 80, Kiryat Arba 90100, Israel Tel: (972) 2-996-3880

2199

PERSEPTIVE BIOSYSTEMS, INC.

Add: 500 Old Connecticut Path, Framingham, MA 01701

Fax: (972) 2-996-1571 Web site: www.greentech.co.il Research director: Dr. Daniel Vigdarovitch

Tel: (508) 383-7700

R&D expertise: Rose oil developmentment, design and production.

Fax: (508) 383-7880

Technological expertise: C/TC

President/CEO: Noubar B. Afeyan, Ph.D.

Main products/instrumentation under R&D: Products of rose oil in cultured plant cells, first stages of R&D.

Research director: Steve Nurnburg, Ph.D. R&D expertise: Development and manufacture of peptide and peptide instrument for mass spectrometers specializing in matrix-asissted laser desorption TOF-MS and biospectrometers, chromatography instruments and media, synthesis instruments and chemistry, PNA.

2201

PFALTZ & BAUER, INC.

Add: 172 East Aurora St. Waterbury, CT 06708

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Tel: (203) 574-0075

E-mail: [email protected]

Fax: (203) 574-3181

Web site: www.ferro.com

E-mail: [email protected]

President: George Holstein III

Web site: www.pfaltzandbauer.com

Research director: Kenneth Thomson, Ph.D.

President/CEO: Mark Halperin

R&D expertise: R&D and manufacture of carbohydrates and derivatives, pharmaceutical intermediates, diagnostic chemicals and research biochemicals.

R&D expertise: Development/manufacture of fine chemicals and research chemicals. Principal products/instrumentation: Biologicals, fine chemical and research chemicals, natural products, nutraceuticals, reagents.

Key sales market contracts: Cambridge Research Biochemicals. Technological expertise: LP, P/S, SY, CB, CS

2202

FERRO PFANSTIEHL EUROPE, LTD.

Add: Pfanstiehl House 3l Pritchard Dr. Davenham, Cheshire CW9 8HL U.K.

Principal products/instrumentation: Specialty chemicals, biologicals, diagnostics. Main products/instrumentation under R&D: Carbohydrate derivatives, pharmaceutical intermediates, research biochemicals.

Tel: (44) 1606-559-163 Fax: (44) 1606-559-641

2204

PFEIFFER VACUUM, INC.

Web site: www.ferro.com CEO: Dr. David B.

Add: 24 Trafalgar Sq. Nashua, NH 03063

R&D expertise: Development of carbohydrates and related biochemicals process development and scale-up, contract manufacture.

Tel: (603) 578-6500

Key sales market contracts: Pfanstiehl Laboratories, Inc. (Waukegan, II)

Web site: www.pfeiffer-vacuum.com

Technological expertise: CC, SY, P/S, SMC, CB Principal products/instrumentation: Sugars and carbohydrates, lactic acid and lactates, creatine, phospholipids, blocked sugars, nucleosides and derivatives, carbohydrate reference standards, specialty chemicals.

2203

FERRO PFANSTIEHL LABORATORIES, INC.

Add: 1219 Glen Rock Ave. Waukegan, IL 60085

Fax: (603) 578-6550 E-mail: [email protected] President: Wolfgang Dondorf R&D expertise: R&D and manufacture of pumps, instruments and detectors for drug research. Technological expertise: PMC, BME Principal products/instrumentation: Turbomolecular and mechanical vacuum pumps; analytical instruments; gas analyzers; leak detectors. Main products/instrumentation under R&D: Detectors for drug research.

2205

PFIZER, INC.

Tel: (800) 383-0126

Add: 235 E. 42nd St. New York, NY 10017

Fax: (847) 623-9173

Tel: (212) 573-2323

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Fax: (212) 573-7851 Web site: www.pfizer.com President: Edward C. Bessey Research director: John F. Niblack R&D expertise: Discovery, research and development of biotechnological medicines and innovative health care products. R&D collaboration: Genzyme — orthopedic products utilizing hyaluronic acid technology, Calgene — genetically engineered plants. Alamar Biosciences — antifungal susceptibility, AEA Technology — drug discovery based on genomics research. Key sales market contracts: Advanced Polymer Systems — microsponge technology. Technological expertise: DD, D-D, ET, AB, C/TC Principal products/instrumentation: Liquid xanthan biopolymer for EOR, Fermentation scale-up and production services, Specialty Chemicals for AIDS therapeutics, selzentry maraviroc for use in combination with other antiretroviral drugs for the treatment of adults with CCR5-tropic HIV-1,who have been treated with other HIV medications and who have evidence of elevated levels of HIV in their blood (oral), 2007; sunitinib malate (Sutent), treatment of gastrointestinal stromal tumor, 2006; varenicline (Chantix), as an aid to smoking cessation, 2006; Pregabalin (Lyrica), management of neuropathic pain associated with diabetic peripheral neuropathy, 2004. Main products/instrumentation under R&D: Drug discovery technology based on genomics research, ticiclmumab, treat melanoma, Phase III, 2008; VEGF responsive cell based assay, stabilized granulocyte colony stimulating factor. Sealed and granted patents: Mycoplasma hyopneumoniae vaccine and methods for reducing mycoplasme bovis pneumonia in cattle. 7,056,492, U.S.; Directing the ratio of B2: B1 avermectins in Streptomyces avermitilis

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host cells. 6,632,673, U.S.; Stereoselective microbial reduction of a racemic tetralone. 6,589,777, U.S.; Canine coronavirus S gene and uses therefore. 6,372,224, U.S.; VEGF responsive cell-based assay for determining VEGFbioactivity. 6,787,323, U.S.; Proteins from actinobacillus pleuropneumoniae. 6,713,071, U.S.; Method for the purification, recovery, and sporulation of cysts and oocysts. 6,984,378, U.S.; Stabilized granulocyte colony stimulating factor. 6,497,869, U.S.; Assays for measurement of type IIcollagen fragments in urine. 6,642,007, U.S.

2206

PHARMA BIO-RESEARCH INTERNATIONAL B.V.

Add: Science Park, NL-9471 GP, Zuidlaren, The Netherlands Tel: (31) 50-402-2222 Fax: (31) 50-402-2223 President/CEO: Prof. Dr. J. H. G. Jortkman Research director: B. Wilffert, Ph.D., RPh. R&D expertise: Fundamental and applied clinical R&D and laboratory services for the pharmaceutical and biotechnological industry enterprise drug products. Joint ventures: Pharma Sciences International B.V., Academic Hospital Groningen, Martini Hospital Groningen, Wilhelmina Hospital Assen, University Medical School Debrecen (Hungary), Mahidol University/Faculty of Tropical Medicine (Thailand), Macha Mission Hospital, Malaria Institute (Zambia), Institute of Medical Research and Study of Medicinal Plant (Cameroon). Technological expertise: CC, E, DD, D-D, GA, P/S, R Principal products/instrumentation: High quality pharmaceutical, clinical pharmacology and bioanalytical research programs; clinical research facility specializes in long-term dose tolerance studies (up to 40 days in-clinic);

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pharmacokinetic/pharmacodynamic and mass balance research programs (with 14C-labeled drugs) in phenotyped healthy young volunteers (pool of 5,000 subjects, mostly university students) and healthy elderly volunteers(pool of 500); Also experience with patient-studies (Phase III and Phase IV and special groups, e.g., HTV, malaria, benign prostate hyperplasia, epilepsy, renal failure, liver failure, postmenopausal, diabetes); radiolabelled drugs. Modern laboratory analytical apparatus, including two laboratory robots and four SciexAPILC-MS/MS, forbio-analysis, isotope analysis, clinical chemistry and pharmaceutical analysis equipment. Main products/instrumentation under R&D: Several biotechnological drugs and vaccines in Phases I–III. Sealed and granted patents: Many patents pending.

Principal products/instrumentation: Contract research/clinical trial products, diagnostics, natural products, pharmaceuticals, Technosphere™ Drug Delivery (oral, pulmonary, parenteral, implantable); Photo-Diagnostic™ (Fluorescence Diagnostic Technology). Main products/instrumentation under R&D: Novel Drug Delivery Systems; Novel Fluorescent Diagnostic Technologies, Alzheimer’s drugs. Sealed and granted patents: Technosphere™ Drug Delivery; Photofluor™ Fluorescent Diagnostics; Alzheimer’s Drug.

2208

PHARMACEUTICAL RESEARCH ASSOCIATES, INC.

Add: 8300 Greensboro Dr # 400; Mc Lean, VA 22102 Tel: (703) 748-0760 Web site: www.pra-ww.com

2207

PHARMACEUTICAL DISCOVERY CORP.

President/CEO: Earle Martin Research director: Bruce Teplitzley

Tel: (914) 345-8600

R&D expertise: Clinical CRO, contract novel drugs development and manufacture.

Fax: (914) 345-9346.

Technological expertise: CH/S, CW, COS

President: George S. Goldstein, M.D.

Principal products/instrumentation: Contract research/clinical trial products.

Add: 33 West Main St., Elmsford, NY 10523

Research director: Christopher A. Rhodes, Ph.D. R&D expertise: R&D of novel drug delivery technologies, CNS/OV Pharmaceuticals, fluorescence-based drug discovery and diagnostics, combinatorial and medicinal chemistry, related novel products manufacture. Joint ventures: Boehringer-Ingelheim Pharmaceuticals, Inc. (U.S.A.), Boehringer-Ingelheim GmbH, Carter-Wallace, Inc. R&D collaboration: Boehringer Ingelheim GmbH, Carter-Wallace, Inc. SmithKline Beecham. Technological expertise: SY, AB, COC, CH/S, DD, D-D, GT, HTDS, P/S, SMC CC

2209

PHARMACIA & UPJOHN

Add: 7000 Portage Rd., Kalamazoo, MI 49001-0199 Tel: (616) 833-4000 R&D expertise: R&D of biopharmaceuticals and Pharmaceutical Intermediates; related novel products manufacture. Technological expertise: F, Q, BA, C/TC, DD, PMC, P/S, RD, SY, S Principal products/instrumentation: Genotropin™ (somatropin for injection), recombinant

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human growth hormone for praderwillisyndrome, short stature in children due to growth hormone deficiency; Fragmin; Contract manufacturing products, Somavert(Pegvsomant) for the treatment of acromegaly in patients who have an inadequate response to surgery and/or radiation therapy and/or other medical therapies, or for whom these therapies are not appropriate, 2008. Main products/instrumentation under R&D: CDTect™ marker for alcohol abuse; UniCAP Allergy Diagnostic System; thrombopoietin (TPO) for treatment of myelosupression, myeloblation, Phase III, 2008; trecetilidefumarate (LHRH antagonist) for atrial arrhythmia, Phase III, 2008. Sealed and granted patents: Alzheimer’s disease secretase, APP substrates therefore, and uses thereof. 7,041,473, U.S.; Method of identifying agents that inhibit APP processing activity.6,706,485, U.S.; Method for autoactivation of procaspase.6,303,329, U.S.; Human sel-10polypeptides and polynucleotides that encode them. 6,638,731, U.S.; Autoregulatory system for validation microbial genes as possible antimicrobial targets using a tetracyclinecontrollable elements. U.S.; Pseudoraies virus protein. 6,261,563, U.S.; method of vaccinating vertebrates. 7,160,544, U.S.

2210

PHARMACOGNETICS, INC.

Add: 6225 Hampstead Ct, Port Tobacco, MD 20677-3427 Tel: (301) 934-3700 Fax: (301) 753-3268 President: Neil A. Belson Research director: Neil A. Belson R&D expertise: Natural products development; agricultural biotechnology research, related novel products manufacture. Technological expertise: SY

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Main products/instrumentation under R&D: Treatment for zebra mussels and aquatic nuisances; anti-inflammatory natural products, method for detecting single nucleotide polymorphisms. Sealed and granted patents: Zebra mussel treatment; Method for detecting single nucleotide polymorphisms (SNP’s) and point mutation. 692,174, U.S.

2211

PHARMACOPEIA, INC.

Add: 10275 Science Center Drive, San Diego, CA 92121 Tel: (858) 550-7500 E-mail: [email protected] Web site: www.pharmacopedia.com President/CEO: Joseph A. Mollica, Ph.D. Research director: Jack Baldwin, Ph.D. R&D expertise: R&D of drug discovery using combinatorial chemistry, high throughput screening and informatics; related novel products manufacture. R&D collaboration: Schering Plough Corporation; Berlex Laboratories, Inc.; Bayer Corporation; Novartis, Daiichi Pharmaceutical Co., Ltd.; Akzo-Nobel/NV Organon, Zeneca, Regeneron Pharmaceuticals, Cubist Pharmaceuticals, Idun Pharmaceuticals, Mitotix, Bristol-Myers Squibb, Texas Biotechnology, Progenics, Alexion, Ribogene, Neurocrine, Cytomed. Technological expertise: SMC, COC, CH/S, D-D, HTDS, BI, SY Main products/instrumentation under R&D: Potential drug candidates in the areas of cancer, obesity, allergy, autoimmunity, osteoporosis, inflammation, cardiovascular, HIV, pain, malaria, transplantation and retinopathy — all programs in research stage; cooperative drug discovery projects with Akzo Novel/NV Organon, Berlex Laboratories, Bristol-Myers

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Squibb, Otsuka Pharmaceutical Factory, Progenics, Roche, and Schering-Plough Corporation built on Pharmacopeia’s medicinal chemistry, combinatorial chemistry, assay development, high throughput screening, computational tools, and informatics technologies, in collaborative projects and internal discovery projects against targets covering a number of therapeutic areas including inflammation, cancer, and CNS; Small molecule, drug-like compounds suitable for development as orallyactive therapeutics; a variety of cell lines including primary or recombinant; Screening Systems, including high throughput and ultrahigh throughput systems using 384-well and 1536-well micro-plates. Advanced submicroliter fluid handling and optical detection. Chemistries: Radiometric and fluorometric. Subsidiary bodies: 2000 Cornwall Rd., Monmouth Junction, NJ 08852, (Research and development facilities); 3000 Eastpark Blvd., Cranbury, NJ 08512. Sealed and granted patents: ECLiPS™ Tagging technology; Method for maintenance and selection of episomes.6,417,002, U.S.; other patents pending.

2212

PHARMADERM LABORATORIES, LTD.

Add: 343-111 Research Dr., Saskatoon, Saskatchewan, S7N 3R2 Tel: (306) 934-7471 Fax: (306) 934-7453 E-mail: [email protected]

2213

PHARMADULE AB

Add: Danvikcenter 28, SE-130 30 Nacka, Sweden Tel: (46) 8-5874-2000 Fax: (46) 8-5874-288 E-mail: [email protected] Web site: www.pharmadule.com President: Thomas Wangberg R&D expertise: Contract R&D and supply of pharmaceutical and biotechnical equipment, e.g., LVP’s, SVP’s, mixtures, ointments and creams, tablets and capsules, laboratories for analytical and microbiological works, all in compliance with cGMP’s. Biotech plants; fermentation, purification downstream processing. Joint ventures: Pharmadule, Pharmacia Biotech. Technological expertise: F, PA, T, BA, BS, C/TC, PMC, P/S Principal products/instrumentation: Contract manufacturing products, biopharmaceuticals, various pharmaceuticals. Main products/instrumentation under R&D: Purification downstream processing, biotechnical equipment. Subsidiary bodies: Pharmadule Inc., 10518 NE 68th St, Kirkland, WA 98033, U.S.A., Tel: (425) 822 8413, Fax: (425) 822 4850; Pharmadule China, Kuen Yang International Business Plaza, Suite 1506, No. 798 Zhaojiabang Lu, P.C. 200030 Shanghai, P. R. China, Tel: (86) 21-64-66-8206, Fax: (86) 21-64-66-8205.

President: Dr. Marianna Folduari Research director: Dr. Marianna Folduari R&D expertise: Biopharmaceuticals and drug delivery systems development/manufacture. Technological expertise: H/CF, C/TC, DD, D-D Principal products/instrumentation: Contract R&D products, biopharmaceuticals, drug delivery system.

2214

PHARMADULE, INC.

Add: 500 Hills Drive., STE 120, Bedminster, NJ 07921 Tel: (908) 470-1023 Fax: (908) 470-1024

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E-mail: [email protected] Web site: www.pharmadule.com President: Henry G Kuhiman Subsidiary of Pharmadule AB, Sweden R&D expertise: Development of turnkey biotech and pharmaceutical process facilities, related novel products manufacture. Technological expertise: F, PA, T, GT, BA, BS, C/TC, PMC, P/S Principal products/instrumentation: Contract manufacturing products, biopharmaceuticals, vaccines, veterinary products.

2215

ASTERAND (EUROPE)

Add: 2 Orchard Road Royston, Herts SG8 5HD, U.K. Tel: (44) 1763-211-600

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Research director: Jorge Alemany Herrera Subsidiary of Zeltia Group. R&D expertise: Development and manufacture of anti-tumor/HIV/malaria compounds. R&D collaboration: Various universities and research centers in Spain and other parts of the world. Key license and trade contracts: CVL; Innovations Foundation Technological expertise: Q, SMC, RD, GA, CS, P/P Principal products/instrumentation: Antitumor compounds, Anti-HIV compounds; Anti-malarial, compound. Main products/instrumentation under R&D: New systems for the detection of nucleic acids. Subsidiary bodies: PharmaMar U.S.A., Cambridge, MA; PharmaMar (Leon), Leon, Spain.

Fax: (44) 1763-211-555 E-mail: [email protected]

2217

Web site: www.asterand.com President/Chairman: Dr. Nowell Stebbing Research director: Dr. Gordon Smith Baxter R&D expertise: Novel drug discovery preclinical research services, focusing on the use of human biomaterials. Technological expertise: Q, BI, C/TC, GA, PG, RD Principal products/instrumentation: Contract research/clinical trial products, pharmaceuticals, human biomaterials.

2216

PHARMAKINETICS LABORATORIES, INC.

Add: 302 West Fayette St. Baltimore, MD 21201 Tel: (410) 385-4500 Fax: (410) 385-1957 President/CEO: James K. Leslie Research director: James W. Wilkinson, Ph.D. R&D expertise: Contract research of novel drug development. Joint ventures: Aster, Cephac. Technological expertise: SMC, PC, CW, COS Principal products/instrumentation: Contract research/clinical trial products, pharmaceuticals.

PHARMA GEN S.A. 2218

Add: C/De La Calera, 3 Tres Cantos Madrid 28760 Spain

PHARMAKON EUROPE

Tel: (34) 1-803-7575

Add: Les Oncins B.P.0118 69593 L’ArBresle Cedex, France

Fax: (34) I-803-1143

Tel: (33) 7-401-6363

President: Jose Maria Femandez-Sousa Faro

Fax: (33) 7-401-6399

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President: Leif Modeweig, D.V.M

Tel: (415) 472-2181

Research director: Michel Virat, D.V.M.

Fax: (415) 472-2183

Subsidiary of DNX CORP.

E-mail: [email protected]

R&D expertise: Research of efficacy and safety preclinical testing to biopharmaceuticals.

Web site: www.pharmalogic.com

Technological expertise: E, T, C/TC

R&D expertise: Pharmaceuticals and biomedical devices development, manufacture and licensing.

Main products/instrumentation under R&D: Biodigm™ transgenic animal models of human disease condition to evaluate potential therapeutics, efficacy and safety preclinical testing method to biopharmaceuticals. 2219

President/CEO: Gary Novack, Ph.D.

Technological expertise: D-D, DD, CH/S, BME Principal products/instrumentation: Pharmaceuticals, vaccines, reagents, antibodies, biomedical devices, antigodies, contract R&D products.

PHARMAKON RESEARCH INTERNATIONAL, INC. 2221

PHARMAMAR S.A.

Add: P.O. Box 609 Waverly, PA 18471 Tel: (717) 586-2411 Fax: (717) 586-3450. President: Leif Modeweg, D.V.M. Research director: Vincent B. Ciofalo, Ph.D.

Add: Avda. De los Reyes, 1, Pol. Ind. La MinaNorte, 28770-Colmenar Viejo, Madrid, Spain Tel: (34) 91-846-6000 Fax: (34) 91-846-6001

Subsidiary of DNX CORP.

E-mail: [email protected]

R&D expertise: Cell and tissue culture research, efficacy and safety preclinical testing of biotechnology medicines, detect the potential genetic effects of chemical agents.

Web site: www.pharmamar.com

Technological expertise: E, T, C/TC, ERT Main products/instrumentation under R&D: Biodigm™ transgenic animal models of human disease condition to evaluate potential therapeutics, efficacy and safety preclinical testing method to biopharmaceuticals. Subsidiary bodies: Pharmakon, Europe: Lis Oncins B.P. 0118 69593 L’Arbresle CEDEX, France, Tel: (33) 7401-6363, Fax: (33) 74016399. 2220

PHARMALOGIC DEVELOPMENT, INC.

Add: 17 Bridgegate Dr., San Rafael, CA 94903-1093

President: Jose Maria Femandez-Sousa Research director: Jose Luis Fernandez Puentes R&D expertise: Research and development of new drugs from marine sources, related novel products manufacture. Key license and trade contracts: University of Illinois. Technological expertise: F, P/S, BA, C/TC, PMC, SY Main products/instrumentation under R&D: Antitumor compounds (1 Phase II, 2 IND filing, 10 preclinical); Anti-malarial compounds (2 IND filing ), novel marine drugs.

2222

PHARMAPART AG

Add: Bahnhofstrasse 20 Postfach 8800 Thalwil, Switzerland

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2224

693

PHARMASYN, INC.

Fax: (41) 44-723-5960 E-mail: [email protected] Web site: www.pharmapart.com President: Stephan Henauer, M.D. Research director: Dr. S. Henauer R&D expertise: R&D and manufacture of novel biopharmaceuticals. Technological expertise: C/TC, DD, D-D Principal products/instrumentation: Contract research/clinical trial products, natural products, nutraceuticals, pharmaceuticals, vaccines, veterinary products. Main products/instrumentation under R&D: Novel biopharmaceuticals.

Add: 1840 Industrial Dr. Ste 140, Libertyville, IL 60048 Tel: (847) 918-9018 Fax: (847) 918-1610 President: John Pierpont R&D expertise: Custom R&D/manufacturing of fine organic compounds for the pharmaceutical industry. Technological expertise: P/S, SMC, SY Principal products/instrumentation: Custom synthesis products, specialty chemicals. Main products/instrumentation under R&D: Fine organic compounds, fine particle.

2225 2223

PHARMA VENTURES, LTD.

NNE PHARMAPLAN

Add: Vandtarnsvej 108-110, 2860 Soborg, Denmark

Add: Magdalen Centre, Oxford, OX4 4GA, U.K. Tel: (44) 1865-784-177

Tel: (45) 4444-7777

Fax: (44) 1865-784-178

Fax: (45) 4444-3777

E-mail: [email protected]

Web site: www.nnepharmaplan.com

Web site: www.pharmaventures.com

CEO: G. Jakobi

President: Fintan Walton, Ph.D.

Subsidiary of Fresenius.

R&D expertise: Consultancy in the biotechnology, healthcare, pharmaceutical and finance sectors, conducting assignments in the following areas: technology and product portfolio assessment; market/competitor evaluation; company analysis; strategy formulation (market entry, alliances, financing); business plan preparation/critique; deal benchmarking, structuring and negotiation; expert reports/due diligence to support financing, and product and partnering identification, contract and negotiation.

R&D expertise: Consulting of new drug discovery, process engineering, product supplies for the pharmaceutical industry. Joint ventures: Hatch. Technological expertise: F, P/S, BA, BS, C/TC, PMC Principal products/instrumentation: Biomaterials, diagnostics, instrumentation, natural products, pharmaceuticals, process validation, vaccines Main products/instrumentation under R&D: New drug discovery route, process engineering technology.

Technological expertise: BI, AB, CB, CSDP. Principal products/instrumentation: Biotechnology drug products, medical device.

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Main products/instrumentation under R&D: Healthcare medicines, identification of original plant.

2226

PHARMETRIX

Add: 1330 O’Brien Drive Menlo Park, California 94025, U.S.A. Tel: (650) 688-0100 Fax: (650) 688-0115 President: Jack L. Aronowitz

to mouse, rat and human cell surface antigens, mAbs and recombinant proteins for cell cycle, tumor suppressor and oncoprotein research, and baculovirus reagents for protein expression in insect cells, mAbs and recombinant proteins for mouse and human cytokine analysis. Main products/instrumentation under R&D: Reagents for clinical research and diagnosis, including CMV-based vectors for protein expression in mammalian cells. Subsidiary bodies: PharMingen GmbH, Hamburg, Germany.

Subsidiary of TCPI. R&D expertise: R&D of transdermal drug delivery, related products manufacture. Technological expertise: DD Main products/instrumentation under R&D: Transdermal Drug Deliveries, transdermal drug delivery systems, transdermal enhancer. Sealed and granted patents: Portfolio of Transdermal Drug Delivery Patents.

2228

PHARMING GROUP N.V.

Add: P.O. Box 451 Archimedesweg 4-2333 CN Leiden 2300 AL, The Netherlands Tel: (31) 71-5247-400 Fax: (31) 71-5247-445 E-mail: [email protected] Web site: www.pharming.com President/CEO: George J. M. Hersbach

2227

PHARMINGEN

Add: 10975 Torreyana Rd., San Diego, CA 92121 Tel: (877) 232-8995 Fax: (877) 325-9637 E-mail: [email protected] Web site: www.bdbiosciences.com President/CEO: Ernest Chun-Ming Huang, Ph.D. R&D expertise: Bioprocess engineering research, production of reagents for research in immunology, cell biology, and molecular biology, etc. Technological expertise: Q, RD, P/S, H/CF, C/TC, GA, AB, PC, PPAT, P/PS Principal products/instrumentation: Biologicals, reagents, monoclonal antibodies (mAbs)

Research director: F. R. Pieper R&D expertise: Research of medical needs through biopharmaceuticals produced in the milk of transgenic animals. Medical needs of therapeutic application in the area of genetic disorders, infectious diseases, tissue and bone damage, cardiovascular diseases, and surgery and trauma; related products manufacture. Joint ventures: Genzyme General to commercialize human alphaglucosidase. Technological expertise: E, Q, T, BA, GA, P/S, RD, PI, PIS, PPAT, PS, PS/AP Main products/instrumentation under R&D: hLF, preclinical; alpha-Glu, preclinical; hCell, preclinical; Human alpha-glucosidase, Phase II; Human lactoferrin, Phase II; Human collagen, preclinical; Human factor XIII, research; Human fibrinogen, research; Human CI esterase inhibitor, research.

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Subsidiary bodies: Pharming B.Y, The Netherlands; Pharming OY, Finland; Pharming Technologies B.V., The Netherlands; Pharming Intellectual Property B.Y, The Netherlands; Pharming Healthcare Inc., U.S.; Pharming N.V., Belgium. Sealed and granted patents: Production of recombinant polypeptides in the milk of transgenic animals.

695

E-mail: [email protected] Web site: www.pharmoscorp.com President: Stephen R. Streber R&D expertise: Design and formulation of novel, proprietary patented drugs to treat disorders of the eye and central nervous system (CNS) and a “site active” corticosteroid to treat ocular inflammation, manufacture patented drugs. Technological expertise: D-D, DDI

2229

PHARMOS CORP.

Main products/instrumentation under R&D: Patented drugs, “site active” corticosteroid drug.

Add: 99 Wood Avenue South, Suite 311, Iselin, NJ 08830 Tel: (732) 452-9556 Fax: (732) 452-9557

2231

PHARMQUEST.COM

E-mail: [email protected]

Add: 4030 Moorpark Ave., Ste. 220 San Jose, CA 95117

Web site: www.pharmoscorp.com

Tel: (408) 984-3400

President: Gad Riesenfeld, Ph.D.

Fax: (408) 984-0666

Research director: Dr. Anat Biegon

E-mail: [email protected]

R&D expertise: Pharmaceutical R&D in drug delivery technologies for ophthalmic, oncological, and neurological applications; related novel products manufacture.

Web site: www.pharmquest.com

Key sales market contracts: Bausch and Lomb Pharmaceuticals.

R&D expertise: Drug development, informatics research.

Technological expertise: DD, D-D

Technological expertise: D-D, BI, G, HTDS, CH/S, PG, DD

Main products/instrumentation under R&D: Loteprednol Etabonate, Phase I/II; Dexanabinol, Phase III; Tamoxifen, preclinical; LE-T, Phase III/IV; drug delivery technologies. Subsidiary bodies: Pharmos, Ltd. (Research facility), Weizmann Industrial Park, Rehovot, Israel 76326.

2230

PHARMOS, LTD.

President/CEO: Shankar G. Hemmady Research director: Dr. Seema J. Handu

Principal products/instrumentation: www. pharmquest.com™, drug development informatics, drug development programs.

2232

PHAROS, SA.

Add: Parc Scientifique Sart Tilman Seraing B-4102, Belgium Tel: (32) 4-366-0150

Add: Kiryat Weizmann Rehovot 76326, Israel

Fax: (32) 4-365-5103

Tel: (972) 8-940-9679

President: Joseph Martial, Ph.D.

Fax: (972) 8-940-9686

Research director: Michel Thiry, Ph.D.

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R&D expertise: Bioprocess engineering research, custom R&D and manufacturing of biopharmaceuticals, vaccines and recombinant proteins, etc. Major partners: SmithKline Beecham Biologicals (Belgium).

2234

PHENOMENEX, INC.

Add: 2411 Madrid Ave Torrance, CA 905011430 Tel: (310) 212-0555

R&D collaboration: SmithKline Beecham Bioph.

Fax: (310) 328-7768

Technological expertise: C/TC, F, P/S, BA, LP, RD, GMP, production fermentation.

Web site: www.phenomenex.com

Principal products/instrumentation: Biologicals, vaccines, enzymes, clinical batches, contract R&D products. Main products/instrumentation under R&D: Bioprocess engineering technologies, novel biopharmaceuticals, recombinant proteins.

2233

PHARSIGHT CORPORATION

E-mail: [email protected] President: Fasha Mahjoor Research director: Faizy Ahmed R&D expertise: R&D and manufacture of consumables for the biotech and pharmaceutical industries enterprises (HPLC, GC, SPE, CE, Gel Electrophoresis). Key sales market contracts: Phenomenex distributes, simpleGEL™, gel electrophoresis line, for Archidexin U.S.A., U.K., Canada, P. R. China, Germany, and New Zealand.

Add: 321 E. Evelyn Ave, 3rd Fl., Mountain View, CA 94041-1530

Technological expertise: CC, P/S, COC, CH/S, DKHC, HC, BME

Tel: (650) 314-3800

Principal products/instrumentation: HPLC columns, Synergi™ Max-RP; Synergi™ PolarRP; Guard column cartridge system, SecurityGuard™; Automated Column Selector, Synergi™; Model RC-200 Solvent Recycler offers advanced features for automation and GLP/GMP, 2007; Liquid Chromatography Columns, 2007; HPLC Column: The new Luna® PFP(2) (pentafluorophenyl propyl) columns are high-performance columns that combine the advantages of Luna silica with the chemistry of a pentafluorophenyl for increased selectivity and reproducibility for difficult compounds, 2009; Column: A new 50 × 2.0 mm ID column has been added to the Onyx monolith line. The 30% smaller diameter column requires less sample volume and reduces solvent consumption. The Onyx columns, which contain solid rods of fused silica, produce results at high flow rates with low backpressure, 2009.

Fax: (650) 314-3810 E-mail: [email protected] Web site: www.pharsight.com President/CEO: Arthur Reidel Research director: Jaap Mandema, Ph.D. R&D expertise: Design/development of pharmaceutical and biotechnology to bring more competitive drugs to market, applies proprietary software technology and world-class consulting expertise to the scientific aspects of drug development to produce more successful and predictable outcomes. Technological expertise: CH/S, CB, D-D Principal products/instrumentation: Pharsight® trial designer; Win-Nonlin-Pro®; WinNonMix™. Main products/instrumentation under R&D: Competitive drugs, proprietary software technology. Subsidiary bodies: Gary, NC; Lexington, MA.

Sealed and granted patents: Patents held on stationary phases for HPLC packing materials.

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2235

PHILIPS ELECTRONIC INSTRUMENTS COMPANY

2237

697

PHOENIX IMPERATIVE, INC.

Add: 85 McKee Dr. Mahwah, NJ 07430

Add: 225 Corporate Blvd., Ste.204, Newark Delaware 19702

Tel: (201) 529-3800

Tel: (302) 366-0855

Fax: (201) 529-2252

Fax: (302) 366-1252

President/CEO: Bill Enser

President: Richard F. Geoghegan Jr.

R&D expertise: R&D and manufacture of electron microscopes. Technological expertise: BME

R&D expertise: R&D of pharmaceutical and biotechnology; related novel products manufacture.

Principal products/instrumentation: XL and CM series.

Technological expertise: PA, F, C/TC, PMC, P/S, BA, RD, GT, R

Main products/instrumentation under R&D: Electron microscopes.

Principal products/instrumentation: Engineering/Validation/Compliance Consulting systems, contract manufacturing products, contract research/clinical trial products, human genome project, reagents, antibodies, diagnostics, pharmaceuticals, process validation, vaccines.

2236

PHOENIX FLOW SYSTEMS, INC.

Add: 11575 Sorrento Valley Rd. #208 San Diego, CA 92121 Tel: (858) 453-5095

2238

Fax: (858) 259-5268

PHORTECH INTERNATIONAL

E-mail: [email protected]

Add: 238 Crestview Dr. San Carlos, CA 94070

Web site: www.phnxflow.com

Tel: (650) 594-0785

President/CEO: C. Kevin Becker

Fax: (650) 594-9846

Research director: Eric Pease

E-mail: [email protected]

R&D expertise: Development and manufacture of cell apoptosis and cell proliferation reagents for life sciences research.

Web site: www.phortech.com

R&D collaboration: Biochem.

CalBiochem/Nova-

Key sales market contracts: BD Pharmingen. Key license and trade contracts: New York Medical College. Technological expertise: H/CF, C/TC, CH/S, G Principal products/instrumentation: Cell detachment solution, cell dissociation solution. Main products/instrumentation under R&D: Cell apoptosis and cell proliferation reagents for life sciences research.

President: Michael J. Eby Research director: Michael J. Eby R&D expertise: R&D and manufacture of diagnostic kits, antibodies and antigens. Market research and technology assessment in the life sciences. Technological expertise: Q, BI, C/TC, CH/S, GA, P/S, R, MAE Principal products/instrumentation: Market research program including market size and share audits, new product concept tests, customer satisfaction studies, pre-post advertising research readership studies, distributor

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searches in North America, Europe, and the Far East. MSPPSA report series.

Web site: www.physitemp.com

Main products/instrumentation under R&D: Studies underway include amplification, sequencing, electrophoresis, chromatography, image analysis, molecular biology reagents, monoclonal antibodies, cell and tissue culture, cytokines and growth factors, and DNA diagnostics.

Research director: Christopher Proffitt

2239

PHOTON TECHNOLOGY INTERNATIONAL, INC.

Add: 300 Birmingham Road, P.O. Box 272, Birmingham, NJ 08011 Tel: (609) 894-4420 Fax: (609) 894-1579 E-mail: [email protected]

President/CEO: Ronald R. Feller R&D expertise: R&D and manufacture of scientists and researchers special-purpose instruments with precision temperature measurement equipment. Technological expertise: BME Principal products/instrumentation: BAT-10 and BAT-12 temperature monitors, small and fast temp, probes, thermoelectric heating/cooling stages for microscopes and microtomes, VIB-II Vibration Sensitivity Tester, Data Acquisition Software. Main products/instrumentation under R&D: Scientists/researchers special-purpose instruments with precision temperature measurement equipment.

Web site: www.pti-nj.com President/CEO: Charles G. Marianik Research director: Dr. Steve Sczekan R&D expertise: R&D and manufacture of fluorescence research instrumentation.

2241

PHYTERA, INC.

Add: 377 Plantation St. Worcester, MA 01605 Tel: (508) 792-6800

Technological expertise: CH/S, FL

Fax: (508) 792-1339

Principal products/instrumentation: QuantaMaster™; RatioMaster™; TimeMaster™; ImageMaster™ product lines.

Web site: www.phytera.com

Main products/instrumentation under R&D: Deltascan illuminator, timemaster stroboscopic fluorescence lifetime spectrometer. Sealed and granted patents: Deltascan Illuminator, Deltaram Illuminator, Timemaster Stroboscopic Fluorescence Lifetime Spectrometer.

2240

PHYSITEMP INSTRUMENTS, INC.

Add: 154 Huron Ave. Clifton, NJ 07013 Tel: (973) 779-5577 Fax: (973) 779-5954

President/CEO: Malcolm Morville, Ph.D. Research director: Christopher J. Pazoles, Ph.D. R&D expertise: Research of drug discovery via plant cell culture, marine microorganisms and combinatorial biology; related novel products manufacture. R&D collaboration: Amersham International, PLC.; Tsumura & Co.; Galileo Laboratories, Inc., NeuroSearch A/S, Chiron Corporation; Eli Lilly & Co.; Unilever. Technological expertise: F, E, RD, P/S, H/CF, C/TC, D-D, HTDS, SMC, AF, COC Main products/instrumentation under R&D: Anti-viral, anti-fungal agents — preclinical; plant cell culture, drug discovery route.

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Subsidiary bodies: Phytera Limited, U.K.; Phytera A/S, Denmark; Phytera Symbion A/S, Denmark.

2242

PHYTO DYNAMICS, INC.

Add: 624 South 775 East Lafayette, IN 47905 Tel: (317) 296-3497 Fax: (317) 296-3498 President: J. C. McBride Research director: A.C. McBride, Ph.D. R&D expertise: Research with crop plants and primarily corn, related novel products development/manufacture. Technological expertise: C/TC Principal products/instrumentation: Field corn inbreds and hybrids, specialty corn inbreds and hybrids, popcorn inbreds and hybrids. Main products/instrumentation under R&D: Good cropper breeding, crop plants breeding, transgenic plant, primarily corn inbreds.

2243

PHYTOGEN LIFE SCIENCES, INC.

Add: 1527 Cliveden Ave. Delta, British Columbia V3M 6P7 Canada Tel: (604) 525-5052 Fax: (604) 525-5059 President/CEO: Hai Foo Research director: Samuel Foo, Ph.D. R&D expertise: Drug discovery research; development of pharmaceutical active ingredients derived from natural products; novel pharmaceutical products manufacture.

699

Key license and trade contracts: State University of New York (Buffalo). Technological expertise: P/S, PMC Principal products/instrumentation: Paclitaxel API. Main products/instrumentation under R&D: Liposomal Paclitaxel, preclinical; Etoposidg, Natural products, pharmaceutical active ingredients derived from natural products, these products are used to treat cancer. Sealed and granted patents: Several applications pending.

2244

PHYTON, INC.

Add: 125 Langmuir Lab 95 Brown Rd. Ithaca, NY 14850 Tel: (607) 257-5058 Fax: (607) 257-5515 Web site: www.phyton.com President: K, Venkat, Ph.D. Research director: Kris Venkaf, Ph.D. R&D expertise: Bioprocess engineering research, applied development of cell and tissue culture; drug discovery research; Identifying, developing and commercializing plant-derived compounds for use in pharmaceutical/specialty chemicals industry enterprises. Major partners: Bristol-Myers Squibb Company; Indena, SpA R&D collaboration: Bristol- Myers Squibb Co.; Indena, Pfizer Key license and trade contracts: USDA. Technological expertise: F, SMC, P/S, BA, C/TC

Joint ventures: Mylan Laboratories, Sinphar Pharmaceuticals

Principal products/instrumentation: Specialty chemicals, paclitaxol, dermovita™.

R&D collaboration: B.C. Cancer Agency.

Main products/instrumentation under R&D: Taxol®, Dermovita®, other proprietary products, cell and tissue culture plant-derived compounds.

Key sales market contracts: Mylan Laboratories, Sinphar Pharmaceuticals Co. Ltd

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Subsidiary bodies: Manufacturing facility in Ahrensburg, Germany; GMP-Approved Fermentation facility.

R&D expertise: R&D manufacture of transgenic proteins. Technological expertise: T, C/TC, H/CF, P/S, RD

PHYTOWELT GMBH

Principal products/instrumentation: Transgenit proteins.

Add: Kölsumer Weg 33, D-41334 Nettetal

Main products/instrumentation under R&D: Transframe proteins, transgenic organisms.

2245

Tel: (49) 2162-77-859 Fax: (49) 2162-89-215 E-mail: [email protected]

2247

PIERCE CHEMICAL CO.

Web site: www.phytowelt.com

Add: P.O. Box 117, Rockford, IL 61105

CEO: Dr. Peter Welters

Tel: (815) 968-0747

R&D expertise: Plant biotechnology development and research, services for breeders, phytosanitary companies (regulatory affairs, field trials, project coordination, partnering for F & E).

Fax: (815) 968-7316

R&D collaboration: Heriot-Watt University Edinburgh; Max-Planck Institute for breeding research, Cologne; NMI, Reuttingers.

President: Robb Anderson

Technological expertise: T, BI, G, RD Principal products/instrumentation: Field trials with transgenic plants, plant transgenic technology, project coordination, partnering, contract research/clinical trial products. Main products/instrumentation under R&D: Diagnostics for allergen predictor, plant cloning vector.

2246

PIENGEN BIOMEDICAL COHPOBATION

E-mail: [email protected] Web site: www.piercenet.com Research director: Dennis Klenk R&D expertise: Research and manufacture of chemicals and specialty reagents Subsidiary of Perstorp. Technological expertise: PA, BA, C/TC, HTDS, PIS, P/S, SY Principal products/instrumentation: SlideA-Lyzer® dialysis cassettes; SuperSignal® substrates; SnakeSkin™ dialysis tubing. Main products/instrumentation under R&D: Specialty chemicals, specialty reagents.

2248

PIERRE GUERIN S.A.

Add: 7417 Kingston Pike Knoxville, TN 37919

Add: 179 Grand Rue, BP 12, 79210 Mauze, France

Tel: (423) 558-8200

Tel: (33) 5-4904-7800

Fax: (423) 588-8140

Fax: (33) 5-4973-3189

E-mail: [email protected]

Web site: www.pierreguerin.fr

President/CEO: E. Duglas Grindstaff

President: Jean M. Gartner

Research director: Marek M. Pienkowski, M.D., Ph.D.

Research director: Alain Chausson Subsidiary of Groupe Fives-Lille.

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R&D expertise: R&D and manufacture of stainless steel equipment and complete lines, fermenters; bioprocess engineering products. Technological expertise: F, BA, PMC, BME Principal products/instrumentation: Fermentors, agitators, reactors, tanks, pumps. Main products/instrumentation under R&D: Stainless steel equipment, bioprocess engineering products.

2249

PIONEER HI-BRED INTERNATIONAL, INC.

Add: Resource Connection, P.O. Box 1000, Johnston IA 50131-0184 Tel: (515) 270-3200 Fax: (515) 334-4415 Web site: www.pioneer.com President/CEO: Charles S. Johnson Research director: Dr. Richard L McConnell R&D expertise: R&D of biotechnology medicines (NEC), instrumentation (NEC), transgenics, bioinformation, software programs, plant genetics; related novel products manufacture. Joint ventures: Optimum Quality Grain. R&D collaboration: Collaboration with DuPont. Key license and trade contracts: MOGEN — fungal resistance technology; Ecogen Inc. — seed corn containing Ecogen’s Bt genes; Monsanto — BT gene, roundup gene; AgrEvo — glufosinate gene. Technological expertise: T, G, BTS, PS, PIS, P/PS Principal products/instrumentation: Silage, hay and high-moisture corn inoculants, hybrid corn, sorghum, sunflower, hybrids and wheat, alfalfa and canola varieties; Pioneer Information Network. Main products/instrumentation under R&D: Genetic system to reduce detasseling in corn

701

hybrid seed production; UTR tag assay for gene function discovery, antimicrobial polypeptide, plant reproduction polynucleotides. Sealed and granted patents: Compositions and methods to stack multiple nucleotide equences of interest in the genome of a plant. 6,455,315, U.S.; UTR tag assay for gene function discovery. 7,026,123, U.S.; LEC1 trancriptional activator nucleic acids and methods of use thereof, 6,825,397, U.S.; Ku80 homologue and uses thereof. 6,822,077, U.S.; Defensin polynucleotides and methods of use. 6,911,577, U.S.; Targeted manipulation of genes in plants. 6,911,575, U.S.; Compositions and methods for altering the disulfide status of proteins, 7,009,087, U.S.; RuvB orthologues and uses thereof. 6,706,949, U.S.; Transposable element-anchored, amplification method for isolation and identification of tagged genes. 6,881,539, U.S.; Methods of increasing polypeptide accumulation in plants. 6,855,871, U.S.; Isolated nematode regulated gene promoter and use thereof. 7,078,589, U.S.; Cell cycle polynucleotides, polypeptides and uses thereof. 6,933,376, U.S.; Compositions and methods for promoting expression of nucleic acids in plants. 7,041,873, U.S.; Isolated nucleic acid molecules encoding the Br2 P-glycoprotein of maize and methods of modifying growth in plants transformed therewith. 7,041,874, U.S; Methods of improving transformation efficiency of plants with auxin responsive promoter sequences. 7,052,871, U.S.; Nucleic acid encoding the FUS6 antimicrobial polypeptide of Agrotis ipsilon and its use to enhance disease resistance in a plant. 6,891,085 U.S.; Plant reproduction polynucleotides and methods of use. 6,877,988, U.S.; Maize NPR1 polynucleotides and methods of use. 6,504,084, U.S.; Genetic control of plant growth and development. 6,762,348, U.S.; Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant; many patents pending.

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PIONEER SCIENTIFIC

Add: 37 Hawthorne Rd, Shrewsbury, MA 01545 Tel: (508) 557-4724 Fax: (508) 752-6545 E-mail: customerservice@pioneerscientific. com

genome project, minerals, natural products, pesticides, reagents. Main products/instrumentation under R&D: Chromatography, chromatography media, chromatography system.

2252

PLANER PRODUCTS, LTD.

Web site: www.pioneerscientific.com President: Gary J. Deloia R&D expertise: Manufacture and supply of primary packaging components (glass vials, plastic vials, containers and components, droppers, bottles, closures, etc.) to the biotechnology, pharmaceutical and diagnostic industries. Technological expertise: AF, AB, C/TC, D-D, DD, GT, PG, P/S, CH/S, T, SMC Principal products/instrumentation: Contract manufacturing products, glass vials, rubber stoppers, aluminium seals, plastic bottles, plastic components, etc.

Add: Windmill Rd. Sunbury, Middlesex TW16 7HD U.K. Tel: (44) 1932-755-000 Fax: (44) 1932-755-001 E-mail: [email protected] Web site: www.planer.co.uk President: Geoffrey Planer Research director: Paul Lakra R&D expertise: R&D of cryopreservation, cell line freezing, cryo storage; related novel products manufacture. Technological expertise: C/TC, CH/S

2251

P.J. COBERT ASSOCIATES, INC.

Add: 2302 Weldon Parkway St. Louis, MO 63146 Tel: (314) 993-2390

Principal products/instrumentation: Controlled rate and cell line freezers. Main products/instrumentation under R&D: Cryopreservation technology, cell line freezing methods, cryo storage technology.

Fax: (314) 993-2491 E-mail: [email protected] Web site: www.cobertassoc.com President/CEO: Phillip J. Cobert

2253

PLANT BREEDING INTERNATIONAL CAMBRIDGE

Research director: Phillip J. Cobert

Add: Maris Lane, Trumpington Cambridge CB2 2LQ U.K.

R&D expertise: Chromatography production and supplies.

Tel: (44) 1223-840-411

Technological expertise: CC, P/S, CB, COC, DD, BME

President: Peter Slator

Principal products/instrumentation: Xpertek™ vials & accessories, Xpertek™ HPLC Columns, Xpertek™ Syringe Filters, Xpertek™ SPE Columns, contract research/ clinical trial products, cosmetics, human

Fax: (44) 1223-843-053 Research director: Graham Jellis Subsidiary of Unilever. R&D expertise: Plant breeding and plant growth science research; related novel products manufacture.

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Technological expertise: T, C/TC, GA

Tel: (815) 753-7841

Principal products/instrumentation: Crop varieties: wheat, barley, oilseed rape, potatoes, peas, faba beans.

Fax: (815) 753-7855

Main products/instrumentation under R&D: Molecular markers and transgenic crops, transgenic plants, plant growth regulator, corn breeding, plant breeding.

2254

PLANT GENIX, INC. (PLANT GENIX)

Add: P.O. Box 1955 Southeastern, PA 193991955 Tel: (610) 687-9452 Fax: (610) 742-3171 E-mail: [email protected]

703

E-mail: [email protected] Web site: www.bios.niu.edu President: Thomas L. Sims Research director: Thomas L. Sims R&D expertise: Plant breeding research, plant antibody and other plant drugs development. Technological expertise: Q, T, AB, BI, C/TC, CH/S, GA, RD, SY, GT Principal products/instrumentation: Agriculture, plant pharmaceuticals Main products/instrumentation under R&D: HIV targeted ribozymes Sealed and granted patents: HIV Targeted Ribozymes #5527895.

President/CEO: Robert J. Cibulsky R&D expertise: Research of plant biotechnology (traits, proteomics); related novel products manufacture.

2256

PLANTTEC BIOTECHNOLOGIC GMBH

Key license and trade contracts: University of Pennsylvania.

Add: Hermannsverder 14, Potsdam D-14473 Germany

Technological expertise: T, BI, G

Tel: (49) 331-275-670

Principal products/instrumentation: Agriculture, nutraceuticals

Fax: (49) 331-275-6777

Main products/instrumentation under R&D: Plants modified to eliminate sensitivity to ethylene, preclinical; Use of plants to manufacture various compounds (nutraceuticals), preclinical, plant biotechnology breeding.

CEO: Dr. Jorg Riesmeier

Sealed and granted patents: U.S. 5,367,065; 5,444,166; 5, 602,322; 57650,553; 5,955,652; Australian 686408; Others pending in U.S. and abroad.

2255

PLANT MOLECULAR BIOLOGY CENTER

Add: Northern Illinois University, 342 Montgomery Hall, DeKalb, IL 60115

E-mail: [email protected] Research director: Dr. Jorg Riesmeier Subsidiary of Aventis. R&D expertise: R&D and breeding of novel varieties of plant products. R&D collaboration: Aventis/universities/ scientific institutions. Key license and trade contracts: Aventis/ universities/scientific institutions. Technological expertise: T, CB Principal products/instrumentation: Agriculture, novel varieties of plants. Main products/instrumentation under R&D: DNA sequences coding for enzymes.

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Sealed and granted patents: DNA sequences coding for enzymes capable of facilitating the synthesis of linear alpha.-1,4 glucans in plants, fungi and microorganisms. 6,254,635, U.S.; method for producing alpha.-1,6-branched alpha.-1,4-glucans from sucrose. 6,699,694, U.S.

Tel: (31) 228-366-411 President/CEO: Dr. Jan Pen Research director: Dr. Jan Pen Subsidiary of Mogen Int’l nv and GistBrocades B.V. R&D expertise: R&D and production of industrial enzymes in plants.

2257

PLANT TECHNOLOGY, LTD.

Add: IDA Industrial Estate, Dublin Road, Enniscorthy Co., Wexford, Ireland Tel: (353) 54-36258 Fax: (353) 54-36255 E-mail: [email protected] Web site: www.indigo.ie President: F. Moran Research director: Dr. A. J. Sayegh R&D expertise: R&D and production of novel microplant and supply to plant industry and plant breeders/seed producers.

R&D collaboration: Plantzyme to Mogen International Inc. Key license and trade contracts: With GistBrocades B.V. for feed and food enzymes. Technological expertise: E, T, RD, ERT Main products/instrumentation under R&D: PhytaSeed® enzyme phytase produced in canola seed, used in animal feed to optimize phosphorus utilization, industrial enzymes in plants, enzymes in seeds. Sealed and granted patents: “Production of enzymes in seeds and their use”. Granted U.S.A. 5,543,576 under examination elsewhere; several patents pending.

R&D collaboration: EU projects — DNA fingerprinting of roses. 2259

PLAS-LABS, INC.

Key sales market contracts: Dibbuey Streprocarpus — worldwide except U.K. and Ireland.

Add: 401E. North St. Lansing, MI 48906

Technological expertise: RD, AF, C/TC, CH/S

Tel: (517) 372-7177

Principal products/instrumentation: Contract breeding microplant, contract research/ novel plant products, plant propagules — Calatheas, primugas, streptocarpus, potatoes, sugar beet, mardy ornamentals; plant cloning technology — consultancy and technology transfer. Main products/instrumentation under R&D: Novel microplant, plant breeders.

Fax: (517) 372-2857 E-mail: [email protected] Web site: www.plas-labs.com President: Dave Regan Research director: Michael Regan R&D expertise: R&D and manufacture of quality research equipment (anaerobic chambers, glove boxes, desiccators and custom fabrication) and shipment to all over the world. Technological expertise: BME

2258

PLANTZYME VOF

Add: Westeinde 62,Enkhuizen, Noord-Holland 1601 BK, Netherlands

Principal products/instrumentation: Intensive care system, small animal research equipment (restrainers and surgery boards), anaerobic chambers (environmental), glove

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boxes, dry boxes, desiccators and UV chambers, custom fabricated chambers. Main products/instrumentation under R&D: Quality research equipment.

2260

PLASTILITE CORP.

Add: 4930 Battlefield Dr. Omaha, NE 68152

705

Main products/instrumentation under R&D: Antibody-based chip, antibody forming cell, antibody fusion protein, antibody functional fragment.

2262

POIETICS

Tel: (402) 453-7500

Add: 904 Wind River Lane, Ste. #102 Gaithersburg, MD 20878

Fax: (402) 571-6739

Tel: (301) 926-9211

Web site: www.plastilite.com

Fax: (301) 926-9224

President: Jack Rayer

Web site: www.poietic.com.

R&D expertise: R&D and manufacture of insulating shipping containers and protective packaging for biotechnology industries.

President/CEO: Tom Bird

Technological expertise: BME, C/TC Principal products/instrumentation: Vaccines insulating shipping containers, closed containers. Main products/instrumentation under R&D: Protective.

2261

POCONO RABBIT FARM AND LABORATORY, INC.

Add: 666 Dutch Hill Road, Canadensis, PA 18325

Research director: Kim Warren Subsidiary of Bio WhittaKer Inc. R&D expertise: R&D and production of primary cells for culture and laboratory research. Technological expertise: C/TC, HTDS Principal products/instrumentation: Contract research/clinical trial products, hematopoietic progenitors; mesenchymal stem cells and stem cell assays. Main products/instrumentation under R&D: Primary cell culture, primary cell for culture, primary culture.

Tel: (570) 595-7108 Fax: (570) 595-9277 E-mail: [email protected] Web site: www.prfal.com President/CEO: Patricia Haab Research director: Scott Conklin R&D expertise: Custom antibody R&D and related novel antibody production. Technological expertise: PA, P/S, C/TC, H/CF, PIS Principal products/instrumentation: Contract research/clinical trial products, polyclonal and monoclonal antibodies to novel antigens.

2263

POLAR TECH INDUSTRIES, INC.

Add: 415 East Railroad Ave. Genoa, IL 60135 Tel: (815) 784-9000 Fax: (815) 784-9009 E-mail: [email protected] Web site: www.polar-tech.com President: Don Santeler R&D expertise: R&D and manufacture of protective packaging systems for temperature sensitive products. Technological expertise: BME

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Principal products/instrumentation: “Thermo Chill” coolers and bioshippers; “Ice Brix” gel refrigerants; “Re-freez-R-Brix” foam refrigerants; temperature monitors. Main products/instrumentation under R&D: Protective packaging systems for temperature sensitive products.

2264

POLYCELL, INC.

Add: 321 Fisher Bldg. 3011 W.Grand Blvd. Detroit, MI 48202 Tel: (313) 871-4151 Fax: (313) 873-4935 Web site: www.cell.com

Principal products/instrumentation: Contract manufacturing products, synthesis of blocked free and tagged multig medium sized peptides u11. HPLC separation of natural products including peptides and proteins, fermentation products. Polymeric reagents for synthesis and tagging with chromophors of the universal type standards. Main products/instrumentation under R&D: Apparatus for multipolymer synthesis system, universal standard reagents. Sealed and granted patents: Method and apparatus for multipolymer synthesis system, U.S. patents 455,922 and 4698208 also ECM, Japan, Canada and Israel; Universal standard reagents pending patents U.S.A., Japan, ECM and Israel; other patents pending.

President: Monis Schuster Subsidiary of Quest BioTedmology, Inc. R&D expertise: R&D of monoclonal antibody technology, related novel products manufacture. Technological expertise: AB, C/TC Main products/instrumentation under R&D: Novel monoclonal antibodies; monoclonal antibody to CD4, 5a8; monoclonal antibody against hepatitis B virus.

2266

POLYCOMP, INC.

Add: 1 West Pine Court St. Louis, MO 63108 Tel: (314) 516-5318 Fax: (314) 516-5342 E-mail: [email protected] Web site: www.polycomp-inc.com President/CEO: William J, Welsh, Ph.D.

2265

POLY-CHEM PCJ, LTD.

Add: 9 Zrubavel St. Ness-Ziona 70450 Israel Tel: (972) 8-940-4183 Fax: (972) 8-940-7443 E-mail: copatch2@weizmann President: Prof. A. Patchornik R&D expertise: R&D and manufacture of synthetic peptides, analytical equipment, including HPLC, novel universal standard reagents, polymeric reagents for synthesis and tagging research. Technological expertise: CC, COC, PIS, P/X, P/S, SMC, SY, PS/AP, P, PI, PPAT

Research director: William J. Welsh, Ph.D. R&D expertise: Research of computer-aided chemistry and drug design, pattern recognition tools, molecular and polymer modeling, data analysis, etc. Related products development/ manufacture. Technological expertise: AF, AB, BI, CH/S, DD, D-D, HTDS, SY Principal products/instrumentation: Contract R&D products, molecular and polymer modeling, pattern recognition tools. Main products/instrumentation under R&D: Computer-aided chemistry and drug design, pattern recognition tools, data analysis systems for drug research.

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2267

POLYLABO

Add: BP 36, 10 Rue de Ladurance 67023 Strasbourg, Cedex 67023 France Tel: (33) 388-658-046 Fax: (33) 388-397-441 Web site: www.polylabo.com President: Gerard Pochat

707

PolySULFOETHYL Aspartamide™, PolyHYDROXYETHYL.Aspartamide™, PolvGLYCOPLEX™. Main products/instrumentation under R&D: HPLC columns for biotechnology medicines research. Sealed and granted patents: 4,517,241 — 1985; Chromatographic support material, other patents pending.

Research director: Jolelyne Cachat Subsidiary of Merck S.A. R&D expertise: R&D of novel drugs and biomedical equipment.

2269

POLYMASC PHARMACEUTICALS PLC.

Technological expertise: E, PA, Q, GA, HTDS, P/S, RD, BME

Add: Fleet Rd. London NW3 2EZ U.K.

Principal products/instrumentation: Biologicals, cosmetics, human genome project, instrumentation, pharmaceuticals, plastics; contract R&D products.

Fax: (44) 207-284-3107

Main products/instrumentation under R&D: Novel drug screening, drug resistance strain, lab biomedical equipment for drug research.

President: Dr. Gillian Francis

2268

POLYLC, INC.

Add: 9151 Rumsey Rd., Suite 180 Columbia, MD 21045 Tel: (410) 992-5400 Fax: (410) 730-8340 E-mail: [email protected] Web site: www.polylc.com President/CEO: Andrew J. Alpert R&D expertise: R&D and manufacturing of HPLC columns for protein, peptide and other life science research applications.

Tel: (44) 207-284-3100 E-mail: [email protected] Web site: www.polymasc.com R&D expertise: Research, development, manufacture and license of proprietary formulations technologies, therapeutics and biodiagnostic agents. Key license and trade contracts: TKT Cangene, Bayer, Onyx. Technological expertise: P/S, DD, GT, PPAT, PS, P/PS, PI Main products/instrumentation under R&D: Biologics delivery of proteins/peptides and viral vectors, preclinical; fractionating polyethylene glyol-proteins, adduct of PEG and GM-CSF. Sealed and granted patents: Process for fractionatinig polyethylene glycol-protein adducts and an adduct of PEG and granulocytmacrophage colony-stimulating factor. 6,384,195, U.S. other patents pending.

Technological expertise: P/S, SY, PPAT, PS, P/PS, PIS Principal products/instrumentation: PolyCATA™, PolyMETHYL Aspartamide™, PoIyETHYL Aspartamide™, and PolyPROPYL. Aspartamide™, PolyWAX LP™,

2270

POLYMER LABORATORIES, INC.

Add: Amherst Fields Research Park 160 Old Farm Rd. Amherst, MA 01002

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Tel: (413) 253-9554

E-mail: [email protected]

Fax: (413) 253-2476

Web site: www.polymicro.com

E-mail: [email protected]

President: Gary Nelson, General Manager

Web site: www.polymerlabs.com

Research director: Gary Nelson, General Manager

President: Frank P. Warner, Ph.D. Subsidiary of Polymer Laboratories Ltd. R&D expertise: R&D and production of polymeric particles for biochromatography, carbohydrates analysis HPLC, GPC, resins for combinatorial chemistry, diagnostic latex particles, peptide and peptide instrumentation. Technological expertise: SY, SMC, COC, HTDS, PIS, P/S Principal products/instrumentation: PL gel; PLRP-S; PL-SAX; PL-SCX; PL-GFC, PlPEGA; PL-DMA; PL-CMS; PL-Latex; PLEMD 960; PL-GPC210; PL aquagel, solid phase synthesis supports, PL-CMS resins (chloromethylstyrene), PL-WANG resins (palkoxybenzyl alcohol resin), PL-AMS Resin (aminomethylstyrene), PL-DMA resin (acryloysarcosine/dimethylacrylamide) and PLPEGA resins (polyethyleneglycol/acrylamide), peptide purification and analysis, PLRP-Spolymeric reversed phase columns and media. Main products/instrumentation under R&D: PL-AFC affinity chromatography columns and media, polymeric particles for biochromatography, carbohydrates analysis HPLC, etc. Subsidiary bodies: Polymer laboratories Ltd, Essex Road, Church Stretton, Shropshire, SY6 6AX, U.K.; Tel: (44) 16-9472-3581; Fax: (44) 16-9472-2171.

2271

POLYMICRO TECHNOLOGIES, LLC.

Add: 18019 N. 25th Ave. Phoenix, AZ 850231200 Tel: (602) 375-4100 Fax: (602) 375-4110

R&D expertise: R&D and manufacture of fused silica capillary, tubing step index, multimode optical fiber, hollow silica, waveguides, bundles, cables, assemblies, multilumen tubing, etc. Technological expertise: BME Principal products/instrumentation: GC and CE capillary tubing, multimode step index fiber, assemblies/arrays. Main products/instrumentation under R&D: Fused silica capillary, multimode optical fiber, hollow silica, waveguides.

2272

POLYPEPTIDE LABORATORIES A/S

Add: Herredsvejen 2, 3400 Hillerod, Denmark Tel: (45) 4820-7000 Fax: (45) 4820-7005 E-mail: ppl@polypeptide. dk Web site: www. polypeptide.com President: Erik Lorentsen Research director: Anders Anderson, Ph. D Subsidiary of PolyPeptide Laboratories BV. R&D expertise: R&D, manufacture and marketing of numerous GMP-grade generic peptides, also contract R&D and manufacture of peptides. Technological expertise: CS, P, PI, PIS, PS, P/PS, PPAT. Principal products/instrumentation: Numerous GMP-grade generic peptides including: Somatostatin, Leuprolide, LH-RH, Oxytocin, Salmon Calcitonin, Vasopressin, Goserelin, ACTH and CRH.

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Main products/instrumentation under R&D: Novel GMP-grade generic peptides, peptide synthesizer, peptide sequencer. Subsidiary bodies: PolyPeptide Laboratories, A/B — Malmo, Sweden; PolyPeptide Laboratories, GmbH — Wolfenbuttel, Germany; PolyPeptide Laboratories, S. R.O. — Prague, Czech Republic, PolyPeptides, Inc. — Torrance, CA-U.S.A.

2274

709

POLYPEPTIDE LABORATORIES, INC.

Add: 365 Maple Ave. Torrance, CA 90503 Tel: (310) 782-3569 Fax: (310) 782-3645 E-mail: [email protected] Web site: www.polypeptide.com President: Dr. Jane Salik

2273

POLYPEPTIDE LABORATORIES GMBH

Add: Halchtersche Strasse 49 Wolfenbuttel D38304 Germany Tel: (49) 5331-956-10 Fax: (49) 5331-956-113 E-mail: [email protected] Web site: www.polypeptide.com President: Dr. Wolfgang Heinzel Subsidiary of Polypeptide Laboratories B.V. R&D expertise: R&D and production of peptides and peptide instrumentation. Technological expertise: PIS, P/S, CS, PS, PI, PS/AP Principal products/instrumentation: Diverse peptides, hundreds of peptides for basic research and therapeutic applications. Generic peptides produced under GMP include: Salmon calcitonin, Somatostatin, Oxytocin, Vasopressin, Leuprolide, LH-RH, Goserelin, ACTH and CRH. Main products/instrumentation under R&D: New products for extensive peptide catalog, custom peptides for preclinical evaluation, peptide library, peptide sequencer, peptide T, peptide synthesizer, polypeptidase, polypeptide drugs. Subsidiary bodies: Polypeptide Laboratories B.V.; Polypeptide Laboratories A/S; Polypeptide Laboratories AB; Polypeptide Laboratories Inc; Polypeptide Laboratories GmbH; Polypeptide Laboratories.

Research director: Dr. Nagana Goud Subsidiary of Polypeptide Laboratories BV. R&D expertise: Peptides and peptide instrumentation R&D, large-scale manufacturing of generic and custom peptides for therapeutic applications. Technological expertise: CS, PI, PIS, P/S, PPAT Principal products/instrumentation: GMP contract manufacturing products, numerous generic peptides products, including: Somatostatin, Leuprolide, LH-RH Oxytocin, Salmon Calcitonin, Vasopressin, Goserelin, ACTH and CRH. Gonadorelin, Octreotide. Main products/instrumentation under R&D: Numerous proprietary peptides, new generic and research peptides, peptide library, peptide sequencer, peptide T, peptide synthesizer, polypeptidase, polypeptide antibiotics. Subsidiary bodies: PolyPeptide Laboratories A/S, Herredsvejen 2, DK-3400 Hillerod, Denmark, Tel: (45) 4820-7000, Fax: (45) 4820 7005, E-mail: [email protected]; Malmo, Sweden; PolyPeptide Laboratories, GmbH — Wolfenbuttel, Germany; PolyPeptide Laboratories, SpoL — Prague, Czech Republic.

2275

POLYSCIENCES, INC.

Add: 400 Valley Rd. Warrington, PA 18976 Tel: (215) 343-6484 Fax: (215) 343-0214

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E-mail: [email protected]

Tel: (262) 268-9300

Web site: www.polysciences.com

Fax: (262) 268-9400

President: Michael Ott

E-mail: [email protected]

Research director: Dr. David Jordan

Web site: www.popeinc.com

R&D expertise: R&D and production of specialty chemicals for life sciences.

President: Ann Martin

Technological expertise: PA, SMC, P/S, SY

R&D expertise: R&D and manufacture of evaporators/concentrators/stills for heat sensitive materials, also tanks, vessels, reactors, fermenters, and vessel systems for pharmaceuticals, biomaterials, ultrapure substances, contract manufacturing products, evaporation and distillation.

Principal products/instrumentation: Polybead™ polystyrene latex micropartides; Centricell™ centrifugal ultrafiltration devices for large volumes; embedding kits for light and electron microscopy. Main products/instrumentation under R&D: Diagnostic test kits, specialty chemicals for life science research.

2276

POLY SOFTWARE INTERNATIONAL, INC.

Add: P. O. Box 60, Pearl River, NY 10965 Tel: (845) 735-9301 Fax: (845) 735-9303 E-mail: [email protected] Web site: www.polysoftware.com President: John Wang Research director: John Wang R&D expertise: R&D and manufacture of scientific software.

Research director: Mark Talkington

Technological expertise: F, TE, CH/S, PMC, P/S, AB, BA, PIS, SY Principal products/instrumentation: Wipedfilm stills for evaporation, concentration, molecular distillation of heat-sensitive materials. Stainless steel pressure vessels and integrated vessel systems including fermenters, holding/ transfer/shipping tanks, reactors, dispensers, fractional distillation equipment, toll evaporation and distillation services; separation system, 2007 Main products/instrumentation under R&D: Nutsche Filter Systems, concentrators, vessel systems for pharmaceuticals. Subsidiary bodies: Toll Processing Facility.

2278

POPPER & SONS

Joint ventures: PSI-Plot, Pro-Stat Technological expertise: CH/S Principal products/instrumentation: PSIplot, ProStat. Main products/instrumentation under R&D: Scientific research software, pharmaceutical research software.

Add: 300 Denton Ave. New Hyde Park, NY 11040-0134 Tel: (516) 248-0300 Fax: (516) 747-1188 E-mail: [email protected] Web site: www.popperandsons.com President: Joseph A Popper

2277

POPE SCIENTIFIC, INC.

Add: 351 N. Dekora Woods Blvd., P.O. Box 80018, Saukville, WI 53080

Research director: Zev Asch R&D expertise: Development and manufacture of laboratory biomedical equipment and labwares.

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Technological expertise: BME, PMC

Technological expertise: C/TC, ET, E

Principal products/instrumentation: High quality precision needles, probes and cannulae for diagnostics, in vitro, analytical instruments of scientific research. Adapters and Luer connectors in brass and 316 stainless steel. Glass syringes in l/4ml to 250ml.

Principal products/instrumentation: Dysport™, Dopacard®, vaccines for anthrax and botulism, HyateC® for hemophilia, Asparaginase for acute lymphocytic leukemia in children — on U.K. market, nafamostat protease inhibitor.

Main products/instrumentation under R&D: Laboratory apparatus, laboratory-size reactor.

2279

Main products/instrumentation under R&D: Whooping cough vaccine, clinicals in U.K.; Botulinum toxin A for muscle system, registered in U.K.

POROUS MATERIALS, INC. 2281

PORVAIR SCIENCES, LTD.

Add: 20 Dutch Mill Rd., Ithaca, NY 14850 Fax: (607) 257-5639

Add: Dorset House, Regent Park, Kingston Road, Leatherhead KT22 7PL, U.K.

E-mail: [email protected]

Tel: (44) 1372-824-290

Web site: www.pmiapp.com

Fax: (44) 1372-824-271

President: Krishna Gupta

Web site: www.porvair-sciences.com

R&D expertise: R&D and manufacture of instrumentation for porosity analysis.

President: T. Castleman

Technological expertise: PMG, BME

Subsidiary of Porvair PLC.

Principal products/instrumentation: Porosimeters, surface area analyzers, permeability testers, density and porosity analyzers.

R&D expertise: Manufacturer and marketing of microplates for niche applications.

Tel: (607) 257-5544

Main products/instrumentation under R&D: Instrument for analysis, porosity analytical devices.

2280

PORTON INTERNATIONAL, PLC.

Add: 100 Piccadilly London W1V 9FN U.K. Tel: (44) 20-6290-200 President: Zsolt Harsanyi Subsidiary of Beaufour-Ipsen. R&D expertise: R&D and manufacture of new pharmaceutical products, and commercializing products developed at the CAMR and St George’s Hospital Medical School. Key license and trade contracts: Torli & Co. — nafamostat protease inhibitor.

Research director: R. Ireland

Technological expertise: P/S, C/TC, COC, HTDS Principal products/instrumentation: Microlute™ — solid phase extraction in 96 well format, 384 well plates, deep well plate family, patented piercable sealing cap, Optiplate 1 and 2™, Filtaplates™. Main products/instrumentation under R&D: Microplates for niche applications. Sealed and granted patents: Microlute™, sealing cap, plus others (confidential); other patents pending.

2282

POST HOTEL

Add: 02 Le Loi St.: 08 Le Chan St. Nha Trang, Knanh Hoa 5700 Vietnam

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Tel: (84) 9-146-0292

2284

Fax: (84) 9-882-4205

POWDERJECT PHARMACEUTICALS PLC.

President: Khanh Hoa P&T R&D expertise: Manufacture and supply of laboratory research instrumentation and reagents. Technological expertise: Q, TE, CC, T, E, DD, COC, CB, BS, SMC, H/CF, R, C/TC, PG, AB, SY, RD, AF, PMC, BI, BA, G, GA, GT, HTDS, PIS, P/S, CH/S Principal products/instrumentation: Nutraceuticals, biomaterials, bioremediation, chemicals, reagents, toxic waste processing, plastics, diagnostics, biosensors, clinical tests, pesticides, organ transplants/culture, biopharmaceuticals, process validation, human genome project, contract manufacturing products, in vitro toxicology testing technique, contract research/clinical trial products. Main products/instrumentation under R&D: Laboratory research instruments, novel reagents.

Add: Florey House, Robert Robinson Ave. The Oxford Science Park Oxford OX4 4GA U.K. Tel: (44) 1865-332-600 Fax: (44) 1865-332-601 Web site: www. powderject.com CEO: Dr. Paul Drayson Research director: Dr. Terry Burkoth Subsidiary of PPD, Inc. R&D expertise: R&D and production of powder injection of drugs, biopharmaceuticals, conventional and DNA vaccines and diagnostics using the unique Powderject delivery technology. Joint ventures: Glaxo Wellcome (US$300 million DNA vaccine alliance); Ares-Serono (US$100 million multi protein agreement); Pfizer; AstraZeneca; Avento Pasteur, Medeva; Ceutech; Baxter. Technological expertise: RD, DD

2283

POUCONSULT SCIENTIFICA

ADD: via Campo Fornia 130 Roma 00178 Italy Tel: (39) 672-900-603/4/5 Fax: (39) 672-900-601 President: Anaderio Francesco R&D expertise: Manufacture and marketing of clinical diagnostic products.

Main products/instrumentation under R&D: Diagnostics, pharmaceuticals, vaccines, Powderject Lidocaine, Phase III; Powderject Alprostadil, Phase II/III; Powderject Hepatitis B DNA vaccine, Phase II; Powderject system for power injection. Sealed and granted patents: Broad portfolio of over 60 patent families covering methods, devices and formulations for use in the Powderject system for powder injection.

Technological expertise: BME, C/TC Principal products/instrumentation: Clinical tests, diagnostics, instrumentation, veterinary products, contract manufacturing products. Main products/instrumentation under R&D: Clinical diagnostic aids, clinical diagnostic agents, diagnostic enzymes, diagnostic kits, diagnostic reagents.

2285

POWDERJECT VACCINES, INC.

Add: 585 Science Drive Madison, WI Tel: (608) 231-3150 Web site: www.powderject. com R&D expertise: Research of biotechnology medicines with a focus on DNA vaccines for treatment of tumor, hepatitis, etc.

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Technological expertise: RD, PPAT Principal products/instrumentation: Anticancer drug, antibody fusion protein, diagnostic reagents. Main products/instrumentation under R&D: gp100 DNA vaccine for treatment of tumors, Phase II, 2005; gp100 DNA plasmid vaccine vector in gold particles, for treatment of melanoma, Phase II, 2004; Hepatitis B DNA vaccine for treatment of hepatitis B, Phase II, 2005.

2286

PPD DEVELOPMENT

Add: Lockton House Clarendon Cambridge CB2 2BH U.K.

Rd.

Tel: (44) 1223-272-272

713

Key sales market contracts: Research Trial Management Systems (KTMS); Proprietary informatics software: Table-Trans®, CrossGraphs®, CG++®; Preclinical software: First Pass™ program and SAR System™. Technological expertise: BI, CH/S, PG, DD, BTS Principal products/instrumentation: Clinical tests, contract research/clinical trial products, process validation. Main products/instrumentation under R&D: Innovative technologies for drug discovery, new targets for agents against HIV new targets for selectively eradication cancer cells, functional system. Subsidiary bodies: 46 office in 19 countries: America 24; Europe 17; Asia 2; Pacific Rim 1; Africa 1; Middle East 1.

Fax: (44) 1223 352-298 Web site: www.ppdi.com CEO: Fred N. Eshelman, Ph.D. Subsidiary of PPD, Inc. R&D expertise: Research of innovative technologies, therapeutic expertise, and comprehensive resources for drug discovery, clinical development, and post-market support, provision of comprehensive analytical lab and Phase I–IV clinical development services to pharmaceutical and biotechnology companies. Joint ventures: Forms the largest pharmacogenomics products and services organization, PPGx, from joint venture with Axys Pharmaceuticals. R&D collaboration: Alliance with Texas Heart Institute to collaborate on cardiovascular trials; alliance with Eli Lilly & Co., to create PPd GenuPro, Inc.; Genomics alliances with Agouron to identify new targets for agents against HIV and for selectively eradicating cancer cells; alliance with ADoctorln YourHouse.com to provide web-based education and service as an information resource on phamacogenomics.

2287

PPD DISCOVERY

Add: 3500 Paramount Pkwy. Morrisville, NC 27560 Tel: (919) 462-5600 Fax: (919) 462-5610 E-mail: [email protected] Web site: www.ppdi.com President: Dr. Bradley B. Brown Research director: Gail McIntyre Subsidiary of PPD Development. R&D expertise: Development and manufacture service of combinatorial and medicinal chemical to the pharmaceutical, biotechnology, agriculture and animal health industries. Key license and trade contracts: Duke University. Technological expertise: SMC, BI, COC, D-D Principal products/instrumentation: Agriculture, specialty chemicals, contract research/ clinical trial product, pharmaceuticals, veterinary products.

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Main products/instrumentation under R&D: Combinatorial medicinal chemical to biotechnology medicines. Sealed and granted patents: Several patents are pending

2288

PPD, INC.

Add: 929 N. Front St., Wilmington, NC 28401-3331 Tel: (910) 251-0081 Fax: (910) 762-5820 Web site: www.ppdi.com CEO: Fred Eshelman, Pharm. D. R&D expertise: R&D of innovative technologies, therapeutic expertise, and comprehensive resources for drug discovery, clinical drug development, and post-market support, contract and consulting discovery research and development services for pharmaceutical and biotechnology companies. Joint ventures: Forms largest phamnacogenomics products and services organizations, PPGx, from joint venture with Axys Pharmaceuticals. R&D collaboration: Alliance with Texas Heart Institute to collaborate on cardiovascular trials. Genomics alliance with Rhone-Poulenc Rorer (Aventis) for development of new therapeutic agents. Alliance with Eli Lilly & Co., to create PPD GenuPro, Inc. Genomic alliances with Agouron to indentify new targets for agents against HIV and for selectively eradicating cancer cells. Alliance with ADoctorInYourHouse.com to provide web-based education and service as an information resource on pharmacogenomics. Key sales market contracts: (Intellectual Property and Products) Research Trial Management Systems-(RTMS™); Proprietary informatics software: Table-Trans®, CrossGraphs®, CG++®. Preclinical software: First Pass™ program; SAR System™.

Technological expertise: BI, G, SMC, COC, CH/S, PG Principal products/instrumentation: Clinical tests, contract research/clinical trials products, biopharmaceuticals, process validation. Main products/instrumentation under R&D: Innovative technologies for drug discovery, new targets for agents against HIV, new target for selectively eradicating cancer cells, functional genomics system. Subsidiary bodies: 44 Offices in 19 countries worldwide: America 22, Europe 17, Asia 2, Pacific Rim l, Africa 1, Middle East 1. Sealed and granted patents: Functional Genomics System (GSX System); other patents pending.

2289

PPL THERAPEUTICS

Add: Roslin Edinburgh, Scotland EH25 9PP U.K. Tel: (44) 131-440-4777 Fax: (44) 131-440-4888 President/CEO: Ron James, Ph.D. Research director: Alan Golman, Ph.D. R&D expertise: Development and manufacture of proteins in the milk of genetically modified livestock for therapeutic and nutraceutical use. R&D collaboration: Wyeth-Ayerst (American Home Products); Astra Hassle AB; FibroGen Inc., ZymeGenetics. Technological expertise: T, P/S, RD, PIS, P, PI, PS Main products/instrumentation under R&D: Biologicals, beta lactoglobulin, alpha lactalbumin, contract manufacturing products, organ transplants/culture products, Alpha-I-Antitrypsin (Phase III), Fibrinogen (preclinical), Xenograft (preclinical), Bile Salt-Stimulated Lipase (BSSL) (preclinical). Subsidiary bodies: Blacksburg, VA — U.S.A.; New Zealand.

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Sealed and granted patents: Beta lactoglobulin, nuclear transfer, alpha lactalbumin, fibrinogen, protein C, amidated peptides.

2290

PPL THERAPEUTICS, INC.

715

Main products/instrumentation under R&D: Enzyme immunoassay kit for algal toxins, bioassay for diarrhetic, shellfish poisoning toxins licensed technology ready for commercialization, bioremediation, biologicals, contract research/clinical trial products, diagnostic enzymes, diagnostic kits.

Add: 1700 Kraft Dr. Suite 2400 Blacksburg, VA 24060 Tel: (540) 961-5559 Fax: (540) 961-7958 President/CEO: Ron James, Ph.D. Research director: David Ayares, Ph.D. Subsidiary of PPL Therapeutics PLC. R&D expertise: Production of recombinant proteins in the milk of transgenic livestock (research, development, manufacture).

2292

PRECISION DETECTORS, INC.

Add: 10 Forge Park Franklin, MA 02038 Tel: (508) 520-8765 Fax: (508) 520-8772 E-mail: [email protected] Web site: www.precisiondetectors.com President/CEO: Peter Wallace

Technological expertise: T, RD, P/S, BA, PIS

Research director: Trevor Havard

Principal products/instrumentation: Examples of peptides produced include calcitonin and GLP-1, fusion peptide, peptide manufacturing “instrumentation”.

R&D expertise: Design, development and manufacture of laser light scattering instruments for biopharmaceutical molecular analysis.

Main products/instrumentation under R&D: Protein C, new fusion protein, recombinant proteins in the milk of transgenic livestock. Subsidiary bodies: Edinburgh, Scotland — Headquarters.

2291

PRAIRIE BIOLOGICAL RESEARCH, LTD.

Add: 4290-91A St., Block C Edmonton, Alberta T6E 5V2 Canada Tel: (403) 450-3957

Key sales market contracts: Fisher Scientific (Life Science Division). Technological expertise: PA, BA, CB, GT, PMC, P/S, RD, DD Principal products/instrumentation: Flow through Mw and Rh detection for SEC, PD2000/DLS; Batch DLS particle sizer, PDDLS/Batch. Main products/instrumentation under R&D: Laser light scatter for biopharmaceutical molecular analysis, laser probes. Sealed and granted patents: #5,305,073, #5,701,176.

Fax: (403) 450-3960 President/CEO: Ram Mehta, Ph.D.

2293

PRECISION INSTRUMENTS

Research director: Ram Mehta, Ph.D. R&D expertise: Contract R&D and manufacture of diagnostics in the fields of microbiology and toxicology.

Add: 388/1 Old Tehsil, behind Id-Gah Roorkee, UP 247667 India

Technological expertise: T, PA, F, C/TC

Fax: (91) 133-274-277

Tel: (91) 133-272-277

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President: M. A. Ansari

Tel: (978) 521-7095

R&D expertise: Development and production of precision instruments.

Fax: (978) 374-5568

Joint ventures: Survey Instruments Services Pte. Ltd., Singapore

President: Peter Shahinian

R&D collaboration: Feno Marks, Thilay, France. Key sales market contracts: Testwell Scientific Instruments, Bombay Technological expertise: T, G, GT, H/CF, BI, GA Principal products/instrumentation: Survey instruments, test well scientific instruments. Main products/instrumentation under R&D: Precision delivery system, precision instruments.

2294

PRECISION SCIENTIFIC, INC.

Web site: www.balances.com Research director: Robert DiBurro R&D expertise: Development, manufacture and supply of precision weighing balances. Principal products/instrumentation: Balances, scales, weighing accessories and weighing dishes both for retail and wholesale. Main products/instrumentation under R&D: Precision weighing balances, precision weighing method.

2296

PRECURSOR CHEMICALS, INC.

Add: 170 Marcel Dr. Winchester, VA 22602-4843

Add: 777 Schwab Road, Suite L, Hatfield, PA 19440

Tel: (540) 869-9892

Tel: (215) 855-5336

Fax: (540) 869-0130

Fax: (215) 855-5338

President: Lyle E. Cady

E-mail: [email protected]

Research director: Clifford C. Johnson Subsidiary of Varlen Corp. R&D expertise: Cell and tissue culture research, manufacture of laboratory equipment for industrial, educational, government and clinical laboratories. Technological expertise: C/TC, RD, P/S

Web site: www.precursorchem.com President: Dr. Bo Zhou Research director: Dr. Bo Zhou R&D expertise: R&D and manufacture of special intermediates for pharmaceutical and agrochemical industries.

Principal products/instrumentation: Napco® CO2 Incubators; Precision water baths; Thelco® laboratory ovens; Precision incubators; Napco® vacuum ovens; Napco® autoclaves; Precision® vacuum pumps; Autoclaves.

Technological expertise: SMC, CB, SY

Main products/instrumentation under R&D: Cell and tissue culture.

Main products/instrumentation under R&D: 5-Amino levulinic acid, special intermediates for pharmaceutical industry.

2295

PRECISION WEIGHING BALANCES

Add: l0 Peabody St. Bradford, MA 01835

Principal products/instrumentation: Pyrrole derivatives; contract manufacturing products, contract research/clinical trial products, nutraceuticals, pharmaceuticals.

2297

PREISER SCIENTIFIC, INC.

Add: 94 Oliver Street, St. Albans, WV 25177

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Tel: (304) 727-2902 Fax: (304) 727-2932 E-mail: [email protected] Web site: www.preiser.com President: A. E. Preiser Research director: J. Gatens R&D expertise: Development and production of general laboratory equipment and supplies. Technological expertise: BME Principal products/instrumentation: Microscopes, spectrophotometers, pH meters, analytical balances, ovens, furnaces, water stills, microgrippers. Main products/instrumentation under R&D: Microgrippers, general laboratory equipment, labwares, computer-aided laboratory management system and other biomedical laboratory equipment. Subsidiary bodies: Microgrippers. Sealed and granted patents: Microgripper products, other patents pending.

717

Technological expertise: SMC, RD, P/PS, PPAT Principal products/instrumentation: Biologicals, biomaterials, contract manufacturing products, contract research/clinical trial products, diagnostics, natural products, nutraceuticals, organ transplants/culture, vaccines. Main products/instrumentation under R&D: Small molecule drugs, recombinant proteins. gene therapy products, gene transduction technique, antibodies and vaccines to implantable devices.

2299

PRIME SYNTHESIS, INC.

Add: 2 New Road, Suite 126, Aston, PA 19014 Tel: (610) 558-5920 Fax: (610) 558-5923 Web site: www.primesynthesis.com President/CEO: David Rothstein Research director: Marc Rothstein R&D expertise: Peptides and peptide instrumentation for DNA synthesis.

2298

PRIMEDICA CORPORATION

Add: 57 Union St Worcester, MA 01608 Tel: (508) 890-0100 Fax: (508) 753-1834 E-mail: [email protected] President: Peter H. Glick Subsidiary of Genzyme Transgenics Corporation. R&D expertise: Biotechnology product research/development services, from discovery support and toxicologic assessments to manufacturing and release testing of marketed products; numerous studies on a wide range of biotechnology products, from recombinant proteins, monoclonal antibodies and vaccines to implantable devices, small molecules and gene therapy products.

Joint ventures: Biolytic Laboratory Performance — Nationwide coverage of service for all types of DNA synthesizers. Key sales market contracts: BioResin, Inc. — Exclusive marketing and sales agreement for DNA synthesis instrumentation; Chemassist, Inc. — Exclusive marketing and sales agreement for unique DNA synthesis and peptide products. Technological expertise: P, Y, CH/S, AT, COC, CS Principal products/instrumentation: Amino acids, DNA synthesis consumables, columns, reagents, phosphoramidites and many specialty reagents, PPG™ Prime Performance Glass (controlled pore glass), large scale production and derivatization of nucleosides into PPG. ITEM™, a 24 column expansion module for DNA synthesizers. MOLECULAR TRAPS™,

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molecular sieve packets for maintaining low water content in solvents and removal of amine contaminants from DMF and NMP. DNA synthesizer and peptide synthesizer instrument, upgrades and reconditioned instrument, peptide synthesizers, peptide sequencer. Main products/instrumentation under R&D: Improved PPG™ (controlled pore glass) and other novel DNA and peptide synthesis products.

R&D expertise: R&D of clinical chemistry, analytical chemistry and capillary electrophoresis instruments; related novel products manufacture. Principal products/instrumentation: Capillary electrophoresis instrument UV-VIS detector; data acquisition/analysis software.

2302 2300

PRINCETON BIOMOLECULES CORPORATION

PRIMM LABS, INC.

Add: 8 Rutledge St., Boston MA 02132

Add: 2260 Cabot Blvd. West, Ste 4, Langhome, PA 19047

Tel: (617) 774-6652

Tel: (215) 891-0415

Fax: (617) 249-0939

Fax: (215) 891-0419

E-mail: [email protected]

E-mail: [email protected]

Web site: www.primmlabs.com

Web site: www.pbcpeptide.com

President/CEO: Richard Stelluto

President: Michael G. Shiue

R&D expertise: Contract R&D and manufacture of biopharmaceuticals; automated in situ hybridization; contract biotechnology medicine research services.

Research director: Eric Yang

Technological expertise: PA, Q, AB, GA, PIS, RD Principal products/instrumentation: Contract manufacturing products, in situ Pro, automated in situ HyB. Main products/instrumentation under R&D: Analytical biochemistry reagents.

2301

PRINCE TECHNOLOGIES

R&D expertise: R&D of custom peptide synthesis and peptide instrumentation. Technological expertise: PA, COC, P/S, PIS, SY Principal products/instrumentation: Custom peptides, biotin-peptides, phosphorpeptides, fluorescent-peptides, osteocalcin. Main products/instrumentation under R&D: Dye-peptides, peptide sequencer, peptide synthesizer, peptide T, peptidoglycan polymer.

2303

PRINCETON POLYMER LABORATORIES

Add: BO Box 2194, 7801 CD Emmen, The Netherlands

Add: 521 Lehigh Ave., Union, NJ 07083

Tel: (31) 591-629-184

Tel: (908) 687-7033

Fax: (31) 591-628-385

Fax: (908) 687-1147

Web site: www.princetechnologies.eu

E-mail: [email protected]

President: M. J. Stephenson

Web site: princetonpolymer.com

Research director: H. H. Laver

President: Peter Wachtel

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Research director: Allan Blair, Ph.D. R&D expertise: R&D and manufacture of biopolymers; contract research other polymers. R&D collaboration: Army CRADA on biopolymers. Technological expertise: F, BA, SY, FL, POS Principal products/instrumentation: Chitomer, Galactomed, Algaeton. Main products/instrumentation under R&D: Biopolymers, polymer drug.

2304

PRINCETON SEPARATIONS, INC.

Add: 100 Commerce Ave., Freehold, NJ 07710 Tel: (732) 431-3338 Fax: (732) 431-3768 E-mail: [email protected] Web site: www.prinsep.com President: Paul Nix, Ph.D. Research director: Stuart Levison, Ph.D. R&D expertise: Fundamental applied research of molecular biology and clinical electrophoresis, related novel products manufacture. Technological expertise: P/S, P/P, P/S, SMC Principal products/instrumentation: CentriSep spin columns for the purification of large molecules (particularly DNA) from small molecules, used in sequencing, PCR, etc. Panagel® high resolution agarose electrophoresis for clinical diagnostics-equipment and gels; CentriSpin™ spin columns broaden the purification line by providing a variety of exclusion limits, The new PSI.Clone™ family of molecular biology kits includes an innovative plasmid Prep Kit. Main products/instrumentation under R&D: Clinical electrophoresis apparatus, clinical electrophoresis pattern.

2305

PRIOR SCIENTIFIC, INC.

Add: 80 Reservoir Park Drive Rockland, MA 02370

719

Tel: (781) 878-8442 Fax: (781) 878-8736 E-mail: [email protected] Web site: www.prior.com President/CEO: R. Patrick Drexel Subsidiary of Prior Scientific Ind. Ltd. R&D expertise: Development and manufacture of microscope and fittings. Principal products/instrumentation: MicroScope Stesis, ProScan; MicroScope Stesis, OptiScan; MicroScope Stesis, ErsoScan; Stereo MicroScopes, Zoom-Master. Main products/instrumentation under R&D: Electro microscope and fittings.

2306

PRIVATE CONSULTANT BIOPHARMACEUTICAL PRODUCT DEVELOPMENT

Add: 9 Candle Lane East Brunswick, NJ 08816 Tel: (732) 257-2412 Fax: (732) 257-2931 President: John A. Bontempo, Ph.D. R&D expertise: Biopharmaceutical product R&D of proteins, peptides, monoclonal antibodies and other therapeutics focusing on preformulations, formulations, stability, scale-up, technology transfer to manufacturing, contract manufacturing, and regulatory compliance. Protein characterization, analytical development, pharmaceutical and parenteral technology, sterilization technology, preservatives, applications to multidose formulations. Technological expertise: MAE, P, PC, AB, PI, PPAT, PS, P/PS, PIS. Principal products/instrumentation: Biopharmaceuticals Main products/instrumentation under R&D: Protein anabolic hormone, protein carrier, protein chip, protein drugs, monoclonal antibodies against hepatitis virus.

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PRISM PHARMACEUTICALS

Web site: www.probiogen.de President: Dr. U. Marx; Alexander Nagel

Add: 11035 Roselle Street San Diego, CA 92121 Tel: (619) 625-0100 Fax: (619) 625-0050 E-mail: [email protected] Web site: www.prismpharma.com President/CEO: Steven C. Mendell Research director: Andrew Baird, Ph.D. R&D expertise: R&D and production of growth factors as targeting agents fused to therapeutic agents, DNA or toxins. R&D collaboration: Pharmacia & Upjohn; Chiron. Key license and trade contracts: Whittier Institute for Diabetes and Endocrinology, Salk Institute, Erbamont Farmatalia, Carlo Erba SRL. Technological expertise: Q, RD, P/S, C/TC, D-D, AB, DD, HTDS Principal products/instrumentation: Growth factors, DNA, toxins. Main products/instrumentation under R&D: R&D stage drugs, preclinical stage products for coronary artery restenosis, secondary lens clouding post cataract surgery, certain cancers, growth factors as targeting agents, compositions containing nucleic acid and ligands. Sealed and granted patents: Compositions containing nucleic acids and ligands for therapeutic treatment. 7,138,381, U.S; other patents pending.

Research director: Dr. U. Marx R&D expertise: Contract research/manufacturing and bioprocess development of mammalian cell derived products, proteins, biomass, etc. R&D collaboration: Diabetes Forschungsinstitut Duesseldorf. Technological expertise: F, TE, BA, CB, C/TC, H/CF, P/S, PMC Principal products/instrumentation: Contract manufacturing products, diagnostics, pharmaceuticals, several monoclonal antibodies for in vitro diagnostic purposes. Main products/instrumentation under R&D: Human monoclonal antibody against alphatoxin from Staphylococcus aureus, preclinical; mammalian cell derived proteins.

2309

PROCEPT INC

Add: 840 Memorial Dr. Cambridge, MA 02139 Tel: (617) 491-1100 Fax: (617) 491-9019 President/CEO: Stanley C. Erck Research director: James C. Jenson, Ph.D. R&D expertise: Research/development/manufacture/marketing of small molecule drugs based on receptors CD2, CD4 and TCR which can be used to treat autoimmune diseases, organ transplant rejection, and AIDS. R&D collaboration: Bristol-Myers Squibb.

2308

PROBIOGEN GMBH

Add: Goethestrasse 54, 13086 Berlin/Weissensee, Germany Tel: (49) 30-924-0060 Fax: (49) 30-924-0619 E-mail: [email protected]

Key sales market contracts: Bristol-Myers Squibb. Technological expertise: F, Q, RD, P/S, H/CF, C/TC, CH/S, SY, D-D, GA, SMC Main products/instrumentation under R&D: Compounds for the treatment of immune system disorders, such as AIDS and autoimmune

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disease, in clinical trials; small molecule drugs based on receptors CD2, CD4 and TCR.

2310

PROCESSALL, INC.

Add: 10596 Springfield Pike, Cincinnati, OH 45215-1138 Tel: (513) 771-2266 Fax: (513) 771-6767 E-mail: [email protected] Web site: www.processall.com President/CEO: Albert J. Shohet R&D expertise: Manufacture/development and marketing of process equipment — mechanically fluidized mixers, dryers and chemical reactors.

721

of new biotechnology medicines for the biopharmaceutical industries. Technological expertise: CC, E, F, TE, LP, BA, BS, C/TC, DD, PIS, PMC, P/S, SMC, SY, ET Principal products/instrumentation: Biologicals, biomaterials, clinical tests, contract manufacturing products, contract research/clinical trial products, diagnostics, enzymes, single cell proteins, vaccines, specialty chemicals, monoclonal antibodies, plastics, process validation. Main products/instrumentation under R&D: New biotechnology medicines, new drug delivery system.

2312

PROCHEM, INC.

Technological expertise: BA, PMC

Add: 826 Roosevelt Rd. Rockford, IL 61109

Principal products/instrumentation: Mixmill — mechanically fluidized mixers, UMax® — rotary vacuum dryers, Prestovac® — chemical reactors, Tilt-A-Mix® — pilot plant processors.

Tel: (815) 398-1788

Main products/instrumentation under R&D: Dryers and chemical reactors, CVDR.

Research director: Gerald Friend

Sealed and granted patents: Tilt-A-Mix processors (multipurpose mixers), CVDR (continuous vacuum dryers and reactors), other patents pending.

2311

PROCESS FACILITIES, INC.

Add: 160 Federal St. Boston, MA 02110 Tel: (617) 946-9400

Fax: (815) 398-1810 Web site: www.prochemweb.com President: Reno L Novak R&D expertise: R&D and production of custom synthesis on biochemicals Technological expertise: SY, PPAT, P/PS, P/P, PC Principal products/instrumentation: Chaps, ninhydrin, non-ionic detergents, PEGS, crosslinking detergents, protein modifiers, purified cryoprotectants, heterobifunctional reagents, reinecke salt, biotinylation reagents. Main products/instrumentation under R&D: Custom synthesis on specialty biochemicals.

Fax: (617) 946-9777 E-mail: [email protected] Web site: www.processfacilities.com President/CEO: Daniel J. Mariani R&D expertise: Engineering, design, construction, development and process validation

2313

PROCHROM S.A.

Add: B. P. 9 5, Rue Jacques Monod F-54250, France Tel: (33) 03-8331-2244

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Fax: (33) 03-8331-2051.

2315

PROCREA BIOSCIENCES, INC.

President: Pierre Hilaireau, Ph.D. Research director: Henri Colin, Ph.D. Subsidiary of Millipore Corp. R&D expertise: Development, design, preparative and production of scale chromatography: HPLC, GC, SFC and SMB.

Add: 1361 Beaumont Ave. Ste. 301, MountRoyal, Quebec H3P 2W3, Canada Tel: (514) 345-8535 Fax: (514) 345-8978 E-mail: [email protected]

Technological expertise: CC, LP, PIS, CH/S

Web site: www.procrea.com

Principal products/instrumentation: Biologicals, antibodies, specialty chemicals, enzymes, monoclonal antibodies, scale chromatography, single cell proteins, vaccines.

CEO: Dr. Pierre Miron, M.D., FRCSO

Main products/instrumentation under R&D: Various scale new chromatographies. Subsidiary bodies: Indianapolis, INC.

2314

PROCLINICAL PHARMACEUTICAL SERVICES, INC.

Add: 300 Kimberton Rd., Phoenixville, PA 19460

Research director: Patrice Hugo, Ph.D. R&D expertise: R&D of reproductive medicine (fertility and genetics); related novel products, manufacture. Technological expertise: Q, GA, GT, G. Principal products/instrumentation: Paternity test, (Paternitest), reproductive medicines. Main products/instrumentation under R&D: Endometriosis Dx test, fertility factor, fertinex. Subsidiary bodies: Division of Research and Development, 6100 Royalmount, Montreal, Quebec, Canada H4P2R2; PROCREA Quebec Inc., 5600 des Galeries Blvd., Ste. 401, Quebec, G2K 2H6.

Tel: (610) 935-4300 Fax: (610) 935-4301

2316

PROCTER & GAMBLE

E-mail: [email protected] Web site: www.proclinical.com President: Robert Gettis R&D expertise: Drugs clinical packaging design, analytical testing research, formulation development and manufacturing, labeling, storage, distribution, etc. Principal products/instrumentation: Contract manufacturing pharmaceuticals.

Add: 1 Procter & Gamble Plaza Cincinnati, OH 45202 Tel: (513) 983-1100 Fax: (513) 562-4500 Web site: www.pg.com President: John E. Pepper

Main products/instrumentation under R&D: Drugs clinical packaging, analytical testing method.

R&D expertise: R&D of immunodiagnostics, immunoassays, antisense technology, therapeutic enzymes/enzyme inhibitors, antivirals, and specialty chemicals; novel products manufacture.

Subsidiary bodies: Two sites in the U.S. and global partners in U.K.

Joint ventures: Advanced Tissue Sciences human tissue system to screen oral drugs.

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Technological expertise: E, ET, ERT, AS R&D collaboration: Allelix — capillary immunoassays. Key sales market contracts: Cygnus Therapeutic Systems — smoking cessation products. Key license and trade contracts: Advanced Tissue Sciences — in vitro assay for testing products for eye safety. Main products/instrumentation under R&D: Olestra™ calorie-free saturated fat replacement for food — filed for FDA approval; Mesalamine — inflammatory bowel syndrome associated with HPV infection, AIDS, ARC, Phase I/II; Pexelizumab, treatment for acute myocardial infarction, Phase III, 2008.

723

Sealed and granted patents: ANA monoclonals, PSP Prostate Cancer Rx; Pharmaceutical preparations and methods for inhibiting tumors. 7,053,058 U.S.

2318

PROCYTE CORP.

Add: 147 Keystone Drive, Montgomeryville, PA 18936 Tel: (215) 619-3600 Fax: (215) 619-3208 E-mail: [email protected] Web site: www.procyte.com President/CEO: Jack Clifford Research director: Leonard Patt, Ph.D.

2317

PROCYON BIOPHARMA, INC.

Add: 1650 Trans-Canada, Ste. 200, Montreal Quebec H9P 1H7 Canada Tel: (514) 685-9283 Fax: (514) 685-5138 E-mail: [email protected] Web site: www.procyonbiopharma.com President/CEO: Dr. Chandra Panchal Research director: Toney Ilenchuk, Ph.D. R&D expertise: Fundamental and applied research of biopharmaceuticals and clinical diagnostics; biopharmaceutical product and cancer therapeutics manufacture. R&D collaboration: London Regional Cancer Centre. Key license and trade contracts: University of Toronto, University of Manitoba, Massachusetts General Hospital. Technological expertise: Y, GT, S, PPAT, MAE Main products/instrumentation under R&D: Peptides and monoclonal antibodies for cancer, methods for inhibiting tumors.

R&D expertise: Development, manufacture and marketing of copper therapeutics for wound care, tissue repair and related novel medical therapies. Key sales market contracts: Bard Medical; Amuchina. Key license and trade contracts: Tanox, E Merck; Neutrogena, osmotics. Technological expertise: PIS, C/TC, SY, D-D, DD Principal products/instrumentation: Contract manufacturing products, Tricomin®, OsmoCyte®, TiSilc™, GraftCyte™, Gelica™, Iamin®, Complex Cu3™, Neova™. Main products/instrumentation under R&D: Copper therapeutics for wound care, tissue repair.

2319

PRODUCT SAFETY LABS

Add: 2394 Highway 130, Suite E, Dayton NJ 08810 Tel: (732) 438-5100 E-mail: [email protected]

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Web site: www.productsafetylabs.com

2321

PROGEN BIOTECHNIK GMBH

President: Ralph Shapiro, Ph.D. Research director: Gary Wnorowski, B.A. R&D expertise: Contract R&D of toxicology; consulting toxicologists; R&D of pharmacology/ safety pharmacology (GI. CNS, cardiovascular, renal, anti-inflammatory); consulting pharmacologists; GLP/GMP analytic chemistry; laboratory consulting, etc. Joint ventures: Consultants.

Discovery

Research

Technological expertise: CH/S Principal products/instrumentation: Agriculture, biomaterials, special chemicals, contract research/clinical trial products, cosmetics, detergents, food processing, natural products, pesticides, biopharmaceuticals, plastics, veterinary products.

Add: Maaßstrasse 30,69123 Heidelberg, Germany Tel: (49) 6221-82-780 Fax: (49) 6221-82-7823 E-mail: [email protected] Web site: www.progen.de President: Hans A. Dresel, M.D., Ph.D. Research director: Hans A. Dresel, M.D., Ph.D. R&D expertise: R&D and production of immunodiagnostic and research reagents. Key sales market contracts: Baxter, Shield, Techno-clone, U & L. Key license and trade contracts: Roche, Medac. Technological expertise: PA, RD, GT, H/CF, PIS, P/S

2320

PROFILE DIAGNOSTIC SCIENCES, INC.

Add: 510 E. 73rd St., 2nd floor New York, NY 10021 Tel: (212) 249-1940 Fax: (212) 249-4021 President/CEO: C. G. Wang Research director: Angus G. Hepburn, Ph.D. R&D expertise: Development and manufacture/marketing of new biomedical diagnostic products.

Principal products/instrumentation: ELISAs for TBE, HANTA virus, vaccination management, diagnostics for coagulation and lipid metabolism. Main products/instrumentation under R&D: Tools for gene therapy research, immunodiagnostics, drug research reagents. Subsidiary bodies: Cytokeratin antibodies, cardiac actin antibody, desmoglein antibody.

2322

PROGENICS PHARMACEUTICALS, INC.

Technological expertise: Q, RD, P/S, GA, CH/S, SY

Add: 777 Old Saw Mill River Rd., Tarrytown, NY 10591

Principal products/instrumentation: Novel diagnostics, clinical tests, environmental products, instrumentation.

Tel: (914) 789-2800

Main products/instrumentation under R&D: Diagnostic kits, diagnostic iodotope, diagnostic enzymes.

Fax: (914) 789-2817 E-mail: [email protected] Web site: www.progenics.com President/CEO: Ronald J. Prentki

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Research director: Paul J. Maddon, M.D., Ph.D. R&D expertise: R&D and manufacture of therapeutic products for human viral disease, HIV, cancer, etc. Joint ventures: American Cyanamid; Research and Development Agreement on HIV; BMS, Roche, Cytogen. R&D collaboration: Cooperative Research and Development Agreement with the Centers for Disease Control to conduct research on products designed to inhibit the replication of HTV.

725

methods for inhibiting HIV-1 infection. 7,060,273, U.S.; nucleic acids encoding polypeptides of anti-CCR5 antibodies. 20080015348, U.S.

2323

PROGEN INDUSTRIES LIMITED

Add: P.O. Box 2403, Toowong, Queensland 4066, Australia Tel: (61) 7-3842-3333 Fax: (61) 7-3720-9624 E-mail: [email protected]

Key sales market contracts: DuPont, NENQuest drug discovery system and HIV research reagent, Intracel.

Web site: www.progen.com.au

Key license and trade contracts: Columbia University, CD4-based AIDS therapeutics, Sloan-Kettering Cancer Center.

R&D expertise: R&D and manufacture of biopharmaceuticals; contract development services to cGMP, bulk protein; biotechnology medicines and vaccines manufacture.

Technological expertise: Q, SMC, RD, P/S, GA, H/CF, C/TC, CH/S, D-D, GT Principal products/instrumentation: NENQuest HIV gpl20-CD4 drug discovery system, soluble CD4 research reagent. Main products/instrumentation under R&D: MGV vaccine ganglioside antigen, treatment of various cancer including colorectal, gastrointestinal, lymphoma, small-cell lung cancer; therapeutics: PRO 367 for HIV infection, Phase II; HIV research reagents, PRO 542 for HIV infection, Phase II/III; vaccines, diagnostics and prophylactics for HIV infection, Phase I, cancer vaccines; GMK vaccine, for prevention of recurrence following surgery to remove primary melanoma, Phase III,2008; drug discovery system, methods for inhibiting HIV-1 infection. Sealed and granted patents: Compositions and methods for inhibition of HIV-1 infection. 7,138,119, U.S.; uses of DC-SIGN and DCSIGNR for inhibiting hepatitis C virus infection 7,022,323. U.S.; stabilized viral envelope proteins and uses thereof. 7,022,324 U.S.;

President: Alan Scott Research director: Robert Don, Ph.D.

Technological expertise: E, F, LP, BA, CB, C/TC, PMC, P/S, RD Principal products/instrumentation: Specialty chemicals, vaccines, enzymes, single cell proteins, Bulk-Proteins. Main products/instrumentation under R&D: Pl-88, Phase I; reagents, novel biotechnology medicines. Sealed and granted patents: Pl-88, pgm.

2324

PROGENITOR, INC.

Add: 4040 Campbell Ave. Menlo Park, CA 94025 Tel: (650) 617-0880 Fax: (650) 617-0883 President/CEO: Douglass B. Given, M.D., Ph.D. Research director: Lawrence K. Cohen, Ph.D. R&D expertise: Fundamental/applied R&D of functional genomics; novel products manufacture.

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R&D collaboration: Chiron Corp.; Novo Nordisk A/S; Affymetrix, Inc.; Pangea Systems, Inc., Cambridge Antibody Technology Ltd.

disease, anti-breast cancer, anti-fungals, etc., therapeutics, drug discovery products based on targets.

Key license and trade contracts: Amgen, Inc., SmithKline Beecham Clinical Laboratories. Technological expertise: Q, T, C/TC, PA, TE, BI, GT, RD, GA Main products/instrumentation under R&D: Antibodies, organ transplants/culture products, Leptin receptor (clinical); hereditary hemochromatosis gene diagnostic (clinical); red blood cell growth factor (preclinical); del-1 gene for angiogenesis, osteogenesis (preclinical); T7T7 nonviral gene delivery system for cancer and other applications (preclinical); bioinformatics; C18 gene for cardiovascular disease, HFE gene for iron loading disorders and cancer. Sealed and granted patents: Leptin receptor, yolk sac stem cells for gene delivery, T7T7 nonviral gene delivery system, EPM1 epilepsy gene.

2325

PROLIFIX, LTD.

Add: Milton Park 91, 4RY Abingdon, Oxon OX14 4RY U.K. Tel: (44) 1235-443-737 Fax: (44) 1235-443-744

2326

PROLINX, INC.

Add: 22322 20th Ave. SE Bothell, WA 98021 Tel: (425) 487-3401 Fax: (425) 487-9578 CEO: James Mahoney Research director: Robert Kaiser R&D expertise: Development of tools for genomics and proteomics; related novel products manufacture. Key license and trade contracts: Nanogen, Systemix, Invitrogen. Technological expertise: Q, SMC, G, P/S, P/P Principal products/instrumentation: Proteoplast, contract manufacturing products, RapXTract Dye Terminator Removal Kit, Versalinx Chemical Affinity Tools. Main products/instrumentation under R&D: New biomolecular purification and analysis products, complexing reagents, tools for genomics and proteomics research. Sealed and granted patents: Boronic, phenylboronic and phenyldiboronic compound complexing reagents and complexes.

E-mail: [email protected] Research Thangive

director:

Prof.

Nicholas

La

R&D expertise: Applied research of drug discovery based on targets which regulate the cell cycle; novel drugs development/ manufacture. R&D collaboration: Chugai Pharmaceuticals Co Ltd. Technological expertise: Q, T, PIS, AF, BI, C/TC, COC, CH/S, D-D, HTDS, RD, R, SMC Main products/instrumentation under R&D: Anti primary-cancer and other proliferative

2327

PROMEDDX, LLC.

Add: 10 Commerce Way, Norton, MA 02766 Tel: (508) 285-7877 Fax: (508) 285-7122 E-mail: [email protected] Web site: www.promeddx.com President: Jim Sperzel R&D expertise: Contract R&D/manufacture of biotechnology medicines. Technological expertise: CS, BTS, C/TC, E

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Principal products/instrumentation: Contract research/clinical trial biopharmaceuticals, patient recruitment for in vitro diagnostic clinical studies biological repository. Subsidiary bodies: 7,000 sq ft facility.

2329

727

PROMETIC BIOSCIENCES, INC.

Add: 500 Cartier Blvd. West, Suite 150, Laval, Quebec H7V 5B7, Canada Tel: (450) 781-1394 Fax: (450) 781-1403

2328

PROMEGA CORPORATION

E-mail: [email protected] Web site: www.prometic.com

Add: 2800 Woods Hollow Rd. Madison, WI 53711

President/CEO: Pierre Laurin

Tel: (608) 274-4330

R&D expertise: Design, development and manufacture/marketing of affinity processing media for the purification of therapeutic proteins.

Fax: (608) 277-2516 Web site: www.promega.com President/CEO: William Linton Research director: Dr. Josephine Grosch R&D expertise: Development of research reagents, clinical/industrial products, genetic identity, DNA purification/sequencing, neuroscience, molecular biology and signal transduction; related novel products manufacture. Joint ventures: Two in the People’s Republic of China (Shanghai, Beijing) Technological expertise: E, F, PA, Q, P/S, RD, SY, AB Principal products/instrumentation: Wizard™ DNA Purification Systems, TNT® Coupled Transcription/Translation Systems, Gene Print™ STR Systems, Luciferase Technologies, pGEM® plasmid, Riboprobe® Systems, R Nasin® Ribonuclease Inhibitor. Antibody-free Chip, 2008; ONE-Glo™ Luciferase Assay Reagent for bioluminescence-based assays, 2007; Kinase-Glo® Plus Screening Assay, 2007. Main products/instrumentation under R&D: Cytokine antibodies for prevention/treatment of inflammatory bowel disease. Sealed and granted patents: Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease. 6,663,864, U.S.; other patents pending.

Research director: Steven Burton, Ph.D.

Joint ventures: Affinity Chromatography Ltd. and Prometic Biosciences Ltd., U.K., Alpha One Pharmaceuticals, Inc., U.S.A. R&D collaboration: Novo Nordisk, Denmark; Convatec (BMS), U.K.; Delta Biotech (Centeon) U.K.; Institute of Biotechnology; Cambridge University, U.K. Key license and trade contracts: BTR/ DuPont; Institute of Biotechnology, Cambridge Univ. U.K.; Monogel. Technological expertise: T, BA, COC, P/S, PC, P/PS, RPP Principal products/instrumentation: Synthetic Affinity Mimetic™ Ligands; Protein Isolation Kit for Sorbent Identification (PIKSI™), Synthetic Protein A — Mimetic™ A; PIKSI Screening Column Kits. Main products/instrumentation under R&D: Targeted protein affinity ligands, affinity processing media for the purification of therapeutic proteins. Subsidiary bodies: cGMP Manufacturing Facilities: Isle of Man, U.K. and Joliette, PQ, Canada; R&D Labs: Cambridge, U.K. and Montreal, Canada; Biotechnology Research Institute, 6100 Royalmount, Montreal, Quebec, Canada H4P 2R2, Tel: (514) 496-2115, Fax: (514) 496-2079.

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Sealed and granted patents: Synthetic Protein A, perfluorocarbon matrices.

Fax: (49) 6221-484-943 E-mail: [email protected] Web site: www.promocell.com

2330

PROMETIC BIOSCIENCES, LTD.

Add: 211 Cambridge Science Park, Milton Rd., Cambridge CB4 OWA, U.K. Tel: (44) 1223-420-300 Fax: (44) 1223-420-270 E-mail: [email protected] Web site: www.prometicbiosciences.com President/CEO: P. Laurin Research director: S. Burton, Ph.D. Wholly owned company.

subsidiary

of

parent

R&D expertise: Development, design and manufacture of intermediate products for biomedical industry and industrial purification of biologicals. Technological expertise: P, SMC, LP, DD, COC, BA, P/S Principal products/instrumentation: Contract research/clinical trial products, contract manufacturing products, Mimetic™ Affinity Media; Purabead™.

President: Dr. D. Hinz and D. Huettner R&D expertise: Cell and tissue culture with human cells; related novel products manufacture. Technological expertise: PA, C/TC, H/CF, DKHC Principal products/instrumentation: Normal human cells, serum albumin cytokines, growth factors, several antibodies, production of special media according to customer requirements, endothelial cell kits, fibroblast kits, melanocyte kits, smooth muscle cell kits, skeletal muscle cell test, human and animal sera, perfusion chamber system; “Easy to use” cell culture kits with normal human cells, serum-free media and defined cell culture media, antibodies. Main products/instrumentation under R&D: Cell and tissue culture with human cells.

2332

PRONEURON BIOTECHNOLOGIES

Add: Kiryat Weizmann 14 P.O. Box 277 NessZiona 74101, Israel

Main products/instrumentation under R&D: Intermediate products for industrial purification of biological.

Tel: (972) 8-940-9550

Subsidiary bodies: 6100 Royalmount, Montreal, Quebec, Canada, H4P 2R2; Unit 2, The Freeport, Balla Saila, Isle of Man, British Isles IM9 2AP; 4000 Blackburn Lane, Ste. 115, Burtonsville, Maryland 20866 U.S.A.

Web site: www.proneuron.com

2331

PROMOCELL BIOSCIENCE ALIVE GMBH

Add: Handschuhsheimer Landstr. 12 Heidelberg 69120 Germany Tel: (49) 6221-439-049

Fax: (972) 8 940-9560 E-mail: [email protected] President: Dr. Adrian Hard, Ph.D. R&D expertise: R&D of central nervous system regeneration and protection, cell therapy; research and development/manufacture of related novel products. R&D collaboration: Sheba Medical Center, Tel Hashomer, Israel; Rabin Medical Center, Petah Tikva, Israel. Technological expertise: TE, C/TC, PIS, P/S Main products/instrumentation under R&D: Autologous human macrophages; neuroprotective

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human T-cells; immune privilege factor; organ transplants/culture products, central nervous system regenerator.

R&D expertise: Development and production of homogenizers and other biomedical equipment.

Sealed and granted patents: Human macrophages, Human T-Cells, Immune Privilege Factor.

Technological expertise: BME

2333

PROPRIET

Add: Singleton Court Wonastow Rd. Monmouth, Gwent NP25 5JA U.K. Tel: (44) 1600-715-632

Principal products/instrumentation: Laboratory homogenizers. Main products/instrumentation under R&D: Biomedical lab equipment for drug research.

2335

PROSPEC-TECHNOGENE, LTD.

Fax: (44) 1600-715-674

Add: Weizman Science Park, P.O. Box 398, Rehovot 76103, Israel

E-mail: [email protected]

Tel: (972) 8-940-9471

President: Doreen Whitlock

Fax: (972) 8-940-9472

Research director: David Stafford

E-mail: [email protected]

R&D expertise: Design, development and manufacturing of luminometers for hygiene control.

Web site: www.prospec.co.il

Technological expertise: E, PA, P, RD, GA, P/S, BME, ET, ERT Principal products/instrumentation: Biomaterials, biosensors, in vitro toxicology testing products, natural products, pharmaceuticals, bioluminescence instrument (bioprobe) and associated test kits. Main products/instrumentation under R&D: Enzyme analysis of heart enzyme (preclinical); Specific detection of defined microbial types (Phase III), luminometer for hygiene control.

2334

PRO SCIENTIFIC, INC.

Add: 99 Willenbrock Rd., Oxford, CT 06478, U.S.A.

Research director: Dr. Ron Yakov R&D expertise: Development, design, manufacturing and marketing of E. coli-derived recombinant human growth factors and cytokines. Technological expertise: F, RD, BA, P/S, C/TC Principal products/instrumentation: Biologicals, contract manufacturing products, recombinant human growth factor, other cytokines. Main products/instrumentation under R&D: E. coli-derived recombinant human growth factors.

2336

PROTARGA, INC. (FORMERLY NEUROMEDICA)

Tel: (203) 267-4600

Add: 2200 Renaissance Boulevard, Suite 450. King of Prussia Pennsylvania 19406

Fax: (203) 267-4606

Tel: (610) 592-4000

E-mail: [email protected]

Fax: (610) 592-4001

Web site: www.proscientific.com

President/CEO: Nigel L. Webb, Ph.D.

President: Richard M. Yacko

Research director: Matthews Bradley, Ph.D.

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R&D expertise: R&D and manufacture of therapeutic agents that already received FDA approval for the treatment of life-threatening diseases and disorders. R&D collaboration: NCI and NIMH. Technological expertise: D-D, DD, SY Main products/instrumentation under R&D: Taxoprexin® DHA — paclitaxel for treatment of solid tumors, Phase II; clozoprexin™ DHA — clozapine for treatment of psychosis, preclinical; therapeutic agents for the treatment of life-threatening diseases and disorders. Subsidiary bodies: Laboratory in Exton, PA. Sealed and granted patents: 12 U.S. Patents issued to Protarga.

2337

PROTECH INTERNATIONAL, INC.

Add: 405 N. St. Mary’s, Ste. 900, San Antonio, TX 78205

Tel: (919) 474-0507 Fax: (919) 474-9407 President/CEO: Christopher H. Price, Ph.D. Research director: H. E. Allaudeen, Ph.D. R&D expertise: R&D of oral delivery of protein/peptide therapeutics; stabilization research of protein/peptides; development of biopolymer-based drug delivery systems and drug delivery into CNS; novel products manufacture. Technological expertise: DD, D-D, P/S, SMC, SY Main products/instrumentation under R&D: Oral delivery systems for insulin, calcitonin, growth factors, CNS drugs, etc; biopolymerbased drug delivery systems, drug delivery route into CNS.

2339

PROTEIN DESIGN LABS, INC.

Tel: (210) 229-1002

Add: 932 Southwood Blvd., Incline Village, NV 89451

Fax: (210) 229-1003

Tel: (775) 832-8500

E-mail: [email protected]

Fax: (775) 832-8501

Web site: protechinternational.com

Web site: www.pdl.com

President: C. David McCarthy

President: Jon S. Saxe

R&D expertise: R&D and manufacture of analytical equipment.

Research director: Gary Queen, Ph.D.

Technological expertise: H/CF, C/TC, DD, GA, GT Principal products/instrumentation: CUY21 Electroporator. Main products/instrumentation under R&D: Analytical chromatograph, analyzer for clinical medicine concentration.

R&D expertise: R&D and production of monoclonal and polyclonal antibodies. R&D collaboration: Hoffmann-La Roche, Sandoz, Yamanouchi, Kanebo, Mochida, Eli Lilly. Key license and trade contracts: Toagosei, Genetics Inst, Teijin, Ajinomoto, Sankyo, Biogen, IDEC, Medlmmune, Elan, Tanox.

NOBEX CORPORATION

Technological expertise: F, C/TC, RD, COC, D-D, H/CF, AB

Add: 617 Davis Dr., Suite 100, Research Triangle Park, NC 27709

Principal products/instrumentation: Zenapax® daclizumab, for prevention of acute kidney transplant rejection.

2338

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Main products/instrumentation under R&D: Smart™ (anti-L-selectin antibody), treatment for trauma, Phase III; Smart™ anti-CD3 HuM291 for psoriasis and kidney transplantation, Phase II/III, 2008; zenapax® (daclizumab) for psoriasis, neurologic, uveitis, liver transplantation, graft-versus-host disease, cancer, eye, skin, tropical spastic paraparesis, etc, Phase II/III, 2008; Humanized anti-CD33 (leukemia) antibody, Phase III/IV; HoffrnannLaRoche; human anti-HBV, Phase III; humanized anti-IL-4 antibody to treat asthma, humanized anti-CD3 (transplant, autoimmune diseases), Phase II; antibodies, preclinical; antibody for asthma, Phase II; Smart™ 1D1D antibody for non-Hodgkin’s B-Cell lymphoma, Phase II; Smart™ M195 (HuM195) for acute myeloid leukemia or myelodysplastic syndrome, Phase III/IV, 2008; YM-337, MAb, for treatment of platelet aggregation, Phase II/III. Subsidiary bodies: Manufacturing, 3955 Annapolis Lane, Plymouth, MN 55447, Tel: (612) 551-1778, Fax: (612) 551-1780. Sealed and granted patents: U.S. patents #5,585,089, #5,693,761, #5,693,762 (~2001), Humanized immunoglobulins. 7,022,500, U.S.; other patents pending.

2340

PROTEIN LABS, INC.

Add: 12688 Torrey Bluff Dr., Suite 202, San Diego, CA92130 Tel: (888) 933-7873

731

Principal products/instrumentation: Agriculture, biologicals, biomaterials, bioremediation, biosensors, contract research/clinical trial products, human genome project, natural products, reagents, purified protein. Main products/instrumentation under R&D: Protein purification strategies, protein purification products.

2341

PROTEIN PATHWAYS, INC.

Add: 1145 Gayley Avenue, Ste. 304 Los Angeles, CA 90024 Tel: (310) 208-8444 Fax: (310) 208-8004 E-mail: [email protected] Web site: www.proteinpathways.com President: Matteo Pellegrini, Ph.D. R&D expertise: R&D of bioinformatics, related products manufacture. Technological expertise: AF, BI, CH/S, D-D, G, PG Principal products/instrumentation: Biologicals, human genome project, pharmaceuticals, contract R&D products. Main products/instrumentation under R&D: Carrier, proteinic drugs, protein-peptide sequencer, protein data bank.

2342

PROTEIN POLYMER TECHNOLOGIES, INC.

E-mail: [email protected] Web site: www.proteinlabs.com President/CEO: Dr. F. A. Palida Research director: Dr. F. A. Palida R&D expertise: Research of protein purification strategies and in providing protein purification. Technological expertise: E, F, PI, PA, BA, CB, C/TC, G, HTDS, PIS

Add: 11494 Sorrento Valley Rd., San Diego, CA 92121 Tel: (858) 558-6064 Fax: (858) 558-6477 E-mail: [email protected] Web site: www.ppti.com President/CEO: J. Thomas Parmeter Research director: Dr. Joseph Cappello

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R&D expertise: R&D and production of synthetic proteins for drug delivery and new biomaterials for the biomedical industry enterprises. R&D collaboration: St. Jude Medical, DuPont, Kimberly-Clark, Lohmann GmbH, Johnson & Johnson, Ethicon, Inc. (J & J subsidiary). Key sales market contracts: Sigma Chemical, Promega, Stratagene, TechGen International, Interchim, Iwaki Glass Co., Ltd., Funakoshi Co., Cosmo Bio Co., Intermountain Scientific.

Key license and trade contracts: PMC — the rHA for the human influenza market and a number of companies — companies core technology. Technological expertise: F, RD, BA, D-D, P/S Principal products/instrumentation: Research proteins, serum-free insect cells.

Technological expertise: TE, C/TC, RD, DD, DK

Main products/instrumentation under R&D: Influenza rHAO vaccines (human and veterinary for prevention of influenza), Phase III, 2008; Growth factors, preclinical; rCEA, Phase I/II; Flubiok (rHA, HEPLISAV) for treatment of influenza, PhaseII/III, 2008; largescale purification technology.

Principal products/instrumentation: ProNectin™ F.

Sealed and granted patents: HA influenza (U.S. 5,762,939); many pending.

Key license and trade contracts: Telios Pharmaceuticals, Cellco, Inc.

Main products/instrumentation under R&D: Surgical adhesives and sealants, synthetic proteins for in vivo drug delivery, DNA constructs. Sealed and granted patents: DNA constructs, composition of matter, process; Synthetic proteins for in vivo drug delivery and tissue augmentation, 6,380,154, U.S.; peptides comprising repetitive units of amino acids and DNA sequence encoding the same. 6,355,776, U.S.; other patents pending

2344

PROTEIN SOLUTIONS, INC.

Add: 1224 West Main St., Charlottesville, VA 22903 Tel: (804) 817-7177 Fax: (804) 817-7178 E-mail: [email protected] President/CEO: Sheridan D. Snyder Research director: Robert P. Collins

2343

PROTEIN SCIENCES CORP.

Add: 1000 Research Parkway, Meriden, CT 06450 Tel: (203) 686-0800 Fax: (203) 686-0286 E-mail: [email protected] Web site: www.proteinsciences.com President/CEO: Daniel Adams Research director: Dr. Gale Smith R&D expertise: Biotechnology medicines deliver research (GeneXpress™) using Baculovirus, serum-free insect cells and largescale purification technology.

R&D expertise: R&D of dynamic light scattering, protein, molecular characterization and light scattering technologies, novel products manufacture. Technological expertise: CH/S, BME, PPAT, P/PS, PC Principal products/instrumentation: DynaPro™ Dynamic Light Scattering Instruments (patented); particle characterization. Main products/instrumentation under R&D: Dynamic light scattering technology, protein concentrate, protein mapping protein sequencer. Sealed and granted patents: DynaPro™ DynamicLightScattering.

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PROTEIN TECHNOLOGIES, INC.

733

President: James I. Garreb Research director: James I. Garrels

Add: 4675 South Coach Drive, Tucson, AZ 85714, U.S.A. Tel: (520) 629-9626 Fax: (520) 629-9806 Web site: www.peptideinstruments.com President/CEO: Ken Rainin Research director: Rodolfo Marquez R&D expertise: R&D and manufacture of bioorganic and electrofocusing equipment, bioprocess engineering products development. Key license and trade contracts: BioRad for OptiFocus buffers. Technological expertise: AB, COC, CH/S, DD, PIS, PMC, SMC, PI, SY, P/S, BME Principal products/instrumentation: Smallto-medium scale peptide scale-up instruments, peptide synthesizer for production of highpurity crude peptides, 2008; PS3-Peptide Synthesizer, Symphony® Bio-organic Synthesizer, Symphony®; Sonata® Pilot-scale Synthesizer, Cascade Combinatorial Reactor, Symphony Quartet® Bio-organic Synthesizer, MinipHor®. Main products/instrumentation under R&D: Powder activator, Matrix valves, IEF Buffers, Cascade reactor, bioorganic/electrofocusing equipment. Sealed and granted patents: Powder Activator; RF3 Patent; Matrix Value Patent; Buffer Patent; Cascade, combinatorial reactor.

R&D expertise: Research of protein databases for genomically characterized organisms, functional genomics, proteomics, bioinformatics and 2D electrophoresis; related products development/manufacture. Technological expertise: P/S, AF, BI, CH/S, P/PS, PPAT Principal producty/instrumentation: Yeast Database (YPD™), C. Albicans Proteome Database (CalPD ™), S. pombe Proteome Database (Pambc PD™), C. elegans Proteome Database (Worm PD™). Main products/instrumentation under R&D: Human Proteome Survey Database (HumanPSD™), G-Protein Coupled Reception Proteome Database (GPCR-PD™), protein databases for genomically characterized organisms.

2347

PROTEROS BIOSTRUCTURES GMBH

Add: Am Klopferspitz 19, D-82152 Martinsried, Germany Tel: (49) 89-700-7610 Fax: (49) 89-7007-6115 E-mail: [email protected] Web site: www.proteros.de President: Prof. Huber Research director: Dr. Torsten Neueteind

2346

PROTEOME, INC.

Add: 100 Cummings Center, Ste. 435M Beverly, MA 01915

R&D expertise: Contract applied research of protein structure determination and drug design, related novel products development.

Tel: (978) 922-1643

Key license and trade contracts: Max Planck Institute, Munich.

Fax: (978) 922-3971

Technological expertise: RD, CH/S, D-D

E-mail: [email protected]

Main products/instrumentation under R&D: Proteasen, preclinical, contract research/clinical

Web site: www.proteome.com

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trial products, non-natural amino acids, protein structure determination.

Fax: (615) 320-1212

Sealed and granted patents: Non-natural amino acids; device and method for treating a crystal by applying microdrops thereto. 20070160501, U.S.

President: Stuart Wallis

Web site: www.protherics.com Research director: Dr. Allen Miller Subsidiary of Protherics PLC. R&D expertise: R&D and production of immunotherapeutics and CAMD.

2348

PROTEUS MOLECULAR DESIGN, LTD.

Add: Beechfield House Lyme Green Business Park Macclesfield, Cheshire SKI 1 OJL U.K. Tel: (44) 1625-500-555 Fax: (44) 1625-500-666 E-mail: [email protected] President/CEO: David Gration Research director: Allan Miller Subsidiary of Proteus International PLC. R&D expertise: R&D and production of rational computer-aided molecular design of drugs for human health. Joint ventures: University College Dublin, University of Bristol. Key license and trade contracts: ML Labs, Janssen, Enfer.

R&D collaboration: EH. Faulding & Co. Ltd. Key sales market contracts: Swedish Orphan AB. Key license and trade contracts: Altana, Inc. Technological expertise: PA, HTDS Principal products/instrumentation: ViperaTAb — distributed in Scandinavia, contract manufacturing products. Main products/instrumentation under R&D: Crotalid antivenom — pre-licensing; anti-TNF antibody, Phase III trials; antidote for Trycylic overdose, Phase II; anti-digoxin overdose — pre-licensing; glucarpidase (voraxaze), Phase IV, 2008. Subsidiary bodies: Protherics PLC. (London and Masslesfield), Protherics Australasia.

2350

PROTOLOGICS

Technological expertise: D-D, CH/S, COC Principal products/instrumentation: GnRH Immunotherapeutic/immunocastration, Pharmaceuticals, vaccines.

Add: 1517 Reisterstown Rd., Ste 202 Baltimore, Pikesville, 21208 Maryland, U.S.A.

Main products/instrumentation under R&D: Immunotherapeutics, small organic molecules/therapeutic DNA binding drugs, rational computer-aided molecular design of drugs for human healthcare.

E-mail: [email protected]

2349

PROTHERICS, INC.

Add: 5214 Maryland Way, Suite 405, Brentwood, TN 37027 Tel: (615) 327-1027

Tel: (410) 415-7947 Web site: www.protologics.com President: Neil Farbstein Research director: Dr. Graham Reade R&D expertise: Consulting of drug, inventing new technologies and new product development, database consulting, custom reports, technology transfer. Technological expertise: GT, D-D, DD, AB Principal products/instrumentation: Custom reports, asthma gene therapy, nuclear transport

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oligo for ribozyrnes and antisense, atherosclerosis gene therapy, engineered super oxide dismutase, engineered ribozymes, engineering bacteria.

2351

PROTOPROBE, INC.

Add: 10437 W Innovation Drive, Ste. 328 Milwaukee, WI 53226-4815 Tel: (414) 774-2670 Fax: (414) 774-0767 E-mail: [email protected] Web site: www.protoprobe.com President: Randall J. Wagner

735

Technological expertise: PA, E, ERT, ET, AB Principal products/instrumentation: Agriculture, contract manufacturing products, natural products, veterinary health products, Provita Protect Response, Hoofsure, Lacteal Ruminant, advance silage inoculant, Prolyte Extra, Promist, Provita Biogrow, calf bolus, lacteal horse and foal, lacteal pig and piglet, colostrum, genetically modified, newborn lamb and newborn piglet. Main products/instrumentation under R&D: Probiotics for neonatal pig and lambs (preclinical), natural animal health products. Sealed and granted patents: Provita Protect for newborn calves.

Research director: Sara B. Hendrickson R&D expertise: Biomedical applied research and drug production services to biotechnology companies and research institutes. Technological expertise: F, PA, C/TC, G, H/CF, P/S, RD, SY Principal products/instrumentation: Biologicals, contract research/clinical trial products, diagnostics, process validation, reagents, specialty biochemicals. Main products/instrumentation under R&D: Biotech drug, biotherapeutics.

2352

PROVITA EUROTECH, LTD.

Add: 21 Bankmore Road, Omagh, County Tyrone, Northern Ireland, BT79 0EU, U.K. Tel: (44) 28-8225-2352 Fax: (44) 28-8224-1734 E-mail: [email protected] Web site: www.provita.co.uk President: Alan Patterson R&D expertise: Development, production and marketing of genetically modified natural animal health products.

2353

PROZYME, INC.

Add: 1933 Davis St., Suite 207 San Leandro, CA 94577-1258 Tel: (510) 638-6900 Fax: (510) 638-6919 E-mail: [email protected] Web site: www.prozyme.com President: E. J. Wegstein Research director: T. L. Legerton, Ph.D. R&D expertise: R&D and manufacture of high performance proteins and enzymes for diagnostic and scientific research. Key license and trade contracts: Stanford Phycobiliproteins License. Technological expertise: F, E, PA, RD, P/S, CB, HTDS, ET, ERT, PC, PPAT, P/PS Principal products/instrumentation: Contract manufacturing products, diagnostics, reagents, streptavidin, Streptavidinplus®, streptavidin conjugates (alkaline phosphatase and horseradish peroxidase), MAP™ alkaline phosphatase, Protein A, Protein A/G; Protein G and conjugates; beta-galactosidase (E. coli), coated magnetic microspheres, phycobiliproteins,

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protein separation standards, GlycoPro®, glycoenzymes, PhycoLink®, fluorescent reagents for high throughput screening.

R&D expertise: Research of lab automation for DNA sample prep with magnetic beads, related novel products manufacture.

Main products/instrumentation under R&D: High performance proteins and enzymes, high mobility group protein.

Technological expertise: P/S, R, AU, P/P, RD

2354

PSC CLINICAL, INC.

Add: 611 South Congress Avenue, Suite 450, Austin, TX 78704 Tel: (512) 828-6602 Web site: www.pscclinical.com President: Raime A. Tritt, M.D. Research director: Steven L. Boudreau Subsidiary of Physicians Specialty Corp. R&D expertise: Clinical research of pharmaceuticals. Joint ventures: 110 ENT Physicians, 130 Pediatricians, 8 Sleep Labs, Family Practice, Internal Medicine.

Principal products/instrumentation: DNA/ RNA automate isolation/purification systems. Main products/instrumentation under R&D: DNA/RNA automate isolation/purification systems to meet HTS, such as 96 to 384 throughput integrated with PCR, and also the Clean-up System after PCR before Sequencer, lab automation for DNA sample prep. Subsidiary bodies: PSS/Precision System Science, 1843-1, Yanokuchi, Inagicity, Tokyo 206-0812. Sealed and granted patents: Magtration Technology for micro volume control and reception of magnetic beads, reagents using with a magnet a disposable capillary tips in full automated systems.

2356

PSYCHIATRIC GENOMES, INC.

R&D collaboration: Pharmaceutical companies, contract research organizations.

Add: 12111 Parklawn Dr. Rockville, MD 20852

Technological expertise: C/TC, E, ET, F

Fax: (301) 770-1205

Main products/instrumentation under R&D: Contract research/clinical trial products, Phase I, II, III, IV of pharmaceuticals/biopharmaceuticals.

E-mail: [email protected]

2355

PSS AMERICA

Add: 250 Hogan Lane, Conway, AR 72034 Tel: (501) 327-6456 Fax: (501) 327-8301 E-mail: [email protected] Web site: www.pssamerica.com President/CEO: Hideji Tajima Subsidiary of PSS/Precision System Science Co., Ltd.

Tel: (301) 770-1201

President: Michael Palfreyman, Ph.D. R&D expertise: Consultants of newly formed genomics-based drug discovery, therapeutic drugs for a wide variety of psychiatric diseases through partnerships with pharmaceutical and using an integrated platform of genomicsbased technologies. Technological expertise: CW, DD, D-D, BI, BTC, G, GA. Principal products/instrumentation: Related biotechnology drug products. Main products/instrumentation under R&D: Therapeutic drugs of psychiatric diseases, integrated platform of genomics-based technologies.

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2357

PULNIX AMERICA, INC.

Add: 1330 Orleans Dr. Sunnyvale, CA 94089

737

Main products/instrumentation under R&D: Plasmid purification kits, antisense oligonucleotides, nucleic acid drug.

Tel: (408) 747-0300 Fax: (408) 747-0880

2359

Web site: www.pulnix.com President/CEO: Toshi Hori Research director: Toshi Hori

GERMFREE’S HIGH CONTAINMENT DIVISION (FORMERLY PURIFIED MICOENVIRONMENT)

Subsidiary of Takenaka Group Co. Ltd.

Add: 7435 N.W. 41st St. Miami, FL 33166

R&D expertise: Research and manufacture/ marketing of solid state CCD cameras for high resolution microscopy.

Tel: (800) 888-5357

Technological expertise: BME, SI Principal products/instrumentation: Contract manufacturing products, biomedical laboratory instrumentation. Main products/instrumentation under R&D: Solid state CCD cameras, high resolution microscopy.

2358

PURESYN, INC.

Add: 87 Great Valley Parkway. Malvern, PA 19355 Tel: (610) 640-0800

Fax: (386) 677-0442 E-mail: [email protected] Web site: www.purified.com President: Jerome J. Landy, M.D., Ph.D. R&D expertise: Development and manufacturing of biomedical laboratory equipment for biotechnology medicine research. Technological expertise: G, BME Principal products/instrumentation: Laminar flow biological safety cabinets, glove boxes, custom filtration and containment systems for the genetic engineering field. Main products/instrumentation under R&D: Biomedical laboratory equipment for biotechnology medicine research.

Fax: (610) 640-0808 E-mail: [email protected] Web site: www.puresyn.com. President/CEO: Dennis M. Flynn Research director: Anthony P. Green, Ph.D. R&D expertise: Research/manufacturing/ purification of contract biotechnology medicines. Technological expertise: F, LP, RD, AB, GT, P/S Principal products/instrumentation: PolyFlo® — an inert, irregularly shaped, nonporous polymer resin specifically designed to purify nucleic acids; antisense, plasmids.

2360

PYROSEQUENCING AB

Add: Vallongatan 1 Uppsala SE-752-28 Sweden Tel: (46) 18-565-900 Fax: (46) 18-591-922 E-mail: [email protected] Web site: www.pyrosequencing.com President/CEO: Erik Wallden Research director: Bjorn Ekstrom R&D expertise: Research of applied DNA analysis, development of reagents and software

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for genetically engineered drugs, related products manufacture. Technological expertise: Q, G, PG Principal products/instrumentation: PSQ™ 96 system for DNA analysis, Pyrosequencing™, contract research/clinical trial products, human genome project. Main products/instrumentation under R&D: Reagents and software for genetically engineered drugs. Sealed and granted patents: Several.

2361

QBIOGENE

Add: 2251 Rutherford Road Carlsbad, CA 92008

Main products/instrumentation under R&D: cGMP manufacturing viral vectors, nonradioactive procedure to sequence DNA. Subsidiary bodies: Carlsbad (CA); Strasbourg (France); Scotland. Sealed and granted patents: Method of staining nucleic acids detected by non-radioactive labeling and kit of reactants for carrying out the method. U.S./SN 5,073,483; method for labeling a nucleic acid probe and kit for carrying out said method. PA/SN 07/378,377; nonradioactive procedure to sequence DNA. PCT/ FR92/00232; electrophoresis device. U.S./SN 5,407,5522; method and apparatus for high security crypto-marking for protecting valuable objects. U.S./SN 5,139,812; other patents pending.

Tel: (800) 424-6101 Fax: (800) 334-6999 E-mail: [email protected] Web site: www.qbiogene.com

2362

QBIOGENE (U.K.)

President/CEO: Dr. Garth Cumberlidge

Add: Salamander Quay West Park Lane Harefield, Middlesex UB9 6NZ U.K.

Research director: Dr. Luc Peloquin

Tel: (44) 1895-453-700

R&D expertise: R&D of quantum biotechnologies, manufacture of novel and innovative research reagents of the highest quality for molecular biology and genome reorganization/ genomics research.

Fax: (44) 1895-453-705

Key sales market contracts: Bios Laboratories; BioSeparations; QED BioSciences.

Research director: Merl Hoekstra

Key license and trade contracts: National Research Council of Canada, National Cancer Institute (NIH), INRA-CNRS (France). Technological expertise: PA, C/TC, PIS, RD, GA, P/S, COC, GT, BME Principal products/instrumentation: SiteDirected Mutagenesis kits, sets of primers and non-radioactive labeled probes, restriction and modification enzymes, adenovirus expression system, yeast lytic enzyme, positive selection vector, auto fluorescent visualization proteins and baculovirus expression systems; Annex.

E-mail: [email protected] Web site: www.qbi.com President: Garth Cumberlidge R&D expertise: Applied R&D of genomics and proteomics; molecular tools manufacture. Technological expertise: T, GA, GT, G, RD, genomic DNA. Principal products/instrumentation: Biologicals, vaccines, reagents. Main products/instrumentation under R&D: Genomic DNA, genomic sequencing, proteomic sequencing. Subsidiary bodies: Contract manufacture products, cGMP custom facilities.

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2363

QED BIOSCIENCE, INC.

Add: 10919 Technology Place, Suite C, San Diego, CA 92127

2365

739

QIAGEN N.V. CO QIAGEN GMBH

Tel: (858) 675-2405

Add: Max-Volmer-Str., 4 Hilden D-40724, Germany

Fax: (858) 592-1509

Tel: (49) 2103-892-703

E-mail: [email protected]

Fax: (49) 2103-892-777

Web site: www.qedbio.com

E-mail: [email protected]

President: Eileen Skaletsky, Ph.D.

Web site: www.qiagen.com

Research director: Eileen Skaletsky, Ph.D.

CEO: Metin Colpan, Ph.D.

R&D expertise: Development of complete antibody products, custom antibody research and manufacture.

Research director: Ulrich Schriek, Ph.D.

Technological expertise: PA, P/S, C/TC, H/CF Principal products/instrumentation: Biologicals, contract manufacturing antibodies, reagents, protective antibodies. Main products/instrumentation under R&D: Complete antibodies, custom antibodies.

Subsidiary of QIAGEN. R&D expertise: R&D of bioprocess engineering, innovation-enabling technologies and products for the handling, separation and purification of nucleic acids (DNA and RNA). Joint ventures: EVOTEC Key license and trade contracts: Roche, Organon Technika, 3M. Technological expertise: R, Q, F, LP, BI, BA, CH/S, GA, P/S, RD, SY

2364

QIAGEN GENOMICS

Add: 1725 220th Street S. E., Suite 104, Bothwell, WA 98021 Tel: (425) 398-8140 Fax: (425) 398-3150 Web site: www.qiagengenomics.com Research director: Andreas Dusterhoft Subsidiary of QIAGEN. R&D expertise: R&D of high throughput SNP genotyping, DNA database and DNA sequencing comparison; related novel products manufacture. Technological expertise: Q, GA, G, P/S Principal products/instrumentation: Contract SNP genotyping, SNP discovery, DNA sequencing, DNA purification, DNA extractor, DNA intercalator. Main products/instrumentation under R&D: High throughput SNP genotyping.

Principal products/instrumentation: QIAGEN® Plasmid kits, QIAprep® miniprep kits, Rneasy® RNA purification products, vaccines, biologicals. Main products/instrumentation under R&D: Bioprocess engineering technologies, protein expression profiling. Sealed and granted patents: Protein expression profiling. 6,921,642, U.S.; other patents pending.

2366

QIAGEN PLASMID DNA CONTRACT MANUFACTURING SERVICES

Add: QIAGEN Strasse 1 40724 Hilden, Germany Tel: (49) 2103-291-2400 Fax: (49) 2103-292-2000

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E-mail: [email protected]

President: Bob Butchofsky

Web site: www1.qiagen.com

Research director: Jean-Mari Houle

R&D expertise: Contract development and manufacturing of plasmid DNA.

R&D expertise: R&D and manufacture of photodynamic therapy using light-activated drugs.

Technological expertise: F, P/S, GT Principal products/instrumentation: Contract manufacturing vaccines, contract manufacturing of plasmid DNA. Main products/instrumentation under R&D: Plasmid DNA construction, plasmid DNA purification, plasmid DNA replication.

2367

QIAGEN SEQUENCING SERVICES

Add: Max-Volmer-Strasse 4 Hilder 40724 Germany Tel: (49) 210-3291-2400 Fax: (49) 210-3292-2000 Web site: www.qiagen.com R&D expertise: R&D and production of contract DNA sequencing

Technological expertise: HTDS Principal products/instrumentation: Photofrin® — light activated drug approved for use in bladder cancer, light-activated protein. Main products/instrumentation under R&D: Visudyne™ (verteporfin, photosensitizer) for age-related mascular degeneration, other photodynamic therapy using light-activated drugs, photosensitizer.

2369

QNA INTERNATIONAL PTY, LTD.

Add: Suite 46, 45 Riversdale Road, Hawthorn, Victoria 3122, Australia Tel: (61) 3-9818-4351 E-mail: [email protected] Web site: www.qna-international.com

Technological expertise: Q, P/S, S, P/PS

President: Graham Thurston

Principal products/instrumentation: Contract DNA Sequencing, DNA-drug adduct, DNA drug complex.

R&D expertise: Commercialization development of Australian technology of drug design particularly in the U.S.A.; Assist research institutes and small companies to take their inventions to market.

Main products/instrumentation under R&D: Contract DNA sequencer, DNA unwinding protein.

2368

QLT PHOTOTHERAPEUTICS, INC.

Technological expertise: PA, RD, C/TC, H/CF Principal products/instrumentation: Contract R&D products., invention drug design program, commercialized technology of drug design.

Add: 887 Great Northern Way, Suite 101, Vancouver, BC, V5T 4T5 Canada Tel: (604) 707-7000 Fax: (604) 707-7001 E-mail: [email protected] Web site: www.qltinc.com

2370

Q-ONE BIOTECH, LTD.

Add: West of Scotland Science Park, Glasgow, Q-One Biotech Inc, Worcester, MA 01605, Scotland

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741

Tel: (44) 141-946-9999

Tel: (412) 257-3100

Fax: (44) 141-946-0000

Fax: (412) 257-3001

E-mail: [email protected]

E-mail: [email protected]

Web site: www.q-one.com

Web site: www.qorpak.com

President/CEO: A. G. Gormly

President: Robert Polecritti

Research director: Dr. Gillian Lees

R&D expertise: Development and manufacture of laboratory biomedical instrumentation.

R&D expertise: Contract drug testing, design and research/development services to the biopharmaceutical industry, specialized in testing and validations of human and veterinary products, GMP cell banking and production of gene therapy products and viral vaccines for early phase clinical trials. Joint ventures: Vector development with University of Glasgow. Technological expertise: RD, F, P/S, BA, GA, H/CF, C/TC, Q, PA, T, GT Principal products/instrumentation: Prokaryotic and eukaryotic cell banking, gene therapy (viral and non-viral), vaccines, plasmid DNA, viral vectors, cell-based products. Retrovirus detection methods including rodent, human, simian, ovine and avian species. Specialist human and bovine virus assays: HHV-6/7, EBV, foamy; papillomavirus, bovine polyomavirus; specialist ovine, porcine caprine virus assays. GMP cell banking, vector and plasmid production, and safety testing and production of gene therapy products; improved methods for viral purification for use in viral vector production. Main products/instrumentation under R&D: Gene therapy — new virus vectors; more sensitive and rapid virus assays for QC testing of biopharmaceuticals and transgenic animals. Subsidiary bodies: Q-One Biotech Inc., MA, U.S.A.

2371

QORPAK

Add: 1195 Washington Pike Bridgeville, PA 15017

Technological expertise: BME, C/TC Principal products/instrumentation: Contract manufacturing products, infectious/hazardous material shippers, Sturdeeseal™; Green Teflon Lined Closures, Qurpak Green™.

2372

QOSINA CORP.

Add: 150-Q Executive Dr. Edgewood, NY 11717-8329 Tel: (631) 242-3000 Fax: (631) 242-3230 E-mail: [email protected] Web site: www.qosina.com President: Stuart Herskovitz R&D expertise: Development and manufacture of disposable plastic components for drug research. Technological expertise: BME, C/TC Principal products/instrumentation: Contract manufacturing products, full selection of clamps, luers, caps, connectors, check valves, spikes, chambers, kit components and forceps, brushes, applicators, jars, scoops, spatulas, funnels and pipettes. Main products/instrumentation under R&D: Disposable plastic components for drug research.

2373

QTI

Add: P.O. Box 470 Salem Industrial Park, Bldg. 5 Whitehouse, NJ 08888

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Tel: (908) 534-4445

Tel: (44) 115-974-7474

Fax: (908) 534-1054

Fax: (44) 115-974-8494

E-mail: [email protected]

E-mail: [email protected]

Web site: www.qtionline.com

Web site: www.quadrant.co.uk

President: Catherine Bacon

CEO: Iain Ross

Research director: Dr. Paul Winslow

Research director: Dr. Terence Chadwick

R&D expertise: Contract testing, outsourcing analytical research and development.

R&D expertise: R&D of bioprocess engineering, licensing out proprietary formulation technology for drug stabilization and delivery; related products manufacture.

Technological expertise: CC, SMC, PMC, P/S Principal products/instrumentation: Agriculture, biologicals, biomaterials, fine chemicals, contract research/clinical trial products., cosmetics, diagnostics, natural products, pharmaceuticals, plastics, process validation.

2374

QUAD FIVE

Add: 361 Rothiemay Rd. Ryegate, MT 59074 Tel: (406) 568-2911 Fax: (406) 568-2307 E-mail: [email protected] Web site: www.quadfive.com President: Wiley Micks Research director: Wiley Micks R&D expertise: R&D of donor animal blood, sera, antibodies, etc., for animal cell culture media, IVO and vaccine manufacture. Technological expertise: CP, P/S, BA, C/TC Principal products/instrumentation: Sterile donor animal blood; sterile donor animal sera; sterile donor animal tissue, animal sera; affinity purified antibodies. Main products/instrumentation under R&D: Sterile donor animal cell culture media.

Major partners: Becton Dickinson; Biotest AG; Eldoncard AS. Joint Vetures: Microdose Technologies (called Q Dose), Elan corporation (called Quoral) Key license and trade contracts: Glaxo Wellcome — drug delivery; Roche Diagnostics and Becton Dickinson — diagnostic products; Pall Corporation — stabilized platelets; TaxterHealthcare — Factor VIII formulation; Life Technologies, Inc. — stabilized restriction enzymes. Technological expertise: P/S, DD, C/TC Principal products/instrumentation: Contract research/clinical trial products, diagnostics, pharmaceuticals, vaccines, veterinary products, monoclonal antibodies. Main products/instrumentation under R&D: Inhaled rapid acting insulin — preclinical; Synthocytes™ platelet substitute — preclinical; proprietary formulation technology for drug stabilization and delivery, stabilized restriction enzymes. Subsidiary bodies: 10,000 sq ft clinical production facility. Sealed and Granted Patents: Covering all aspects of technology.

2376 2375

QUADRANT HEALTHCARE PLC

Add: 1 Mere Way Ruddington, Nottingham NG11 6JS U.K.

QUALICON — A DUPONT SUBSIDIARY

Add: Bedford Building 3531 Silverside Rd. Wilmington, DE 19810

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Tel: (302) 695-5300 Fax: (302) 695-5301 E-mail: [email protected] Web site: www2.dupont.com/Qualicon/en_US/

743

Main products/instrumentation under R&D: Latex immunoassay for infectious diseases in the third world, rapid diagnostics for infectious diseases, rapid immunodiagnosis for infectious diseases.

President: James C. Porter Research director: Ken McKelvey Subsidiary of E.I. DuPont de Nemours & Co. R&D expertise: R&D of microbial screening technologies, related testing equipment production. Technological expertise: Q, C/TC, CH/S, GA, R, G Principal products/instrumentation: RiboPrinter® microbial characterization system, BAX™ for screening/salmonella; BAX™ for screening/E. coli BAX™ for screening/listeria monocytogenes. Main products/instrumentation under R&D: BAX™ for screening campylobacter jejuni/coli; BAX™ for screening cryptosporidium parvum, BAX™ screening system, BAX™ system PCR assay for screening GMO, microbial screening assay. Subsidiary bodies: Qualicon Europe, Ltd. Sealed and granted patents: 22 issued patents plus foreign equivalence embodied in Qualicon™ current and future products.

2377

QUALITY ANTISERA

Add: 29 Distillery Rd. Warwick, NY 10990 Tel: (845) 986-5268 Web site: www.qualityantisera.com President: L. Huchital

2378

QUALITY BIOLOGICAL, INC.

Add: 7581 Lindbergh Dr. Gaithersburg, MD 20879 Tel: (301) 840-9331 Fax: (301) 840-0743 E-mail: customerservice@qualitybiological. com Web site: www.qualitybiological.com President/CEO: Solomon Graham Research director: Ronald L. Brown, Ph.D. R&D expertise: Development and manufacture of biotechnology medicines. Key license and trade contracts: Sigma Chemical — QBSF. Technological expertise: Q, RD, C/TC, PG, P/PS, PPAT Principal products/instrumentation: QBSF™ serum-free media, contract manufacturing products, reagents, human genome project. Main products/instrumentation under R&D: Protein-free media, serum-free media for osteoclast, stem cell serum-free media, method for repopulating human bone marrow comprising culturing CD34+ cell. Sealed and granted patents: Method for repopulating human bone marrow comprising culturing CD34+ cells in a serum-free medium. 6,372,210, U.S.; other patents pending.

Research director: M. Huchital 2379

QUALITY BIORESOURCES, INC.

R&D expertise: R&D of rapid diagnostics for infectious disease in the third world; antisera producting.

Add: 1015 N.Austin St. Seguin, TX 78155

Technological expertise: PA, PIS, P/S, SY

Tel: (830) 372-4797

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Fax: (830) 372-4799

2381

E-mail: [email protected]

QUALTEK MOLECULAR LABORATORIES

Web site: www.qualbio.com President/CEO: Claudia C. Briel Research director: Dr. Ken Davenport R&D expertise: Contract manufacturing of drugs and diagnostics, etc. Technological expertise: C, PA, P/S, C/TC Principal products/instrumentation: Contract manufacturing products, cosmetics, detergents, diagnostics, food processing, natural products, pharmaceuticals, reagents, veterinary products, vaccines. Main products/instrumentation under R&D: Anti-allergic drug, antibacterial peptides, diagnostic enzymes.

2380

QUALITY MANAGEMENT, INC. DBA QMI

Add: 426 Hayward Avenue North Oakdale Minnesota 55128 Tel: (651) 501-2337

Add: 6483 Calle Real, Suite A, Santa Barbara, CA 93117 Tel: (805) 681-3200 Fax: (805) 830-6379 Web site: www.qmlabs.com E-mail: [email protected] President: Steve Bernstein, Ph.D. R&D expertise: Contract laboratory research of biopharmaceuticals. Technological expertise: PC, C/TC, PG Principal products/instrumentation: Contract manufacturing products, diagnostics, human genome project, immunohistochemistry and in situ hybridization assays in human and animal fissures, applied to target validation, diagnostic drug development and animal tissue testing.

2382

QUANTUM APPLIGENE

Fax: (651) 501-5797

Add: Parc d ‘Innovation Rue Geiler de Kaysersberg-BP Illkirch Cedex F-67402, France

E-mail: [email protected]

Tel: (33) 388-675-425

Web site: www.qmisystems.com

Fax: (33) 388-671-945

President/CEO: Darrell Bigalke

E-mail: [email protected]

Research director: Darrell Bigalke

President/CEO: Mike Saunders

R&D expertise: Aseptic sampling design/ development, transferring research of liquidspharmaceutical industry; related novel products manufacture

Research director: Hassan Chaabihi

Technological expertise: PMC Principal products/instrumentation: QMI Safe-Septum®. Main products/instrumentation under R&D: Aseptic sampling devices.

Subsidiary of Quantum Biotechnologies Inc. R&D expertise: R&D and manufacture of kits and reagents for molecular biology research. Key license and trade contracts: F. Hoffmann-La Roche Ltd; Basel, Switzerland, and Roche Molecular Systems, Inc.; Development, manufacture, application and marketing of Taq DNA polymerase, and other Roche patented

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enzymes, as well as other thermostable enzymes and enzyme containing kits.

Tel: (313) 873-0200

Technological expertise: E, F, AB, P/S, RD, GA, SY, ET, POS

President/CEO: Eugene I. Schuster

Principal products/instrumentation: Enzymes, kits, reagents and instruments for molecular biology, DNA probes and imaging system for in situ hybridization. Main products/instrumentation under R&D: DNA polymerase, thermostable enzymes, enzyme-containing kits.

2383

QUANTUM BIOPROBE

745

Fax: (313) 873-4935 R&D expertise: R&D of acquired antibodies and commercialize biotechnological products and processes. Key sales market contracts: Sumitomo Corp. Key license and trade contracts: Chiron. Principal products/instrumentation: Quadroma™ bispecific monoclonal antibodies. Main products/instrumentation under R&D: Quadroma™ for use in therapy and imaging; cross-linked hemoglobin for use as blood substitute, acquired antibodies.

Add: 26 Bis Rue Kleber Montreuil 93100 France Tel: (33) 1-4870-5500 Fax: (33) 1-4851-5990

2385

QUESTCOR PHARMACEUTICALS, INC.

E-mail: [email protected]

Add: 3260 Whipple Rd.,Union City, CA 94587

President: Stan Yakatan

Tel: (510) 400-0700

Research director: Chaabihi Hassan

Fax: (510) 400-0799

Subsidiary of Quantum Biotechnologies, Inc.

Web site: www.questcor.com

R&D expertise: R&D and manufacture of reagents and kits for genetic research.

Research director: Laura S. Lehman, Ph.D.

Technological expertise: PA, Q, C/TC, GA, GT, PIS, P/S, RD, BI Principal products/instrumentation: Protein expression systems, DNA cloning systems, purification kits, buffers, solutions for nucleic acids and molecular biology, modifying enzyme, auto-fluorescent proteins. Main products/instrumentation under R&D: Expression system, new reagents and kits for genetic research.

President/CEO: Charles J. Casamento R&D expertise: Discovery, design development and production of antiviral, anti-fungal and anti-cancer drugs. R&D collaboration: ARQULE. Key sales market contracts: Crinos, Dumex, Prodesfarma. Key license and trade contracts: Univ. of W, Dai Nippon, Roberts, EnzyMed. Technological expertise: PPAT, SMC, RD, C/TC, D-D, AF, HTDS Principal products/instrumentation: Emitasol®, Migrastat™.

2384

QUEST BIOTECHNOLOGY, INC.

Add: 321 Fisher Building, 3011 West Grand Blvd., Detroit, MI 48202

Main products/instrumentation under R&D: Novel drugs for treatment of viral and fungal infections and cancer; Emitasol, Phase III; Migrastat, Phase II; CPC-III (cellular therapy)

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for sickle cell olisease, Phase III, 2008; CPC211 (cellular therapy) for treatment of ischemic stroke and traumatic brain injury, Phase III, 2008.

2386

QUIDEL CORP.

Add: 10165 McKellar Ct. San Diego, CA 92121 Tel: (858) 552-1100 Fax: (858) 455-4960 E-mail: [email protected] Web site: www.quidel.com

Research director: Dr. Peter Hicks (Tel: (44) 131-451-2078) R&D expertise: Drug products development (early development and clinical development services), manufacture and commercialization, informatics. Technological expertise: CW, LP, PC Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trials products, in vitro toxicology testing, biopharmaceuticals. Subsidiary bodies: Pharmacogenics, pharmaceutical sciences and formulation, Phase I services, central laboratory services, clinical supplies, Phase II and III clinical trials.

Research director: Allan Pronovost, Ph.D. R&D expertise: R&D and manufacture of rapid diagnostics. R&D collaboration: Glaxo Technological expertise: E, F, PA, PMC, P/S, RD, SY, AF, BA, S, C/TC, CH/S, GA, H/CF Principal products/instrumentation: Biomaterials, diagnostics, in vitro toxicology testing, organ transplants/culture products, QuickVue hCG, Conceive hCG, QuickVue LH, Conceive LH, QuickVue H, Pylori test, QuickVue InLine Strep A, QuickVue Strep B, CARDs Strep A, CARDs Mono. Main products/instrumentation under R&D: New therapeutical products in the area of infectious disease, autoimmune disease, and fertility. All diagnostic, in nature.

2387

QUINTILES TRANSNATIONAL CORP.

2388

QUOREX PHARMACEUTICALS

Add: 1890 Rutherford Road, Suite 200. Carlsbad CA 92008 Tel: (760) 602-1910 Fax: (760) 602-1915 President: Robert Robb Research director: Jeffrey Stein R&D expertise: R&D and manufacture of anti-infective/anti-inflammatory agents. Technological expertise: D-D, COC, SMC, RD, AF, HTDS Principal products/instrumentation: Antiinfective drugs, anti-inflammatory agents, antiinflammatory analgesic, anti-inflammatory steroid.

2389

R&D SYSTEMS EUROPE, LTD.

Add: 5927 South Miami Boulevard Berrington Building Morrisville, NC 27560

Add: 19 Barton Lane Abingdon Science Park Abingdon, OX14 3NB, U.K.

Tel: (919) 998-2000

Tel: (44) 123-552-9449

Web site: www.quintiles.com

Fax: (44) 123-553-3420

CEO/Chairman: Dennis Gillings, Ph.D.

E-mail: [email protected]

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Web site: www.rndsystems.com President: Robert Carlson Subsidiary of Techne Corporation. R&D expertise: Research and manufacture of high quality biopharmaceutical products for biomedical research and diagnosis. Key license and trade contracts: Toray Fuji Bionics Inc. Technological expertise: PA, C/TC, AB, BS, P/PS, PS/AP, PPAT Principal products/instrumentation: Cytokine assays, proteins and monoclonal antibodies; adhesion molecule ELISAs, proteins and polyclonal antibodies. Main products/instrumentation under R&D: Further ELISAs and reagents for molecules involved in inflammation and the immune system.

747

Immunoassay for erythropoietin, Quantikine M (Murine immunoassays), Parameter, growth factors, adhesion molecules; Cell Isolation Kit: The new PlusCellect cell-isolation kits supply two antibodies, one for immunopurification and the other for immunophenotypical analysis. Cell isolation is done by positive selection, 2009.

2391

R & S TECHNOLOGY, INC.

Add: 350 Columbia Street P.O. Box 352 Wakefield, RI 02880-0352 Tel: (401) 789-5660 Fax: (401) 792-3890 E-mail: [email protected] Web site: www.septech.com President: Paul S. Schauer, Ph.D. Research director: Robert P. Ritacco

2390

R&D SYSTEMS, INC.

Add: 614 McKinley Place NE Minneapolis, MN 55413 Tel: (612) 379-2956

R&D expertise: R&D of bioprocess engineering, manufacturing/applications of pharmaceuticals, separation/preparative/process HPLC/ biochromatography, etc., research.

Fax: (612) 656-4400

Key Sales Market Contracts: Hitachi Instruments.

E-mail: [email protected]

Technological expertise: LP, P/S, CH/S, BA

Web site: www.rndsystems.com

Principal products/instrumentation: R&S zonator 200/800 benchtop preparative HPLC and biochromatography process systems, antibiotics, vaccines.

President/CEO: Thomas E. Oland Research director: Monica Tsang, Ph.D. Subsidiary of Techne Corp. R&D expertise: Development and manufacture of scientific research reagents (cytokines, growth factors, MMPs, adhesion molecules), laboratory research immunoassays, hematology controls and calibrators. Technological expertise: PA, Q, C/TC, GA, H/CF, P/S, RD, R Principal products/instrumentation: Quantikine HS (High Sensitivity) Immunoassays, Quantikine IVD (In vitro Diagnostic)

Main products/instrumentation under R&D: Prep continuous free-flow electrophoresis. Sealed and granted patents: Prep continuous free-flow electrophoresis, other patents pending.

2392

RAD CHEMICALS, LTD.

Add: Science-Based Industrial Park Kiryat Weizmann Rehovot 76326 Israel

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Tel: (972) 8-406-472 Fax: (972) 8-406-473 President: David Tsur (Managing Director) R&D expertise: Development/design and manufacture of several biochemicals and raw materials for pharmaceutical and biological industries.

R&D expertise: Research and production of diagnostics. R&D collaboration: Famitalia-Pharmacia, Ministry of Research, Italy; Technobiochip, Italy; Thomas Jefferson University, Philadelphia, PA; Bioresearch Ireland.

Technological expertise: COC, BP, RM

Key sales market contracts: Pharmagen, U.S.A.; Scotlab, U.K.

Main products/instrumentation under R&D: Specialty and other biochemicals, raw materials, contract R&D products.

Key license and trade contracts: Temple University, U.S.A., Thomas Jefferson University. U.S.A.

2393

RADLEYS DISCOVERY TECHNOLOGIES

Add: Shire Hill Saffron Walden, Essex CB11 3AZ U.K. Tel: (44) 179-951-3320

Technological expertise: Q, D-D, P/S, GA, C/TC, SY Principal products/instrumentation: CTRAK kit (14: 18), C-TRAK kit (9: 22), CTRAK kit Delta F 508. Main products/instrumentation under R&D: C-TRAK CF plus, C-TRAK PSA.

Fax: (44) 179-951-3283 E-mail: [email protected] Web site: www.radleys.com President: Russell Radley R&D expertise: Development and production for parallel and combinatorial chemistry, related novel products manufacture/marketing. Technological expertise: P/S, COC Principal products/instrumentation: Carousel Reaction Station, Lollipop PHBE Separator, Titan Pipe Micro Titer Phases, Greenhouse Parallel Synthesizer, combinatorial organic synthesis method.

2394

RAGGIO-ITAIGENE S.P.A.

Add: Via delle Antille, 29 Pomezia Roma 00040 Italy Tel: (39) 6-910-7494 Fax: (39) 6-910-7497 CEO: Giovan Battista Cozzone Research director: G. Martinazzo

2395

RAHAN MERISTEM LTD.

Add: Kibbutz Rosh Hanikra, Western Galilee 22825 Israel Tel: (972) 4-985-7100 Fax: (972) 4-982-4333 E-mail: [email protected] Web site: www.rahan.co.il President: Yohanan Furman R&D expertise: Research of plant tissue culture and advanced technologies for plantation/plant breeding, selection and propagation of crop plants, plant molecular genetics; novel products and plant-marker products development/manufacture. Technological expertise: Q, TE, T, P/S, RD Principal products/instrumentation: Tissue culture banana, strawberry, date palm, cut flowers, flowering plants. Main products/instrumentation under R&D: Labware, laboratory network, laboratory information management system, laboratory scale purification devices.

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2396

RAINDANCE TECHNOLOGIES.

2398

749

RANSOM HILL BIOSCIENCE, INC.

Add: 44 Hartwell Avenue Lexington, MA 02421 Tel: (781) 861-6300

Add: P.O. Box 219 Ramona, CA 92065

Fax: (781) 861-1233

Tel: (619) 789-9483

E-mail: [email protected]

Fax: (619) 597-8509

Web site: www.raindancetechnologies.com

E-mail: [email protected]

President: Diane Vince R&D expertise: Development/manufacture of biomedical laboratory instrumentation. Technological expertise: E, C/TC, ET, ERT Principal products/instrumentation: Handheld microplate immunoassay washer. Sealed and granted patents: Handheld microplate immunoassay washer.

2397

RAMOT, LTD.

Add: 32 Haim Levanon Street P.O. Box 39296 Tel Aviv 61392 Israel Tel: (972) 3-640-6675

President/CEO: Michael T. MacDonell, Ph.D. Research director: Michael T. MacDonell R&D expertise: Development and manufacture of custom DNA synthesis and DNA detection technique research. Technological expertise: P/S, SY, DK, RDS Principal products/instrumentation: Custom DNA probes and primers, DNA drug complex, DNA protein complex, DNA sequencer, DNA database. Main products/instrumentation under R&D: DNA synthesizer, DNA detection kits, DNA extractor.

2399

RAPP POLYMERE GMBH

Fax: (972) 3-640-6608 E-mail: [email protected] Web site: www.ramot.org President: Dr. Rami Finkler Subsidiary of Tel Aviv University R&D expertise: Technology transfer of TAU; applied (contract) research, licensing. Technological expertise: E, F, PIS, PA, RD, Q, SIM, TE, T, AF, AB, I, C/TC, DD, D-D, GT, H/CF Principal products/instrumentation: Biologicals, biomaterials, bioremediation, biosensors, contract research/clinical trial products, diagnostics, human genome project, pharmaceuticals, toxic waste processing, vaccines, technology transfer of biopharmaceuticals. Sealed and granted patents: Approximately 150 patents in different fields.

Add: Ernst-Simon-Str. 9 D 72072 Tübingen Germany Tel: (49) 707-176-3157 Fax: (49) 707-176-3158 E-mail: [email protected] Web site: www.rapp-polymere.com President/CEO: Dr. Wolfgang Rapp Research director: Dr. Wolfgang Rapp R&D expertise: R&D and manufacture of resins for combinatorial chemistry, peptide and nucleotide synthesis, HPLC, immunization schedule. Key sales market contracts: Nova Biochem, ABI, Fluka, ACT, Peptide Internationals, Merck. Technological expertise: P, SY, SMC, COC, R, P/S, PI, CS

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Principal products/instrumentation: Semiautomated synthesizer; TentaGel®; peptide synthesis resin TentaGel S; nucleotide synthesis resin TentaGel N; polymeric immunoconjugates TentaGel J; Resins for combinatorial chemistry, lipopeptide PEG-peptides. Main products/instrumentation under R&D: Combichem Synthesizer, resiniferatoxin, resin for peptide synthesis.

2400

RATHBURN CHEMICALS, LTD.

Add: Walkerburn Scotland EH43 6AU, U.K. Tel: (44) 189-687-0651

for the pharmaceutical and biopharmaceutical industries. Technological expertise: SMC, SY Principal products/instrumentation: Active biopharmaceutical ingredients, 5′-DMT blocked deoxynucleosides, nucleoside derivatives, N.N′-carbonyldiimidazole, contract manufacturing products. Main products/instrumentation under R&D: Active immunizing ingredients, advanced intermediates for the biopharmaceutical industries. Subsidiary bodies: cGMP pilot plant as well as cGMP commercial production facility.

Fax: (44) 189-687-0633 E-mail: [email protected] Web site: www.rathburn.co.uk

2402

RAYTEST ISOTOPENMESSGERATE GMBH

President/CEO: A.C. Mackay R&D expertise: Development and manufacture of solvents and reagents for biotechnology medicines.

Add: Benzstrasse 4 Straubenhardt D-75339 Germany Tel: (49) 070-829-2550

Technological expertise: P/S, SMC, SY

Fax: (49) 070-822-0813

Principal products/instrumentation: Laboratory research solvents, contract manufacturing products, natural products, nutraceuticals, solvents for biotechnology medicines, reagents for biotechnology medicines.

E-mail: [email protected]

2401

RAYLO CHEMICALS, INC.

Add: 8045 Argyll Rd. Edmonton, Alberta T6C 4A9 Canada Tel: (780) 468-6060 Fax: (780) 468-4784 President: Matthew Colomb Research director: Dr. Robin Nicol R&D expertise: Custom development and manufacture of active biopharmaceutical ingredients (APIs) and advanced intermediates

Web site: wwvv.raytest.de President: Gunter Dietzel Research director: Dr. M. Liebler R&D expertise: R&D of radiochromatography, bio-imaging and bioholography. related novel products manufacture. Key sales market contracts: Fuji BioImaging Group. Technological expertise: CH/F, HTDS, PG, SY, BI Principal products/instrumentation: Ramona (radio HPLC), Rita (radio TLC), Raga (radio GC), Steffi (radio LC, cooled CCD camera, high throughput screening, bioinvent. Main products/instrumentation under R&D: Bioimaging agent, radiochromatography column.

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2403

RAYTHEON COMPANY

751

President: Merritt Nesin

Add: 870 Winter Street Waltham, MA 024511449

R&D expertise: Development and manufacture of syringe, syringe burette, syringe pump and other biomedical laboratory instrumentation.

Tel: (781) 522-3000

Technological expertise: DD, BME

Fax: (781) 422-4522

Principal products/instrumentation: syringe pumps, syringe filter.

E-mail: [email protected] Web site: www.raytheon.com CEO: Charles Q. Miller, J.D.

Main products/instrumentation under R&D: Syringe, syringe burette, labware.

Research director: Robert A. Simmers Subsidiary of Raytheon Co. R&D expertise: Drug discovery, design, development, engineering, process scale-up, process validation, environmental biology and drug construction, etc., biotechnology drug R&D and manufacturing.

2405

REACTIVA S.A.

Add: Puig I Xoriguer, 12 Barcelona 08004 Spain Tel: (93) 329-2595 Fax: (93) 443-0668

Joint ventures: PerSeptive Biosystems, Separator.

E-mail: [email protected]

Key license and trade contracts: Chiyoda, technology transfer and pharmaceutical and biotechnology design expertise.

R&D expertise: Genetics fundamental/applied research, related products manufacture.

President: Jose Marco

Technological expertise: F, C/TC, PMC, CH/S, H/CF, LP, E, RD, P/S, BA

Technological expertise: GN, HI, H/CF, C/TC, COC, GA, G, HTDS

Principal products/instrumentation: Antibiotics, biologicals, single cell proteins, specialty chemicals, vaccines, enzymes, monoclonal antibodies.

Principal products/instrumentation: Tissue culture reagents; antibodies; Enzymes, organ transplants/culture products, vaccines, genetic resource, gene vaccines.

Main products/instrumentation under R&D: Drug antibodies, drug construction analysis.

Main products/instrumentation under R&D: Gene transduction technique, genetic screening, genetic fingerprint.

Subsidiary bodies: Cambridge, MA; London, U.K.; Birmingham, UK; AL, U.S.A.

2406 2404

RAZEL SCIENTIFIC INSTRUMENTS, INC.

REACT SCIENTIFIC

Add: Unit 2, 69 Fullarton Drive Troon Ayrshire, U.K.

Add: P.O. Box 111 St. Albans, VT 05478

Tel: (44) 129-231-2171

Tel: (877) 324-9914

Fax: (44) 129-231-1224

Fax: (877) 524-2110

E-mail: [email protected]

E-mail: [email protected]

Web site: www.reactscientific.com

Web site: www.razelscientific.com

President: Allan Finlayson

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R&D expertise: R&D of biomedical laboratory supplies to biotechnology, genetics, scientific research, diagnostics, food sector. Key sales market contracts: NALGE/NUNC International, Cambio, TPC-Microflow, InterGen, Sartorius Separation, Atlas Clean Air Ltd., Osmonics Inc.

6,602,687, U.S.; Methods of modifying eukaryotic cells. 6,586,251 and 6,596,541, U.S.; Isolating cells expressing secreted proteins. 6,919,183, U.S.; Methods of modifying eukaryotic cells. 7,105,348, U.S.; Receptor based antagonists and methods of making and using. 7,083,949, U.S.

Technological expertise: RD, BA, C/TC, PIS Principal products/instrumentation: Molecular biology separation devices. Main products/instrumentation under R&D: Gene transduction technique, genetic typing, genetic variation, genetic screening.

2408

REALEF S.A.R.L.

Add: 10, rue de la Cour des Noues Paris 75020 France Tel: (33) 146-363-656 Fax: (33) 146-363-544

2407

READE ADVANCED MATERIALS

President: Pierre Girard-Stein

Add: P.O. Box 15039 Providence, RI 029150039

R&D expertise: Development and manufacture of diagnostic kits and biologicals for research.

Tel: (401) 433-7000

Technological expertise: AB, MAE, C/TC

Fax: (401) 433-7001

Principal products/instrumentation: Glycosylated hemoglobin, ELISA plate kits, monoclonal antibodies, cytokines, autoimmune diseases therapeutics.

E-mail: [email protected] Web site: www.reade.com President: Charles Reade R&D expertise: R&D, manufacturing custom processing of value added specialty chemicals.

Main products/instrumentation under R&D: Diagnostic enzymes, diagnostic kits, diagnostic reagents.

Technological expertise: C/TC, RD Principal products/instrumentation: Reade™ inorganic powders, Reade™ mineral powders, Reade™ nano powders, Reade™ additives and reinforcements. Subsidiary bodies: P.O. Box 12820, Reno, NV 89510, Tel: (775) 352-1000, Fax: (775) 352-1001; E-mail: [email protected] Sealed and granted patents: Methods of stimulating cartilage formation. 6,908,744, U.S.; Method for screening comprising cells expressing the CNTF receptor. 6,316,206, U.S.; Dorsal tissue affecting factor and compositions. 6,277,593, U.S.; DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby.

2409

REATEC GMBH

Add: Ahornweg 6, Weiterstadt D-64331 Germany Tel: (49) 615-015-864 Fax: (49) 615-015-760 E-mail: [email protected] Web site: www.reatec.de President: Dr. Burckhard Kraska R&D expertise: Development and production of biopharmaceuticals. Key sales market contracts: Dr. K. Hollborn & Sohne; EL1SA Technologies; Schuller GmbH.

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Technological expertise: CB, P/S, SY, BI

E-mail: [email protected]

Principal products/instrumentation: Biochemicals, specialty biochemicals, biological products, bioseparation carrier, biological stains.

Web site: www.ReesScientific.com

Main products/instrumentation under R&D: Complex saccharides, complex glycan, biosimilar drugs, biotech drug.

R&D expertise: R&D and production of PC-based monitoring and control systems for controlled environments in the scientific research, pharmaceutical, blood banking, and biotechnology industries.

2410

RECEPTOR BIOLOGY, INC.

Add: 10000 Virginia Manor Rd. Beltsville Maryland 20705 Tel: (301) 707-4200 Fax: (301) 210-6266 E-mail: [email protected] President: Dr. Jesse Baumgold R&D expertise: R&D and manufacture of cloned receptors for use in drug discovery; and provision of research/development full-scale services. Key sales market contracts: Research Biochemicals, Inc., Biolinks K.K. Technological expertise: RD, C/TC Principal products/instrumentation: Several subtypes of dopamine receptors, serotonin receptors, Somatic receptors, Visceral receptors, muscarinic receptors, cannabinoid receptors and many other receptors. Main products/instrumentation under R&D: A variety of other receptors that have utility as targets for pharmaceuticals, cloned receptors for drug discovery.

2411

REES SCIENTIFIC CORP.

Add: 1007 Whitehead Rd. Extension Trenton, NJ 08638 Tel: (609) 530-1055 Fax: (609) 530-1854

President/CEO: Rees Thomas, Ph.D. Research director: Rees Thomas, Ph.D.

Technological expertise: PMC, BS, BTS Principal products/instrumentation: Series II-PC Environmental Monitor/Alarm; Series II-PC Access Control; Micro 2000 Monitor; Informer and Informer 2400; Seer monitor and the satellite remote site monitor. Main products/instrumentation under R&D: PC monitoring and control systems for control of environments in drug research.

2412

REFERENCE DIAGNOSTICS, INC.

Add: 19 Crosby Dr. suite 30 Bedford, MA 01730-1401 Tel: (781) 276-9000 Fax: (781) 276-9002 E-mail: [email protected] Web site: www.ref-dx.com President/CEO: Joseph Lawlor, Ph.D. R&D expertise: R&D and production of IVD reagent Key sales market contracts: Polymedco, Inc., Denka Seiken Co. Ltd., Ortho-Clinical Diagnostics. Technological expertise: E, PA, SMC, P/S, ET, P/PS Principal products/instrumentation: LipiDirect® product line includes tests for LDLcholesterol and HDL-cholesterol using proprietary magnetic separation.

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Main products/instrumentation under R&D: IVD reagents, magnetic separation of lipoproteins. Sealed and granted patents: Magnetic separation of lipoproteins; other pending.

Sealed and granted patents: IL-1 receptor based cytokine traps. 6,927,044, U.S.; conditioned culture media. 20080078000, U.S.; other patents pending.

2414 2413

REGENERON PHARMACEUTICALS, INC.

REGIS TECHNOLOGIES, INC.

Add: 8210 Austin Ave. Morton Grove, IL 60053

Add: 777 old Saw Mill River Rd Tarrytown, NY 10591

Tel: (847) 967-6000

Tel: (914) 345-7000

E-mail: [email protected]

Fax: (914) 345-7797 E-Mail: [email protected] Web site: www.regeneron.com President/CEO: Leonard S. Schleifer, M.D., Ph.D. Research director: George Yancopoulos, M.D., Ph.D. R&D expertise: R&D expertise in growth factors and their mechanisms of action to discover and develop protein-based and small molecule drugs for the treatment of obesity and neurological, inflammatory, and muscle diseases, as well as abnormal bone growth, cancer, and angiogenesis; related novel drugs manufacture. R&D collaboration: Sumitomo Chemical, Procter & Gamble, Amgen, Medtronic, Sumitomo Pharmaceuticals. Technological expertise: F, Q, T, PA, D-D, RD, P/S, BA, GA, H/CF, C/TC, CH/S, DD, BI Principal products/instrumentation: Arcalyst (rilonacept) for treatment of cryopyrinassociated periodic syndromes(CAPS), 2008; conditioned culture media. Main products/instrumentation under R&D: Brain-derived neurotrophicfactor (BDNF), for treatment of amyotrophic lateral sclerosis, Phase I/II; NY-3, Phase I/II; neurotrophin-3 (growth factor) for enteric neuropathies, Phase II/III, 2008; Axokine® for obesity, Phase III, 2008.

Fax: (847) 967-5876 Web site: www.registech.com President: Louis Glunz, Ph.D. R&D expertise: Custom synthesis research and manufacture of complex organic compounds for the pharmaceutical and biotechnology industries. Chromatography products development for the separation of enantiomers and biomolecules. Key license and trade contracts: Purdue Research Foundation, Research Corp. Technology. Technological expertise: CC, SY, P/S, SMC, HTDS, COC, HC, OC Principal products/instrumentation: Rexchrom HPLC columns, chiral columns, derivatizing reagents for GC and HPLC, custom synthesis of fine organic compounds and complex organic compounds, RAM direct injection, HPLC columns, IAM drug discovery HPLC columns. Main products/instrumentation under R&D: Doyle catalyst, chromatography products, complex organic compounds for drug and biotechnology industries.

2415

REHEAT CO., INC.

Add: 10 School St P.O. Box 1, Danvers, MA 01923

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Tel: (978) 777-4441 Fax: (978) 777-7958 E-mail: [email protected] Web site: www.reheat.com President/CEO: Paul Meinerth Research director: Paul Meinerth R&D expertise: R&D and manufacture of heating and control equipment of process gases like nitrogen, oxygen, etc,; batch and process control; low temperature incubation. Joint ventures: Hotwatt Inc. R&D collaboration: Hotwatt Inc. Technological expertise: PMC, BME Principal products/instrumentation: Industrial and laboratory process heaters and controls, heating block systems, control heating systems. Main products/instrumentation under R&D: Low temperature heated plates and platens, heat exchanger.

2416

RELIABLE BIOPHARMACEUTICAL CORP.

Add: 1945 Walton Road P.O. Box 140192 St. Louis, MO 63114 Tel: (314) 429-7700 Fax: (314) 429-0937 E-mail: [email protected] Web site: www.reliablebiopharm.com President: Michael E. Zaleski

755

Key license and trade contracts: ISIS Pharmaceuticals, Inc. Technological expertise: E, LP, GA, AB, C/TC, D-D, P/S, SY, NAC Principal products/instrumentation: Enzymes, specialty chemicals, deoxynucleosides, GMP manufactured USP tested biochemicals, bulk pharmaceuticals, DMT protected 2′0-Meribonucleosides, PCR reagents, deoxynucleotide triphosphate. Main products/instrumentation under R&D: Anticoagulants (animal studies), anticoagulant, nucleic acid derivatives. Sealed and granted patents: Anticoagulant patents #5,589,588 and #5,714,598; other patents pending.

2417

RENATO FEDERICO RIVERA BATIZA PH.D.

Add: Encino Grande 19 A Tetelpan Del. Alvaro Orregon Mexico City 01700 Mexico Tel: (525) 585-0109 Fax: (525) 585-0109 President/CEO: Dr. Renato F. Rivera Batiza R&D expertise: Development, design, manufacture and marketing of reagents for clinical pathology, cell pathology and RIA. Technological expertise: C/TC, G, PG Contract Unit of Matket Sell: BioGenex Laboratories, San Ramon, CA, U.S.A.

Research director: Curt Mattenson

Key license and trade contracts: BioGenex Laboratories.

R&D expertise: R&D and manufacture of biochemicals, bulk pharmaceutical chemicals, nucleic acid derivatives and enzymes, specialty chemicals.

Principal products/instrumentation: Cell pathology technique, BioGenex, contract research/clinical trial products, diagnostics, instrumentations, reagents

R&D collaboration: National Institutes of Health and Washington University.

Main products/instrumentation under R&D: Reagents for cell pathology research.

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RENTSCHLER BIOTECHNOLOGY GMBH

Add: Erwin-Rentschler-Strasse 21 Laupheim 88471 Germany Tel: (49) 739-270-1555 Fax: (49) 739-270-1521 E-mail: [email protected] Web site: www.rentschler.de President: Dr. Nikolaus F. Rentschler Research director: Dr. Wieland W. Wolf R&D expertise: R&D and production of eucaryotic cell culture, interferons, cytocines, protein purification, formulation; biological drugs, clinical research, contract development, contract manufacturing, bioprocess, protein purification, biopharmaceuticals analytical research. R&D collaboration: Cooperation contract with Schering AG, Berlin, for the development of a recombinant interferon beta product. Technological expertise: F, RD, BA, C/TC, P/S

Research director: Marcia Ruiz R&D expertise: Development and applied technologies based on DNA replication for application in gene therapy, cancer and wound healing. Key license and trade contracts: McGill University. Technological expertise: GT, D-D, DK Main products/instrumentation under R&D: Anti-replication molecules, preclinical; Artificial chromosome, preclinical; Origin of replication, preclinical; amplification of nucleic acid molecules; DNA replication for gene therapy. Sealed and granted patents: Amplification of nucleic acid molecules via circular replicons, 6,261,808, U.S.; other patents pending.

2420

REPLIGEN CORP.

Add: 41 Seyon Street Building #1, Suite 100 Waltham, MA 02453 Tel: (781) 250-0111 Fax: (781) 250-0115

Principal products/instrumentation: Fiblaferon (natural interferon beta); Fiblaferon-gel (topical IFN β formulation).

E-mail: [email protected]

Main products/instrumentation under R&D: IFN-β from CHO-cells, recombinant interferon beta, eucaryotic cell culture, cytokine-induced killer cells.

Research director: Jim Rusche

2419

REPLICON, INC.

Add: 910 — 7th Avenue SW Suite 800 Calgary, Alberta, T2P-3N8 Canada Tel: (403) 262-6519 Fax: (403) 233-8046 E-mail: [email protected] Web site: www.replicon.com President/CEO: Jean-Marc Juteau

Web site: www.repligen.com President/CEO: Walter C. Herlihy R&D expertise: R&D and manufacture of tools for drug discovery-biochemical libraries, high throughput screening assays; products for pharmaceutical manufacturing — protein A, immobilized protein A. R&D collaboration: Pfizer, Glaxo Wellcome in area of drug screening. Key license and trade contracts: Licensed to: Genetech (antibodies to CDIIa/CD18); Pharmacia Biotech (Protein A). Technological expertise: AB, F, BME, MAE, P/PS, PPAT, PC, RD, P/S, BA, C/TC, SY, DD Principal products/instrumentation: rProtein A™, IPA-300, IPA-400-immobilized

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Main products/instrumentation under R&D: Growth factor (bFGF, UEGF) antagonists- preclinical; tools for drug discovery.

antibodies using synthetic peptide analogues which mimic regions of difference in whole several proteins, development of custom immunoassays, antibody characterization, sale of stock products.

Sealed and granted patents: Composition of matter for recombinant Protein A.

Technological expertise: PA, P/S, H/CF, C/TC, PIS, SY

Protein A resins for production of monoclonal antibodies, ELISA kit for Protein A detection.

2421

REPROTECT, INC.

Add: 703 Stags Head Rd. Baltimore, MD 21286 Tel: (410) 337-8377 Fax: (410) 337-3838 E-mail: [email protected] Web site: www.reprotect.com President: Thomas R. Moench

Principal products/instrumentation: Monoclonal antibodies to hiNOS, IGF-l and 2, and EGF; polyclonal antibodies to PKC isoforms, NOS, dopamine receptors, growth factors, PTH, endothelin, LHRH, CGRP, ACTH and many others. RIA and IFA kits, Western immunoblotting reagents, muscarinic and opioid receptor antibodies. Main products/instrumentation under R&D: iNOS ELISA, Serotonin receptor antibodies. Subsidiary bodies: 4175 Lakeside Dr. #140, Richmond, CA 94806; others pending.

Research director: Kevin J. Whaley R&D expertise: Technology research for reproduction test, reproductive and sexual health; related applied drug development and production. Technological expertise: T, AB, RH Main products/instrumentation under R&D: Plantibodies, preclinical; Buffer Gel, Phase II; technology for reproduction test.

2423

RESEARCH DIAGNOSTICS, INC.

Add: 34 Junction Square Drive, Concord, MA 01742-3049 Tel: (978) 371-6446 Fax: (978) 371-2266 E-mail: [email protected] Web site: www.fitzgerald-fii.com

2422

RESEARCH & DIAGNOSTIC ANTIBODIES

President: Bret G. Wien Research director: Bret G. Wien

Add: 2645 W. Cheyenne Avenue North Las Vegas, NV 89032

R&D expertise: Research, manufacture and marketing of fine immunochemical products.

Tel: (702) 638-7800

Key sales market contracts: CLB reagents (Netherlands Red Cross), Cymbus Bioscience (U.K.), Kem-En-Tec (Denmark), SDT Inc. (Germany), Progen Biotech (Germany).

Fax: (702) 638-7801 E-mail: [email protected] Web site: www.rdabs.com President: Robert Webber, Ph.D.

Technological expertise: RD, P/S, C/TC, DD, DD

R&D expertise: Custom design, development and production of monoclonal and polyclonal

Principal products/instrumentation: PolyHRP (sensitive conjugate for blotting and

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immunoassays), extensive line of monoclonal antibodies.

Fax: (65) 6571-0868

Main products/instrumentation under R&D: Extended line of clustered monoclonal antisera for flow cytometry and histochemical staining; advanced purification media (MINI-LEAK™), agarose activated for less leaking of ligand, specialty biochemicals, fine immunochemical tracer.

Web site: www.ri.com.sg

2424

Pkwy.

R&D expertise: R&D technical support/marketing of bioreagents and instruments. Technological expertise: RD, C/TC, GA, BME Principal products/instrumentation: Biologicals, instruments, bioreagents, research kits.

2426

RESEARCH GENETICS, INC.

Add: 2130 Memorial Huntsville.AL 35801

E-mail: [email protected]

SW

RESEARCH ORGANICS, INC.

Add: 4353 E. 49th St. Cleveland, OH 44125 Tel: (216) 883-8025

Tel: (256) 533-4363

Fax: (216) 883-1576

Fax: (256) 536-9016

E-mail: [email protected]

E-mail: [email protected]

Web site: www.resorg.com

Web site: www.resgen.com

President: Marvin Sternfeld, Ph.D.

President: James R. Hudson

Research director: Dan Flowers

Research director: Robert Zahorchak, Ph.D.

R&D expertise: Development and production of highly purified biochemicals for molecular biology, cloning applications, diagnostic chemicals and cell/tissue culture.

Subsidiary of Invitrogen Corporation R&D expertise: Development of useful products to increase the rate of genetic discovery, research/development related novel biological. Technological expertise: PA, P/S, CS, P, PI, PPAT, PS, P/PS Principal products/instrumentation: Peptide instrumentation, custom DNA, custom peptides and mono-polyclonal antibodies, MapPairs microsatellite markers, microarray products, genomic libraries. Sealed and granted patents: MapPairs, microsatellite markers.

2425

RESEARCH INSTRUMENTS PTE., LTD.

Add: 26 Ayer Rajah Crescent #03-10 Singapore 139944 Tel: (65) 6571-0888

R&D collaboration: Dan Flowers Key sales market contracts: Rob Sternfeld Technological expertise: C/TC, P/S, PIS, CS, SY Principal products/instrumentation: Di-and Tri-peptides, Hepes, MOPSO, biological buffers, DTT, X-Gal, X-Gluc, Tris and Tris salts, MES, PIPES, SDS, IPTG, acrylamide; specialty biochemicals include chromogenic enzyme substrates Red-Gal®, Red-Gluc®, Red-Phos®; assay reagents, p-NBT, HDCBS, naphthol compounds; fluorescent labeling compounds Cy3™, Cy5 ™, TRITC, FITC, NDA. Subsidiary bodies: R&D laboratory production facility and bulk production expansion. Sealed and granted patents: Red-Gal®, RedGluc®, Red-Phos®, MOPSO, POPSO, TAPSO, HEPPSO, AMPSO, CAPSO.

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2427

RESEARCH PLUS, INC.

2429

759

RESEARCH TRIANGLE INSTITUTE

Add: P.O. Box 413, Barnegat, NJ 08005 Tel: (609) 698-5565 Fax: (609) 698-5566 E-mail: [email protected] Web site: www.researchplus.com President: George E. Korbelak, Jr. R&D expertise: R&D and synthesis/manufacture of peptide/steroids and miscellaneous compounds.

Add: 3040 Cornwallis Rd. P.O. Box 12194 Research Triangle Park, NC 27709 Tel: (919) 485-2666 E-mail: [email protected] Web site: www.rti.org President: F. Thomas Wooten, Ph.D. Research director: Alvin M. Cruze, Ph.D.

Technological expertise: SY, DD, PS, PIS, PPAT, P/PS, P

R&D expertise: Independent contract R&D of biopharmaceuticals/pharmaceuticals and biomedical laboratory equipment.

Principal products/instrumentation: Gastroenterology peptides.

Technological expertise: Q, P/S, BA, H/CF, C/TC, CH/S, SY, DD, D-D, BME

Main products/instrumentation under R&D: Peptide-ELISA, peptide screening, peptide synthesizer, steroid hormone.

Principal products/instrumentation: Biologicals, biopharmaceuticals, diagnostics, agriculture, pesticides, specialty chemicals, bioremediation, toxic waste processing technique, plastics, biomedical laboratory instruments, other contract R&D biopharmaceutical products.

2428

RESEARCH PRODUCTS INTERNATIONAL CORP.

Add: 410 N. Business Center Drive Mount Prospect, IL 60056-2190 Tel: (847) 635-7330

2430

RESEARCH TRIANGLE PHARMACEUTICALS, LTD

Fax: (847) 635-1177 Web site: www.rpicorp.com

Add: 4364 S. Alston Ave. Durham, NC 27713

President/CEO: Robert A. Chudy

Tel: (919) 361-2277

Research director: Dr. Ashok Chavan

Fax: (919) 361-2290

R&D expertise: Development, design and production of life science research products, encompassing liquid scintillation chemicals and vials, radiation safety, radioactive labelled compounds.

E-mail: [email protected]

Principal products/instrumentation: Biologicals, chemicals, instruments, reagents, life science research products, radioactive labeled compounds.

Subsidiary of Cato Holding Co.

Main products/instrumentation under R&D: Encompassing liquid scintillation chemicals.

R&D collaboration: CRADA and SBIR grants; various commercial relationships.

Web site: www.cato.com President/CEO: Gary Pace, Ph.D. Research director: Indu Parikh, Ph.D. R&D expertise: Biopharmaceutical product and professional technology development, novel products manufacture.

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Key sales market contracts: Sparta Pharmaceuticals foruse of MicroPartide™ technology with anticancer agents. Technological expertise: DD, D-D, P, PI, PIS, PPAT, PS, PS/AP Main products/instrumentation under R&D: MicroParticle™ drug delivery system, preclinical, U.S. and worldwide patents; Vasoactive intestinal peptide, vasoactive intestinal polypeptide, orphan drug for esophageal food impaction, Phase II; U.S. and European patents; Leupeptin, orphan drug grant awarded; animal pharmacology products.

brain imaging, RP801 Iodinated neuroreceptor, brain imaging.

2432

RESPONSE BIOMEDICAL CORP.

Add: 1781, 75th Avenue W. Vancouver, BC V6P 6P2 Canada Tel: (604) 456-6010 Fax: (604) 456-6066 E-mail: [email protected] Web site: www.responsebio.com President: William Raduak, B.Sc. Research director: Paul Harris, Ph.D.

2431

RESOLUTION PHARMACEUTICALS, INC.

Add: 6850 Goreway Dr. Mississauga, ON L4V 1P1 Canada Tel: (905) 677-0831 Fax: (905) 677-9595 Research director: Dr. Dennis Eshima R&D expertise: R&D of improved diagnostic imaging products for disease indications, currently focuses on the diagnosis of infection, inflammation and psychiatric disorders; develops drug products through internal research and aggressively seeks to in-license complementary products; develops strategic alliances with pharmaceutical and imaging companies to ensure effective marketing of its products worldwide. Scientific strengths include chelation technology, biochemical pharmacology, molecular modeling and medicinal chemistry. Joint ventures: Allelix Biopharmaceuticals Inc. and Nordion International Inc. Technological expertise: P, PI, PIS, PPAT, PS, P/PS Principal products/instrumentation: RP128 peptide/chelator, inflammation imaging technique, RP233 peptide/chelator, infection imaging technique; RP326 Iodinated neuroreceptor,

R&D expertise: Research of immunoassays, point-of-care diagnostics, related products development/manufacture. Technological expertise: PA, SMC Main products/instrumentation under R&D: Quantitative immunoassays, preclinical. Sealed and granted patents: “Quantitative Immunochromatographic Assays,” U.S. patent; other patents pending.

2433

RETSCH GMBH

Add: Rheinische Strasse 36 Haan 42781 Germany Tel: (49) 21-295-561 Fax: (49) 21-298-702 E-mail: [email protected] Web site: www.retsch.de President: Andre Verder, Jor Vok Research director: Mr. Meyer R&D expertise: R&D and production of professional equipment for sample preparation of solids. Technological expertise: BME, AMS Principal products/instrumentation: Analytical sieve shaker, AS200 control ag™; Mixer

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mill, MM 300™, Laboratory sample dividers, IT100 ™.

761

R&D collaboration: Various universities, research institutes and industrial partners. Key license and trade contracts: BASF Knoll, F. Hoffmann-La Roche and others.

2434

REVPRO, DIVISION OF PRO SCIENTIFIC, INC.

Add: P.O. Box 488 Monroe, CT 06468 Tel: (203) 268-5337 Fax: (203) 452-9753 E-mail: [email protected] Web site: www.hettich-zentrifugen.de President: Richard Yacko Research director: Richard Yacko R&D expertise: Development and manufacture/ marketing for centrifuge line. Technological expertise: BME Principal products/instrumentation: Hettich centrifuges, centrifugal separator, centrifugal ultrafiltration.

Technological expertise: RD, BA, P/S Principal products/instrumentation: Hansenula polymorpha expression system; recombinant hirudin, vaccines and immune modulators via Rhein Biotech Group. Main products/instrumentation under R&D: New expression systems, new and improved vaccines and immune modulators, polymorpha expression technology. Subsidiary bodies: Rhein Biotech N.V., The Netherlands (headquarters); Green Cross Vaccine Corp., South Korea; PC Gen S.A., Argentina; Vida Rhein, Portugal; Rhein Minapharm, Egypt; Wockhardt Rhein Biopharm Ltd., India. Sealed and granted patents: Hansenula polymorpha expression technology and others.

2436 2435

RHEIN BIOTECH GMBH

RHONE MERIEUX, INC.

Add: 115 Trans Tech Dr. Athens, GA 30601 Tel: (706) 548-9292

Add: Dynavax Europe, Eichsfelder Strasse 11,D-40595 Düsseldorf, Germany Tel: (49) 21-175-845 E-mail: [email protected] Web site: www.RheinBiotech.com President: Alexander Strausser, Ph.D. Research director: Ulrike Dahlems, Ph.D. Subsidiary of Rhein Biotech N.V., The Netherlands. R&D expertise: R&D, biotechnology medicine products and professional services: gene expression, development of production processes for recombinant proteins, production of preclinical samples, assistance in clinical development and registration. Joint ventures: Wockhardt Rhein Biopharm Ltd., India.

Fax: (706) 548-0608 President: Donald G. Hildebrand Research director: Mark Keister, Ph.D. R&D expertise: R&D and production of animal healthful biologicals/pharmaceuticals. Technological expertise: RD, F, P/S, BA, H/CF, C/TC, DD Principal products/instrumentation: RM Imrab ® rabies vaccine, RM Canine 6 canine vaccine; RM Potomavac® equine vaccine, RM Feline 4 feline vaccine.

2437

RIBI IMMUNOCHEM RESEARCH.INC.

Add: 553 Old Corvallis Rd. Hamilton, MT 59840-3131

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Tel: (406) 363-6214 Fax: (406) 363-6129 E-mail: [email protected]; [email protected] Web site: www.ribi.com President/CEO: Robert E. Ivy Research director: Charles Richardson, Ph.D. R&D expertise: Development, production and marketing of propriety immunostimulants/ adjuvants for human use prophylactically against infectious disease and therapeutically against cancer.

Main products/instrumentation under R&D: Therapeutics for diabetic retinopathy, HIV, corneal transplant, rejection, angiogenesis, cancer, AG products. Sealed and granted patents: U.S. patent number (and corresponding European-Japanese two patents): 4,987,071; 5,093,246; 5,037,746; 5,116,742.

2439

RICE LAKE WEIGHING SYSTEMS

R&D collaboration: SmithKline Beecham.

Add: 230 West Coleman St. Rice Lake, WI 54868

Technological expertise: D-D, P/S, H/CF, C/TC, DD, SY

Tel: (715) 234-9171

Principal products/instrumentation: Ribi Adjuvant System (RAS) for research use; mitogens, cells and cells components for research use. Main products/instrumentation under R&D: Melacine® melanoma theraccine, Phase III; MPL immunostimulant as an adjuvant, Phase I/II/III; MPL-C immunomodulator for ischemia/reperfusion injury, Phase I/II.

Fax: (715) 234-6967 E-mail: [email protected] Web site: www.ricelake.com President: Mark Johnson R&D expertise: Research of quality calibration and precision balance repair for laboratory and industrial use, related novel products development and manufacture. Technological expertise: BME, CH/S

2438

RIBOZYME PHARMACEUTICALS, INC.

Add: 2950 Wilderness Place Boulder, CO 80301

Principal products/instrumentation: Masstar calibration weights for laboratory and industrial use; IQ 9500 counting scale, digital indicators, explosive environment, precision balances.

Tel: (303) 449-6500 Fax: (303) 449-6995 President/CEO: Ralph E. Christoffersen

2440

RICERCA BIOSCIENCES, LLC

Research director: Alene A. Holzman

Add: 7528 Auburn Road, Concord, OH 44077

R&D expertise: R&D of pharmaceuticals products and functional genomics based on ribozyme technology.

Tel: (440) 357-3300

R&D collaboration: Parke-Davis, Chiron Corp., Dow Elanco, Pharmacia Biotech, Shering Ag (Berlex).

Fax: (440) 354-6276 E-mail: [email protected] Web site: www.ricerca.com President: James A. Scozzie, Ph.D.

Key license and trade contracts: Dow Elanco

Research director: Terry L. Foster

Technological expertise: Q, DD, D-D, TG, RD, HTDS

R&D expertise: Drug discovery, optimal drug candidates and drugs R&D services, on contract

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basis to develop and improve novel products, and support registration of products for worldwide regulatory compliance.

763

Zetalif Laser Induced Fluorescence Detector, Bischoff Prontosil HPLC columns. Subsidiary bodies: Laurel, MD.

Technological expertise: CC, PMC, P/S, SMC, SY Principal products/instrumentation: Contract manufacturing products, agricultural research; toxicology-animal metabolism; residue analysis; environmental fate; analytical services; synthetic chemistry; process development; information services, lead optimazation and drug candidate selection system, which includes: In vitro ADMET; In vivo ADMET; In cerebro ADMET. The Integrated Drug Development system includes: API Preparations; API Manufacture; Analytical Characterization; Process Development; Toxicology (early and late stage); Metabolism (early and late stage); Clinical Sample Analysis.

2442

RIESE ENTERPRISES, BIOSURE DIV.

Add: 12301 Loma Rica Dr., Unit G Grass Valley, CA 95945-9355 Tel: (916) 345-2267 Fax: (916) 273-5097 Web site: www.biosure.com CEO: Richard Riese R&D expertise: Research and design of biological controls, infectious waste handling systems, custom products/packaging and consulting, novel products manufacture. Technological expertise: E, P/S, C/TC

2441

RICHARD SCIENTIFIC, INC.

Add: 285 Bel Marin Keys Blvd. Novato, CA 94949 Tel: (415) 883-2888 Fax: (415) 382-1922

Principal products/instrumentation: BioSure® Sterilization Integrator, BioSure® Infectious Waste Handling Systems, BioSure® Flow Cytometry Controls, BioSure® Sheath Solutions. Main products/instrumentation under R&D: Plant Controls.

E-mail: [email protected] Web site: www.richardscientific.com President: Richard M. Devereaux Research director: Dr. Abdul Mazid R&D expertise: Design, manufacture/marketing of specialty liquid chromatography packings and instrumentation for analytical, preparative and process scale applications. Key sales market contracts: S.E.D.E.R.E., Hicrom Ltd., Sanwa Tsusho Ltd., Picometrics, Bischoff.

2443

RIGAKU

Add: 9009 New Trails Dr. The Woodlands, TX 77381-5209 Tel: (281) 362-2300 Fax: (281) 364-3628 E-mail: [email protected] Web site: www.rigaku.com President: Hikaru Shirnura

Technological expertise: P/S, COC, CB, HC, BME

Research director: Richard Ortega/John Martin

Principal products/instrumentation: SEDEX Evaporative Light Scattering Detector, Hichrom HPLC columns, UniFlow Degassers, pumps,

R&D expertise: Development and production of X-ray diffraction, X-ray fluorescence, and semiconductor equipment.

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Technological expertise: CB, COC, D-D, PMC, R

2445

RINTEKNO, OY.

Principal products/instrumentation: Contract research/clinical trial products, instrumentation, toxic waste processing method.

Add: Swing Life Science Center, P.O. Box 146 (Keilaranta 16 B), Visiting address: Keilaranta 14, FIN-02101 Espoo, Finland

Main products/instrumentation under R&D: X-ray diffraction, X-double diffraction line method, X-ray spectrum analysis, X-ray powder diffractometry.

Tel: (358) 9-104-5811 Fax: (358) 9-104-5898 E-mail: [email protected] Web site: www.rintekno.fi President: Olli Gerdt

2444

RIGEL PHARMACEUTICALS, INC.

R&D expertise: Engineering and design consultancy of biotechnological production plants. Technological expertise: BA, BS, PMC

Add: 1180 Veterans Boulevard, South San Francisco, CA 94080 Tel: (650) 624-1100 Fax: (650) 624-1101 E-mail: [email protected] Web site: www.rigel.com

Principal products/instrumentation: Tailored bioplants concepts; engineering and construction of bio/pharmaceutical production facilities. Main products/instrumentation under R&D: Biotechnology products plants.

President/CEO: James M. Gower Research director: Donald G. Payan, M.D., EVP and CSO

2446

RJ LEE GROUP, INC.

R&D expertise: Drug discovery, drug design, drug development and drug production.

Add: 350 Hochberg Rd. Monroeville, PA 15146

Technological expertise: DD, D-D, DDI, SMC, S, R, RD, BI, CC, G

Tel: (724) 325-1776

R&D collaboration: Janssen Pharmaceutica, N.V.; Pfizer, Inc.; Novartis Pharma, AG.

E-mail: [email protected]

Main products/instrumentation under R&D: Drug discovery programs in oncology, immunology; discovery modulators of leukocyte activation, drug design through disjunction.

President/CEO: Richard J. Lee, Ph.D.

Sealed and granted patents: Methods and compositions for screening using diphtheria toxin constructs. 7,060,433, U.S.; Modulators of leukocyte activation, Hck compositions and methods of use. 7,067,266, U.S.; other patents pending.

Fax: (724) 733-1799 Web site: www.rjlg.com Research director: Drew R. Van Orden R&D expertise: Development and manufacture of electron microscopy (TEM and SEM) and other analytical services to biotech, environmental and semiconductor industries. Technological expertise: BME, BTS Principal products/instrumentation: Contract R&D products, electron microscopy.

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Main products/instrumentation under R&D: Transmission electron microscopy, SEM, drug R&D plants.

2447

RK MANUFACTURING, INC.

Add: 1861 Little Orchard Street, San Jose, CA 95125 Tel: (408) 286-1861

765

Joint ventures: Primalco Ltd. and ABF Overseas Ltd. Technological expertise: E, F, Q, P/S, BA, GA, RD, ET Principal products/instrumentation: ECONASE®, ECOPULP®, ECOSTONE®, BIOTOUCH®, FINASE, Enzymes. Main products/instrumentation under R&D: Novel biotech drug, industrial enzymes.

Fax: (408) 280-1751 Web site: www.rkmfginc.com

2449

ROBBINS SCIENTIFIC

President: Peter Ritter Research director: Ralf Ritter

Add: 1250 Elko Drive Sunnyvale, CA 94089

R&D expertise: Applied development and production of imported liquid handling supplies for primary samples and reagents.

Tel: (408) 734-8500

Key sales market contracts: Fisher Scientific, Allegiance Healthcare, Mercedes Medical, Globe Scientific, Evergreen Scientific.

Fax: (408) 734-0300 E-mail: [email protected] President: Paul Rabbins Research director: Jim Stanchfield, Ph.D.

Technological expertise: C/TC, BME

Subsidiary of Sybron.

Principal products/instrumentation: Disposable dispenser tips, multiple channel pipettor, 1ml and 2ml 96-well plates and 12 segment cuvette.

R&D expertise: Development and manufacture of laboratory biomedical instruments and plastic disposables.

Main products/instrumentation under R&D: Disposable syringe, cell and tissue culture, reagents.

Technological expertise: Q, SMC, C/TC, GA, R, HTDS, COC, P/S, BME

Research director: Aria Mantyia

Principal products/instrumentation: Hybridization probe, reagents, human genome project, organ transplants/culture products, hybridization incubator, Hydra® 96 channel microdispenser, Cycle-Plate®-384, Strip-Ease® thin wall PCR tubes, Aeroshield® filter pipet tips, Cycle-Plate® PCRplates, FlexChem Organic Synthesis System, Hydra®-384 Microdispenser, EZ Switch™, FlexTip™ and SlimTip™ DNA Sequencing Gel Loaders, Hydra® HTS Workstation and Hydra®-AW Microdispensers, V-Groove™ Low Volume Reagent Reservoir; Tango Liquid Handling System.

R&D expertise: Biotechnology drug product development and manufacture/marketing industrial enzymes.

Main products/instrumentation under R&D: Disposable plasticware, laboratory drug screening devices.

2448

ROAL, OY.

Add: Tykkimäentie 15, 05200 Rajamäki, Finland Tel: (358) 9-290-420 E-mail: [email protected]. Web site: www.roal.fi President/CEO: Kari Edelmann

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ROBOCON, INC.

electrophoresis apparatus, glassware and associated consumables.

Add: 600 West German Town Pike Suite 400 Plymouth Meeting, PA19462-1046

Main products/instrumentation under R&D: Comb filter.

Tel: (888) 448-7762

Subsidiary bodies: Budapest, Hungary.

Fax: (888) 248-7762 E-mail: [email protected]

2452

ROCHE

Web site: www.robocon.com. President: Christian Pieler, Ph.D. Research director: Christian Pieler, Ph.D. Subsidiary of Robocon GmbH, Vienna Austria. R&D expertise: Design and production of automated laboratories for high throughput screening and microtiter plate handling, DNA and RNA Analysis.

Add: F. Hoffmann-La Roche AG, KonzernHauptsitz, Grenzacherstrasse 124, CH-4070 Basel, Schweiz Tel: (41) 61-688-1111 Fax: (41) 61-691-9391 E-mail: basel. [email protected] Web site: www.roche.ch President: Jim Powell, M.D.

Technological expertise: CH/S, R, HTDS

Research director: Gail Page

Principal products/instrumentation: Robolab.

R&D expertise: Clinical laboratory services of biotechnology medicines development.

Main products/instrumentation under R&D: Automated laboratories for high throughput biotech drug screening, microtiter plate handling technique, DNA and RNA sequence analysis. Subsidiary bodies: Robocon GmbH, Geiselbergstrasse 26-32, A-1110 Vienna, Austria.

2451

ROBOSYNTHON, INC.

Add: 703 Grandview Dr. S. San Francisco, CA 94080

Technological expertise: RD, GA, C/TC, PMC, CH/S Principal products/instrumentation: Diagnostics, clinical tests, mircera methoxy polyethylene glycol-epoetin beta) for the treatment of anemia associated with chronic renal failure, including patients on dialysis and patients not on dialysis, 2007. Main products/intrumentation under R&D: Tocilizumab (Actemna MRA, R-1569), PhaseIII, 2008; R744 CERA, Phase III, 2008.

Tel: (650) 244-0799 Fax: (650) 244-0795 E-mail: [email protected]

2453

ROCHE DIAGNOSTICS GMBH-BUSINESS UNIT: ROCHE MOLECULAR BIOCHEMICALS

President: Feren Darvas, Ph.D. R&D expertise: Production and marketing of instrumentation for comb.

Add: Sandnofer Str. 116 Mannheim D-68305 Germany

Technological expertise: BI, COC

Tel: (49) 621-759-8819

Principal products/instrumentation: MULTIREACTOR™, MAXI REACTOR™,

Fax: (49) 621-759-8609 E-mail: [email protected]

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Web site: www.roche.com

Tel: (610) 656-rock

President: Dr. Manfred Baier

Fax: (610) 367-7825

Research director: Thomas Metcalfe

E-mail: [email protected]

Subsidiary of Hoffmannn- La Roche AG.

Web site: www.rockland-inc.com

R&D expertise: R&D and production of molecular diagnostics, biotechnology drug, molecular systems based on PCR, laboratory systems, bioprocess engineering.

President: Joy Cappel

Technological expertise: CC, E, F, PA, AB, BA, COC, C/TC, HTDS, PMC, P/S, LP, RD Principal products/instrumentation: Customized industrial enzymes; biocatalysts; active Ingredients, enzymes, specialty chemicals, monoclonal antibodies, molecular diagnostics, molecular systems based on PCR, other biological drug.

2454

ROCHE MOLECULAR BIOCHEMICALS

Add: 9115 Hague Road Indianapolis, IN 46250 Tel: (800) 262-5074 Fax: (800) 428-2883 E-mail: [email protected] Web site: www.biochem.roche.com R&D expertise: Development and manufacture of biochemicals. Technological expertise: E, PA, CB, C/TC, GA, P/S, RD, G, R Principal products/instrumentation: LightCycler Sytem™, FastStart Taq DNA Polymerase™, Magnapure System™, RTS 500 System™; reagents, specialty biochemicals.

2455

ROCKLAND IMMUNOCHEMICALS, INC.

Add: P.O. Box 326 Gilbertsville, PA 19525

767

Research director: Carl Ascali R&D expertise: Cell and tissue culture research, Human Genome Project and high throughput screening drugs, development in the fields of immunology, molecular biology and microbiology, the scale-up production and purification of a wide range of antibodies and antigens through monoclonal and polyclonal antibody techniques as well as baclovirus expression. R&D collaboration: Sterling Drug, DuPont/Merck, Ciba Geigy, Eli Lilly, antibody development. Key sales market contracts: VWR Scientific Products, KEBO Labs, Biotrend GmbH, TEBU. Technological expertise: E, P/S, C/TC, SY, PMC, AB Principal products/instrumentation: Primary, secondary and custom antibodies, purifies proteins and buffers. Primary antibodies include apolipoproteins, cell cycle, cytokines, enzymes, extracellular matrix and transcription factors. Secondary antibodies include against IgG, IgA, IgM, fc and F(ab)2 and conjugated to alkaline phosphate, Cy dyes, biotin, FITC, magnetic particles, peroxidase, phyceorythrin, rhodamine, and texas red, streptavidin, avidin. Main products/instrumentation under R&D: Transcription antibodies/neuroscience reagents, cell cycle antibodies, DNA based immunizations, patented portfolio drugs. Sealed and granted patents: Rockland Immunochemicals patent portfolio drugs includes a broad range of unique antigen delivery systems.

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ROCKLAND TECHNOLOGIES, INC.

Add: De Pinckart 54 NL-5674 CC Nuenen, The Netherlands Tel: (31) 40-631-234

Principal products/instrumentation: Contract research/clinical trial products, in vitro toxicology testing method, state-of-the-art analysis of biotechnology products, degradants, and metabolites, HPLC/MS/MS. Main products/instrumentation under R&D: Novel biotech drug.

Fax: (31) 40-840-582 E-mail: [email protected] Web site: www.rti.zorbax.com President: Dr. Joe De Stefano

2458

RONE BIOTECHNOLOGY CONSULTING

Research director: Dr. J. J. Kirkland

Add: P.O. Box 578 Warnerville, IL 60555

R&D expertise: R&D and manufacture of ZORBAX ® HPLC columns.

Tel: (630) 638-2585

Key license and trade contracts: Rockland Technologies, Inc; DuPont Co.

Web site: www. mcs. net/~rone

Technological expertise: CC, SMC, PIS, P/S, HC Principal products/instrumentation: ZORBAX® HPLC Columns, ZORBAX Stable Bond® HPLC Columns. Main products/instrumentation under R&D: HPLC Columns, HPLC-grade solvent, HPLCgrade reagents.

2457

ROCKY MOUNTAIN INSTRUMENTAL LABORATORIES, INC.

Add: 108 Coronado Ct. Ft. Collins, CO 80525 Tel: (970) 266-8108 Fax: (303) 530-1169 E-mail: [email protected] Web site: www.rockylab.com President/CEO: Robert K. Lantz, Ph.D. Research director: Patricia L. Sulik, Ph.D. R&D expertise: Innovative contract analysis of biotechnology drug products. Technological expertise: CC, Q, SMC, P/S

E-mail: [email protected] President: Rebecca Rone, Ph.D. R&D expertise: Information technology methods (research informatics) applied to chemistry and biology; structure-based drug design and molecular modeling, including force field development; computer algorithm and software modeling, including force field development; computer algorithm and software development for commercial use and strategic partnerships; scientific software evaluation and validation for acquisitions or mergers; project management for software development and technology transfer, competitive analysis of information technology for business or financial strategies; preparation of written material for scientific journals, grant proposals, and business reports; competitive analysis of research informatics in computational biology and chemistry. Technological expertise: BTC, BTS, BI, CH/S, G, D-D, HTDS. Principal products/instrumentation: Software in molecular modeling for the interaction of drug candidates with target proteins and protein-protein interactions, proprietary IT software in bioinformatics/genomics to major pharmaceutical companies, programming

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probabilistic evaluation of single nucleotide polymorphisms (SNPs), research on core molecules and pharmacophores for combinatorial chemistry library design and high throughput screening (HTS), proteomics-implemented methods for target validation. Main products/instrumentation under R&D: Software for commercial use, structure-based drug molecular modeling.

2459

ROUSSEL UCLAF

Add: 102 Route De Noisy Romainville Cedex 93235 France Tel: (33) 149-914-252 Fax: (33) 149-913-119

769

Subsidiary of Roper Industries R&D expertise: R&D and manufacture of cooled CCD cameras and other instrumentation for scientific applications. Technological expertise: BME Principal products/instrumentation: contract manufacturing products, Photometries CoolsNAP™, Photometrics Quantix™, Photometrics SenSys™, Princeton Instruments Micromax. Main products/instrumentation under R&D: Photometric titration methods.

2461

ROPER SCIENTIFIC, INC.

President: Dr. E. Sakiz

Add: 3660 Quakerbridge Rd. Trenton, NT 08619

Research director: MJ. Raynaud

Tel: (609) 587-9797

Subsidiary of Hoechst AG.

Fax: (609) 587-1970

R&D expertise: R&D and production of pharmaceuticals, agroveterinary, pharmaceutical bulks.

E-mail: [email protected]

R&D collaboration: INSERM, CNRS, Transgene, Vertex, Ariad.

R&D expertise: Design, development and manufacture of digital imaging systems.

Technological expertise: F, Q, E, RD, P/S, BA, H/CF, C/TC, D-D

Technological expertise: DD, RD, G, CH/S, C/TC, GT, HTDS, SMC

Principal products/instrumentation: Claforan®, Rulid®, Rythmodan®, Surgam®. Subsidiary bodies: Romainville, France; Neuville Sur Saone, France; Vertolaye, France; Swindon, Wiltshire, U.K.

2460

ROPER SCIENTIFIC, PHOTOMETRICS

President: Daniel J. Pisano Research director: Mark Christenson

Principal products/instrumentation: Digital camera systems, X-ray imaging systems, digital imaging microscope and electron microscope imaging systems, spectroscopy systems, digital imaging systems.

2462

ROSE SCIENTIFIC, LTD.

Add: 3440 E Britannia Dr Tuscon, AZ 85706

Add: 4027-97 St. Edmonton, Alberta T6E 5Y5 Canada

Tel: (520) 889-9933

Tel: (800) 661-9288

Fax: (520) 573-1944

Fax: (800) 570-6067

Web site: www.photomet.com

E-mail: [email protected]

President: Daniel J. Pisano, Jr.

Web site: www.rosesci.com

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President: Ahamed Hussain Research director: Roman Swedia R&D expertise: R&D and manufacture of laboratory biomedical equipment, all types of shakers, mixers, rotators, and custom chemical synthesis. Joint ventures: Chemica Alta Ltd. Key sales market contracts: Heidolph Instruments, TeioTech, Fine Par, Socotex. Technological expertise: F, CB, SMC, SY, BME, CS Principal products/instrumentation: A series of fluorogenic enzyme substrates, shakers and incubated shakers, contract manufacturing products. Main products/instrumentation under R&D: Other carbohydrate reagents, shaking screen, mixing agitator.

2463

ROSETTA INPHARMATLCS LLC

Add: 401 Terry Avenue N, Seattle, WA 98109 Tel: (206) 802-7000 Web site: www.rii.com President/CEO: Bruce A. Cohen Research director: Matthew Ashby, Ph.D. R&D expertise: R&D of drug discovery technology, proprietary assay systems and databases that facilitate the rapid development of biopharmaceuticals and agricultural chemicals, Genome Reporter Matrix™ (GRM). R&D collaboration: ArQule, Inc. Key license and trade contracts: American Cyanamid Corp. ( a subsidiary of American Home Products Corp.), Bristol-Myers Squibb Co., DuPont Agricultural Enterprise (a division of DuPont), Eli Lilly & Co., Novartis Crop Protection, Inc. Technological expertise: R, Q, BI, C/TC, CH/S, PG, RD

Principal products/instrumentation: Genome Reporter Matrix™ — a series of novel tools that provide practical analysis of early stage chemicals by interpreting their effects across entire genomes; technology used to discover novel targets and gene regulatory mechanisms. Main products/instrumentation under R&D: Target gene discoveries, research and development, target validation; opportunity to develop anti-cancer therapeutics; opportunity to develop cholesterol reduction agents, gene expression profiles, cell expression profiles. Sealed and granted patents: Under the terms of its agreement with the University of California, Acacia has exclusive rights to use and sublicense U.S. patent nos. 5,569,588 and 5,777,888; Method and system for analyzing biological response signal data. 6,453,241, U.S.; Methods of determining protein activity levels using gene expression profiles. 6,324,479, U.S.; Statistical combining of cell expression profiles. 6,351,712, U.S.; Methods of ranking oligonucleotides for specificity using wash dissociation histories. 6,673,536, U.S.; Methods for generating differential profiles by combining data obtained in separate measurements. 6,691,042, U.S.; Gene discovery using microarrays. 6,713,257, U.S.; Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays. 7,013,221, U.S.; computer systems and methods for associating genes with traits using cross species data. 20070166707, U.S.

2464

ROSGEN, LTD.

Add: Roslin Institute Biotechnology Park Roslin, Midlothian, Scotland EM25 9PS U.K. Tel: (44) 131-527-0300 Fax: (44) 131-527-0310 E-mail: [email protected] CEO: Dr. Pete Kitchin

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Research director: Dr. David Ashworth R&D expertise: R&D of genotyping for identity testing and parentage verification, DNA sequencing, genetic disease predisposition testing, related genotyping products manufacture. R&D collaboration: Roslin Institute, Roslin, Midlothian.

771

Sealed and granted patents: WO 09831793A2 (Growth Factor), WO 99/55350 (AntiThrombotic Agent), WO 99/11785 (Display Technology); WO 9913090 (Cell Factor).

2466

R.P.R. GENCELL

Key sales market contracts: Scottish Agricultural College, Bio Estate, Edinburgh.

Add: 3825 Bay Center PL Hayward, CA 94545

Key license and trade contracts: PE AgGen, Roche.

Fax: (510) 887-1680

Technological expertise: Q, BI, CH/S, PG, P/S

Research director: Francois Meyer

Principal products/instrumentation: Genotyping for use in cattle, genotyping for use in dogs, meat quality assurance tracking.

R&D expertise: Research design of gene therapy for genetic disease/immune diseases; biological drugs development and production.

Main products/instrumentation under R&D: Genetic disease predisposition testing method. Genotyping for identity and parental verification.

Joint ventures: Rhone-Poulenc Rorer, to develop and collaborate on research, marketing.

2465

ROWETT RESEARCH SERVICES, LTD.

Add: Greenbank Road Bucksburn Aberdeen AB21 9SB U.K.

Tel: (510) 784-1070 CEO: Thierry Soursac, M.D., Ph.D., MBA

Technological expertise: GT, RD, P/S, C/TC Principal products/instrumentation: Gene therapy products, contract R&D products, genetically engineered antibodies, genetically engineered drug.

2467

R. SHADEL, INC.

Tel: (44) 122-471-2751 E-mail: [email protected]

Add: 1684 Hudson Ave, San Francisco, CA 94124

Web site: www.rowett.ac.uk

Tel: (415) 648-6806

CEO: Alan Rowe

Fax: (415) 648-2139

Subsidiary of Rowett Research Institute.

E-mail: [email protected]

R&D expertise: Development of nutrient drug, related nutrient products manufacture.

Web site: www.shadel.com

Key license and trade contracts: Metra Biosystems Inc. (Collagen Crosslinks); Alizyme PLC (Growth Factor).

R&D expertise: R&D and production of horizontal gel rigs and radiation shield.

Technological expertise: E, F, PA, C/TC, P, PI, PIS, PPAT, PS, PS/AP, P/PS

Principal products/instrumentation: Wedge™ horizontal gel rigs (four sizes), Exposure Enclosure radiation shield.

Fax: (44) 122-471-5349

Main products/instrumentation under R&D: Anti-platelet nutraceutical, preclinical; Nutrition, Peptide Display Technology, Platform technology, various cytokines, nutritional supplements.

President: Robert Shadel

Technological expertise: P, C/TC, RD, P/S

Main products/instrumentation under R&D: Vertical and horizontal electrophoresis lab accessories — shields, racks.

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RULAC TECHNOLOGIES PVT, LTD.

Add: 106, Bharat Ind. Estate, Opp. Asian Paint Ltd., L.B.S. Road, Bhandup (W) Mumbai 400 078, India Tel: (91) 22-6796-9060 Fax: (91) 22-6796-9060 E-mail: [email protected] Web site: www.rulac.com R&D expertise: Development and manufacture of biomedical laboratory equipment and labwares. Technological expertise: BME Key sales market contracts: Through local distributors citywise in all India markets. Principal products/instrumentation: Energy Conservation for A/C System, Energy Conservation for Cooling System, Energy Conservation for Cooling Tower, Energy Conservation for Motor. Main products/instrumentation under R&D: Laboratory reagents, laboratory data-information management systems.

2469

SAATEN-UNION

testing; Molecular markers; Genetic typing and transformation. R&D collaboration: Institute of Plant Genetics and Crop Plant Research Gatersleben; Agrogene France; Giessen University; University of Bonn; Gottingen University. Key license and trade contracts: IPK Gatersleben Germany. Technological expertise: T, AF, BI, C/TC, GA, G, R, S Principal products/instrumentation: Agriculture, contract manufacturing products, contract research plant breeders, DH-production technique in barley, DH-production technique in wheat, DH-production technique in rapeseed. Main products/instrumentation under R&D: High throughput DNA (plant) extraction system, partner search; High throughput plant tissue handling system, partner search; doubled haploid lines in cereals and rapeseed. Sealed and granted patents: CRUSH EXPRESS™.

2470

S. A. CHEMICALS

Add: Trading Div. 4/33, Malad Co-op. Soc. Ltd. Poddar Park, Malad (E.) Mumbai, Maharashtra, 400 097 India Tel: (91) 22-876-4700

Add: Eisenstr. 12, D-30916, Isernhagen HB, Germany Tel: (49) 511-726-660

Fax: (91) 22-883-5347 E-mail: [email protected] Web site: www.sachemicals.com

Fax: (49) 511-726-66110

CEO: Anil Jain

E-mail: [email protected]

Research director: Dr. Ashlesha Parchw

Web site: www.saaten-union.de

R&D expertise: Development and marketing of pharma and food ingredients.

CEO: Dr. Hans-Friedrich Finck/Dr. Martin Frauen Subsidiary of Saaten-Union GmbH. R&D expertise: Development and production of doubled haploid lines in cereals and rapeseed; Research for plant breeders; Resistance

Joint ventures: Manufacturing of Ampoules with Bombay Ampoules Pvt. Ltd Technological expertise: C/TC, AB Principal products/instrumentation: Cyclodextrin, Lycopene; Carnitine.

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Main products/instrumentation under R&D: Food supplements, food effective ingredients.

2471

SALIVA DIAGNOSTIC SYSTEMS, INC.

Add: 11719 NE 95th St. Vancouver, WA 98682

773

R&D collaboration: HyCult biotechnology b.v. — Uden, The Netherlands. Technological expertise: P/S, C/TC, MAE, PA Principal products/instrumentation: Monosan- monoclonal and polyclonal antibodies, cytokine kits, TNF kits, reagents.

Tel: (360) 696-4800 Fax: (360) 254-7942

2473

SANETECH, INC.

President/CEO: Kenneth McLachlan R&D expertise: R&D of in vitro immunoassays (rapid) and production of biomedical specimen collectors.

Add: 460 Mifltown Rd. Bridgewater, NJ 08807-2581 Tel: (201) 579-1313

Technological expertise: BME

Fax: (201) 579-3908.

Principal products/instrumentation: OmniSAL, Omni-Swab, Saliva Sampler, Sero Strip HIV, Hema Strip HIV, Saliva Strip HIV, Stat Simple pylori.

President/CEO: Bob DuPont Sr.

Main products/instrumentation under R&D: Rapid serum tests for hepatitis A and tuberculosis; in vitro rapid immunoassays. Sealed and granted patents: On certain aspects of Omni-SAL, a saliva collection device, in the U.S.A. and eight other countries. Patent pending on Hema Strip HIV in the U.S.

2472

SANBIO B.V.

Add: Frontstraat 2c — 5405 PB Uden, The Netherlands Tel: (31) 413-251-115

Subsidiary of Nalge Co. R&D expertise: Development and manufacture of drug delivery devices, including sanitary non-metallic tubing, medical grade silicone tubing, sanitary transfer hoses. Technological expertise: DD Principal products/instrumentation: Contract manufacturing products, in vitro toxicology testing, organ transplants/culture, drug delivery devices, S.I.B. (Smooth Inner Bore) technology, silastic platinum cured silicone tubing, teflon lined hoses, S.I.B. crevice free welding. Sealed and granted patents: S.I.B., Sani-Lock

2474

SANGAMO BIOSCIENCES, INC.

Fax: (31) 413-266-605 E-mail: [email protected] Web site: www.sanbio.nl President: W. H. de Niet Research director: Dr. W. A. Buurman R&D expertise: Development and production of biotechnology medicine products. Joint ventures: HyCult biotechnology b.v. — Uden, The Netherlands.

Add: Pt. Richmond Tech Center 501 Canal Blvd., Ste. A100 Richmond, CA 94804 Tel: (510) 970-6000 Fax: (510) 236-8951 E-mail: [email protected] Web site: www.sangamo.com President/CEO: Edward Lanphier Research director: Alan Wolffe, Ph.D.

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R&D expertise: Drug discovery research, development of novel transcription factors for gene regulation. Pharmaceutical R&D technology enables the engineering of a specific class of transcription factors known as zinc finger DNA binding proteins, or ZFP’s (zinc finger proteins). Joint ventures: 19 pharma/biotech companies using ZFPs for drug discovery. In addition, Sangamo has a strategic alliance with Edwards Lifesciences Corporation to develop novel therapeutics for cardiovascular disease.

in cells using zinc finger proteins. 6,607,882, U.S..; Regulation of endogenous gene expression in cells using zinc finger proteins. 6,824,978, U.S.; Modulation of gene expression using localization domains. 6,919,204, U.S.; Gene identification. 6,780,590, U.S.; Gene switches. 6,706,470, U.S. Targeted modification of chromatin structure. 7,001,768, U.S.; regulated gene expression in plants. 20080070306, U.S.

2475

SANGSTAT MEDICAL CORP.

Key license and trade contracts: Johns Hopkins University, The Scripps Research Institute, Massachusetts Institute Of Technology, Medical Research Council.

Add: 6300 Dumbarton Circle Fremont, CA 94555

Technological expertise: Q, TE, T, BI, CH/S, GA, GT, RD, COC

Fax: (510) 789-4400

Principal products/instrumentation: Universal Genetools for drug discovery/validation, zinc finger DNA binding proteins, human cell lines, primary cells. Main products/instrumentation under R&D: Novel transcription factors for gene regulation used to treat cardiovascular diseases, cancer, infectious diseases, ZFP-Therapeutics for cardiovascular disease, infectious disease and cancer, zinc finger proteins for the identification of gene function, endogenous gene expression in cells. Sealed and granted patents: 5,789,538, U.S., Zinc finger proteins with high affinity, new DNA binding specifications; 6,007,988, U.S., relating to binding proteins for recognition of DNA; 6,013,453, U.S., binding proteins for recognition of DNA; Methods of using randomized libraries of zinc finger proteins for the identification of gene function. 6,503,717, U.S.; Modulation of endogenous gene expression in cells. 6,933,113, U.S.; Regulation of endogenous gene expression in cells using zinc finger proteins. 7,013,219, U.S.; Functional genomics using zinc finger proteins. 6,777,185, U.S.; Regulation of endogenous gene expression

Tel: (510) 789-4300 President/CEO: Jean-Jacques Bienaime Research director: Roland Buelow, Ph.D. R&D expertise: R&D and production of therapeutics and monitoring products for organ transplantation. R&D collaboration: Co-promotion, distribution, and research with Abbott for cyclosporin. Key sales market contracts: Co-promotion, distribution, and research with Abbott for cyclosporin. Key license and trade contracts: Distribution agreements with AMGEN for SANG-35, Cyclosporine in Australia, New Zealand, and Greater China; Co-promotion, distribution, and research with ABBOTT for cyclosporine. Technological expertise: CH/S, SY, D-D, RD, P/S, C/CF, C/TC Principal products/instrumentation: Organ transplants/culture products, Thymoglobulin® (rabbit thymocyte globulin), polyclonal antibody, prevention of kidney transplant rejection; SangCya™ oral solution. Main products/instrumentation under R&D: SangCya™ capsules; RDP-58 TNT inhibitor, monitoring devices for organ transplantation.

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2476

SANGUINE CORP.

Add: 101 East Green St., Suite 6 Pasadena, CA 91105

2478

775

SANYO E&E EUROPE BV, BIOMEDICAL DIVISION

Tel: (801) 746-3570

Add: 9 The Office Village North Road Loughborough Leicestershire LE11 1QJ, U.K.

Fax: (801) 532-1765

Tel: (44) 150-926-5265

E-mail: [email protected]

Fax: (44) 150-926-9770

Web site: www.sanguine-corp.com

E-mail: [email protected]

President/CEO: Thomas G Drees, MBA, Ph.D. R&D expertise: Research of synthetic blood, related blood products or blood plasma substitute manufacture. R&D collaboration: Battelle Memorial Institute Key sales market contracts: Biologix. Technological expertise: BS Main products/instrumentation under R&D: Synthetic blood, blood plasma substitute, blood preparation, blood substitute.

2477

SANVERTECH NV

Add: Alexander Franckstraat 196, B-2530 Boechout, Belgium Tel: (32) 3-454-0066 Fax: (32) 3-451-8888 E-mail: [email protected]

Web site: www.sanyo-biomedical.co.uk President: Y. Fujimoto Research director: Graham Beale Subsidiary of Sanyo Electric. R&D expertise: Design, development, manufacturing and marketing of laboratory equipment for biomedical research. Key license and trade contracts: Perkin Elmer for the supply of licensed PCR thermal cyclers. Technological expertise: C/TC, PMC, P/S, BME Principal products/instrumentation: MSE Centrifuges; Gallenkamp temperature control equipment; Fitotron plant growth cabinets; Fistreem water purification products; Sanyo freezers, PCR thermal cyclers.

2479

SAPPHIRE BIOSCIENCE PTY, LTD.

Web site: www.tebu-bio.com

Add: Suite 1, 134 Redfern Street, Redfern NSW 2016, Australia

President: Donald van Dijle

Tel: (612) 9698-2022

Subsidiary of TEBU SA.

Fax: (612) 9698-1022

R&D expertise: Manufacture and marketing of laboratory reagents for biomedical research.

Web site: www.sapphirebioscience.com

Technological expertise: C/TC, BTS

Key sales market contracts: Cayman Chemical, Biomol Research, YMC Inc., List Biologicals, Oxis International, Seikagaku Corporation and Genetex.

Principal products/instrumentation: In vitro toxicology testing products, organ transplants/culture, laboratory reagents.

R&D expertise: Manufacture and marketing of life science research products.

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Technological expertise: PA, CB, COC, GA Principal products/instrumentation: Biologicals, specialty chemicals, clinical tests, vaccines, reagents, pharmaceuticals, life scientific products, biosensor.

2481

SARTORIUS CORP.

Add: 131 Heartland Blvd. Edgewood, NY 11717 Tel: (800) 645-3108 E-mail: [email protected]

2480

SARAWAK MEDICHEM PHARMACEUTICALS, INC.

Add: 1440 Davey Road, Woodridge, IL 60517 Tel: (630) 739-9841 Fax: (630) 739-6754 E-mail: [email protected] President: Michael T. Flavin, Ph.D. Research director: Ze-Qi Xu, Ph.D. Subsidiary of MCR Holdings and Government of Sarawak, Malaysia. R&D expertise: Antiviral, anticancer and antiinflammatory drug design/development, novel products manufacture. Joint ventures: Sarawak MediChem Pharmaceuticals — a joint venture between MCR Holdings and the state government of Sarawak, Malaysia. Key license and trade contracts: Licensed calanolide and related antiviral compounds from the National Cancer Institute (NCI). Technological expertise: CC, COC, CH/S, DD, D-D, PMC, P/S, SMC, SY

Web site: www.sartorius.com President: Silvano Ghirardi R&D expertise: Bioprocess engineering research, development, manufacture and sales of separations products for the biotech industry. Technological expertise: F, P,/S, RD, IP, BA, C/TC, PMC, P/S Principal products/instrumentation: Minisart™ syringe filters; Sartobran™ sterilizing filters; Sartocon™ cross-flow filtration; Membrane Adsorbers™ membrane based chromatography systems; Sartocheck™ integrity test systems; Biologicals, antibiotics, vaccines, monoclonal antibodies, enzymes, single cell proteins, DNA removal, endotoxin removal.

2482

SASKATCHEWAN RESEARCH COUNCIL

Add: 125-15 Innovation Boulevard, Saskatoon, SK S7N 2X8, Canada Tel: (306) 933-5400

Main products/instrumentation under R&D: Biologicals, contract research/clinical trials products, natural products, (+)− Calanolide A for HIV infections, Phase I/II clinical trials; (−) Calanolide B for HIV infections, preclinical; Calanolide ketones, preclinical.

Fax: (306) 933-7446

Sealed and granted patents: Method for preparation of (+)calanolide A; Calanolide and related antiviral compounds, compositions and use, other patents pending.

R&D expertise: Contract research of biotechnology medicine products and development service.

E-mail: [email protected] Web site: www.src.sk.ca President/CEO: James Hutchinson Research director: Dr. Krystyna Sosulski

Joint ventures: TecMark.

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R&D collaboration: University of Saskatchewan, Agriculture and AgriFood Canada, University of Regina. Key sales market contracts: TecMark. Technological expertise: E, F, T, BA, CH/S, PMC, P/S Main products/instrumentation under R&D: Contract research/clinical trial products, natural products, fermentation products for agriculture (inoculants, biocontrol agents, vaccines, enzymes); DNA research services.

2483

SASKATCHEWAN WHEAT POOL RESEARCH & DEVELOPMENT

Add: 201-407 Downey Road, Saskatoon, SK S7N 4L8, Canada Tel: (306) 668-6630 Fax: (306) 668-5564 E-mail: [email protected] Web site: www.swp.com President: L. Larson Research director: R. E. Morgan R&D expertise: Development and manufacture of agriculture/agrifood. R&D collaboration: University of Manitoba; University of Saskatoon, Calgene, NRC-PBI, Perf. Plants.

777

Fax: (714) 526-7400 President: Howard J. Sloane R&D expertise: Development and manufacture of computer-based training programs for drug research. Technological expertise: CH/S, BTS Principal products/instrumentation: Audiovisual and computer-based training programs in analytical chemistry and lab safety. Main products/instrumentation under R&D: Computer-aided drug design system.

2485

SAVANT INSTRUMENTS/ E-C APPARATUS

Add: 100 Colin Dr. Holbrook, NY 11741-4306 Tel: (516) 244-2929 Fax: (516) 244-0606 E-mail: [email protected] Subsidiary of ThermoQuest. R&D expertise: Laboratory equipments, development and manufacture. Technological expertise: CC, Q, AB, COC, GA, G, HTDS, P/S, PIS, RD, SMC, SY Principal products/instrumentation: Concentration products, electrophoresis products (electrophoresis apparatus, electrophoresisgrade reagent, etc., SpeedVac®.

Technological expertise: T, C/TC, RD Principal products/instrumentation: Ultrabred crop, varieties: canola, wheat, barley, peas, lentils. Main products/instrumentation under R&D: Various canola varieties.

2486

SAVYON DIAGNOSTICS, LTD.

Add: Kiryat Minrav 3 Habosem Street Ashdod 77610 Israel Tel: (972) 8-856-2920 Fax: (972) 8-852-3176

2484

SAVANT AUDIOVISOALS, INC.

E-mail: [email protected]

Add: 801 E. Chapman Ave. #101, P.O. Box 3670, Fullerton, CA 92834

Web site: www.savyondiagnostics.com

Tel: (714) 870-7880

Research director: Dr. Bella Ohana

President: Mr. Yakov Ofer

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Subsidiary of Healthcare Technologies, Ltd. R&D expertise: Development and production of diagnostic, STD kits, UTI and viral diagnostics. R&D collaboration: Meiji Milk Products and Toshin Chemical Co., rapid tests for Chlamydia. Direct detection of Chlamydia in urine (Iris). Key sales market contracts: Distribution agreements in Europe, U.S.A., and Asia. Technological expertise: C/TC, BS, BME Principal products/instrumentation: Contract manufacturing products, IPAzyme Chlamydia IgG/IgA and IgM; IPAzyme EBV7VCA IgG/IgA and IgM; SeroELISA Chlamydia IgA, IgG, IgM; Uriscreen Rapid UTI screen; Diaslide urine culture device; MP Test-reverse ELBA kit; SeroFIA Chlamydia IgG, IgA, IgM kits; SeroCT-Chlamydia Trachomatis specific ELISA IgG and IgA kits; Rapid Serochlamydia IgA and IgG kits; HIVSAV kit; SeroELISA Chlamydia pneumoniae IgG/IgA/IgM kits; HerpELISA; Piezoelectric Immunosensors, Amperometric Biosensors, development; Nucleic acid detection, development; SeroMP IgG/IgA/IgM. Main products/instrumentation under R&D: STD kits, UTI diagnostics, biosensors. Sealed and granted patents: Biosensors, diaslide, uriscreen.

2487

SBH SCIENCES, INC.

Add: SBH Sciences, 4 Strathmore Road, Natick, MA 01760

R&D expertise: Design, development and manufacture of biological reagents and therapeutics, etc. Technological expertise: TE, HDS, RD, P/S, BA, C/TC, H/CF Principal products/instrumentation: Contract research/clinical trial products, h-IL-12, m-IL-12, h-TGF-beta 1, h-TGF-beta 3, h-HGF; bioassays services. Main products/instrumentation under R&D: Cell culture media; bioassays, HGH.

2488

SCANALYTICS

Add: 15010 Broschart Road, Rockville, MD 20850 Tel: (301) 340-7320 Fax: (301) 340-9775 E-mail: [email protected] Web site: www.scanalytics.com President: Dr. Michael Mort Research director: Leonard Hook, Ph.D. Subsidiary of CSP, Inc. R&D expertise: Development and production of bioresearch imaging software and hardware. Technological expertise: CH/S, BTS, FL Principal products/instrumentation: CELLscan Fluorescence Microscopy, DNAscan Automatic Sequencing, RFLPscan I-D Gel Analysis, AMBIS Radioisotopic Imager, ONE-D scan/ZERO-D scan Blot Analysis, IP Lab Spectrum, IPLab Gel software. Main products/instrumentation under R&D: Imaging densitometer, image sensor.

Tel: (508) 650-6218 Fax: (508) 650-6220 E-mail: [email protected] Web site: www.sbhsciences.com Research director: Dr. Raphael Nir

2489

SCANALYTICS, INC.

Add: 8550 Lee Highway Suite 400 Fairfax, VA 22031-1515

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Tel: (703) 208-2230 Fax: (703) 208-1960 E-mail: [email protected] Web site: www.scanalytics.com President: Fernado Delaville Subsidiary of CSP, Inc. R&D expertise: Research and production of scientific imaging systems and related software. Technological expertise: CH/S, BTS Principal products/instrumentation: IPLab Spectrum; IPLab Gel; Image Explorer, MultiProbe, Ratio, 3D, EPR, CellScan, RFLPScan, ZeroDScan, OneDScan, DocuGel and EPR; MicroArray Suite. Main products/instrumentation under R&D: Scanning imaging systems, scanning densitometer.

2490

SCANTIBODIES LABORATORY, INC.

Add: 9336 Abraham Way Santee, CA 92071 Tel: (619) 258-9300 Fax: (619) 258-9366 E-mail: [email protected] Web site: www.scantibodies.com President: Tom Cantor R&D expertise: R&D and manufacture of biotechnology drug products. Technological expertise: PMC, LP, BA, P/S, H/CF Principal products/instrumentation: Human serum, polyclonal antibodies, monoclonal antibodies, bivalent antibodies, complete antibodies, animal sera, second antibodies, protective antibodies, custom antibody, heterophilic blocking reagents; in vitro diagnostics. Main products/instrumentation under R&D: Monitoring methods of parathyroid hormone.

779

Subsidiary bodies: Penzberg, Germany; Paris, France; Milan, Italy; London, England. Sealed and granted patents: Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism. 7,056,655, U.S.

2491

SCHERING-PLOUGH CORPORATION

Add: 2000 Galloping Hill Road, Kenilworth, NJ 07033-0530 Tel: (908) 298-4000 Web site: www.schering-plough.com President/CEO: Fred Hassan R&D expertise: Discovery, research, development and production of biotechnological medicines and other drugs. R&D collaboration: Biogen Inc., Human Genome Sciences Inc. (HGS), Celltech Group plc, Genome Therapeutics Corp., Chiro-science Group plc, Sequus Pharmaceuticals, Myriad Genetics Inc., Endorecherche Inc., Orion Corp., Pharmacopeia, COR Therapeutics and Neurogen Corp. Technological expertise: AF, COC, DD, D-D, F, GT, HTDS, RD Principal products/instrumentation: Rebetron™ (recombinant combination rebavirin/ interferon alfa-2b) for treatment of chronic hepatitis C in patients who have relapsed following alpha interferon therapy and with compensated liver disease previously untreated with alpha interferon therapy, Eulexin capsules for prostate cancer; Fareston, oral anti-estrogen for hormone-dependent metastatic breast cancer in post-menopausal women; Intron® A, recombinant interferon alfa-2b injection for malignant melanoma, hairy cell leukemia, AIDS-related Kaposi’s sarcoma, follicular lymphoma, non-Hodgkins lymphoma, venereal warts, and hepatitis B and C; posaconazole

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(Noxafil) prophylaxis of invasive Aspergillus and Candida infections in patients; 1986~2006. Main products/instrumentation under R&D: p53 and RAS vaccine, p53 Tumor Suppressor Gene — for treatment of a variety of solid tumors, Phase I; p53 Tumor Suppressor Gene — lung cancer, Phase II; TEMODAL-brain metastases in malignant melanoma, Phase II; CAELYX2 — breast/ovarian cancer, Phase III; INTRON A — Non-Hodgkins lymphoma, Phase III; INTRON A — chronic myelogenous leukemia, pediatric hepatitis B, Filed; peginterferon-alfa-2b (PEG-Intron®), for treatment of chronic myelogenous leukemia, malignant melanoma, solid tumors, PhaseIII, 2008; Tenovil (interleukin-10, iL-10), for treatment for ischemic reperfusion injury, autoimmune disease, PhaseII, for hepatitis, Phase I/II; for acute lung injury, Phase I/II; psoriasis, rheumatoid arthritis, Phase III/IV, 2008; also Crohn’s autoimmune digestive, heart, infectious disease, etc.; melacine® melanoma theraccine (therapeutic vaccine) to treat stage II and IV malignant melanoma, Phase III/IV, 2008.

Principal products/instrumentation: PROTRAN®, OPTITRAN®, NYTRAN®, WESTRAN® — membranes, RAD-FREE® — detection kits, ISOCODE® — dipsticks, ELUTIP®, ELUQUIK® for DNA/RNA isolation, MINTFOLD® blotting units, CENTREX® centrifugal filters, REZIST® syringe filters, EXCELON® capsules. Main products/instrumentation under R&D: Ultrafiltration systems, DNA purification kits, biomolecular screening, blotting membrane. Subsidiary bodies: 10, Optical Ave, Keene, NH (U.S.A.).

2493

SCHLEICHER & SCHUELL, INC.

Add: 10 Optical Ave. P.O. Box 2012 Keene, NH 03431 Tel: (603) 352-3810 Fax: (603) 357-3627 E-mail: [email protected] Web site: www.s-and-s.com President: Peter Konstantin Research director: Michael Harvey, Ph.D.

2492

SCHLEICHER & SCHUELL GMBH

Add: Postfach 4 Dassel D-37582 Germany Tel: (49) 556-179-1417 Fax: (49) 556-179-1544 E-mail: [email protected] Web site: www.s-und-s.de CEO: Dr. Werner Specht Research director: Dr. Peter Konstantin R&D expertise: R&D and manufacture of paper, membranes, ultrafiltration systems, DNA-purification, blotting, detection, biomolecular screening. R&D collaboration: Fraunhofer Gesellschaft Technological expertise: Q, BA, P/S, HTDS, R, SMC, SY

R&D expertise: R&D and manufacture of medical products for life science research, biomolecular screening, filtration, and diagnostic components. Life Science products include blotting devices, transfer membranes and blotting paper for analysis of nucleic acids and proteins, DNA purification systems, and detection methods. New biomolecular screening products include customized slide and membrane platforms for micro and macro arraying. Technological expertise: RD, P/S, PMC, G, C/TC, HTDS, H/CF Principal products/instrumentation: RadFree® psoralen biotin and psoralen fluoreslein labeling systems for nucleic acids; FAST™ and CAST™ microarray slides, FAST Slide Micro Hybridization Kit; Grid and Grow™ Agarless colony growth matrix; IsoCode®

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STTX PCR template preparation dipsticks; Protran® Nitrocellulose; Optitran® supported nitrocellulose; Nytran® nylon and Westran® PVDF transfer membranes; TurboBlotter™ downward capillary transfer systems; Pronto™ semi-dray electro-blotter; DNA purification products; syringe and bottletop filters; 903™ specimen collection paper. Custom manufacturing for OEM diagnostic devices.

781

Research director: AL Rudolph, M.D. R&D expertise: Drug discovery research, development and commercialization of pharmaceuticals in targeted worldwide markets for chronic and life-threatening diseases including hepatitis B and C, HIV and cystic fibrosis. Key sales market contracts: Schering-Plough K.K. Japan, Sigma-Tau (Italy).

Main products/instrumentation under R&D: Proprietary products, biomolecular structure screening, DNA purification systems.

Key license and trade contracts: Alpha 1 Biomedicals Inc., Schering Plough K.K. (Japan), NTH.

Subsidiary bodies: Schleicher & Schuell GmbH, P.O. Box 4, D-37582 Dassel, Germany, Tel: (055) 61-791-0, Fax: (055) 61-791-533; Schleicher & Schuell AG, Lorracherstrasse 50, CH-4125 Riehen/BS, Switzerland, Tel: (061) 641-6900, Fax: (061) 641-6904; Schleicher & Schuell Nederland BV, P.O. Box 335,5201 AH’s-Hertogenbosch, The Netherlands, Tel: (0736) 31-31-00, Fax: (0736) 31-25-84; Schleicher & Schuell France SARL, BP 32, F-78920 Ecquevily, France, Tel: (134) 75-90-77, Fax: (134) 75-96-59; Schleicher & Schuell N.V7SA, Meerstraat 138, B-9000 Gent, Belgium, Tel: (329) 244-65-10, Fax: (329) 24465-11; Schleicher & Schuell Italia, S.r.L., Via Macello, 6,20025 Legnano, MI, Tel: (331) 599 631, Fax: (331) 599-632; Schleicher & Schuell PARATRADE, Tetenyi ut 71b, H-l 115 Budapest, Hungary, Tel: (1203) 85-27, Fax: (1203) 85-28.

Technological expertise: PIS, SY, DDI

2494

SCICLONE PHARMACEUTICALS, INC.

Add: 950 Tower Lane, Suite 900, Foster City, CA 94404-2125 Tel: (650) 358-3456

Principal products/instrumentation: ZADAXIN® Thymosin Alpha 1 for hepatitis C — received commercial approval in 22 countries worldwide including China, Italy, Mexico, Argentina, Singapore and Korea; Immunomodulators, biological response modifier, peptides, small molecules, xanthine derivative. Main products/instrumentation under R&D: ZADAXTN® thymosin alpha 1, Phase III/IV for hepatitis B in Taiwan completed, Phase II in Japan for hepatitis B, Phase III/IV for chronic hepatitis C in the U.S., Phase III/IV for HIV in Italy. CPX-preclinical trials in U.S. for cystic fibrosis; Thymalfasin for hepatitis, cancer, HIV; DAX for cystic fibrosis; SCV-07 for drug resistant tuberculosis, cancer; Hepatitis C, hepatitis B, hepatocellular carcinoma (HCC), malignant melanoma, cystic fibrosis, tuberculosis, analogs of thymosin alpha1. Sealed and granted patients: Analogs of thymosin.alpha.1. 6,262,230, U.S.; Treatment of hepatitis B infection with thymosin in combination with lamivudine or in combination lamivudine and famciclovir. 6,288,033, U.S.

2495

SCIENCE/ELECTRONICS, INC.

Fax: (650) 358-3469 E-mail: [email protected]

Add: 521 Kiser St. Dayton, OH 45404-1641

Web site: www.sciclone.com

Tel: (937) 224-4444

President/CEO: Donald R. Sellers

Fax: (937) 224-4434

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E-mail: [email protected] Web site: www.se-one.com CEO: T. R. Morton R&D expertise: Data logging and data logger manufacture/R&D for controlled temperature, equipment.

manufacturing products, diagnostics, instruments, in vitro toxicology testing, organ transplants/culture, plastics, reagents, toxic waste processing, veterinary vaccines, blood controls for coagulation, Nycomed™; molecular products, Dynabead/Dynal; RIA/EISA kits, DSL; Allergy Products, Pharmacia & Upjohn.

Technological expertise: BME Principal products/instrumentation: Squirrel data logger, data logging devices, grant controlled temperature equipment; contract manufacturing products, contract research/clinical trial products. Main products/instrumentation under R&D: Temperature sensor, temperature sensitive gene.

2497

SCIENTECH, INC.

Add: 5649 Arapahoe Ave. Boulder, CO 803031399 Tel: (303) 444-1361 Fax: (303) 444-9229 E-mail: [email protected] Web site: www.scientech-inc.com

2496

SCIENCE INTERNATIONAL CORPORATION

Add: 14/F Gee Tuck Bldg. 16-20 Bonham Strand East Hong Kong, P. R. China Tel: (852) 2543-7442 Fax: (852) 2541-4089 E-mail: [email protected] Web site: www.scienceintel.com President: Ian Tam Research director: Ricky Tong R&D expertise: R&D and manufacture and marketing of equipment/instruments for biopharmaceuticals/pharmaceuticals; technical service support; physical distribution; customer support of instrumentation; diagnostics; commercialization of medical instruments in Hong Kong and China.

President/CEO: Thomas O’Rourke, L.L.B. R&D expertise: Development and manufacture of electronic balances and laser power/ energy meters. Technological expertise: BME Principal products/instrumentation: Analytical balances, electronic balances, top loading balances, general purpose scales laser microprobe, laser power and energy meters and detectors. Floating Tare™ (balances), Mentor ™, Astral™, Vector™ and Synergy™ with laser power line of products. Main products/instrumentation under R&D: Laser microprobe, laser scanning confocal microscope, laser light scatter.

2498

SCIENTIFIC ADSORBENTS, INC.

Key sales market contracts: Marketing to all worldwide famous medical and diagnostic companies in Hong Kong and China.

Add: 3342 International Park Drive, Atlanta, GA 30316

Technological expertise: CC, E, F, BA, BS, CB, C/TC, COC, DD, GA, GT, G

Fax: (678) 904-6603

Principal products/instrumentation: Biologicals, biomaterials, biosensors, contract

Tel: (678) 904-6601 E-mail: [email protected] Web site: www.saiadsorbents.com

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President: Bryan E. Kepner Research director: Dr. Mark Moskovitz R&D expertise: Purification/chromatography research, related novel products manufacture.

783

Sealed and granted patents: ParaSafe, Mycolase.

2500

SCIENTIFIC INDUSTRIES, INC.

R&D collaboration: PEL Key sales market contracts: Alltech Associates, Inc.

Add: 70 Orville Dr. Bohemia, NY 11716

Technological expertise: F, CC, SY, COC, PMC, P./S, BA, RD, CB, HTDS, SMC, PIS, CH/S

Fax: (631) 567-5896

Principal products/instrumentation: Aluminas, Silicas, Bonded Phases, Desiccants, Desisphere™. Main products/instrumentation under R&D: Alumina for biomass, Decolorization Alumina for natural products, purified protein derivative (PPD), purified micro-environment technique, purification chromatography.

2499

SCIENTIFIC DEVICE LAB, INC.

Add: 411 E. Jarvis Ave. Des Plaines, IL 60018 Tel: (847) 803-9495

Tel: (631) 567-4700 E-mail: [email protected] Web site: www.scientificindustries.com President/CEO: Lowell A Kleiman R&D expertise: Development and manufacture of laboratory biomedical equipment. Technological expertise: BME Principal products/instrumentation: Vortex Mixer, vortex-GENIE 2®; CellDisrupter, TURBOMIX™; Shakers, rotators, ROTOSHAKE™; incubators, refrigerators, envirortmental chambers, enviro-Genie™. Main products/instrumentation under R&D: Laboratory scale purification devices, labwares, laboratory information management systems, other biomedical equipment.

Fax: (874) 803-8251 Web site: www.scientificdevice.com President: Dr. Stewart Lipton

2501

SCIENTIFIC PROTEIN LABORATORIES, INC.

Research director: Dr. Stewart Lipton R&D expertise: Development and manufacture of clinical microbiology and histology laboratory products.

Add: 700 E. Main St. P.O. Box 158 Waunakee, WI 53597

Technological expertise: TE, AF, BA, CH/S, P/S, BME

Fax: (608) 849-4053

Principal products/instrumentation: Contract manufacturing products, mycomycin diagnostic reagents, STAINS environmentally friendly fixatives parasitology and mycology products, electronics — ParaSafe, Mycolase.

Web site: www.spl-pharma.com

Main products/instrumentation under R&D: Microbialfilm, microbial pesticides, microbial sensor, histone.

Tel: (608) 849-5944 E-mail: [email protected] President: David Strunce Research director: Dr. Yan Wang Subsidiary of American Home Products CORP. R&D expertise: Research of bioprocess engineering, R&D/manufacture of bulk porcine

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pancreatic enzymes and heparins for pharmaceutical, veterinary, biotechnology and food industries; special products development from clinical trials through commercial production. cGMP compliant and USDA/FDA inspected facility. Technological expertise: P/S, LP Principal products/instrumentation: Biologicals, enzymes, specialty chemicals, contract manufacturing products, process validation, bioproducts, bioreactor. Main products/instrumentation under R&D: Porcine pancreatic enzymes, bioprocess engineering technique.

2503

SCIENTIFIC SPECIALTIES SERVICE, INC.

Add: 7201 Standard Drive,Hanover, MD 21076 Tel: (800) 648-7800 E-mail: [email protected] Web site: www.scispec.com President: Steven Grebow Research director: Marc Grebow R&D expertise: Development and manufacture of glass and plastic vials, bottles and jars for health research and environmental testing. Technological expertise: P/S

2502

SCIENTIFIC RESEARCH CONSORTIUM, INC.

Main products/instrumentation under R&D: Specially cleaned containers for biological storage, plastic wares, glasswares, glass pipette.

Add: 1769 Lexington Ave. N., Ste. 321 St. Paul, MN 55113-6522 Tel: (651) 489-8939 Fax: (651) 489-8985 E-mail: [email protected]

2504

SCIEX DIVISION OF MDS HEALTH GROUP, LTD.

Web site: www.aminoacids.com

Add: 71 Four Valley Dr. Concord, Ontario L4K 4V8 Canada

President: Frank N. Konstantinides

Tel: (905) 660-9005

R&D expertise: Nutrient analysis, development/ manufacture of amino acids, cell culture media, protein, fermentation materials, bioreactors, fatty acids, and vitamins.

Fax: (905) 660-2600

Technological expertise: F, TE, T, C/TC, GT, H/CF Principal products/instrumentation: Bioreactor, adequate proteins, biologicals, biomaterials, bioremediation, specialty chemicals, complete proteins, diagnostics, food processing, natural products, organ transplants/culture, pharmaceuticals, veterinary products, contract R&D and manufacture products. Main products/instrumentation under R&D: Nutrient, nutrient drugs, nutritional supplements, cell culture media, fermenter.

E-mail: [email protected] Web site: www.mdssciex.com President: Bill Garrick Research director: Bill Davidson Subsidiary of MDS Health Group Ltd. R&D expertise: R&D and manufacture of bioanalytical instrumentation and mass spectrometry products. Joint ventures: Perkin Elmer (API LC/MS and LC/MS/MS, Han ICP/MS). R&D collaboration: Biomedical Research Center (protein sequencing), NRC Institute for Marine Biosciences (bioanalytical instrumentation).

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Key license and trade contracts: University of Alberta, University of British Columbia, Cornell University, University of Toronto.

by weight or by volume; Tandem — a high precision, dual channel peristaltic pump head; Inline Precalibrated Sensors, 2007.

Technological expertise: Q, CH/S, BME

Main products/instrumentation under R&D: Patents pending instrumentation for further automation of filtration, Scilog smart pump for biotech drugs labs.

Principal products/instrumentation: Bioanalytical Elan 6000 ICP/MS, API III Plus LC/MS/MS, API I LC/xMS. Main products/instrumentation under R&D: Bioanalyser, mass spectrometer.

2505

SCILOG, INC.

Add: 8845 S.Greenview Dr. Middleton, WI 53362-2562 Tel: (608) 955-1933 FAX: (608) 824-0509 E-mail: [email protected] Web site: www.scilog, com President: Juliette Schick, Ph.D. Research director: Karl Schick, Ph.D. R&D expertise: Research, design, development and marketing of SciLog Smart Pumps for chemical, pharmaceutical and biotech drugs labs and process areas. SciLog’s products easy-to-use, modestly priced automation of liquid handling applications. SciLog product systems include a variety of pump heads, peristaltic, piston, magnetic gear and lobe models. Key license and trade contracts: Dr. Karl Schick Technological expertise: F, PA, BA, C/TC, PIS, PMC, P/S, SY Principal products/instrumentation: SCIPRO — a smart, mobile, batch process pumping system, used for automating laboratory ultrafiltration, microfiltration and diafiltration applications; ACCU — a digital, high precision pump used with a PC; The LabTec — a high precision, rapid dispenser/filler; ChemTec — a high precision metering system that can meter

Sealed and granted patents: #5,947,689 for automating filtration; #5,340,290 for tandem head.

2506

SCIMERICAS, S.A. DE C.V.

Add: Cerrada de Rio Becena 112, Ay C Col. 8 de Agosto Mexico, D.F. 03820 Mexico Tel: (52) 5516-4039 E-mail: [email protected] Web site: www.scimericas.com President: Mark G. Sortwell R&D expertise: Development and production/ marketing of laboratory equipment and labwares. Technological expertise: CH/S, BME Principal products/instrumentation: Biological safety cabinets, autoclaves, water baths, incubators, Amerex Instruments, refrigerators and freezers, Harris and Puffer Hubbard.

2507

SCINOPHARM INT’L, LTD.

Add: 1710 S. Amphlett Blvd. Ste. 220 San Mateo, CA 94402 Tel: (650) 655-2013 Fax: (650) 655-2014 E-mail: [email protected] President/CEO: Josephine Shen, Ph.D. Research director: Hardy W. Chan, Ph.D. R&D expertise: Manufacture/development and marketing of fine chemically synthesized active pharmaceutical ingredients.

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Technological expertise: CC, AF, CS Principal products/instrumentation: Fine chemicals, contract manufacturing products, natural products, pharmaceutical ingredients.

2508

of peptides. 6,828,303, U.S.; Systems for the analysis of gene expression data. 6,263,287, U.S.; Modulation of Abeta levels by beta-secretase BACE2, 6,713,276, U.S.; beta-secretase and modulation of beta-secretase activity. 7,087,399, U.S.

SCIOS, INC.

Add: 1900 Charleston Road Mountain View, CA 94039 CA Tel: (650) 564-5000 Fax: (650) 564-7070 Web site: www.sciosinc.com

2509

SCIPAC, LTD.

Add: Broad Aok Rd. Sittingbourne, Kent ME9 8AQ U.K. Tel: (44) 179-542-3077 Fax: (44) 870-622-2132

President/CEO: Richard B. Brewer

E-mail: [email protected]

Research director: John A Lewicki, Ph.D.

Web site: www.scipac.com

R&D expertise: Development and manufacture of biotechnology drug products.

President: Simon Packer

R&D collaboration: Eli Lilly, DuPont Pharmaceuticals. Key sales market contracts: Halbol decanoate (J&J), psychiatry products (SB), EFFEXOR — Wyeth-Ayerst. Key license and trade contracts: Chiron, Genvec. Technological expertise: CB, G, RDS, PS, PS/AP, T, PIS Principal products/instrumentation: Natrecor® BNP for treatment of acute congestive heart failure. Main products/instrumentation under R&D: Natrecor ® BNP for treatment of acute congestive heart failure, Phase III/IV; systems for the analysis of gene expression data, Fiblast® growth factor, for treatment of peripheral vascular disease, coronary artery disease, etc., Phase II; Vegf 121® (vascular endothelial growth factor) for treatment of cardiovascular disorders, Phase III, 2008; Insulinotropin for treatment of type 2 diabetes, Phase II, 2008. Sealed and granted patents: Human BNP; recombinant production of basic FGF; transgenic Alzheimer’s mouse, prolonged delivery

R&D expertise: Development and production of diagnostic reagents. Technological expertise: PA, C/TC, P/S Principal products/instrumentation: Diagnostic reagents — paramagnetic particles, contract manufacturing products, biologicals, specialty chemicals. Main products/instrumentation under R&D: New human proteins.

2510

SCIQUEST, INC.

Add: 6501 Weston Parkway, Suite 200, Cary, NC 27513 Tel: (919) 659-2100 Fax: (919) 659-2199 Web site: www.sciquest.com President: Andrew McKenna R&D expertise: Development of scientific laboratory products, information supply and R&D services. R&D expertise: BI, CH/S, G, HTDS Principal products/instrumentation: Biologicals, biomaterials, specialty chemicals,

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detergents, diagnostics, human genome project, instruments, reagents, chemical libraries. Customers’ enterprise system, internal inventory system.

Research director: David Rogers

Main products/instrumentation under R&D: Laboratory reagents, laboratory information/ management system, labwares.

Technological expertise: Q, PMC, BI, COC, CH/S, DD, HTDS

2511

SCITEC, INC.

Add: 5025 Galley Road, Colorado Springs, CO 80915 Tel: (719) 638-8821 Fax: (719) 638-8815 E-mail: [email protected]

R&D expertise: Development and manufacture of software of biotechnology medicine research and other systems.

Principal products/instrumentation: Pipeline Pilot, SciTegic data analysis and mining software to the pharmaceutical and biotechnology sectors. Best possible systems for streamlining the processing of the growing sources of diverse data types in today’s life science research environment. Main products/instrumentation under R&D: Computer-aided biotech medicine analytical software, computer aided testing system.

Web site: www.scitecinc.com President/CEO: Jean-Louis Rufener Research director: Jean-Marc Haab R&D expertise: R&D of laboratory automation and robotics; related novel products development and manufacture. Technological expertise: E, PA, COC, CH/S, HTDS, PIS, P/S, SMC Principal products/instrumentation: CLARA scheduling and control software for robotics, CYCLONE-96 Tip Pipetting device. Main products/instrumentation under R&D: Laboratory automation computer control, robotics-aided drug design.

2512

SCITEGIC

Add: 4540 Kearny Villa Rd. Ste. 224 San Diego, CA 92123 Tel: (858) 799-5509 Fax: (858) 799-5102 E-mail: [email protected] Web site: www.accelrys.com President/CEO: Mathew Hahn

2513

SCIVISION, INC.

Add: 200 Wheeler Rd. Burlington, MA 01803 Tel: (781) 272-4949 Fax: (781) 272-6868 E-mail: [email protected] Web site: www.scivision.com President: Joseph R. Votano, Ph.D. Research director: Victor Aronov R&D expertise: R&D and manufacture of chemistry and biochemistry software, drug discovery; polymer and glass science products. Key license and trade contracts: IBM, Tripos. Technological expertise: CH/S, D-D, BI, COC, BTS, P/PS, PPAT, POS, PLHDDT Principal products/instrumentation: SciLogP, SciQSAR, SciProtein, SciPolymer, SciGlass, SciQSAR 2D, Spectral Atlas; Alchemy 2000; Handbook of Optical constants; Ion Fingerprint software; TOXIS; QSARIS; ONCOIS, Biomed Source, GlassIS (new products). Main products/instrumentation under R&D: Life and material information systems PolymerlS,

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Combils; polymer drug, polymerized liposome, biochemistry software.

2514

SCOTTISH ANTIBODY PRODUCTION UNIT

Principal products/instrumentation: Biologicals, biomass, biomaterials, bioremediation, biosensors, human genome project, instrumentation, in vitro toxicology testing, natural products, organ transplants/culture, pharmaceuticals, vaccines, veterinary products, specialty chemicals.

Add: At Law Hospital Carluke Lanarkshire, Scotland ML8 5ES U.K. Tel: (44) 698-351-161 Fax: (44) 698-359-376 Web site: www.show.scot.nhs.uk/sapu/ President: A. C. Munro Research director: D. Fatori R&D expertise: R&D of polyclonal and monoclonal antibody, manufacture of both finished and bulk products. Technological expertise: PA, C/TC, H/CF Principal products/instrumentation: Contract manufacturing products, diagnostics, reagents, monoclonal antibodies, polyclonal antibodies.

2515

SCOTTISH BIOMEDICAL FOUNDATION, LTD.

Add: Telford Pavilion, Todd Campus, West of Scotland Science Park, Glasgow G20 0XA5

2516

SCREENARRAY, INC.

Add: 245 Aspen Rd. Yardley, PA 19067 Tel: (215) 493-0945 E-mail: [email protected] President: G. Washinger Research director: D. Talbot, Ph.D. R&D expertise: R&D and manufacture of products for high throughput drug screening. Genes, oligos, molecules on membranes, glass, reagents and detection instrumentation. Technological expertise: GA, G, HTDS, PG, P/S, SY Principal products/instrumentation: “Biorational” arrays, high throughput drug screening, high throughput screenarray. Main products/instrumentation under R&D: Gene synthesis technique, gene screen, oligogene, oligonucleotide.

Tel: (44) 141-587-6100 Fax: (44) 141-587-6110 E-mail: [email protected]

2517

SCRIPPS LABORATORIES

Web site: www.scottish-biomedical.com.

Add: 6838 Flanders Drive, San Diego, CA 92121-2904

CEO: Dr. Stephen Hammond

Tel: (858) 546-5800

Research director: Dr. Morag McFarlane R&D expertise: R&D of technology transfer from a large network of top Scottish universities to pharmaceutical and biotechnology companies. Technological expertise: E, PA, Q, TE, T, AF, AB, CB, C/TC, GA, G, P/S, RD, SMC, SY, COC, DD, D-D

Fax: (858) 546-5812 E-mail: [email protected] Web site: www.scrippslabs.com President: Simon C. Khoury R&D expertise: Isolation and purification research of human proteins (hormones, cardiac and cancer markers, etc.) and their

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associated paired antibodies. Contract R&D and manufacturing. Joint ventures: Clinical Diagnostics Ltd., Thailand. R&D collaboration: Clinical Diagnostics Ltd., Thailand. Key sales market contracts: Clinical Diagnostics Ltd., Thailand. Technological expertise: PA,, RD, C/TC, H/CF, P/S, AB, MAE, P/PS, PPAT, E, ERT, ET Principal products/instrumentation: Human pituitary hormones including alpha and beta subunits, animal hormones, human serum proteins, human cancer/tumor markers, human cardiac markers, clinical diagnostic and EIA enzymes, immunodiagnostic biochemicals, inactivated viruses, immunochemicals including monoclonal and polyclonal antibodies, colloidal gold conjugates; immunodiagnostic calibrators and controls. Main products/instrumentation under R&D: Monoclonal antibodies to PSA-ACT Complex, Free-PSA, CK-MB, Myoglobin, and HbsAg. Monoclonal and polyclonal antibodies to cardiac Troponin I. Carbonic Anhydrase III and Glycogen Phophorylase BB (GPBB) antigens; Human proteins from cell culture; One-step, lateral flow clinical diagnostic tests. Subsidiary bodies: Scripps Laboratories Japan Inc., 5-3-7, Koishikawa, Bunkyoku, Tokyo 112 Japan, Tel: (813) 3818-7631, Fax: (813) 3818-4453.

789

Research director: Lee Crosby R&D expertise: R&D and manufacture/marketing of products for the life science laboratory research. Technological expertise: PA, COC, BME Principal products/instrumentation: Contract manufacturing products, SensiTek™, UltraTek™ and Mouse-To-Mouse™ immunohistochemical staining systems, single component chromogenic substrates. Numerous biological stains.

2519

SEA RUN HOLDING, INC.

Add: 76 Pine St. Freeport, Maine 04032 Tel: (207) 772-2054 E-mail: [email protected] President: Evelyn S. Sawyer R&D expertise: Development and manufacture of biologicals from fish. Technological expertise: C/TC, BS Principal products/instrumentation: Biologicals, natural products, Sea-Block, Sea-Grow. Sealed and granted patents: 5 patents.

2520

SEATECH BIOPRODUCTS CORP.

Add: 159 Memorial Dr. Unit C Shrewsburg, MA 01545-4030 Tel: (508) 842-9292

2518

SCYTEK LABORATORIES, INC.

Fax: (508) 842-9020 President: Jame Hugher, Ph.D

Add: 205 South 600 West Logan, UT 84321

Research director: J. R. Schmidt, Ph.D.

Tel: (435) 729-8350

R&D expertise: R&D and manufacture/ marketing of marine pharmaceuticals, biochemicals, nutraceuticals, biomaterials, raw materials for further processing.

Fax: (435) 755-0015 E-mail: [email protected] Web site: www.scytek.com President/CEO: Michael Anderson

Technological expertise: E, F, PA, P/S, AF, BI, PMC, PIS, LP, BA, MP, RM

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Principal products/instrumentation: Marine oil fractions as raw material for pharmaceuticals agents, marine bone and cartilage extracts, marine invertebrate extracts, marine carotinoids, natural products, specialty chemicals, enzymes.

Tel: (613) 9-263-4300

Main products/instrumentation under R&D: Marine medicinals, marine lipid concentrate, nutraceuticals, nutrient, nutrient drug.

Subsidiary of Salmond Smith Biolab.

2521

SEEDNA BIOTECH, INC.

Add: 443 Ouellette Ave. Ste. 100 Windsor, Ontario N9A 4J2 Canada Tel: (519) 252-8669 Fax: (519) 252-2915 E-mail: [email protected]

Fax: (613) 9-562-9840 E-mail: [email protected] CEO: Wayne Powell R&D expertise: Development and manufacture of all biomedical laboratory equipments, instrumentation and consumables. Technological expertise: BME, SI Principal products/instrumentation: Special reagents, laboratory biomedical equipments, labwares. Main products/instrumentation under R&D: Computer-aided laboratory pharmaceutical analysis, automatic DNA sequencer.

Web site: www.seedna.com President: Dr. Henry Heng

2523

SELECTIDE CORP.

Research director: Dr. Christine Ye R&D expertise: Services development and products manufacture of gene mapping, gene medicine/genome analysis and functional genomic, etc. Key sales market contracts: TOMY SEIKO CO., LTD. (Japan). Technological expertise: T, C/TC, GT, G, P/S, RD Principal products/instrumentation: Contract research products, human genome project, gene map, gene complex.

Add: 1580 E. Hanley Blvd. Tucson, AZ 85737 Tel: (520) 544-5800 Fax: (520) 575-8283 President: Philippe Bey Research director: Michael Kolb Subsidiary of Hoechst Marion Roussel. R&D expertise: Drug discovery, design, drug screening, development and production. Key license and trade contracts: University of Arizona.

Main products/instrumentation under R&D: Gene mapping by in situ hybridization.

Technological expertise: HTDS, D-D, DD, DDI, COC

Sealed and granted patents: Gene mapping by in situ hybridization to free chromatin. U.S. patent #5,470,709, Canadian patent # 2,078,377; other patents pending.

Main products/instrumentation under R&D: Pharmaceuticals, Factor Xa Inhibitor, MDL 21,2906; drug delivery platform, drug design through disjunction.

2522

SELBY-BIOLAB

Add: 2 Clayton Rd. Clayton Melbourne, Victoria 3168 Australia

2524

SEMINIS

Add: 800 North Lindbergh Blvd. Saint Louis, MO 63167

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Tel: (314) 694-1000 E-mail: [email protected] Web site: www.seminis.com President: Alejandro Rodriguez Research director: Allen Stevens Subsidiary of Seminis Inc. R&D expertise: R&D and manufacture/marketing of vegetable seeds breeding. R&D collaboration: Monsanto, Zeneca, DNAP, and others. Technological expertise: T, AB, BI, C/TC, GA, RD Principal products/instrumentation: Agriculture, larger variety of vegetable varieties, mostly hybrids. Main products/instrumentation under R&D: Transgenic varieties, disease resistant and product quality field tests.

2525

SENN CHEMICALS AG

791

Main products/instrumentation under R&D: Peptide synthesizer, peptide sequencer, peptide ELISA. Subsidiary bodies: Senn Chemicals International, 11, rue Jean Baptiste Clement, F-94250 Gentilly; Senn Chemicals U.S.A., Inc. 3550 General Atomics Court, Bldg. 2, Room 441, San Diego, CA, 92124.

2526

SENSOR BASED SYSTEMS, INC.

Add: P.O. Box 456 Dublin, PA 18917 Tel: (215) 249-1390 Fax: (215) 249-1751 E-mail: [email protected] President: Lisa S. Krause R&D expertise: R&D and production/supply of tools for bioresearch, bioprocess, and contract packaging. Key sales market contracts: Forte, Monitek, Newport Biosystems, Valley Instruments, Moindustries, Eagle SS and GPSI.

Add: Industriestrasse 12, CH-8157 Dielsdorf, Switzerland

Key license and trade contracts: Cormar, TMI-U.S.A. and Vapex

Tel: (41) 43-422-2400

Technological expertise: BA, PMC, BME

Fax: (41) 43-422-2424

Principal products/instrumentation: Cell density monitoring, disposable bag sterile filling systems, process control instrumentation, disposable media and product collection bag systems.

E-mail: [email protected] Web site: www. sennchem.com President: Thomas Senn Research director: Christof Senn R&D expertise: Research of peptides and peptide instrumentation, novel products development.

Main products/instrumentation under R&D: Tools of bioprocess technology for bioresearch.

Technological expertise: CS, PI. Principal products/instrumentation: Production of peptides including TRH (Thyroliberin) and TRH tartrate, protected amino acids as starting material for peptide synthesis, protected peptide fragments on custom basis.

2527

SENTRON

Add: Transportstraat 1, B-3980 Tessenderlo, Belgium Tel: (32) 1367-0780 Fax: (32) 1367-2134

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E-mail: [email protected]

Tel: (972) 7-684-2078

Web site: www.sentron.ch

Fax: (972) 7-684-2131

Subsidiary of Priva Group.

E-mail: [email protected]

R&D expertise: R&D and manufacture of pH systems based on ion sensitive field effect transistor (ISFET) technology and non-glass pH systems based on ISFET technology.

CEO: Alex Soskin

Technological expertise: BME, CW Principal products/instrumentation: Contract manufacturing products, ISFET pH sensors, non-glass pH probes, pH meters.

Research director: Ginady Borodyaski Subsidiary of Western Negev Initiative Center. R&D expertise: Development and production of algae. Technological expertise: AB Markets: Agriculture.

2528

SENTRY EQUIPMENT CORP.

Add: 966 Blue Ribbon Circle North, P.O. Box 127, Oconomowoc, WI 53066

Main products/instrumentation under R&D: Micro algae separator device, algin, algocyan.

2530

SEPRAGEN CORP.

Tel: (262) 567-7256 Fax: (262) 567-4523 E-mail: [email protected] Web site: www.sentry-equip.com President/CEO: Mike Farrell Research director: Scott Raether R&D expertise: Development and production of sampling equipment, sample coolers, process and steam/water sampling components. Technological expertise: BME, CS Principal products/instrumentation: Chemicals, sampling equipment, nutraceuticals, pesticides, biopharmaceuticals, plastics. Main products/instrumentation under R&D: Sample conditioning equipment, sample coolers, compact heat exchangers, sampling panels and instrumentation, sample injector, needlefree drug delivery systems, needle sampler. Sealed and granted patents: VREL®, needle sampler.

Add: 1205 San Luis Obispo Avenue, Hayward, CA 94544 Tel: (510) 475-0650 Fax: (510) 475-0625 E-mail: [email protected] Web site: www.sepragen.com President/CEO: Vinit Saxena Research director: Salah Ahmed R&D expertise: Bioprocess engineering research, development of proprietary processes and products using radial flow chromatography in biotech, diary, food, and nutraceutical industries. Major partners: Alpha Therapeutics, Baxter, Chiron Corp., Green Cross, Schering-Plough, Chugai Pharmaceuticals, Hoechst, Glaxo/ Wellcome, Amgen. Joint ventures: Anchor Products, Carbery Milk Products.

SEPAL TECHNOLOGIES

Key sales market contracts: BAS Technicol Ltd., YMC, KronLab, Analis, QuiXave Biolink Inc.

Add: P.O. Box 321 Neve Dekalim 79779 Israel

Technological expertise: T, LP, RD, P/S, BA, PMC

2529

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Principal products/instrumentation: Biologicals, antibiotics, single cell proteins, vaccines, enzymes, monoclonal antibodies, radial flow Superflo™ chromatography column, QuantaSep™ purification system, large-scale process control workstations, SepraSorb™ resin, Wedge™ columns and SepraPrep™ resins. Main products/instrumentation under R&D: Ver 2.2 software, Quadetector, process controllers. Sealed and granted patents: 16 — columns, media, SepraLac, SepraDebit process.

2531

SEQ, LTD.

Add: Nerin House, 26 Ridgeway Street, Douglas, Isle of Man, IM1 1EL, U.K. 17 Princess Rd., Stes. A-H Lawrenceville, NJ 08648 Tel: (44) 162-469-2999 Fax: (44) 162-461-3998 E-mail: [email protected]

2532

793

SEQUANA THERAPEUTICS, INC.

Add: 11099 North Torrey Pines Rd., Suite 160 La Jolla, CA 92037 Tel: (619) 452-6550 Fax: (619) 452-6653 E-mail: [email protected] President/CEO: Kevin J. Kinsella Research director: Tim Harris, Ph.D. R&D expertise: Research of gene discovery and characterization, related novel products development and production. R&D collaboration: Glaxo, Boehringer Ingelheim, Corange. Technological expertise: Q, RD, R, SY, BI Principal products/instrumentation: Gene knock-out, novel gene, Human Genome Project, gene medicine. Main products/instrumentation under R&D: Genechip, gene duplication technique, gene probe, gene library, gene characterization analysis.

Web site: www.seq.co.im President/CEO: Robert F. Johnston Research director: Jay K. Trautman, Ph.D. R&D expertise: R&D of breakthrough technology for high throughput screening and for DNA sequencing. R&D collaboration: Bristol-Myers Squibb Co., Zeneca. Technological expertise: E, Q, BI, HTDS Principal products/instrumentation: High throughput screening technology, DNA sequencing, Human Genome Project, pharmaceuticals. Main products/instrumentation under R&D: Breakthrough technology for drug screening and sequencing. Sealed and granted patents: 2 patents.

2533

SEQUENOM, INC.

Add: 3595 John Hopkins Court, San Diego, CA 92121-1331 Tel: (858) 202-9000 Fax: (858) 202-9001 E-mail: [email protected] Web site: www.sequenom.com President/CEO: Toni Schuh, Ph.D. Research director: Charles Cantor, Ph.D. R&D expertise: Research and discovery of medical utility for genetic variations; novel products development and manufacture. Joint ventures: Methexis, Gemini Genomics. R&D collaboration: National Institutes of Health, National Cancer Institute, Genaissance

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Genomics, Boston University, Specialty Labs, USDA, Metabion GmbH, GSF.

Web site: www.sequetech.com

Technological expertise: BI, G, PG, DDI, BTS

R&D expertise: Contract DNA sequencing R&D services.

Principal products/instrumentation: Mass ARRAY System™, SpectroCHIP™, SNP Assay Portfolio, SNP Frequency Database. Main products/instrumentation under R&D: SNP Novel Frequency Database, solid phase DNA analysis, solid phase sequencing of nucleic acids. Sealed and granted patents: Mass Spectrometry Method, Solid Phase DNA Analysis Nucleic Acid Immobilization Sample Conditioning, DNA Bank Development, Multiplexing Method; Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules. 6,558,902, U.S.; DNA typing by mass spectrometry with polymorphic DNA repeat markers. 6,764,822, U.S.; Mass spectrometric detection of polypeptides. 6,387,628, U.S.; Methods of screening nucleic acids using volatile salts in mass spectrometry. 6,468,748, U.S.; Base-modified nucleotides and their use for polymorphism detection. 6,994,998, U.S.; Solid phase sequencing of double-stranded nucleic acids. 6,991,903, U.S.; Primers useful for sizing nucleic acids. 6,949,633, U.S.; Releasable nonvolatile mass label molecules. 6,635,452, U.S., Releasable nonvolatile mass-label molecules.7,132,519, U.S. Fluorescence-based genotyping. 6,855,500, U.S.; Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods. 20070141570, U.S.

2534

SEQUETECH CORP.

Add: 935-C Sierra Vista Ave. Mountain View, CA 94043 Tel: (415) 967-8685 Fax: (415) 967-8542 E-mail: [email protected]

President: A. Michael Chin, Ph.D.

Technological expertise: Q, S Principal products/instrumentation: DNA sequence analysis, DNA sequence comparison, DNA sequencer, DNA sequencing technique.

2535

SEQUITUR INCORPORATED

Add: 14 Tech Circle Natick, MA 01760 Tel: (508) 650-1459 Fax: (508) 655-1625 E-mail: [email protected] President: Dr. Tod Woolf, VP Research director: Dr. Peggy Taylor Subsidiary of Invitrogen. R&D expertise: Contract research of antisense technology and novel products development. R&D collaboration: Mitotic, Inex Pharmaceuticals, Genome Therapeutics, Phamacia & Upjohn, Monsanto- Searle, Genetics Institute, Amgen, Incyte, Wyeth Ayerst, BMS. Key license and trade contracts: Chiron. Technological expertise: AB, C/TC, SMC, G, PPAT, P/PS Principal products/instrumentation: Antisense strand “contract research/clinical trial products”, “Next Generation Oligomers™’’; Oligofectin™, lipids for cellular delivery. Main products/instrumentation under R&D: Protein Expression Technology, preclinical; sense mRNA therapy; three component chimeric antisense oligonucleotides. Sealed and granted patents: “Sense mRNA Therapy” (Woolf, Widerholt and Taylor); Three component Chimeric Antisense Oligonucleotides.

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2536

SEQUUS PHARMACEUTICALS, INC.

Add: 960 Hamilton Ct. Menlo Park, CA 94025 Tel: (415) 323-9011

795

Principal products/instrumentation: Bodipy dye primers, shotgun library construction kits. Main products/instrumentation under R&D: DNA sequence, DNA sequence comparison, DNA sequence analysis.

Fax: (415) 324-3928 Web site: www.sequus.com

2538

SERADYN

President: L. Scott Minick Research director: Joseph Vallner, Ph.D. R&D expertise: Development and manufacture of pharmaceutical/biopharmaceutical products for critical care market.

Add: 7998 Georgetown Rd. Ste. 1000 Indianapolis, IN 46268 Tel: (317) 428-4072 Fax: (317) 610-3888

Key sales market contracts: Distribution agreement with Zeneca Ltd.

E-mail: [email protected]

Technological expertise: D-D, DD, AF

President: Dave Taus

Principal products/instrumentation: AMPHOCIL™ in the U.K., Approvable Letter received from FDA for DOXIL®.

Research director: Dr. Mark Stobaugh

Web site: www.seradyn.com

Subsidiary of Alexon-Trend

Main products/instrumentation under R&D: Therapeutic liposome compositions.

R&D expertise: R&D of microparticles, diagnostic, and molecular biology, contract related products manufacturing.

Sealed and granted patents: Therapeutic liposome composition and method of preparation, 6,316,024, U.S.

Technological expertise: PA, P/S, COC, HTDS, PIS

2537

SEQWRIGHT

Add: 2575 West Bellfort, Suite 2001, Houston, TX 77054 Tel: (713) 528-4363 Fax: (713) 528-6232 E-mail: [email protected]

Principal products/instrumentation: Contract manufacturing products, Sera-mag linemagnetic particles [carboxylate modified; streptavidin; oligo(dT)]; OptiBind-Polystyrene particles (carboxylate-modified; dyed; fluorescent); therapeutic drug monitoring assays based on microparticle technology. Main products/instrumentation under R&D: Micropreparative technique, microprobe, microdiagnostic technique.

Web site: www.seqwright.com President: Richard Gibbs, Ph.D.

2539

SERATEC

Research director: Fei Lu, M.D. R&D expertise: Research of DNA sequencing, related novel products development.

Add: Place Blumental Epinay Sur Seine 93800 France

Technological expertise: Q, BI, GA, P/S, RD, G

Tel: (33) 48-226-182 E-mail: [email protected]

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Web site: www.seratec.com

2541

SERONO LABORATORIES, INC.

President: Reveilleau Antoine Research director: Rorenga Jazek R&D expertise: R&D and production of peptides, peptide instrumentation. Oligonucleotides synthesis, antisense, nucleotide sequencing, and fine biochemical synthesis. Joint ventures: Colored peptides enzyme substrates, reporter group Luminarine. Technological expertise: CC, E, Q, CS, AB, SY, C/TC, COC, D-D, PIS, SMC Principal products/instrumentation: Pharmaceuticals, fine biochemical, chiral separation, chromogenic substrates; peptides including Ala-Gln, Ala-Phe-Lys-OH, TbocLeu-Arg-OH, BOC-Ala-PhE-OH, Ala-GluOH, tFA-Lys-Gln-OH. Main products/instrumentation under R&D: Oligonucleotide synthesizer, fine biochemical synthesizer, nucleotide sequencer.

2540

SERAVAC USA, INC.

Add: 13220 Evening Creek Dr. San Diego, CA 92128 Tel: (619) 679-4050 Fax: (619) 679-1438 E-mail: [email protected] President/CEO: Brian Augustus, Ph.D. R&D expertise: Research and production of enzymes and protein. Technological expertise: E, F, P/S, BA, ET, ERT Principal products/instrumentation: Contract manufacturing products, enzymes, chiefly horseradish peroxidase, alkaline phosphatase, trypsin, chymotrypsin, DNase, RNase. Main products/instrumentation under R&D: Protein disulfide isomerase, enzyme inhibitor complex, ELISA. Subsidiary bodies: Cape Town, South Africa.

Add: 100 Longwater Circle Norwell, MA 02061 Tel: (617) 982-9000 Fax: (617) 871-6754 President: Hisham Samra, M.D. Subsidiary of Ares-Serono Group. R&D expertise: Development, production and marketing of biopharmaceuticals for the treatment of infertility, growth and metabolism and immunology/oncology research. Technological expertise: D-D, RD Principal products/intrumentation: Pergonal, Metrodin®, Serophene®, Sevostim™ (somatropin, rDNA origin for injection) treat AIDSassociated catabolism/wasting, short bowel syndrome and pediatric HIV failure to thrive, Profasi®, Serocryptin®, Relisorm L®, Saizen®, Geref® (human growth hormone-releasing factor, for treatment of pediatric growth hormone deficiency, evaluation of the ability of the somatograph of the pituitary gland to secrete growth hormone), Gonal-F® (recombination human follicle-stimulating hormone, rhFSH), for female infertility/improved treatment. Main products/instrumentation under R&D: IL-6, recombinant human tumor necrosis factor-binding protein-1 (rhTBP-1) for treatment of rheumatoid arthritis, digestive, heart disease, Phase II/III; recombinant gonadotropins; Rebif® (human interferon beta-1α), early treatment of multiple sclerosis, treatment for Guillain-Barre syndrome, cancer, digestive, infectious diseases, neurologic, Phase III, 2008; treatment of non-small-cell lung cancer, Phase III, 2008; somatropin (serostim), rDNA origin for injection, treatment of short bowel syndrome and lipodystrophy, Phase III, 2008; treatment of growth hormone deficiency in adults, Phase III/IV, 2008; Ovidrel®, recombinant human chorionic gonadotropin (r-hCG) to treat breast cancer, Phase II/III.

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Sealed and grated patents: 76 Pacella Park Drive, Randolph, MA 02368

2542

SEROTEC, INC.

Add: 3200 Atlantic Avenue, Ste 125, Raleigh, NC 27604, U.S.A. Tel: (919) 878-7978 Fax: (919) 878-3751 E-mail: [email protected] Web site: www.abdserotec.com President: E. Bernard Research director: Dr. R. Lang R&D expertise: R&D and manufacture of novel products of biotechnology medicines.

797

R&D collaboration: CRC, U.K. Technological expertise: PA, CS, PMC, F/TC Principal products/instrumentation: Reagents, hollow fiber bioreactor; antibodies to human, rodent and veterinary antigens; cytokine and growth factor products; inhibin assays; bioreactor, cell adhesion molecule products, apoptosis reagents. Main products/instrumentation under R&D: Cell and tissue culture, high quality antibodies, immunological reagents. Subsidiary bodies: Serotec, Inc., NCSU, Centennial Campus, Partners 1, 1017 Main Campus Dr., Suite 2450, Raleigh, NC 27606, Tel: (800) 265-7376, (919) 515-9977, Fax: (919) 515-9980, E-mail: [email protected]

Technological expertise: PA, H/CF, C/TC, AB Principal products/instrumentation: Antibodies to human, mouse and rat markers such as CD markers, immmunoglobulins, adhesion markers, MHC antigens — many of these are manufactured in the U.K. Subsidiary bodies: Head office, Serotec Ltd U.K.

2544

SERQUEST (A SOUTHERN RESEARCH INSTITUTE COMPANY)

Add: 2000 Ninth Ave., South Birmingham, AL 35216 Tel: (205) 581-2247 Fax: (205) 581-2044 President: Jon McGarity

2543

SEROTEC, LTD.

Add: Endeavour House, Langford Lane, Kidlington, OX5 1GE, U.K. Tel: (44) 186-585-2700 Fax: (44) 186-585-2739 E-mail: [email protected] Web site: www.abdserotec.com President: E. Bernard Research director: A. Lane R&D expertise: Cell and tissue culture research, high quality antibodies and immunological reagents development and production. Key license and trade contracts: Inhibin. Joint ventures: Oxford Bio-Innovations.

R&D expertise: Preclinical research/development of drug for cancer therapies, infectious disease, safety assessment and pharmaceutical formulations. Technological expertise: Q, aB, c/TC, aF, gT, dD, hTDS Principal products/instrumentation: Biologicals, specialty chemicals, clinical tests, contract manufacturing products, in vitro toxicology testing, pharmaceuticals, vaccines. Main products/instrumentation under R&D: Therapeutics for cancer and infectious disease. Subsidiary bodies: Southern Research InstFrederick, 431 Aviation Way, Frederick, MD 21701; Tel: (301) 694-3232; (301) 694-7223; Engineering Research Center, 757 Tom Martin

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Drive, Birmingham, AL 35211; Southern Research Institute-Huntsville, 9238 Hwy 20 West, Building 2, Ste. 112, Madison, AL, 35758; Southern Research Institute-RTF, P.O. Box 13825 Research Triangle Park, NC 277093825; Power Systems Development Facility, P.O. Box 1069, Hwy 25 North, Wilsonville, AL 35186; 431 Aviation Way, Frederick, MD 21701, Tel: (301) 694-3232, Fax: (301) 6947223.

2545

SERVICOR, INC.

Technological expertise: BME Principal products/instrumentation: Thinwall tubes, Polyclear; Ultracentrifuge tubes, Easy-seal; Ultracentrifuge tubes, Reseal; Wettable thin wall tubes, UltraCote. Sealed and granted patents: Easy-seal, Re-seal.

2547

SETRA SYSTEMS, INC.

Add: 159 Swanson Rd. Boxborough, MA 01719-1304

Add: Seth Gladstone, National Sales Manager, San Carlos, CA, Silicon Valley

Tel: (978) 263-1400

Tel: (650) 591-5523

E-mail: [email protected]

Fax: (650) 591-3121

Web site: www.setra.com

E-mail: [email protected]

President: D. K. Li

Web site: www.servicor.com

R&D expertise: Research and production of pressure transducers.

President/CEO: Richard R. Bona R&D expertise: Manufacture and marketing of cleanrooms and clean enclosure systems. Technological expertise: BME Principal products/instrumentation: Softwall cleanrooms, Fastwall® enclosure systems, clean enclosure systems, Hepastation™ laminar flow workstation, Servicart™ mobile microenvironment. Sealed and granted patents: Fastwall™.

2546

SETON SCIENTIFIC

Fax: (978) 264-0292

Technological expertise: BME Principal products/instrumentation: Pressure transducers, transmitters, transductant, digital monometers, digital displays, digital imaging microscope.

2548

SEVERN BIOTECH, LTD.

Add: Unit 2 Park Lane Kidderminster, Worcester DY116 TJ U.K. Tel: (44) 156-282-5286 Fax: (44) 156-282-5284

Add: P.O. Box 33064 Los Gatos, CA 95031

E-mail: [email protected]

Tel: (408) 543-2134

Web site: www.severnbiotech.com

Fax: (408) 353-8019

President: Andrew Smart

Web site: www.setonscientific.com

Research director: N. Huckisson

President: Steven T. Nielsen

R&D expertise: Development of electrophoresis, manufacture of reagents, DNA purification kits, DNA and peptide synthesis and polyclonal antibodies.

R&D expertise: Manufacture and marketing of ultracentrifuge tubes, bottles and sealing systems.

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Technological expertise: PA, PIS, P/S, Q, SMC, SY, PS, PI, PS/AP

Tel: (973) 575-5252

Principal products/instrumentation: Contract manufacturing products, Human Genome Project, reagents, acrylamide solutions, Design AGEL, buffer solutions, crystal buffers, Sequencing GELS, Super Sequencer.

E-mail: [email protected]

Main products/instrumentation under R&D: DNA purification kits, DNA & peptide synthesizer, polyclonal antibodies.

2549

SGS DNA AB

Add: Jarnvagsgatan 11 Koping 731 22 Sweden Tel: (46) 221-296-500 Fax: (46) 221-296-699 E-mail: [email protected]

799

Fax: (973) 575- 5278 Web site: www.us.sgs.com Subsidiary of SGS. R&D expertise: Independent testing laboratory research of pharmaceuticals/biopharmaceuticals, related novel products manufacture. Technological expertise: E, AF, CB, C/TC, COC Principal products/instrumentation: Agriculture, biologicals, biomaterials, specialty chemicals, contract research/clinical trial products, cosmetics, detergents, diagnostics, in vitro toxicology testing methods, minerals, natural products, nutraceuticals, pesticides, pharmaceuticals, plastics.

Web site: www.sgsdna.com CEO: Sune Kvist, Ph.D. Research director: Suae Kvist, Ph.D. R&D expertise: Development and production of diagnostic and pharmaceutical grades of synthetic DNA, Technological expertise: P/S, AB, GA, GT, RD, SY

2551

SHAFIT BIOLOGICAL LABORATORIES

Add: Kibbutz Shefayim 60990 Israel Tel: (972) 9-952-3401/2 Fax: (972) 9-954-8176

Principal products/instrumentation: Diagnostic and pharmaceutical grade DNA, contract manufacturing products, diagnostics, human genome project, biopharmaceuticals products, extremely pure custom designed synthetic DNA required by the diagnostic and pharmaceutical sectors, full GMP-documentation provided with the products.

E-mail: [email protected]

Main products/instrumentation under R&D: Combinatorial chemistry, drug delivery technology, combinatorial antibody library, combined vaccines.

Joint ventures: Rahan Meristem (Kibbutz Rosh Hanikra) and University of Jerusalem.

2550

SGS US TESTING COMPANY, INC.

Add: 291 Fairfield Ave. Fairfield, NJ 07004

Web site: www.shafit.co.il President: Halm Streifler Research director: Dr. Yehuda Samberg R&D expertise: Development and manufacture of biotechnology medicines and in focus on vaccines.

R&D collaboration: Research and development of recombinant vaccines of plants with Argentina, Peru, Republic Dominican, Bolivia, P. R. China, the Philippines, Taiwan, South Korea, Myanmar, Thailand, Venezuela, Ecuador, Eastern Europe, Cyprus, African countries. Technological expertise: BA

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Principal products/instrumentation: Agriculture, biologicals, poultry vaccines, recombinant vaccines of plants. Main products/instrumentation under R&D: New infectious bronchitis-live vaccine (origin: kidney and respiratory system), clinical field tests; IBH vaccine for treatment of inclusion body hepatitis; Four Reo — Inactivated new vaccine (four serotypes); ORT (Ornithobacterium Rhinotracheale) Inactivated vaccine contains serotypes A-B-C, multicomponent vaccines, polyvalent vaccines, respiratory disease vaccines.

2552

SHAMAN PHARMACEUTICALS, INC.

Tel: (86) 635-326-2315 Fax: (86) 635-326-0786 E-mail: [email protected] Web site: www. dongeejiao.com President: Qin Yufeng Subsidiary of China Resources Medications Group Limited. R&D expertise: R&D and manufacture of special TCMM. Technological expertise: TCMM, HNT Principal products/instrumentation: Fufang E Jiao syrup, Dong E E Jiao for enriching the blood, nourishing yin, moistening and hemostasis, used in palpitation and dizziness due to deficiency of blood, vexation and insomnia.

Add: 213 E. Grand Ave. So. San Francisco, CA 94080 Tel: (415) 952-7070 Fax: (415) 873-8367 E-mail: [email protected]

2554

SHANGHAI HAO YUAN BIOTECH CO.

President/CEO: Lisa A. Conte

Add: 1998 Xin Jin Qiao Rd. Pudong, Shanghai 201206, P. R. China

Research director: Michael Tempesta

Tel: (86) 21-5899-8055

R&D expertise: Development and production of pharmaceuticals from medicinal tropical plants.

Fax: (86) 21-5899-2340

R&D collaboration: Merck, Eli Lilly. Key sales market contracts: Inverni della Beffa. Technological expertise: P/P, P/S, OC, O-C Main products/instrumentation under R&D: Vrrend™ antiviral, tropical herpes simplex virus (Phase II-III); Provir ™ antiviral, oral for respiratory syncytial virus RSV (Phase III); virucide, antiviral antibody complex.

2553

SHANDONG DONG E E JIAO CO., LTD.

Add: NO. 78, E Jiao road, Dong E county, Shandong 252201, P. R. China

E-mail: [email protected] Web site: www.en.haoyuansh.cn. President: Dao Pei Huang R&D expertise: Manufacture of nucleic acidbased test for clinical use. Joint ventures: Shangai Jin Qiao Group Co. Technological expertise: RD, GA, P/S Principal products/instrumentation: HBV Quantitative PCR Kit in Chinese market, HBVQ, 2000. Main products/instrumentation under R&D: HCV Quantitative PCR Kit; Multiple PCR for HBV, HCV and HIV. Sealed and granted patents: Beads Separator and Universal Capture in China.

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2555

SHANGHAI SANZHOU ELECTRONI SCIENCE AND TECHNOLOGY CO.

801

R&D expertise: Research, design, development, manufacture and market of medical instrument, apparatus and related software. Technological expertise: CMH, BME

Add: No. 188, Hongqiao Road, Shanghai 200030, P. R. China Tel: (86) 21-3424-1127 Fax: (86) 21-3424-6127 E-mail: [email protected] Web site: www.cnszyl.com R&D expertise: R&D, manufacture and marketing of therapeutic devices for traditional Chinese materia medica. Technological expertise: HNT, TCMM, TDI. Principal products/instrumentation: Sanzhou intelligent Chinese traditional medicine fumigation steam automatic control treatment device, the main treatment mechanism of which is the co-operating effect of 6 methods, which include medicine therapy, thermotherapy, oxygen therapy, biological electrotherapy, surge pressure and medicine massages, used for the real clinical treatment in traumatology, dermatology, obstetrics and gynecology, internal medicine, surgery, otolaryngology and cosmetology. Different Chinese traditional medicine formulas can be suitable for the treatment of many kinds of diseases, and also there is no pain or side effect during the treatment.

2556

SHANGHAI TENGYIN INDUSTRIAL CO.

Add: No. 28, 411 Lane, Shilong Road, Shanghai, P. R. China Tel: (86) 21-5411-0230 Fax: (86) 21-5408-3710 E-mail: [email protected] Web site: www. acup-equip.com.cn President: Zheng Yaoyong; Li Zheng Research director: Zhang Yulan

Principal products/instrumentation: Multimedia teaching instruments, teaching model, intelligent teaching equipment, acupuncture and massage of TCM (traditional Chinese medic) intelligent diagnostic equipment, and equipment of Chinese medicine practitioners at all levels of health masseurs’ identification and evaluation. For instance, the human body model of photoelectric sensor multimedia electronic acupuncture massage, 42′′ body acupuncture multimedia interactive digital platform, the teaching system of 19” LCD touch screen reflexology district acupuncture manipulation parameter detector, intelligent manipulation detector, intelligent pulse condition instrument for TCM, pulse condition model for TCM. Electric Ovoid-tip Needle (T03753923182, inventors Zhang Xinkuan, Zhang Bingran, Luo Yongkuan). It adds pulseelectrotherapy noninvasive needles that are based on ancient ovoid-tip needle. Because it is cooperated with movement, it is known as Electronic Ovoid-tip Needle Kinesitherapy. Electric pulse works as a pain-killer and is also anti-inflammatory. The ovoid-tip needle can peel off conglutination. Kinesitherapy prompts the replacement of joint’s micro-displacement. The union of the electric pulse, the ovoid-tip needle and the Kinesitherapy can make the efficacy prominent through clinical practice, especially to cervical spondylosis, periarthritis of shoulder, lumber hyperosterogeny, knee joint hyperosterogeny and various sorts of soft tissue disease. Acupuncture experts in China identify that the therapy is based on abundant theory and novel approach. The electronic ovoid-tip needle originates in China — it is very practical, and advances the development of acupuncture therapy. Main products/instrumentation under R&D: TCM Therapists-Acupuncture and Massage

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Therapy System — it integrates software with hardware and accords to control in real time. The system also maintains medical records, analyzes therapeutic efficiency, gives feedback information and instructs treatment. TCM Diagnosis History-Remote Support and Analysis System — it contains the tongue and pulse diagnosis teaching equipments’ software development to fulfill every aspects of a “Teaching-Clinic”.

2557

SHARED SYSTEMS, INC.

Research director: M. Bentley R&D expertise: Development and production of poly ( ethylene glycol) derivatives for pharmaceutical use, primarily protein conjugation. Technological expertise: DD, SY Principal products/instrumentation: Biomaterials, chemicals, contract manufacturing, pharmaceuticals, Poly(ethyiene glycol) and derivatives for pharmaceutical and biotech applications. Main products/instrumentation under R&D: Drug delivery PEG products.

Add: P.O. Box 408, Sewell, NJ 08080 Tel: (856) 218-7900

2559

Fax: (706) 855-6588 E-mail: [email protected]

SHELDON MANUFACTURING, INC.

Web site: www.sstinc.net

Add: 300 North 26th Ave. Cornelius, OR 97113

President/CEO: Robert C. Hicks

Tel: (503) 640-3000

Research director: T. S. Knox

Fax: (503) 640-1366

: Immunology and microbiology; novel products development and manufacture.

E-mail: [email protected]

Key sales market contracts: Seradyn Inc., Procter & Gamble, Reference Diagnostics, Inc.

President: George Sheldon

Key license and trade contracts: Reference Diagnostics, Inc. Technological expertise: BA, P/S Principal products/instrumentation: Mycoplasma.

2558

SHEARWATER POLYMERS, INC.

Add: 1112 Church St. NW Huntsville AL 35801-5914

Web site: www.shellab.com R&D expertise: Development and manufacture of constant temperature equipment for labs. Technological expertise: F, TE, C/TC, COC, GT, RD, HTDS, PMC Principal products/instrumentation: CO2 incubators and general purpose incubators; Shakers, incubators; Water Baths and Reciprocating Water Baths; Ovens. Sealed and granted patents: Copper Housing in HEPA filter in CO2 incubator.

Tel: (256) 533 4201 Fax: (256) 533-4805 E-mail: [email protected] Web site: www.shearwater.com President/CEO: J. Milton Harris

2560

SHIMADZU SCIENTIFIC INSTRUMENTS

Add: 7102 Riverwood Dr. Columbia, MD 21046

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Tel: (410) 381-1227 Fax: (410) 381-1222 E-mail: [email protected]

803

preclinical; Butyrylcholinesterase Inj., preclinical; Calcitonin CD, preclinical; Glipizide CR, preclinical; GMRH Agonist, preclinical.

Web site: www.ssi.shimadzu.com President: Shingo Takimoto

2562

Subsidiary of Shimadzu Kyoto. R&D expertise: R&D of bioprocess engineering, and scientific instruments, novel products manufacture. Technological expertise: COC, CH/S, PIS, SY, P/S, BME Principal products/instrumentation: Biological separations by HPLC, chromatography; Spectroscopy; Shim-pack XR Series of HPLC columns, 2007; AXIMA-TOF2™ MALDI TOF-TOF mass spectrometer, a high-energy, collision-induced dissociation (CID) MS/MS instrumentation, 2007.

2561

SHIRE LABORATORIES, INC.

Add: 1550 East Gude Dr. Rockville, MD 20850 Tel: (301) 838-2500 Fax: (301) 838.-2501 President/CEO: Jack A. Khattar Research director: Richard A Couch, Ph.D. Subsidiary of Shire Pharmaceuticals Group Plc. R&D expertise: R&D of advanced drug delivery. Technological expertise: C/TC, CH/S, HTDS, DD Principal products/instrumentation: Amphetamine salts, Adderall; Carbamazepine, IDURSULFASE(i-LAPRASE), 2006. Main products/instrumentation under R&D: Carbatror™, Phase III; PI III.2, Phase III; Selegiline CR, Phase I; DHE Buccal, Phase I; Nifedipine CR, preclinical; Acyclovir CD,

SHXK INTERNATIONAL INSTITUTE OF CHINESE MEDICINE

Add: 10 Huayuan Road, Haidian District, Beijing, P. R. China. Tel: (86) 10-8202-3503 Fax: (86) 10-6205-3344 E-mail: [email protected] Web site: www.e-health.net.cn R&D expertise: Research and innovation of qualitation and quantitation diagnosis for Chinese medicine, development of modernized medical examination for Chinese medicine, and related novel products manufacture. Technological expertise: TDI, TCMM Principal products/instrumentation: 4 TCMM diagnostic instruments including subillnes evaluation instruments, physical constitution and agility evaluation instruments, microscopic glossography instruments and meridian analytic/evaluation instruments for TCMM, and other TCMM diagnostic instruments.

2563

SIALOCARB CHEMICALS

Add: Villavagen 18 Eslov 241 31 Sweden Tel: (46) 413-555-527 Fax: (46) 413-555-572 E-mail: [email protected] President: Torgny Lundgren R&D expertise: Development and manufacture of biotech pharma. Technological expertise: BA, CB, C/TC, H/CF, P/S

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Principal products/instrumentation: Blood Grouping Reagents. Main products/instrumentation under R&D: Carbohydrate products for pharmaceutical research applications derived from natural sources (human milk). Sialyl oligosaccharides. Monoclonal antibodies for blood grouping applications. Monoclonal antibodies directed toward carbohydrate antigens on cell surfaces; to be used for research and cancer diagnosis.

2564

SIBIA NEUROSCIENCES, INC.

Add: 505 Coast Blvd. South, Ste. 300 La Jolla, CA 92037 Tel: (858) 452-5892

2565

SIEMENS INDUSTRIAL AUTOMATION, INC.

Add: 100 Technology Dr. Alpharetta, GA 30202 Tel: (404) 740-3000 Fax: (404) 740-3299 President/CEO: Roy Slavin Subsidiary of Siemens AG. R&D expertise: R&D and manufacture of industrial and process automation equipment Technological expertise: PMC, CH/S, AU Principal products/instrumentation: Simatic process control system, Simatic programmable controllers.

Fax: (858) 459-1609 E-mail: @sibia.com President/CEO: William T. Comer, Ph.D. Research director: Jeffrey F. McKelvy, Ph.D. R&D expertise: Discovery, design and development of novel small molecule therapeutics for the treatment of neurodegenerative, neuropsychiatric and neurological disorders. R&D collaboration: Bristol-Myers Squibb Company; Meiji Seika; Kaisha, Ltd.; Eli Lilly & Co. Key license and trade contracts: Aurora Biosciences Corp., Cognetix, Inc., The Salk Institute, Eli Lilly & Co., Merck & Co., Neurocrine Biosciences, Affymax/Glaxo Wellcome. Technological expertise: C/TC, COC, HTDS Main products/instrumentation under R&D: SIB-1508Y for Parkinson’s disease, Phase II; SIB-1553A for Alzheimer’s disease, Phase II. Sealed and granted patents: 48 issued U.S. patents, 13 allowed U.S. patents and 58 U.S. patent applications pending, as well as 26 issued for foreign patents and 71 foreign patents pending.

2566

SIERRA BIOMEDICAL SAN DIEGO, INC.

Add: 10326 Roselle St. San Diego, CA 92121 Tel: (619) 623-0888 Fax: (619) 623-0880 E-mail: [email protected] Web site: www.preclinical.com President: David C. McCaslin Research director: Kevin Braybrook, Ph.D. R&D expertise: Contract R&D in vivo preclinical testing of pharmaceuticals, biopharmaceuticals, medical devices, and animal health products. Areas of expertise, include model development, toxicology, PK/ADME, pharmacology, experimental surgery and cardiovascular studies. Facilities are AAALAC-accredited and GLP compliant. Technological expertise: AF, AB, BS, TG, SMC, DD Principal products/instrumentation: Biologicals, biomaterials, contract research/clinical trials products, organ transplants/culture, pharmaceuticals, vaccines, veterinary, nutraceuticals.

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SIERRA SEPARATIONS, INC.

Add: 56 Glen Carran Circle Sparks, NV 89431 Tel: (702) 356-5755 Fax: (702) 825-1729. President: James V. Benson Research director: James V. Benson R&D expertise: R&D and manufacture/marketing of high performance liquid chromatography products. Technological expertise: CB, P/S, SY Principal products/instrumentation: Chromatographic columns and resin packing materials for the analysis of biological materials such as organic acids, amino acids, rapid alcohols and carbohydrates. Inorganic cations and porous polymers are products for analysis for a variety of products.

805

Main products/instrumentation under R&D: Vaccines for strep throat, periodontal disease and sexually transmitted disease, preclinical; Gram-negative antibiotics, preclinical; Grampositive antibiotics, preclinical. Sealed and granted patents: Vaccine delivery system, strep throat vaccine, protein expression system for producing biopharmaceutical products.

2569

SIGMA

Add: 3506 S. Broadway Saint Louis, Missouri MO 63118 Tel: (314) 771-5765 Fax: (314) 771-5757 Web site: www.sigmaaldrich.com/united-states. html President: Dave Julien Subsidiary of Sigma- Aldrich, INC.

2568

SIGA PHARMACEUTICALS, INC.

Add: 420 Lexington Ave. Ste. 620 New York, NY 10170 Tel: (212) 672-9100 Fax: (212) 697-3130 E-mail: [email protected] Web site: www.siga.com CEO: Joshua Schein Research director: Dennis Hruby R&D expertise: Biopharmaceutical R&D focusing on the development and commercialization of mucosal vaccines and novel antiinfectives for the prevention and treatment of infectious diseases. R&D collaboration: Wyeth-Ayerst — grampositive antibiotics; National Institutes of Health — strep throat vaccine; SUNY Buffalo — periodontal disease; Chiron — vaccines for sexually transmitted disease. Technological expertise: DD, D-D

R&D expertise: Manufacturer and distributor of biochemicals and reagents for life science research; peptides and peptide instrumentation. Technological expertise: E, Q, F, CS, RD, BA, H/TC, C/TC, SY Principal products/instrumentation: Biochemicals, cell culture products, immunochemicals, molecular biology products, cell signaling products, peptide instrumentation, ACTH, angiotensin, bradykinin, CD4 fragments, CGRP, CRF, endorphin, endothelin, enkephalin, LH-RD, neurotensin, parathyroid hormone, substance P, thyrocalcitonin, vasopressin, VIP. Main products/instrumentation under R&D: Beta-amyloid fragments, sarafotoxin erythropoietinfragments.

2570

SIGMA-GENOSYS

Add: 1442 Lake Front Circle, Suite 185 The Woodlands, TX 77380-3600

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Tel: (281) 234-5362 Fax: (281) 363-5909 E-mail: [email protected] Subsidiary of Sigma-Aldrich. R&D expertise: R&D and manufacture of life science products, peptide and peptide instrumentation. Marketing agreements Cashmere, Amrad, Chem-Bio, Pharmacia-Biotech. Key license and trade contracts Baylor College of Medicine. Technological expertise: PI, PA, AB, CS, P, PIS, SY Principal products/instrumentation: Products of custom Oligo synthesis, custom peptide synthesis, and custom gene synthesis, DNA isolator, RNA isolator, E-link, multi-E-link, oligo/plate, vectorette II, GeneScout, SPOTs.

Key sales market contracts: Hoffmann-La Roche, SmithKline Beecham, Alcar investigational Alzheimer’s drug. Technological expertise: D-D, CSDP Principal products/instrumentation: Levocamitine (Camitor®) treatment for a series of metabolic disorders associated with carnitine deficiency; acetyl-L-carnirine (Alcar®) investigational drug for treatment of Alzheimer’s disease; propionyl-L-camitine for treatment of several cardiovascular conditions. Main products/instrumentation under R&D: Novel under R&D; novel biopharmaceuticals, biotechware.

2572

SIGNALGENE, INC.

Subsidiary bodies: Genosys Biotechnologies (Europe) Ltd., London Road, Pampisford, Cambridge, CB2 4EF, U.K., Tel: (44) 12-23839000, Fax: (44) 12-2383-9200, E-mail: [email protected], Contact: Richard Andrews.

Add: 8475 Christophe-Colomb Ave. Ste. 1000 Montreal, PQ H2M 2N9 Canada

Sealed and granted patents: Segmented Synthesis, Biotin-phosphoramidite.

Web site: www.signalgene.com

Tel: (514) 850-2400 Fax: (514) 850-2424 E-mail: [email protected] President/CEO: Dr. Michael Dennis Research director: Dr. Lawrence T. Malek

2571

SIGMA-TAU PHARMACEUTICALS, INC.

Add: Sigma-Tau Pharmaceuticals, Inc.9841 Washingtonian Blvd. Suite 500 Gaithersburg, MD 20878 Tel: (301) 948-1041 Fax: (301) 948-1862 E-mail: [email protected] Web site: www.sigmatau.com President: Claudio Cavazza, Ph.D. Research director: Dr. Antonio Amato Subsidiary of Sigma-Tau S.P. R&D expertise: R&D and production of pharmaceuticals/biopharmaceuticals.

R&D expertise: Genomics research, focused on identifying disease-associated genes and validating drug targets that enable the development of genomic-based diagnoses and the discovery of novel drug candidates for major human disorders, combination of access to unique population and world-class scientific collaborators, its integrated technology platform and its growing portfolio of proprietary disease-associated genes and drug targets. A pharmacogenomics service targeting the CROs and their sponsors and expanding its discovery services to include gene discovery and target validation as well as lead compound generation. R&D collaboration: An agreement with Dr. Bernard Delisle, Quebec City, for psoriasis; 2 agreements with Centre Hosptialier

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Universitaire de Quebec (CHUQ): 1 for osteoporosis and breast cancer and 1 for osteoporosis; an agreement with McGill University Health Centre for obesity and diabetes; collaboration agreement with the National Research Council of Canada for neurodegenerative disorders; research alliance with St Justine Hospital in pharmacogenomics.

Web site: www.signalpharm.com

Key license and trade contracts: Genset SA (France) for Alzheimer’s disease.

R&D collaboration: DuPont, Ares Serone, Axys.

Technological expertise: Q, BI, GA, G, PIS, PG

Technological expertise: HI, SMC, HTDS

Principal products/instrumentation: Genetic analyses; functional genomics; functional proteomics; bioinformatics; drug design technologies. Main products/instrumentation under R&D: Identifying disease-associated genes, discovery of novel drug candidate for major human disorders, estrogen receptor genes. Subsidiary bodies: Nanodesign, INC., Research Park Center, 150 Research lane, Suite 300, Guelph, ON, NIG 4T2, Canada, Web site: www.nanodesign.com. Sealed and granted patents: Subtractive Amplification (U.S.); Marker at the Estrogen Receptor Gene for Determination of Osteoporosis Predisposition (U.S.); Evolutionary Molecular Design (U.S.). Over 13 pending patents covering functional genomics technologies, genetic diagnostics and/or drug targets for therapeutics.

2573

SIGNAL PHARMACEUTICALS, INC.

Add: 4550 Towne Centre Court, San Diego, CA 92121 Tel: (858) 558-7500 Fax: (858) 552-8775 E-mail: [email protected]; [email protected]

President/CEO: Alan J. Lewis, Ph.D. Research director: David W. Anderson, Ph.D. R&D expertise: R&D of Intracellular Signaling and Transcriptional Activation in inflammation, virology, bone disease and CNS disease; novel products manufacture.

Main products/instrumentation under R&D: Oncoprotein kinase, AP-l activation blockers, preclinical; NFkB activation blockers, preclincal; CEBP/B activation blockers, preclinical; HPV inhibitors, preclinical; CMV inhibitors, preclinical; HCV inhibitors, preclinical; HSV inhibitors, preclinical. Sealed and granted patents: Oncoprotein Protein Kinase and JNK; compounds and methods for modulating activation of NF-kappa B, 20070208167 U.S.

2574

SIGNALSITE, INC.

Add: 216 Jaffa Rd. Jerusalem 94383 Israel Tel: (972) 2-537-4997 Fax: (972) 2-537-5098 CEO: Dr. Yoni Bamhard R&D expertise: R&D of platform technology for rational drug design. R&D collaboration: Hebrew University, Jerusalem; Scientific collaborations: Children’s Hospital, Boston (Dr. J. Folkman); University of Uppsula, Sweden (Dr. L. WelshClaesson). Technological expertise: D-D, P, PIS, PS, PS/AP, P/PS Main products/instrumentation under R&D: Small peptides for modulation of signal transduction in an array of medical illnesses (cancer, diabetes, autoimmunity, obesity), preclinical;

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platform technology for rational drug design, short peptides for selectively modulate intracellular signaling. Sealed and granted patents: Short peptides which selectively modulate intracellular signaling, filed in 1997; short peptides which selectively modulate the activity of serine/ threonine kinases, filed in 1997.

2575

SIGNAL TRANSDUCTION PRODUCTS-STI

Add: 920-A Calle Negocio, San Clemente, CA 92673 Tel: (949) 492-8298; (800) 772-1776 Fax: (949) 492-6790 E-mail: [email protected] Web site: www.americanqualex.com; http: //iqualex.com/

Research director: Iqbal W. Siddiqi, Ph.D. R&D expertise: Biomagnetic process development and automation research; manufacture of automated magnetic separation instruments. R&D collaboration: Switzerland.

Debiotech

S. A.

Technological expertise: TE, BA, GT, P/S, R Principal products/instrumentation: “MKSEP” automated biomagnetic mixing and separation instruments;Purification System: SieNA is a modular, robotic, magnetic purification system for sample prep needs in molecular diagnostics and clinical microbiology. The stand-alone system combines a magnetic processor, sample barcode reader, and a servocontrolled robotic arm to automate any pipetting protocol. 2009.

President: Daniel Moothart

Main products/instrumentation under R&D: Biomagnetic stem cell isolation device, automated magnetic separation instruments.

Research director: Laurie Stephen, Ph.D.

Sealed and granted patents: 2 patents held.

R&D expertise: Development and manufacture of immunological reagents. Technological expertise: PA, Q, C/TC, H/CF, PIS Principal products/instrumentation: Conjugated secondary antibodies; biotonylation kits; FITC labeling kit. Main products/instrumentation under R&D: Monoclonal antibodies to frequenin, culmodolin, and immunological reagents.

2577

SILK SCIENTIFIC, INC.

Add: P.O. Box 533 Orem, Utah 84059 Tel: (801) 377-6978 Fax: (801) 228-2448 E-mail: [email protected] Web site: www.silkscientific.com President/CEO: Jeff Silk Research director: Jeff Elliott

2576

SIGRIS RESEARCH, INC.

Add: 2841 Saturn Street, Unit A Brea, CA 92821 Tel: (714) 528-8004 Fax: (714) 528-6207 Web site: www.sigris.com President: Iqbal W. Siddiqi, Ph.D.

R&D expertise: R&D and production of biotechnology software. Technological expertise: Q, CH/S Principal products/instrumentation: UNSCAN-IT gel software converts a scanner into a gel densitometer. Main products/instrumentation under R&D: Novel biotechnology software.

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2578

SILVERSON MACHINES, INC.

809

President/CEO: Andre Lafond Research director: Jean-Yves Gilbert

Tel: (413) 525-4825

R&D expertise: Development and manufacture of disposable laboratory plasticwares and equipment.

Fax: (413) 525-5804

Technological expertise: BME

E-mail: [email protected]

Principal products/instrumentation: Cryovial, cryogenic tubes; Histosette, embedding cassettes; Micrewtube®, microcentrifuge tubes.

Add: 355 Chestnut St. East Longmeadow, MA 01028

Web site: www.silverson.com R&D expertise: Development, manufacture and marketing of high shear mixers for drug research. Technological expertise: BME Principal products/instrumentation: High shear mixers.

2579

SIMMLER, INC.

Add: P.O. Box 350 4564 North Square Dr. High Ridge, MO 63049 Tel: (636) 376-8347; 800-325-0786 Fax: (636) 376-8324 Web site: www.simmler.com President: T. Joyce Erb R&D expertise: Development and manufacture of kits and other biotech drugs. Technological expertise: DR, COC, E, ET Principal products/instrumentation: Fetal cell stain kit. Main products/instrumentation under R&D: Novel biotech drugs.

2580

SIMPORT PLASTICS, LTD.

Add: 2588 Bernard Pilon, Beloeil, Qc J3G 4S5 Canada Tel: (450) 464-1723 Fax: (450) 464-3394

Main products/instrumentation under R&D: Other novel equipment, disposable laboratory plasticware.

2581

SITHEAN CORPORATION

Add: 6757 N Chapultapec CirTucson, AZ 85750 Tel: (520) 615-2609 President: Nancy W. Harris Research director: Paul R. Harris, Ph.D. R&D expertise: Research of peptides and peptide instrumentation, related novel products development/manufacture. Technological expertise: CS, E, P, PI, PIS, P/PS, PS, PS/AP, scale-up, purification, distillation, cyanide chemistry, fluorine chemistry, bromine chemistry. Principal products/instrumentation: Combinatorial synthesis, custom synthesis, custom/ contract production of synthetic peptides. Main products/instrumentation under R&D: Peptide sequencer, peptide synthesizer, peptide nucleic acid, peptide hormone. Subsidiary bodies: More than 215 custom chemical manufacturers in the U.S., India, China, and U.K.

2582

SKATRON INSTRUMENTS AS

E-mail: [email protected]

Add: Dolasletta 3 P.O. Box 8 Lier 3401 Norway

Web site: www.simport.com

Tel: (47) 32-859-800

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Fax: (47) 32-859-801 President: Helge Skare Subsidiary of Molecular Devices, INC., CA, U.S.A. R&D expertise: Development, design, production and marketing of instrumentation for laboratories, with focus on liquid handling instruments. Technological expertise: C/TC, HTDS, BME Principal products/instrumentation: In vitro toxicology testing, cell harvesting equipment, microplate washers-SkanWasher and SkanStacker, equipment for cytotoxicity testing — Supernatant Collection System, Imbla microplate washer for 384 well plates. Main products/instrumentation under R&D: Liquid handling instruments. Subsidiary bodies: U.S.A.

2583

SKINETHIC LABORATORIES

Add: 45, rue Saint-Philippe-06000 Nice, France Tel: (33) 4-9397-7727

Main products/instrumentation under R&D: Other types of mucosa, reconstituted human epidermis. Subsidiary bodies: 15 Rue Herold, 06000 Nice, France.

2584

SKW CHEMICALS, INC.

Add: 1509 Johnson Ferry Rd., Ste. 150 Marietta, GA 30062 Tel: (770) 971-1317 Fax: (770) 971-4306 E-mail: [email protected] President: Alan Mick Research director: Dr. Hans-Georg Erben R&D expertise: R&D and manufacture of pharmaceutical, agrochemical and biochemical intermediates. Technological expertise: SMC, SY Principal products/instrumentation: Cyanamid and derivatives, Guanidine Hydrochloride, PMSF, Kaminski reagent, Guanylation reagents; Guanidine Thiocyanate.

E-mail: [email protected]

Main products/instrumentation under R&D: Key biochemical intermediates for several products in various stages of clinical trials.

Web site: www.skinethic.com.

Subsidiary bodies: Trostberg, Germany.

Fax: (33) 4-9397-7728

President: Martin Rosdy R&D expertise: Research and production of reconstituted human epidermis and in vitro testing thereon.

2585

SKYPHARMA, INC.

Technological expertise: TE, C/TC, DD, HTDS

Add: 10450 Science Center Dr. San Diego, CA 92121

Principal products/instrumentation: Contract research/clinical trial product, in vitro toxicology testing method, reconstituted human epidermis; Skinethic®, in vitro toxicology testing, cutaneous irritation protection- pharmacological activities; reconstituted human cornea; reconstituted human tissues.

Tel: (858) 625-2424 Fax: (858) 625-2439 E-mail: [email protected] Web site: www.slcyepharma.com President: John P. Longenecker, Ph.D. Research director: Randy Willis, Ph.D.

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R&D expertise: R&D and production/marketing of DepoFoam sustained-release formulations of injectable pharmaceutical products. R&D collaboration: Amgen, Pfizer

Chiron;

DepoCyt;

Key sales market contracts: Chiron. Key license and trade contracts: Chiron. Technological expertise: DD, P/PS, PPAT, RPP Principal products/instrumentation: DepoCyt™, DepoAmikacin™, DepoMorphine™, DepoCyt approved, U.S. and Canada. Main products/instrumentation under R&D: DepoMorphine in Phase I clinical trials, DepoAmikacin, completed Phase I; DepoMorphine, completed Phase II; Depo/Therapeutic protein, preclinical testing. Sealed and granted patents: Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride.

811

lymphoma, AIDS-related lymphoma, microsporidiosis, lymphoma, prostate cancer, polyamine analogs, naphthoquinone derivatives, porphyrins, anti-cancer, antiparastitic, human cancer cell lines (MTT assays), leukemia, lung cancer, breast cancer, brain cancer, colon cancer. Sealed and granted patents: #5,580,715; #5,639,600; # 5,744,122; #5,541,230; #5,763,625; #5,824,700; #5,883,270; #5,889,061.

2587

SMITH COMPANIES TECH PRODUCTS

Add: 4368 Enterprise St. Fremont, CA 945386305 Tel: (510) 490-8999 Fax: (510) 659-1855 E-mail: [email protected] Web site: www.smithdental.com President: Holly Bell Walter Research director: Barry J. Walter

2586

SLIL BIOMEDICAL CORP.

Add: P.O. Box 6531 Monona, WI 53716-6531

R&D expertise: Development and production of medical and dental products, including a multiple syringe drive.

Tel: (608) 819-1126

Technological expertise: Q, CH/S

E-mail: [email protected]

Principal products/instrumentation: Contract manufacturing products, dental film scanner, Multiple Syringe Drive/Actuator.

Web site: www.slil.com President/CEO: Peter Molloy Research director: Dr. Laurence Malton R&D expertise: R&D and design of small synthetic therapeutic compounds to treat cancer, neurological and infectious diseases, with a focus on the role of macrophages in disease. Technological expertise: Q, C/TC, D-D, GA, PG, RD, SMC, SY Main products/instrumentation under R&D: 16 lead compounds with focus on small synthetic therapeutic compounds, 5 are candidate drugs, 1 compound is to be filed for an IND, a potential drug ready to treat AIDS related

Main products/instrumentation under R&D: Novel medical and dental products. Sealed and granted patents: #5,567,122.

2588

SMITHKLINE BEECHAM BIOPHARMACEUTICALS

Add: 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406 Tel: (610) 239-3887 Fax: (610) 239-3883

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E-mail: [email protected]

2590

SOIL TECHNOLOGIES CORP.

Web site: www.gsk.com President: Don Bergmann, General Manager

Add: 2103 185th St. Fairfield, IA 52556

Subsidiary of SmithKline Beecham, PLC

Tel: (641) 472-3963

R&D expertise: Biopharmaceutical development and manufacturing.

Fax: (641) 472-6189

Technological expertise: C/TC

Web site: www.soiltechcorp.com

Principal products/instrumentation: LYErix™ Lyme disease vaccine (recombinant OspA) contract manufacturing, vaccines, antibodies, reagents, peptides, other biopharmaceutical.

President: Jim Schaefer

Main products/instrumentation under R&D: DTP/hepatitis B/inactivated polio vaccine to treat diphtheria, tetanus, pertussis, hepatitis B and polio prevention, application submitted; LYMErix lyme disease vaccine (recombinant) for lyme disease prevention (pediatric use), Phase III/IV; malaria vaccine for malaria prevention, Phase III/IV; MMR-Varicella for chicken pox prevention, Phase III/IV.

2589

SNAMPROGETTI BIOTECNOLOGIE S.P.A.

Add: Viale De Gasperi 16 San Donato Milanese 20097 Italy Tel: (39) 2-5205-2666 Fax: (39) 2-5205-2690 E-mail: [email protected] President/CEO: Enrico Bardone R&D expertise: Design and construction of plants technology, pharmaceuticals, agro and food feasibility studies. Technological expertise: F, RD, P/S, C/TC, PMC Principal products/instrumentation: Scalingup, processing and engineering services. Main products/instrumentation under R&D: Mobile pilot plants. Sealed and granted patents: Mobile pilot plant

E-mail: [email protected]

R&D expertise: Development and production/ marketing of biopesticides, beneficial microbes, biofertilizers, soil conditioners — all for agricultural applications. Joint ventures: Japan Agritech Co., Ltd. — organic soybeans for Japan. R&D collaboration: Iowa Product Development Corporation — biofungicides. Key license and trade contracts: Iowa State University. Corn gluten herbicide. Technological expertise: F, AF, E, ET, ERT Principal products/instrumentation: Agriculture, bioremediation, environmental, natural products, pesticides M1CROP 4XL — cyanobacteria; Pondkleen — bacteria and enzymes for bioremediation; BacPack™ — beneficial bacteria root inoculant; DynaWeed corn gluten herbicide. Main products/instrumentation under R&D: Biofungicide — field trial stage, biopesticides, bioferfilizers. Sealed and granted patents: Methods for treating soils-U.S. # 4,774,186.

2591

SOLABIA GROUP

Add: 29 Rue Delizy Pantin Cedex 93698 France Tel: (33) 1-4810-1940 Fax: (33) 1-4891-1877 Web site: www.solabia.com President/CEO: G. Josset

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Research director: G. Thevenet

Tel: (781) 396-6444

R&D expertise: Development and production of peptones for fermentation and diagnostic; production of cosmetics, pharmaceuticals and culture media for diagnostic.

Fax: (781) 396-2615

Technological expertise: E, F, BA Principal products/instrumentation: Cosmetics, diagnostics, pharmaceuticals, vaccines, veterinary, drug products. Main products/instrumentation under R&D: Peptones for fermentation and diagnostic.

2592

SOL-GEL TECHNOLOGIES

Add: Weizmann Science Park 7 Golda Meir St. Ness Ziona 74036, Israel Tel: (972) 8-931-3433 Fax: (972) 8-931-3434 E-mail: [email protected]. Web site: www.sol-gel.com CEO: Dr. Alon Seri-Levy

813

E-mail: [email protected] President/CEO: Dr. Irving Sucholeiki Research director: Dr. Irving Sucholeiki R&D expertise: Materials research/development/manufacture, specializing in specialty chemical and automation tools to support drug discovery. Technological expertise: COC, CH/S, HTDS, PIS, P/S, R, SMC, SY, DDI, AU Principal products/instrumentation: Various high loading supports for solid phase organic chemistry and screening. Main products/instrumentation under R&D: Automation equipment to automate combinatorial chemistry synthesis, beta testing automation tools to support drug discovery. Subsidiary bodies: U.S. 5,858,534; U.S. 5,750,412; U.S. 5,834,121; U.S. 5,684,130; U.S. 5,835,329; U.S. 5,779,985 and other patents pending.

Research director: Dr. Noa Lapidot R&D expertise: Research and application of Sol-gel technology for the development and production of innovative healthcare products.

Add: 321 Lexington Ave. Iowa City, IA 52246

Technological expertise: DD

E-mail: [email protected]

Main products/instrumentation under R&D: Innovative encapsulated sunscreen ingredients, scale-up; sol-gel technology for the development and production of innovative healthcare products.

Web site: www.solltechnologies.com/index. html

Sealed and granted patents: U.S. 5,292,801, Doped Sol-gel glasses for obtaining chemical interactions (and follow-on patents).

R&D expertise: R&D and production/marketing of biotechnology software, computer-assisted products for analyzing DNA fingerprinting images and organisms which move and change shape over time.

2594

SOLL TECHNOLOGIES, INC.

President/CEO: Robert D. Williams Research director: David R. Soll, Ph.D.

SOLID PHASE SCIENCES CORPORATION

R&D collaboration: University of Iowa, Biology Department

Add: 550 Boston Ave. 2nd Flr. Medford, MA 02155

Key sales market contracts: Alsbyte Biotechnologies, BioVision, AAD Trading Group, IEDA Trading Corp.

2593

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Key license and trade contracts: University of Iowa. Technological expertise: CH/S, BTS, DK, AMS Principal products/instrumentation: DIAS (Dynamic Image Analysis System); MicroStepZ3D, DIAS (cell motility and dynamic morphology) — over 30 parameters of motility and time based morphology; DENDRON (DNA fingerprinting) — includes patented analytical tools for the correction and comparison DNA fingerprinting gel images. Main products/instrumentation under R&D: 3D-DIAS (Dynamic Image Analysis System), biotechnology software. Sealed and granted patents: DIAS, 1997 Dynamic Image Analysis System; Dendron, 1995.

2595

SOLMAR CORP.

Add: P.O. Box 2329 Carlsbad, CA 92018 Tel: (760) 734-1685 Fax: (760) 734-1778 E-mail: [email protected] Web site: www.solmarcorp.net President: R. B. Grubbs Research director: D.B. Boylan, Ph.D. R&D expertise: R&D and production formulation of bacterial consortia for environmental purposes. Technological expertise: F, ET, E, ERT Principal products/instrumentation: Advanced Bio Cultures; Bioremediation, Solmar bioincubator. Main products/instrumentation under R&D: Formulation of bacterial consortia for environmental purposes.

2596

SOLOHILL ENGINEERING, INC.

Add: 4370 Varsity Drive, Suite B Ann Arbor, Michigan MI 48108

Tel: (734) 973-2956; Fax: (734) 973-3029 Web site: www.solohill.com President/CEO: David E. Solomon Research director: William J. Hillegas, Ph.D. R&D expertise: Manufacture and marketing of microcarrier beads and related products. Technological expertise: TE, P, PI, PIS, PPAT, PS, P/PS Principal products/instrumentation: Collagen-coated microcarrier beads; glass-coated microcarrier beads; recombinant proteincoated microcarrier beads, non-blinding filters for bioreactors. Main products/instrumentation under R&D: Synthetic peptide-coated microcarrier beads. Sealed and granted patents: #4, 994,388; #5,114, 955; other patents are pending.

2597

SOLOMON PARK RESEARCH INSTITUTE

Add: 12815 NE 124th St. Suite L.Kirkland, WA 98034 Tel: (425) 650-2020 Fax: (425) 650-2028 E-mail: [email protected] Web site: www.solomon.org/index.html President/CEO: Patric A. Clapshaw, PhD. Research director: Patric A. Clapshaw, Ph.D. R&D expertise: Development and manufacture of apolipoproteins and lipoproteins. Technological expertise: E, P/S, PPAT, P/PS, RPP Principal products/instrumentation: Diagnostics, clinical tests, reagents, Proficiency survey materials for chemistry, immunology and hematology: lipoproteins (VLDL, Lp(a), LDL and HDL); apolipoproteins (AI and All).

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2598

SOLTEC VENTURES, INC.

2600

SOLVAY DRAKA, INC.

Add: P.O. Box 7074, Beverly, Massachusetts 01915

Add: 6900 Elm St. Commerce, CA 90040

Tel: (978) 922-9446

Fax: (323) 725-6466

Fax: (978) 922-1666

E-mail: [email protected]

President/CEO: Larry Evans

Web site: www.solvaydraka.com

Research director: Larry Evans

President: Fred Young

R&D expertise: Custom synthesis R&D and production of protein crosslinking reagents, biotinylating and purified detergents.

Research director: Robert Elcik

Technological expertise: CC, CB, PIS, P/S, SY, G Principal products/instrumentation: Biomaterials, contract manufacturing products, protein modification reagents, biotinylating reagents, purified detergents, derivatising reagents, Ditfiiofhreitol 99+%, Big Chaps, Deoxy Big Chaps. Main products/instrumentation under R&D: Omega 8, Omega 9, Omega 10; protein crosslinking reagents.

Tel: (323) 725-0050

R&D expertise: Raw material production and supply of medical grade films. Technological expertise: C/TC, DD Principal products/instrumentation: Biomaterials, contract manufacturing products, plastics multi-layer barrier films, PVC films, EVA films, Olefin films. Main products/instrumentation under R&D: Raw material of medical grade films. Subsidiary bodies: Europe.

2601 2599

SOLUTION 2000 WATER PURIFICATION SYSTEMS

Add: 8 Old Burnt Mountain Rd. Jasper, GA 30143 Tel: (706) 458-2021 Fax: (706) 692-9203 E-mail: [email protected] R&D expertise: Manufacturing and marketing of laboratory reagent grade water purification systems.

815

SOLVO BIOTECHNOLOGY

Add: Central Hungarian Innovations Center H-2040 Budaörs, Gyár u. 2., Hungary Tel: (36) 23-503-940 Fax: (36) 23-503-941 E-mail: [email protected] Web site: www.solvo.hu President/CEO: Erno Duda Research director: Dr. Zoltan Nagy

Technological expertise: P/S, P/S

R&D expertise: R&D of biotechnology medicines. Primary business; Service Company.

Principal products/instrumentation: Solution 2000 water purification systems.

Technological expertise: SMC, HTDS, C/TC, D-D

Main products/instrumentation under R&D: Laboratory reagents grade water purification systems.

Principal products/instrumentation: Fransfectant human/mammalian cell lines, membrane transporter protein.

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Main products/instrumentation under R&D: Reversin, preclinical; Rever-cyclins, preclinical; C Kit for determining multidrug resistance of tumor cells; Chemosensitizer for membrane transporter MRP1, MRP2, BCRP (reversins). Sealed and granted patents: Assay and reagent kit for the quantitative in vitro determination in biological specimens of the activity of proteins causing multidrug resistance in tumors. Hungarian patent application number: P 9402551, PCT/HU95/0042; Assay for multidrug resistance, U.S. letters patent application Number 5,872,014; Compounds for reversing drug resistance, Hungarian patent application number P 92 03674, PCT/IB94/00144; Functional assessment of multidrug resistance proteins and multidrug resistance associated proteins in polarized cell culture (vectorial transport assay) Hungarian patent application number: P0002557; Az MRP1 feherje funkcionalis domenj’enek szerkezetmeghatarozasa es jellemzese (Structure determination and functional characterization of the active domain of MRP1 protein) Hungarian patent application. number: P0002996.

2602

SONICS & MATERIALS, INC.

Main products/instrumentation under R&D: Cell and tissue culture, vaccines, antibodies, reagents, enzymes.

2603

SOONER SCIENTIFIC, INC.

Add: P.O. Box 180 Garvin, OK 74736 Tel: (580) 286-9408 Fax: (580) 286-7047 Web site: www.soonersci.com President/CEO: Jerry Coffey R&D expertise: R&D and manufacture/ marketing of DNA sequencing, pre-mixed gel casting solutions and electrophoresis apparatus. Technological expertise: Q, SMC, P/S Principal products/instrumentation: ® SeaQuate DNA sequencing gel solutions, DNA Sequencers, Horizontal and Vertical Electrophoresis available 0, 1mm thick gels. Main products/instrumentation under R&D: Ultrathin DNA Sequencer, Beta Testing, premixed gel casting solutions, electrophoresis apparatus.

2604

SOREBIO

Add: 53 Churchill Rd. Newtown, CT 064701614

Add: Bordeaux Technopolis Martiliac 33650 France

Tel: (203) 270-4600

Tel: (33) 557-960-960

Fax: (203) 798-4610

Fax: (33) 556-649-956

E-mail: [email protected]

President/CEO: Franck Latrille, Ph.D.

Web site: www.sonics.biz

Research director: Herve Broly, Ph.D.

President: Robert Soloff

Subsidiary of Ares-Serono.

R&D expertise: R&D and production of cell and tissue culture and other biotechnology medicines products. Technological expertise: C/TC, BS, DK, BP

R&D expertise: Development and production of bioprocess engineering products, cell culturederived biologicals biopharmaceuticals, cell and tissue culture.

Principal products/instrumentation: VibraCell, Ultrasonic Liquid Processor.

Technological expertise: F, C/TC, LP, RD, P/S, H/CF

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Principal products/instrumentation: Biologicals, vaccines, monoclonal antibodies, contract production and a full-service package for marketing authorization; commercial scale-up production and purification under current GMP. Main products/instrumentation under R&D: Cell culture-derived biologicals, cell and tissue culture, other biopharmaceuticals.

2605

SOURCE BIOPHARMACEUTICALS

Add: 5383 Westridge Dr. Boulder, CO 80301 Tel: (303) 516-1030 Fax: (303) 516-1010 E-mail: [email protected] President: Michael P. Bevilacqua, M.D., Ph.D. Research director: James Rizzi, Ph.D./Steven Hamilton, Ph.D. R&D expertise: Second-stage drug development, and target selection, product generation and therapeutic validation, for genomics and pharmaceutical companies. Technological expertise: Q, BI, COC, CH/SD-D, HTDS, PG, R, SMC, SY Principal products/instrumentation: Contract R&D drug products. Main products/instrumentation under R&D: Drug target selection.

817

Research director: William E. Gathings, Ph.D. R&D expertise: R&D and production of immunochemicals for research use in cell biology and immunology. Key sales market contracts: Fisher Scientific. Technological expertise: P/S, BA, H/CF, C/TC Principal products/instrumentation: Collagen and anti-collagen antibodies, unlabeled affinity purified antibodies and F(ab’)2 fragments, fluorochrome labeled antibodies and F(ab’)2 fragments, enzyme labeled antibodies and F(ab’)2 fragments, biotin labeled antibodies and avidin reagents, reagents for mouse immunology, monoclonal antibodies, flow cytometry reagents for human, cat and chicken cell surface antigens. Main products/instrumentation under R&D: CAM antibodies, Spectral Red reagents for three-color flow cytometry, immunochemicals for cell biology and immunology research.

2607

SOUTHERN CROP PROTECTION & FOOD RESEARCH CENTRE

Add: 1391 Sandford St. London, Ontario N5V 4T3 Canada Tel: (519) 457-1470 Fax: (519) 457-3997 E-mail: [email protected] President: Dr. Frank Marks

2606

SOUTHERNBIOTECH

Add: 160A Oxmoor Blvd. Birmingham, AL 35209 Tel: (205) 945-1774 Fax: (205) 945-8768 E-mail: [email protected] Web site: www.southernbiotech.com President: William E. Gathings, Ph.D.

R&D expertise: Development and application of alternative and environmentally acceptable technologies for the protection of vegetables, tree fruits, and field crops from disease and insect pests; determination of the impacts of agricultural practices on soil and water quality, developing alternative crops and sustainable management practices for coarse-textured soils; integrating food quality improvement into sustainable production practices.

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Principal products/instrumentation: Contract R&D products, alternative and environmentally acceptable technologies for the protection of crops.

2608

SOUTHERN RESEARCH INSTITUTE

pesticides, biopharmaceuticals, laboratory analytical equipment. Main products/instrumentation under R&D: Analyzer for laboratory research drug concentration, analytical chromatograph.

2610

Add: 431 Aviation Way Frederick, MD 21701

SOUTHLAND CRYOGENICS, INC.

Tel: (301) 694-3232

Add: P.O. Box 110669 Carrollton TX 75011

Web site: www.southernresearch.org/index.html

Tel: (214) 243-1311

President: Peter G. Canonico, Ph.D., Dir.

Fax: (214) 243-1370

Research director: Robert Buckheit, Jr., Ph.D.

President: M. Logan

Subsidiary of Southern Research Institute.

R&D expertise: Cryogenic dewars, piping, instrumentation and safety products for biopharmaceutical research.

R&D expertise: Contract research of biotechnology medicines, products development of field in virology and toxicology. Technological expertise: E, PA, COC, RD, DD, D-D, HTDS, H/CF, AB, C/TC Principal products/instrumentation: Contract research/clinical trial products, vaccines, antibodies, enzymes, reagents, antiviral drug.

2609

SOUTHERN TESTING & RESEARCH LABS, INC.

Add: 3809 Airport Dr. Wilson, NC 278968649

Technological expertise: TE, BA, C/TC, BME Principal products/instrumentation: Cryogenic dewars, cryogenic hose and piping, safety items. Main products/instrumentation under R&D: Biotech storage units, cryogenic purification equipment, cryogenic storage container, cryogenic separation devices.

2611

SOUTHWEST SCIENTIFIC RESOURCES

Tel: (252) 237-4175 Add: Ste. 150 Albuquerque, NM 87120

Fax: (252) 237-9341 President: Director

Kim

Baughman,

Managing

Tel: (505) 831-4923 Fax: (505) 831-2635

Research director: Tad Dean

E-mail: [email protected]

R&D expertise: Contract development of laboratory-analytical research equipment.

President: Gregory Kelly, Ph.D.

Technological expertise: SY

R&D expertise: Contract R&D item service of molecular biology for the biomedical research community, biotechnology firms and pharmaceutical industry.

Principal products/instrumentation: Agriculture, contact research trials products., cosmetics, environmental, minerals, nutraceuticals,

Research director: Susan Jones DVM, Ph.D.

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Key sales market contracts: SPEX Ltd., Watson Biotechnology. Technological expertise: CH/S, Q, SY, GA, P/S, PI, CS, RD, R Principal products/instrumentation: Contract manufacturing products, in vitro toxicology testing method, DNA Sequencing Service, Oligonucleotide Synthesis, Protein Sequencing, Amino Acid Analysis, Peptide Synthesis, Fluorogenic Oligonucleotide Probes.

2612

SPACE IMPORT-EXPORT S.R.L

819

Technological expertise: CH/S Principal products/instrumentation: Contract research/clinical trial products, vaccines, enzymes, reagents, and other biopharmaceuticals Main products/instrumentation under R&D: Clinical evaluation of drug, clinical antipsychotic trials of intervention effectiveness.

2614

SPD SCIENTIFIC PTE, LTD.

Add: 192 Pandan Loop #06-20 Pantech Industrial Complex Singapore 128381, Singapore Tel: (65) 6303-9877

Add: Via Ranzato 12 Milan 20128 Italy Tel: (39) 2-257-5377 Fax: (39) 2-257-2231 E-mail: [email protected] Web site: www.spacesrl.com President/CEO: E. Cicchetti R&D expertise: Manufacture and supply of biotech drug products. Technological expertise: C/TC, E, PA Principal products/instrumentation: Biotechnology drug products, vaccines, enzymes, cell/tissue culture. Main products/instrumentation under R&D: Biosynthesis gene clone, biotechware.

2613

SPADILLE APS

Add: Teglgårdsvej 123 DK-3050 HUMLEBÆK Region Hovedstaden, Denmark

Fax: (65) 6775-0995 E-mail: [email protected] CEO: Francis, C.H. Wong, M.D. R&D expertise: Development and supply of lab chemicals, reagents, plasticwares and equipments. Technological expertise: CC, E, F, PA, Q, TE, T, H/CF, PIS, PG, P/S, RD, AF, AB, BS, CB, C/TC, DD, D-D, GA, GT, G, SMC Principal products/instrumentation: Biologicals, biosensors, chemicals, contract manufacturing products, contract research/clinical trial products, cosmetics, diagnostics, food processing, Human Genome Project, instruments, in vitro toxicology testing, natural products, plasticware, organ transplants/culture, pesticides, pharmaceuticals, plastics, reagents, vaccines, veterinary drug products.

2615

SPECIALTY LABORATORIES, INC.

Tel: (45) 4848-4100 Fax: (45) 4848-4200 President: Bjarne Nielsen Research director: Lena Ejbye Schmidt, M.D. R&D expertise: Full service in clinical pharmaceutical research, data management and biostatistics.

Add: 27027 Tourney Road Valencia, CA 91355 Tel: (661) 421-7110 Fax: (661) 799-6634 E-mail: [email protected] Web site: www.specialtylabs.com

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President: Paul Beyer Research director: Meeta Patnaik, M.D. R&D expertise: Novel drugs research-based clinical laboratory focused on developing and performing esoteric clinical tests. Technological expertise: PA, RD, R, Q, SMC, AF, LP, BI, C/TC, CH/S, GA, G, PIS, PG, PMC Principal products/instrumentation: Contract research/clinical trial products, diagnostics. Main products/instrumentation under R&D: Esoteric clinical tests, novel drugs/researchbased clinical laboratory.

2616

SPECTRAL DIAGNOSTICS, INC.

Main products/instrumentation under R&D: Cardiac Panel ™, clinical trials; diagnostic kit for diagnostic and distinguishing pain. Sealed and granted patents: Diagnostic kit for diagnosing and distinguishing chest pain. Multiple analyte approach for measuring cardiac analytes in the diagnosis of chest pain.

2617

SPECTRANETICS CORPORATION

Add: 9965 Federal Drive Colorado Springs, CO 80921-3617 Tel: (719) 447-2000 Fax: (719) 447-2022

Add: 135-2 The West Mall Toronto, Ontario M9C 1C2 Canada

Web site: www.spectranetics.com

Tel: (416) 626-3233

Research director: Christopher Reiser

Fax: (416) 626-7383 Web site: www.spectraldx.com

R&D expertise: Manufacture and marketing of medical devices.

President: Christopher Plaxton

R&D collaboration: Orbus Medical.

Research director: Dr. Joseph Keffer

Key sales market contracts: Orbus Medical.

R&D expertise: Product research/development, commercialization and marketing of rapid, point-of-care cardiac diagnostic tests.

Key license and trade contracts: U.S. Surgical.

Joint ventures: Princeton BioMeditech, INC. R&D collaboration: British Technology Group, University of Toronto, Cardiac Gene Bank, Hoffmann-La Roche. Key sales market contracts: Astra GmbH, BM Browne, U.K., UniProm Diagnostics, Prestifarma Lda., Tamro Corporation. Technological expertise: PA, C/TC, GA, H/CF, P/S, RD, Q Principal products/instrumentation: Contract manufacturing products, contract research/clinical trial products, Cardiac STATus™ CK/MB Myoglobin Panel Test, Cardiac STATus ™ Troponin I Test (Europe, North America), Cardiac StaTus ™ Anti-Streptokinase Test (Europe).

President/CEO: Joseph A. Largey

Technological expertise: BME Principal products/instrumentation: CVX300; Excimer laser system, Catheters, Vitesse and Extreme. Main products/instrumentation under R&D: Laboratory information management system, labware, laboratory network. Sealed and granted patents: 32 in U.S.A., 3 in each of France, Germany, Italy and the Netherlands, and one in Japan.

2618

SPECTROCELL, INC.

Add: 143 Montgomery Ave. Oreland, PA 19075 Tel: (215) 572-7605 Fax: (215) 885-2792

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821

SPECTRONIC UNICAM

Web site: www.spectrocell.com President: Mike Serianni

Add: 820 Linden Ave. Rochester, NY 14625

R&D expertise: Precision glass products and spectrophotomer cells.

Tel: (716) 248-4000

Technological expertise: C/TC, BME

E-mail: info@spectronic, com

Principal products/instrumentation: Cells

Web site: www.spectronic.com

Main products/instrumentation under R&D: Spectrophotomer cell, precision glass products.

President: Robert Behrends

2619

SPECTRONICS CORP.

Fax: (716) 248-4200

Subsidiary of Thermo Optek Corp. R&D expertise: Research and production of laboratory professional equipment. Technological expertise: E, SMC, BME, RD

Add: 956 Brush Hollow Rd. P.O. Box 483 Westbury, NY 11590 Tel: (516) 333-1254 Fax: (516) 876-8411 E-mail: [email protected] Web site: www.spectroline.com President: J. D. Cooper R&D expertise: Development and manufacture of biomedical equipment/instrumentation for biopharmaceutical research. Technological expertise: Q, C/TC, GA, GT, P/S, RD Principal products/instrumentation: Spectrolinker™-UV Crosslinkers, Spectroline™ Fixed and Variable Intensity Transilluminators, Spectroline™ EVD 1000 Electronic Video Documentation System, Bi-O-Vision™ Dual Light Transilluminator, Spectroline™ Ultraviolet Viewing Systems, Spectroline™ UV Viewing Cabinets, Spectroline™ Ultraviolet Lamps, Monotec™ and Four Square® and Valve Autoradiography cassettes, L-Plus® Intensifying Screens, GeneLine ™ Gel Documentation Systems. Main products/instrumentation under R&D: Biomedical equipment/instruments for biopharmaceutical research.

Principal products/instrumentation: Spectrophorometery, spectroflourometery: SPECTRONIC GENESYS™ Spectrophotometers; FRENCH™ Press and Pressure cells; SPECTRONIC Spectrophotometers; MINI 20™ Spectrophotometer, SLM-AMINCO® Fluorescence Instruments. Main products/instrumentation under R&D: Laboratory professional equipment.

2621

SPECTRUM LABORATORIES, INC.

Add: 18617 Broadwick St. Rancho Dominquez, CA 90220 Tel: (310) 885-4600 Fax: (310) 885-4666 E-mail: [email protected] Web site: www.spectrapor.com President: F. Jesus Martinez Research director: Leanna Levine, Ph.D. R&D expertise: R&D and manufacture of laboratory related products, pharmaceutical and industrial membrane filtration, cell growth. Technological expertise: CC, P/CS, BA, C/TC, BME

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Principal products/instrumentation: Contract manufacturing products, instruments, pharmaceuticals, laboratory dialysis products, SPECTRA/POR™; Process filtration products, KROSFLO™; Cell Expansion products, CELL-CO™; Chromatography products, SPECTRA/CHROM. Main products/instrumentation under R&D: Biomedical equipment/instruments for biopharmaceutical research. Sealed and granted patents: 13 patents.

2622

SPECTRUM CHEMICALS & LABORATORY PRODUCTS, INC.

Add: 14422 S. San Pedro St. Gardena, CA 90248-2027

Tel: (203) 431-7900 Web site: www.spectrum-ct.com President: Bill Clark Research director: Richard Harris R&D expertise: Automation R&D of all processes and procedures (robotics) cappers/ uncappers, tapers. Technological expertise: R, BME, AU Main products/instrumentation under R&D: Robotic work cells, contract manufacturing products, contract research/clinical trials products.

2624

SPHINX PHARMACEUTICALS CORP.

Tel: (310) 772-8000

Add: 20 T.W. Alexander Dr. P.O. Box 13959 Research Triangle Park, NC 27709

Fax: (310) 516-8000

Tel: (919) 314-4000

E-mail: [email protected]

Fax: (919) 314-4350

Web site: www.spectrumchemical.com

Web site: www.sphinxpharm.com

President/CEO: Paul Burg

President: Martin Haslanger, Ph.D.

Research director: Harris I. Lehrer, Ph.D.

Research director: Steven F. Hall, Ph.D.

R&D expertise: Research and manufacturer of fine chemicals and equipment for research and production; development of biologicals and laboratory equipment.

R&D expertise: Research of high throughput drug screening and combinatorial chemistry, applied novel product, development and manufacture.

Technological expertise: C/TC, BME

Technological expertise: COC, HTDS, SMC, R, SY

Principal products/instrumentation: Fine chemicals, laboratory equipment for drug research. Main products/instrumentation under R&D: Fine crusher, fine filter, fine particle devices. Subsidiary bodies: 755 Jersey Ave, New Brunswick, NJ 08901.

2623

SPECTRUM SYSTEMS, LLC.

Add: 21 Woodland Way P.O. Box 637 Ridgefield, CT 06877

Main products/instrumentation under R&D: Kynacyte, preclinical; high throughput drug screening, combinatorial chemistry library. Subsidiary bodies: Cambridge, MA.

2625

SPRING VALLEY LABORATORIES, INC.

Add: P.O. Box 242 Woodbine, MD 21797 Tel: (410) 795-2222 Fax: (410) 795-2242

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President/CEO: Robert M. Shaw

2627

823

SRA LIFE SCIENCES, INC.

Research director: Steve Nigida, Ph.D. R&D expertise: R&D and manufacture of polyclonal and monoclonal antibody. Market of in-stock antibodies to rabbit antigens. In vivo and in vitro GLP research manufacture services. Transgenic human CD4, rabbits and MHC matched rabbits for market.

Add: 8110 Gatehouse Rd. Ste. 600-W Falls Church, VA 22042-1210

Key license and trade contracts: NTHHTLV-l cell lines.

Research director: Patricia Williams

Technological expertise: PA, H/CF, C/TC, P/S.AB, MAE Principal products/instrumentation: Contract research/clinical trial products, monoclonal antibodies to rabbit antigens. Main products/instrumentation under R&D: Polyclonal antibodies to rabbit antigens, transgenic human CD4 rabbit.

2626

SPSS SCIENCE

Add: 233 S. Wacker Drive 11 th Floor Chicago, IL 60606-6307 Tel: (312) 651-3000 Fax: (312) 651-3668

Tel: (703) 205-8626 Fax: (703) 205-6260 President/CEO: Lawrence Glass R&D expertise: Contract R&D and project management for all aspects of drug development; production of laboratory support for drug screening; preclinical development and clinical trials of antiviral therapies; regulatory strategy of drug development and project implementation. Technological expertise: Q, AF, C/TC, GA, G, HTDS, PG, RD Main products/instrumentation under R&D: Contract research/clinical trial products, in vitro toxicology testing, vaccines, Oral, noncytotoxic anticancer (colorectal) drug, preclinical; laboratory support for drug screening, antiviral agent. Subsidiary bodies: Life Sciences Laboratory, 4 Research Ct, Rockville, MD 20850-3236; Tel: (301) 548-9158; Fax: (301) 548-2660.

Web site: www.spss.com President: Joseph Osbom Research director: Richard Mitchell, Ph.D.

2628

SRI INSTRUMENTS

R&D expertise: Development and manufacture of biomedical laboratory equipment/ instrumentation.

Add: 20720 Earl St. Torrance, CA 90503

Technological expertise: BME

Fax: (310) 214-5097

Principal products/instrumentation: SigmaPlot®, SigmaStat®, SigrnaScan™, SigmaScan™ Pro, SigmaGel™, TableCurve™ 2D, TableCurve™ 3D, PeakFit™, SigmaSuite™

E-mail: [email protected]

Main products/instrumentation under R&D: Other novel biomedical laboratory equipment.

R&D expertise: Development and manufacture of chromatography systems.

Tel: (310) 214-5092

Web site: www.srigc.com President/CEO: Hugh Goldsmith Research director: Hugh Goldsmith

Technological expertise: BME

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Principal products/instrumentation: 8610C gas chromatographs, 310 gas chromatographs, PeakSimple data system, liquid chromatography introduced in 1997. Main products/instrumentation under R&D: Chromatograph, chromatograph coupled with infrared spectrophotometer, chromatography detector.

2629

SRL, INC.

Principal products/instrumentation: Peptide map, peptide library, synthesis cosmetics. Main products/instrumentation under R&D: Peptidase A isozyme, peptide sequencer, peptide synthesizer, peptidomimetic.

2631

STAR MICRONIC DEVICES

Add: 3453/5, Delhi Chamber Bldg. Delhi-Gate New Delhi 110002 India Tel: (91) 11-2326-2865

Add: PR Section 2-41-19 Akebono-cho, Tachikawa-shi, Tokyo 190-8567 Japan

Fax: (91) 11-2327-7402

Tel: (81) 42-526-7111

R&D expertise: Development and manufacture of research drug products for universities, research institutions, industries, medical colleges and hospitals etc.

E-mail: [email protected] Web site: www.srl-group.co.jp/en/index.html President: Toshiyuki Rondo, M.D. R&D expertise: Clinical laboratory testing research services, reagents manufacturing. Technological expertise: PA, Q, C/TC, CH/S, PIS Principal products/instrumentation: In vitro toxicology testing method, reagents, clinical laboratory testing. Main products/instrumentation under R&D: Clinical laboratory test kits.

2630

STAR BIOCHEMICALS

Add: 20910 HigginsCt. Torrance, CA 905011722

President: Chander Sapra

Joint ventures: Renner GmbH, Germany; Hispanager, Spain; Kinematica Ag, Switzerland; Denver Instrument Company, U.S.A. Technological expertise: PA, E, CC, TE, T, AF, DD, AB, D-D, PMC, BI, P/S, BA, RD, BS, GA, C/TC, HTDS, SMC, H/CF, SY, COC, PIS, PG Principal products/instrumentation: Detergents, organ transplants/culture, biologicals, diagnostics, pesticides, biomaterial, plastics, food processing, process validation, biosensors, reagents, human genome project, toxic waste processing, instruments, vaccines, in vitro toxicology testing, veterinary drug products, cosmetics, natural products, enzymes, antibodies.

Tel: (310) 782-0188 Fax: (310) 782-8808

2632

STATENS SERUM INSTITUT

President: Mack Nichols Research director: Gerry Schwartz R&D expertise: Peptide synthesis research and production. Technological expertise: P/S, PIS, P, PI, PPAT, PS, PS/AP

Add: 5 Denmark

Artillerivej

Tel: (45) 3268-3268 Fax: (45) 3268-3868 E-mail: [email protected]

Copenhagen

2300

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Web site: www.ssi.dk

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CEO: Nils Strandberg Pedersen

Key license and trade contracts: LSU Health Sciences Foundation.

R&D expertise: R&D of production of vaccines.

Technological expertise: C/TC, D-D, SMC, SY

Technological expertise: C/TC

Main products/instrumentation under R&D: SCP-1 for postsurgical pain, preclinical; small molecule therapeutics.

Principal products/instrumentation: Vaccines, vaccine strain, vaccinetherapy, diagnostics. Main products/instrumentation under R&D: Vaccination

2633

STATISTICS UNLIMITED, INC.

Add: P.O. Box 13368 Savannah, GA 31411 Tel: (912) 598-9885 Fax: (912) 598-9887 E-mail: [email protected] R&D expertise: Development of biotechnology software and products manufacture. Technological expertise: CH/S, BTS, CW Principal products/instrumentation: Software package including TOXSTAT, PATHSTAT, TERATOSTAT, NEUROSTAT; Operating system including OpenVMS, other; Statistical system of software for toxicologists, pathologists, scientists to provide for the analysis and reporting of toxicology data, survival and tumor data, teratology and neurotoxicity studies.

2634

ST. CHARLES PHARMACEUTICALS, INC.

Add: Koerner Capital, LLC 650 Poydras, Suite 2830 New Orleans, LA 70130 Tel: (775) 626-0534 Fax: (775) 626-9825

Sealed and granted patents: Licensed: U.S. 5,621,110 and 5,554,636.

2635

STC LABORATORIES, INC.

Add: 348 Saulteaux Crescent Winnipeg, Manitoba R3J 3T2 Canada Tel: (204) 944-6700 Fax: (204) 944-6710 President: J. Rubenstein Research director: L. Carvalho Subsidiary of Export Packers Co. Ltd. R&D expertise: R&D and production of biotechnology drug products. Technological expertise: P/S, BA, PMC Principal products/instrumentation: Horseradish peroxidase, Avidin, Riboflavin Binding Protein, Oval Bumen. Main products/instrumentation under R&D: Novel biotechnology drug products.

2636

BOEHRINGER INGELHEIM MICROPARTS GMBH

Add: Hauert 7 Dortmund 44227 Germany Tel: (49) 231-9799-0 Fax: (49) 231-9799-100

Web site: www.stcharlespharma.com

E-mail: [email protected]

President: Kenneth W. Narducy

Web site: www.microparts.de

R&D expertise: Development and manufacture of small molecule therapeutics.

CEO: Dr. R. Wechsung Research director: Dr. R. P. Peters

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R&D expertise: Development, design, production and marketing of microstructured components and microsystems, especially mechanical, optical and fluidic devices for biomedical applied research. Subsidiary of STEAG AG, Degussa-Huls AG, VEW AG.

Main products/instrumentation under R&D: Sterile connecting device; plastic bags and systems for drug delivery, freezing bag system. Subsidiary bodies: Concord, CA — U.S.A. Sealed and granted patents: Multi-compartment bags.

Technological expertise: DD, G, HTDS, BME Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, several microstructured product.

2638

STEDIM, INC.

Add: 1910 Mark Ct. Ste. 110 Concord, CA 94520

Main products/instrumentation under R&D: Customer specific development (confidential) products, microstructure technology.

Tel: (925) 689-6650

Sealed and granted patents: In the field of microstructure technology.

Web site: www.stedim.com

Fax: (925) 689-6988 E-mail: [email protected] President: Chris Rombach Research director: Maxime Lok

2637

SARTORIUS STEDIM BIOTECH S.A.

Add: Z.I. Les Paluds Avenue de Jouques BP 1051 13781 Aubagne Cedex, France Tel: (33) 442-845-600 Fax: (33) 442-845-619 Web site: www.sartorius-stedim.com President/CEO: Bernard Lemaitre Research director: Maxime Lok R&D expertise: Research, design, development and production of plastic bags and systems for bioprocess and drug delivery applications. Key sales market contracts: Life Technologies Ltd, Pharmacia-Upjohn, Wave Biotech, Fresenius-Kabi. Technological expertise: D-D, BA Principal products/instrumentation: Bulk sterile fluid containment and shipping systems, Flexel 3D system, FlexBoy System, compounding bag system.

R&D expertise: Development and manufacture of flexible plastic containers for sterile fluid processing applications, and final drug containers. Technological expertise: BA, DD, C/TC Principal products/instrumentation: FLEXBOY™ Flexible Carboy System for volumes from 50ml to 50 liters, Custom assembly services for all size flexible containers. FLEXEL® 3D bags for volumes up to 2500 liters and FLEXEL® 3D shipping system, Palletanks made of aluminum or stainless steel for in-house preparation, storage, and dispensing of large volume sterile liquids Flexboy Mixer for ASEPTIC mixing in a closed bag system. Main products/instrumentation under R&D: Flexible containers involved with freezing applications, flexible plastic containers, final drug containers. Subsidiary bodies: Mariselle, France; Tokyo. Sealed and granted patents: Flexel® 3D Bag Design.

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2639

STELLAR BIO SYSTEMS, INC.

Add: 9075 Guilford Rd. Columbia, MD 21046 Tel: (410) 381-8550 Fax: (410) 381-8984 President: John M. Brewer Subsidiary of American Biogenetic Sciences, INC. R&D expertise: R&D and production of biotechnology medicine. Technological expertise: PA, H/CF, C/TC Principal products/instrumentation: Contract manufacturing products, contract research/clinical trial products, IFA for infectious diseases, mouse serum, in vitro diagnostic products. Main products/instrumentation under R&D: Herpes 8, preclinical; HHV6 and 8, other biotechnology medicines.

2640

STEMCELL TECHNOLOGIES, INC.

Add: 570 West Seventh Avenue, Suite 400,Vancouver, BC, Canada V5Z 1B3 Tel: (604) 877-0713 Fax: (604) 877-0704 E-mail: [email protected] Web site: www.stemcell.com President: Dr. Allen C. Eaves Research director: Terry Thomas, Ph.D. R&D expertise: R&D and production/supply of high quality hematopoietic culture media, cell separation products, software to support research in bone marrow transplantation, cancer biology and immunology. R&D collaboration: Vancouver-based BC Cancer Agency and the Terry Fox Laboratory. Technological expertise: P/S, C/TC, BTS, BS

827

Principal products/instrumentation: In vitro toxicology testing method, StemSep ™ — immunomagnetic cell separation system, ClonaCell-HY™ — hybridoma production kit, MegaCult-C ™ — megakaryocytic progenitor assay kit, 1997; MethoCult ™ — methylcellulose-based hematopoietic progenitor assay media, MyeloCult™ — long-term culture media, Stemsoft™ software for oncologists, ES-Cult ™ — for in vitro maintenance and differentiation of murine ES cells, StemSpan™ — Serum-free media for suspension cultures of human or murine hematopoietic cells, CollagenCult™ — collagen-based media optimized for the growth and quantitation of human myeloid progenitors, MesenCult-liquid media for growing human mesenchymal stem cells, 1999; Rosette-Sep™ — antibody Cocktails to enrich cells directly from whole blood, StemCell QC-quality control kit to monitor month to month consistency in colony assay set up and progenitor laboratory, Contract Assay Service — customized hemotopoietic progenitor assays to meet individual requirements, StemSpan™ H200 — serum-free, animal- free media, manufactured in a GMP compliant facility, 2000; StemCell QC — quality control kit to monitor month-to-month consistency in colony assay setup and progenitor enumeration within a cell processing laboratory, Contract Assay Service — customized hematopoietic progenitor assays to meet individual requirements, StemSpan™ H2000 — serum-free, animal-free media, manufactured in a GMP-compliant facility. Main products/instrumentation under R&D: High quality hematopoietic culture media, cell separation products. Subsidiary bodies: StemCell Technologies Production and Research Facility, 27 East 7th Ave., Vancouver, BC, Canada VST 1M4, Tel: (604) 877-0713, Fax: (604) 876-8440; StemCell Technologies France, 29 Chemin du Vieux Chene, Z.I.R.S.T., 38240 Meylan

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France, Tel: (33) 04-7604-7530; Fax: (33) 047618-9963; E-mail: [email protected] Sealed and granted patents: U.S. patent #4,868,109; Method for preventing and/or treating renal disease, 6,306,827, U.S.; Method for separation cells using immunorosettes. 6,448,075, U.S.

product groups include: hormones, vitamins, steroids, anesthetics; Drug dosage forms, include: oral, injections, eye and ear products in solution, suspension, and lyophilized forms.

2643

STERI TECHNOLOGIES, INC.

Add: 857 Lincoln Ave. Bohemia, NY 11716 2641

STEM CORPORATION

Tel: (800) 253-7140 Fax: (631) 563-8378

Add: 419 Sutton Rd. Soutliend-on-Sea, Essex SS2 5PH U.K. Tel: (44) 1621-868-685

Web site: www.steri.com President/CEO: Clemens Nigg

President: Chris Orlopp

R&D expertise: Research, manufacture and supply of filtration equipment and sanitary process equipment.

R&D expertise: R&D and production of combinatorial chemistry equipment

Key license and trade contracts: North American Licensee for FUNDA Filter.

Technological expertise: COC, SY, CC, BME

Technological expertise: BME

Principal products/instrumentation: REACTO-STATIONS™, parallel synthesis reactors, combinatorial chemistry equipment.

Principal products/instrumentation: ZWAG® Nutsche Filter/Dryer, FUNDA® Filter, Aseptomag, Aseptic valve and production systems, stainless steel sterile containers, sterile sampling valves and systems.

Fax: (44) 1621-868-445

Main products/instrumentation under R&D: Combinatorial organic synthesis.

2642

STERIS LABORATORIES, INC.

Add: 620 North 51st Ave. Phoenix, AZ 850432702 Tel: (602) 278-1400 President/CEO: Martin Sperber

Main products/instrumentation under R&D: Novel filtration equipment, sanitary process equipment.

2644

STEROGENE BIOSEPARATIONS, INC.

Research director: Fakrul Sayeed

Add: 5922 Farnsworth Court Carlsbad, CA 92008

Subsidiary of Schein Pharmaceutical

Tel: (760) 929-0455

R&D expertise: Manufacture and supply of multisource injectables, ophthalmics and optics drugs. Manufacture of applied novel products on a contract/R&D basis.

Fax: (760) 929-8720

Technological expertise: DD

President: Peter Grandics, Ph.D.

Principal products/instrumentation: Contract manufacturing products, INFED® (Iron Dextran Injection USP); Key therapeutic drug

Research director: Peter Grandics, Ph.D.

E-mail: [email protected] Web site: www.sterogene.com

R&D expertise: Development and manufacture of biochromatography services resins, and kits.

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Technological expertise: F, C/TC, P/S, BA Principal products/instrumentation: Actigel ALD, ActiSep, QUICKmab, ActiClean Etox, Actigel ALD Superflow, Heparin Actigel, Heparin Superflow, QUICKMeasure, Cellthru BigBeads, Thruput Ion Exchange resins, DNA Etox. Subsidiary bodies: Sterogene Europe — Brussels Belgium.

2645

829

Assoc, brand of fluorometers, luminometers and shakers for biopharmaceutical research. Technological expertise: PIS, BME, PS, P/PS, PI, PPAT Principal products/instrumentation: BioTherm BioOven III; Fluoro-Tec Fluorometer; Lumi-Tec, Lumi-nometer; Model 1000 Amino Acid Analyzer, Peptide Flask Shaker. Main products/instrumentation under R&D: BioTherm thermocyclers.

STI INTERNATIONAL, INC. 2647

STRATEGIC DIAGNOSTICS, INC.

Add: Momijigaoka 1-27-14 Fuchu, Tokyo 183-0004 Japan

Add: 111 Pencader Dr. Newark, DE 19702

Tel: (81) 423-67-1631

Tel: (302) 456-6789

Fax: (81) 423-58-6031

Fax: (302) 456-6770

E-mail: [email protected]

Web site: www.sdix.com

President: Tatsuzo Ishigami, Ph.D.

President/CEO: Richard C. Birkmeyer, Ph.D.

R&D expertise: International consultation in biotechnology, medical, and health, therapeutic drugs development and manufacture. Technological expertise: C/TC, GT, G. Principal products/instrumentation: Products for research cell therapy, gene therapy, pharmaceutical laboratory diagnostics, medical IT. Main products/instrumentation under R&D: Healthcare drug, health protection agents, antiaging agents.

2646

ST. JOHN ASSOCIATES, INC.

Add: 4805 Prince George’s Ave. Beltsville, MD 20705

Research director: James W. Stave, Ph.D. R&D expertise: Research, design, development and manufacturing of test kits for environmental pollutions and agricultural products. Joint ventures: Strategic BioSolutions, California Tel: (800)481-9737. Technological expertise: C/TC Principal products/instrumentation: Agriculture, pesticides, environmental, reagents, RapidChek II sulfate reducing bacteria test, D Tech priority pollutant tests; EnSysRisc Environmental Products; RapidAssay Environmental Products; TraitCheck GMO Product Line. Main products/instrumentation under R&D: Immunoassay test kits for environmental compounds, development.

Tel: (301) 595-5605 Fax: (800) 837-2023 Web site: www.stjohnassociates.com

2648

STRATEGIC PLANNERS INTERNATIONAL, INC.

President: Peter A. St John R&D expertise: Manufacture and marketing of BioTherm brand of thermocyclers, St John

Add: P.O. Box 7633 Libertyville, IL 60048 Tel: (847) 816-6112

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Fax: (847) 816-6113 President: Thomas D. Evans

compounds; anti-obesity; anti-cancer; antirestenosis; anti-inflammatory.

Research director: R.H. Schleif, Ph.D. R&D expertise: Pharmaceutical and biotechnology medicine manufacturing consulting; domestic and Latin America. Technological expertise: F, LP, pharmaceutical manufacturing, capacity planning, international operations. Principal products/instrumentation: Biologicals, vaccines, reagents, enzymes, peptides, antibiotics, specialty chemicals, monoclonal antibodies, pharmaceuticals.

2650

STRESSGEN BIOTECHNOLOGIES CORP.

Add: 4243 Glanford Ave. Victoria, British Columbia V8Z 4B9 Canada Tel: (604) 744-2811 Fax: (604) 744-2877 President/CEO: Dan Korpolinski Research director: Dr. Marvin Slegel

Add: 27 Taylor St. Glasgow G4 0NR U.K.

R&D expertise: Novel drugs R&D and manufacture, focused on the discovery and development of novel immunotherapeutic products for cancer and infectious disease, and its research and development programs.

Tel: (44) 141-553-4155

Joint ventures: Genzyme Molecular Oncology.

Fax: (44) 141-552-8376

Key sales market contracts: Distributors in 26 countries.

2649

STRATHCLYDE INSTITUTE FOR DRUG RESEARCH

E-mail: [email protected] Web site: www.sidr.org President: Prof. Alan Harvey Research director: Nigel Pyne Subsidiary of Strathclyde University. R&D expertise: Early stage drug discovery screening research; natural products development; contract research/manufacture. R&D collaboration: Welfide; KOWA. Technological expertise: CC, E, F, SY, DD, AF, CB, C/TC, COC, D-D, GT, HTDS, PIS, P/S, SMC Main products/instrumentation under R&D: Many small M.W. compounds from plants, Natural product collection for high throughput screening, Anti-Psoriasis compounds, AntiObesity compounds, Anti-Alzheimer’s compounds, Anti-Anxiety compounds — all products preclinical; Restenosis prevention. Sealed and granted patents: Novel process for boron compounds; jasmonates; anxiolytic

Key license and trade contracts: 30 agreements with 24 institutions globally. Technological expertise: PA, Q, H/CF, RD, GT, C/TC, P/S, RPP, P/PS, PPAT Principal products/instrumentation: Developed two approaches to cancer therapy: recombinant fusion protein dierapeutics and stress protein gene therapy; lead products in these areas target cervical dysplasia and ovarian cancer respectively; stress protein, protein trafficking, signal transduction and apoptosis research reagents. Main products/instrumentation under R&D: SGN-00101 HspE7 to treat human papillomavirus-related dysplasia and cancer, Phase II/III; developed two classes of products designed to target the immune response against infectious diseases: subunit vaccines, using pathogen-specific stress proteins; and fusion proteins, using stress proteins and pathogenspecific antigens.

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Sealed and granted patents: StressGen’s patent portfolio includes exclusive licenses from MIT’s Whitehead Institute of Biomedical Research, the Medical Research Council in the U.K., and several granted and filed use applications; immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein of an expression vector capable of expression of these proteins, 6,900,035, U.S.; other patents are pending.

2651

STRONG PHARMACEUTICALS, INC.

831

R&D expertise: R&D of computational proteomics. developed proprietary algoithms to generate 3-dimensional structural models of proteins from primary gene sequence data, and to perform primary drug discovery screening in silico. R&D collaboration: Quest Diagnostics Incorporated. Technological expertise: BI, CH/S, D-D, G, PG Principal products/instrumentation: ProMax™, Variome™, Structural-Bank™. Subsidiary bodies: Cambridge, MA; Horsholm, Denmark.

Add: One Sage Lane Framingham, MA 01701 Tel: (508) 877-3988

2653

STRUCTURAL PROTEOMICS

President/CEO: Barry A. Berkowitz, Ph.D. R&D expertise: Research of drug discovery, drug contract R&D and production.

Add: 10 McKinleySt. Ste. 11 Closter, NT 07624

Technological expertise: F, AF, BI, C/TC, COC, DD, D-D, HTDS, GT, RD

Tel: (201) 784-1006

Principal products/instrumentation: Organ transplants/culture products, contract R&D drug products.

E-mail: [email protected]

Main products/instrumentation under R&D: Drug discovery products, drug contract R&D products; Phase II NSCLC trial data still not translating into phase III success, 2010.

Fax: (201) 784-9121 President/CEO: A.T. Hagler Research director: R. Fine Subsidiary of Discovery Partners International. R&D expertise: Virtual Screening/Proteomics Structural Analysis. Technological expertise: DD, D-D, DDI

2652

STRUCTURAL BIOINFORMATICS, INC.

Principal products/instrumentation: Contract R&D products, vaccines.

Add: 10929 Technology Place San Diego, CA 92127

Main products/instrumentation under R&D: Virtual drug screening, protein structure analysis.

Tel: (858) 675-2400 Fax: (858) 451-3828 E-mail: [email protected]

2654

STS DUOTEK, INC.

Web site: www.strubix.com

Add: 7500 W. Henrietta Rd. Rush, NY 14543

President/CEO: Edward T. Maggio, Ph.D.

Tel: (585) 533-1672

Research director: Kal Ramnaravan, Ph.D.

Fax: (585) 533-1796

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E-mail: [email protected] Web site: www.stsduotek.com President: James Whitbourne Technological expertise: PA, DD, D-D, DDI R&D expertise: R&D of drug delivery, polyclonal antibodies and other biotechnology medicines; novel drug products manufacture and marketing. Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, in vitro toxicology testing. Main products/instrumentation under R&D: Drug delivery route, polyclonal antibodies, biopolymers. Subsidiary bodies: Sterilization Technical Services, 7500 West Henrietta Rd, Rush, NY 14543, Tel: (716) 533-1672, Fax: (716) 5331796; STS Biopolymers, INC., 336 Summit Point Drive, Henrietta, NY 14467, Tel: (716) 321-1130, Fax: (716) 321-1575; DuoTEK division of STS duo TEK, INC., 5829 County Road #41, Farmington, NY 14425, Tel: (716) 398-3910, Fax: (716) 398-3833; STS Particles, INC. (also known as Medisperse LLP), 336 Summit Point Drive, Henrietta, NY 14467, Tel: (716) 321-1130, Fax: (716) 321-1575.

2655

SUGEN, INC.

Add: 230 East Grand Ave. South San Francisco, CA 94080

R&D collaboration: Angen, INC. in neurobiology and stem cells; Zeneca in novel cancer targets. Technological expertise: F, Q, E, SY, COC, RD, P/S, GA, R, H/CF, C/TC, CH/S Main products/instrumentation under R&D: SU101 (PDGF-receptor tyrosine kinase inhibitor) to treat malignant glioma, Phase III/IV; prostate cancer, Phase II/III; solid tumaos, Phase II/III; SU101 (small molecule antagonist of PDGF-receptor) for brain and ovarian cancers; SU5416 (angio-genesis) inhibitor for colorectal cancer and AIDS/HIV, Phase III/IV; SU6668 (angiogenesis to treat solid tumors, Phase II; HER-2 antagonist for breast and ovarian cancers; FIK-1 receptor antagonist for angiogensis inhibition, small molecule drugs targeting tyrosine kinase, tyrosine kinase substrate proteins. Subsidiary bodies: Dr. Joseph Schlessinger, NYU Medical Center, Dept. of Pharmacology, 560 First Ave., NY, NY 10016. Dr. Axel Ullrich, Max-Planck Institute for Biochemie, AM Hopferspitz 18A, 8033 Martinsried Bel Munchen, Germany. Sealed and granted patents: Nucleic acid molecules encoding CASPR/p190. 6,465,210, U.S.; Diagnosis and treatment of SAD related disorders. 6,388,063, U.S.; Diagnosis and treatment of ALP related disorders. 6,342,593, U.S.; Tyrosine kinase substrate proteins. 7,029,912, U.S.; rdgB proteins and related products and human orthologues of wart. 6,495, 353, U.S.; Novel kinases, 20070202107, U.S.

Tel: (650) 553-8300 President: James L. Tyree Research director: Axel Ullrich R&D expertise: Drug discovery, R&D and manufacture of small molecules drugs targeting tyrosine kinases and tyrosine phosphatases in therapeutic action for cancer, diabetes and angiogenesis.

2656

SUMMIT BIOTECHNOLOGY

Add: 701 Centre Ave. Fort Collins, CO 80524 Tel: (970) 221-2755 Fax: (970) 221-9238 President: Rick Paniccia

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Research director: Rick Paniccia R&D expertise: R&D and manufacture/ marketing of animal sera. Technological expertise: C/TC Principal products/instrumentation: Animal Sera (FBS, NBS, BCS), including horse; Research Sera ™, U.S. origin bovine sera. Main products/instrumentation under R&D: Animal cell culture, animal cell lines.

833

Principal products/instrumentation: Vials, caps, septa, glassware, plastics, microplates, plate closures. Main products/instrumentation under R&D: Chromatography accessories, sample preparation.

2659

SUNPHARM CORPORATION

Add: 4651 Salisbury Road Suite 205 Jacksonville FL 32256 Tel: (904) 296-3320

2657

SUN DANCE GENETICS

Fax: (904) 296-6202

Add: 8 Pilton Place Durham, NC 27705

President/CEO: Stefan Borg

Tel: (919) 490-5380

Research director: Michael T. Cullen

Fax: (919) 660-7425 E-mail: [email protected] President: M.W. Eubanks, Ph.D. R&D expertise: Research of improved maize germplasm, and novel maize products development. Technological expertise: Q, G, RD Main products/instrumentation under R&D: Maize lines resistant to corn rootworm; improved maize germplasm; drought resistant maize; weevil resistant maize; maize germplasm storage.

2658

SUN INTERNATIONAL

R&D expertise: Drug discovery research; development of polyamine-based analogues and iron chelators for human pharmaceuticals, related products manufacture. Key license and trade contracts: WarnerLambert Company and Nippon Kayaku Co., Ltd have acquired rights to DENSPM for anticancer uses. Technological expertise: SMC, D-D Main products/instrumentation under R&D: DENSPM, Phase II, for the treatment of cancer; DEHOP, Phase II, for treatment of AIDS-related diarrhea.

2660

SUPELCO

Add: 3700 Highway 421 North Wilmington, NC 28401

Add: Sigma-Aldrich Corp. St. Louis, MO

Tel: (800) 522-8425

Fax: (314) 771-5757

Fax: (800) 231-7861

E-mail: [email protected]

E-mail: [email protected]

Web site: www.sigmaaldrich.com

President: Barney Siegel

President: J. Russel Gant

R&D expertise: Development and manufacture of chromatography accessories/sample preparation.

Subsidiary of Sigma-Aldrich Corp.

Tel: (314) 771-5765

R&D expertise: R&D of chromatography products.

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Technological expertise: P/S, HTDS Principal products/instrumentation: Novel chromatography products, contract R&D chromatography products.

2661

SUPERCOOL US

Add: 4025 Watertown Road Minneapolis, MN 55359 Tel: (952) 745-9238 Fax: (952) 745-9381 E-mail: [email protected] Web site: www.supercool.se President: Davel Cech R&D expertise: Development and production of thermoelectric cooling assemblies and molecules.

Key license and trade contracts: Bristol Myers-Squibb, Mylan. Technological expertise: D-D, DD, CS, CSDP Principal products/instrumentation: EpiPen auto-injector, Cartrix2000™ with whisperpoint needle syringe system, nerve agent antidote, contract manufacturing pharmaceuticals, CytoGuard™ aerosol protection device. Main products/instrumentation under R&D: Absorption enhancers for large proteins, thrombolytic and related agents, high technology parenteral drug delivery systems, unique automatic injector systems. Subsidiary bodies: Survival Technology, INC., 2550 Hermelin St, St Louis, MO 63144.

2663

SWITCH BIOTECH LLC

Technological expertise: BME Principal products/instrumentation: Assemblies and modules, Supercool devices.

Add: P.O. Box 11375 Conway, Arkansas AR 72034

Main products/instrumentation under R&D: Numerous thermal management; medical and Bread Board through laboratory devices.

E-mail: [email protected]

Sealed and granted patents: Various design patents.

Research director: Dr. Andreas Goppelt

2662

SURVIVAL TECHNOLOGY, INC. (STI)

Add: 2275 Res Blvd Ste 100 Rockville, MD 20850 Tel: (301) 926-1800 President/CEO: James H. Miller R&D expertise: R&D and manufacture of high technology parenteral drug delivery systems designed to combine new chemical entities and off patent drugs for use in a unique automatic injector system. Joint ventures: Tri-West. R&D collaboration: E. Merck. Key sales market contracts: E. Merck. L

Web site: www.switch-biotech.com President/CEO: Dr. Gabriele Stumpf R&D expertise: Development, manufacture and marketing of innovative therapeutics in wound healing and dermatology. R&D collaboration: ETH Zurich, University of Munich. Technological expertise: T, BI, G, RD Main products/instrumentation under R&D: Validated targets, preclinical; innovative therapeutics in wound healing and dermatosis. Sealed and granted patents: Proprietary screening technology for quantitative gene expression analysis.

2664

SYBRON CHEMICALS, INC.

Add: 111 RIDC Park West Drive Pittsburgh PA 15275-1112

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Tel: (412) 809-1000 E-mail: [email protected] Web site: www.lanxess.com President/CEO: Richard M. Klein, Ph.D. Research director: D. Miller R&D expertise: Biodegradation research of wastes, from cleaning and odor control products to waste treatment and bioremediation, novel products development/manufacture. Key sales market contracts: Betz Laboratories, industrial wastewater treatment. Technological expertise: F

835

Key license and trade contracts: Issued patents licensed from private/academic sources dealing with the development of platform technologies and products focusing on novel approaches to enhance carbonyl trapping. Technological expertise: SMC, C/TC, DD, DD, HTDS Main products/instrumentation under R&D: CogniMax™ for treatment of Alzheimer’s Disease, preclinical; FlexiTabs® for treatment of anti-inflarnmoratory disease, preclinical; Oxitabs for treatment of OTC Anti-aging, preclinical.

Principal products/instrumentation: Contract manufacturing products, BI-CHEM® 1000 Series for industrial waste treatment; BICHEM® 2000 Series for municipal applications; ABR® products for bioremediation, BI-CHEM MSB for cleaning and odor control.

Sealed and granted patents: U.S. #5668117, 668682, 674330, 692454, 698881.

Main products/instrumentation under R&D: Products for agriculture, industrial wastewater treatment, waste biodegradation.

Add: Pittsboro, NC 27312

Subsidiary bodies: R&D Facility: 111 Kesler Mill Rd, Salem, VA 24153; Overseas Facilities: France, Japan, Canada and South Africa.

E-mail: [email protected]

Sealed and granted patents: BioSockapplication technique, BDO-biological drain opener.

R&D expertise: Development and manufacture of advanced diagnostic technology and products.

2666

SYLVANUS

Tel: (919) 545-0552 Fax: (919) 545-0553 President: Stephen B. Friedman, Ph.D.

Technological expertise: Q, H/CF, SY, RD, C/TC, AB, COC, G, HTDS, P/S, PIS. 2665

SYLVANLFTBS™

Principal products/instrumentation: Advanced diagnostics, contract R&D products.

Add: P.O. Box 694 Langhorne, PA 19047 Tel: (215) 741-1165 Fax: (215) 741-1324 E-mail: [email protected]

2667

SYMBIO

President/CEO: Dale M. Lombardi

Add: 38 Bookham Industrial Park Church Road, Great Bookham Surrey KT23 3EU U.K.

Research director: Dr. Howard Shapiro

Tel: (44) 137-245-6101

R&D expertise: Discovery, research, design, development and marketing of ethical and over-the-counter(OTC) products for treatment of degenerative neurological diseases and chronic inflammatory disorders.

Fax: (44) 137-245-6099 E-mail: [email protected] CEO: Martin Ward Research director: Helen Wakerley

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R&D expertise: Research of wastewater, agriculture and sports turf. Naturally occurring bacteria, fungi and enzymes to combat environmental pollution. Very powerful environmentally friendly biotech cleaning products that replace acids, alkalis, solvents and bleaches. A range of microbes and nutrients to improve the efficiency of overloaded or malfunctioning treatment plants for sewage and industrial effluent. A complete development for water resource and contaminated soil management. R&D collaboration: University of London, Royal Holloway College. Key license and trade contracts: ARASt. Maur, France. Technological expertise: E, F, AF, COC Principal products/instrumentation: Mycorrbizal inoculants for tree, plants and grass; Green Circle range of bacteria and fungi for horticulture and sports turf; range for wastewater and industrial environment; Enzymactic surface cleaners.

2668

SYMBIONTICS, INC.

Add: 4041 Forest Park Ave. St. Louis, MO 63108 Tel: (314) 615-6966

2669

SYMBIOTECH, INC.

Add: 8 Fairfield Boulevard Wallingford, Connecticut CT 06492-1895 Tel: (203) 949-2766 Fax: (203) 949-2769 President: Edward M. Davis, Ph.D. Research director: Robert Coughlin, Ph.D.; Edward M. Davis, Ph.D. R&D expertise: R&D and manufacture of chemiluminescent DNA detection reagents and devices, liquid-liquid extraction technology, blood filtration technology, antibiotics and anti-cancer drugs and biosensors. Technological expertise: F, CC, RD, P/S, C/TC, AF, G, HTDS, PMC Main products/instrumentation under R&D: Blood filtration devices; remediation of fuel spills; anti-cancer agents; blood plasma preparation systems; anti-microbials, biosensors, chemiluminescent, DNA detection reagents and devices. Sealed and granted patents: #4, 978,650; #5,252,220; #5,277,821.

2670

BIOCON

Fax: (314) 615-6901

Add: 20th KM, Hosur Road, Electronics City, Bangalore, 560 100 India

President/CEO: Dennis E. Vaccaro

Tel: (91) 80-2808-2808

R&D expertise: Development and manufacture of therapeutic protein

Fax: (91) 80-2852-3423

Key sales market contracts: Harvard University, Washington University.

Web site: www.biocon.com

Technological expertise: Q, T, E, PC, C/TC, PG, DD, RD, BI, G, GT, P/S, CH/S Main products/instrumentation under R&D: Novel platform technology for manufacturing and delivering human therapeutic proteins products in preclinical phase.

E-mail: [email protected] President: Kiran Mazumdar-Shaw Research director: Goutam Das, Ph.D. R&D expertise: CRO; development of biotech novel drugs. Technological expertise: Q, CC, BI, RD, SMC, COC

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Principal products/instrumentation: Chemicals, reagents, contract research/clinical trial products. Main products/instrumentation under R&D: Novel biotech drugs.

2671

SYNAPTIC PHARMACEUTICAL CORP.

Add: 215 College Rd Ste 100 Paramus, NJ 07652

837

gene construction, recombinant antibody engineering, gene expression, etc. Technological expertise: F, PA, Q, DH/CF, P/S, RD, SY, BA, C/TC, COC, GA, GT, HTDS Principal products/instrumentation: Biologicals, biomaterials, contract manufacturing products, contract research/clinical trial products, diagnostics, pharmaceuticals, reagents, vaccines. Main products/instrumentation under R&D: Recombinant protein, gene expression system, gene construction technology.

Tel: (201) 261-1331 Fax: (201) 261-0623 President/CEO: Kathleen P. Mullinix, Ph.D.

2673

Research director: Robert I. Taber, Ph.D, R&D expertise: Pharmaceutical R&D based on discovery of novel receptors in central and peripheral nervous systems, novel drugs manufacture. R&D collaboration: Eli Lilly & Co., serotonin; Merck & Co., INC., prostate-related urinary retention; Ciba-Geigy Limited, Neuropeptide Y. Technological expertise: Q, SMC, RD, P/S, C/TC, SY, D-D, COC Main products/instrumentation under R&D: Novel cloned human neuroreceptors: serotonin, adrenergic; neuropeptides, therapeutics for prostate-related urinary retention.

2672

SYNCOMM CORPORATION

SYNERGISTIC DETECTOR DESIGNS

Add: 16610 East Laser Drive Suite 4 Fountain Hills, Arizona AZ 85268 Tel: (480) 816-0793 Fax: (480) 816-0793 E-mail: [email protected] Web site: www.solidstatecamera.com President/CEO: Dr. Arthur H. Rogers R&D expertise: Research of Customized CCD cameras and camera systems, novel products development. Technological expertise: CH/S, HTDS. Principal products/instrumentation: Contract manufacturing products, contract R&D instruments, CCD cameras that have been built for the following applications: high throughput screening, electrophoresis, high resolution imaging diagnostics.

Add: 3401 Market St. Philadelphia, PA 19104 Tel: (215) 387-2811 Fax: (215) 387-2886 President/CEO: Randall Keith Research director: Robert Smith R&D expertise: Research and manufacture of contract item products, recombinant protein,

2674

SYNERGY PHARMACEUTICALS,INC.

Add: 420 Lexington Avenue, Suite 1609 New York, NY 10170 Tel: (212) 297-0020

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Fax: (212) 297-0019

Tel: (44) 12-2325-7788

E-mail: [email protected]

Fax: (44) 12-2325-7888

Web site: www.synergybio.net

CEO: Steve P. Gardner, Ph.D.

President/CEO: Donald Picker, Ph.D.

Research director: Tom Flores

Research director: Gary Jacob, Ph.D.

R&D expertise: Integration of pharmaceutical, biopharmaceutical and agrochemical research information.

Joint ventures: Sintopharma — Sao Paulo, Brazil. Key sales market contracts: Gador — Buenos Aires, Argentina. R&D expertise: Research of carbohydrate biotechnology and hepatitis therapy, related products development. Technological expertise: PA, CB Main products/instrumentation under R&D: Therapeutic agents for hepatitis B&C; drug for treatment of herpes simplex keratitis, carbohydrate biotechnology preparation. Sealed and granted patents: Iminosugars.

R&D collaboration: Incyte Pharmaceuticals, a joint development initiative to integrate lifetools with synomics framework for research informatics. Technological expertise: BI, CH/S, PG Principal products/instrumentation: Agriculture, Human Genome Project, biopharmaceuticals, agrochemical information.

2677

SYNPEP CORP.

Add: 6905 Sierra Court Dublin, CA 945682641 2675

SYNERGY RESEARCH CORP.

Tel: (925) 803-9250

Add: P.O. Box 5056 Hanover, NH 03755

Fax: (925) 803-9676

Tel: (603) 298-5349

President/CEO: Dr. Chi C. Yang

Fax: (603) 298-8513

Research director: Dr. Chi C. Yang

President: James C. Dean.

R&D expertise: Research of custom peptides, catalog peptides, peptide-related technology and related novel products development.

Research director: Robert C. Dean, Jr. R&D expertise: Process engineering research and related novel products development. Technological expertise: F, P/S, BA, C/TC, PMC Principal products/instrumentation: Biologicals, pharmaceuticals, diagnostics, food processing products, vaccines, cell/tissue culture, enzymes, reagents, antibodies.

2676

SYNOMICS, LTD.

Add: Compass House Vision Park Histon Cambridge, CB4 9AD U.K.

Technological expertise: P/S, SY, PI, PIS, PPAT, PS, E, ET Principal products/instrumentation: Human osteocalcin (1–49), catalog peptides, amino acids, resins, enzyme substrates, symmetrical multiple antigenic peptide systems. Refill of ABI-amino acid cartridges, mass spectral analysis services, radio-labeled peptide synthesis.

2678

SYNPHAR LABORATORIES, INC.

Add: Taiho Alberta Center Suite 2 4290-91A Street Edmonton Alberta T6E 5V2 Canada

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Tel: (780) 462-4044 Fax: (780) 461-0196 President/CEO: Dr. R. G. Micetich Research director: M. Daneshtalab R&D expertise: Design, development, synthesis and testing of novel human pharmaceuticals, specializing in area of infectious diseases. Joint ventures: Taiho Pharmaceutical Co. Ltd., Japan. R&D collaboration: Taiho, Japan; Parke Davis, U.S.; Janssen, Belgium. Technological expertise: AF, C/CT, COC, DD, HTDS, SY Principal products/instrumentation: Tazobactam; Mefozolac. Main products/instrumentation under R&D: ß-lactamase inhibitors, antifungals, cysteine protease. Sealed and granted patents: Numerous related to: ß-Lactamase inhibitors, antifungals, fluoroquinolones, oxapenams, elastase, cysteine protease.

839

PK® for E. coli infections), Pharmascience (Canada for SYNSORB PK® for Exoli infections). Technological expertise: CB, COC, SY Main products/instrumentation under R&D: SYNSORB PK® for treatment of E. coli infections, Phase III/IV; SYNSORB CD® — Recurrent C. difficile infections, Phase III; SYNSORB TD® — Traveler’s diarrhea, preclinical; library of carbohydrate combinatorial chemistry compounds, R&D relations. Sealed and granted patents: SYNSORB Biotech has been issued a variety of patents with respect to the products listed under main products/instrumentation under R&D.

2680

SYNT: EM

Add: Parc Scientifique Georges Besse 145 Nîmes Cedex 1 30035 France Tel: (33) 46-6048-666 Fax: (33) 46-6048-667 President: Michel Kaczorek

2679

SYNSORB BIOTECH, INC.

Add: Suite 410, 1167 Kensington Crescent, NW Calgary Alberta T2N 1X7, Canada Tel: (403) 283-5900 Fax: (403) 283-5907 E-mail: [email protected] President/CEO: Brad Thompson Research director: David Rafter R&D expertise: Carbohydrate-based pharmaceuticals for gastroenteric conditions. Key sales market contracts: Takeda Chemical Industries Ltd (Japan for SYNSORB PK* for E. coli infections), Pharmascience (Canada for SYNSORB PK® for E. coli infections). Key license and trade contracts: Takeda Chemical Industries Ltd (Japan for SYNSORB

Research director: Anthony Rees R&D expertise: Research of drug discovery and brain delivery technologies. R&D collaboration: Sangstat-IntrabioticsSynthelabo-Oxford Asymmetry-Servier. Key license and trade contracts: CNRS (modeling- peptide-intracellular delivery). Technological expertise: PI, PA, SY, S, CS, P, DDI, COC, DD, CB, PIS, BI Principal products/instrumentation: In silico screening biological on contract. Main products/instrumentation under R&D: R&D of two complementary technologies: Actimap and Peptians, which create original patentable drug candidates. Actimap, a drug discovery and potimisation engine based on pharmainformatrics. Peptians, a series of proprietary vectors that enable transport of drugs

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into the brain, peptides transportation for brain delivery, preclinical. Sealed and granted patents: Pep: Trans — Brain Delivery; Drug Discovery Engines — In Silico Screening.

2681

USA SYNTHECON, INC.

Add: 8044 El Rio Houston, Texas TX 770544185 Tel: (713) 741-2582 Fax: (713) 741-2588

owns 4 patents, and has exclusive license to 4 NASA equipment patents and co-exclusive license to 10 NASA methods patents (~2001); Methods for efficient production of mammalian recombinant proteins. 6,902,909, U.S.; Vessel, preferably spherical or oblate spherical for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same. 6,642,019, U.S.; Disposable culture bag. 6,673,598, U.S.

2682

SYNTHETECH, INC.

Web site: www.synthecon.com

Add: 1290 Industrial Way Albany, Oregon OR 97322,

President: C. D. Anderson

Tel: (541) 967-6575

Research director: Dr. Stephen Navran

Fax: (541) 967-9424

R&D expertise: R&D and production of bioreactors for culturing sophisticated cell types, including three-dimensional co-cultures of mammalian and insect cells, and also, including differentiated tissue models.

E-mail: [email protected]

E-mail: [email protected]

Joint ventures: Sponsored research agreement with the Baylor College of Medicine. R&D collaboration: North Texas Health Science Center.

Web site: www.synthetech.com President/CEO: M. ‘Sreeni’ Sreenivasan Research director: Tim Fitzpatrick R&D expertise: Development, design and manufacture of novel amino acids and amino acid derivatives for peptides and other pharmaceuticals.

Key sales market contracts: Cellon, innovative biotechnologies.

Key license and trade contracts: Miwon Co., aspartame technology; Biomeasure, INC., specialty amino acids.

Key license and trade contracts: Exclusive NASA license to manufacture and market the patented rotary wall vessel technology.

Technological expertise: F, E, CC, CS, BA, SY, SMC, C/TC, P/PS, PS/AP, PIS, PI

Technological expertise: TE, H/CF, C/TC Principal products/instrumentation: Rotary cell culture system™, Biologicals, biomaterials, organ transplants/culture. Main products/instrumentation under R&D: Recombinant human proteins, biorealtors for culturing sophisticated cell type, mammalian recombinant proteins. Sealed and granted patents: Three hardware and 2 process patents covering the NASAdeveloped bioreactor technology. Synthecon

Principal products/instrumentation: Peptide building, blocks (BOC, CBZ and FMOC protected amino acids), alpha-amino alcohols produced on a scale of kilos to tons. Dimers to tetramers made to order on bulk multi-kilo scale using solution synthesis; specialty amino acids and derivatives. Main products/instrumentation under R&D: Various specialty amino acides and amino alcohols. Subsidiary bodies: Multipurpose fine chemical synthesis plants-kilos to tons.

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2683

SYNTHETIC GENETICS

841

Tel: (913) 888-8876 Fax: (913) 894-9373

Add: 3347 Industrial Ct. San Diego, CA 92121

President: Raul E. Kohan

Tel: (619) 793-2661

Research director: J. Donald Todd, D.V.M.

Fax: (619) 793-2666

R&D expertise: Development and production of genetically modified veterinary vaccines.

Web site: www.syntheticgenetics.com Research director: Ed Lusby

Joint ventures: Syntro Venture Corp. & Nippon Zeon of America) created Syntro Zeon.

R&D expertise: Research and production of DNA based reagents/diagnostics.

R&D collaboration: Nippon Zeon, poultry vaccines.

Technological expertise: Q, RD, SY, AB, GA

Key sales market contracts: ScheringPlough, swine vaccine.

CEO: Ben Thorton

Principal products/instrumentation: Synthetic DNA and DND detection. Main products/instrumentation under R&D: DNA based reagents/diagnostics.

2684

SYNTRACHEM, LLC.

Add: 750 Harris St. Ste. 103 Charlottesville, VA 22903 Tel: (804) 977-9026

Technological expertise: C/TC, RD, GA Principal products/instrumentation: PRV Marker, PRV Marker Gold, MaxiVac Flu, antibodies. Main products/instrumentation under R&D: Poultry vaccines, swine vaccines, genetically modified veterinary vaccines. Subsidiary bodies: Research Laboratories, 3535 General Atomics Ct., San Diego, CA 92121.

Fax: (804) 296-8331 President: Christine M. Conroy, Ph.D. Research director: Gary S. Parkhill

2686

SYNTRON BIORESEARCH, INC.

R&D expertise: Development of products for parallel synthesis and sample preparation.

Add: 2774 Loker Ave. West Carlsbad, CA 92008

Technological expertise: CC, COC, PIS, SMC, SY

Tel: (760) 930-2200

Principal products/instrumentation: Evaporation Products, MultEvap products, SyntraHeat, Synthesis Reaction Modules, SyntraPrep, Filtration Products, Syntra-Funnel, TLC Products, SyntraPlate, Syntra-Mark. Main products/instrumentation under R&D: Parallel synthesis and sample preparation technologies.

2685

SYNTRO CORP.

Add: 9669 Lackman Rd. Lenexa, KS 66219

Fax: (760) 930-2212 E-mail: [email protected] Web site: www.syntron.net President: James P. Lee, Ph.D. Research director: James P. Lee, Ph.D. R&D expertise: Biomedical devices development and manufacture, specialization in the area of one step rapid test. Technological expertise: PA, C/TC, D-D, H/CF Principal products/instrumentation: Contract manufacturing biomedical derives, pregnancy

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test, ovulation test, drug of abuse test, drug check, drug scan. Main products/instrumentation under R&D: Therapeutic drug for treatment of tuberculosis, clinical; troponin I, clinical; one step rapid test for pregnancy, biomedical devices.

megakaryocyte progenitors, hematopoietic stem cell, autologous gene-modified hematopoietic stem cells (genetherapy) to treat HIV infection, Phase II/III. Subsidiary bodies: Paris, France.

2689 2687

SYRACUSE BIOANALYTICAL, INC.

TACONIC BIOTECHNOLOGY

Add: One Hudson City Centre Hudson, NY 12534

Add: 95 Brown Rd Ithaca, NY 14850-1294

Tel: (518) 697-3900

Tel: (607) 266-0609

Fax: (518) 697-3905

President: Roy Huchzermeier, Ph.D.

E-mail: [email protected]

R&D expertise: R&D and manufacture of immunoassay products.

Web site: www.taconic.com

Key license and trade contracts: Cornell Research Foundation, INC.: monoclonal antibodies; Ohio State University Research Foundation: monoclonal antibodies.

Research director: Ronald Russians, Ph.D.

Technological expertise: PA, P/S, H/CF

Key license and trade contracts: Strategic BioSolutions — monoclonal antibody production.

Main products/instrumentation under R&D: Contract research/clinical trial products, several diagnostic test kits for veterinary viral detection in clinical phase of development and being field tested, monoclonal antibodies.

2688

SYSTEMIX, INC.

Add: 3155 Porter Dr. Palo Alto, CA 94303

President: Todd Little, Managing Director R&D expertise: Development and production of monoclonal antibody, molecular analysis, research animal breeding services.

Technological expertise: P/S, BA, C/TC, CH/SGA, H/CF, AB Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trials products. Main products/instrumentation under R&D: Monoclonal antibodies, improved research animals.

Tel: (415) 856-4901 President: Linda Sonntag, Ph.D. Research director: Ronald Hoffman, M.D. R&D expertise: R&D and manufacture of cellular processes/products to harness therapeutic potential of hematopoietic stem cells, megakaryocytes and megakaryocyte progenitors. Technological expertise: Q, E, GT, P/S, H/CF, C/TC, PMC, CH/S Main products/instrumentation under R&D: Stem cell growth factor, megakaryocytes,

2690

TAENSA, INC.

Add: 26 Sherman Ct., Fairfield, CT 06824 Tel: (203) 256-0460 Fax: (203) 256-0464 E-mail: [email protected] President/CEO: Edgar R. Butts, Ph.D. R&D expertise: Manufacture, acquisition and commercialization of biopesticides and lowrisk pesticides.

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Key license and trade contracts: Bayer AG, FZB Biotechnik GmbH, Mississippi State University. Technological expertise: OC, SMC, CS Main products/instrumentation under R&D: Metarhizium anisopliae Strain F52; submitted for EPA registration; Bacillus subtilis Strain FZB24; 4-Allyl Anisole; biopesticides, lowrise pesticides. Subsidiary bodies: Monheim, Germany; Windsor, Colorado.

2691

TAG COPENHAGEN A/S

Add: Symbion Science Park Fruebjergvej 3 DK-2100 Denmark Tel: (45) 3917-9707

843

Fax: (886) 2-2692-4255 President: Bert Huang Research director: Calvin Chang R&D expertise: R&D and production of reagents and instruments for hospital and research institutes. Technological expertise: AB, BME Principal products/instrumentation: HLA antibody; reader and washer; Microtech; ELISA. Main products/instrumentation under R&D: Reagents and instruments for clinic and research use.

2693

TAKARA SHUZO CO., LTD.

E-mail: [email protected]

Add: 20 Naginatahoko-cho, Shijo-dori Karasuma Higashi-iru, Shimogyo-ku, Kyoto 600-8688, Japan

Web site: www.tagc.com

Tel: (075) 241-5110

President: Jakob Ross-Petersen

Fax: (075) 211-6385

R&D expertise: Research and production of DNA synthesis; DNA sequencing; peptide synthesis.

Web site: www.takarashuzo.co.jp

Fax: (45) 3917-9747

Technological expertise: Q, PIS, PS, PPAT, PI, P/PS Principal products/instrumentation: Contract manufacturing DNA, human genome project, DNA-primers, DNA mini-primers, software for DNA manufacturers, sequential. Main products/instrumentation under R&D: DNA synthesis technologies, peptide synthesis technologies.

2692

TAIWAN EVERLIGHT TRADING CO., LTD.

Add: Floor 13-3, No. 25,Lane 169, Kang Ning St. Hsi Chih, Taipei Taiwan Tel: (886) 2-2695-7733

President: Ikunoshin Kato, Ph.D. Research director: Ikunoshin Kato, Ph.D. R&D expertise: Research of gene therapy, healthy food, research reagents and instruments, immunotherapy, plant biotechnology and glycobiology; custom research service; related products development/manufacture. R&D collaboration: Indiana University — efficient gene transfer method for gene therapy. Key sales market contracts: BioWhittaker Europe — molecular biology research reagents; China Meheco Pharmaceuticals and Chemicals IMP & EXP Corp. — cancer diagnostic reagent; BioWhittaker — bioproducts; Novagen, INC. — molecular biology research reagents; Lark Technologies, INC. — contract DNA sequencing; Pan Vera Corp. — biomedical research reagents; Perkin-Eimer JapanSciex Corps LC/MS and LC/MS/MS systems;

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Strategic Diagnostics, INC. GMO tests, Generic MicroSystems — DNA microarray systems; Qualicom — RiboPrinter; Cepherd — SmartCycler. Key license and trade contracts: HoffmannLa Roche, INC. — Roche Molecular Systems, INC. — PCR-related products; Indiana University — efficient gene transfer method for gene therapy; Eli Lilly and Co. — antifungal agent; Washington University School of Medicine — LA technology and Klen Taq. Technological expertise: E, PA, AF, AB, CB, C/TC, CH/S, GA, GT, H/CF, PIS, P/S, RD Principal products/instrumentation: Deosparin (immunosuppressive agent); UFC (Urinary Free L-Fucose) test kit (tumor marker); reagents and instruments for genetic engineering, protein engineering, immunology and glycobiology research; enzymes for diagnostic use; genetic analysis computer software; DNA amplification system; genomic DNA extractor; LC/MS and LC/MS/MS systems; BEACON (Fluorescence polarization system); FMBIO (Fluorescent Method Bio Image Analyzer); GlycoTAG, PALSTATION (carbohydrate analysis system); custom services- DNA synthesis, DNA sequencing, peptide synthesis, peptide sequencing, production of antibodies, and carbohydrate analysis; RetroNectin (recombinant human fibronectin fragment for enhancing gene transfer); Apoidan-U, Tong Onion, Tong Tea (healthy drink); pDON-AI (retroviral vector); AgarGel Drink (healthy drink containing natural “Agaro-oligosaccharide”); TOWADA (emollient lotion).

improving retroviral-mediated gene transfer utilizing molecules, or mixture thereof, containing retroviral binding domains and target cell binding domains. 6,426,042, U.S.; Biologically pure culture of Fucoidanobacter marinus SI-0098(FERM BP-5403). 6,379,947, U.S.; Polypeptides for use in generating anti-human influenza virus antibodies. 6,337,070, U.S.; Method for effecting site-directed mutagenesis. 6,448,048, U.S.; Ultrathermostabel protease genes, 6,261,822. U.S.; Gene regulating aureobasidin sensitivity. 6,693,174, U.S.; Regulation of aureobasidin sensitivity in fungus. 6,348,577, U.S.; Gene transfer method with the use of serum-free, 6,287,864, U.S.; Methods of producing agmatine and arginine decarboxylace.U.S. patent; Methods for treating ulcers and gastroesophageal reflux disease. U.S. patent; Gene transfer methods. 20080044903, U.S.

2694

TAL TECHNOLOGIES, INC.

Add: 2101 Brandywine Street, Suite 102 Philadelphia, PA 19130 Tel: (215) 496-0222 Fax: (215) 496-0322 E-mail: [email protected] Web site: www.taltech.com President: Thomas A. Lutz Research director: Susan Rogers R&D expertise: Software development and production.

Main products/instrumentation under R&D: Gene therapy, health food, research reagent and instruments, 1Ab gene transfer methods, cancer diagnostic reagent, antifungal agent, efficient gene transfer method for gene therapy, DNAmicroarray systems.

Technological expertise: BME, BTS, CH/S.

Sealed and granted patents: Gene transfer methods.6,787,359, U.S.; Methods and kits for

Main products/instrumentation under R&D: Software for collecting data from instrumentation.

Principal products/instrumentation: Data collection software for instrumentation, Software Wedge, Windows-based data acquisition software. Windows 95 & NT data acquisition software, Barcode Software.

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TANOX, INC.

2696

845

TARGESOME, INC.

Add: 10555 Stella Link, Houston, Texas, TX 77025

Add: 4030 Fabian Way Palo Alto, CA 94303

Tel: (713) 578-4000

Fax: (650) 842-1828

Fax: (713) 578-5000

President/CEO: Roderick Young

President/CEO: Nancy T. Chang, Ph.D.

Research director: Mark Bednarski, Ph.D.

Research director: Dr. David Thomas

R&D expertise: Research and production of developing imaging and therapeutic agents based on angiogenesis.

R&D expertise: R&D and manufacture of biopharmaceutical products for treatment of diseases and disorders affecting the human immune system.

Tel: (650) 842-1820

Technological expertise: COC, DD, GA, GT

R&D collaboration: Ciba-Geigy Ltd., antiHTV neutralizing MAb therapeutics and antiIgE MAb products for treating certain allergies.

Main products/instrumentation under R&D: Angiogensis imaging radiopharmaceutical, preclinical; anti-angiogenesis therapy, preclinical; targeted polymerized liposome diagnostic and treatment agents.

Key license and trade contracts: Takara Shuzo, Co, Ltd — licensing rights in Japan and Korea for migis — mIgA for use in treatment of IgA nephropathy.

Sealed and granted patents: Polymerized liposome; targeted polymerized liposome diagnostic and treatment agents, 350,466, U.S.

Technological expertise: Q, P/S, C/TC, D-D, H/CF, RD, AB Main products/instrumentation under R&D: AL-901 (anti-IgE antibody), Phase IIIa; AD439 (anti-HTV antibody), Phase II/III; AD-519 (anti-IgE antibody), Phase II/III; migis-mlgA (IgA nephropathy), research; migis-mlgG (anti-IgE secreting B cells), research; anti-HTV neutralizing MAb therapeutics, anti-IgE-MAb therapeutics, other biopharmaceuticals. Sealed and granted patents: Inhibition of complement activation. 7,112,327, U.S.; Apoptosis-modulating proteins, DNA encoding the proteins and methods of use thereof. 7,108,989, U.S.; Bak promoter expression system. 6,436,639, U.S.; Bak binding protein, DNA encoding the protein, and methods of use thereof. 6,441,135, U.S.; Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof. 6,433,155, U.S.; other patents are pending.

2697

TARGETED GENETICS CORP.

Add: 1100 Olive Way, Suite 100 Seattle, WA 98101 Tel: (206) 623-7612 Fax: (206) 223-0288 Web site: www.targen.com President/CEO: H. Stewart Parker Research director: Barrie J. Carter, Ph.D. R&D expertise: Research of gene and cell therapies, related novel products development and manufacture. R&D collaboration: Groupe Fournier; Pasteur Merieux Key license and trade contracts: MD Anderson Cancer Center, Fred Hutchinson Cancer Center, University of Pittsburgh. Technological expertise: C/TC, DD, GT Main products/instrumentation under R&D: tg-AAV-CFTR, gene therapy for sinusitis and

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cystic fibrosis, Phase II/III; tg-DCC-ElA, gene therapy for cancer, Phase II; Targeted CTLS, cell therapy for infectious disease, Phase II/III.

2698

TASC,INC.

Add: 55 Walkers Brook Dr. Reading, MA 01867-3297

Principal products/instrumentation: KSeries Cryostorage Systems, Mark III controller, variety of refrigerators, dewars, freezers, dry shippers. Main products/instrumentation under R&D: Novel cryogenic storage equipment.

2700

TC ASSOCIATES, INC.

Tel: (781) 942-2000 Fax: (781) 942-7100

Add: P.O. Box 285 West Boxford, MA 01885

President: John C. Holt

Tel: (978) 352-7047

Research director: Donald S. Masters, Ph.D.

Fax: (978) 352-7047

Subsidiary of Primark Corp.

E-mail: [email protected]

R&D expertise: Development of applied information technology for biopharmaceutical research.

Web site: tcaonline.com

Technological expertise: CH/S, RPP, P/PS Main products/instrumentation under R&D: Protein classification techniques; advanced imaging techniques; applied information technology for biopharmaceutical research. Subsidiary bodies: Reston, VA; Arlington, VA; Dayton, OH.

2699

TAYLOR-WHARTON CRYOGENICS

Add: 4075 Hamilton Blvd. Theodore, AL 36582 Tel: (251) 443-8680 Fax: (251) 443-2209 E-mail: [email protected] Web site: www.taylorwharton.com President: Ronald W. Kaplan Research director: John Wimberley Subsidiary of Harsco Corp. R&D expertise: Development and manufacture of cryogenic storage equipment Technological expertise: BME

President: Richard F. Taylor R&D expertise: Management discovery, development and technology consulting in the life sciences and biotechnology research. Technological expertise: PA, RD, PG, PMC, P/S, BA, COC, D-D, GA, GT Principal products/instrumentation: Biosensors, diagnostics, instruments, enzymes, antibodies, nutraceuticals, vaccines, reagents, and other biopharmaceuticals.

2701

TCPI, INC.

Add: 3333 SW 15th Str. Pompano Beach, FL 33069 Tel: (954) 979-0400 President: Elliott Block, Ph.D. Research director: Thomas Hunter, Ph. D. R&D expertise: R&D and manufacture of rapid diagnostics, specialty biochemicals, drug delivery technology, skin permeation enhancers, etc. Technological expertise: PA, DD Principal products/instrumentation: Contract manufacturing products, RIS, Health

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Clock Diagnostic Test Kits, SR-38 Skin Permeation Enhancer.

President: Greg Buckley

Main products/instrumentation under R&D: Estradiol, clinical trials, for treatment of Bub4, incontinence; rapid diagnostics, specialty biochemicals, skin permeation enhancers.

R&D expertise: Research, design and production of innovative cell culture consumables.

Sealed and granted patents: 28 U.S. and foreign patents held.

2702

TCS BIOSCIENCE LTD

Add: Botolph Claydon Buckingham MK18 2LR U.K. Tel: (44) 1296-714-222

Research director: Thomas J. Murphy

Technological expertise: C/TC, BA, BME Principal products/instrumentation: SICULTURE™ silicone cell culture growth bags, flexible cell culture media bags, custom fluid transfer systems, liners for Nalgene Tanks, cell culture consumables.

2704

TEBU-BIO

Fax: (44) 1296-714-806

Add: 39 Rue de Houdan — BP 1578612 Le Perray en Yvelines Cedex France

E-mail: [email protected]

Tel: (33) 1-3046-3900

Web site: www.tcsbiosciences.co.uk

Fax: (33) 1-3046-3911

President: Dr. A.E. Preston

E-mail: [email protected]

R&D expertise: R&D and production of research tools and reagents in biotechnology and cell biology.

Web site: www.tebu-bio.com

Key sales market contracts: Upstate Biotechnology, INC., Clonetics, INC., Biosoft, Tago, INC., Biognostik GmbH, Endogen, INC. Technological expertise: TE, PA, P/S, BA, H/CF, HTDS, C/TC, AB, BME, CW Principal products/instrumentation: Biologicals, contract manufacturing products, in vitro toxicology testing method, pharmaceuticals, reagents. Main products/instrumentation under R&D: Drug research tools, reagents for biotechnology and cell biology research.

2703

TC TECH CORP.

Add: 5475 Pioneer Creek Drive Maple Plain, MN 55359 Tel: (763) 479-0799 Fax: (763) 479-0862

President: J. E. van Dijk Research director: D. Lecommandeur, Ph.D. R&D expertise: Manufacture and supply of research reagents for European market. Technological expertise: PA, Q, C/TC, H/CF, P/S Principal products/instrumentation: Reagents. Subsidiary bodies: Sanvertech, A. Tebu Co., Hovesesteenweg 132, Boechout, Belgium; TEBU GmbH, Stadelstrasse 10, D-60596, Frankfurt/Main Germany; SanverTECH bv, Beveiandseweg 28, NL-1703 AZ Heerhugowaard, Netherlands; TOTAM Biologicals Ltd., Beckett House, 14 Billing Rd., Northampton, NN1-5AW, U.K., Trimitel, via Pretorm, 41-20013 Magenta, Italy.

2705

TECAN GROUP LTD.

Add: Seestrasse 103 CH-8708 Männedorf, Switzerland

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Tel: (41) 44-922-8111 Fax: (41) 44-922-8112 E-mail: [email protected]

Main products/instrumentation under R&D: Novel biotechnology software, automated instruments for sample preparation.

Web site: www.tecan.com CEO: Dr. Emile C. Sutcliffe

2707

TECHLAB, INC.

Research director: Martin Dubs R&D expertise: Laboratory automation research. Key sales market contracts: Abbott Technological expertise: Q, BA, P/S, GA, CH/S, COC, HTDS, SY, G, SY Principal products/instrumentation: TRAC (Tecan robotic assay composer), Tecan RSPs (Robotic sample processors), spectrafluor (microplate fluorescence), spectra (microplate photometer), Chem System (combinchemistry) ULTRA genesis workstation (multilabel MTP ready).

Add: 2001 Kraft Drive Blacksburg, VA 240606358 Tel: (540) 953-1664 Fax: (540) 953-1665 E-mail: [email protected] Web site: www.techlab.com President: Dr. Tracy Wllkins Research director: Dr. David Lyerly R&D expertise: R&D and manufacture of difficile toxin/antitoxin, and products testing method. Technological expertise: PA, RD, C/TC, P/S

2706

TECAN U.S., INC.

Add: 4022 Stirrup Creek Drive Suite 310 Durham NC 27703 Tel: (919) 361-5200 Fax: (919) 361-3601 E-mail: [email protected] Web site: www.tecan.com President: Carl Severinghaus R&D expertise: R&D of biotechnology software, automated instrumentation for sample preparation, microplate, photometry, fluorescence, luminescence and microplate washing. Technological expertise: COC, HTDS, R, G, BME Principal products/instrumentation: Robotic Sample Processors — Genesis Series, Robotic Workstations; Fluorescence MTP Readers — Spectra Series, Microplate Washers — 96PW, Columbus; Robotic Microplate Processors, Facts/Gemini software package.

Principal products/instrumentation: T5001C. difficile Tox-A Test; T5002-Leuko Test; T5003-C. difficileTox-B Test; T5004-Entamoeba test; T5015-C. Difficile Tox-A/B Test; T5000- C. dificileToxin/Antitoxin Test; T5012Giardia Test; T5014-Cryptosporidium Test; T5005 — E. histolytica Test; T5006 — C. perfringens Test Main products/instrumentation under R&D: Difficile toxin/antitoxin testing methods. Sealed and granted patents: Methods to produce high levels of C. difficile toxins, 6,939,548, U.S.

2708

TECHNALLTHICS LABORATORIES, INC.

Add: 217 Schroeder Dr. Waco, TX 767106962 Tel: (817) 776-7994 Fax: (817) 776-7995 E-mail: [email protected]

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President/CEO: Stephen C. Scott, Ph.D. Research director: David Groce R&D expertise: Contract laboratory instrumentation, research, product design and development/manufacture, testing and analysis; integrated networks. Joint ventures: KPL, Millipore, SmithKline. R&D collaboration: Millipore, SmithKline, Kirkegaard & Perry Labs, GLG Energy.

Main products/instrumentation under R&D: Biotechnology medicines, biomedical laboratory equipment.

2710

TECHNE, INC.

Add: 3 Terri Lane, Suite 10 Burlington, NJ 08016 Tel: (609) 589-2560

Key sales market contracts: Biotect Licensing

Fax: (609) 589-2571

Key license and trade contracts: Huck International, KPL.

E-mail: [email protected]

Technological expertise: F, Q, BA, H/CF, C/TC, DMC, CH/S, BME

President: Neil Pope

Principal products/instrumentation: Densitometer, colorimeter, process control lab instruments, radiation monitor/data logger. Main products/instrumentation under R&D: Single beam spectrophotometer, CO2 entrapment system, scanning densitometer.

2709

BIBBY SCIENTIFIC LIMITED

Add: Beacon Road, Stone, Staffordshire ST15 0SA, U.K.

849

Web site: www.techneusa.com Research director: Darren Sager R&D expertise: Development and manufacture of laboratory instruments for drug research use. R&D collaboration: Yale University. Technological expertise: F, Q, GA, GT, H/CF, R, BME Principal products/instrumentation: Water baths and circulators, heating blocks, thermal cyclers/hybridizers, spectophotometers, flame photometers, electrochemistry meters, Spectrophotomer, 2007; Synthesizer columns, 2007.

Tel: (44) 1785-812-121 Fax: (44) 1785-810-405 E-mail: [email protected]

2711

TECHNICAL CHEMICALS & PRODUCTS, INC.

Web site: www.techne.com President: AG. Harris Research director: P. Windle R&D expertise: Research of biomedical laboratory equipment and biotechnology medicines, related products development and manufacture. Technological expertise: Q, GT, RD, GA, C/TC, BME Principal products/instrumentation: Cell culture stirrers, thermal cyclers, hybridization, incubators.

Add: 33415W 15th St. Pompano Beach, FL 33069-4808 Tel: (954) 979-0400 President: Jack L. Aronowitz R&D expertise: Development and production of specialty chemicals, professional and home diagnostic tests. Technological expertise: CS, BME, CB Principal products/instrumentation: Healthcheck Brand Home Diagnostic Tests; TRIS Ultrapure; TRIS HCL; TRIS Trycine.

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Main products/instrumentation under R&D: Transdermal glucose, clinical; specialty chemicals. Sealed and granted patents: Over 25.

2712

TECHNICAL INSTRUMENTS

E-mail: [email protected] Web site: www.technically.com President/CEO: Debra J. Saez, Ph.D. R&D expertise: Research of cGMP custom chemical synthesis, manufacturing and development of fine and specialty organics, pharmaceutical intermediates, biologically-active molecules.

Add: 1826 Rollins Road Burlingame, CA 94010-2200

Technological expertise: CC, COC, D-D, PIS, P/S, SMC, SY

Tel: (650) 651-3000

Principal products/instrumentation: Agriculture, biologicals, biomaterials, specialty chemicals, contract manufacturing products, natural products, pharmaceuticals.

Fax: (650) 651-3001 E-mail: [email protected] Web site: www.techinst.com President/CEO: Francis E. Lundy Research director: Horst Groneberg R&D expertise: R&D and production of industrial and biological microscopes and accessories. Joint ventures: Danish Micro Engineering of Denmark R&D collaboration: General Nanotechnology. Key sales market contracts: Nikon, INC.; Instrument Group.

Main products/instrumentation under R&D: cGMP custom chemical synthesis, pharmaceutical intermediates, biologically-active molecules.

2714

TECHNIKROM, INC.

Add: 1855 Elmdale Avenue Glenview, IL 60026 Tel: (800) 865-4100

Key license and trade contracts: Stanford University.

Fax: (800) 293-5059

Technological expertise: R, BME

Web site: www.tecknikrom.com

Principal products/instrumentation: BRITE Confocal Laser Scanning Microscope, K2SBio Confocal Scanning Optical Microscope, AUMI Automated Computerized Microscope.

President: Lou Bellafiore

Main products/instrumentation under R&D: Industrial and biological microscopes.

E-mail: [email protected]

Research director: Kevin Henretta R&D expertise: R&D and manufacture of chromatography and bioprocess engineering equipment, peptides and peptide instrumentation, etc. Joint ventures: Dan-Process A/S.

2713

TECHNICALLY, INC.

Add: 155-B New Boston Street Woburn, MA 01801 Tel: (781) 376-1587 Fax: (781) 376-1584

Technological expertise: CC, F, PI, CS, BP, PMC, PIS, LP, BA, P/S, SY, PS, HC Principal products/instrumentation: Buffer Dilution Systems, 2008; Dan-Process™ HPLC and LPLC dynamic axial compression industrial scale columns, automated HPLC and LPLC skid systems, automated peptide synthesizers,

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automated fermenters, microfiltration and ultrafiltration systems; Buffer Dilution Systems: Two next-generation IBD™ In-line Buffer Dilution skid systems utilize PAT™ technology for in-line dilution of buffered salt solution concentrates at 300 L/hr and 1200 L/hr throughput. 2009; Buffer Dilution Systems: Two nextgeneration IBD™ In-line Buffer Dilution skid systems utilize PAT™ technology for in-line dilution of buffered salt solution concentrates at 300 L/hr and 1200 L/hr throughput. Buffer dilutions of up to 10–15X can be achieved with concurrent pH adjustment, 2009.

Fibronectin, preclinical; Teststicks PAI-1, preclinical; protein separation/purification technologies.

Main products/instrumentation under R&D: Bioprocess engineering equipment.

President/CEO: Andrew Zaayenga

Subsidiary bodies: Evanston, IL, U.S.A., Oak Lawn, IL 1529 Elmwood mette, IL 60091 and 4601 W.SW Highway, IL 60453

R&D expertise: Development and production of laboratory automation research robotics.

2715

TECHNOCLONE GMBH

Add: Brunner Str. 59/5 1230 Vienna Austria Tel: (43) 1-863-730 Fax: (43) 1-863-7344 E-mail: [email protected] Web site: www.technoclone.com President: Prof. Dr. Bernd R. Binder

2716

HAMILTON STORAGE INC.

Add: 103 South Street Hopkinton, MA 01748 Tel: (508) 544-7000 Fax: (508) 544-7001 E-mail: [email protected] Web site: www.hamilton-storage.com Research director: Julian Warhurst

Joint ventures: Becton Dickinson, SealTite Microplate Cover. Technological expertise: S, GN, HI, X Principal products/instrumentation: Assay Tekbench™, Plateserv-er™, Platestore™, SealTite Microplate Cover™. Main products/instrumentation under R&D: Replication Tekbench, automation research robotics. Sealed and granted patents: SealTite and mechanism for sealing.

Research director: Margaret Griffiths R&D expertise: Development and manufacture of cell/tissue culture, protein purification/ separation, monoclonal/polyclonal antibodies and other biotechnology diagnostic products.

2717

TELEDYNE TEKMAR

Add: 4736 Socialville Foster Road Mason, Ohio OH 45040

R&D collaboration: American Diagnostica U.S.A.

Tel: (513) 229-7000

Technological expertise: PA, Q, TE, T, BS, C/TC, GT, H/CF, MAE, RPP, RD, P/PS, PC

E-mail: [email protected]

Principal products/instrumentation: Assay kits, Tissue culture, Purified proteins, Monoclonalpolyclonal antibodies. Main products/instrumentation under R&D: Teststicks t-PA, clinical/Phase II; Teststicks

Fax: (513) 229-7050 Web site: www. teledynetekmar.com President: Dr. David Kennedy Research director: Ron Uchtman R&D expertise: R&D and manufacture of environmental protecting products.

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Technological expertise: C/TC, BME

Technological expertise: CH/S, BME

Principal products/instrumentation: 3000 Purge and Trap Concentrator, Precept Robotic Vial Autosampler, AEROTrap 6000 Thermal Desorber, 7000 Headspace Autosampler, Phoenix 8000 UV Persulfate TOC Analyzer, tissue homogenizers, ultrasonic disrupters, stirrers, sample bags.

Principal products/instrumentation: Aspen LIMS, A 32-bit client/server windows-based LIMS (Laboratory Information Management System), furnishing of sample and QC/QA tracking, data import and export report generation, graphical representation, Internet awareness and more; conifer LIMS.

2718

TEKTAGEN, INC.

2720

ARRAYIT CORPORATION

Add: 358 Technology Dr. Malvern, PA 193551315

Add: 524 East Weddell Drive #3 Sunnyvale, CA 94089

Tel: (610) 640-4760

Tel: (408) 744-1331

President/CEO: Thomas Perm

Fax: (408) 744-1711

Research director: Barbara Smallwood

E-mail: [email protected]

R&D expertise: Full range services of QC testing to biopharmaceutical companies.

Web site: www.arrayit.com

Key sales market contracts: Anawa Laboratories, Zurich, Switzerland; Iwaki Glass Co., Tokyo, Japan.

R&D expertise: R&D of microarray technology, novel products manufacture.

Technological expertise: Q, RD, GA, C/TC, PMC

Principal products/instrumentation: Steath micro-spotting technology, 384 Well PCR purification, 384 well dye terminator cleanup, UniHyb™ micro-spotting solution, Hybridization Cassette, tools, kit and reagents for DNA microarrays, cleanroom/contract arraying.

Principal products/instrumentation: Process validation, vaccines, antibodies, reagents, peptides, contract research/clinical trials products, other biopharmaceuticals.

2719

TELECATION, INC.

Add: 7112 W.Jefferson Avenue, Ste. 307 Lakewood, CO 80235

President: Rene A. Schena

Technological expertise: BME, P/P, SSMSA

Main products/instrumentation under R&D: Microarray technology, chipmaker microspotting technology. Sealed and granted patents: Filed for protection on ChipMaker micro-spotting technology.

Tel: (800) 584-9964 Fax: (505) 994-3574 Web site: www.telecation.com President: Leigh A. Richardson R&D expertise: R&D and manufacture of biotechnology software, including laboratory information management for analytical, research.

2721

TELIK, INC.

Add: 3165 Porter Drive, Palo Alto, CA 94304 Tel: (650) 845-7700 Fax: (650) 845-7800 E-mail: [email protected] Web site: www.telik.com

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President: Michael M. Wick, M.D., Ph.D. Research director: Michael M. Wick, M.D. Ph.D.

853

R&D collaboration: Eli Lilly and Co. — osteoporosis.

R&D expertise: Discovery, research and development of human therapeutics; research and development of biotechnology medicines.

Key license and trade contracts: Ono Pharmaceutical (Japan, South Korea, Taiwan) — Decorin; St. Jude Medical — PepTite™ for heart valves.

R&D collaboration: Sanwa Kagaku Kenkyusho — diabetes; Taiho — TER286.

Technological expertise: C/TC, SY, D-D, PS, P/PS, PS/AP

Technological expertise: COC, D-D, H/CF, AF, CH/S, PMC

Main products/instrumentation under R&D: Argidene™ gel, dermal wound healing; PMA filed for diabetic ulcers; OcuNex™, treat severe dry eye, Phase II; TP-9201, platelet aggregation inhibitor, preclinical; Peptite™, biocompatible coating, preclinical; Decorin, for treatment of fibrotic diseases, preclinical; osteoporosis peptides for treatment of osteoporosis.

Main products/instrumentation under R&D: RP12, insulin receptor agonist, R&D; TER286, cytotoxic agent prodrug, oncology, R&D, preclinical; TER199, orally active myelostimulant, oncology, R&D, preclinical; TER286, cytotoxic agent, oncology, preclinical; TER199, myelostimulant, oncology, preclinical; Insulin sensitizer for treatment of diabetes, preclinical; other biotechnology medicines. Sealed and granted patents: Bone marrow stimulation by certain glutathione analogs, U.S. patent #5,767,086; Method for analyte classification by SC profiles, U.S. patent #5,674,688; Therapeutic compositions containing glutathione analogs 7,029,695 U.S.; other patents are pending.

2723

TELLURIDE PHARMACEUTICAL CORP.

Add: 300 Valley Rd. Building 278 Hillsborough, NJ 08876-4059 Tel: (908) 369-1800 Fax: (908) 369-1331 E-mail: [email protected]

2722

TELIOS PHARMACEUTICALS, INC.

President: Dr. Thomas M. Kenyhercz Research director: Dr. Ellen J. Crane

Fax: (619) 535-8269

R&D expertise: R&D, manufacture and commercialization of natural source-based pharmaceuticals, biological products of collagen-based delivery systems, aerosol and topical vaccines licensed from the former USSR.

President/CEO: Donald W. Grimm

Technological expertise: BME, CB, COC

Research director: Michael D. Pierschhacher, Ph.D,

Main products/instrumentation under R&D: Cachexon capsules, SEMOV capsules, ANOSTE capsules, MEMEX tablets, MEMEX-P tablets, natural source-based pharmaceuticals, biological products of collagenbased delivery systems.

Add: 2909 Science Park Road, San Diego, CA 92121 Tel: (619) 452-6180

R&D expertise: R&D and manufacturing of a new class of therapeutic products that modify or mimic extracellular matrix functions in tissue repair and disease.

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TEL-TEST, INC.

Add: P.O. Box 1421 Friendswood, TX 775491421 Tel: (281) 482-2672

endogen; IHC antibodies, Eurodiagnostica, Endocrinology, RIA and EIA kits, Phoenix Pharmaceuticals.

2726

TEPNEL LIFE SCIENCES PLC

Fax: (281) 482-1070 E-mail: [email protected] Web site: www.tel-test.com President: Thomas Maloney Research director: Lawrence C Starke, Ph.D. R&D expertise: R&D and manufacture of DNA/ RNA isolation products, custom iodinations.

Add: 12 Blacklands Way Abingdon Business Park, Abingdon. Oxon. OX14 1DY, U.K. Tel: (44) 1235-544-220 Fax: (44) 1235-544-222 E-mail: [email protected] Web site: www.tepnel.com

Technological expertise: P/S, PPAT, P/PS, RPP, PC

President: Dr. Peter Raymond, Chairman

Principal products/instrumentation: Contract manufacturing pharmaceuticals, RNAzol B, RNA-Stat 60, DNA Stat-60.

R&D expertise: DNA analysis research, primarily within the area of nucleic acid purification, related products manufacture.

Main products/instrumentation under R&D: ISO-Clear, non-phenolic technique to purity proteins from solutions of DNA/RNA; Bio-De “R”, non phenolic method to isolate RNA, DNA/RNA isolation products.

Technological expertise: Q, COC, CH/S, P/S, GA

2725

TEMA RICERCA SRL

Add: Via Savena Antico 9/A Bologna 40139 Italy Tel: (39) 51-624-0700 Fax: (39) 51-624-0706 E-mail: [email protected] Web site: www.temaricerca.com

Research director: Peter Highfield

Principal products/instrumentation: Nucleon range of kits; Automated systems for plasmid; DNA purification and the purification of genomic DNA from blood for nucleic acid purification, nucleon nucleic acid purification service, GIP accredited analytical services. Main products/instrumentation under R&D: Micro-bead DNA technology for the capture detection and amplification of DNA and RNA, R&D; DARAS™ (DNA and RNA analysis system). Sealed and granted patents: Patented microbead technology.

President: Marina Gialloreto Research director: Pasqualina Bovenzi R&D expertise: R&D and marketing of biomedical and diagnostics products. Technological expertise: PA, AB, RPP, P/PS, PPAT Principal products/instrumentation: Cytokines — ELISA kits, antibodies, rec. proteins,

2727

TERECON CORPORATION

Add: 567 Liberty Lane West Kingston, RI 02892 Tel: (401) 782-0014 Fax: (800) 598-5747 E-mail: [email protected]

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President: Joseph Concordia

Tel: (604) 221-8896

R&D expertise: BioChemicals manufacture.

Fax: (604) 221-8881

Joint ventures: Eastar Chemical Co. R&D

Web site: www.terragen.com

Key sales market contracts: GLSynthesis, INC.; SLI Technologies Corp.

President: Mario Thomas, Ph.D.

Key license and trade contracts: Eastar Chemical Co.

Research director: Stephen Wrigley, Ph.D.

Technological expertise: CC, SMC, SY Principal products/instrumentation: 3Bromo Quinoline, Biologicals, specialty chemicals, reagents Main products/instrumentation under R&D: Novel biochemicals.

CFO/CEO: Julian Davies, Ph.D. R&D expertise: R&D of combinatorial biology drug lead discovery, using recombinant genetics, and non-cultivable microbes prospected for pharmaceutical agents, etc. R&D collaboration: Major pharma and biotechnology companies to screen libraries of novel clones and discover leads. Technological expertise: Q, P/S, AF, GA, BA, HTDS, RD, R, SMC, PMC

2728

TERRACELL INTERNATIONAL S.A.

Add: Chateau de Vaumarcus Vaumarcus CH2028 Switzerland Tel: (41) 32-836-3628 Fax: (41) 32-836-3629 President: Paul Haffenden, General Manager R&D expertise: Development, manufacture and supply of animal sera, cell culture reagents, and cell culture automation technology. Joint ventures: Contract manufacturing and marketing; CANSERA INTERNATIONAL, INC. Key sales market contracts: With Gallon for Rollen Cell Technology, Rollen Cell System.

Principal products/instrumentation: NatChem™, NatGen™, NatPure™, NatGold™. Main products/instrumentation under R&D: Combinatorial biology drug, isolation method of biosynthesis genes. Subsidiary bodies: Terragen Discovery U.K. Ltd. Sealed and granted patents: Signal transduction screen, isolation methodology, novel compounds (~2001); Method for isolation of biosynthesis genes for bioactries molecules. 6,297,007, U.S.; Method for isolation of xylanase gene sequences from soil DNA, compositions useful in such method and compositions obtained thereby. 6,441,148, U.S.; other patents are pending.

Technological expertise: C/TC, BA Principal products/instrumentation: Cell Culture grade Fetal Bovine Serum; Isolated Hard Donor Bovine Serum; Rollen Cell 40, Cell Culture Automation System.

2729

TERRAGEN DIVERSITY, INC.

Add: Ste. 300 2386 East Mall (UBC) Vancouver, BC V6T 1Z3 Canada

2730

TERRA NOVA BIOTECHNOLOGY CO., LTD.

Add: 2nd Floor, Spencer Hall P.O. Box 13340 St. John’s, NF A1B 4B7 Canada Tel: (709) 737-4026 Fax: (709) 737-2101 E-mail: [email protected] President/CEO: Robert Vivian

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Research director: Dr. William Marshall

Fax: (800) 747-5171

R&D expertise: R&D and manufacture of monoclonal antibodies for in vitro diagnostic use having applications in bone-marrow transplantation matching and the diagnosis/prognosis of rheumatoid arthritis patients.

E-mail: [email protected]

Technological expertise: PA, C/TC, H/CF Principal products/instrumentation: Contract manufacturing products, contract research/clinical trial products, organ transplants/culture, Advanced monoclonal antibodies; HLA-DP for matching bone marrow donors/recipients and monoclonal antibodies for the diagnosis/prognosis of rheumatoid arthritis (RA) patients, bone marrow transplantation matching.

President: Syd Abrahams, Ph.D. R&D expertise: Research of molecular biology, immunology, related novel applied diagnostic and therapeutic products manufacture. Technological expertise: PA, RD, AB, C/TC, GA, G, H/CF, P/S Principal products/instrumentation: Calypso RT-PCR; Anti-Ox-2 antibodies; Digoxigenin labeled probes. Main products/instrumentation under R&D: Immunomodifier.

2733 2731

TEXAS BIOTECHNOLOGY CORPORATION

TERRA UNIVERSAL

Add: 800 S. Raymond Avenue Fullerton, CA 92831 Tel: (714) 578-6000 Fax: (714) 578-6020 E-mail: InfoCustomerService@TerraUniversal. com Web site: www.terrauniversal.com President: George Sadaghiani R&D expertise: Development, manufacture and supply of cleanroom and lab equipment for drug research. Technological expertise: BME, R Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, cleanser, clean circulation method.

Add: 7000 Fannin St. Suite 1920 Houston, TX 77030 Tel: (713) 796-8822 E-mail: [email protected] Web site: www.tbc.com. President/CEO: David B. McWilliams Research director: Richard A F. Dixon, PhD. R&D expertise: Applied research of rational drug design and development, novel products manufacture. R&D collaboration: IG Chern, Synthelabo, SmithKline Beecham Plc. Key sales market contracts: SmithKline Beecham Plc. Key license and trade contracts: SmithKline Beecham Plc. Technological expertise: COC, HTDS, R, SMC, SY

2732

TETRA LINK INTERNATIONAL, INC.

Add: 57 Benbro Dr. Buffalo, NY 14225 Tel: (800) 747-5170

Main products/instrumentation under R&D: Novastan® argatroban to treat heparin-induced thrombocytopenia(HIT) syndrome, NDA filed; TBC11251- PhaseI II; TBC1269, Phase II; rational drug design technology.

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2734

TEXAS FLOURESCENCE LABS

2736

TGA SCIENCES, INC.

Add: 9415 Capitol View Dr Austin, TX 787472158

Add: 47 Hall Street, Medford, MA 02155

Tel: (512) 280-5223

Fax: (781) 393-6894

Fax: (512) 280-4997

E-mail: [email protected]

President: Mark Huggans

Web site: www.tgasciences.com

R&D expertise: R&D of fluorescent and molecular probes for life science, molecular biology, high throughput cell screening and drug discovery research, related novel products manufacture.

President: Michael Settles

Technological expertise: DDI, HTDS Principal products/instrumentation: Contract manufacturing products, Fura- PE-3, Fluo 3 & 4. Main products/instrumentation under R&D: Molecular probes for drug discovery, high throughput cell screening.

2735

TEXTCO, INC.

Add: 27 Gilson Rd. West Lebanon, NH 03784 Tel: (603) 643-1471 Fax: (603) 643-1471 E-mail: [email protected] Web site: www.textco.com President/CEO: Robert H. Gross, Ph.D. R&D expertise: Development, manufacture and sales of software for molecular biologists. Technological expertise: Q, BI, CH/S, G, RD, D-D, BTS Principal products/instrumentation: Gene Inspector™, Gene Construction Kit 2™, Gene Inspector™ 1.5. Main products/instrumentation under R&D: Gene Construction Kit 2 for Windows® software for molecular biologist.

857

Tel: (781) 393-6910

Research director: Julian Bond, Ph.D R&D expertise: Contract laboratory R&D of novel drugs Technological expertise: PA, C/TC, SMC, DD, HTDS, H/CF Principal products/instrumentation: Contract research/clinical trial products, vaccines, antibodies. Subsidiary bodies: 100 Cummings Center, Ste. 430J, Beverly, MA 01915.

2737

THAI CAN BIOTECH CO., LTD.

Add: 35/3 Soi Phaholyothin 14, Phaholyothin Road, Samsenai, Phayathai, Bangkok 10400 Thailand Tel: (662) 2-290-5090 Fax: (662) 2-272-6915 E-mail: [email protected] Web site: www. thaicanbiotech.com CEO: Preeya Sribunruang R&D expertise: Development and marketing of biotechnology products. Technological expertise: CB, E, ET Principal products/instrumentation: LAL products, Food diagnostic test kits.

2738

THAR DESIGNS, INC.

Add: 730 William Pitt Way D7 Bldg 51 Oakmont, PA 15139

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Tel: (412) 435-0200 President: Lalit Chordia R&D expertise: R&D and manufacture of instrumentation and system design for SFE/SFC pilot to plant scale. Technological expertise: CC, P/S, BME, P/P, P/S Principal products/instrumentation: Contract manufacturing products, Valve actuators, high pressure vessels, pumps, back pressure regulators, systems for chiral separation, systems for separations/purification using supercritical fluid extractions. Main products/instrumentation under R&D: Instrumentation system for drug SFE/SFC pilot to plant scale.

Main products/instrumentation under R&D: Baseline-range of genomics processing modules; Liquid handling systems. Subsidiary bodies: 266 Main St., Suite 26; Medfield, MA 02052, Tel: (508) 359-5800, Fax: (508) 359-9352

2740

THE BINDING SITE, LTD.

Add: P.O. Box 11712 Birmingham B14 4ZB U.K. Tel: (44) 121-436-1000 Fax: (44) 121-430-7061 E-mail: [email protected] Web site: www.bindingsite.co.uk President: Dr. A Bradwell

2739

THE AUTOMATION PARTNERSHIP

Add: York Way Royston Hertfordshire SG8 5WY U.K. Tel: (44) 1763-227-200 Fax: (44) 1763-227-201 E-mail: [email protected] Web site: www.automationpartnership.com President/CEO: J. Richard Archer Research director: Steve Owen R&D expertise: Research and production of strategic automation solutions for life science industry research use. Technological expertise: G, R Principal products/instrumentation: Compound storage and retrieval system, Cell culture robotic system, High speed plate replicator, Automated plating attachment, 2007; Automated Stem Cell Picker: CellCelector™ is an automated stem cell picker, which consists of an inverted Olympus microscope, robotic arm, and liquid-handling station all fully integrated to image acquisition and analysis software. 2009.

R&D expertise: R&D and production of immunodiagnostic kits and reagents for use in clinical research and veterinary laboratories. Technological expertise: PA, P/S, C/TC, H, CF, PIS, AB, RPP, P/PS, PPAT Principal products/instrumentation: Contract manufacturing, diagnostics, reagents, Bindazyme, Bindarid™, Nanorid™ kits for quantitation of human and animal immunoglobulins, IgG subclasses and serum proteins; MiniFix™ immunofixation kits, Improve quality assurance schemes. Autoimmune Disease IFA and ELISA kits. Nephelometric/Tarridimetric serum protein kits. Soluble CD23 ELISA. Polyclonal/Monclonal antibodies and conjugates, purified proteins, myeloma sera. Main products/instrumentation under R&D: Immunodiagnostic kit and reagents for clinical and veterinary research. Subsidiary bodies: The Binding Site, INC., 5889 Oberlin Dr. #101, San Diego, CA 92121, Tel: (800) 633-4484, Fax: (619) 453-9189. The Binding Site GmbH, Technologic Park, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany, Tel: (49) 062-2140-9011, Fax: (49)

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062-2141-3116; The Binding Site, WTC BP1510. PL Robert Schuman 38025, Arenoble, Cedex 1.

2741

THE GRIEVE CORP.

Add: 500 Hart Rd. Round Lake, IL 600732898 Tel: (847) 546-8225 Fax: (847) 546-9210 E-mail: [email protected] Web site: www.grievecorp.com President: P. J. Calabrese Research director: Doug Grieve R&D expertise: Development and manufacture of laboratory cleanroom, pharmaceutical ovens to furnaces.

and certain other Southeast Asian countries; Roemmers S.A. — HIV for Latin America. Technological expertise: Q, C/TC, DD, GT Main products/instrumentation under R&D: HIV immunotherapeutic Remune, Phase III/IV clinical trials; rheumatoid arthritis therapeutic vaccine, Phase III clinical trials; multiple sclerosis therapeutic vaccine, Phase II; psoriasis, Phase II/III; gene therapy, preclinical; hepatitis B, hemophilial A and atherosclerosis therapeutics, cancer therapy; colon therapeutics, Phase I; and prostate, preclinical. Sealed and granted patents: Key patents received in both U.S. and/or international in HIV, autoimmune disease, gene therapy and cancer therapy.

2743

Technological expertise: BME Principal products/instrumentation: Pharmaceuticals/biopharmaceuticals, cleanroom oven number 395, 2008.

859

THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY

Add: 23 Business Park Drive Branford, CT 06405 Tel: (203) 315-4000 E-mail: [email protected]

2742

THE IMMUNE RESPONSE CORP.

Web site: www.ipd-discovery.com

Add: 5935 Darwin Court Carlsbad, CA 92008

President/CEO: James Nolan

Tel: (760) 431-7080

R&D expertise: Drug discovery, research and production directed to novel therapeutic intervention for specific disease states.

Fax: (760) 431-8636 E-mail: [email protected] President/CEO: Dennis J. Carlo, Ph.D. Research director: Dennis J. Carlo, Ph.D. R&D expertise: R&D and manufacture/ marketing of products to treat HIV infection, autoimmune diseases — rheumatoid arthritis, multiple sclerosis and psoriasis; gene therapy, drug delivery technology, and cancer therapy — colon, brain and prostate. Joint ventures: Agouron for treatment of HIV. Key license and trade contracts: Trinity Medical Group Co., Ltd. — HIV for Thailand

Technological expertise: COC, HTDS, SMC, SY, DDI Principal products/instrumentation: Novel therapeutic drugs, drug discovery route.

2744

THE NEST GROUP, INC.

Add: 45 Valley Road · Southborough, MA 01772-1323 Tel: (508) 481-6223 Fax: (508) 485-5736

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Web site: www.nestgrp.com

R&D collaboration: U.S. Army Corps, YSI International.

President: Amos Heckendorf, Ph.D.

Key sales market contracts: Sigma Chemical.

R&D expertise: Development and manufacture of chromatographic products for the analysis and scale-up of peptide, protein or polynucleotide isolations.

Technological expertise: E, BA, ET, ERT

E-mail: [email protected]

Principal products/instrumentation: Nitrate test kits.

Key sales market contracts: Bischoff Chromatography, Higgins Analytical, PolyLC, Vydac, and AmiKa Sialomed.

Main products/instrumentation under R&D: Nitrate biosensor, prototype, NIH grant; Enzyme based system for water treatment, early prototype; immobilized enzymes.

Technological expertise: P/S, PC, PI, PIS, PPAT, PS, PS/AP, P/PS, RPP

Subsidiary bodies: Lab: 217 Calumet St, Lake Linden, MI.

Principal products/instrumentation: Vydac™, PolyLC™, Jordi-Gei™, Macherey-Nagel Nucleogen™, Higgins Analytical HAISil™ 100, TARGA™ & CLIPEUS™, and Bischoff Prontosil™ HPLC columns and media. Genomic Solutions™ PAGE mini-gels. AmiKA COZAP Protein Destaining pads; BioDialyser and Dispo-Bio-Dialyser™; and ProTip™ MS MicroSarnple SPE Tips, KronLab BioCart™ and KronLab PRO™ preparative, high pressure, adjustable glass columns; EXCLUSIVE™, Agarose. Main products/instrumentation under R&D: Chromatographic-grade reagents, chromatographic-grade solvent.

2746

DSM PTG

Add: 2810 7th St. Berkeley, CA 94710 Tel: (510) 841-8800 Fax: (510) 841-7800 E-mail: [email protected] Web site: www.dsm.com. President/CEO: Robert S. Ward Research director: Ted Parker R&D expertise: Manufacture of materials for medical devices and polymers products. Technological expertise: TE, DD, SY, BME, POS, PLHDDT

2745

THE NITRATE ELIMINATION CO., INC.

Add: 334 Hecla St. Lake Linden, MI 49945 Tel: (906) 296-1115 E-mail: [email protected] Web site: www.nitrate.com President: Dr. Wilbur H. Campbell Research director: Dr. Wilbur H. Campbell R&D expertise: Research of environmental/ industrial biotech, and immobilized enzyme; related applied products manufacture.

Principal products/instrumentation: Bionate (Polycarbonate-urethanes), BioSpan™ (Segmented Polyurethanes), Pur-siT (SiliconePolyether Urethane), CarboSil™ (Silicone Polycarbonate Urethane), Elastane™ PolyetherUrethane. Main products/instrumentation under R&D: VAD, LAB catheters, vascular grafts, cell substrates R&D, hybrid artificial organs, bioresorbable polymers, semi-permeable membranes. Sealed and granted patents: Surface modifying end groups; semi-permeable membranes.

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THERAMED, INC.

Add: 3441 Golden Gate Way Lafayette, CA Tel: (925) 284-4070

861

Principal products/instrumentation: Contract R&D drug products. Main products/instrumentation under R&D: Drug delivery technology.

Fax: (301) 217-9594 E-mail: [email protected].

2749

THERATECH, INC.

President/CEO: Douglas A. Doerfler Research director: J. Fratanton, M.D.

Add: 1109 Myatt Blvd. Madison, TN 37115

R&D expertise: Research, design, development, production and commercialization of applied technologies that enables human blood cells to be utilized as targeted drug and gene delivery vehicles.

Tel: (800) 788-1705

R&D collaboration: EntreMed, University of Cincinnati.

Fax: (800) 485-2626 E-mail: [email protected] Web site: www.stimsupply.com President/CEO: Dinesh C. Patel, Ph.D. Research director: Charles D. Ebert, Ph.D.

Technological expertise: GN, H, PH, PA, P, Q, TE, T, AF, BA, C/TC, CH/SAD, GT, G, H/CF, HTDS, RD, R, SMC, PG

R&D expertise: R&D and manufacture of innovative controlled release drug delivery systems.

Main products/instrumentation under R&D: Enhanced red blood cells — O2 delivery, preclinical; Platelets for drug delivery, preclinical; White blood cells for gene therapy, preclinical.

R&D collaboration: Astra AB, Eli Lilly, Meiji, Palatin Technologies, INC., Pfizer, Procter & Gamble, SmithKline Beecham, Sankya

Sealed and granted patents: Four issued U.S., numerous pending and non-U.S. counterparts.

Key sales market contracts: Procter & Gamble, SmithKline Beecham, Astra AB, Schwarz Pharma, CEPA, Lavipharm SA, Samyang, Meiji, Sankyo, Univ. Medical Products, Wyeth Ayerst Technological expertise: DD

2748

THERAPEUTIC DISCOVERY CORP.

Add: 1454 Page Mill RoadPalo Alto, CA 94303-0806 Tel: (650) 496-8200 President: Gary L Neil, Ph.D. R&D expertise: Development and manufacture of pharmaceutical products, incorporating drug delivery technology. R&D collaboration: Alza Corporation. Key license and trade contracts: Alza Corporation. Technological expertise: DD

Principal products/instrumentation: Androderm® transdermal testosterone system; Alora® estradiol transdermal system, Nitroglycerin transdermal patch (Europe only), FaceLift™ Anti-Wrinkle Patch. Main products/instrumentation under R&D: Estradiol/Progestin, matrix patch, Phase III/IV; Testosterone, for men, matrix patch, Phase III/ IV; Testosterone, for women, matrix patch, Phase II; Oxybutynin, matrix patch, Phase III; Nicotine lozenge, Phase III; Estradiol/Testosterone, matrix patch, Phase I; Desmopressin, oral transmucosal, Phase II; Lilly Peptide, oral transmucosal, development; Anti-fungal, topical matrix patch, development; PT-14, oral

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transmucosal, development; Calcitonin, oral transmucosal, research; Drug Targeting, oral transmucosal and injection, research. Sealed and granted patents: 50 patents.

2750

THERATECHNOLOGIES, INC.

Molecule TH 9402; irradiation photodynamic device; Modified GLP-A peptides with increased biological potency, 7,067,488, U.S.; other patents are pending.

2751

THEREXSYS, LTD.

Add: 2310 Alfred-Nobel Blvd. Montréal, Québec H4S 2B4 Canada

Add: The Science Park University of Keele Keele, Staffordshire ST5 5SP U.K.

Tel: (514) 336-7800

Tel: (44) 178-271-4181

Fax: (514) 336-7242

Fax: (44) 178-271-4167

E-mail: [email protected]

CEO: Roger K. Craig, Ph.D.

Web site: www.theratech.com

Research director: Andrew Mountain, Ph.D.

President/CEO: Andre de Villers

R&D expertise: R&D of targeted gene therapy, related novel products development and manufacture.

Research director: Dr. Nestor Molfino R&D expertise: R&D and production of biotechnology medicines, focuses on the research and development of healthcare products. Concentration on two therapeutic areas: tissue regeneration through GRF analogues and photodynamic cancer treatment. Key sales market contracts: Vetoquinol SA. (distribution of veterinary diagnostic kits), Hewlett Packard (distribution of Stethos for affiliate Andromed). Key license and trade contracts: Genetix Pharmaceuticals (Vpr/gene transfer research collaboration agreement), BioArtifical Gel Technologies (growth factors). Technological expertise: PIS, C/TC Principal products/instrumentation: Veterinary diagnostic kits, STETHOS™ electronic stethoscope, SEQUS software. Main products/instrumentation under R&D: Tissue generation through Growth HormoneReleasing Factor(GRF) analogues, Phase II; Photodynamic therapy for cancers affecting bone marrow, Phase II/III, clinical validation, medical device in Canada. Sealed and granted patents: ThGRF 1-29 analogue; ThGRF 1-44 analogue; Photosensitive

R&D collaboration: Gryphon Sciences. Key license and trade contracts: Medical Research Council; Cancer Research Campaign; Erasmus University, Rotterdam. Technological expertise: F, PIS, RD, P/S, BA, H/CF, C/TC, DD, GT, D-D Main products/instrumentation under R&D: Products for cancer and vaccines, targeted gene therapy. Sealed and granted patents: LCR technology.

2752

THERICS, INC.

Add: 1800 Triplett Blvd. Akron, Ohio OH 44306 Tel: (330) 475-8600 Fax: (330) 773-7697 E-mail: [email protected] Web site: www.therics.com President/CEO: James Warle Research director: Don Monkhouse, Ph.D. Subsidiary of Tredeqar Corporation.

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R&D expertise: R&D of novel patented fabrication technology for drug delivery systems, tissue healing scaffolds, medical & dental devices, in vitro diagnostics and veterinary products. R&D collaboration: Sciences

Advanced

863

for treatment of colorectal cancer and lung cancer, Phase II~III, 2008.

2754

THERION BIOLOGICS CORP.

Tissue

Key license and trade contracts: Exclusive license from Massachusetts Institute of Technology for all medical applications of 3-dimensional printing.

Add: 76 Rogers St. Cambridge, MA 021421119 Tel: (617) 475-7500 Fax: (617) 475-7501 President/CEO: Dennis Panicali, Ph.D.

Technological expertise: TE, DD

Research director: Gail P. Mazzara, Ph.D.

Principal products/instrumentation: Organ transplants/culture products, vaccines, veterinary products.

R&D expertise: Vaccines as preventive and immunotherapeutic products for AIDS and cancer.

Main products/instrumentation under R&D: Patented fabrication technology for drug delivery systems, tissue healing scaffolds, TBC-3B (Vaccinia virus expressing HIV genes env, gag and pal) for AIDS prevention.

R&D collaboration: NCI, Pasteur Merieux Cormaught, Ludwig Institute for Cancer Research,

2753

THERION BIOLOGICS

Key sales market contracts: Pasteur Merieux Connaught Key license and trade contracts: University of Florida, Harvard University, NIH, Pasteur Merieux Connaught

Add: 76 Rogers St., Cambridge, MA 021421119

Technological expertise: Q, GT, RD, P/S, BA, C/TC

Tel: (617) 475-7500

Main products/instrumentation under R&D: Preventive vaccines, TBC-CEA (vaccinia virus expressing carcinoembryonic antigen) to treat colorectal/lung cancer, Phase II; PROSTVAC recombinant vaccinia virus expressing PSA to treat prostate cancer, Phase II/III;, rV-gp100, rF-gp100 (recombinant fowlpox virus) to treat melanoma, Phase III, rV-MART-l, rF-MART-l, TBC-3B: All Phase II or II/III; rF-PSA, rVB7.1, rF-B7.1, rV-MUC-1, and others, preclinical; PANVAC-VF, Phase III, 2008.

Fax: (617) 475-7501 R&D expertise: Biological products (dxcept diagnostic) development/manufacture. Technological expertise: C/TC, E, F, T, DD Main products/instrumentation under R&D: γ F-gp100(recombinant fowlpox virus)for treatment of melanoma, Phase III; Prostvac recombinant vaccinia virus expressing PSA to treat prostate cancer, Phase II~III; γ F — TYR(recombinant fowlpox virus expressing tyrosinase), γ V-gp100(recombinant vaccinia virus) and γ F — TYR(recombinant vaccinia virus expressing tyrosinase), for treatment of melanoma, Phase II~III; γ V — MUC-1 to treat breast cancer, Phase II; TBC CEA (vaccinia virus expressing carcinoembryonic antigen),

2755

THERMOGEN, INC.

Add: 2225 West Harrison Street Chicago Illinois IL 60612 Tel: (312) 226-6500

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2757

President: David Demirjian

THERMOQUEST/FORMA SCIENTIFIC DIV.

R&D expertise: Development and manufacture of peptides, peptide instrumentation, stable biocatalysts from thermophilic organisms, enzyme engineering, etc.

Add: Millcreek Rd. P.O. Box 649 Marietta, OH 45750

Technological expertise: CC, E, F, P, BC, S, RD, Q, P/S, GA, CB, BI, SY

Fax: (740) 373-6770

Principal products/instrumentation: ThermoCat stable biocatalysts for chemical synthesis, biocatalyst from thermophilic organisms, peptide equipments. Main products/instrumentation under R&D: Recombinant DNA, thermostable enzymes, thermophile promoters. Sealed and granted patents: Recombinant DNA and methods for producing thermostable enzymes. 350,591, U.S.; Thermus promoters for gene expression. 6,294,358, U.S.; Methods for isolation of thermophile promoters. 6,344,327, U.S.

2756

Tel: (740) 373-4763 E-mail: [email protected] President: Randall Andersen Research director: Robert Outright R&D expertise: Development and manufacture of biomedical laboratory equipment/ instrumentation and labowares. Technological expertise: BME, BS Principal products/instrumentation: Laboratory, incubators; ultra-low temp freezers; biosafety cabinets; blood bank equipment; baths/ circulators; glassware washers; cryopreservation equipment; orbital shakers/incubators. Main products/instrumentation under R&D: Biomedical laboratory novel equipment/ instruments/labwares.

THERMOQUEST CORPORATION

Add: 355 River Oaks Pkwy. San Jose, CA 95134 Tel: (408) 965-6800 Fax: (408) 965-6132 President: Ian Jardine, Ph.D.

2758

THERMO SEPARATION PRODUCTS

Add: 355 River Oaks Pkwy. San Jose, CA 945 artigan

R&D expertise: R&D of proteomics, drug discovery and environmental analysis, related products manufacture.

Subsidiary of ThermoQuest

Key sales market contracts: Beckman Coulter, INC. for Le-Ms/Ms System.

Technological expertise: CC, P/S, CH/S, BME

Technological expertise: BI, CH/S, G, R, BME, HC Principal products/instrumentation: Mass spectrometers; HPLC, TurboSequest. Main products/instrumentation under R&D: Proteome System Analyzer, drug discovery route, environmental analysis technologies.

R&D expertise: R&D and manufacture of biomedical analytical instruments. Principal products/instrumentation: SPECTRA PHORESIS® capillary electrophoresis instruments; SPECTRA SYSTEM® Liquid chromatography instruments and systems. Main products/instrumentation under R&D: Biomedical analytical instruments. Subsidiary bodies: Thermo BioAnalysis Ltd., Herts, U.K.

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2759

THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCS, INC.

Add: 505 Coast Blvd. S. Suite 300 La Jolla, CA 92037 Tel: (619) 452-5892 Fax: (619) 452-9279 President/CEO: William T. Comer, Ph.D. Research director: Michael M. Harpold, Ph.D. R&D expertise: Discovery, design and development of novel, effective therapeutic products for diseases and disorders of the nervous system, such as Alzheimer’s disease etc. R&D collaboration: Eli Lilly and Co., CibaGeigy Ltd., and Bristol-Myers Squibb. Technological expertise: CC, E, PA, SMC, Q, T, BI, C/TC, COC, CH/S, D-D, DD, HTDS, RD, R, SY Principal products/instrumentation: Novel effective therapeutic drug products, drug discovery route.

2760

THE SALZMAN CORPORATION

Add: 308 East River Dr. Davenport, IA 52801 Tel: (319) 324-1028 Fax: (319) 324-6221. President/CEO: Gary McDaniel R&D expertise: Development of serum products and animal glands. Technological expertise: C/TC, BA Principal products/instrumentation: Ultrasenim fetal calf serum. Main products/instrumentation under R&D: Supplemental serums.

Tel: (573) 547-8653 President: Rick Mulford R&D expertise: Development, manufacture and supply of of non-sterile animal sera ISO-9002 registered. Technological expertise: C/TC Principal products/instrumentation: Donor herd florse serum, newborn calf serum, porcine serum, bovine calf, formula-fed calf serum. Main products/instrumentation under R&D: Novel non-sterile animal sera.

2762

SIRIS GROUP, LLC.

Add: 96 Horseshoe Ln Perryville, MO 63775

THE TECHNOLOGY PARTNERSHIP PLC

Add: Melboum Science Park Melboum, Hertfordshire SG8 6EE U.K. Tel: (44) 1763-262-626 Fax: (44) 1763-261-582 E-mail: [email protected] Web site: www.ttp.com President: Gerald Avison, Ph.D. R&D expertise: Research of drug engineering, process development, drug delivery and diagnostics, high throughput screening systems and compound libraries. Technological expertise: C/TC, COC, CH/S, DD, F, HTDS, PMC, R, SY, BI, SMC Principal products/instrumentation: Contract research/clinical trial pharmaceuticals, TouchSpray electronic aerosol, key patent, some licenses available; Acumen HTS system for drug discovery; Actif, improved multi-dose powder inhaler. Main products/instrumentation under R&D: High throughput screening system, drug compound library, drug delivery devices, diagnostics.

2763 2761

865

THIRD WAVE TECHNOLOGIES, INC.

Add: 502 S. Rosa Road Madison, WI 53719

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Tel: (608) 273-8933

Tel: (407) 423-8969

Web site: www.twt.com

Fax: (407) 423-7021

President/CEO: Dr. Lance Fors

President: Lynn Matthews

Research director: Dr. Bruce Neri

Research director: Tim Matthews

R&D expertise: R&D and manufacture/ marketing of proprietary functional genomic tools for medical and pharmaceutical research, and the clinical diagnostic market

R&D expertise: Development, production and marketing of chromatographic data analysis software.

Technological expertise: E, Q, CH/S, PG

Principal products/instrumentation: Target, Envision, Target DB.

Principal products/instrumentation: CFLF Research Reagents, Clearase I Enzyme and Reagents Main products/instrumentation under R&D: Invader™ DNA and RNA assays, preclinical (clinical segment, research market-released), functional genomic tools for pharmaceutical research.

2764

THM BIOMEDICAL, INC.

Technological expertise: COC, CH/S, HTDS

Main products/instrumentation under R&D: Chromatographic data analysis software.

2766

TIME LOGIC, INC.

Add: 1914 Palomar Oaks Way Suite 150 Carlsbad CA 92008 Tel: (760) 431-1263 Fax: (760) 431-1351

Add: 325 Lake Ave. South Ste. 608 Duluth, MN 55802

E-mail: [email protected]

Tel: (218) 720-3628

President/CEO: Richard Offerdahl

Fax: (218) 720-3715

Research director: Jim Lindelien

E-mail: [email protected] Research director: John H, Brekke, DDS

R&D expertise: Development and manufacture of high speed computational genomics servers.

R&D expertise: Development of tissue engineering, related applied products manufacture.

Key sales market contracts: Pangea Systems; NetGenics, INC.; GCG; Teijin

Technological expertise: TE, C/TC, DD

Technological expertise: BI, CH/S

Principal products/instrumentation: Biomaterials, Drilac®, Epi-Guide®.

Principal products/instrumentation: DeCypher II Comparative Genomic Server.

Main products/instrumentation under R&D: Bone graft substitute; cartilage repair and regeneration, novel tissue engineering products.

Main products/instrumentation under R&D: High speed computational genomics servers.

President/CEO: Thomas H. Maas

Web site: www.timelogic.com

2767 2765

THRU-PUT SYSTEMS, INC.

Add: 450 E. South Street, Suite 201 Orlando, FL 32801

TISSUE CULTURE BIOLOGICALS

Add: 3020 Old Ranch Parkway, Suite 300F Seal Beach, CA 90740 Tel: (800) 845-1445

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Fax: (866) 923-3279

Tel: (650) 244-4990

E-mail: [email protected]

Fax: (650) 244-4956

Web site: www.tcbio.com

Web site: www.titanpharm.com

President/CEO: Ross Hodges

President/CEO: Louis R. Bucalo, M.D. CFO: Robert E. Farrell (COO: Sunil Bhonsle)

Research director: Lloyd Cranford R&D expertise: Development and manufacture of high quality products at competitive prices. Technological expertise: C/TC Principal products/instrumentation: Animal blood sera. Main products/instrumentation under R&D: High quality cell/tissue culture.

2768

TISSUE INFORMATICS, INC.

Add: 3636 Boulevard of the Allies, Pittsburgh, PA 15213 Tel: (412) 209-7440 Fax: (412) 209-7445 E-mail: [email protected] President: Mary Vel Brady R&D expertise: Development, manufacture and supply of complete solutions to tissue engineering, pharmaceutical, genomics and related industries through tissue services, imaging and analysis, research support, quality assurance and consulting services.

R&D expertise: R&D and manufacture of novel and proprietary products for the improved treatment of cancer and central nervous system disorders. R&D collaboration: Novartis PharmaAG (Zomaril™); Schering AG (Spheramine™) Key sales market contracts: Novaritis Pharma AG (Zomaril™); Schering AG (Spheramine™) Key license and trade contracts: Novaritis Pharma AG (Zomaril™); Schering AG (Spheramine™) Main products/instrumentation under R&D: Zomarit™, Phase III/IV (Schizophrenia); Spheramine™, Phase II/III (Parkinson’s Disease); Ceavac®(anti-idiotype antibody vaccine), Phase III/IV (Duke’s D colorectal cancer); TriAB™ anti-idiotype antibody vaccine, to treat breast cancer, Phase III (metastatic breast cancer); CeaVac and TriAB™, Phase III (non-small cell Lung Cancer); Tri Gem™ anti-idiotype antibody vaccine to treat small-cell lung cancer, melanome, Phase III (Melanoma); Pivanex™, preclinical; MDRx1™ (gene therapy) enables high-dose chemotherapy with reduced side effects, Phase II. Subsidiary bodies: Somerville, N.J.

Technological expertise: BI, C/TC, CH/S Principal products/instrumentation: Contract research/clinical trial products, tissue acquisition services, tissue analysis, management and dissemination of tissue-based information, imaging and analysis.

2770

TL SYSTEMS CORP.

Add: 8700 Wyoming Ave. N. Minneapolis, MN 55445-1836 Tel: (763) 424-4700 Fax: (763) 493-6776

2769

TITAN PHARMACEUTICALS, INC.

Add: 400 Oyster Point Blvd., Suite. 505 South San Francisco, CA 94080-1921

President: Don DeMorett Research director: Alan Peterson R&D expertise: Design, development and manufacture of high speed filling equipment for cleanrooms and barrier isolator technology.

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Technological expertise: BME Principal products/instrumentation: MAFS™ — Mini Aseptic Filling System utilizing barrier isolation technology; complete line of cartoners, thermoformers, capsule fillers, checkweighers, liquid gauges for vials, syringes, I.V. bags for cleanrooms and barrier isolation applications. Main products/instrumentation under R&D: High speed filling equipment for cleanrooms.

Tel: (800) 421-3701 Fax: (800) 483-1993 E-mail: [email protected] Web site: www.tocris.com President: Dr. David Sunter Research director: Dr. Duncan Crawford R&D expertise: Manufacture and marketing of specialty chemicals for biopharmacology and neurochemistry research. Technological expertise: SMC, SY

2771

TM BIOSCIENCE CORPORATION

Add: 439 University Ave. Ste. 900 Toronto, ON M5G 1Y8 Canada Tel: (416) 593-4323 Fax: (416) 593-1066 E-mail: [email protected] Web site: www.tmbioscience.com President/CEO: Gregory C. Hines Research director: Roman Zastawny, Ph.D. R&D expertise: Research of genomic analysis; production of diagnostics (DNA), biochips and antisense therapeutics. Technological expertise: AB, BI, G, HTDS, PG, AS, GA Principal products/instrumentation: DNAbased diagnostic platform; signal amplification; antisense therapeutics; biochip; genomic analysis. Main products/instrumentation under R&D: Nucleic acid hairpin capture moiety. Subsidiary bodies: Wobum, MA. Sealed and granted patents: Nucleic acid hairpin capture moiety, 5593834, 5770365, 5902724, 6027884, 6060248.

Principal products/instrumentation: Specialty chemicals, reagents.

2773

TOKRA MEDIKAL, LTD.

Add: Bagdatcool No. 95/10 Krahopnak Kadukay, Istanbul 81040 Turkey Tel: (90) 216-348-8820 Fax: (90) 216-368-4013 E-mail: [email protected] Web site: www.tokra.com.tr President: Mehmet Lubrul Research director: Alineza Masheghant R&D expertise: Research of genetics and biochemistry; related novel products manufacture. Technological expertise: E, PA, Q, SMC, TE, R, CB, C/TC, GA, H/CF, RD, G Principal products/instrumentation: Biologicals, Human Genome Project, genetic module, organ transplants/culture, vaccines, reagents.

2774

TOMTEC, INC.

Add: 1000 Sherman Ave. Hamden, CT 06514 Tel: (203) 281-6790

2772

TOCRIS COOKSON, INC.

Add: 16144 Westwoods Business Park, Ellisville, Missouri MO 63021

Fax: (203) 248-5724 E-mail: [email protected] Web site: www.tomtec.com

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President: Thomas W. Astle R&D expertise: R&D and production of automated equipment for high throughput screening, 96 well liquid handling, pipetting and harvesting robotics. Key sales market contracts: Sales and distribution of Harvester 96 and 96 well pipetting stations, the Quadra 96, are direct, worldwide sales, in the U.S. through Wallac, Inc., worldwide sales through distributors. Technological expertise: SMC, COC, HTDS, R, BME Principal products/instrumentation: Quadra 9600: Automated High Throughput Screening System; Quadra 96: 96 well pipetting stations; Harvester 96: 96 well cell harvesters; Robot accessible: incubators, hotels, plate sealers, and plate washers; Registered trademarks: TOMTEC, HARVESTER 96. Main products/instrumentation under R&D: Automated equipment for high throughput screening.

2775

TONEN CORP.

Add: 1-1-39 Hiroo, Shibuya-ku Tokyo 150 Japan Tel: (813) 5778-5090 Fax: (813) 5778-5198 President: Tamehiko Tamahori Research director: Tohru Yasumoto R&D expertise: Development and supply of proprietary materials to diagnostic drug production.

869

Principal products/instrumentation: AntiproGRP antibodies; antigens and antibodies of HCV; ProGRP™ antibodies. Main products/instrumentation under R&D: Proprietary materials produced diagnostic drugs.

2776

TOPLAB GMBH

Add: Fraunhoferstr. 18a D-82152 Martinsried Germany Tel: (49) 898-565-1283 Fax: (49) 898-565-1286 E-mail: [email protected] Web site: www.toplab.de President: Dr. Elfreide Miller Research director: Dr. Elfreide Miller R&D expertise: Proteomics and genomics research, related applied products development. Technological expertise: Q, G, PG, S Principal products/instrumentation: Biomaterials, contract manufacturing products, clinical trial products. Main products/instrumentation under R&D: Genomic marker, proteomic sequencing.

2777

TORONTO RESEARCH CHEMICALS, INC.

Add: 2 Brisbane Rd. North York, Ontario M3J 2J8 Canada Tel: (416) 665-9696 Fax: (416) 665-4439

R&D collaboration: International Reagents Corp.

E-mail: [email protected]

Key sales market contracts: International Reagents Corp.

President: Dr. David S. Dime

Technological expertise: F, Q, SY, C/TC, RD, P/S, BA, GA, H/CF, PMC, CH/S

R&D expertise: Biomedical research, development of bioprocess engineering; drug discovery

Web site: www.trc-canada.com Research director: Dr. David S. Dime

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research, biochemical medicines manufacture; Organic chemical synthesis, isotopic labeling, specialty chemicals production. Technological expertise: CC, CB, SMC, SY Principal products/instrumentation: 5-FOA, Sialic Acid, specialty chemicals for biomedical research and custom synthesis products, complex organics, including: heterocyclic compounds, carbohydrates, aromatic, organosulfur compounds, lipids. Main products/instrumentation under R&D: Research chemicals, including: fluorescent probes, sulfhydryl active compounds, crosslinkers, carbohydrates, spin labels, amino-acid derivatives. Drug canditates, including: glycosidose inhibitors, calcium and NA ion channel blockers. These products are used to treat cardiovascular disease and cancer.

2778

TORTUS USA CORP.

Add: P.O. Box 1956 Old Chelsea Station New York, NY 10113 Tel: (212) 929-1626 Fax: (212) 929-0927 E-mail: [email protected] Web site: www.tortus.com President/CEO: J. Kroin R&D expertise: Plant rooting research/ development and products manufacture. Joint ventures: Rhizopon BV, Phytotronics Key sales market contracts: Phytotronics Key license and trade contracts: Rhizopon BV

2779

TOSOH BIOSEP, LLC.

Add: 156 Keystone Dr. Montgomeryville, PA 18936-9637 Tel: (215) 283-5000 Fax: (215) 283-5035 President: Hiroyum Uchida Subsidiary: Tosoh Corporation R&D expertise: R&D and manufacture of bioseparation products to pharmaceutical and biotechnology industries. R&D collaboration: Tosoh Corp. Key sales market contracts: Rohm and Haas Co. Technological expertise: P/S, BA, HC Principal products/instrumentation: TSKGEL HPLC columns and bulk media, Toyopearl and Amberchrom preparative resins. Nonporous Ion Exchange Columns: TSKGEL STAT is a series of ion-exchange columns in a line of high-performance liquid chromatography (HPLC) columns. 2009; Nonporous Ion Exchange Columns: TSK-GEL STAT is a series of ion-exchange columns in a line of high-performance liquid chromatography (HPLC) columns. The columns allow fast equilibration and analysis of complex biopolymer samples, 2009. Main products/instrumentation under R&D: Bioseparation products to biotechnology industries. Subsidiary bodies: Zettachring 6, D-70567 Stuttgart, Germany, Tel: (49) 711-13257-0, Fax: (49) 711-13257-89

Technological expertise: C/TC, T, E, TE Principal products/instrumentation: Plant rooting Hormones, Rhizopan AA, IBA Water Soluble Salts. Main products/instrumentation under R&D: Plant rooting lectin, plant rooting nucleic acid.

2780

TOTAM BIOLOGICALS, LTD.

Add: Beckett House 14 Billing Rd. Northampton NN1 SAW U.K. Tel: (44) 160-462-1051 Fax: (44) 160-423-0086

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E-mail: [email protected] President: Ronald Van Dijk Subsidiary of TEBU, France. R&D expertise: Development and manufacture of life science reagents for researchers. Key sales market contracts: U.K. distributor of in vitro technologies, cascade biologies.

871

B, C; Toxic Shock Syndrome Toxin — 1; Shiga Toxins, antibodies to all toxins. Main products/instrumentation under R&D: Recombinant Staph and Strep toxin, other biochemicals and biotechnology medicines.

2782

TRACE AMERICA, INC.

Technological expertise: RD, C/TC Principal products/instrumentation: Contract research/clinical trial products, in vitro toxicology testing method, organ transplants/ culture products, vaccines, complex for normal human cells plus media and supplements, hepatocytes, microsomes and S9.

Add: 845 Avenue G Arlington, TX 760117709 Tel: (800) 872-2313 Fax: (305) 477-0256 E-mail: [email protected] President: David Johnston Subsidiary of Trace Scientific Limited

2781

TOXIN TECHNOLOGY, INC.

R&D expertise: R&D and manufacture of diagnostics, biologicals, veterinary therapeutics.

Add: 7165 Curtiss Ave. Sarasota, FL 342318012

Joint ventures: Longmarch Trace Shanghai China Erbos Croatia.

Tel: (941) 925-2032

Technological expertise: E, P/S, C/TC, P/PS, RPP, PPAT, PC

Fax: (941) 925-2130 E-mail: [email protected] Web site: www.toxintechnology.com President/CEO: Raoul F. Reiser, Ph.D. Research director: Raoul F. Reiser, Ph.D. R&D expertise: Development and production of biochemicals and biotechnology medicines. Key sales market contracts: Alexis Corporation, Switzerland; Cosmo Bio, Japan. Key license and trade contracts: University of Wisconsin; CDC, Atlanta; University of Auckland, NZ; Henry Jackson Foundation, Rockville, MD. Technological expertise: F, P/S, C/TC, H/CF, COC Principal products/instrumentation: Contract manufacturing diagnostics, in vitro toxicology testing methods, Staphylococcal Enterotoxins A-E; Streptococcal Exotoxins A,

Principal products/instrumentation: Trace diagnostics reagents, complex for trace diagnostics bioscience- proteins + mitogens, veterinary biologic. Main products/instrumentation under R&D: Stabilizing reagents for veterinary use. Sealed and granted patents: 5 patents held in reagent stabilization and veterinary applications of IGS.

2783

TRACE SCIENTIFIC, LTD.

Add: 189-199 Browns Road Woble Park Victoria 3174 Australia Tel: (613) 9543-1255 Fax: (613) 9543-6719 E-mail: [email protected] CEO: Tony Bigum

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Research director: Lance Smith Subsidiary of Thermo Bioanalysis.

for universal primer fluorescent capillary electrophoresis, 2007.

R&D expertise: Manufacture of cell culture products, development of proteins for cell and tissue culture, serums, veterinary products.

Main products/instrumentation under R&D: Integrated solutions for separation and analysis of biotechnology products.

Technological expertise: F, TE, AF, BA, CB, C/TC, P.S, RPP, P/PS, PPAT, PC

Sealed and granted patents: Methods and compositions for mutation analysis of polynucleotides by liquid chromatography, 7,135,289, U.S.; Liquid chromatographic separation of polynucleotides. 7,138,518, U.S.; Non-polar media for polynucleotide separation. 6,524,480, U.S. Method and system for RNA analysis by matched ion polynucleotide chromatography. 6,576,133, U.S.; Method for high resolution liquid chromatographic separation of doublestranded DNA. 6, 342, 161, U.S.; System and method for performing polynucleotide separations using liquid chromatography. 6,579,459, U.S.; Method and system for the preparation of cDNA. 6,521,411, U.S.; other patents are pending.

Principal products/instrumentation: Contract manufacturing products, Multicel, Multiser Biocol, Multipro, Fetal Bovine Serum (FBS), Engineered Serum products, Serum Free Media (SFM), Corneal Organ Culture Media, b Transferrin, bBSA, bFetuin, blmmunoglobulin, bAprotinin, 2008. Main products/instrumentation under R&D: Growth factors, purified bovine byproducts, colostrum substitutes, immunoglobulins, proteins for cell and tissue culture. Subsidiary bodies: New Zealand Protein Plant Sealed and granted patents: Colostrum Supplement for neonates.

2785 2784

TRANSIA-DIFFCHAMB S.A.

TRANSGENOMIC, INC.

Add: 12325 Emmet St. Omaha, NE 68164

Add: 8 rue Saint Jean de Dieu Case Postale No. 8 Lyon Cedex 07 69305 France

Tel: (402) 452-5400

Tel: (33) 72-730-381

Fax: (402) 452-5401

Fax: (33) 72-734-334

E-mail: [email protected]

President: Lundin Jan.Olof

Web site: www.transgenomic.com

Research director: Marie Laure Sorin

CEO: Collin D’Silva

R&D expertise: Development and manufacture of detection kits for agro-food products.

Research director: Douglas Gjerde, Ph.D. R&D expertise: Development and manufacture of integrated solutions for the separation and analysis of DNA/RNA, proteins, peptides, carbohydrates, and amino acids in the areas of mutation detection, genotyping and functional genomics.

Key sales market contracts: European distribution of products Technological expertise: PA, P/S, C/TC, H/CF

Technological expertise: RD, BI, CB, CH/S, P/S

Principal products/instrumentation: Detection kits for listeria, salmonella, staphylococcal enterotoxins and mycotoxines.

Principal products/instrumentation: High throughput Surveyor Mutation Detection Kit

Main products/instrumentation under R&D: Novel detection kits for agro-food products.

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TRANSKARYOTIC THERAPIES, INC.

873

Tel: (619) 410-6500 Fax: (619) 410-6501 E-mail: [email protected]

Add: 700 Main Street Cambridge, MA 02139 Tel: (617) 349-0200 Fax: (617) 491-7903 E-mail: [email protected] Web site: www.tktx.com President/CEO: Richard F Selden, M.D., Ph.D. Research director: Douglas Treco, Ph.D. R&D expertise: R&D and manufacture of biopharmaceutical focused on the production replacement and delivery of proteins for a wide range of human diseases. R&D collaboration: Aventis Pharma, Sumitomo Pharmaceuticals, Genetics Institute. Technological expertise: DD, GT, G, RPP, P/PS, PPAT, PC Main products/instrumentation under R&D: Dynepotm (GA-EPO™, gene-activated™ erythropoietin) for anemia, Phase III/IV, BLA/MAA submitted; Replagal™ for fabry disease, BLA/MAA submitted; Factor VIII gene therapy for hemophilia A, Phase II. Sealed and granted patents: Recently issued: 6,048,524; 6,048,724; 6,048,729; 6,063,630; 5,994,127; 6,018,097; 5, 968,502; 5,733,761; 5,641,670 (~2001); Chemiric proteins for use in transport of a selected substance into cells. 6,858,578, U.S.; Protein Production and Delivery. 6,270,989, U.S. In vivo production and delivery of erythropoietin or insulinotropin for gene therapy. 6,846,676, U.S.; Methods of improving homologous recombination. 6,569,681, U.S.; Optimized messenger RNA. 6,924,365, U.S.; Chimeric proteins for use in transport of a selected substance into cells. 6,262,026, U.S.; other patents are pending.

2787

TREGA BIOSCIENCES

Add: 9880 Campus Pt. Drive San Diego, CA 92121

Web site: www.houghten.com President/CEO: Michael Grey Research director: Michael Green, Ph.D. R&D expertise: Research of combinatorial chemistry/molecular diversity, and applied novel products development. R&D collaboration: Procter & Gamble, Novo Nordisk, Immunex RioboGene, Dura Pharmaceuticals, Cadus, Osiris, Bristol-Myers Squibb. Technological expertise: BI, COC, P/S, R, SMC, SY Main products/instrumentation under R&D: HP 228, Phase III; Type II Diabetes & Obesity, Phase I/II.

2788

TREVIGEN

Add: 8405 Helgerman Court Gaithersburg, MD 20877 Tel: (301) 216-2800 E-mail: [email protected] Web site: www.trevigen.com President/CEO: Michael T. Elliott R&D expertise: Research and manufacture of diagnostic products: DNA damage, DNA repair, apoptosis. Technological expertise: E, PA, GA, HTDS, H/CF Principal products/instrumentation: Reagents and kits for the characterization of DNA mutations, DNA damage and apoptosis. Main products/instrumentation under R&D: DNA damage detection assays, SNP detection methods, detection and mapping of point mutations. Sealed and granted patents: Two U.S. patents on SNP detection methods; Detection and

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mapping of point mutations using partial digestion, 6,548,247, U.S.

Key license and trade contracts: Molecular Probes Public Health Research Institute Technological expertise: AF, BI, P/S, CB, SMC, SY

2789

TRIANGLE PHARMACEUTICALS, INC.

Add: 4 University Place, 4611 University Drive, Durham, North Carolina, NC 27707 Tel: (919) 493-5980 Fax: (919) 493-5925 President: M. Nixon Ellis, Ph.D. Research director: Phi Furman, Ph.D. R&D expertise: R&D of novel pharmaceutical, focus on development of new drug candidates primarily in the antiviral area. Key license and trade contracts: Mitsubishi Chemical Corp.

Principal products/instrumentation: Contract manufacturing products, contract research/clinical trial products, modified oligonucleotides, modified nucleoside triphosphates, radiolabeled oligos. Main products/instrumentation under R&D: Alpha-galactosidase. Sealed and granted patents: Treatment of alpha-galactosidase a deficiency. 6,458,574, U.S. Pre-activated carbonyl linkers for the modification of oligonucleotides. 6,320,041, U.S.

2791

Technological expertise: SMC Main products/instrumentation under R&D: MKC-442 — HIV, Phase Ib/IIa; FTC — HIV and HBV, preclinical; DAPD — HTV and HBV, preclinical; CS-92 — HIV, preclinical; Acyclovir Monophosphate-Resistant Herpes and Herpes Labialis, preclinical; Alanosine — Brain, Lung and other cancers, preclinical; 2CdAP — Psoriasis, preclinical.

2790

TRILINK BIOTECHNOLOGIES, INC.

Add: 9955 Mesa Rim Road San Diego, CA 92121 Tel: (858) 546-0004 Fax: (858) 546-0020

TRILLIUM NEUROSCFENCE, INC.

Add: 4908 Wisconsin Ave., N.W., Ste. 210 Washington, DC 20015 Fax: (301) 498-3961 R&D expertise: R&D and production of drug development in neurology, psychiatry and drug abuse. Key license and trade contracts: National Institutes of Health. Technological expertise: COC, D-D, P/S, SMC Main products/instrumentation under R&D: Innovative drug products to treat neurological disorders, including stroke, epilepsy, head trauma, spinal cord injuries, drug abuse, cough, Parkinson’s disease, and chronic pain, neuropeptide, neuroregulator.

Web site: www.trilinkbiotech.com President/CEO: Richard Hogrefe, Ph.D. Research director: Richard Hogrefe, Ph.D. R&D expertise: Development of modified oligos/nucleotides, novel product manufacture.

2792

TRIMERIS, INC.

Add: 2530 Meridian Parkway, 2nd Floor, Durham, NC 27713

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Tel: (919) 806-4682 Fax: (919) 806-4770 Web site: www.trimeris.com CEO: Richard A. Franco, R.Ph. Research director: M. Ross Johnson, Ph.D. R&D expertise: R&D and production of Antivirals, Antiinfectives. Technological expertise: Q, COC, CH/S, DD, GA, HTDS, PIS, P/S, R Principal products/instrumentation: Biopharmaceuticals, vaccines Main products/instrumentation under R&D: HIV/AIDS, Phase II; RSV, preclinical; Human Parainfluenza-3, preclinical; HCV, preclinical; HBV, preclinical; Epstein-Barr Virus, preclinical; Influenza, preclinical; Marburg Virus, preclinical; CD-8 HIV/AIDS, preclinical. Sealed and granted patents: Composition of matter for T-20 and its homologs.

2793

TRIPOS, INC.

Add: 1699 South Hartley Road. St. Louis, MO 63144-2319 Tel: (314) 647-1099 Fax: (314) 647-9241 Web site: www.tripos.com President/CEO: Dr. John McAlister R&D expertise: R&D and manufacture of life sciences, biotechnology medicines and software. Key sales market contracts: Cyprotex, Lion Bioscience. Technological expertise: BTD, D-D, BI, P/S, COC, SMC, SY, CH/S Principal products/instrumentation: Modeling software, 2008; Alchemy2008; Operating system: SIBYL: UNIX; ChemEnlighten: UNIX, Windows; SYBYL®, integrated molecular modeling environment; UNITY®, database query and analysis system.

875

Main products/instrumentation under R&D: Comparative molecular field analysis. Subsidiary bodies: Tripos Receptor Research, U.K. Sealed and granted patents: CoMFA® (Comparative Molecular Field Analysis).

2794

TRITECH RESEARCH, INC.

Add: 2961 Veteran Avenue, Los Angeles, CA 90064 Tel: (310) 446-4460 Fax: (310) 475-1533 E-mail: [email protected] Web site: www.tritechresearch.com President/CEO: Dr. Andrew Papp Research director: Dr. Andrew Papp R&D expertise: Development, design, manufacture and marketing of less expensive, more convenient equipment for molecular genetic research. Technological expertise: C/TC, CH/S, RD, R Principal products/instrumentation: Contract manufacturing products, Cloning Gun™ cordless, rechargeable hand-held electroporation system, Pipectrode™ pipeting electroporation chambers, microINJECTOR™ microinjection system, DigiTherm™ heating & cooling air incubators, PourBoy II™ media dispenser, GelStopper™ Electrophoresis controller, microscopes, petri dishes. Main products/instrumentation under R&D: Convenient equipment for mole. Sealed and granted patents: Portable electroporation. 5,422,272; electrophoresis control: 5,120,419.

2795

TSENG HSIANG LIFE SCIENCE, LTD.

Add: No. 99-15, Sec. 2 Nan-Kang Rd. Taipei 115 Taiwan

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Tel: (886) 2-2785-1156 Fax: (886) 2-2788-5896 E-mail: [email protected] President: Billy Y-H Chen R&D expertise: Life science research; biotechnology products development and manufacture. Joint ventures: Life Technologies, Inc., U.S.A. Technological expertise: E, F, Q, TE, T, BA, CB, CH/S, D-D, GT, HTDS, PMC, P/S, RD, R Principal products/instrumentation: Tissue and cell culture reagents (LTI U.S.A.), BEIA reader, washer, FLAL1A, Dynex Technologies, tissue and cell culture plastic, Polyclonal Ab/Monclonal Ab. Main products/instrumentation under R&D: Biotechwares, biotech drug.

2796

TSI CORP.

Add: 25 Birch St. Milford, MA 01757-3574 Tel: (508) 478-0877 Fax: (508) 478-1277 President/CEO: Robert Baldridge Research director: Peter Glick R&D expertise: Preclinical and clinical testing research, manufacture of novel developing products. R&D collaboration: NIH, Tufts University School of Veterinary Medicine, University of Massachussetts (Amherst), Exemplar Corp. Key sales market contracts: Sekisui Key license and trade contracts: Licensing agreements: Biogen. Technological expertise: T, RD, P/S, H/CF, C/TC Principal products/instrumentation: Preclinical and clinical testing new drugs, GMP manufacturing support services.

Subsidiary bodies: TSI Argus Research and Center for Photobiology, 905 Sheehy Dr., Bldg. A, Horsham, PA 19044; TSI Mason Laboratories, 57 Union St., Worcester, MA 01608; TSI Redfield Laboratories, 100 E. Boone St, Redfield, AR 72132; TSI Washington Laboratories, 6634- Electronic Dr., Springfield, VA 22151; TSI Washington Laboratories, 5516 Nicholson La., Kensington, MD 20895; TSI Center for Diagnostic Products, 25 Birch St., Milford, MA 01757.

2797

TS SCIENTIFIC

Add: P.O. Box 198 Perkasie, PA 18944 Tel: (215) 257-4756 Fax: (215) 257-6046 President: Dermot O. Dinan R&D expertise: Manufacture, Marketing and technical/applications support for cryopreservation and cryogenic storage. Key sales market contracts: Planer Biomed, Statebourne Cryogenics, I/O Scientific. Technological expertise: T, BA, C/TC, BME Principal products/instrumentation: Planer Kryo 10 controlled rate freezing system; State bourne Cryogenics liquid nitrogen tanks, I/O Scientific Mono-LN and lab alarms.

2798

TSI/AMHERST

Add: 7 Pomeroy Lane Amherst, MA 01002 Tel: (413) 253-6966 Fax: (413) 253-6960 E-mail: [email protected] President: James Doubles R&D expertise: Development and production of instruments for health and safety. Technological expertise: CH/S, BS, D-D, GT, HTDS, SMC

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Principal products/instrumentation: Contract R&D instrumentation, cryogenic equipment. Main products/instrumentation under R&D: Cryogenic refrigerator, instruments for health and safety.

2799

TULARIK, INC.

Add: 2 Corporate Dr. S. San Francisco, CA 94080-7049

877

R&D expertise: Research and manufacture of fluorometers and luminometers for the biotechnology & environmental industries. Technological expertise: GA, PMC, BME Principal products/instrumentation: 10-AU Field Fluorometer, TD-700 Lab Fluorometer, TD-20/20 Luminometer. Main products/instrumentation under R&D: Luminometer for biotechnology industries.

Tel: (415) 615-4200 Fax: (415) 615-4222 President/CEO: James M. Gower Research director: David V. Goeddel, Ph.D.

2801

TYLER RESEARCH CORP.

Add: 10328 — 73 Avenue Edmonton, Alberta T6E 6N5 Canada

R&D expertise: Development and production of biotechnology firm targeting gene separation as means of developing human therapeutics.

Tel: (780) 448-1249

R&D collaboration: Yamanouchi Pharma Co, Ltd.; Merck & Co., Inc.; Sumitomo; Taisho.

Web site: www.tylerresearch.com

Technological expertise: Q, RD, P/S, GA, C/TC, SY, D-D, R

Research director: Jonathan M. Tyler, Ph.D.

Principal products/instrumentation: Human therapeutics of biotech firm targeting gene. Main products/instrumentation under R&D: Polypeptides, targeting gene separation technology. Sealed and granted patents: IRAK3 polypeptides and methods. 6,262,228, U.S.

2800

TURNER DESIGNS

Add: 845 W. Maude Ave. Sunnyvale, CA 94085 Tel: (408) 749-0994 Fax: (408) 749-0998 E-mail: [email protected] Web site: www.turnerdesigns.com President: Mike Mokelke

Fax: (780) 433-0479 E-mail: [email protected] President/CEO: Jonathan M. Tyler, Ph.D. R&D expertise: R&D and production of biomedical equipment/instrumentation and biotech ware, reagents for laboratory biotechnology medicine research. Key sales market contracts: PDI Bioscience, Tabs Trading, Sirex, Keypoint International. Technological expertise: Q, C/TC, GA, PIS, P/S, RD, R, SY, BME Principal products/instrumentation: Contract manufacturing products, Solid-state fluorimeter (SSF-600), hybridization incubator (HI-16000), thermal reactor (TR-96), radiation shielding, vacuum transfer, horizontal and vertical electrophoresis, electrophoresis transfer, preparative gel electrophoresis; multi-well peptide synthesizer. Main products/instrumentation under R&D: Biotech ware, reagents for laboratory biotechnology medicine research.

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TZUF LABORATORIES, LTD.

Add: South Industrial Zone P.O. Box 408 Kiryat Shmona 10200 Israel Tel: (972) 6-959-311 Fax: (972)-6-959-313

ANF and custom synthesis; euprolide, IHRH analogs, desmopressin, calcionin, somatostatin, custom synthesis. Main products/instrumentation under R&D: Other biotechnology drug for therapeutic diseases.

President: Dalit Daily R&D expertise: Development and production of natural products based on express honey for alternative medicine. Antibiotic honey for inflammation of the respiratory tract, wounds, ulcers and inflamemation of the female genitals. Stimulating honey for production and regeneration of blood cells. Honey for general invigoration. Technological expertise: CS, BS, COC, COS Principal products/instrumentation: pharmaceuticals/biopharmaceuticals for prevention/ treatment diseases. Main products/instrumentation under R&D: Natural products, stimulating honey for regeneration of blood cells.

2803

UCB-BIOPRODUCTS, INC.

Add: 840 Memorial Drive Cambridge, MA 02139

2804

U.K. NATIONAL COLLECTION OF PATHOGENIC FUNGI

Add: Mycology Reference Laboratory Public Health Lab Bristol BS2 8BL U.K. Tel: (44) 117-929-1326 Fax: (44) 117-922-6611 Research director: Dr. D.W. Warnock Subsidiary of PHLS (U.K. Government). R&D expertise: Development, maintenance and sale of live culture of human and veterinary fungal pathogens. Technological expertise: AF Principal products/instrumentation: Fungicide, fungistat, fungicidin, fungimycin, contract R&D products. Main products/instrumentation under R&D: Live culture of human and veterinary fungal pathogens.

Tel: (617) 547-0033 Fax: (617) 547-8481 E-mail: [email protected] President: A. Scarso Research director: Y. Qin R&D expertise: R&D and production of biotechnology drug products for therapeutic diseases.

2805

ULTRA-LUM, INC.

Add: 6421 East Alondra Blvd. Paramount, CA 90723-3759 Tel: (562) 529-5959 Fax: (562) 529-5950 President/CEO: Al Kovalsky

Technological expertise: SMC, SY, PIS

Research director: Max Miller

Principal products/instrumentation: Somatostatin calcitonin PTH, LHRH, TRH, vasopressin, oxytocin, glucagons MSH and fragments, bradykinin and analogs, MSM,

R&D expertise: R&D of ultraviolet biotechnology products, gel documentation, imaging/ analysis systems. Technological expertise: Q, RD, GA, P/S

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Principal products/instrumentation: Contract manufacturing products, contract research/clinical trial products; The Ultra Imager 5000™, Big Gel Imager 4500™, Ultra-Glo™, UV-to-Visible Light Converter, Electronic UV Transilluminators, 6000 Series: The Ultra Imager 6000™, Slide-to-side imager 6220™, Big Gel Imager 6240™; ReguLite™ constant-intensity electronic transilluminator; infinite-variable intensity electronic transilluminator.

E-mail: [email protected]

Main products/instrumentation under R&D: Ultraviolet biotechnology products.

Key sales market contracts: Forcaltonin with Strakan (U.K.), Tzamai (Israel).

Sealed and granted patents: Electronic Ballasts for crosslinkers and transilluminators.

Key license and trade contracts: Oral calcitonin development with Warner-Lambert Co.

2806

ULTRA-VIOLET PRODUCTS, LTD.

Add: Unit 1, Trinity Hall Farm Estates, Nuffield Road, Cambridge, England CB4 1TG U.K. Tel: (44) 122-342-0022 Fax: (44) 122-342-0561 E-mail: [email protected] Web site: www.uvp.com Subsidiary of UVP, Inc. R&D expertise: Research of instrumental analysis technology, and related products development and manufacture. Technological expertise: CH/S, BME Principal products/instrumentation: Gel documentation system, associated software for gel analysis; ultraviolet transilluminators, light sources and viewing cabinets.

2807

UNIGENE LABORATORIES, INC.

Web site: www.unigene.com President/CEO: Warren P. Levy Research director: Ronald S. Levy, V.P. R&D expertise: Production of bulk calcitonin, development of oral formulation of calcitonin, manufacturing and delivery of other peptides. Joint ventures: Production of calcitonin for formulation into injectable and nasal products in China-Qingdao Pharmaceutical.

Technological expertise: F, Q, E, D-D, DD, RD, P/S, GA, H/CF, C/TC, PMC, CH/S, SY Principal products/instrumentation: Forcaltonin. Main products/instrumentation under R&D: Delivery technology of peptides. Injectable Calcitonin, completed Phase III; Oral Calcitonin, Phase II. Subsidiary bodies: GMP manufacturing facility in Boonton, NJ. Sealed and granted patents: Amidation process and use in producing amidated peptides, oral delivery of calcitonin; Oral delivery of peptides using enzyme-cleavable membrane translocators, 6,673,574, U.S.; Bacterial houst cell for the direct expression of peptides. 20080057566, U.S. method for fostering bone formation and preservation, 20080057051, U.S.

2808

UNION SCIENTIFIC CORP.

Add: 9633 Liberty Rd. Randallstown, MD 21133 Tel: (410) 496-0200

Add: 110 Little Falls Rd, Fairfield, NJ 07004

Fax: (410) 521-4590

Tel: (973) 882-0860

Web site: www.unionscientific.com

Fax: (973) 227-6088

President: Mitchell Friedman

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Research director: Ben Friedman

Tel: (61) 7-3365-4037

R&D expertise: Contract R&D and manufacture of engineering and design item for biomedical and biochemical sciences.

Fax: (61) 7-3365-4433

Technological expertise: BME Principal products/instrumentation: Electromagnetic Plate Shakers, Microplate Seal Applicators, Vertical Tube Shakers, Lab Automation Equipment. Main products/instrumentation under R&D: Oligo and reagent array printers, flow cytometry apparatus. Sealed and granted patents: Flow cytometry apparatus, electromagnetic shakers.

2809

UNIPATH, LTD.

Add: Wade Rd. Basingstoke RG24 8PW U.K. Tel: (44) 125-684-1144 Fax: (44) 125-646-3388

E-mail: [email protected] Web site: www.uniquest.com.au CEO: Dr. David Evans R&D expertise: R&D and production of novel drug; technology transfer of biotechnology medicines, intellectual property, commercialization, start-up companies. R&D collaboration: CSL Ltd, Glaxo Wellcome. Key license and trade contracts: CSL Ltd. Technological expertise: E, F, Q, TE, T, RD, SMC, SY, P/S, AB, BA, CB, C/TC, COC, DD, D-D, GA, H/CF, PIS Main products/instrumentation under R&D: HPV vaccines, biologicals, biomaterials, bioremediation, contract research/clinical trials products, in vitro toxicology testing method, organ transplants/culture products, antibodies, reagents, peptides and other biotechnology medicines.

CEO: Michael Smith Research director: Patrick Roberts Subsidiary of Unilever.

2811

UNISYN TECHNOLOGIES, INC.

R&D expertise: R&D of bioprocess engineering, microbiology, immunoassays, hydrolosates and peptones.

Add: 25 South St., Ste. G Hopkfnton, MA 01748-2203

Technological expertise: Production of media for fermentation

Fax: (508) 435-8111

Tel: (508) 435-2000

Principal products/instrumentation: Oxiod brand for microbiology, bioferm-hydrolosates and peptones for fermentation, fermentation media from lab to production scale.

Web site: www.unisyntech.com

Main products/instrumentation under R&D: Bioprocess technology, engineering bacteria, immunoassays technology.

R&D expertise: Bioprocess engineering research; Contract manufacturing services for recombinant proteins and monoclonal antibodies for pharmaceuticals research, diagnostic test systems and hollow fiber cell culture.

2810

UNIQUEST PTY, LTD.

Add: Cumbrae Stewart Bldg., Research Rd. University of Queensland Brisbane, Queensland 4072 Australia

President: Peter G. Savas Research director: Alberto Correia (VP and COO)

Technological expertise: H/CF, PMG, LP, BA, C/TC, CH/S Principal products/instrumentation: Contract manufacturing pharmaceuticals, Cell

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Pharm® 2500, Cell Pharm® 2000, Cell Pharm® 3000, Cell Pharm® 1500. Main products/instrumentation under R&D: Cell Pharm® 3500, hollow fiber cell culture, recombinant proteins and monoclonal antibodies for pharmaceutical research. Subsidiary bodies: Contract services: UNISYN, 377 Plantation St., Biotech Bldg. 4, Worcester, MA 01605; Manufacturing Facility: UNISYN, 10954 Via Frontera, San Diego, CA 92127.

2812

UNITECTRA, INC.

Add: Clarastrasse 13 Basel CH-4058 Switzerland Tel: (41) 61-690-9329 Fax: (41) 61-690-9315 CEO: Herbert Reutimann, Ph.D. R&D expertise: Novel drug research, technology transfer in life sciences (biotechnology, healthcare, pharmaceuticals, medical devices).

881

Research director: Alan Walfield, Ph.D. R&D expertise: Research, design, development and manufacture of infectious disease diagnostics, vaccines, etc. Key sales market contracts: Organon Teknika N.V, Kyokuto Pharmaceutical Industrial Co., Ltd., Baxter Healthcare International, Bio-Rad Laboratories, Merial, Inc. Key license and trade contracts: Merial, Inc. Technological expertise: RD, P/S, BA, GA, H/CF, C/TC, SY, DD, D-D Principal products/instrumentation: HIV, HCV, HTLV, FMDV therapeutics. Main products/instrumentation under R&D: HTV vaccine, preclinical testing; HCV vaccine, preclinical testing; prostate cancer therapy; Chlamydia vaccine, preclinical testing. Sealed and granted patents: Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens, 6,713,301, U.S.

Technological expertise: BC, AB, COC, F, GA Joint ventures: Swiss Priority Program Biotechnology; University of Zurich; University of Bern; other research institutions. Principal products/instrumentation: Contract R&D drug products. Main products/instrumentation under R&D: Drug technology transfer, human healthcare drug, medical devices. Subsidiary bodies: University of Zurich; University of Bern.

2814

UNIVERA PHARMACEUTICALS

Add: 100 Technology Dr., Ste. 160 Broomfield, CO 80021 Tel: (303) 438-8666 Fax: (303) 438-9483 E-mail: [email protected] President: Bill Lee Research director: Dr. Steve Omdorff, Ph.D. Subsidiary of Namyang.

2813

UNITED BIOMEDICAL, INC.

Add: 25 Davids Dr. Hauppauge, NY 11788 Tel: (631) 273-2828 Fax: (631) 273-1717 Web site: www.unitedbiomedical.com President/CEO; Chang Yi Wang, Ph.D.

R&D expertise: Development and manufacture of biotechnology drug products and biotech wares. R&D collaboration: ROVI GmbH, Chongqing Hezhong Industrial Corp. (China), Zandu Pharmaceutical Works Ltd. (India). Technological expertise: E, BA, CB, C/TC, D-D, HTDS, PMC, P/S, BI, R, H/CF

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Principal products/instrumentation: Aloesin, skin whitener; Irnmuno-10, immunomodulator and skin melanoma preventative; UP828, therapeutic treatment for hemorrhoids and chronic venous insufficiency; UP540, monsteroidal anti-inflammatory drugs. Main products/instrumentation under R&D: Gene expression, R&D; naturally derived therapeutic products, biotechwares, other biotechnology drugs.

2815

Key license and trade contracts: Shell Development, Texaco, Bio-Imaging Research, British Technologies. Technological expertise: PMC Principal products/instrumentation: NMR spectrometers, CT scanners. Main products/instrumentation under R&D: NMR spectroscopy technologies. Sealed and granted patents: Licensed patents from original equipment or oil companies listed above.

UNIVERSAL DNA, INC.

Add: PMB 415, 13500 SW Pacific Hwy. Tigard, OR 97223 Tel: (800) 768-8744 Fax: (800) 768-8744 President: G. Walker R&D expertise: Research and manufacture of custom DNA synthesis. Technological expertise: SY Principal products/instrumentation: Contract manufacturing DNA synthesis products. Main products/instrumentation under R&D: DNA binding protein, DNA cloning vector.

2817

UNIVERSAL SENSORS, INC.

Add: 5258 Veterans Blvd., Ste. D Metairie, LA 70006-5131 Tel: (504) 885-8443 Fax: (504) 885-8443 E-mail: [email protected] President: George G. Guilbault, Ph.D. Research director: Glen Lubrano R&D expertise: R&D, manufacture and sales of instrument in the areas for piezoelectric and electrochemical biosensors and immunology. Technological expertise: PA, P/S, SMC, SY, BME

2816

UNIVERSAL MEDICAL SYSTEMS, INC.

Add: 29500 Aurora Rd., #16 Solon, OH 44139 Tel: (440) 349-3120 Fax: (440) 498-2188 E-mail: [email protected]

Principal products/instrumentation: Enzyme Electrodes, Piezoelectric Detector, Amperometric Biosensor Detector, Piezoelectric Immuno-Biosensor Detector. Main products/instrumentation under R&D: Electrochemical biosensors, piezoelectric instruments.

President: D.R. Zavagno Research director: Don Bouchard R&D expertise: Research/development of NMR spectroscopy techniques and CT scanning functions. Key sales market contracts: Resonance Instruments.

2818

UNIZYME LABORATORIES A/S

Add: Dr. Neergaardsvej 17, DK-2970 Horsholm, Denmark Tel: (45) 45-760-154 Fax: (45) 45-761-407

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E-mail: [email protected] Web site: www.unizyme.dk President: John Pedersen

883

U.S. patent pending; PERK™ Fries, U.S. patent #5,681,931; Selection Valve, U.S. patent #5,41938.

Research director: John Pedersen R&D expertise: Research of protein chemistry, gene expression, protein purification, enzymes, enzymatic methods.

2820

UPFRONT CHROMATOGRAPHY A/S

Technological expertise: E, RD, LP, BA, P/S, RPP, P/PS, PPAT, PC, ET, ERT

Add: Lerso Parkalle 42 Copenhagen 2100 Denmark

Principal products/instrumentation: Biologicals, enzymes, TAGZYME™ System for enzymatic removal of polyhistidine tags, Dipeptidyl Aminopeptidase I, Pyroglutamyl Aminopeptidase; Glutamine Cyclotransterase.

Tel: (45) 39-273-763

Main products/instrumentation under R&D: Gene expression system, protein purification technologies.

President: Allan Lihrne

2819

UPCHURCH SCIENTIFIC

Add: 619 Oak St, Oak Harbor, WA 98277 Tel: (800) 426-0191 Fax: (800) 359-3460 E-mail: [email protected] Web site: www.upchurch.com President: Alan Schell R&D expertise: Development and manufacture of of fittings, tubing and accessories for drug research lab equipment market Technological expertise: BME, BP Principal products/instrumentation: Fingertight fittings; Super Flange-less™ fittings; Microtight® fittings; Bottom-Of-The-Bottle® filters; 2-Chrom™, Mega™ and OmegaChrom™ columns. Sealed and granted patents: Bottom-Of-TheBottle™, U.S. patent #5,366,620; Check Valves, #4,846,218; Quick Disconnect™, U.S. patent #5,472,598; Quick Release Guard Cartridges, U.S. patent #5,482,628 and U.S. patent #5,621,885; Micro Valves and Perrule Clusters,

Fax: (45) 39-273-111 E-mail: [email protected] Web site: www.upfront-dk.com Research director: Allan Lihme R&D expertise: R&D of bioprocess engineering, protein purification, traditional and fluidized bed chromatography, specialty enzymes. Technological expertise: P/S, RD, LP, PMC, E, MAE, PA Principal products/instrumentation: FastMabs™ (effective “protein A” mimicking media), Upfront Media (density controlled media: normal, floating and sedimenting), Fluidized Bed Columns and Fluidized Bed Plot Plant, Enzymes, monoclonal antibodies. EBABased Disposable Chromatography Column: MabDirect MM Fixed-D 50 mL is a disposable chromatographic column based on the Expanded Bed Adsorption platform, Rhobust™. The pre-packed, pre-sanitized antibody purification columns eliminate the need for pre-filtration steps required by conventional columns. The column units are stable to 1 M NaOH solution, enabling easy and effective cleaning between cycles, 2009. Main products/instrumentation under R&D: Fluidized bed chromatography, specialty enzymes. Sealed and granted patents: Fluidized Bed Chromatography, Protein A Mimerics.

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UPSTATE BIOTECHNOLOGY, INC.

Sealed and granted patents: Rhizosheric Bacteria U.S. 5,427,785; Improved Biological Nitrogen Fixation Australia 636565.

Add: 10 Old Bam Rd. Lake Placid, NY 12946 Tel: (800) 233-3991 Fax: (781) 890-7738 E-mail: [email protected]

2823

UROCOR, INC.

President/CEO: Sheridan G. Snyder

Add: 840 Research Pkwy. Oklahoma City, OK 73104

Research director: Gregory Moore, Ph.D.

Tel: (405) 290-4000

Subsidiary of Argonex

Fax: (405) 290-4084

R&D expertise: Production and sale of antibodies, peptides and proteins for cell signal transduction research.

President/CEO: William A. Hagstrom

Technological expertise: F, PA, D-D, RD, AB, P/S, H/CF, SY, C/TC

R&D expertise: Disease management for urological conditions.

Principal products/instrumentation: Biologicals, reagents, antibodies, peptides, proteins for cell signal transduction research.

Technological expertise: PA, Q, BI, C/TC, CH/S, GA, RD

2822

Research director: Robert Veltri

Principal products/instrumentation: Antiviral agent, antiviral drugs, antiviral peptide, antiviral immunity therapy.

URBANA LABORATORIES/ RESEARCH SEEDS

Add: P.O. Box 1393 310 S. Third St. St. Joseph, MO 64501

2824

UROGENE S.A.

Tel: (816) 233-3446

Add: Genopole 4 Rue Pierre Fontaine Evry, Ile de France 91000 France

Fax: (816) 233-8295

Tel: (33) 1-6087-8980

E-mail: [email protected]

Fax: (33) 1-6087-8989

President: Bart Thedinger

E-mail: [email protected]

Research director: Tom Wacek R&D expertise: Development and production of nitrogen fixing (Rhizobium) seed inoculants. Technological expertise: F, RD, AF, BA, C/TC, PMC, P/S Principal products/instrumentation: Dormtal, Rhizo-Stick, Rhizo-Flo, Liqui-Prep, Frozen-Prep, USDA Patented Soybean Strain, Nature’s Aid. Main products/instrumentation under R&D: Genetically engineered Rhizobium meliloti; all field work completed, awaiting commercialization decision from EPA.

Web site: www.urogene.com President: Philippe Berthon C Research director: Alain Latil R&D expertise: Research of functional genomics in urology, related novel products manufacture. Technological expertise: PA, AB, BI, P/S, T, GA, RD, GT, R, G, C/TC, H/CF, CH/S Principal products/instrumentation: Genomic DNA, genomic marker, genomic mapping, genomic library.

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2825

UROGENESYS, INC.

Add: 1701 Colorado Ave. Santa Monica, CA 90404 Tel: (310) 820-8029 Fax: (310) 820-8489 E-mail: [email protected] President/CEO: Donald B. Rice Research director: Aya Jakobovits, Ph.D. R&D expertise: Early stage disease biotech diagnostic research, therapeutic and diagnostic products for urological cancers, focus on prostate cancer. R&D collaboration: Research collaborations: UCLA, Johns Hopkins, Ludwig Institute, Hutchinson Institute, University of Toronto. Key license and trade contracts: UCLA (in license 5 patent applications).

Technological expertise: BME, SI, HC Principal products/instrumentation: Tip One pipet tip system, filter tips, single and multichannel pipettors, personal magnetic stirrers and shakers, freezer boxes and racks, tubes and vials, tube labels; radiation safety products, dry heat baths, gloves, electrophoresis equipment, thin-walled microreaction tubes for DNA amplification. Subsidiary bodies: 184 Riverview Ave., Unit 3, Waltham, MA 02154, U.S.A.; 1242 Commerce Ave., Unit E, Woodland, CA 95776, U.S.A.

2827

USB CORPORATION

Add: 26111 Miles Road, Cleveland, OH 44128 Tel: (216) 765-5000 Fax: (216) 464-5075 E-mail: [email protected]

Technological expertise: G, PA, RD, BI, CB, Q, T, C/TC, GA, GT, H/CF, PIS, PG, P/S

Web site: www.usbweb.com

Main products/instrumentation under R&D: Validated antigen targets for cancer drug development, preclinical; diagnostic and therapeutic drugs (prostate cancer).

Research director: Bruce Moffett

Sealed and granted patents: Multiple applications pending.

2826

885

President: Dr. Phil Douglas Technological expertise: E, F, Q, BME Principal products/instrumentation: Specialty chemicals, thermo sequenase kits, TUF enzymes, detergents, diagnostics, reagents, ultrapures sequenase, miRtect-IT™ miRNA Labeling and Detection Kit, 2007.

USA SCIENTIFIC, INC.

Add: Ocala, FL 34478-3565 Tel: (352) 237-6288

2828

U.S. FILTER

Fax: (352) 351-2057

Add: 4669 Shepherd Trail P.O. Box 560 Rockford. IL 61105-0560

E-mail: [email protected]

Tel: (815) 877-3041

Web site: www.usascientific.com

Fax: (815) 877-0172

President/CEO: Robert Declerk

President: Richard J. Heckmann

Research director: Woody Moser

Research director: Dave Moyer

R&D expertise: Development, manufacture and marketing of plastic ware, acrylics, and benchtop tools for life science laboratories.

R&D expertise: Development and products of all types of filters for drug research. Joint ventures: Nalco Chemical Co.

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Technological expertise: F, BME

President: Leighton Smith

Principal products/instrumentation: Filter, filterpress, filtrator, filtration manifold, filter membrane.

R&D expertise: Development and manufacture of ultraviolet lamps and related equipment plus gel documentation and image analysis products.

2829

U-VISION BIOTECH, INC.

Add: 10th F1.72 Sung-Te Rd. Taipei 11022 Taiwan Tel: (886) 2-8780-4558 Fax: (886) 2-8780-4597 President/CEO: Michael Tseng Research director: Dr. Eric Tseng R&D expertise: R&D and production of BioChips (Microarray). Joint ventures: UniMed, Inc., Taipei, Taiwan; Prisma Biotechnology Co. Ltd., Taipei, Taiwan.

Technological expertise: BME, AMS, SI Principal products/instrumentation: Imaging System for Gels and Plates, 2007. Main products/instrumentation under R&D: 3UV transilluminator, image analyzed microscopy. Subsidiary bodies: Unit 1, Trinity Hall Farm Estate, Nuffield Rd., Cambridge CB4 1TG, U.K. Sealed and granted patents: Three UV Transilluminator.

2831

V & P SCIENTIFIC, INC.

R&D collaboration: Incubation Center, National Yang Ming Medical University, Taipei, Taiwan; National Health Research Institute, Taipei, Taiwan (under negotiation).

Add: 9823 Pacific Heights Blvd., Ste. T, San Diego, CA 92121

Key sales market contracts: UniMed, Inc., Taipei, Taiwan.

Fax: (858) 455-0703

Key license and trade contracts: Academia Sinica, Taipei, Taiwan.

Web site: www.vp-scientific.com

Technological expertise: Q, BI, GA, G, SY, PG Main products/instrumentation under R&D: In vitro toxicology testing method, contract research/clinical trial products, Colorimetric high-density cDNA microarray membranes, (pilot beta-version under testing), biochips (microarray).

2830

UVP, INC.

Add: 2066 W. 11th St. Upland, CA 91786 Tel: (909) 946-3197 Fax: (909) 946-3597 E-mail: [email protected] Web site: www.uvp.com

Tel: (858) 455-0643 E-mail: [email protected] President/CEO: Patrick H. Cleveland, Ph.D. Research director: Patrick H. Cleveland, Ph.D. R&D expertise: R&D and manufacture of biomedical laboratory equipment/instrumentation and biotechwares for biotech drugs research. Technological expertise: GA, G, HTDS, PG, P/S, RD, R, Q, SMC, AF, BME Key sales market contracts: Nalge Nowee International. Principal products/instrumentation: Multiblot Replicators, Alligator Tumble Stirrers, Levitation Stirrers. Main products/instrumentation under R&D: Biomedical laboratory equipment, microarrayer, biotech wares.

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Sealed and granted patents: Microarrayer 6, 613, 284, U.S.

887

Therapies, Inc.; Onxy Pharmaceuticals, Inc.; Bayer Corporation, Inc. R&D collaboration: As above.

2832

VACOLD, LLC.

Key sales market contracts: As above. Key license and trade contracts: As above.

Add: 360 Lexington Av., 21st Floor New York, NY 10017

Technological expertise: BA, C/TC, CH/SDD, D-D, GT, PG, P/S, RD, SY, Q

Tel: (212) 599-4455

Main products/instrumentation under R&D: IL-2, Phase IIIb; IFN-alpha gene medicine (gene herapy) for treatment of malignant endothelioma, Phase IIIa; EL-12, Phase IIIa; H-2+chemotherapy, Phase IIIb; IL-12+IFN combination, preclinical; IL-2+Superantigen A, Phase IIa; IL-2+superantigen A gene medicine, for treatment of melanoma, in clinical trials. BRCA-1, preclinical; Angiogenesis inhibition, preclinical; Systemic (IV) cytokine, preclinical; VEGF-165, gene medicine for treatment of restinosis in coronary artery and peripheral vascular diseases, Phase III; del-1, preclinical; ENDS, preclinical; Factor IX, preclinical; EPO, preclinical; CFTR, Phase II completed; Undisclosed genes, preclinical; infectious diseases therapeutics, research/preclinical; ONYX-015, preclinical; Factor VIII, preclinical; Secreted proteins, preclinical.

Fax: (212) 599-4496 President: David Dove, M.D. Research director: Cohava Gelber, Ph.D. R&D expertise: Research of antigen and antibody discovery, related applied novel products development. Technological expertise: PA, C/TC, H/CF Main products/instrumentation under R&D: Contract manufacturing products, Antimyeloma monoclonal antibody, preclinical; antigen and antibody discovery route. Subsidiary bodies: Vacold, LLC (Laboratory) 765 Old Saw Mill River Rd., Suite 100, Tarrytown, NY 10591 Tel: (914) 345-0500, Fax: (914) 345-0020.

2833

VALENTIS, INC.

Add: 863A Mitten Rd. Burlingame, CA 94010 Tel: (650) 6971-900 Fax: (650) 6524-980 E-mail: [email protected] Web site: www.valentis.com President/CEO: Benjamin McGraw III Research director: Akin Rolland R&D expertise: Research of biologies delivery technology, and related applied products development/manufacture. Joint ventures: Roche Holdings, Ltd; Eli Lilly & Co.; Glaxo Wellcome PLC; Boehringer Ingelheim, International GmbH; Cardiogene; Heska Corporation; Invitrogen; Transkaryotic

Subsidiary bodies: Valentis, Inc. — The Woodlands Center, 8301 New Trails Drive, The Woodlands, TX 77381-4248; PolyMASC Pharmaceuticals, Fleet Road, London, NW3 2EZ, U.K. Sealed and granted patents: Gene delivery with cationic lipids and other materials; GeneSwitch™ for regulated expression; tissuespecific plasmids; manufacturing (~2001); Cationic lipid: DNA complexes for gene targeting. 6, 344,446, U.S.; Protected one-vial formulation for nucleic acid molecules, methods of making the same by in-line mixing, and related products and methods. 6,534,483, U.S.; Process and equipment for plasmid. 7,026,468, U.S.; Formulated nucleic acid compositions and methods of administering the same for gene therapy. 6,514,947, U.S.

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VALIDATION SYSTEMS, INC.

R&D expertise: Discovery and development of gene repair therapies.

Add: 988 San Antonio Rd. Palo Alto, CA 94303-49-17

Key license and trade contracts: Pioneer Hi-Bred.

Tel: (650) 856-4874

Technological expertise: C/TC, CH/S, GT, DDI

Fax: (650) 856-4876 E-mail: [email protected] Web site: www.validationsystems.com President/CEO: Les Bowker R&D expertise: R&D of bioprocess engineering, validation and medical devices. Joint ventures: Smite Engineering, Brussels, Belguim. Technological expertise: C/TC, LP, GA, RD, BA, F, E, quality assurance, facility design, validation laboratory testing services.

Main products/instrumentation under R&D: Gene repair therapy, preclinical; gene replacement therapy. Sealed and granted patents: U.S. Patent No. 5,565,350.

2836

VALLEY RESEARCH, INC.

Add: 3502 North Olive Road,, South Bend, IN 46628

Principal products/instrumentation: Validation of all areas and test methods, laboratory testing at our independent testing facility.

Tel: (574) 232-5000

Main products/instrumentation under R&D: Bioprocess technology, methods for detection of nucleic acid polymorphism.

Web site: www.valleyenzymes.com

Subsidiary bodies: 9605 Scranton Rd., #101, San Diego, CA 92121; Brussels, Belgium. Sealed and granted patents: Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays. 6,403,309, U.S.; Single-stranded Oligodeoxynucleotide Mutational Vectors. 6,271,360, U.S.; other patents are pending.

Fax: (574) 232-2468 E-mail: [email protected] R&D expertise: Development and production of food enzymes. Technological expertise: E, ET, ERT Principal products/instrumentation: food processing, nutraceuticals, Pectinase, crystalzyme®, Protease, Validase™. Main products/instrumentation under R&D: Novel food enzymes.

2837 2835

VALIGEN

VANCOUVER BIOTECH, LTD.

Add: 300 Pheasant Run Newtown, PA 18940

Add: 9121 Shaugnessy St. Vancouver, British Columbia V6P 6R9 Canada

Tel: (215) 504-4444

Tel: (604) 325-4602

Fax: (215) 504-4545

Fax: (604) 325-4677

Web site: www.valigen.com

E-mail: [email protected]

President/CEO: Gerald L. Messerschmidt, M.D.

Web site: www.vancouverbiotech.com

Research director: Mike Blaese, M.D

Research director: Dr. Gregory Lee

President: Dr. Gregory Lee

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R&D expertise: R&D and production of monoclonal antibodies and immunodiagnostics.

Fax: (919) 677-1138

Technological expertise: MAE, AB

Research director: Allan Little

Principal products/instrumentation: Customized monoclonal antibodies for immunological diagnostic kits, markers for the prostate and ovary cancer.

R&D expertise: Development and manufacture of pharmaceutical testing instrumentation.

Main products/instrumentation under R&D: Immunodiagnostic reagents, immunodiagnostic enzymes.

2838

VANGUARD MEDICA, LTD.

Add: Chancellor Ct. Surrey Research Park Guildford, Surrey GU2 5SF U.K. Tel: (44) 148-878-7878 Fax: (44) 148-378-7811 President/CEO: Robert G. Mansfield Research director: Dr. John Fromson R&D expertise: Pharmaceutical development, related applied novel products manufacture. Joint ventures: SmithKline Beecham, Eli Lilly. R&D collaboration: Smithkline Beecham, Eli Lilly, Strathclyde Institute for Drug Research, University College of London. Key sales market contracts: SmithKline Beecham. Key license and trade contracts: BTG. Technological expertise: AF, SY, SMC, DD, D-D Principal products/instrumentation: Biologicals, pharmaceuticals, vaccines, reagents, antibodies, and other biopharmaceuticals.

President/CEO: Jim Swon

Joint ventures: Hewlett Packard Channel Partner; Zymark, Varian, Perkin Elmer and Thermo-Separation Corporate Partners. Technological expertise: DD, D-D, BME Principal products/instrumentation: VK7000 Dissolution Testing Station, VK7010 Dissolution Testing Station, Bio-Dis™ Extended Release Tester, VK8000 Dissolution Sampling Station, VK100 Tablet Disintegration Tester, VK200 Tablet Hardness Tester, Tap Density Tester, Friabilator, Peak Vessel™. Main products/instrumentation under R&D: Pharmaceutical testing novel instruments. Subsidiary bodies: Vankel International, Ltd., Sopwith House, Sopwith Crescent, Wilkford Business Park, Essey SS11 8YU, U.K.

2840

VANSON LP.

Add: 8840 152nd Ave. N.E. Redmond, WA 98034 Tel: (206) 881-6464 Fax: (206) 882-2476 President: Joel Van Omum Research director: Everett Nichols, Ph.D. R&D expertise: R&D and manufacture of chitin/chitosan-based products. Joint ventures: DuPont R&D collaboration: DuPont

2839

VANKEL TECHNOLOGY GROUP

Add: 13000 Weston Pkwy, Gary, NC 275132228 Tel: (919) 677-1108

Key sales market contracts: DuPont. Key license and trade contracts: DuPont. Technological expertise: E, AF, CB, DD, D-D Principal products/instrumentation: Chitin, Chitosan, contract manufacturing products.

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VAPONICS PRODUCTS/ OSMONICS

Add: 5951 Clearwater Dr. Minnetonka, MN 55343-8995

2843

VARIAN INSTRUMENTS

Add: P.O. Box 954 Dept 87 Santa Clarita, CA 91380 Tel: (800) 926-3000

Tel: (800) 848-1750

Fax: (281) 240-6752

Fax: (612) 933-2277 Research director: David Paulson

R&D expertise: R&D and production of biomedical equipment/instrumentation, biotechwares, etc for biopharmaceutical research.

Subsidiary of Osmonics, Inc.

Technological expertise: BME, C/TC, AB

R&D expertise: R&D and manufacture of high quality ultrapure water equipment, including distillation, pure steam generation, ion exchange, ultrafiltration, reverse osmosis, and ozonation.

Principal products/instrumentation: UVVis-NIR spectrophotometers, NMR spectrometers, gas and liquid chromatographs, solid phase extraction products, Bond Elut Certify.

Technological expertise: P/S, BME

Main products/instrumentation under R&D: Biomedical equipment, biotech wares for biopharmaceutical research.

President/CEO: D. Dean Spate

Principal products/instrumentation: Specialty purification treatment. Main products/instrumentation under R&D: High quality ultrapure water equipment, ultrafiltration fermenter, chemicals, food processing, cosmetics.

2842

VARIAGENICS, INC.

2844

VAR-LAC-OID CHEMICAL CO., INC.

Add: 13 Foster St. P.O. Box 181 Bergenfield, NJ 07621 Tel: (201)387-0038

Add: 60 Hampshire St. Cambridge, MA 02139-1562

Fax: (201) 387-0291

Tel: (617) 588-5300 Fax: (617) 588-5399

R&D expertise: Cesium compounds and high purity metals, metal powders and compounds.

E-mail: [email protected]

Technological expertise: CS, P/S

Web site: www.variagenics.com

Principal products/instrumentation: Cesium compounds; cesium chloride (diagnostics).

President: Taylor J. Crouch Research director: Fred D. Ledley, M.D. R&D expertise: Research and development of novel pharmaceutical products targeted to the normal genetic variation of human populations.

President: A.M. Kessler

Main products/instrumentation under R&D: High purity cesium metal powders.

2845

VECO INTERNATIONAL

Technological expertise: Q, BI, C/TC, D-D, RD Principal products/instrumentation: Biopharmaceutical products.

Add: 24543 Indoplex Circle Farmington Hills, MI 48335

Main products/instrumentation under R&D: Drug targeted to normal genetic variation.

Tel: (313) 442-7620 Fax: (313) 442-0060

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President: John Greenstreet

Tel: (248) 478-5820

R&D expertise: Development and manufacture of cleanroom architectural and mechanical components for the pharmaceutical and biomedical industries.

Fax: (248) 442-0060

Technological expertise: BME, CS, CSDP Principal products/instrumentation: MRC System 1200 (modular cleanroom); Kleenedge™ Air Curtain; 3000 Clean Wall System; Laminar Flow Hoods, Barriers, Isolators, Dust Containment Cabinets.

2846

VECTAGEN, INC.

891

E-mail: [email protected] Web site: www.vectech.com President: Allan Pfitzenmaier R&D expertise: Development and manufacture of pharmaceutical/biomedical/medical devices consultation and engineering research. Technological expertise: BME, C/TC, E, F, GA Principal products/instrumentation: Kleenedge. Sealed and granted patents: Kleenedge vertical flow module.

Add: 216 Jaffa Rd. Jerusalem 94383 Israel Tel: (972) 2-537-4997

2848

VECTOR LABORATORIES, INC.

Fax: (972) 2-537-5098 CEO: Dr. Yoni Barnhard R&D expertise: Research of gene therapy for cancer treatment, cancer diagnosis, and telemolecular pathology; related therapertic drugs development and manufacture.

Add: 30 Ingold Rd. Burlingame, CA 94010 Tel: (650) 697-3600 Fax: (650) 697-0339 E-mail: [email protected] Web site: www.vectorlabs.com

R&D collaboration: Hebrew University, Jerusalem; Sd. Collaborations: Case Western Reserve University Medical School (Prof. H. Tykocins); Free University, Berlin, Germany (Prof. V. Endmann).

President: James S. Whitehead, Ph.D.

Technological expertise: D-D, GT, PG

Key sales market contracts: Novocastra Laboratories, BBI.

Main products/instrumentation under R&D: Gene therapy vectors, preclinical; molecular diagnostics, methods for inducing tumorspecific cytotoxicity, telemolecular pathology, technology. Sealed and granted patents: “Methods for Inducing Tumor-Specific Cytotoxicity”.

2847

VECTECH PHARMACEUTICAL CONSULTANTS, INC.

Add: 26105 Orchard Lake Road, Suite 311, Farmington Hills, MI 48334

Research director: Laurence J. Mclntyre, Ph.D. R&D expertise: Development and production of non-radioactive detection systems.

Key license and trade contracts: Stanford University, University of California, Bresatech. Technological expertise: PA, DK, E, ET, FL, AB, NAC Principal products/instrumentation: Lectins, biotin/avidin detection systems, antibody conjugates, Vectastain® ABC kits, Photoprobe™ biotin, and other nucleic acid labeling reagents; expression library screening reagents; transfer blot and enzyme immunoassay systems; Vectrex™ avidin for DNA/RNA isolation; Neurobiotin Tracer, Vectabond™ tissue adhesive, AMCA™, and other fluorochrome conjugates;

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Vectashield™ mounting medium, OEM reagent and kit.Vectastain® Universal Quick Kit, Fast Tag™ DNA/RNA/Oligo Labeling Systems, VECTASTAIN™ Universal Elite ABC Kit, The IrnmEdge™ Pen, Vector® Mouse on Mouse (M.O.M.™) Immunodetection kit; DuoLux™ Chemiluminescent Substrate; Vector® Nova Red Peroxidase Substrate; Vectamount™ Permanent Mounting Medium; Ready-to-Use (R.T.U.) Solution formats of the VECTASTAIN™ Elite and Quick kits. Main products/instrumentation under R&D: Molecular biology reagents, non-radioactive labeling, non-radioactive detection systems with enhanced sensitivity, DNA/RNA labeling and detection reagents, lectins. Subsidiary bodies: Vector Laboratories Ltd., 3 Accent Park, Bakewell Rd, Orton Southgate, Peterborough PE2 6XS, U.K., Tel: (44) 0173323-7999, Fax: (44) 017-3323-7119, E-mail: [email protected]; Vector Laboratories (Canada), Inc., 3390 South Service Rd., Burlington, ON, Canada L7N 3JS, Tel: (905) 681-0900, Fax: (905) 681-0166, E-mail: [email protected]. Sealed and granted patents: 4,684,609 and 5,700,921.

2849

VEE GEE SCIENTIFIC, INC.

Add: 13600 NE 126th Place Suite A Kirkland, WA 98034-8720 Tel: (425) 823-4518 Fax: (425) 820-9826 E-mail: [email protected] Web site: www.veegee.com President: Bonnie Brice Research director: Paul Wendling R&D expertise: Development, manufacture and wholesale provide of laboratory instruments, equipment and supplies.

Technological expertise: BME Principal products/instrumentation: ATAGO Refractometers; SIBATA Glassware; Bellwether Porcelain; Van Guard Microscopes; VEE GEE Brand Thermometers. Main products/instrumentation under R&D: Laboratory novel instruments/equipment and supplies.

2850

VELOCITY 11

Add: 435 Acacia Ave. Palo Alto, CA 94306 Tel: (650) 218-8849 Fax: (650) 846-6520 E-mail: [email protected] Web site: www.velocity11.com President/CEO: JoeBen Bevirt Research director: JoeBen Rivert R&D expertise: R&D and manufacture of automation equipment for biotech drug research. Technological expertise: R, BI, CH/S, GA, G, HTDS, P/S, SY Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products, BioCel™-2000, Vector™-2000, PlateLoc™, thermal plate sealer2000; VCode™, barcode print & apply station-2000, VPrep™, automated pipetting station-2000; VStack™, automated plate handling/stacking-2000; Flexible Robotic Platform-2000; R-Series BenchCel® Microplate Handling System, 2007; Automated plated sealer, 2008. Main products/instrumentation under R&D: High throughput ELISA platform-development, high throughput PCR Prep Platform, standalone plate, incubator, laboratory automation equipment for biotech drug research. Sealed and granted patents: Numerous technology patents.

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2851

VENTANA CLINICAL RESEARCH CORPORATION

Add: 76 Grenville St., Ste. 947 Toronto, Ontario M5S 1B2 Canada Tel: (416) 323-7552 Fax: (416) 323-7553 E-mail: [email protected] President/CEO: Dr. Edward M. Sellers, M.D., Ph.D., F.R.C.P.C. Research director: Dr. Edward M. Sellers, M.D., Ph.D., F.R.C.P.C R&D expertise: Clinical research of novel drugs.

Main products/instrumentation under R&D: VX-770 for the treatment of cystic fibrosis(CF), international Phase III, 2009; VX-478, HIV Protease Inhibitor, Phase III/IV; Incel™, Cancer MDR Reversal Agent, Phase II; VX-853, Cancer MDR Reversal Agent, Phase II; VX497, IMPDH preclinical; VX-740, Ice, preclinical; R&D programs — Neurophilins, hepatitis C, p38 MAP kinase, Caspase (apoptosis). Sealed and granted patents: Multiwell plate and electrode assemblies ion channel assays 6,969,449, U.S.; other patents are pending.

2853

Technological expertise: G, PG, PMC Principal products/instrumentation: Contract research/clinical trial products, natural products, nutraceuticals, pharmaceuticals, vaccines, reagent, antibodies.

893

VESTA PHARMACEUTICALS, INC.

Add: 5767 Thunderbird Rd., Indianapolis, IN 46236 Tel: (317) 895-9000 Fax: (317) 895-9340

2852

VERTEX PHARMACEUTICALS, INC.

E-mail: [email protected] Web site: www.vestapharm.com President: Sam Kwon, MBA

Add: 130 Waverly St. Cambridge, MA 021394242

Research director: George F. Kite, Ph.D.

Fax: (617) 444-6680

R&D expertise: Development/manufacture of pharmaceuticals and nutraceuticals, contract manufacturing products.

Web site: www.vrtx.com

Technological expertise: SMC, SY

President/CEO: Joshua Boger, Ph.D.

Principal products/instrumentation: Contract manufacturing products, nutraceuticals, pharmaceuticals/biopharmaceuticals, vaccines, reagents, natural products.

Tel: (617) 444-6100

Research director: Vicki L. Sato, Ph.D. R&D expertise: Research of advanced techniques in chemistry, biology and biophysics to develop/produce novel, orally available drugs for AIDS, cancer, autoimmune diseases, inflammation, neurodegenerative disorders and hepatitis C. R&D collaboration: Glaxo Wellcome, Hoechst Marion Roussel, Kissei Pharmaceutical Co., Ltd., Eli Lilly & Co., BioChem Pharma. Technological expertise: Q, D-D, RD, C/TC, P/S, SY

2854

VETERINARY DYNAMICS, INC.

Add: 1535 Templeton Rd. Templeton, CA 93465 Tel: (805) 434-0321 Fax: (805) 434-3840 President/CEO: Derek Brook, D.V.M.

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Research director: Rose M. Hill R&D expertise: Veterinary biologicals, including blood components (plasma, leukocytes, cryoprecipitate), custom polyclonal antibodies. Technological expertise: AB, BME, BS Principal products/instrumentation: Polymune™ equine plasma; botulism antiserum; Rhodocaccus Equi; blood and its components; plasma, red blood cells, platelets, leukocytes, cryoprecipitates, custom antibodies. Main products/instrumentation under R&D: antiendotoxemia serum, preclinical.

2855

VETERINARY INFECTIOUS DISEASE ORGANIZATION (VIDO)

Add: 120 Veterinary Rd. Univ. of Saskatchewan Saskatoon, Saskatchewan S7N 5E3 Canada Tel: (306) 966-7465 Fax: (306) 966-7478 E-mail: [email protected] Web site: www.sask.ca/vido/

Ecolan®, vaccine for calf scours; Hevlan TC™, type II adenovirus vaccine against haemorrhagic enteritis in turkeys and splenomegaly of chickens; PNEUMO-STAR™, and SOMNUSTAR Ph™, the world’s first commercial veterinary vaccines utilizing recombinant DNA technology (genetic engineering), SOMNUSTAR, commercial vaccine to control Haemophilus somnus, PLEURO-STAR-4™, a recombinant subunit vaccine for Actinobaccillus pleuropneumoniae infection in swine. Main products/instrumentation under R&D: Novel live viral and bacterial vaccines, vaccines against streptococcus suis in swine, viral vaccines for bovine respiratory disease complex, vaccine formulation and delivery systems, viral vaccines for bovine enteric infections, polynucleotide vaccines, bovine mastitis vaccines, vaccines for Escherichia coli in infection in poultry, mucosal immunity and acute-phase proteins, conducting animal health products. Subsidiary bodies: Research Farm (160 acres). Sealed and granted patents: 30 registered, 15 ready.

President: Lorne Babiuk Research director: Andrew Potter R&D expertise: R&D of biotechnological engineering, conducting animal health-related research, communicate livestock management techniques and information, and facilitate the transfer of technology for international commercial development. Key sales market contracts: VIDO, an exporter of information, services and technology internationally, is interested in continued pursuit of international exports.

2856

VETREPHARM ANIMAL HEALTH, INC.

Add: 383 Sovereign Rd. London, ON N6M 1A3 Canada Tel: (519) 453-3384 Fax: (519) 453-2418 President: Jim Atchison R&D expertise: R&D and manufacture of veterinary biologicals and pharmaceuticals.

Technological expertise: F, PA, Q, SMC, PMC, BA, C/TC, COC, DD, D-D, GA, PIS, RD, P/S, MAE

Key sales market contracts: Rimeda, Lapisa, Boehringer Ingelheim Animal Health, Inc.

Principal products/instrumentation: Vicogen™, world’s first calf scours vaccine;

Principal products/instrumentation: Agriculture, biologicals, vaccines, veterinary products,

Technological expertise: F, PA, C/TC

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Folltropin™ V, Colimune Oral®, Virabos™, Immunoboost™ K, Equimune™ IV. Main products/instrumentation under R&D: PRRS vaccine, immune stimulants (small animals and dairy), other veterinary biologicals.

2857

VIB

895

R&D collaboration: Merck & Co., vaccines and therapeutic proteins; Pasteur Merieux, vaccines; Genzyme, cystic fibrosis; Meriai, animal vaccines; Rhone-Poulenc Rorer, therapeutic proteins; Centocor, cancer vaccines, Pfizer, animal therapeutics. Key license and trade contracts: University of Michigan, gene therapy technology; University of Chicago, gene therapy technology.

Add: Rijvisschestraat 120, 9052 GENT, Belgium

Technological expertise: GT, D-D, C/TC, COC, PPAT

Tel: (32) 9-244-6611

Main products/instrumentation under R&D: Allovectin®-7, DNA/lipid complex, encoding HLA-B7 antigen, for treatment of cancer immunotherapeutic, Phase III/IV; Leuvectin DNA/lipid complex encoding IL-2, cancer immunotherapeutic, Phase III; Vaxid, cancer vaccine to treat ß-cell and mantle cell lymphomas, Phase II/III; animal vaccines, therapertic proteins, gene drugs to treat cancer, infectious disease and metabolic disorders, gp 100 cancer vaccine. TransVax therapeutic DNA cytomegalovirus(CMV)vaccine, Phase II, 2009. Phase II of angiogenesis therapy in patients with critical ischemia, the NV1 FGF therapy contains DNA encoding fibroblast growth factor 1(FGF-1), a growth factor that stimulates the growth of blood vessels, and is intended to reduce the need for amputations in patients suffering from critical limb ischemia, 2009

Fax: (32) 9-244-6610 E-mail: [email protected] Web site: www.vib.be President: Jo Bury Research director: Jan Demolder R&D expertise: Basic research of biomedical equipment for biotech drugs, applied product manufacture. Joint ventures: Urriversites of Sent, Leuven, Brussels and Antugro. Technological expertise: E, F, PA, AB, BI, P/S, BS, CB, C/TC, DD, D-D, GT, G, HTDS, GA, T Main products/instrumentation under R&D: Bio-Incubator, other biomedical equipment for biotech drugs.

2858

VICAL, INC.

Add: 9373 Towne Centre Dr. Suite 100 San Diego, CA 92121

Sealed and granted patents: 5,580,859, 5,589,466, 5,693,622, 5,703,055; formulations and methods for treatment of inflammatory diseases, 20070237740, U.S.

Tel: (858) 646-1100 Fax: (858) 646-1150 Web site: www.vical.com

2859

VIENNALAB/ LABORDIAGNOSTIKA GMBH

President/CEO: Alain B. Schreiber, M.D. Research director: Jon Norman, Ph.D. R&D expertise: R&D and manufacture of gene-based drug products to treat cancer, infectious disease and metabolic disorders.

Add: Gaudenzdorfer Guertel 43-45 Vienna A1120 Austria Tel: (43) 1-8120-156-0 Fax: (43) 1-8120-156-19

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E-mail: [email protected]

2861

VINAR BIOGENES

Web site: www.viennalab.com Research director: Robert Zeillinger, Ph.D. R&D expertise: Development and production of reagents and kits for clinical research and diagnostics, focusing on genetic testing.

Add: 201-203, Morya Estate, Andheri Link Road, Mumbai 400 053 India Tel: (91) 22-2673-0500 Fax: (91) 22-2673-0800

R&D collaboration: University of Vienna.

E-mail: [email protected]

Technological expertise: RD, GA, P/S

Web site: www.vinarweb.com

Principal products/instrumentation: Nucleic acid isolation, factor V gene mutation assay, haemochromatosis gene mutation assay, HLAB27 gene detection assay, thalassemia genotyping, prothrombin gene mutation assay.

President: Sushil Churiwala

Main products/instrumentation under R&D: Novel gene testing for clinical research and diagnostics.

2860

VIMRX PHARMACEUTICALS, INC.

Subsidiary of Vuiar Integration Limited. R&D expertise: Biotechnology research, and related gene drug products development and manufacture. Technological expertise: F, CC, TE, AF, PMC, BA, C/TC, PIS, DD Principal products/instrumentation: Human Genome Project, contract manufacturing products, reagents, vaccines, contract research/ clinical trial products, gene drug products, natural products.

Add: 2751 Centerville Rd. Suite 210 Wilmington, DE 19808 Tel: (302) 998-1734

2862

VINDUM ENGINEERING, INC.

Fax: (302) 998-3794 President/CEO: R. L. Dunning Research director: D.A. Jackson R&D expertise: R&D and manufacture of antivirals, anticancer, catalytic oligonucleotides, etc.

Add: 1 Woodview Court San Ramon, CA 94583-2307 Tel: (925) 275-0633 Fax: (925) 275-9697

Technological expertise: A, D, G, Y

E-mail: [email protected]

Main products/instrumentation under R&D: VIMRxyn: Anti-HIV, Phase II/III; Glioma, Phase II/III; Hepatitis C, Phase II/III; Blood sterilization, preclinical; chemically modified ribozyme, chimeric oligomer, loop II replacement.

Web site: www.vindum.com

Sealed and granted patents: Building Block Patent Application, Chemically Modified Ribozyme Patent Application, Chimeric Oligomers Application, Loop 11 Replacement Patent Application.

President: Jorgen Vmdum R&D expertise: Development and manufacture of laboratory instrumentation for drug research use. Technological expertise: BME Principal products/instrumentation: Quizix Pump Systems. Main products/instrumentation under R&D: Laboratory instruments for drug research use.

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2863

VIOBIN CORP/SCIENTIFIC PROTEIN LABS

Add: 700 E. Main St P.O. Box 158 Waunakee.WI 53597 Tel: (608) 849-5944 Fax: (608) 849-4053 President: Robert G. Sullivan Research director: Edward Mancilla Subsidiary of A.H. Robins Co. R&D expertise: Development and manufacture of professional products for the pharmaceutical, diagnostic, biotechnology and food industries. Technological expertise: E, P/S, ET, ERT, BS Principal products/instrumentation: Brilliant Solutions™ blood products: bovine albumin, Fraction V globulins, thrombin; pancreatin, pancrelipase, trypsin; heparins: sodium, calcium, lithium and ammonium; defatted wheat germ, wheat germ oil, Rex Oil®; dessicated and defatted liver powder; Prometol®. Main products/instrumentation under R&D: Low endotoxin and affinity purified bovine albumin Fraction V; cross-linked and activated affinity gels; glycosaminoglycans, food supplement, diagnostic reagents.

2864

VION PHARMACEUTICALS, INC.

897

anticarcinogen for cancer treatment and antiviral therapies. R&D collaboration: Yale University, Megan Health. Technological expertise: SMC, C/TC, DD, RD, GT Main products/instrumentation under R&D: TAPET™, gene therapy for cancer, preclinical; PRQMYCIN™ (porfiromycin), bioreductive agent, Phase III/IV; OCX-0189, OCX-0191, ribonucleotide reductase inhibitors, preclinical; OCX-0177, OCX-0247, alkylating agent prodrugs, preclinical; B-L-Fd4C, nucleoside analog, preclinical; B-L-FddC, nucleoside analog, preclinical; ribonucleotide reductase inhibitors, genetically modified tumor-targeted bacteria with reduced virulence. Sealed and granted patents: BETA-L-FD4C, ribonucleotide reductase inhibitors; Genetically modified tumor-targeted bacteria with reduced virulence, 6,477,784, U.S.; Methods for use of genetically modified tumor-targeted bacteria with reduced virulence, 6,923,972, U.S., other potents are pending.

2865

VIRAGEN, INC.

Add: 865 SW 78th Ave. Ste. 100 Plantation, FL 33324-3212 Tel: (954) 233-8746 Fax: (954) 233-8743

Add: Four Science Park New Haven, CT 06511

President/CEO: Gerald Smith

Tel: (203) 498-4210

R&D expertise: Development, design and manufacture of multi species, human leukocyte derived natural interferon for antiviral, antiprolerative and other applications (e.g., Hep B/C, MS, Herpes, HIV/AIDS) and cancer.

Fax: (203) 498-4211 E-mail: [email protected] Web site: www.vionpharm.com President/CEO: John A. Spears Research director: Terrence Doyle, Ph.D. R&D expertise: Development, production and commercialization of anticancer drug and

Research director: Dr. Ray Ziai

Joint ventures: Scottish National Blood Transfusion Service, German Red Cross, Netherlands Red Cross, America’s Blood Centers, American Red Cross.

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Key sales market contracts: Adamjee Group.

Fax: (617) 926-9157

Key license and trade contracts: LeukoVax, in Phase I/II trials for RA

E-mail: [email protected]

Technological expertise: P/S, C/TC, G

Presiden: Dmitry Blinder

Main products/instrumentation under R&D: Omniferon™ a high-yield and highly pure natural human interferon for the therapeutic use in hepatitis B and C, multiple sclerosis, herpes, HIV/AIDS, cancer and other indications; human leukocyte derived natural interferon for antiviral.

R&D expertise: Development and production of viral diagnostic reagents, signal transduction/northern blots/RNA. Principal products/instrumentation: HIV antigens, northern blots.

Subsidiary bodies: Manufacturing plant (Edinburgh, Scotland); R&D facility (Miami, FL, U.S.A.).

Main products/instrumentation under R&D: Viral diagnostic reagents, signal transductant, northern blots.

Sealed and granted patents: Compositions of highly-purified natural mixtures of type 1 interferon derived from leukocytes and methods, 6,433,144, U.S.

Web site: www.virogen.com

Technological expertise: RD, P/S

2868

VIROLOGIC, INC.

Add: 270 E. Grand Ave. S. San Francisco, CA 94080-4811 2866

VIRAL TECHNOLOGIES, INC.

Add: 8229 Boone Blvd. Ste. 802 Vienna, VA 22182

Tel: (650) 6354-100 Fax: (650) 635-1111 E-mail: [email protected]

Tel: (703) 506-9460

President/CEO: Martin H. Goldstein

Fax: (703) 506-9471

Research director: Christos J. Petropoulos

President/CEO: Geert Kersten

Technological expertise: P/S, SY

R&D expertise: R&D of phenotypic susceptibility assay technology, broadly applicable to detect viral diseases such as HTV, hepatitis B, hepatitis C, herpes viruses, and cancer; phenotypic susceptibility assay; directed at HIV/AIDS, R&D and production of particular antiviral.

Principal products/instrumentation: Vaccine for AIDS

Technological expertise: Q, BI, BA, C/TC, CH/S, RD, D-D, GT, HTDS, PG, PMC, P/S, R

Main products/instrumentation under R&D: Segment of HIVp17 proteins.

Principal products/instrumentation: HIV Phenotypic drug susceptibility assay, PhenoSense™ HIV.

Research director: Prem Sarin, Ph.D. R&D expertise: Development and manufacture of HGP-30W, a segment of HIV p 17 protein as a vaccine for AIDS.

2867

VIROGEN

Add: 200 Dexter Ave. Watertown, MA 02472 Tel: (617) 926-9167

Main products/instrumentation under R&D: Phenotypic drug susceptibility assays for viruses such as HBV, HCV, Herpesvirus; methods for determining antiviral drug susceptibility.

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Sealed and granted patents: Patent applications have been filed worldwide; Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening, 6,942,969, U.S.

899

Tel: (800) 582-0077 Fax: (952) 563-3215 E-mail: [email protected] Web site: www.viromed.com President: Bonital L. Baskin, Ph.D.

2869

VIROMED BIOSAFETY LABORATORIES

Add: 1667 Davis St. Camden, NJ 08104 Tel: (856) 966-8000 Fax: (856) 966-1132 President/CEO: Conrad J. Heilman, Jr., Ph.D. Research director: Conrad J. Heilman, Jr., Ph.D. R&D expertise: Biosafety testing research and validation services for the biopharmaceutical industry; development of viral detection method and models.

Research director: Neal T. Wefherali, Ph.D. R&D expertise: Contract research of biosafety laboratory, offering cGLP/cGMP compliant testing supporting discovery, safety analysis, manufacturing and clinical trials of biotechnology medicines. Technological expertise: Q, SMC, AF, BA, BS, HTDS, Principal products/instrumentation: Contract research/clinical trial products, in vitro toxicology testing methods, reagents, biomaterials, vaccines, antibodies. Subsidiary bodies: St Paul, MN; Marietta, GA; Camden, NJ; Leuven, Belgium.

Technological expertise: F, T, Q, RD, P/S, BA, H/CF, AB, GT, GA Principal products/instrumentation: Biosafety testing method for characterization of mammalian cell substrates, intermediate and final product (detection of viruses, mycoplasma, DNA; genetic analysis, tumorigenicity); process validation for removal/inactivation of viruses, DNA, mycoplasma, endotoxin; gene therapy testing protocols. Main products/instrumentation under R&D: New virus models for purification process validation, ultrasensitive PCR assays for detection of human viruses, new protocols for gene therapy, viral detection method and models. Subsidiary bodies: Quality Biotech NV, Leuven, Belgium.

2870

VIROMED LABORATORIES, INC.

Add: 6101 Blue Circle Dr. Minneapolis, MN 55343

2871

VIROPHARMA, INC.

Add: 730 Stockton Drive. Exton, PA 19341 Tel: (610) 458-7300 Fax: (610) 458-7380 E-mail: [email protected] Web site: www.viropharma.com President/CEO: Dr. Claude Nash Research director: Dr. Mark McKinlay R&D expertise: Discovery, development, manufacture and commercialization of proprietary antiviral pharmaceuticals. Key license and trade contracts: Sanofi — Synthelabo granted to ViroPharma the exclusive rights to develop and market all products related to pleconaril for use in entero and rhinovirus disease in the U.S. and Canada. Technological expertise: SMC, C/TC, CH/S, D-D, PIS, P/S, R

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Main products/instrumentation under R&D: Pleconaril, viral meningitis, Phase III/IV; Pleconaril, viral respiratory infection, Phase II/III; VP 50406 series — HCV, preclinical; VP 14637 series — HCV, preclinical; proprietary antiviral pharmaceuticals. Sealed and granted patents: Various patents issued and/or pending in the HCV, RSV, pesutivirus and influenza

Main products/instrumentation under R&D: Laser projectors for drug industries. Sealed and granted patents: Applied for 3 patents.

2874

VIRTIS CO.

Add: 815 Route 208 Gardiner, NY 12525 Tel: (845) 255-5000

2872

VIROSTAT, INC.

Fax: (845) 255-5338 Web site: www.virtis.com

Add: P.O. Box 8522 Portland, ME 04104

President: Jerry Bart

Tel: (207) 856-6620

Research director: Ted Sutherland

Fax: (207) 856-6864

R&D expertise: Research, development and production of professional instrumentation for biotechnology/pharmaceutical sciences.

Web site: www.virostat-inc.com President: Douglas J. McAllister, Ph.D. R&D expertise: Development and manufacture of infectious diseases therapeutics. Technological expertise: P, B, H/CF, P/S, BA Principal products/instrumentation: Omnitope, Monotope, Lymescan.

2873

VIRTEK VISION, INC.

Add: 300 WildwoodAve. Woburn, MA 018016819 Tel: (781) 933-3456

Technological expertise: F, BME, CB Principal products/instrumentation: Benchmark and Genesis pilot-scale freeze dryers; lab-scale freeze dryers; Virtishear™ mechanical homogenizers; lab-scale fermenters and bioreactors. Main products/instrumentation under R&D: Professional instruments for biotechnologies.

2875

VIRTUAL GENOMES

Fax: (781) 933-3461

Add: 89 Rue Henri RocReFort Evry 91000 France

President/CEO: Jim Crocker

Tel: (33) 1-6936-6700

Research director: Herman DeWeerd

Fax: (33) 1-6936-6701

Subsidiary of Virtek Vision, Intl. Inc.

E-mail: [email protected]

R&D expertise: R&D of laser projectors for drug industry, related applied products manufacture.

President: P. Marliere

Technological expertise: R, SMC, RD, C/TC, COC, GA, HTDS, PG Principal products/instrumentation: Microarray Reader, ChipReader.

Research director: P. Marliere R&D expertise: Design and development of metabolic pathways, and make genetic constructions for industrial applications in biosynthesis of fine chemicals and bioremediation. Joint ventures: Evologic GmbH.

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901

Technological expertise: CC, E, SMC, SY, T, BI, BA, C/TC, CH/S, GA, G, PMC, RD, R, COC

R&D expertise: Transgenic animals, gene targeting and animal behavioral studies, related products production.

Main products/instrumentation under R&D: Genetic constructions, R&D; culture fermenters, R&D; genetic construction in drug biosynthesis.

R&D collaboration: Tartu University.

2876

VIRX, INC.

Add: 1375 Sutter St., Suite 407 San Francisco, CA 94109 Tel: (415) 474-4440

Contract Unit of License: Trade Tartu University. Technological expertise: Q, T, C/TC, GT, G, H/CF, RD Principal products/instrumentation: Biologicals, contract manufacturing/clinical trials products. Main products/instrumentation under R&D: Transgenic animal model, gene targeting technologies.

Fax: (415) 474-0720 E-mail: [email protected] Web site: www.virx.com President: William Lang, M.D. Research director: William Lang, M.D.

2878

VISIBLE GENETICS, INC.

Add: 700 Bay St. Suite 1000 Toronto, Ontario M5G 1Z6 Canada

R&D expertise: Research of clinical trial site, antiviral, vaccine and gene therapy, drug products development.

Tel: (416) 813-3240

Technological expertise: GT, CH/S

CEO: John Stevens

Main products/instrumentation under R&D: Genetherapy, Contract research/clinical trial drug, biopharmaeuticals, gene therapy, vaccines.

Research director: James Dunn

Subsidiary bodies: ViRx, Inc., Desert AIDS Project, 750 South Vella Rd., Palm Springs, CA 92264, Contact: Clayton Barbour, M.D.

2877

VISGENYZ, LTD.

Fax: (416) 813-3250 E-mail: [email protected]

R&D expertise: Development, manufacture and marketing of high performance automated diagnostic DNA sequencing systems for genes linked to disease. The OpenGene™ automated DNA sequencing system sequences 300 bases in under 30 minutes and, includes GeneObjects® DNA analysis software and a complete line of gene-specific diagnostic GeneKits.

E-mail: [email protected]

Key sales market contracts: Company has a distribution agreement with Amersham Intl. PLC to market and support a complete line of Amersham chemistry that will be optimized for the OpenGene automated DNA sequencing system.

Web site: www.visgenyx.com

Technological expertise: Q, CH/S, BTS, CB

President: Alar Karis

Principal products/instrumentation: OpenGene™ automated DNA sequencing system,

Add: P.O. Box 229, 50002 Tartu, Estonia Tel: (372) 515-5431 Fax: (372) 747-7131

Research director: Alar Karis

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MicroCel™ disposable gel cassette, MicroGene Blaster™ automated DNA sequencer, Gel Toaster™ polymerizing unit, GeneObjects™ DNA analysis software system, GeneKrts™ gene-specific diagnostic kits.

biopharmaceuticals, knowledge base.

Main products/instrumentation under R&D: GeneKits for HLA, RB1, VHL, BRCA1 and p53. The OpenGene™ automated DNA sequencing system, high performance automated diagnostic DNA sequencing systems for gene disease.

Sealed and granted patents: Differentiation of embryonic stem cells.

Subsidiary bodies: Visible Genetics, Inc. Manufacturing Facility, 29 Connell Court, Unit #2, Etobicoke, Ontario Canada M8Z 5T7, Tel: (416) 255-0256; Visible Genetics, Inc. Research & Development Facility’, 6535 Millcreek Dr., Mississauga, Ont. Canada L5N 2M2, Tel: (905) 542-8671.

Add: Stop Ford Building Oxford Road Manchester MI3 9PT U.K.

Genesis

screen

and

Main products/instrumentation under R&D: Human ES cell lines; differentiation methods of embryonic stem cells.

2880

VISUAL AUTOMATION, LTD.

Tel: (44) 161-275-5130 Fax: (44) 161-275-5145 E-mail: [email protected] President: Peter Schaeffer Research director: Patricx Courtney

2879

VISTAGEN, INC.

Add: 325 Middlefield Road Mountain View, CA 94043 Tel: (650) 237-0398 Fax: (650) 237-0397 E-mail: [email protected] President: H. Ralph Snodgrass Research director: H. Ralph Snodgrass R&D expertise: Drug discovery and leading drug prioritization based on predictive in vitro toxicology and efficacy screening, products manufacture. Key sales market contracts: Ciphergen Biosystems. Key license and trade contracts: National Jewish Medical Center. Technological expertise: G, BI, C/TC, HTDS, R Q, TE, GN Principal products/instrumentation: Contract research/clinical trial products, in vitro toxicology testing methods, organ transplants/culture,

Subsidiary of Vuman. R&D expertise: Image data management and analysis. Technological expertise: BI, CH/S, R Principal products/instrumentation: Contract research/clinical trials products, support for preclinical, Phase III and IV trials. Main products/instrumentation under R&D: Image data management and analytic system.

2881

VISUAL GENOMICS, INC.

Add: 1275 Kinnear Rd. Columbus, OH 43212 Tel: (877) 675-3727 Fax: (614) 487-3632 President: Paul P. Dymerski, Ph.D. Research director: Jeffrey Spitzner, Ph.D. R&D expertise: R&D and production of bioinformatics software and services. Technological expertise: Q, D-D, BI, GT, G, CH/S, PG

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Principal products/instrumentation: BSML Basic Browser, BSML Browser Plus, GenomXoffice, GenomXtools, DocugenX. Main products/instrumentation under R&D: Advanced GenomX tools, in testing; GenomX projectware, in development; Medinformatx software, in design; bioinformatics software.

2882

VITAGEN INCORPORATED

903

Technological expertise: P/S, C/TC, CH/S, GA, G Principal products/instrumentation: Contract R&D products. Main products/instrumentation under R&D: Medical genetic testing, DNA probes.

2884

VITA 34 GESELLSCHAFT FUER ZELLTRANSPLANTATE MBH

Add: 3344 North Torrey Pines Ct, Suite 100 La Jolla, CA 92037

Add: Deutscher Platz 5a, 04103 Leipzig, Germany

Tel: (858) 552-1522

Tel: (49) 800-034-0000

Fax: (858) 552-9169

E-mail: [email protected]

E-mail: [email protected]

Web site: www.vita34.de

Web site: www.vgen.com

CEO: Eberhard F. Lampeter, M.D.

President/CEO: C. Richard Piazza

Research director: Dietmar Egger, Ph.D.

Research director: Dr. Robert Johnson

R&D expertise: R&D of cord blood banking and products manufacture.

R&D expertise: Research and manufacture of extracorporeal liver assist device. Technological expertise: TE, C/TC, BME Main products/instrumentation under R&D: Organ transplants/culture products, ELAD™ Cartridge (extracorporeal liver assist device), in clinicals; BioAssist System — multipurpose blood pump, Phase III.

2883

VITAGEN LABORATORIES, INC.

R&D collaboration: University of Leipzig, FUTOUR — Project BEO — Berlin. Technological expertise: TE, BA, BS, C/TC, PMC Principal products/instrumentation: Contract manufacturing cord blood, contract research/ clinical trial cord blood, organ transplants/ culture, individual cord blood banking, and related technologies. Sealed and granted patents: DE197 46 610 AL.

Add: 2963 Loma Vista Road Ventura, CA 93003 Tel: (888) 354-8482

2885

V.I. TECHNOLOGIES

Fax: (805) 648-1250 President: Navnit S. Mitter, Ph.D., FABMG Research director: Dr. Navnit S. Mitter R&D expertise: Research of medical genetic testing and counseling; DNA probes-based paternity testing; preconception sperm sex selection; WHO standards based semen analysis.

Add: 134 Coolidge Ave. Watertown, MA 02472 Tel: (617) 926 1551 Fax: (617) 923 2276 CEO: John Barr Research director: John Chapman

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R&D expertise: R&D and manufacture of plasma fractionator, marketing of plasma derivatives, contract manufacture of plasma/ blood products, research of virus inactivation.

which are set up in a Science Pare (a Technopole): the Biopole Cermont-Limagne.

Joint ventures: Pall Corp., American Red Cross.

Main products/instrumentation under R&D: Toxicological diagnostics kits; natural products, nutritional products, cosmetics, xenobiotics.

R&D collaboration: JCR Pharmaceuticals, fibronectin for treatment of non-healing corneal ulcers. Key sales market contracts: American Red Cross, Pall Corp. Technological expertise: BA, /PS Principal products/instrumentation: Albumin, Factor VIII, PLAS+SD. Main products/instrumentation under R&D: Plasma fractionator, plasma derivatives. inactives universal PLAS+SD, virally inactivated RBC’s. Subsidiary bodies: Melville, New York.

Technological expertise: C/TC, RD, Q, TE, T

2887

VITRO DIAGNOSTICS, INC.

Add: 4621 Technology Drive, Golden, CO 80403 Tel: (303) 999-2130 Fax: (303) 762-1240 E-mail: [email protected] Web site: www.vitrodiag.com President/CEO: Roger Hurst Research director: Jim Musick

2886

VITRO-BIO

R&D expertise: R&D and manufacture of antigens for human diagnostics, fertility drugs.

Add: 11, Allee de la source Le Breuil Sur Gouze 63340 France

Technological expertise: F, TE, BA, CB, C/TC, PMC, P/S, RD

Tel: (33) 473-716-645

Principal products/instrumentation: 16 products in diagnostic markets.

Fax: (33) 473-716-840 E-mail: [email protected] President: R. Shrivastava, DVM, Ph.D.

Main products/instrumentation under R&D: FSH, preclinical; fertility drug fertilan, human diagnostic antigen.

Research director: R. Shrivastava, DVM, Ph.D. R&D expertise: R&D of pharmacological and toxicological in vitro diagnostics of xenobiotics/cosmetics; related products manufacture; Research, development and marketing of ayurvedic biotechnology cosmetic and nutritional products; R&D and licensing of innovative pharmaceuticals in the field of migraine, atherosclerosis and ulcers. Joint ventures: The company is a member of an association of economic trade interests of biotechnology companies, OCTOTECH GIE,

2888

VIVALIS

Add: Capus Bio-Quest, 6 rue Alain-Bombard, 44821 — Saint-Herblain cedex, Nantes — France Tel: (33) 228-073-710 Fax: (33) 228-073-711 E-mail: [email protected] Web site: www.vivalis.com President: Joseph Grimaud

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Research director: Bertrand Pain

Fax: (985) 893-0517

R&D expertise: Development and production of therapeutics proteins in eggs of transgenic birds.

E-mail: [email protected]

Key license and trade contracts: Wordwide exclusive license on Avian Embryonic StemCell (INRA/’CNRS Patent). Technological expertise: T, P/S, RD, C/TC, PIS Main products/instrumentation under R&D: Contract manufacturing products, purification products of 5 proteins expressed in white eggs from transgenic birds, therapeutic proteins in transgenic birds eggs.

2889

VIVUS, INC.

905

Web site: www.v-labs.com President: Sharon V. Veredicto Research director: John R. Veredicto R&D expertise: Development and contract manufacture of carbohydrate products and technologies service. Technological expertise: E, F, CB, D-D, P/S, SMC, SY Principal products/instrumentation: Contract manufacturing drug, natural products, enzymes for carbohydrate research, polysaccharides, medically important oligosaccharides. Main products/instrumentation under R&D: Carbohydrate binding proteins, carbohydrate fingerprinting.

Add: 1172 Castro Street, Mountain View, CA 94040-2552 Tel: (650) 934-5200

2891

VMRD, INC.

Fax: (650) 934-5389 Web site: www.vivus.com President/CEO: Leland E Wilson Research director: William Smith, Ph.D. R&D expertise: R&D and manufacture of therapeutic drugs for erective dysfunction/ urological disorders. Key sales market contracts: ASTR AB, Sweden (international distribution agreement). Technological expertise: DD, CS, COC Principal products/instrumentation: MUSE* (alprostadel). Main products/instrumentation under R&D: Therapeutic drugs for erective dysfunction/ urological disorders.

2890

V-LABS, INC.

Add: 423 N. Theard St. Covington, LA 70433 Tel: (985) 893-0533

Add: P.O. Box 502 N.W. 115 State St. Pullman, WA 99163 Tel: (509) 334-5815 Fax: (509) 332-5356 E-mail: [email protected] Web site: www.vmrd.com President: D. Scott Adams, D.V.M., Ph.D. Research director: Travis C. McGuire, D.V.M., Ph.D. R&D expertise: R&D and production of veterinary diagnostics, monoclonal antibodies, virology reagents etc. R&D collaboration: Washington State University, diagnostic research. Key sales market contracts: Cosmo Bio, monoclonal antibodies; American Bioresearch, virology products. Key license and trade contracts: Washington State University Research Foundation, diagnostic products and reagents.

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Technological expertise: E, AB, MAE Principal products/instrumentation: Diagnostics, veterinary reagents, monoclonal antibodies.

2892

catalog, a comprehensive, 2, 544-page guide to laboratory equipment, 2007. Main products/instrumentation under R&D: Novel laboratory equipment/instruments/ reagents.

VOGELBUSCH GMBH

Add: Blechturmgasse 11, Postfach 189, 1051 Vienna, Austria

2894

VYDAC/THE SEPARATIONS GROUP

Tel: (43) 1-546-61-0

Add: 17434 Mojave St Hesperia, CA 92345

Fax: (43) 1-545-29-79

Tel: (760) 244-6107

E-mail: [email protected]

Fax: (760) 244-1984

Web site: www.vogelbusch.com

E-mail: [email protected]

President: Dr. Gottfried Sodeck

President/CEO: Kervin Harrison

Research director: Dr. Schahroch Sarhaddar

Research director: Dr. Ning Mu

R&D expertise: R&D and manufacture of biotechnological engineering drug products. Technological expertise: F, LP, P/S, BA, PMC, CH/S, C/TC,

R&D expertise: R&D of biotechnological engineering, manufacture of silica and polymer HPLC columns and separations materials, reversed phase separation of polypeptides.

Principal products/instrumentation: Biologicals, multicont fermentation, cytopilot.

Technological expertise: P/S, LP, HL, DKHC, CPHC, PS

Main products/instrumentation under R&D: Biotechnological engineering drug products.

Principal products/instrumentation: VYDAC™ HPLC columns, VYDAC™ silica and polymer based separation media, VYDAC™ TP silica, VYDAC™ MS silica, VYDAC™ VHP ion exchange polymer, materials available from analytical to process scale.

2893

VWR SCIENTIFIC

Add: 1310 Goshen Pkwy. West Chester, PA 19380 Tel: (610) 431-1700

Main products/instrumentation under R&D: Silica and polymer HPLC columns and separations materials.

President: Jerry Harris R&D expertise: R&D and contract manufacture of biomedical laboratory equipment/ instrumentation/reagents, etc. Technological expertise: BME, HC, AMC, BS, CS, CW, DKHC, PI, R Principal products/instrumentation: Biologicals, specialty chemicals, cosmetics, food processing, instruments, pharmaceuticals, reagents, vaccines, scientific general lab supplies, equipment and chemicals; laboratory

2895

VYREX CORPORATION

Add: 2159 Avenida de la Playa La Jolla, CA 92037 Tel: (858) 454-4446 Fax: (858) 459-9522 E-mail: [email protected] President/CEO: Sheldon S. Hendler, Ph.D., M.D.

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Research director: Sheldon S. Hendler, Ph.D., M.D. R&D expertise: R&D and production of biopharmaceuticals and nutraceuticals.

907

Key sales market contracts: Fujisawa Pharmaceutical Co. in Japan, Kormed in Korea, Unimed in Taiwan, ImmunoDiagnostics in Australia.

Joint ventures: The Immune Response Corporation.

Key license and trade contracts: University of California covering fish with blocking DNA and unique sequence probes and CGH assays.

R&D collaboration: Uncle Bens’/Mars Corporation.

Technological expertise: F, P/S, BI, CH/S, G, GA

Key license and trade contracts: American Qualex, Invitrogen, AARP Pharmacy Services.

Principal products/instrumentation: Boilerplate.

Technological expertise: A, CC, E, F, GA, HTDS, H/CF, PIS, PG, PA, PMC, P/S, RD, Q, SMC, SY, T, AB, BI, CB, C/TC, COC, CH/S, DD, D-D

Main products/instrumentation under R&D: DNA fish probes for pre and postnatal genetics, oncology and pathology; blocking DNA and unique sequence probes.

Principal products/instrumentation: Natural products, epitope tagging products, Nutritional supplements.

Sealed and granted patents: U.S. Patent 5,447,841 — covers fish with blocking DNA and unique sequence probes. Vysis LSI, CEP and WCP direct label fluorescence probes are covered by U.S. Patent 5,491,224; Vysis CGH assays are covered by U.S. and foreign patent applications and by U.S. patent 5,447,841.

Main products/instrumentation under R&D: Panavir to treat viral diseases, Phase II; Vantox, preclinical; Vantox-N, preclinical. Sealed and granted patents: Vantox, (respiratory disease treatment); Panavir (antiviral); Cerex (delipidation); CD Tagging (functional genomics); Urushiol treatment.

2897

WAKO CHEMICALS USA, INC.

Add: 1600 Bellwood Rd Richmond, VA 23237 2896

VYSIS, INC.

Tel: (804) 271-7677 Fax: (804) 271-7791

Add: 3100 Woodcreek Dr. Downers Grove, IL 60515-5427

E-mail: [email protected]

Tel: (630) 271-7000

President: Alex Fukushima

Fax: (630) 271-7028

Research director: Emmy Leung

E-mail: [email protected]

R&D expertise: R&D and manufacture of biotechnology drug products, with focus on antibodies, enzymes, reagents, kits, cell culture media, etc.

President/CEO: John Bishop Research director: Steven Seelig, M.D. R&D expertise: Development and production of nucleic acid probes for pre and postnatal genetics and cancer. Imaging systems and software for karyotyping, fish and CGH. Joint ventures: Incyte Pharmaceuticals, Inc. and Genome Systems, Inc. to develop a comprehensive genomic map/gene mapping collaboration.

Web site: www.wako-chem.co.jp

Subsidiary of Wako Pure Chemical Industries, Ltd. Technological expertise: PI, PA, P, SY, C/TC, PIS, AB, E, DKHC, E, HC, CS, O-C Principal products/instrumentation: PLGA (Polylactic Glycolic Acid) copolymers,

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antibodies, enzymes, research reagents, research and diagnostic kits, cell culture media, Trichostatin A, Anti-AsialoG Ab, lysyl endopetidase, digitonin. Main products/instrumentation under R&D: Novel biotechnology medicines.

orientalis (ze xie), with function and indications such as “nourish yin and tonify kidney”, used for dizziness and tinnitus, sorenesstiredness of waist and knee, emission, and night sweating.

2900 2898

WALKER STAINLESS EQUIPMENT CO., INC.

WASHINGTON BIOTECHNOLOGY, INC.

Add: P.O. Box 211, Simpsonville, MD 21150 Add: 625 W. State St., New Lisbon, WI 53950

Tel: (301) 617-9901

Tel: (800) 356-5734

Fax: (301)-617-9904

Fax: (608) 562-7549

E-mail: [email protected]

E-mail: [email protected]

Web site: www.washingtonbiotech.com

Web site: www.walkerstainless.com

CEO: Sean O’Neill, Ph.D.

President/CEO: John Barsanti

Research director: Sean O’Neill, Ph.D.

Research director: Naomi Piper

R&D expertise: Testing services for pharmaceutical, immunodiagnostic industry –toxicology, polyclonal antibody production, vaccine efficacy tests, safety tests.

Subsidiary of Carlisle Companies. R&D expertise: Development and production of stainless steel equipment such as isolators and processing tanks. Technological expertise: SI, BME Principal products/instrumentation: All equipment/instrumentation of biomedical lab.

2899

WANXI PHARMACEUTICAL CO., LTD.

Technological expertise: PA, AB Principal products/instrumentation: Contract manufacturing products, diagnostics, pharmaceuticals, vaccines, veterinary products.

2901

WATERS CORP.

Add: 34 Maple St. Milford, MA 01757 Add: Zhong Jing Jiangkang Wang, Henan, P. R. China Tel: (86) 377-6353-6969 Web site: www.zjjk365.com R&D expertise: Development and manufacture of TCM. Expert in techmologies: HNT, TCM Principal products/instrumentation: Liuwei Dihuang pill is patented TCM products from poria (Fuling), Chinese yam (shan yao), dogwood fruit (shan zhu yu), rehmannia root (dihuang), moutan bark (mu dan pi) and alisma

Tel: (508) 482-2000 E-mail: [email protected] Web site: www.waters.com President/CEO: Douglas Berthiaume Research director: Bruce Compton R&D expertise: R&D and production of analytical instrumentation. Joint ventures: Source for Automation, Milford, MA; Informetrix, Seattle, WA Key sales market contracts: Gelman Sciences, Ann Arbor, MI.

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909

Technological expertise: P/S, BA, CH/S, PIS, R

E-mail: [email protected]

Principal products/instrumentation: Specialty instruments, contract research/clinical trial products, symmetry™ HPLC columns, Integrity LC/MS Capillary Ion Analyzer, Millennium® Chromatography Manager, Oligonucleotide LC Standard to the analysis of synthetic loigonucleotide DNA or RNA samples, 2008.

Web site: www.watson-marlow.com

Main products/instrumentation under R&D: Analytical grade reagents, analytical chromatograph.

Principal products/instrumentation: Various models of peristaltic hose pumps; 520 series fermentor pump for metering, dosing and transferring of fermentor nutrients in sanitary environments, 2007.

2902

WATLOW

Add: 12001 Lackland Rd. St. Louis, MO 63146 Tel: 800-WATLOW2; (800) 4WATLOW Fax: (877) 893-1005

President: James L Whalen R&D expertise: R&D and manufacture of biomedical laboratory equipment/instrumentation (with focus on various model pumps) for drug research special purpose. Technological expertise: BME, SI, F

Main products/instrumentation under R&D: Air pumps, infusion-withdrawal pumps.

2904

WAVE BIOTECH, LLC.

E-mail: [email protected]

Add: 2493 Lamington Rd. Bedminister, NJ 07921

Web site: www.watlow.com

Tel: (908) 781-5757

President/CEO: Gary Neal

Fax: (908) 781-5767

Research director: Lou Steinhauser

President: Vijay Singh, Ph.D.

R&D expertise: R&D and manufacture of industrial heaters, sensors, controllers, etc.

Research director: Vijay Singh, Ph.D.

Technological expertise: BME, AMS, COC Main products/instrumentation under R&D: Contract manufacturing products, contract research/clinical trial product, thermal management systems for cell incubation, industrial heaters, sensor, control DNA analysis, other instrumentation/laboratory applications.

2903

WATSON-MARLOW/BREDEL PUMPS

R&D expertise: Development and manufacture of special purpose instrumentation for biopharmaceuticals research of drug and laboratory equipment. Technological expertise: F, C/TC, PMC, BA, GT Principal products/instrumentation: Biologicals, vaccines, monoclonal antibodies; Wave Bioreactor (disposable cell culture devices from 100 mL to 100 liters), ReeWelder Sterile Tube Fuser (for large bore tubing), Wave Mixer (sterile disposable solution prep), Thermo Tag (miniature digital temperature loggers).

Add: 37 Upton Technology Park, Wilmington, MA 01887-1018

Main products/instrumentation under R&D: Wave agitation devices.

Tel: (800) 282-8823

Subsidiary bodies: Manufacturing facility in Switzerland.

Fax: (978) 658-0041

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Sealed and granted patents: WaveBioreactor/ Wave agitation.

2905

W. B. MOORE, INC.

Add: P.O, Box 1936 900 Line St., Bay 11 Easton, PA 18044

2907

WEDGEWOOD TECHNOLOGY, INC.

Add: 300 Industrial Road San Carlos, CA 94070-2601 Tel: (650) 593-1598 Fax: (650) 593-0235

Tel: (610) 559-9474

President/CEO: Lori Wynn

Fax: (610) 559-1546

Research director: William H. Wynn

President: W. Burns Moore

R&D expertise: Bioprocess engineering research, manufacture of process scale biopharm monitors for UV, pH, conductivity/temperature, pressure, solids, color and turbidity.

R&D expertise: Development, manufacture and marketing of special products for biotechnology research. Technological expertise: BA, PMC, F Principal products/instrumentation: Full line of bioreactor and related items; filters and valves. Main products/instrumentation under R&D: Bios, bioreactor systems, biological filter.

2906

WEBBER MFG. CO., INC.

Add: 8498 Brookviile Road POB 19449 Indianapolis, IN 46239 Tel: (317) 357-8681 Fax: (317) 357-8695 E-mail: [email protected]

Technological expertise: F, LP, P/S, BA, PMC Principal products/instrumentation: Model 600 pH; Model 680 NIR analyzer; Model 700; Model 622 Conductivity; Model 722 conductivity, Model 681 Color; Model 662 UV Analyzer; Model 762 UV Analyzer; Model 652 cell growth probe; Model 612 Photometer, Biostation; Model 670 Turbidity monitor. Main products/instrumentation under R&D: Process scale biopharm monitors.

2908

WESTBRIDGE AGRICULTURAL PRODUCTS

Add: 1150 Joshua Way Vista, CA 92083 Tel: (800) 876-2767

President/CEO: David E. Lovett

Fax: (760) 599-6965

R&D expertise: Development and production and marketing of automation systems, industrial freezers, environmental test chambers, thermal shock, etc.

E-mail: [email protected]

Technological expertise: CH/S, PMC, R, AU

Research director: Lawrence Parker, Ph.D.

Principal products/instrumentation: Automaton system, laboratory/industrial freezers, environmental test chamber, contract manufacturing products.

Web site: www.westbridge.com President: Tina Koenemann R&D expertise: R&D and production of biotechnology and agricultural products; seed culture research, seed engineering development. Technological expertise: G, C/TC

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Principal products/instrumentation: Agriculture, biologicals, bioremediation, natural products, pesticides, toxic waste processing, TRIGGER, Sunburst, Biolink.

2909

WESTFALIA SEPARATOR AUSTRALIA PTY, LTD.

911

Subsidiary bodies: GEA PT Canada, Inc., 5353 John Lucas Dr., Burlington, ON L7L 6G5, Tel: (905) 319-3900; West, 19530 Cabot Blvd, Hayward, CA, Tel: (510) 259-1100; Southwest, 2408 Timberloch Place, The Woodlands, TX, Tel: (281) 362-1000; Midwest, 725 Tollgate Rd., Elgin, IL, 60123, Tel: (708) 7420800; South, 360 Sixth St S.W., Winter Haven, FL, 33880, Tel: (813) 299-3900.

Add: P.O. Box 398 Tullamarine Melbourne, Victoria 3043 Australia Tel: (61) 3-9335-1533

2911

WEYERHAEUSER CO.

Fax: (61) 3-9335-1515

Add: Tacoma, WA 98477

Research director: Rob Donahue

Tel: (206) 924-2345

Subsidiary of Westfalia Separator AG.

Fax: (206) 924-2685

R&D expertise: Design and manufacture of separators, decanters, and centrifuges.

President/CEO: Steven R. Rogel

Principal products/instrumentation: Contract R&D products. Main products/instrumentation under R&D: Separators, decanters, centrifuges.

2910

WESTFALIA SEPARATOR, INC.

Add: 100 Fairway Ct. Northvale, NJ 07647 Tel: (201) 767-3900 Fax: (201) 767-3416 E-mail: [email protected] Web site: www.wsus.com President: Hanno Lehmann R&D expertise: Biotechnology medicines and bioprocess engineering research, novel products development. Technological expertise: PIS, F, E, C/TC, BA, P/S, LP Principal products/instrumentation: Biologicals, enzymes, antibiotics, reagents, peptides, vaccines, specialty chemicals, monoclonal antibodies. Westfalia™ centrifugal separators, homogenizers and mixers.

R&D expertise: R&D and manufacture of forest biotechnology products; plant tissue culture; seed culture artificial Technology; environmental analysis; waste treatment; related products development. R&D collaboration: Biopulping Consortium (USDA and University of Wisconsin) — lignin degrading fungi; Plant Genetics, Inc. — artificial seed, embryogenesis; Chiron Corp. — cellulose. Key license and trade contracts: Plant Genetics, Inc. — Gel-Coat™ Technological expertise: BI, G. Principal products/instrumentation: Genetically improved seeds, specialty chemicals. Main products/instrumentation under R&D: Forest biotechnology products, plant tissue culture, artificial seed culture technology.

2912

WHATMAN HEALTHCARE

Add: 461 W. Morgan Road Ann Arbor, MI 48103 Tel: (734) 665-3300 Fax: (734) 822-0030

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E-mail: [email protected] Web site: www.whatman.com CEO: David Smith R&D expertise: Development and production of filter devices, diagnostics, medical media and biochrom. Technological expertise: P/S, BME Principal products/instrumentation: Contract R&D products. Main products/instrumentation under R&D: Filter devices for drug research, medical media, biochrom.

Subsidiary bodies: Ann Arbor, MI; Rockland, MA; Haverhill, MA; Maidstone, England; Banbury, England, Scarborough, Maine. Sealed and granted patents: 96 Well Filter Bottom Microplates.

2914

WHATMAN INTERNATIONAL, LTD.

Add: Whatman House St. Leonard’s Rd. Maidstone, Kent ME16 OLS U.K. Tel: (44) 162-267-6670 Fax: (44) 162-267-7011

2913

WHATMAN, INC.

E-mail: [email protected] President: Andrew Smithers

Add: 9 Bridewell Place Clifton, NJ 070141725

Research director: Dr. Peter Levison

Tel: (800) 441-6555

R&D expertise: Separation technology research, related novel products development.

Fax: (973) 472-6949

Technological expertise: P/S, HTDS, COC

E-mail: [email protected]

Principal products/instrumentation: Express Ion™ Ion exchange cellulose media, multiwell plates for high through screening and combinatorial chemistry, filtermedia and membranes.

Web site: www.whatman.com President/CEO: Dr. David Smith Research director: Dr. James Davis Subsidiary of Whatman PLC Ltd. R&D expertise: Research of filtration and separation technologies, related applied products manufacture. Technological expertise: BA, C/TC, COC, HTDS, P/S, G, GT Principal products/instrumentation: Syringe filters, tissue culture inserts, filtration devices, Express Ion™, Ionexchanger, Bonded silica ODS-3, ODS-4, glass fiber and cellulose filter paper, nitrocellulose membranes, Cyclopore™ track etched membrane, Anopore™ alumina membrane, encapsulated filters and specialty 96 and 384 well microplates, nuclepore, tracketched membrane. Main products/instrumentation under R&D: 96 well filter bottom microplates.

Main products/instrumentation under R&D: Separation and purification technologies, separation gel. Subsidiary bodies: Whatman s.a., LouvainlaNeuve, Belgium; Whatman sarl, Villeneuve d’Aseq, Cedex, France; Whatman Holdings GmbH, Bad Soden/T, Germany; Whatman Faltrak.Filtertechriik-Vertriebsgeselischaft GmbH I.G., Harmmerunterwiesenthal, Germany, Biometra GmbH, Gottingen, Germany; Gerbermembrane GmbH, Gerbershausen, Germany; WexFilertechnikGmbH, Rotenburg A.D. Fulda, Germany; Whatman, Inc., Lexington, Mass, U.S.A.; Haverhill, Mass, U.S.A.; Shrewsbury, Mass, U.S.A.; Clifton, NJ, U.S.A.; Fairfield, NJ, U.S.A.; Cleveland, OH, U.S.A.; Whatman Labscales, Inc. Hillsboro, Or,

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U.S.A.; Arbor Technologies, Inc., Ann Arbor, MI, U.S.A.; Biometra, Inc., Tampa, FL, U.S.A.

2915

WHATMAN POLYFILTRONICS

Add: 136 Weymouth St. Rockland, MA 02370-1147 Tel: (781) 753-6214 Fax: (781) 878-0822 E-mail: [email protected] Web site: www.whatman.com

913

R&D expertise: Manufacture and marketing of special products for laboratories — glassware, plastic ware and instrumentation. Key sales market contracts: B. Braun Biotech, Socorex. Technological expertise: F, P/S, BA, C/TC, BME Principal products/instrumentation: E-Z Vials™, V-Vials™, Wheaton Media Squares™, Serum Bottles. Main products/instrumentation under R&D: Glasswares, glass pipets, plastic ware.

CEO: Dr. D. J. H. Smith Research director: Dr. Martin Smith

2917

Subsidiary of Whatman PLC. R&D expertise: Development and production of diagnostic and therapeutic disposables. Technological expertise: P/S, C/TC, R, X Principal products/instrumentation: Diagnostics, UNIFILTER, UNIPLATE®, MultiChem™, Viewplate™.

WHITE EAGLE TOXICOLOGY LABORATORIES

Add: 2003 Lower State Rd. Doylestown, PA 18901 Tel: (215) 348-3868 Fax: (215) 348-5081 E-mail: [email protected]

Main products/instrumentation under R&D: Multi-well filter, microplates.

President/CEO: Abbott S. Dver, VMD

Subsidiary bodies: Germany, England, Japan, Singapore.

R&D expertise: Safety evaluation contract research of pharmaceuticals, biologicals, specialty chemicals and surgical devices, etc.

Sealed and granted patents: Multi-well filters, microplates, OTC tests.

2916

WHEATON SCIENCE PRODUCTS DIV.

Add: 1501 10th St. Millville, NJ 08332

Research director: C. Steven Godin, Ph.D.

Technological expertise: CS, CBPG, BME, COC Principal products/instrumentation: Contract R&D products. Main products/instrumentation under R&D: Safety evaluation of pharmaceuticals, specialty chemicals.

Tel: (609) 825-1100 Fax: (609) 825-1368 E-mail: [email protected]

2918

WIEN LABORATORIES, INC.

Web site: www.wheaton.com

Add: P.O. Box 227 Succasunna, NJ 07876

President: S. Drozdow

Tel: (973) 584-7019

Research director: Ken Carll

Fax: (973) 584-0210

Subsidiary of A-L Holding, Inc.

E-mail: [email protected]

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Web site: www.researchD.com

Tel: (419) 289-8700

President: Bret G. Wien

Fax: (419) 289-3650.

R&D expertise: Design, development and sale of in vitro diagnostic kits for use in mainstream clinical market and esoteric R&D market

President/CEO: Joseph F. Holson, Ph.D.

Key sales market contracts: Radim (Belgium) kits and reagents. Technological expertise: RD, P/S, SY, DD, AB Principal products/instrumentation: Steroid antisera and other specialty antibodies. Main products/instrumentation under R&D: Esoteric drugs, in vitro diagnostic kits.

2919

Research director: Chris Chengelis, Ph.D. Subsidiary of Great Lakes Chemical Corp. R&D expertise: Contract research; toxicological testing, novel drug products development. Technological expertise: BME Principal products/instrumentation: Veterinary medical consumer products. Main products/instrumentation under R&D: Toxicity test, toxicosozin, Safety pharmacology-telemetry, Bone densitometry, LCMS/MS

WILHELM WERNER GMBH

Add: Maybachstrasse 29 Leverkusen, NRW 51381 Germany

2921

WISCONSIN OVEN DISTRIBUTORS, INC.

Tel: (49) 217-176-750

Add: 2675 Main St. East Troy, WI 53120

Fax: (49) 217-176-7510

Tel: (414) 642-3938

E-mail: [email protected]

Fax: (414) 363-4018

President: Hans Ulrich Trager

R&D expertise: Development and supply of biomedical laboratory equipment/instrumentation, laboratory ovens, water baths and general purpose and CO2, incubators manufactured by Memmert GmbH & Co., Germany.

Research director: Andreas Zupp R&D expertise: Development and production of ultrapure water systems. R&D collaboration: KFA Forschungszentrum Jueclich Technological expertise: F, P/S, BA Principal products/instrumentation: Vaccines, reagents, diagnostics, cosmetics, RNA and DNA-free ultrapure water. Main products/instrumentation under R&D: Ultrapure water systems, microelectronics water. Sealed and granted patents: Microelectronics water.

Technological expertise: AF, AB, BI, BA, BS, CB, C/TC, COC, CC, RD, Q, SMC, SY, TE, T, GA, GT, G, HTDS, H/CF, PIS, PG, PMC, P/S, R Principal products/instrumentation: Laboratory ovens, incubators. Main products/instrumentation under R&D: Biomedical laboratory other equipment/ instruments.

2922 2920

WIL RESEARCH LABORATORIES, INC.

Add: 1407 George Rd. Ashland, OH 44805

WOODS END RESEARCH LABORATORIES, INC.

Add: 290 Belgrade Road, P.O. Box 297, Mt Vernon, ME 04352

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Tel: (207) 293-2457 Fax: (207) 293-2488

2924

915

WORTHINGTON BIOCHEMICAL CORP.

E-mail: [email protected] Web site: www.woodsend.org

Add: 730 Vassar Ave. Lakewood, NJ 08701

President: William F. Brinton

Tel: (732) 942-1660

Research director: Eric Evans

Fax: (732) 942-9270

R&D expertise: Research of environmental biodegradation, related products development.

E-mail: [email protected]

Key license and trade contracts: Stone Container, Inc., biodegradeable bags.

Research director: Patricia Thompson

Technological expertise: F, E, PMC Principal products/instrumentation: Compost Futures® for composting technology, Compost Happens® for composting consultants. Main products/instrumentation under R&D: Diagnostics kits for solid waste biotransformations, environmental pollutant biodegradation pathway.

2923

WORLD PRECISION INSTRUMENTS, INC.

Add: 175 Sarasota Center Blvd. Sarasota, FL 34240-9258 Tel: (941) 371-1003 Fax: (941) 377-5428 E-mail: [email protected] Web site: www.wpiinc.com President: Harry Fein R&D expertise: Manufacture of lab equipment used in intracellular research — amplifiers, stimulators, electrometers, systems for tissue research, microscopes, spectrophotometry and gas detectors. Technological expertise: C/TC, CH/S Principal products/instrumentation: Biopharmaceuticals, veterinary products, instruments for intracellular research, specialty chemicals, contract R&D products.

Web site: www.worthington-biochem.com President: Von Worthington R&D expertise: Research, development and manufacture of bulk clinical enzymes; enzymes and biochemicals for life science research. Technological expertise: F, E, LP, BA, RD, P/S, C/TC, ET, ERT Principal products/instrumentation: Tissue dissociation enzymes, proteases, molecular biology products, diagnostic reagent component enzymes, purified proteins, nucleic acids, plasmids, vectors, related biochemicals and kits for cell isolation, tissue dissociation and culture; enzymes, include collagenases, trypsins, hyaluronidases, elastases and papain; contract fermentation and purification. Hepatocyte Isolation System: developed to provide researchers with a reliable, convenient, and consistent hepatocyte cell-isolation system. By using the pre-optimized combination of enzymes contained in this kit, it is possible to minimize the lot-to-lot variation and improve the quality of the isolated hepatocytes. Each kit includes single-use enzyme vials, balanced salt solution, buffer, culture media, and an optimized protocol for five separate adult rat liver perfusions. A modified protocol for mouse applications is also available, 2009; Hepatocyte Isolation System: The System has been developed to provide researchers with a reliable, convenient, and consistent hepatocyte cell-isolation system, 2009. Main products/instrumentation under R&D: Bulk clinical enzymes, biochemicals for life

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science research. Lead drug MOR 103, a full human HuCAL-derived monoclonal antibody directed against granulocyte macrophage-colonystimulating factor, for the treatment of active rheumatoid arthritis (RA), Phase Ib/IIa, 2009.

2925

WUHAN CHINESE MOXIBUSTION TECHNOLOGY DEVELOPMENT CO., LTD.

Add: No. 1 Mao Shan Da Dao, Jian Xia District, Wu Han 430223, P. R. China Tel: (86) 27-8899-0340 Fax: (86) 27-8799-0336

Tel: (86) 27-8422-2322 Fax: (86) 27-8422-2259 E-mail: [email protected] Web site: www.whtjxd.com R&D expertise: R&D of Traditional Chinese Medicine, and practical new products manufacture. Technological expertise: TCMM, HNT Principal products/instrumentation: Golden prize products with national patent — BianNai Tong Tea; National type II new drug — Acketing; high-content calcium supplement — Guilide; “the Chinese initiated and world leading new drug”—insulin oral spray, etc.

Web site: www.zhongguojiu.cn/produce_xx.asp R&D expertise: R&D of Chinese moxibustion medicine series, related novel products manufacture. Technological expertise: HNT, CMM Principal products/instrumentation: Chinese moxibustion, the first series of Chinese moxibustion with decades of varieties had all entered into the market in 2008. Characteristics of this medicinal moxibustion include taking fast effect for combining medicinal therapy and physical therapy, and treating the internal pain from external without toxic side effect. Main products/instrumentation under R&D: In the future years, the indications on sixty varieties in five series of Chinese moxibustion for department of internal medicine, department of external medicine, department of gynaecology, department of pediatrics, department of eye and other departments will be promoted into the market in succession.

2926

2927

WYATT TECHNOLOGY CORP.

Add: 6300 Hollister Ave. Santa Barbara, CA 93117-3253 Tel: (805) 681-9009 Fax: (805) 681-0123 E-mail: [email protected] Web site: www.wyatt.com President: Philip J. Wyatt R&D expertise: Design and manufacture of analytical instruments for absolute macromolecular characterization. Technological expertise: BME, SI, RPP, P/PS Principal products/instrumentation: Dawn Photometer, Optilab RI Detector, Minidawn Detector, High temperature mini DAWN, Calypso, an automated protein association and aggregation system, 2007. Main products/instrumentation under R&D: Analytical instruments for absolute macromolecular characterization.

WUHAN TONGJI PHARMACEUTICAL CO., LTD. 2928

Add: No. 22 High-tech Industrial Park, Economic and Technological Development Zone, Wu Han, China.

WYDEN RESEARCH

Add: 26 West 9 Street New York, NY 100118924

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Tel: (212) 228-8749 Fax: (212) 228-8749 E-mail: [email protected] President: Stephen Wyden R&D expertise: R&D of biotech with focus on agricultural products-basic and applied reproduction technologies and applications.

917

system, Phase I; DNA and RNA purification kits, PCR related kits. Sealed and granted patents: Mega base cloning system (pending).

2930

XANTHON, INC.

Technological expertise: BI, BA, C/TC, CH/SGT, G, F, TE, T, H/CF

Add: P.O. Box 12296 104 Alexander Drive Bldg. 21 Research Triangle Park, NC 27709

Main products/instrumentation under R&D: Reproduction technologies and applications methods, agriculture pesticide agrobacteriocin.

Tel: (919) 572-0707 Fax: (919) 547-3723 E-mail: [email protected] President/CEO: James D. Skinner

2929

WYO BIGEN

Add: 1948 Howe Rd. Laramie, WY 82070 Tel: (307) 766-6380 Fax: (307) 766-5098 E-mail: [email protected] President: Randolph V, Lewis Research director: Yoichi Kadokami R&D expertise: Research of biotechnologies, and related applied drug products development. Joint ventures: Amresco, Inc., DNA and RNA purification kits; Toyobo, Inc., PCR related kits. Key sales market contracts: Amresco, Inc.; Toyabo, Inc. Key license and trade contracts: Amresco, Inc.; Toyabo, Inc. Technological expertise: Q, GA, P/S, RD Principal products/instrumentation: Screen Max plasmid mini-prep test (JT Baker); Rapid RNA purification kit; PCR. system; Gene Sweep; Plasmid Fast; rapid mRNA purification kit; rapid genomic DNA purification kit. Main products/instrumentation under R&D: Megabase cloning system, Phase II; RNA sequencing kit, Phase II; RNA subtraction kit, Phase II; gradient field gel electrophoresis

Research director: Carole Golden R&D expertise: Biotech drugs R&D and equipments production. R&D collaboration: SRA Duke University, SRA University of North Carolina at Chapel Hill, SRA North Carolina State University; SRA Brown University. Key license and trade contracts: University of North Carolina at Chapel Hill. Technological expertise: G, HTDS Main products/instrumentation under R&D: Xanthon Expression Analysis System Release Ql, novel biotech drugs.

2931

XCYTE THERAPIES, INC.

Add: 1124 Columbia, Ste. 130 Seattle, WA 98104 Tel: (206) 262-6200 Fax: (206) 262-0900 President/CEO: Ron Berenson, M.D. R&D expertise: R&D and manufacture of ex vivo T-cell therapeutic products in oncology and infectious diseases. Main products/instrumentation under R&D: Depsipeptide and congeners, ex vivo T-cell

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expansion for oncology and infectious diseases, Xcellerate, Phase I.

R&D collaboration: OSI Pharmaceuticals, Inc.

Sealed and granted patents: Several pending; simultaneous stimulation and concentration of cells. 6,905,874, U.S.; Depsipeptide and congeners thereof for use as immunosuppressants. 6,403,555, U.S.

Key license and trade contracts: Aurora Biosciences Corp., Cerep S.A., Affymetrix, Gene Logic, Rosetta Inpharmatics, Incyte Pharmaceuticals, SmithKline Beechman, Genzyme Corp., Genetrace Systems and Motorola.

2932

XECHEM, INC.

Add: 100 Jersey Ave., Bldg. B, Suite 310 New Brunswick, NJ 08901 Tel: (732) 247-3300 Fax: (732) 247-4090 E-mail: [email protected] President/CEO: Ramesh C. Pandey, Ph.D. Research director: Luben Yankov R&D expertise: R&D and manufacture of biopharmaceutical products. Technological expertise: CC, F, LP, AF, BA, C/TC, P/S, SY Principal products/instrumentation: Specialty chemicals, natural products, antibiotics, enzyme, Paclitaxel and Nutraceuticals (GinkgoOnce, GinsengOnce, GarlicOnce, Gugulon); Bleomycin, Lovastatin. Main products/instrumentation under R&D: Biopharmaceutical products.

Technological expertise: C/TC, HTDS, RD, BI, G Principal products/instrumentation: In vitro test systems for safety and efficiency in drug development. Gene profile assays, genetic toxicology assays, both automated. Main products/instrumentation under R&D: High throughput cell-based screens, drug development technologies, gene profiling technologies. Sealed and granted patents: Gene profiling technologies/Ames II.

2934

XENOPORE CORP.

Add: 299 Wagaraw Rd. Hawthorne, NJ 07506 Tel: (973) 423-2400 Fax: (973) 423-2401 E-Mail: [email protected] President: Allan S. Douglas, Sc.D. Research director: Allan S. Douglas, Sc.D.

2933

XENOMETRIX, INC.

Add: 2425 N. 55th St., Ste. 1ll Boulder, CO 80301-5700 Tel: (303) 447-1773 Fax: (303) 447-1758 E-mail: [email protected] President: Pauline Gee Research director: Pauline Gee R&D expertise: Research of drug development technologies, novel drug products development and manufacture.

R&D expertise: R&D and production of specialty microarray and technic services. Key sales market contracts: Pierce Chemiz Technological expertise: PA, RD, CB, GA, HTDS, P/S Principal products/instrumentation: Xenobind™ microwell plates, Rapidflo™ dialysis membranes, Xenobeads™, Elona™ assay kit, Xenoprobe™ microwellplates, Xenobind™ white microwell plates, Xenobind™ black miaowell plates, Xenoprobe™ white microwell plates, Xenoprobe™ black microwell plates, Nickel Chelate microwell plates, Covalent

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binding plastic microscope slides, carbohydrate binding plate, surface modified polycarbonate plates; malcimide, glutethione, epoxy, lectins, protein A, protein G, coated glass microscope slides and cover slips; marval microarray printer. Main products/instrumentation under R&D: Specialty microarray.

919

Tel: (44) 753 706 600 Fax: (44) 753 706 607 CEO: David A Oxlade Research director: John Waterfall, Ph.D. R&D expertise: Discovery, design, development and commercialization of small molecule pharmaceutical using natural chemicals. R&D collaboration: Wamer-Lambert, Cancer Research Campaign, Zeneca.

2935

XENOS BIORESOURCES, INC.

Key sales market contracts: Warner-Lambert

Add: 351 Hitchcock Way B170 Santa Barbara, CA 93105

Technological expertise: RD, P/S, D-D, SMC, CS

Tel: (805) 563-4300

Main products/instrumentation under R&D: Small molecule immune-inflammatory disease drugs discovery/preclinical; XR5000 (novel anticancer agent), Phase II clinical; small molecule anti-cancer drugs (e.g., growth factor antagonists, inhibitors of intracellular signalling events and multi-drug resistance), discovery/ preclinical; small molecule plasminogen activator inhibitor (PAI) antagonist, discovery/ preclinical; p-gp inhibitors XR9576, in Phase II clinical trials; small molecule pharmaceuticals from natural chemicals.

Fax: (805) 563-2211 E-mail: [email protected] President: Diane W. Wolf R&D expertise: R&D and manufacture of pharmaceutical, veterinary drug and biotechnology medicines. Joint ventures: Exclusive distributor for Syntex, SA. Key sales market contracts: Exclusive distributor for Syntex, SA Technological expertise: CB, COC, COS Principal products/instrumentation: Secretin, somatotropin, trypsin, transferrin, fetuin, animal hormones, cholic acid, deoxycholic acid, thrombin, hemin, bilirubin, gags, Heparin, carbohydrates, growth factors, pharmaceutical intermediate, chondrotins, chondrotin sulfate, glycosoaminoglycans (GAGS), antibiotics, hyaluronic acid. Main products/instrumentation under R&D: Conjugated estrogens and low molecular weight chondrotin.

2936

XENOVA, LTD.

Add: 240 Bath Rd. Slough, Berkshire SL1 4EF U.K.

2937

XERION PHARMACEUTICALS

Add: Fraunhoferstr. 9 Martinsried D-82152 Germany Tel: (49) 898-999-640 Fax: (49) 898-999-6410 Web site: www.xerion-pharma.com President/CEO: Dr. Liming Ge Research director: Dr. Leodevico Iiag R&D expertise: Contract R&D of target validation, novel products manufacture. R&D collaboration: Strategic alliance with Protana A/S Technological expertise: PA, RD, R, Q, C/TC, PIS, CH/S, D-D, BI, P/S

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Main products/instrumentation under R&D: Protein knock-out technology platform, target validation. Targeted delivery of drugs. Sealed and granted patents: Three patents pending.

2938

XOMA, LTD.

Add: 2910 Seventh St. Berkeley, CA 94710 Tel: (510) 204-7200 Fax: (510) 649-0315 E-mail: [email protected] Web site: www.xoma.com

recombinant protein and antibody-derived biopharmaceuticals; Anti-CDlla treat psoriasis Phase III; kidney transplant Phase I/II; Mycoprex (anti-fungal): pre-IND; ING-l Mab (cancer): pre-IND; rBPI-derived anti-aniogenics: preclinical (ophthalmic, cancer); Genimune (gelonin fusion protein): preclinical; (autoimmune, T&B cell cancers). Subsidiary bodies: Xoma Santa Monica, 1545 17th St., Santa Monica, CA Sealed and granted patents: 50 issued for BPI, over 15 for others: LBP, MAb’s, cell expression; 7 notices of allowance; 20 pending.

CEO: John L. Castello Research director: Patrick J. Scannon, M.D., Ph.D. R&D expertise: R&D and manufacture of recombinant protein and antibody-derived biopharmaceuticals for infectious diseases, immunologic and inflammatory disorders, and cancer. BPI (bacterial/permeability-increaseing protein), XOMA’s infectious disease product development platform. lead drugs: NEUPREX, Anti-CD lla, etc. R&D collaboration: Genentech, Baxter, Allergan. Key sales market contracts: Genentech, Baxter, Allergan. Key license and trade contracts: Bacterial cell expression technology: Affymax Research Institute, Cantab, Enzon, Inc., ICOS, Pasteur Merieux Serums & Vaccins; anti-CD20; Genentech, IDEC; T-Cell receptor technology; Connectics Corp., Incyte Pharm: BPI Patents, Genetech: Anti CD 11a Mab, Invitrogen rec protein expression system. Technological expertise: F, PA, AF, PIS, RD, P/S, AB, P/PS Main products/instrumentation under R&D: NEUPREX treat meningocacemia, Phase III/IV; rBPI for ophthalmic antiinfective, preclinical;

2939

XTL BIOPHARMACEUTICALS, LTD.

Add: Kiryat Weizmann P.O. Box 370 Rehovot 76100 Israel Tel: (972) 8-940-5134 Fax: (972) 8-940-5017 E-mail: [email protected] President/CEO: Martin Becker Research director: Shlomo Dagan R&D expertise: R&D and manufacture of biopharmaceuticals, fully human monoclonal antibodies to viral targets and oncology targeted drugs. Animal model development of drug screening for HBV and HCV. Technological expertise: AB, MAE, DK R&D collaboration: Weizmann Institute, TelAviv University. Principal products/instrumentation: MAb to HBV. Main products/instrumentation under R&D: MAb to HAV, HBV and HCV, fully human monoclonal antibodies, animal model of drug screening. Sealed and granted patents: 12 pending.

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2940

XYMOTECH BIOSYSTEMS, INC.

Add: 2348 Ch. Lucerne Rd. Suite 625 Mt. Royal, QC, H3R 2J8, Canada

2942

921

YES BIOTECH LABORATORIES, LTD.

Tel: (800) 663-1392

Add: 7035 Fir Tree Dr. Unit #23 Mississauga, Ontario L5S 1V6 Canada

Fax: (514) 738-8499

Tel: (905) 677-9221

E-mail: [email protected]

Fax: (905) 677-0023

Web site: www.xymotech.com

E-mail: [email protected]

President: Charles Carol

Web site: www.yesbiotech.com

R&D expertise: Design and manufacture of biotech reagents and equipment for life sciences and biotechnology research institutions use.

President/CEO: George Ye, Ph.D.

Technological expertise: CC, E, F, CB, C/TC, AF, SY, P, TE, RD, R, SMC, GA, GT, HTDS, H/CF Principal products/instrumentation: Transfer and immobilization membranes, receptor binding cell harvesters, physiological & veterinary instruments, biochemicals, enzymes, lipids, sphingolipids, fatty acids. Main products/instrumentation under R&D: Novel biotech reagents.

2941

XYTEX CORPORATION

Add: 1100 Emmett St. Augusta, GA 309045826 Tel: (706) 733-0130 Fax: (706) 736-9720 E-mail: [email protected] Web site: www.xytex.com President: Armand M. Karow R&D expertise: Research of human gametes and human medicine (reproduction/oncology), related products development. Technological expertise: GT, C/TC Main products/instrumentation under R&D: gametophyte, gametocyte, human gametes.

Research director: James J. Hong, Ph.D. R&D expertise: Cell and tissue culture research, research and development, manufacturing and marketing of immunochemicals in the fields of infectious disease, tumor markers and novel cytokines for diagnostic and therapeutic applications. Joint ventures: Winnerway Yes Biotech & Pharmaceutical Co., Ltd. R&D collaboration: Shanghai Institute of Cell Biology, Chinese Academy of Medical Sciences, Chinese Academy of Sciences, Dept of Microbiology — NYU Medical Center. Key sales market contracts: Several distributing agents worldwide. Technological expertise: PA, Q, RD, P/S, C/TC, GA, H/CF Principal products/instrumentation: Monoclonal and polyclonal Abs to novel cytokines, growth factors, tumor markers, infectious diseases, diagnostic kits, immunoassay systems, bioactive peptides, recombinant proteins, viral antigens and anti-cytokine therapy; treatment of psoriasis of other inflammatory skin conditions, ELISA kits Main products/instrumentation under R&D: Novel cytokine (chemokine) detection kits; chimeric neutralizing antibodies to novel chemokines and their receptors for clinical applications; anti-cytokine therapy.

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Subsidiary bodies: Joint venture pharmaceutical company in China. Sealed and granted patents: Anti-cytokine therapy.

2943

YES TECHNOLOGIES

immunogens, RT-DNA produced cytokines and growth factors, specialty biochemicals, peptide instruments. Main products/instrumentation under R&D: Antibodies to tumor markers, cardiac disease markers, fibrinolytic reagents, new RT-DNA growth factors, peptides and cytokines, immunological reagents for diagnostics.

Add: 320 S. Willson Ave. Bozeman, MT 59715 Tel: (406) 586-2002 Fax: (406) 586-8818

2945

YSI, INC.

President: Mary M. Hunter

Add: 1725 Brannum Lane Yellow Springs, OH 45387-1107

Research director: Robert M. Hunter

Tel: (937) 767-7241

R&D expertise: Research of drug novel products and development of biotechnology medicines.

Fax: (937) 767-9353

Technological expertise: BA, CH/S Main products/instrumentation under R&D: contract research/clinical trials products, cyanide-free biocatalyzed leaching of precious metals, Phase III/IV; Anaerobic bioremediation process, Phase III-Commerical Trail; anaerobic biooxidation Process, Phase I; anaeorbic respirometer, Phase II.

2944

YORK BIOLOGICALS

Add: 24 Old Wood Rd. Stony Brook, NY 11790 Tel: (516) 751-6553

E-mail: [email protected] Web site: www.ysi.com President/CEO: Malte Von Matthiessen Research director: Barbara McQuiston R&D expertise: Sensor development and manufacturing. Technological expertise: BA, F, C/TC, PMC Principal products/instrumentation: 2,700 select biochemistry analyzer, dissolved oxygen instruments, 8,500 PCO(2) monitor, analytical instrumentation. Main products/instrumentation under R&D: Various patented biosensor. Sealed and granted patents: Various biosensor patents.

Fax: (516) 751-6543 President: John J. DiSIena R&D expertise: immunological reagents development for diagnostics, R&D and manufacture of recombinant DNA-produced growth factors and cytokines. Technological expertise: F, P, PA, RD, P/S, BP, PI Principal products/instrumentation: Monoclonal antibodies, polyclonal antisera, antigens,

2946

YUNNAN BAIYAO (GROUP) CO., LTD.

Add: No. 222 Er Han Si Lu, Ku Ming City, Yun Nan 050118, P. R. China Tel: (86) 871-889-5599 Fax: (86) 871-832-6685 E-mail: [email protected] Web site: www.yunnanbaiyao.com.cn

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R&D expertise: R&D and manufacture of special TCMM.

Tel: (800) 233-2343

Expert in technologies: TCMM, HNT

E-mail: [email protected]

Principal products/instrumentation: Yunnan Baiyao, Yunnan Baiyao capsule, Gongxue Ning capsule, Yunnan Baiyan spray, Yunnan Baiyan tinctura, Xiaochaihu keli (granule), Redaqing pian (tablet), shengsan qi pian (tablet), shusan qi pian (tablet), Fufang nanban Langen Keli (granule), Yunnan Baiyao gao (plaster), Vehicular Yunnan Baiyao first aid kit. Yunnan Baiyao chuangketie, Yunnan Baiyao gao (ointment), san qi fen (powder), shengling Jianpiwei keli (granule), Tianmayen (powder), Tian Qi Huaye Keli (granule), etc.

2947

ZAXIS INTERNATIONAL, INC.

Add: 1890 Georgetown Rd. Hudson, OH 44236 Tel: (330) 650-2044

923

Fax: (914) 681-7446 Web site: www.zeiss.com/micro President: Jim Kelly R&D expertise: R&D and manufacture of microscopes and other instrumentation for R&D and QC laboratories, including image analysis and histology research. Technological expertise: BME Principal products/instrumentation: Research microscopes, Axioplan™; inverted microscopes, Axiovert™, 1999; stereo microscopes, Stemi 2000 SV 11 APO; confocal laser scamming microscopes; LSM 5 Pascal, AxioPlan 2, Imaging Axicam Digital Camera. Main products/instrumentation under R&D: Microscopes for image analysis and histology research.

Fax: (330) 650-2024 President/CEO: John Hrobsky Research director: Gregory S. Bambeck, Ph.D.

2949

ZENECA LIFESCIENCE MOLECULES

R&D expertise: R&D and manufacture of precast polyacrylamide electrophoresis gels and reagents.

Add: P.O. Box 2 Belasis Avenue, Billingham Cleveland TS23 1YN U.K.

Technological expertise: Q, COC, G, PG, P/S

Tel: (44) 164-236-4567

Principal products/instrumentation: Contract manufacturing reagents, lipo protein fractionation system, (LFS), Precast DNA sequencing gels, Precast Protein seperation gels; reagents.

Fax: (44) 164-236-4463

Main products/instrumentation under R&D: Precast polyacrylamide electrophoresis gels, novel lipoprotein fractionation system.

Research director: David Byrom

Sealed and granted patents: Lipoprotein Fractionation System 1996.

2948

CEO: Stephen Taylor Subsidiary of Zeneca Ltd R&D expertise: Supply of process development and manufacturing solutions to the human healthcare and lifescience industries. Technological expertise: CC, E, F, SMC, BA, PIS, P/S, RD

ZEISS, CARL, INC.

Add: Microscopy Division Dr. Thornwood, NY 10594

E-mail: [email protected]

One

Zeiss

Principal products/instrumentation: Contract manufacturing products, contract research/ clinical trial products.

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Main products/instrumentation under R&D: Human healthcare drugs.

2950

ZENECA MOGEN

Add: P.O. Box 628 Leiden 2300 AP The Netherlands Tel: (71) 525-8282 Fax: (71) 522-1471 President: Dr. Leo S. Melchers Research director: Dr. Leo Melchers

Main products/instrumentation under R&D: Drug delivery systems

2952

ZEPTOMETRIX CORPORATION

Add: 872 Main St. Buffalo, NY 14202 Tel: (716) 882-0920 Fax: (716) 882-0920 E-mail: [email protected] President: James C. D. Hengst, Ph.D.

Subsidiary of Zeneca Ltd., U.K.

Research director: James C. D. Hengst., Ph.D.

R&D expertise: Applied research & development of genetically engineered crops; license technology in agriculture, horticulture & floriculture.

R&D expertise: R&D and manufacture of human retroviral diagnostics, cytokines, mouse monoclonals and purified viruses; contract drug products manufacturing item.

Joint ventures: PlantZyme (JV with GistBrocades).

Technological expertise: C/TC, P/S, GA, H/CF, MAE

Technological expertise: T, AF, RD, C/TC

Principal products/instrumentation: Human retroviral diagnostics, including antigen ELISAs for HIV p24, SIV p27 and HTLV I/II p19. Enzyme linked oligonucleotide assays, monoclonals for HIV and HTLV 1 and II, cytokines and growth factors; purified viruses. ELISAs for hybridoma screening and quantation of human and mouse IgG and IgM. Products to detect reactive oxygen species, including TBARs assay. Support reagents for researchers.

Principal products/instrumentation: Binary vector system. Main products/instrumentation under R&D: F.R., field testing; N.R., lab; V.R., field testing; enzymes in plants, field testing; trehalose in plants. Sealed and granted patents: BVS.

2951

ZENTRX, INC.

Add: 183 Calle Magdalena, Suite 101 Encinitas, CA 92024 Tel: (760) 632-4880 Fax: (760) 632-4888

Main products/instrumentation under R&D: Purified viruses as raw materials for diagnostic and vaccine manufacturers, mouse monoclonals, assays for detecting and quantitating reactive oxygen species. DNA purification products.

President/CEO: David E. Morgan R&D expertise: R&D and manufacture/marketing of pharmaceutical and drug delivery systems. Technological expertise: DD Principal products/instrumentation: Biologicals, contract research/clinical trials products, nutraceuticals.

2953

ZEPTOSENS AG

Add: Benkenstrasse 254, 4108 Witterswil, Switzerland Tel: (41) 61-726-8181 Fax: (41) 61-726-8171

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E-mail: [email protected]

President: Dr. Avi Zer

Web site: www.zeptosens.com

Research director: Mr. Roni Zer

CEO: Markus Ehrat

R&D expertise: Development and manufacture of clinical diagnostic/assays products for disease.

Research director: Markus Ehrat R&D collaboration: Qiagen GmbH, Hiden, Germany. R&D expertise: Development and manufacture of clinical diagnostic/assays products for diseases. Technological expertise: PA, E, F, GA Principal products/instrumentation: Biosensors, thinfilm planar wave guide technology, instruments for pharmaceutical research. Main products/instrumentation under R&D: Biochips and corresponding chip reader systems.

Technological expertise: PA, E, F, GA Principal products/instrumentation: Pregnancy tests (after 10)™; ovulation tests; CIA immunoassay (One-Line™); FSH (Menopause); drugs of abuse, HIV one step; malaria one step; syphilis troponin one step; H. pylori, alcohol, hepatitis, Strep A, Strep B, lit plus lemme.

2956

Sealed and granted patents: Thin film planar wave guide technology.

ZER SCIENCE BASED INDUSTRIES, LTD.

Add: 34 Ben Yehuda St. Jerusalem 91039 Israel 2954

ZERAIM GEDERA, LTD.

Tel: (972) 2-522-462 Fax: (972) 2-512-898

Add: P.O. Box 103, Gedera 70750 Israel Tel: (972) 8-594-605 Fax: (972) 8-594-376 R&D expertise: Cultivation, production and marketing of seeds for vegetables and field crops. Technological expertise: C/TC, T, TE Principal products/instrumentation: seeds of ameliorative vegetables and crops. Main products/instrumentation under R&D: Vegetable seeds, cultivation.

2955

ZER HITECH (1976), LTD.

R&D expertise: R&D of in vitro diagnostic assays for pregnancy, ovulation, menopause, hepatitis, AIDS, AND sensitive tests for antisperm antibodies and TSH deficiencies. Technological expertise: AB, C/TC, BS Principal products/instrumentation: Antisperm antibodies therapeutic drug for AIDS and hepatitis. Main products/instrumentation under R&D: In vitro diagnostic assays for pregnancy, ovulation, menopause, etc.

2957

ZEUS SCIENTIFIC, INC.

Add: Shatner 3, Givat Shaul Jerusalem 95461 Israel

Add: P.O. Box 38 Raritan, NJ 08869-0038

Tel: (972) 2-652-2462

Fax: (908) 526-2058

Fax: (972) 2-651-2898

Web site: www.zeusscientific.com

E-mail: [email protected]

President: Scott J. Tourville

Tel: (908) 526-3744

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Research director: Mark Kopnitsky R&D expertise: R&D of in vitro diagnostic kits and assays for clinical laboratories; related products manufacture. Technological expertise: BME, C/TC Principal products/instrumentation: Autoimmune, bacterial, parasitic and viral IFA & ELISA serological assays.

2958

ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD.

(tablet), Niuhuang Jiedu pian (tablet), Fufang Pien tze huang ganbo, pien tze huang runhou pian (tablet), etc.

2959

ZHEJIANG ZHENYUAN PHARMACEUTICAL CO., LTD.

Add: 1015 West Shengli Rd. Shaoxing, Zhejiang 312000, P. R. China Tel: (86) 575-8515-8965 Fax: (86) 575-8515-3789 E-mail: [email protected] Web site: www.zypharm.com

Add: Shang Jie, Zhang Zhou City, Fujian, China, 350000

President: Mo Yanyin

Tel: (86) 596-230-5448

R&D expertise: R&D and novel products manufacture of antibiotics.

Fax: (86) 596-230-6435

Technological expertise: F, SY, CS, COC

E-mail: [email protected] Web site: www.zzpzh.com

Principal products/instrumentation: Nystatin, Spiramycin, Roxithromycin, Netilmicin.

R&D expertise: R&D and manufacture of TCMM.

Main products/instrumentation under R&D: Novel antibiotics.

Technological expertise: TCMM, HNT Principal products/instrumtntation: Xinshu bao pian (tablet) for relaxing oppressed feeling in chest, choking sensation in chest and palpitation, used in treatment of coronary heart disease and angina pectoris; Qingre zhike keli (granule) for removing heatphlegm, ventilating the lung and antitussive, used in treatment of exopathogenic wind-cold with productive cough and heat-phlegm; Yinda piangan capsule for purging intense heat, clearing toxin, relieving alcoholism and protecting livers; Jintangning capsule for treatment of typeII Diabetes mellitus, and also, pien tze huang, pien tze huang capsule, Fufang pien tze huang ointment, Chanbei Qingfei syrup, Huoxiang zhengqi shui capsule, xiaoyao wan (pill), Banlangen keli (granule), Liuwei Dihuang wan (pill), Qiju Dihuang wan (pill), Hugan pian (tablet), Zengru gao (ointment), Fufang Danshen pian

2960

ZINSSER ANALYTIC GMBH

Add: Eschborner Landstr. 135 Frankfurt D60489 Germany Tel: (49) 697-891-060 Fax: (49) 6978-910-680 President: W. Zinsser R&D expertise: R&D and manufacture/ marketing of biomedical instrumentation for drug research and novel product development. Technological expertise: COC, PIS, R, HTDS, SY Principal products/instrumentation: SOPHAS automatic synthesizer for parallel synthesis. Main products/instrumentation under R&D: Peptides, customs synthesis, instruments for drug research. Speedy 2002 Solid-phase Extract, 2007.

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2961

ZIRCHROM SEPARATIONS, INC.

Add: P.O. Box 868, 617 Pierce Street, Anoka, MN 55303 Tel: (763) 421-5264 Fax: (763) 421-2319 E-mail: [email protected] Web site: www.zirchrom.com President: Peter W. Carr Research director: Clayton V. McNeff R&D expertise: Development and manufacture of laboratory biomedical equipments. Technological expertise: P/S, BME Principal products/instrumentation: Chromatography products, Zirchrom®; biologicals, natural products, agricultural pesticide.

Tel: (972) 4-989-7234 Fax: (972) 4-989-7200 E-mail: [email protected] President: Akiva Polak Research director: Dr. Oded Vashitz R&D expertise: Development and production of detergents and biochemicals. Key license and trade contracts: Tel Aviv University. Technological expertise: F, BA, CS Main products/instrumentation under R&D: Bioremediation, specialty chemicals, contract manufacturing products, cosmetics, pesticides, biodispersant, biodegradation. Main products/instrumentation under R&D: Biochemicals, detergents.

2964 2962

ZMATION, INC.

Add: 14811 NE Airport Way Ste. 200 Portland, OR 97230-8301 Tel: (503) 654-9793 Fax: (503) 653-5334 President: Craig D. Howard Research director: Curt Gebers R&D expertise: Research and production of automation systems, with focus on motion, vision dispensing, and other high process intensive applications. Key sales market contracts: Cognex, IAI, Trilogy, Tech-con, Precision. Technological expertise: PMC, R, BME Principal products/instrumentation: Z-300 Automatic Dispensing system; Z-UAP Universal Automation Platform.

ZOION DIAGNOSTICS, INC.

Add: 159 Memorial Dr., #C Shrewsbury, MA 01545-4030 Tel: (508) 799-9477 Fax: (508) 799-9477 E-mail: sgitis.zoion.diagnostics@worldnet. att.net President: James Hughes Research director: James Hughes, Ph.D. R&D expertise: Bioprocess engineering research, manufacture of business incubator, bio-science products. Technological expertise: E, F, PA, P/S, LP, RD, PMC, PIS, BA, AF, BI Principal products/instrumentation: FastStain™ — one-hour stain for SDSpae gels; Quickstain™; antigens, serum products, human tissue extracts, biologicals, single cell proteins, antibiotics, specialty chemicals.

2965 2963

927

ZONAGEN, INC.

ZOHAR DALIA, BIOTECH

Add: Kibbutz Dalia 19239 Israel

Add: 2408 Timberloch Place, B-7, The Woodlands, TX 77380

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Tel: (281) 719-3400 Fax: (281) 719-3446 President/CEO: Joseph S. Podolski Research director: Peter J. Keileher, Ph.D. R&D expertise: Development and manufacture of human reproductive healthcare products, vaccines, and vaccine adjuvants; research and development of other biotechnology medicines. Key sales market contracts: ScheringPIough — worldwide; Vasomax. Key license and trade contracts: NTH, U of PA. Technological expertise: E, F, PA, BA, C/TC, DD, H/CF, PIS, P/S, R, P, SY, SMC Principal products/instrumentation: Vasomax for erectile dysfunction. Main products/instrumentation under R&D: Vasofem™ for female sexual dysfunction, Bimexes™ and Erxin™ for erectile dysfunction, ImmuMax™ and ImmuMaxSr™ vaccine adjuvants, Zproxal™ for hormone-independent prostate tumors, unnamed product for hormonedependent prostate tumors, Contrel™ for vaginal spermicide/microbicide, vaccine adjuvants, immunocontraceptives. Sealed and granted patents: Vasomax use and compositional, vaccine adjuvants, immunocontraceptives.

applications and microparticle delivery for DNA; therapeutic item development and drug delivery applied research, various products manufacture. R&D collaboration: Pasteur Merieux Connaught — drug discovery collaboration. Technological expertise: D-D, DD, BI, GT, DDI, DK Main products/instrumentation under R&D: BIOTOPE deliver in ensphere for HPVcervical dysplasia, Phase II; BIOTOPE for treatment of HBV, Research; BIOTOPE treat Juvenile Diabetes, Research; immunogenic peptides from the HPV E7 protein; ZYC101a for HPV-cervical dysplasia HPVanal dysplasia. Sealed and granted patents: DNA methods for immune suppression and immune activation, DNA delivery using microspheres; Immunogenic peptides from the HPV E7 protein, 6,582,704, U.S.

2967

ZYLEPSIS, LTD.

Add: 6 Highpoint Henwood Business Estate Ashford Kent TN24 8DH U.K. Tel: (44) 123-366-0555 Fax: (44) 123-366-0777 E-mail: [email protected]

2966

ZYCOS, INC.

President: A.V. Korda Research director: Dr. J. Sime

President/CEO: Dr. Mark A. Philip

R&D expertise: Bioresearch and development of biotechnologies, focusing on discovery and development of key functional ingredients for foods and personnel health care products using biotransformation technology; food and cosmetic ingredients.

Research director: Dr. Mary Lynne Hedley, Dr. Roman Chicz

R&D collaboration: Collaboration with SmithKline-Beecham.

R&D expertise: Research of Antigen discovery, DNA expression vectors for therapeutic

Key license and trade contracts: Food ingredients with Denisco.

Add: 44 Hartwell Lexington, MA 02421 Tel: (781) 274-6500 Fax: (781) 274-0839 E-mail: [email protected]

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Technological expertise: E, F, CC, BA, P/S, SMC, SY Main products/instrumentation under R&D: Cosmetic ingredients, including suncare, sunscreen cream, anti-aging agents and preservatives.

2968

ZYMARK CORP.

929

Subsidiary bodies: Subsidiaries in Canada, Germany, United Kingdom, France, Switzerland and Japan.

2969

ZYMED LABORATORIES, INC.

Add: 458 Carlton Ct. S. San Francisco, CA 94080

Add: Zymark Center Hopkinton, MA 01748

Tel: (650) 871-4494

Tel: (508) 435-9500

Fax: (650) 871-4499

Fax: (508) 435-3439

E-mail: [email protected]

E-mail: [email protected]

President: Dean Tsao, Ph.D.

President/CEO: Kevin Hrusovsky Research director: Bruce Bal

R&D expertise: Development and manufacture of diagnostic and immunochemical products.

Subsidiary of Berwind Group.

Key sales market contracts: VWR.

R&D expertise: Research and production of laboratory automation solutions for biopharmaceutical and biotechnology, including high throughput screening, organic synthesis, combinatorial chemistry and ultra HTS.

Technological expertise: E, F, PA, GA

Key sales market contracts: For Twister Universal Microplate: Biotek Instruments, Molecular Devices Corporation, Packard Instruments, Skatron Instruments, BMG Instruments, EG&G Wallac, Dynex, Perkin Elmer, Tropix, Tricontinent Through OEM Agreement Labsystems, Tecan, PerSeptive Biosystems, additions to Twistercare. Automation Certified filters: Millipore Corporation. Automation Certified Microplate Pipet Tips: QSP Plastics, NS to Twistercare. Technological expertise: COC, HTDS, R, SY, PG, CS, BME Principal products/instrumentation: Turbo Vap® evaporation workstation; Twister™ Microplate Handler; RapidPlate™ Pipetting Workstation; Presto™ Microplate labeler; Presto™ Microplate Sealer; Allegro™ Screening Systems; Virtuoso™ Assay Automation System; Presto™ Liquidhandler. Main products/instrumentation under R&D: Laboratory automation solution for HTS.

Principal products/instrumentation: MAK-6® monoclonal anti-cytokeratin cocktail; Histostain®-Plus Kit; PicTure®-Plus Kit. Main products/instrumentation under R&D: BEAT™ blocker, immunochemical reagents. Sealed and granted patents: BEAT™ Blocker.

2970

ZYMOGENETICS, INC.

Add: 1201 Eastlake Ave. E., Seattle, WA 98102-3702 Tel: (206) 442-6592 President: Susan Specht R&D expertise: R&D and production of biotech drugs. Technological expertise: DD, D-D, AR. Main products/instrumentation under R&D: Phase II trial of recombinant interleukin-21 (IL-21) in the treatment of metastatic melanoma. Of the 24 patients, 29% showed a partial response, with an additional 33% showing stable disease, 2009.

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REFERENCES

1. Zhan Zhengsong. Medicinal Hygiene of the 21st Century [Chinese]. Anhui Science and Technology Press, Hefei, 2002 2. Zhan Zhengsong. Clinical Safety and Rational Application of Cytokines [Chinese]. Chemical Industry Press, Beijing, 2005 3. Zhan Zhengsong. Information Handbook of Medicinal and Biotechnology Enterprises [Chinese]. Chemical Industry Press, Beijing, 2007 4. Ministry of Public Health, P. R. China; State Administration of TCM, P. R. China; FDA, P. R. China et al. Inheritance, Development and Health Improvement — Exhibition of

5. 6. 7.

8. 9. 10. 11.

931

Traditional Chinese Medicine, Beijing, China, 2008 John Sterling. Directory of Biotechnology Companies. Liebert, New York, 2001 Anonymous. Clinics and Patents. Biotechnology News 30(4), 2010 Gene therapy, drug discovery, biotechnology products. Genetic Engineering News. Vol. 22–30, 2002–2010 http://www.genengnews.com http://ep.espacenet.com/ http://www.genengnews.com/newproducts/ http://resource.emagecompany.com/big5/ medicine/gmp.html

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KEYWORDS INDEX

Note: The numbers listed here refer to the item numbers in the List of Enterprises. AAV gene therapy 269 Absorbable collagen membrane 1491 Acceleating the drug discovery processes 610 Accelular Dermal Graft 1701 Accu-jet pipette controller 568 Accuprobe System™ 835 Accurate External Run Controls 561 Acid-base home biochemistry kit 1618 ACTID 880 Acti-nobelillus/pasteurella vaccine 1093 Activating enzymes 315 Active alent transport systems 1028 Active biopharmaceutical ingredients 2401 Active implantable medical device 899 Active pharmaceutical ingredients 943, 944 ACT™ (LMTP-PE) 1575 ACUTECT 934 Acute EIA System 863 AC Vaccine™ technology 260 Acyclovir CD 2561 ADCON®-L 1266 ADCON®-T’N 1266 Additional Bactosome 861 Adenosine A1 (antagonist CVT-124) 386 Adenosine Al agonist 849 Adenoviral packaging cell line 1527 AD-FX (Attention Deficit Disorder) 848 Adoptive Cell Therapy 425 Adrenoleukodystrophy test 1221 Adult and pediatric vaccines 803 Adult donor bovine serum 840 Advanced Bio Cultures 2595 Advanced diagnostic 2666

Advanced GenomX tools 2881 Advanced monoclonal antibodies 2730 Advanced prognostic panels for prostate and bladder cancer 868 Aerobic waste treatment system 28 Aerosol Barrier Tips 808 Affinity chromatography 1068 Affinity chromatography columns and media 2270 Affinity-isolated antibodies 163, 329, 1565 Affinity ligands for separations 984 Affinity purified antibodies 1123, 1411, 1627 Affinity purified antigen 1430 Affinity purified polyclonals 491 Afif for diabetic microvascular complications 1099 Agar extraction technology 635 Aging therapeutic drug 1230 Agricultural pesticide 2961 Agricultural test kits 2144 Agriculture pesticide 202 Agrobacteriocin 202 AHF 1206 AIDS and cancer treatment drugs 1756 AIDS mAb 1416 AIDS vaccine 684, 1756, 1838 Air Biofilters 1037 Airborne contamination control fumigation equipment 700 Air Flow Monitor 1301 Air monitoring systems 1281 Air Particle Counter 2136 Air pollution control equipment 1887 933

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Air quality monitoring equipment 1281 Air washer 1281 Albumin 1429 Albumin animal organs 213 Alcohol dehydrogenase 548 Aldesleukin 735 Aldurazyme 404 Alferon N injection 1507 Alglucosidase myozyme 1248 Alicaforsen/2302 1548 Alimta 1016 Allergy diagnostics tests 545 Allergy vaccine 583, 971 Allograft transplantation system 540 Allomune humanized anti-CD2 MAB 540 All therapeutic molecules 423 Alpha-galactosidase 2790 Alpha-I-Antitrypsin 2289 ALT-chronic hepatitis therapy 870 ALVAC-IL-12 vaccine 1957 Alzheimer disease therapeutics 23, 121, 235, 1230 Alzheimer’s disease therapeutic technology 1266 Alzheimers drugs 2207 Alzheimers therapeutics 688 Alzhemed 1992 Ambient air monitoring analyzer 744 AmBisome 2009 Amino acid analyzer 644 Amino acid-2-clorotrityl resins 772 Amino acid derivatives 250, 886, 2110 Ampakines 819 Amphiistrep B 1445 Amplifiers 889 Ampligen 1332 AMV reverse transcriptase 1117 Amylase 315 Amyloid Antagonist 819 Amyloid A protein 543 Amyloidosis test 1221 Anaerobic bioremediation process 2943 Anaerobic tissue processor 585 Anaerobic wastewater treatment systems 1461 Analysis instruments for drug discovery 2138 Analytical and control software 893

Analytical and measuring instruments for drug R&D 1714 Analytical biochemistry reagents 1697, 2300 Analytical grade reagents 1094, 2901 Analytical instruments 792, 1495 Analytical instruments and reagents 323, 324 Analytical instruments for HPLC 222 Analytical instruments software 1786 Analytical reagents 1637 Analytical reference materials 722 Analytical sensors 1638 Analytical sieve shaker 2433 Analyzer for clinical medicine concentration 2337 Analyzer for laboratory research drug concentration 2609 Analyzer for medicine concentration 1094 Angiocol 498 Angiogenic gene therapy 1210 Angiogenic inhibitors 1043 Angiogenesis therapy 2858 Angong Niuhuang wan 730 Animal and human cell cultures 1088 Animal and human insulin preparations 337 Animal and human sera 342 Animal blood fraction 1642 Animal caging and biological storage systems 162 Animal cDNA 463 Animal cell culture 393, 775, 2656 Animal feed supplement 240 Animal health novel products 1834 Animal health products 1338 Animal Sera 2656 Animal sera for cell culture 1269 Animal serums 213 Animal tissues 213 Anipryi 909 Annamycin 214 Antegren 236 Antiaging agents 1416 Antiaging enzyme 373 Anti-AIDS agent 662 Antiallergic drug 2379 Anti-Alzheimer agent 2042 Anti-angiogenesis therapy 2696

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Keywords Index Anti-angiogenic and anti-invasive compound 159 Antiangiogenic drugs 53 Anti-AsialoG Ab 2897 Anti Beta2 Glycoprotein 812 Antibiofilm coatings 1782 Antibiotics 520 Antibiotic Severe Hypersensitivity Microwell ELISA Tests 83 Antibodies 42, 374, 402, 409, 447, 466, 470, 476, 515, 525, 623, 650, 678, 691, 710, 721, 753, 760, 789, 823, 842, 859, 878, 913, 923, 946, 959, 989, 1336, 1374, 1421, 1675 Antibodies against polypeptides 1169 Antibodies for cardiac markers 1136 Antibodies to all 2781 Antibodies to a YYX epitope 642 Antibodies to Cardiac Markers 491 Antibodies to tumor markers 2944 Antibody 1673 Antibody and antigen components for diagnostic test kits 1136 Antibody-based chip 2261 Antibody-based drug 1861 Antibody conjugates for cancers 677 Antibody finger printing 265 Antibody-free Chip 2328 Antibody-free donor calf serum 624 Antibody fusion protein 1157 Antibody gene repertoires 609 Antibody in plants 1057 Antibody Library 1924 Antibody-liposomes delivery system 998 Antibody non-detectable donor calf serum 400 Antibody-peptide delivery system 998 Antibody purification kits 1940 ANTIBODY REAGENTS 1096 Anticancer & Alzheimer biotech medicines 1472 Anticancer agents 26, 293, 715, 1256, 1746 Anticancer compound 145, 396 Anticancer drug 87, 301, 620, 895, 1814, 1915, 2153 Anti-cancer drug (Tubulin) 878 Anticancer oligo targeting P53 1337 Anticancer peptide 286, 2180 Anticancer pharmaceuticals 605 Anticancer vaccine 65

Anti-cancer (VEGF-Antagonist) 1578 Anticarcinogenic MAb 1742 Anti-cardiolipin 812 Anticardiolipin antibodies 56, 146, 279, 1799 Anti-coagulant 523 Anticonvulsant & antimigraine 776 Anti-cytokine therapy 2942 Antidiabetic agents 1677 Antidiabetic compounds 1622 Antidiabetic peptides 286 Anti-D Immune Globulin 622 Anti-DNA antibodies 146 Anti-DNA antibody 543 Antiendotoxemia serum 2854 Anti-Epitope tag antibodies 265 Anti-factor VII Mab 692 Anti-fibrotic biopharmaceuticals 754 Antifibrotic therapeutics 1113 Antifreeze professional proteins 60 Antifungal agents 82 Anti-gamma reagent 331 Antigen detection EIAs 1559 Antigen discovery 2966 Antigens 930 Antigens and antibodies of HCV 2775 Anti-gp39 1386 Antihemophilic Factor 104 Anti-hepatits-B Ab (Hepagam B) 621 Anti-HIV 2860 Anti-HIV drugs 98, 136, 561 Anti-idiotype antibody vaccine 2769 Anti-IgE antibody 2695 Anti-infective agent 1746 Antiinfective drug 450, 1503, 2388 Anti-inflammatory antibody 692 Anti-inflammatory drug 2066 Anti-inflammatory natural products 2210 Anti-interleukin-1 receptor 1368 Anti-leukemic drug 866 Anti-microbial peptides 2192 Antimicrobial 1524 Anti-microbial coating 230 Antimicrobial resistance engineering peptides 1929 Antimicrosomal antibodies 306 Anti-myeloma monoclonal antibody 2832

935

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Anti-neurodegenerative drug 878 Antinuclear antibodies 57 Antiobesity novo drugs 1953 Anti PDGF Mab 677 Antipeptide antibodies 506 Antiplatelet antibody for angioplasty 692 Anti-Platelet Nutraceutical 2465 Anti-psoriatic agents 1132 Antisense antiviral agent 267 Antisense drug 267, 1098 Antisense oligonucleotides 1493 Antisense RNA synthesis 1619 Antisense RNA synthesis phosphoramidites 712 Antisense treatment drugs 241 Antisera human proteins 1613 Antistroke drug 776 Antithyroid antibodies 58 Anti-TNF 677 Anti-TNF antibody 692, 2349 Antitumor compounds 2216, 2221 Antitumor gene therapy 1762 Antitumorigenic agents 1728 Antiviral antibodies 136 Antiviral drug 2608 Anti-viral drug susceptibility and resistance 2868 Antiviral immunity therapy 2823 Antiviral pharmaceuticals 1334, 2871 Antivirals 738, 2792 Apc gose immunobased therapy 904 Apheresis technology 578 Apitvus co-administered with 200mg of ritonavir 558 Apligraf™ for venousulcers 2105 Apolipoprotein assay 1925 Apoptosis 74 Apoptosis drug discovery route 882 Apoptosis kits and reagents 1509 Apoptosis peptides 489 Apoptosis Reagent Kit 1463 Apostosis Detection Kits 544 Apostosis Research Reagents 544 Apotosis in cancer 423 Apparatus for nucleic acid sequencing 1700 Apparatus for spinning spider silk protein 2008 Applied biomedical system 2169

Aptosyn exisulind for colon multiple adenoma 669 Aquaculture 1572 Aquascreen 1288 Aqueous Treatment System 542 Argogel Resin 210 Argretin Oral and Topical 1710 Armodafinil (Nuvigil) 697 Array® Detector 1073 Array™ 21 Micro Array Systems 1235 Array-pro analyzer 1795 Artemisinin 1282 Arthritogenic Monoclonal Antibodies 737 Artificial bone marrow 1148 Artificial capillary cell culture systems 661 Artificial chromosomes 745 Artificial liver 1195 Artificial seed culture technology 2911 Artificial synthetic matrixes 841 Artificial synthetic spinal fluid 841 Aseptic sampling devices 2380 Aspirate & Dispense Platform 365 Assay for cell mediated immunity 859 Assay kits 2085 Assay predicting response to antihypertensive treatment 1086 Assays for poultry 1388 Assay to detect trypsinogen activation peptide 541 Associated software for gel analysis 2806 Asthma therapeutic 1194 Atherosclerosis gene therapy 2350 Atherosclerosis QRS 10001 APO Al Analog 846 Atomic force microscope 940 Atragen 214 Atripla 1259 Auotomatic Sampling SYS 2013 Authentikit System 1464 Autoblot 1180 AutoChem workstation 1864 Autoclavable and in situ bioreactors 196 Autoclavable fermenters with microprocessor control 1012 Auto Fluorescent Visualization Proteins 2361 Autoimmune antigens 1872 Autoimmune disease diagnostic kits 1422

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Keywords Index Autoimmune disease diagnostics 1468 Autoimmune Disease IFA and ELISA kits 2740 Autoimmune diseases therapeutics 2408 Autoimmune Tests 762 Autoimmunity drug 328 Autologous tumor vaccine virally modified 534 Autologous Vaccines for the treatment of cancer 620 Automated analysizer 194 Automated cell injection 193 Automated Colony Counter 1722 Automated Computerized Microscope 2712 Automated DNA extraction 1358 Automated DNA isolation 985 Automated DNA preparation 1064 Automated DNA Sequencer 1174, 1700 Automated high-throughput DNA sequencer 130, 131 Automated High Throughput Screening System 2774 Automated Immunohistochemical Staining device 1671 Automated immunostaining system 385 Automated instruments for sample preparation 2706 Automated liquid handling/sample preparation instruments 1261 Automated liquid-handling system 1063 Automated Metaphase Finder 1722 Automated Micronucleus Assay 1722 Automated microplate analyzer 1670 Automated microplate processing systems 651 Automated Nucleic Acid Extraction 254 Automated Optical Biosensor 1667 Automated peptide synthesizer 839 Automated plastic instruments 210 Automated plated sealer 2850 Automated processor for solid phase extraction 194 Automated protein association and aggregation system 2927 Automated robotic platforms 1064 Automated sample injector 1350 Automated Staining Apparatus 385 Automated systems of drug discovery 1721

937

Automated Target RNA Preparation 308 Automated titrating high stability filter fluorometer 271 Automated Viability Analyzer 308 Automated workstations 1840 Automatic analyser 1153 Automatic blotting system 1749 Automatic DNA sequencer 2522 Automatic dosing pump 1490 Automatic endotoxin detection system 226 Automatic pipetting workstation 1298 Automatic software for infrared diagnosis 311 Automatic synthesizer 1153 Automatic Thermal Analysis 311 Automatic titration workstation 1864 Automation research robotics 2716 Autoradiographic instruments 490 Autoradiography cassettes 1254 Auto-Sep Protein Purification System 1129 Avian Adenovirus Protein Expression Kits 1200 Avian Adenovirus Protein Expression Vectors 1200 Avian interferon 394 Avonex Interferon BETA — la 386 Axicidin™ cancer therapy 1984 Axokine® for obesity 2413 AZX100 2115 B&T cell growth factor 1394 Bacillus licheniformis expression system 520 Bacillus strains 2082 Bacterial culture 1049, 1960 Bacteriological culture media 303, 1364 Bactolysins 1859 Baculovirus Expression System 1534 Baculovirus expression vectors 72 Balsam Fir Hybrids 1134 B-amyloid ELISA kits 489 Barrier with doxycycline 245 Baseline-range of genomics processing modules 2739 Base Reader Kits 1056 Basic Fibroblast Growth Factor 1594 BatchPro Designer 1499 B-cell epitope peptides 1294

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BDS process technology of biocatalyst genes 1034 Bead-based multiplexing system 1736 Bead-bed reactor 17 Bebulin 1429 Behavioral monitor 330 Bench scale fully automated fermenter 217 Bench-top 1450 Benchtop cooling incubators 559 Benchtop microcentrifuge 640 Benchtop Tube Cooler 907 Benchtop ultracentrifuge 308 Benchtop ultratherm 705 Benefix 583 Beta-amyloid fragments 2569 Beta-Carotene 1976 Beta carotene rich powder 1971 Beta-IFN 386 BetaKine 1474 Beta-lactoglobulin karyotyping 565 Beta-lmager 490 Betaseron 320 Betathirte for cancer 964 Bevacizucmab (Avastin) 1186 BianNai Tong Tea 2926 Bibliographic software packages 1547 Big bore plate washer for solids removal 939 Bile acid sequestrant 1161 Binary vector system 2950 BIO 2+ 1044 Bioactive analytic equipment 428 Bioactive peptide 430, 1092 Bioanalyser 2504 Bioanalytical testing 465 Bioarrays and chips 1098 Bioartificial pancreas 1978 Bioassays for rapid low-cost prescreening of environmental pollutants 1889 Biobed Expanded Granular Sludge Bed 532 Biobypass® therapeutic angiogenesis 1244 Biocart/CAFCA-system 147 Biocatalytic desuliurizanon 1034 Biocatalytic technology 1715 Biochemical drug 1092 Biochemical reagents 1092, 1377 Biochemicals 487, 1076, 2392, 2963

Biochip 1268, 1368 BioChip Arrayer™ non-contact microdispensing system 2137 Biochip instruments 1954 Biochips 1358, 1500, 1734 Biochromatography media 1127 Biocleanser 1037 Biocode 1314 Bioconjugates 477, 631 Biocontrol treatments of seed 683 Biocor 1111 Biodegradable polyesters 1569 Biodegradable polymers 1833, 2065 BioDesign Dialysis Tubing™ 361 BioDesign Gel Wrap™ 361 Biodispersant 2963 Biodrug technology corporate profiles 366 Biodrug technology information 366 Bioelectrochemical devices 1156 Biofeasibility assays 1845 Biofeedback devices 406 Biofungicide 68, 1884, 1717 Bio-fungidde 960 Bio gas analyser 744 Biogel oil spill bioremediation gel 2069 Biogranules 432 Biogrid 468 Bioherbicides 830 Bioimaging agent 2402 Bioimaging Workstation 2055 Bio-Incubator 2857 Bioinformatics & computational biology 1480 Bioinformatics drug discovery 1898 Bioinformatics software 538, 1226, 1285, 1769 Bioinformatics systems solutions 1253 Bioinformatic tools 799 Bioinformatic work tool package 1916 Bioinformation network of novel drug development 996 Bioingredients for foods 2025 Bioinsects 1741 BioKey assay 1601 Biologic adhesives 1295 Biological & immunological reagents 1068 Biological agent 1026 Biological buffers 1149

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Keywords Index Biological clarification 844 Biological control agent 339, 1847 Biological cultures 233 Biological defense modifier 1026 Biological Insecticidas 1458 Biological liquid nitrogen refrigerators 806 Biologically active buffers 430 Biologically active enzyme substrates 2182 Biologically-active molecules 2713 Biologically active peptides 1986, 2183 Biological membrane reactor 896 Biological prefiltration 844 Biological protection of crops plant diseases 443 Biological reagents 2151 Biologicals 590, 1451, 1853 Biological safety assessments 40 Biological safety cabinets 1611, 1857, 2053, 2506 Biological Shakers 2000 Biological sterile filtration 844 Biologicals vaccines 1811 Biological systems for production of marine invertebrate and microbial natural products 598 Biological transfer bottles 992 Biologics delivery of proteins/peptides 2269 Biology and chemistry database 698 Bioluminescence instrument 2333 Bioluminescent probe 1162 Bioluminescent cell viability assay 2137 Biolyzer rapid analysis system 993 Biomagnetic stem cell isolation device 2576 Bio Manufacturing Synthesizer 839 Biomaterials 343, 409, 453, 528, 593, 607, 631, 648, 652, 653, 660, 691, 710, 739, 780, 879, 903, 1033, 1036, 1067, 1069, 1080, 1104, 1740, 2870 Biomedical analytical instruments 2758 Biomedical CD-ROMs 551 Biomedical devices 2220 Biomedical devices for drug research 1869 Biomedical equipment 370, 981 Biomedical equipment for drug research 791 Biomedical equipment/instruments 2619, 2621 Biomedical lab equipment 2334

939

Biomedical laboratory equipment 154, 1604, 2626 Biomedical laboratory equipment for drug research 1013 Biomedical laboratory instrumention systems 1063 Biomedical products immunoassays diagnostics 412 Biomedical research equipment 1614 Biomedical research workstations 444 Biomelanin 1167 Biomerieux 1801 Biomolecular assays devices 427 Biomolecules extracted from bovine colostrum 753 Bionematoicide 1884 Biopesticides 49, 960, 1011, 1026, 2590 BioPharmaceutical containers 706 Biopharmaceutical for allergy drug 875 Biopharmaceutical products 255 Biopharmaceuticals 59, 179, 186, 268, 436, 604, 611, 614, 674, 748, 888, 913, 943, 947, 975, 1006, 1033, 1079, 1240,1368, 1584, 2090, 2214, 2319, 2327, 2354, 2387, 2676, 2718 Biopharmaceutical systems 2093 Biopick 468 Biopicker 1494 Bio-polychemicals 718 BioPolymer Arrays 477 Bio Power® silage inoculant 2059 Bioprocess containers systems 1361 Bioprocess engineering equipment 2714 Bioprocess engineering technique 2501 Bioprocess engineering technologies 2232 Bioprocess engineering technology 1557, 1723 Bioprocessing equipment 8 Bio Process monitoring 858 Bio R&D Synthesizer 839 Bioreactor 2170 Bioreactor-control software 370 Bioreactors 8 Bioreactors for protein and antibody 1567 Bioreactor Skids 1625 Bioreactors membranes 190 Bioreactor systems 195, 2905

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Bioreagents 596, 2085 Bioreagents for drug discovery 143 Bioremediation 397, 405, 588, 691, 710, 739, 892, 960, 1036, 1250, 1324, 1768 Bioremediation reactor 1045 Bioremediation technologies 867 Biorepressor biotherapeutics 533 Bioremediation 1309 Biorobotics 468 Biosafety cabinets 1588, 2757 BioSafety testing 465 Biosafety testing method 2869 BioSCOUT™ 1716 BioSeed 1049 Biosensor 31, 35, 397, 409, 520, 588, 589, 607, 617, 636, 653, 660, 691, 708, 718, 738, 750, 768, 977, 1020, 1063, 1066, 1110, 1141, 1149, 1156, 1159, 1421, 1626, 1813, 1848, 2076, 2479, 2486, 2700 Biosensor Arrays 244 Bioseparation products 2779 Biosimilar drugs 2409 BiosLife2 1319 BioSolutions 567 Biosolvent for oil spill clean-ups 867 Biospecific antibody for treatment 1793 Biostretch systems 1376 Biosupport Medium 1783 Biosynthesis gene clone 2612 Biosynthesis genes 2729 BiosyntheticViro Vectors 1972 Biotage chromatography purification products 984 Biotech diagnostic/therapeutic 2109 Biotech drug 333, 1100, 1112, 1545, 1552, 2351, 2457, 129, 2166, 2670, 2930 Biotech lab equipment 788 Biotech laboratory equipment 493 Biotech labwares 788 Biotech medicines 60, 1243, 1307, 1446, 1665, 1723 Biotech medicine softwares 1989 Biotechnological drugs 1865, 2206 Biotechnological softwares 1547 Biotechnology antibodies 253 Biotechnology drug 263,1836, 2225

Biotechnology instruments 530 Biotechnology/medicine and devices 305 Biotechnology medicines 348, 408, 756, 816, 871, 1029, 1912, 2130, 2160 Biotechnology medicine software 25 Biotechnology new drug products 573 Biotechnology products plants 2445 Biotechnology research reagents 1146 Biotechnology software 954, 958, 978, 1253,1852, 2577 Biotechnology software web 956 Biotechnology tools 314 Biotech research reagents 1637 Biotech software 195 Biotechware 1149, 1270 Biotelescanner 1085 Biotest 343 Biothane Upflow Anaerobic Sludge Blanket 532 Biotherapeutics 1100, 1268, 1484 BioTherm thermocyclers 2646 Biotin/avidin detection systems 2848 Biotin enzymes 1112, 1268 Biotin reagents 329 Biotinylated probes 1163 Biotinylation reagents 135, 2312 Biotinylation kits 2575 Biotox process 1191 Biotrace 343 BioView control software 25 Biovine virus diarrhea vaccine 32 Bi-valent vibriosis vaccine 1868 Blood bags 706 Blood bag shakers 995 Blood borne pathogens 1237 Blood filtration devices 2669 Blood glucose level monitorsplans 636 Blood Grouping Reagents 2563 Blood plasma substitutes 654 Blood pool agent 1061 Blood pool MRI contrast agent 1061 Blood preparation 2476 Blood screening tests for hepatitis C virus 734 Blood Sterilization 2860 Blood substitute 910, 918, 645, 990, 1329, 1381 Blue TransCyt Filters 884 BNCT compunds for cancer 560

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Keywords Index Body Synergy 1319 Bonded silica phases for preparatory/process separations of peptides and chiral drugs 584 Bone and cartilage markers 1837 Bone graft devices 827 Bone Graft Substitute 2764 Bonemarkers 930 Bone marrow toxicity testing 767 Bone metastases therapy 870 Bone morphogenetic protein 418 Borne particle counters 531 Boron analogues of amino acids and peptides 560 Boronated antisense strands nucleosides 560 Boronated nucleoside triphosphates 560 Boron neutron capture therapy 560 Borrelia (Lyme) 1168 Botulism Antiserum 2854 Botulism antitoxin 177 Bovine immunoglobulin 910 Bovine mastitis vaccines 2855 Bovine parentage verification PCR tests 565 Bovine pharmaceutical grade fully traceable origin components 2045 Bovine somatotropin 524 Bovine Thrombin 1296 Brachytherapy seeds 1515 Brain-derived neurotrophicfactor 2413 Brand filters-membranes 47 Brasofensine 1997 Breakthrough technology for drug screening and sequencing 2531 Breast and ovarian cancer genetic test 1949 Breast cancer vaccine 446 Breeding of new laboratory animals 702 Breeding true animal 165 Brilliant Solutions™ blood products 2863 BT insecticide 1632 BTX gas analyser 744 Buffer Dilution Systems 2714 Bug-Bank 1324 Building blocks for Nucleotide synthesis 2018 BXN™ cotton 599 Cadherin modulators 26 Calanolide A for HIV infections

2480

941

Calatonin 1028 Calcitonin CD 2561 Calcium channel blocker 1995 Calibration devices 18 Calibration Manager™ Software 553 Calorimeter measuring devices 1398 Calpain Inhibitors 819 Calsitoriol 1825 Cambridge Biotech HIV-1 Western Blot Kit 606 Camera Tracking System 889 Campath® alemtuzumab 1879 Campath 1H 583 Campylobacter vaccine 171 Cancer 594 Cancer antigens 451 Cancer Assay 1401 Cancer biopharmaceuticals 998 Cancer diagnostic kits 481 Cancer diagnostic reagent 2693 Cancer immune surveillance test 1750 Cancer immunotherapeutic 2858 Cancer research antibodies 6 Cancer suppressor 2124 Cancer therapeutic agent 1444 Cancer therapeutics 1277 Cancer therpy 2650 Cancer vaccine 666 Cancer vaccines 1415 Candidate protein for obesity 1238 Canine Somatotropin-CST 571 Capillary electro chromatography Columns 1366 Capillary electrophoresis 428 Capillary gradient electro-prorsis system 1452 Capital equipment for lab drug research 1317 Capital equipment for pharmaceutical industry 1193 Captisol™ 857 Carbohydrate analyzer 1934 Carbohydrate binding proteins 2890 Carbohydrate Electrophoresis kits 417 Carbohydrate reagents 2462 Carbohydrate Standards 1275 Carbon fiber rotors 798 Carbon filter tip 1902 Carbon momoxide sensors 1110

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Carboplatin 93 Cardiac enzymes 818 Cardiolipin 1422 Cardiovascular risk marker 1133 Cardiovascular therapeutics 1807 Carrier protein 543 Cartilage Regeneration Matrix 1491 Cartridge Filters 1160 Caspase inhibitors and activators 882 Catalogue antibodies 1424 Catalogue peptides 1424 Catalytic Antibody 1337 Cataract removal device 241 Catezomes 783 Catheptic enzymes 340 CD4/CD8 monitoring kit 1525 CD8 cell separation kits 881 C. difficile toxin A purification method 1690 CD40 ligand 1418 CDNA characterization primer kit 1177 CDNA Expression Arrays 768 CDNA libraries and screening 1224 CDNA synthesis method 2039 CD-ROM-related computer hardware 551 Cell adhesion inhibitors 386 Cell adhesion molecule 642 Cell adhesion molecule transcription 319 Cell analyzer 454 Cell and gene therapy 676, 1089 Cell and molecular biology reagents 1760 Cell and tissue culture 395, 502, 815, 1118, 1304, 1376, 1399, 1642, 2098, 2162, 2174, 2294, 2602 Cell and tissue culture plant-derived compounds 2244 Cell bank 1152 Cell-based biosensors 637 Cell-based cancer vaccines 904 Cell biology antibodies 488 Cell Bioreactor 1037 Cell collection 578 Cell Concentrator 1330 Cell culture 879 Cell Culture Antifoaming Reagent 1534 Cell culture apparatus 358 Cell culture bioreactor system 1730

Cell culture/fermentation tube 1135 Cell Culture grade Fetal Bovine Serum 2728 Cell culture kits with normal human cells 2331 Cell culture media 375, 545, 1361, 1436, 1608, 1727, 1796, 2897 Cell Culture Media and Reagents 1709 Cell culture reagents 840, 1377 Cell culture roller bottles and flasks 668 Cell cultures for virus isolation and identification 545 Cell Culture Stirrers 2709 Cell culture systems 1974 Cell culture ware 305, 815 Cell cycle controller 1683 Cell density monitoring 2526 Cell directed inhibitor 454 Cell dispersion devices 1842 Cell Disrupter 493, 807 Cell disruption 1264 Cell disruption devices 1842 Cell disruption homogenizers 200 Cell disruption unit 569 Cell encapsulator 1467 Cell function diagnostics 632 Cell, gene & tissue based therapies 1436 Cell growth and attachment factors 416 Cell growth media 611 Cell growth monitor 187 Cell Harvesters 615 Cell homogenizers 217 Cell injection and patch clamp workstations 1065 Cell Isolation Technology; human or mouse genes; HLA Antibody Analysis system technology 1534 Cell lines 1433 Cell lines expressing SPCR 1090 Cell lines for protein production 745 CellMicroSieve™ nylon filter matrix 361 Cell permeable fluorogenic Caspase-3 substrates 2087 Cell potency bioassays for biotech products 674 Cell proliferation reagents 2236 Cell Robotics Workstation 671 CELLscan Fluorescence Microscopy 2488 Cell-selecting devices 1121

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Keywords Index CellSelector™ 671 Cell separation composition and methods 372 Cell separations devices 17 Cell separation system 696 Cell Sep’Nsystem 117 Cell-signaling assays 1721 Cell Signaling Reagent products 211 Cell surface receptor 642 Cell therapy 767, 922, 1152 Cell Therapy-Parkinson’s Disease 571 Cell therapy program 256 Cell therapy technology 1333 Cell/tissue culture 806, 918, 980, 990, 997, 1329, 1367, 1552, 1096, 1975, 2035, 2675 Cell/tissue culture products 117, 349, 525 Cell/tissue/organ preservation solutions 1796 Cellular & molecular biology reagents 1669 CellularEssentials 1319 Cellular therapy 920 Cellular therapy 920, 1390, 2385 Cellular transplantation therapy 920, 1248 Cellulase enzyme technology 1602 Cellulose binding domain 649 Cell Washer 1330 Centrifugal extractor 1340 Centrifugal separators 2910 Centrifugal ultrafilter 1340 Centrifugal ultrafiltration 2434 Centrifugal ultrafiltration devices for large volumes 2275 Centrifuge filters 1952 Centrifuge rotor 81 Cerebrovascular Isdiernia/Reperfusion 951 Cerestat 613 Cetuximab (Erbitux) 1406 Chaperonin proteins 608 Characterization of recombinant proteins 1091 Charged particle detector 800 Charge Injection Device 750 Cheezheng Tibetan medicine pain relieving plaster 707 Chemical intermediates for DNA-RNA synthesis 712 Chemical metering pumps 291 Chemical recovery systems 2021 Chemicals 150

943

Chemicals for DNA research 1265 Chemicals for life sciences 120 Chemilumenescence detection kits 1962 Chemistry and biochemistry reagents 717 Chemotherapy resistant bone marrow 1210 Chicken antibody for immunoassay 563 Chicken anti-receptor proteins 563 Chicken egg-derived antibodies 1150 Chicken interferon 394 Chimaeric plant virus particles 274 Chimeric bone marrow cell graft 728 Chimeric toxin 1939 Chinese herbal and patent medicines 724 Chinese medical device and technique 311 Chinese medicinal herbs 731 Chinese moxibustion 2925 Chinese traditional medicine Fumigation steam automatic control treatment device 2555 Chipmaker micro spotting technology 2720 Chip-Scanner 547 Chiral Advanced Laser Polarimeter 2168 Chiral compounds 2123 Chiral drug technologies 732 Chiral HPLC columns 733, 746 Chiral molecules 657 Chiral reagents 42 Chiral reagents 2123 Chiral tridimensional network polymer 732 Chirosan oligosaccharides 1549 Chitinase Gene 439 Chitin/chitosan-based products 2840 Cholera vaccine 259 Cholesterol esterase 548 Cholesterol lowering agent 1133 Cholesterol-lowering drug 450 Cholesteryl Ester Transfer Protein (CETP) vaccine 259 Chondroitin sulphate hemin 2006 Chromatographic columns 2567 Chromatographic data analysis software 2765 Chromatographic data validations 1489 Chromatographic-grade reagents 2744 Chromatographic materials and equipment 1827 Chromatographic purification technologies 2044 Chromatography columns 1075, 1083 Chromatography detector 2628

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Chromatography Equipment for drug research 1686 Chromatography media 1075, 1783 Chromatography products 2660 Chromatophic Separator 601 Chromatoplate 1075 Chromogenic and Fluorogenic Substrates 690 Chromoprobe kits 864 Chromatogram Server 1253 Chrysalin for chronic wound healing 747 Chrysosporim enzyme complex 983 Chymase 818 Cialis (Tadalafil) 1016 Cidofovir 1259 Circulating baths and chillers 574 CITADEL® Wafer 1289 Citicoline (for stroke) 1519 CLA allergy test 1767 Class 2 microbiological safety cabinet 1044 Clean air/containment equipment 1044 Clean circulation method 2731 Clean enclosun systems 2545 Clean room air shower 1699 Cleanroom oven number395 2741 Clean rooms 54, 1315 Clean stations 1518 Cleaved caspase-specific antibodies 673 Clenoliximab/IDEC-151 1386 Client-directed combinatorial libraries 719 Clinical assay kit determines efficiency of anticancer drug 1790 Clinical diagnostic agent 388, 1926 Clinical diagnostic drugs 1660 Clinical diagnostics 177 Clinical evaluation of drug 2613 Clinical genomics programs 1166 Clinical laboratory equipment/ diagnostic kits 2072 Clinical Laboratory Inventory Program 890 Clinical laboratory test kits 2629 Clinical-ready bioactive compounds 50 Clinical Systems Network 462 Clinical tests program 1512 Clintrace 958 Clofabine 1248 Cloned gene 1858

Cloned human neuroreceptors 2671 Cloned receptors for drug discovery 2410 Cloneppete 1521 Clone selection and fermentation optimization 1498 Clonetics normal human cell systems 545 Clonezyme 950 Cloning & expression vectors 769 CNS, PNS, and cardiovascular drugs 778 Coagulation monitors 633 Coagulation research reagents 1296 Coagulator 1296 Coated well plates 1874 Coccidiosis vaccine 583 Cockroach Bait 960 CogniMax™ 2665 Cognition enhancers 95 Cognitive testing system 688 CO2 Incubators 2294 CO2 lasers 1684 Cold rooms & freezers 1048 Coliphage Virus test 960 Collagen synthesis inhibitors 1113 Collect cell enrich immunocolumns 881 Colloidal gold conjugates 2517 Colon cancer diagnostic 433 Coloregal Cancer vaccine 2091 Colorimetric High-Density cDNA Microarray Membranes 2829 Colorzyme 1422 Colostrum substitutes 2783 12 column cleavage instrument for DNA 401 Columns-electrochromatography 626 Columns for affinity chromatography 742 Columns for biopurification 779 Columns for HPLC 743 Combichem Synthesizer 2399 Combination cancer therapy 467 Combination swine vaccines 32 Combinatorial antibody library 2549 Combinatorial biology drug 2729 Combinatorial chemistry 597, 1840 Combinatorial chemistry library 941, 997, 1543, 2624 Combinatorial Chemistry Medicinal Chemistry Program 1835

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Keywords Index Combinatorial chemistry products 721 Combinatorial Genetics drug discovery platform technology 2084 Combinatorial libraries 793 Combinatorial medicinal chemical 2287 Combinatorial organic synthesis 2641 Combinatorial synthesis 2581 Combiplates 1019 Combretastatin (CA4P) 2129 Com gluten herbicide 2590 Commercial/ Industrial cleaning equipment 2020 Commercializing functional genomic marker 1097 Commercial scale-up production and purification 2604 Common gamma chain monoclonal antibody blocking agents 386 Compact Digital™ precise stirrer 595 Comparative molecular fieldanalysis 2793 Competitive drugs 2233 Complementary technologies 2680 Complement inhibitor 875 Complete antibodies 1770, 2363 Complete imaging systems 193 Complete Northern analysis kit 116 Complete Robotic Platform 254 Complex for normal human cells plus media and supplements 2780 Complex glycoconjugates 917 Complex organic compounds 2414 Compost Futures for composting technology 2922 Compounds for the treatment of AD 1906 Compounds for the treatment of immune system disorders 2309 Computational genomics 799 Computational model for predicting drug metabolism 616 Computational models for predicting blood-brain barrier penetration 616 Computational models for predicting drug absorption 616 Computational models for predicting drug human intestinal absorption 616 Computer aided biotech medicine analytical software 2512

945

Computer aided devices 796 Computer aided drug design 1545, 1635 Computer aided drug design system 2484 Computer aided pharmaceutical analysis 1212 Computer-automated instruments 1967 Computer based disease simulation systems 1040 Computer hardware & software 102 Computer hardware and software for drug research 1540 Computer hardware/software system 714 Computerized Gas Dilution System 1046 Conditionally immunological transgenic cell lines 1023 Conditioned culture media 2413 Conductivity detector 1615 Confidential lyntotoxin 723 Confocal laser imaging products of gene chips 414 Confocal scanner for microarrays 414 Conjugates and precursors 1123 Conjugate vaccines 1969 Conotoxin peptides 778 Constant temperature equipment 1590 Constant Temperature Equipment for labs 2559 Contact dermatitis 725 Contaminant analyses and safety testing of cell lines 166 Contaminated water management system 519 Context-Independent phospho-antibodies 673 Continuous bio-waste system technology 421 Contract biotech medicines 1478 Contract drug research 1609 Contract R&D drug 2002 Control biokinetic software 472 Controlled Drug release matrix 1553 Controlled environment system 810 Controlled rate freezing system 2797 Controlled release drug delivery system 2192 Controlling insulin releasing devices 637 Conveyors and mixing systems 232 Cooling and heating circulator 1349 Copper therapeutics for wound care 2318 Corlopam 1990 Corn borer plant vaccine 830

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Corn breeding 2253 Corn seed breeding 1713 Coronary bypass graft 440 Corresponding chip reader systems 2953 Corticosteroids 1385 Cortisol-Saliva Elisas 968 Cosmetic coloring agents 852 Cosmetic ingredients 2967 Cosmetic raw material 1827 Cosmetics 959, 1395, 1574 Cotton development monitoring 1274 Coupled amplification and sequencing 484 Coupling Reagent for Solid Phase Peptide Synthesis 1738 Coupling regents 484 Covasheres Reagents 981 C-Reactive Protein 1200 Critical blood analytes systems 734 Critical filtration devices 206 Crop plants breeding 2242 Crop plants for insect resistance 1541 Cross flow absorber devices 1855 Cross-flow filtration 2481 Cross Flow Filtration System 75 Crossflow membrane filters 464 Cross-linked Allophycocyanin 852 Crosslinked hemoglobin 2384 Crosslinking reagents 329, 1903 Cryogenic Chillers 1349 Cryogenic purification devices 153 Cryogenic purification technique 1942 Cryogenic refrigerator 2798 Cryogenic separation devices 2610 Cryogenic storage equipment 2699 Cryogenic tubes 2580 CryoPlates 836 Cryopreservation 928 Cryopreservation technology 2252 Cryoprotector 123 Crystal growth plates 1024 Crystal Growth Robotics 1024 Crystal miniaturized identification system 303 CS Bio Process Development Synthesizer 839 C-TRAK PSA 2394

Cubicin 843 Culture devices 1361 Cultured human epidermal allografts 500 Cultured human epidermal autographs 500 Cultured normal human cell 500 Culture fermentors 2875 Culture Identification Probes 1237 Culture media additive 504, 1195 Culture media ingredients 1310 Cultures of lactic bacteria 1486 Customized AFM probes 377 Customized industrial enzymes 2453 Custom precast gels 514 Cyclodextrins 856 Cyclops 1623 Cymbalta 1016 Cypermethrin 770, 771 Cysteine protease inhibitor 1055 Cytelisa Kits 863 Cytochrome 865 Cytodetec kit 1542 Cytogenetic screening 1423 Cytogenic liquid level controllers 796 Cytohistologic differentical diagnostics 177 Cytokine 863, 1170, 1551 Cytokine assays 2389 Cytokine ELISA 1581 Cytokine ELISA Kits 411, 488, 672, 1509 Cytokine ELISA’s 1426 Cytokine immunoassays 368 Cytokine induced-killer cells 1030, 1552 Cytokine inhibitors 1113 Cytokine kits 1030, 1459, 2472 Cytokine network 448 Cytokine receptor 863,1030, 1551 Cytokines 85, 138, 251, 253, 280, 474, 873, 1243, 1304, 1354, 1360, 1367, 1677, 1927, 1955, 2177, 2178 Cytokines-ELISA kits 2725 Cytokine therapy 863, 1030 Cytokinin 1030 CYTOLIN 869 Cytolyt Solution 884 Cytophilic antibodies 306 Cytoskeletal polypeptides 1724 Cytoskeletal protein 319

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Keywords Index Cytotoxic agent prodrug 2-D analyzer 1229

2721

Data acquisition/analysis software 2301 Data acquisition and analysis software 889 Data acquisition and control software 442 Data Acquisition Software 2240 Data Acquisition System 1852 Data analysis and experimental design software 617 Data analysis systems for drug research 2266 DATA ANALYSIS TOOLS 1182 Database of gene function 1696 Databases & proteomics tools 1217 Data collection software 2694 Data Impressionist 1176 Data loggers 821 Data logging devices 2495 Data management system for large scale DNA sequencing 1982 Data System Validator 277 DCode Cycle Sequencing System 953 3-D Culture 1195 D-dimer diagnostic test kits 517 Decapeptyl 895 Defense equipment 1569 Defined heparins 795 Dehydrated culture media 1303 Dehydroepiandros-terone 1181 2-D electrophoresis drug 1678 Delivery agents components 1028 Delivery system 91 Denatured compounds 243 Denaturing proteins 1242 Dendritic cells 767 Dendritic cell vaccines export system tumor immunomonitoring 534 Dendritophage Therapy 1390 Denosumab (AMG 162) 132 Densitometer 142 DENSPM for anticancer uses 2659 Dental film scanner 2587 Dental X-Ray imager 750 DepoCyt™ 2585 Depo/Therapeutic protein 2585 Depth filter media 1072

947

Dermagraft-Ulcers 46 Dermal Powderject 736 Dermatological anti-inflammatory 875 Dermatological drugs 1240 Dermics 2121 Dermostatin 189 Designed molecular diversity 794 Design technique of peptide immunogens 2181 Detection kits 392 Detection kits for agro-food products 2785 Detection kits of plant pathogenic bacteria 62 Detect Kit 1382 Detergents 522596, 962, 1015, 1155, 1574 Deug design platform 1006 Devices and equipment for cell culture 815 Devices and processes for food waste treatment 1191 Dexketoprofen 736 Dextran serum substitute 918 Dextran sulphate 918 Dextrins 302, 718 2D-gels 1231 Diabetes and rheumatology.therapeutical drugs 1018 Diabetes therapeutics 921 Diacol 1455 Diagen™ research kit 1332 Diagnostic & C/S tests for malaria 1128 Diagnostic agent of infectious disease 496 Diagnostic and therapeutic products 292 Diagnostic assay for Alzheimer’s disease 1906 Diagnostic assays 237, 1925 Diagnostic assays for retrovirus specialized on reverse transcriptase 646 Diagnostic drug 1399 Diagnostic enzymes 1018, 1025, 1119, 1159 Diagnostic kit 173, 334, 709, 927, 1009, 1025, 1119, 1399, 1760, 1828, 2283, 2320, 2616 Diagnostic kits for infectious diseases 1662 Diagnostic kits for swine 1693 Diagnostic kits to detect human diseases 937 Diagnostic/monitoring tests for transplant 1241 Diagnostic reagent of molecular disease 1223 Diagnostic reagents 63, 470, 786, 1018, 1119, 1159, 1780, 1828

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Diagnostics 643, 1504 Diagnostics for diabetes management 1099 Diagnostics for food allergy 931 Diagnostics for human and veterinary disease 931 Diagnostics reagents 923 Diagnostic systems for plant diseases 133 Diagnostic test for paratuberculosis 565 Diagnostic test kits 1477, 1780, 1781, 1961 Diagnostic/treating/preventing drugs for gastrointestinal diseases 1041 Dialysis membranes 1821 Diamond Knives 935 Dietary supplement 1531 Dietary Supplement Cardia Salt Alternative 115 Differential Photometer 215 Differentiation methods of embryonic stem cells 2879 Different intermediates and active ingredients 1727 Different software tools 2128 Difficile toxin/antitoxin testing methods 2707 Digital Image Analysis System 385 Digital imaging systems 102, 1407 Digital Indicators 2439 Digital Spectrophotometer 1661 Digoxigenin labeled probes 2732 Diode Array HPLC Detector 978 Dioxin-Prep Sample Cleanup System 1129 Direct contact steam injection heating 1363 Direct DNA Probes 1237 Discovery CP Analysis 889 Discovery of novel drug candidate 2572 Discovery software of biotech medicines 92 Discovery Vaccines 106 Discrete cell analyzer 1404 Disease-free 830 Disease free grapevine nursery stock 71 Disease genes discovery 989 Disease medical diagnostic kits 118 Dispensers 1298 Disponable syringe 2447 Disposable cell culture device 358 Disposable culture bag 2681 Disposable human sperm isolation kit 1151 Disposable 3mm × 4cm Accuprobes 835

Disposable 384 Pin Replicators 1209 Disposable plastic components 2372 Dissolution Testing Station 2839 Dissolved oxygen measurement systems 1839 Dissolved oxygen sensors 1453 Distillation Apparatus 600 DMF dynamic membrane filters 2142 DNA & peptide synthesizer 2548 DNA & RNA in situ hybridization and detection kits 1645 DNA & RNA modifying enzymes 1117 DNA & RNA sequence analysis 2450 DNA & RNA Synthesis Products and Molecular Biology Kits 825 DNA amplification 782, 1732 DNA Analysis Chip 1401 DNA analysis devices 954 DNA and Motif databases 183 DNA and peptide synthesizer 33 DNA and RNA oligonucleotide synthesis 855 DNA and RNA synthesis reagents 833 DNA-Arrager 1258 DNA Array 1084 DNA-Arrayer 547 DNAase reagents 1265 DNA assay 1561 DNA assembly and analysis program 1173 DNA-based diagnostic platform 2771 DNA based diagnostic reagents 1776 DNA-based testing 704 DNA based ultra sensitive diagnostic kits 712 DNA binding protein 1550, 2815 DNA chips design 799 DNA chips for genotyping/sequencing 225 DNA cloning vector 261, 1325, 1871, 1265 DNA damage detection assays 2788 DNA damaging test 1221 DNA database 188, 2398 DNA deletion test 1221 DNA dependent protein kinase 1196 DNA detection devices 152 DNA detection kits 13, 152, 1265, 1977 DNA detection mapping 1221 DNA diagnostic agents 1219 DNA diagnostic assays 1219

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Keywords Index DNA diagnostic enzymes 1208, 1219 DNA, DNAse, RNAse Contamination Test 1809 DNA drug complex 66, 2367 DNA engineering and gene synthesis technologies 198 DNA extraction kits 833, 1177,1732 DNA extractor 188, 1059, 1550 DNA finger print 975 DNA fish probes 2896 DNA fragment analyzer 188 DNA helicase 1106 DNA integrity assays 1095 DNA Isolation Kit 66, 1242 DNA kits 1009, 1187, 1192, 1779 DNA kits mismatch repair protein 1171 DNA ladders 608 DNA library 254 DNA ligase 1106 DNA ligation & screening kit 1056 DnaLIMS™ 956 DNA mapping/mutant detector 1245 DNA MeTase antisense inhibitors 1835 DNA microarray 1496 DNA microarray bioinformatics software 364 DNA micorarray functional genomic marker 1179 DNA Micro Array Scanners 192 DNA microsatellites for gene mapping 565 DNA modifying enzymes 1196 DNA molecular weight markers 129, 1106 DNA mutation detection kits 1550 DNA Patent Database 1140 DNA polymerase 1117 DNA preparation & storage 1122 DNA primer 518 DNA probe 188, 392 DNA probe assays 1051 DNA probe kits 1222 DNA probe membranes 1981 DNA probes 105, 518, 712, 1051, 1088, 1187, 1269, 1388, 2047, 2883 DNA probes for identification and parentage testing 667 DNA — Probes test kit 1598 DNA Processing System 197 DNA profiling 1697

949

DNA Protector 1282 DNA protein complex 1323 DNA purification kits 99, 188, 392, 518, 1224, 2492 DNA purification reagents 125 DNA purification systems 1001, 2328, 2493 DNA repairs technology 189 DNA repair synthesis 1187, 1619 DNA replication for gene therapy 2419 DNA repository and database 1226 DNA/RNA Automate isolation /Purification Systems 2355 DNA/RNA Builder 242 DNA/RNA custom synthesis 833 DNA/RNA Extra-Sep extraction kit 518 DNA/RNA hybrid 1187 DNA/RNA isolation kits 1776 DNA/RNA labeling and detection reagents 2848 DNA/RNA modifying enzymes 1106 DNA/RNA probe kit 1406 DNA/RNA Purification kits 1246, 1407 DNA, RNA purification kits 1894 DNA/RNA reagents 833 DNA/RNA synthesis reagents 125 DNA/RNA synthesizers 131 DNAscan Automatic Sequencing 2488 DNASCREEN™ 977 DNA screening test for early detection of cancer 1095 Dnase 1 footprinting kits 1682 DNA separation and purification techniques 1885 DNA sequence analysis/comparison 1235 DNA sequence analytical devices 892 DNA sequence analyzer 538, 1323 DNA sequence electroblotter 2122 DNA sequence encoding 535 DNA Sequenceing Analysis 308 DNA Sequencer 184, 244, 308, 892, 999,1871 DNA Sequence Software 1706 DNA sequencing 1326 DNA sequencing kit 1056 DNA Sequencing Reagent 1235 DNA sequencing systems 1144 DNA sequencing technique 2534 DNA sequencing technologies 795

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DNA Sequener 1235 DNA shearing device 1183 DNA size markers 1117 DNA synthesis consumables 2299 DNA synthesis reagents 1121 DNA synthesis technologies 2691 DNA synthesizer 184 DNA synthesizer 244, 392, 1894, 2299 DNA testing 1778 DNA testing program 1323 DNA Test Kit 173 DNA thermal cycler 184, 392 DNA transcriptase 1187 DNA Transilluminator 1139 DNA unwinding protein 2367 DNA vap centrifugal evaporator 1658 DNA variation analysis 484 DNA vectors 287 DNA vectors and markers 1644 DNA vector systems 1895 DNA with modifications 952 Dog contraceptive peptide 2180 Dong E E Jiao 2553 Donor Bovine serum 693 Donor Goat serum 693 Donor horse serum 693 Dopamine beta hydroxylase targeting 44 Dosage controllers; Reaction calorimeters 231 Doublet twist clon Tech 963 DoubleTwist’s Exclusive Annotated Human Gene Index 963 DoubleTwist’s exclusive Annotated Human Genome Database 963 Down-stream processing 1656 Doxorubicin analog 1165 DP-b99 for stroke 966 DP-71 for cancer 966 DP-VPA 966 D-ribosomal protein 369 D-ribosomal RNA 369 Drug against angiogenesis 158 Drug analytical instruments 4 Drug and DNA delivery systems 1503 Drug carriers 178 Drug clinical trial software 24 Drug column chromatography 1563

Drug component detector 325 Drug compound library 2762 Drug construction analysis 2403 Drug delivery PEG products 2558 Drug delivery 182 Drug delivery devices 15, 2473 Drug delivery new systems 1006 Drug delivery platform 980, 1006, 1271, 1745, 2523 Drug delivery route 51, 856, 857, 972, 2015, 2654 Drug delivery system 1146, 1557, 1745, 2212, 2311, 2430, 2951 Drug delivery technique 1956 Drug delivery technologies 110, 2229 Drug delivery technology 663, 1322, 2549, 2748 Drug delivery technology and devices 660 Drug design platform 1006, 2179 Drug design program 856 Drug design software 713 Drug design technologies 2572 Drug design through disjunction 980 Drug design tools 1763 Drug development informatics 2231 Drug development software 1285 Drug discovery 187, 359, 793, 1600, 2043, 2325 Drug discovery/development route 1930 Drug discovery process 698 Drug discovery products 2651 Drug discovery programs 2444 Drug discovery R&D software 1212 Drug discovery route 211, 256, 332, 614, 701, 1054, 1096, 1192, 1271, 2036, 2147, 2241, 2756, 2759 Drug discovery software 713 Drug discovery technologies 2933 Drug discovery technology 971 Drug for CNS 1554 Drug formulation design 857 Drug/gene delivery route 876 Drug information management system 1188 Drug lead devices 1704 Drug metabolic enzymes 367 Drug metabolization enzymes 972 Drug of Abuse test 2686 Drug physicochemical tests 801

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Keywords Index Drug polymer systems 1703 Drug proprietary discovery technology 15 Drug proprietary screening technology 701 Drug R&D plants 2446 Drug research platforms 1247 Drug research tools 2702 Drug-resistance gene 2147 Drug-resistance strain 248, 2267 Drug response assay 175 Drug safety database 889 Drugs against pain 1031 Drugs clinical packaging 2314 Drug screening devices 790 Drug screening instruments 336, 1704 Drug screening program 41, 1054 Drug screening route 248, 1287 Drugs drug discovery route 2743 Drug screening technology 22 Drug separation devices 792 Drug separation technologies 145, 942 Drugs for acute pain 971 Drugs for inflammation 594 Drug sterile process components 298 Drugs to prevent and treat infections diseases 171 Drugs to treat cancer 2155 Drug synthesis and purification devices 2197 Drug target 1189 Drug target discovery technique 1823 Drug targeted to normal genetic variation 2842 Drug target selection 2605 Drug technology transfer 2812 Drug toxicological tests 801 Drug transport 1189 Drybath incubators 559 Dry power media 1589 Ductless fume enclosures 1887 Durus™ for penile impotence 492 Dust Containment Cabinets 2845 Dynabeads Biomagnetic Separation 986 Dynamic Image Analysis System 2594 Dynamic Light Scattering Instruments 2344 Dynamic model of the prostate for Urodynamic obstruction 1722 Dynepotm 2786 Dyslipidemia 107

951

Dystrophin antibodies 1087 Dystrophin test 1221 EasyCount™ System 1419 EBV Blot 1180 Echnology for virus inactivation 1300 Econdary antibodies 2455 EDNA-ELCA DNA Detector 1007 Efficient culture of stem cells 1333 EGF 1733 Egglaying breeding poultry 898 Egg white avidin 1470 EIA Kit for detection of rheumatoid arthritis 1082 Eight biopesticides 1944 EL-2+Superantigen A 2833 Elastose Inhibitor 984 Electric cell-substrate impedance sensing 187 Electric Ovoid-tip Needle 2556 Electrochemical biosensors 1531 Electrochemical instrumens 1156 Electrochemical sensor arrays 1848 Electrode/signal conductioners 27 Electromagnetic field-based drug delivery 1164 Electro-mechanical 969 Electro microscope 2305 Electronic drug application 1979 Electron microscopes 2235 Electrophoresis & Imaging System 2055 Electrophoresis apparatus 1521, 2451 Electrophoresis apparatus systems 208 Electrophoresis chamber 424 Electrophoresis devices 642 Electrophoresis-grade reagents 424, 1749 Electrophoresis systems 1121 Electrophoresis-grade reagent 2485 Electroporation apparatus 1066 Electroporation equipment 876 Electroporation technology 1216 Electroporators 1794 Electrostatic Energy Analyzer 800 Elisa & DNA diagnostic kits 1131 ELISA assays for autoimmune 1131 ELISA assays for breast cancer 1799 ELISA kits 62 ELISA Kits for cancer prognosis 122

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International Complete Collection of R&D Information about TCMM and BT Enterprises

ELISA kits for ENA 1798 ELISA kits for laboratory large scale testing 658 Elisa Kits for QC 858 ELISA screening kits 1980 Elisa test for hepatitis C 1878 Embryo cell cultures 872 Embryonic stem cell 1023 Embryos transfer technique 1674 Embryotech 1023 Embryo transfer media 1381 Emend (Aprepitant) 1826 Emergency medical devices 1829 Encapsulated drug delivery technology 98 Encapsulated drugs 784 Encoding HLA-B7 antigen 2858 Endocrine Disrupter Test 478 Endometriosis Dx test 2315 Endothein receptor polyclonal antibodies 1748 Endothelial Cell Growth Supplement 1118 Endotoxin antibodies 1362 Endotoxin neutralizing protein 1362 Endotoxin Reagents 672 Endotoxin removal devices 226 Endotoxin test kits 545 Engineered antibodies 1566 Engineering bacteria 1566 Engineering cell 1130, 1566 Engineering/Validation/Compliance Consulting systems 2237 Enhanced immunologic function drug 293 Enhanced Red Blood Cells-O2 Deliver 2747 Enhancins 1859 Environmental bioprocess engineering bacteria 1129 Environmental bioremediation 352,1045 Environmental detector 1876 Environmental lean-up kits 2198 Environmentally acceptable technologies 2607 Environmentally sensitive packaging for pipet tips 808 Environmental pollutant Analysis 12 Environmental pollutant detector 278 Environmental pollutant testing equipment 1047 Environmental pollution control devices 1546 Environmental room 278, 1731, 1737 Environmental rooms & chambers 1048

Environ mental walkin chambers 2028 Environmental waste water treatment equipment 1466 Enzymatic acylation agent 79 Enzymatic assay kits 122, 1682 Enzyme 1282 Enzyme additives 950 Enzyme-based nutritional supplements 1965 Enzyme based system for water treatment 2745 Enzyme conjugates 729 Enzyme-containing food material 112 Enzyme drug 1558, 1607 Enzyme expression systems 1353 Enzyme immunoassay kit 2291 Enzyme immunoassays 1082, 1820 Enzyme inhibitor 1558 Enzyme inhibitor complex 1559, 1901, 2540 Enzyme labeled antibodies 1565 Enzyme linked coagulation assay 1007 Enzyme of preventing ageing process 373 Enzyme reactor technology 1175 Enzyme replacement therapy 1052, 1248 Enzymes 374, 402, 435, 447, 466, 470, 476, 515, 520, 525, 650, 678, 727, 739, 865, 926, 946, 1084, 1160, 1374 Enzymes for chemical synthesis and diagnostics 341 Enzymes for diagnostic reagents 112 Enzymes for food 112 Enzymes in plants 2950 Enzyme Stabilizer 1464 Enzyme substrate complex 137, 1273, 1324 Enzyme substrates 504, 507, 1273 Enzyme substrates & inhibitors 282 Enzymetic technique 119, 2060 Enzymic reagents 1125 EPA 1393 Epidermal specific promoter 2038 EpiDNA Picogram Assay 1208 Epifluorescence microscopes 1526 Epitope tag 127 Epitope Tagging 2895 EPO 1197 Epstein-barr virus diagnostic kits 1280 Epstein-Barr virus vaccine 270 Equine IgG 924

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Keywords Index Equine Somatotropin 571 Equipment & accessories for molecular biology research 1139 Equipment for plant tissue culture 2116 Equipment/instrumentation for pharmaceutical research 824 Equipment/instrumentation of biomedical lab 2898 Equipment to automate and increase process efficiencies for drug research 641 ERGOSET 1070 Erwinase 695 Erythropoetin 672 Erythropoietin 1167, 1206 Esoteric clinical tests 2615 Especially protein sequence analysis 1091 Essential nutrients 494 Estradiol/Progestin 2749 Estravail 1414 Ethical pharmaceutical 748 Evaporative Light Scattering Detector 1379, 2441 Excimer laser system 2617 Exendins 140 Exisulind 669 Expansion of hematopoietic stem cells 661 Experience and technologies of R&D 1308 Experimenter’s professional Workbench 889 Exposure Enclosure radiation shield 2467 Expression Analysis Software 1898 Expression/cloning reagents 999 Expression of heterologous multi-domain 185 Extensive line of generic plastic 1270 Extracellular matrix systems for cell culture 675 Extracorporeal liver assist device 2882 Extra corporel immuno adsorption devices 862 Extraction Kit 1804 Extraction resins 818 Extravase 1373 Ex Vivo Liver Assist Device 2010 Ex-vivo T-cell expansion for oncology & infectious diseases 2931 EZ-Screen test kits 1817 Face and Glycosep HPLC 1275 Factor V Gene Mutation Assay 2859

953

Family Kit 1179 Fast Immune Assay Systems 309 Feed additive 897 Feed enzymes 512, 711, 897 Feline leukemia vaccine 204 Feline vaccine 2436 Female healthcare drugs 1720 Femal healthcare program 1720 Fentora 697 Fermentation/cell culture technology 653 Fermentation extracts 1946 Fermentation, Fermentation media from lab to production scale 2809 Fermentation Gas Sensor 788 Fermentation nutrient drug 1759 Fermentation nutrients 1310 Fermentation products for agriculture 2482 Fermentation software 196 Fermented nutrient drug 1680 Fermenter controller 1012 Fermenters 720 Fermenters and reactors 370 Fermenters/Bioreactors 456 Fermentor 458, 1725 Fermentor agitation devices 458, 1158 Fermentor control devices 380 Fermentor controller 1158 Fermentor pump 2903 Fermentors 296, 585, 2248 Fermicidin 1159 Ferritin products 2006 Ferritins 818 Fetal bovine serum 591, 840, 1361 Fetal cell stain kit 2579 Fibrewell molecular separation systems 1144 Fibrin microbeads 1294 Fibrinogen assay 633 Fibrinogen binding moieties 984 Field corn inbreds and hybrids 2242 Film coating technologies for TCMM tablet 1964 Filter 2828 Filter devices for drug research 2912 Filter/Dryer 2643 Filters 1188 Filters for fermentor air 1819 Filtrasil 221

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Filtration equipment 1127 Filtration products for contamination-free drugs 2142 Fine biochemical synthesizer 2539 Fine chemical 380, 567, 1115, 1825, 2201 Fine filter 2622 Fine organic compounds 2224 Fine synthetic organic compounds 1492 Fingerprinter system 38 Fingertight fittings 2819 First Defense 1413 Fish vaccines 887 FITS Assay detection system 1721 Flash Freeze and Enhanced Growth Media 1743 Flaw Savr™ tomato 599 Flexible cell culture media bags 2703 Flexible plastic containers 2638 Flockscreen 1288 FLOCOR 883 Floor model high speed centrifuges 798 Flow cytometer 304, 885, 1102, 1126, 1457 Flow cytometry apparatus 2808 Flow cytometry instruments and software 874 Flow cytometry kit 334 Flow cytometry products 1314 Flow Cytometry System 309 Flow injection analyzer 1595 Flowmeters 1260 Flow-through plate micro-washer 939 FLOW-THRU CHIP TECHNOLOGY 1182 Fluid-based prep system 1917 Fluometer software and hardware 741 Fluorescence in situ hybridization (FISH) buffers 479 Fluorescence kits 1126 Fluorescence Lifetime Spectrometer 2239 Fluorescence polarization plate reader 829 Fluorescence polarization in microplates 555 Fluorescent gel imager 1704 Fluorescent image analyzer 1343, 1344 Fluorescent probes for use on microarrays 1222 Fluorescent substrate labelled immunoassay 2097 Fluorogenic Oligonucleotide Probes 2611 Fluorogenic probes 477 Fluorometric/photometric detector units 147

Flu Vaccine 1538 Fluzone 802 FNG-l Mab (cancer) 2938 Foam separater for fermentation 961 Focht Chamber System 459 Food Allergen Immunoassays 1017 Food Analysis Kits 537 Food composition detector 1213 Food contamination assays 1213 Food diagnostic test kits 2737 Food effective ingredients 2470 Food enzymes 2836 Food ingredients 483 Food microbiology testing technologies 2149 Food processing method 1213 Food processing products 522 Food processing technologies 115 Foodproof salmonella 527 Food Protein Kits 1017 Food supplement 191 Forensic analysis diagnostic testing 578 Forensic and genetic testing 795 Forest encephalitis vaccine 1022 Forest industry by-products 1133 Formaldehyde Generators/Neutralizers 700 Formalin Recycling System 575 Forskolin 1108 γ-fowlpox PSA vaccine 1957 Fragment Analyser 131 Freeze dried biochemical test media 1945 Freeze-dried Gel 639 Freeze dryers 456,1145,1339, 1343, 1731 Freeze Dryers & lyophilizers 1624 Freeze dry systems 1652 Freezers 1764 Freezerworks 890 Fromase 976 Frozen cell trays 1241 Fufang E Jiao syrup 2553 Fufang shiwei tablet 724 Full Length Genes 101 Full line of RIA 1805 Fully human antibody Fab fragments 132 Functional Genomics Factory 1148 Functional genomics system 2288 Functional genomic tools 2763

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Keywords Index Functionalized encapsulate flucrescent nanocrystals 358 Functionally improved enzymes 1094 Functional Meat Proteins 134 Furunculosis vaccine 1868 Fusion protein 1939 Gabitrol 697 Gametocyte 2941 Gas and liquid purification technologies 961 Gas Chromatograph 586 Gas detection instruments 1881 Gas measuring instrumentation 2101 Gastric retention system 908 Gastroenterology peptides 2427 G-CSF receptor 176 GD0039 for treatment of solid tumor 1272 Gel-Pro Analyzer 1795 Gel retardation kits 1179 GEL Software 799 Gel-2-Well-Colony/Plaque picker 1183 GEM® 231 (antisense) 1359 Gene & Protein Discovery 101 Gene-activated proteins 666 GeneAlbum 1438 Gene amplification technology 638, 1039 GeneCAPSULE 1231 Gene code 1190 Gene complex 1909 Gene computing technology software 37 Gene Conechambers 1197 Gene construction 1130 Gene Construction Kit 2 2735 GeneData Expressionist 1176 GeneData GelTools 1176 GeneData WorkBench 1176 Gene Diagnostics 1299 Gene Discovery 1708 Gene discovery technologies 888 Gene discovery using microarrays 2463 Gene display kits reagents for gene expression & analysis 1177 Gene drug 2861 Gene duplication technique 2532 Gene encoding hyaluronan synthase 758 Gene expression profiling 378, 1101

955

Gene-expression software 954 Gene expression suppressor 1880 Gene expression system 387, 1001, 1679, 2672, 2818 Gene Expression Tests 741 Gene finding system for genomic sequences 1982 Gene Flow chambers 1197 GeneGuard System 1122 Gene identification 2474 Gene immunotherapy 735 Gene Jockey II version 2 Operating System 485 GeneKits 2878 Gene map 1190 Gene mapping by in situ hybridization 2521 Genemics research software 275 Gene PrintTM STR 2328 Gene probe 1190, 1187 Gene profiling arrays 1226 Gene pulser® electroporation system 462 Gene quantification services 108 General laboratory equipment 2297 General Purpose Bath/Portable Condensers 1987 General purpose research equipment 197 General-purpose valves 589 General reagents 331, 579 Generation of antibodies 1169 Gene repair therapy 2835 Gene replacement therapy 735 Generic anticancer drug 318 GeneScout 2570 Gene Self-Assembly 1972 Genes indentification for common disease 618 Genesis screen 2879 Gene specific transcription factor 1039 Gene synthesis 141, 1500 Gene synthesis technique 2516 Gene therapeutics 1818 Gene therapy 2876, 1818, 136, 249, 264, 294, 421, 767, 1140, 1148, 1207, 1244, 1527, 1528, 1544, 1672, 1779, 1809, 2298, 2370, 2645, 2693, 2742 Gene therapy for cancer 2697, 2864 Gene therapy for glioma 1234 Gene therapy for sinusitis and cystic fibrosis 2697

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Gene therapy products 2466 Gene therapy products for solid tumours 2125 Gene therapy system 1199 Gene therapy vectors 2846 Genetically engineering antibodies 141 Genetically engineered acellular pertussis vaccine 734 Genetically engineered antibody 1140 Genetically engineered cell culture 927 Genetically engineered plant 67 Genetically engineered vaccines 67 Genetically improved seeds 2911 Genetically improved soybeans 67 Genetically improved tree 1134 Genetically modified cell 1157 Genetically modified hematopoietic cells 1089 Genetically modified plants 285 Genetically modified tumor-targeted bacteria 2864 Genetic analysis software 853, 1228 Genetic Analyzer 188 Genetic-based information tools 1761 Genetic construction in drug biosynthesis 2875 Genetic discovery 853 Genetic disease predisposition testing method 2464 Genetic engineering technologies market research reports 357 Genetic medicine 1140 Genetic monitoring of transgenic and knockout animals 704 Genetic profiling for drug targeting 1212 Genetic recombinant biopharmaceuticals 621 Genetic screening 1212 Genetic susceptibility test 1800 Genetic therapies 618 Genetic Thermal Cycler 1262 Gene-Trak® assays 1213 Gene transcription analysis 484 Gene transduction technique 1212, 1672, 2405 Gene transfer methods 2693 Gene transfer reagent kits 1146 Gene transfer vector 1907 Gene vaccines 1663 Genome systems library screening 1224 Genomica discovery manager 1228

Genomica reference database 1228 Genomic bioformatics 938 Genomic databases 1200,1438 Genomic Discovery Systems 656 Genomic DNA 813, 1001, 1039, 1694, 2027, 2824 Genomic DNA extractor 2693 Genomic fingerprinting 1039, 1694 Genomic library 1739, 1895, 1958, 2424, 2824 Genomic marker 2776 Genomic platform 1739 Genomic/proteomic instruments 1229 Genomics lexicon 1140 Genomic Solutions PAGE mini-gels 2744 Genomics platform 10 Genopattern analyzer 1209 Genosome of biodiversity 2156 Genotyping Chip 1401 Genotyping for identity and parental verification 2464 Genotyping technology 1215 Genzyme 1581 Gerbu Adjuvant 650 G207 for CNS Tumors 1998 GI drug 1384 Glass & plastic environmental sampling containers 991 Glass and plastic packaging products 76 Glassware washer 1875 Glial Growth Factor 2 613 Gliatest 931 GLLADEL® to treat brain cancer 1289 Glove Boxes 521 Glucarpidase (voraxaze) 2349 Glucocerebrosidase 831 Glycemic control in patients 140 Glycoconjugation of peptides and factor 8 1985 Glycoprotein synthesizer 1935 Glylorin 663 GM-CSF Antagonist-E21R 571 GMK vaccine 2322 GMP-grade peptides 1940 GMP-grade product for clinical applications 283 GMP Labels 1276 GMPrint Software 1276 Goat antichicken polyclonal AB 2145

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Keywords Index Goat anti-nitrotyrosine antibody 14 Goat antisera/antibodies 1514 Goat Polyclonal antiserum 627 GPC-Prep Sample Cleanup System 1129 Gp100 DNA plasmid vaccine vector 2285 G protein subunits 482 Gradiflow large-scale separation process 1279 Graft for mismatched bone marrow transplants 728 Granular Silica 1147 Graphite Furnace Atomic Absorption Spectrophotometer 586 Grease-trap waste treatment process 1191 Greenhouse Parallel Synthesiser 2393 Grinfol 1443 Group B Streptococcus vaccines 345 Growth enhancement media supplement 1877 Growth enhancement technology 2190 Growth Factor Antibodies 863 Growth factor receptors 251 Growth factors 1284, 2307 Growth Hormone Releasing Peptide 1594 Growth media 642 Growth-promoting agent 1284 Guaranteed Oligos 1238 Guizhi Fuling capsule 1580 Gumboro vaccine 1533 Haemo-Sol detergents 1297 Halofuginone 785 Handheld microplate immunoassay washer 2396 Hanta-virus 694 Harkoseride 1307 Hazardous-Air Filtration system 700 HbsAg rapid test 1153 HBV PCR Quantitative Kit 1687 HBV Quantitative PCR Kit 2554 HBV vaccine 1698 H19 cancer gene therapy 2158 HCG Product line 1925 HCVblot 1180 HCV inhibitors 2573 HCV Quantitative PCR Kit 2554 HCV rapid test 1153 HCV Vaccine; natural type proteins 1698 HDL cholesterol test 1053

Headspace Autosampler Apparatus 224 Healthcare drug 2645 Healthcare drugs 1085, 1976 Healthcare market information 310 Health care medicine 1085, 1417, 1802 Healthcare nutrient drug 1000 Health care products 1802 Healthcare products for the aquaculture 933 Health foods 1971 Health nutriceuticals 916 Heat exchangers for the biotech 2033 Heat-homogeneous DNA probe assay 864 Heat sensitive enzymes for research use 982 Helicobacter pylori vaccine 1093 Hematopoietic progenitors 2262 Hemoglobin solution 294 Heparanase neutralizing monoclonal antibodies 1473 Heparan sulfate derivatives 686 Heparin antagonists 795 Heparin derivatives 1921 Heparin Medium 1783 Hepatitis A Vaccine 121 Hepatitis B DNA vaccine 2285 Hepatitis B vaccine 274, 523 Hepatitis B virus diagnostic kit 1733 Hepatitis B virus pre-S surface antigen 1733 Hepatitis C vaccine 1415, 1733 Hepatitis-C. Virus detection 1539 Hepatitis C virus vaccine 1369 Hepatitis E virus vaccine 1181 HepatoScreen™ Test Kit 1353 Hep C therapy 387 Hep I for therapeutic 1372 Heptatitis B immune globulin 622 Herapeutics for heart disease 157 Herbal extracts 901 Herbicide resistant corn 898 Herceptin® trastuzumab 1186 Herpes 8 2639 Herpes-2 therapeutics 249 Herpes vaccines 1838 HESC Media 1534 Hetacool 536 Heterobifunctional crosslinkers 135 Hexten™ 536

957

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HGH 622 H-HGF 2487 High advanced carbon fiber rotors 798 High affinity therapeutic monoclonal antibodies 1410 High density frozen cell concentrates 927 High density growth media 391 High efficiency gene transfer 3 High efficiency transfection 1216 Highest quality biochemical analysis tools 473 High loading support for solid phase DNA synthesis 1715 Highly efficient periplasmatic expression of recombinant proteins 539 Highly purified human plasma proteins 237 Highly-purified natural mixtures of type 1 interferon 2865 High performance affinity products 452 High performance chromatography silica for analytical to industrial scale 1004 High-performance genetic data 2152 High performance proteins and enzymes 2353 High Performance SE-media 1469 High performance ultrafilter 1262 High potency compounds 723 High precision multi-channel dispensing 1227 High pressure cell system 1556 High pressure liquid chromatography 1631 High pressure pumps 199 High protein animal feed ingredient 911 High purity and low water solvents 99 High-purity bovine immoglobulins 134 High purity cesium metal powders 2844 High-purity crude peptides 2345 High purity lipopeptides 843 High purity rapid DNA (from whole blood) separations systems 1144 High Purity Solvent Recycling System 575 High purity specialty chemicals 243 High quality antibodies 2543 High quality biopharmaceutical 1596 High quality cell/tissue culture 2767 High quality hematopoietic culture media 2640 High quality pharmaceutical 2206 High-quality plant latex 1856 High quality radiochemical 128

High quality research biochemicals 648 High quality stainless steel ware 1586 High quality ultrapure water equipment 2841 High-rate biological filter 200 High Rate Compact Reactor 532 High resolution imaging diagnostics 2673 High sensitivity antibodies 6 High sensitivity/high throughput instruments 1843 High shear mixers 2578 High specific activity RNA probes 116 High-speed centrifuges 640 High speed centrifuges for benchtop 640 High speed computational genomics servers 2766 High speed filling equipment for cleanroom 2770 High-speed gene sequencing 475 High speed refrigerated centrifuges 1636 High technology parenteral drug delivery systems 2662 High throughout drug screening 997 High throughput calorimeters 1851 High throughput cell-based screens 2933 High throughput device 1595 High throughput DNA/PCR purification products 1001 High throughput DNA (plant) extraction system 2469 High through-put DNA sequencing 66 High throughput DNA synthesizer 401 High throughput drug screening 602, 1707, 2516, 2624 High Throughput Drug Screening Systems 2131 High throughput gene trapping technology 1696 High throughput isolation tests 1744 High throughput LC 1712 High throughput LC-TLS sample Processor 1689 High throughput molecular screening methods 377 High throughput organic synthesis 794 High throughput plant tissue handling system 2469 High throughput plate systems 1222 High throughput screening 1179, 1941

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Keywords Index High throughput screening and purity testing 1195 High throughput screening assay 268, 1910 High throughput screening devices 1996 High throughput screening system 19 High throughput SNP genotyping 2364 High-throughput Surveyor Mutation Detection Kit 2784 High yielding sugarcane seed 830 High yield transcription kits 1056 H-IL-12 2487 Histaglobine 335 Histochemistry reagents 1606 Hi tech seeds 1316 HIV antigens 2867 HIV gpl20-CD4 drug discovery system 2322 HIV-kits 139 HIV-neutralizing antibodies 139, 1369, 1525 HIV Phenotypic drug susceptibility assay 2868 HIV protease inhibitor 1698, 2852 HIV Rapid Test 307 HIV targeted ribozymes 2255 HIV-1 test using urine as sample 1162 HIV-2 Western blot 1180 HLA antibody 2692 HLA-B27 Gene Detection Assay 2859 HLA tissue typing trays 1241 HMG ELISA/anti-HMG ELISA 1798 Hollow fiber cell culture 2811 Hollow fiber membranes 2139 Hollow fibre peek microfilters 1083 Home Access HIV Home Test Kit 1122 Home healthcare equipment 1829 Homogenisers 199 Homogenizer 574, 1264 Hormone receptor 1600 Hormone Replacement 2046 Hormones 373 Hot plate shakers 995 Hot shakers & hybridization ovens 317 Howeko oral liquid 725 HP 228 2787 HPLC columns 626, 936, 1298, 2234, 2456 HPLC columns for biotechnology medicines research 2268 HPLC Detector 978

959

HPLC-grade reagents 321, 1073, 1366, 1582 HPLC-grade solvent 1073, 1582 HPLC gradient pump 1010 HPLC Low Pressure Gradient Controller 277 HPLC Management software 978 HPLC Radio-Detector 321 HPV1&2 rapid test 1153 HPV peptides 1082 HPV vaccines 1826, 2810 H. Pylori vaccine 2184 HRP conjugate stabilizer 581 HSV vector 583 H-TGF 2487 HTLV-I/II ELBA 1180 HTS system for drug discovery 2762 HTV-1 Urine EIA Diagnostic Kit 606 HTV vaccine 2813 HuC242-DMI 1425 Human & animal chromosome 1102 Human and veterinary diagnostic tests 840 Human and veterinary vaccines 840 Human antioxidant defense system 2150 Human apolipoproteins 1514 Human beta and gamma interferons 1733 Human biomaterials 2215 Human BNP 2508 Human bone marrow cells 94 Human cancer/tumor markers 2517 Human cDNA 463 Human cell culture 813 Human cell transplant 666 Human derived, serum-free, IgG-free serurn substitute 1137 Human derived serum substitute 1501 Human diagnostic antigen 2887 Human ELBA Kit 737 Human genes 1378 Human genome 1378 Human genome mapping technology 1743 Human genomic recombinant antibody libraries 919 Human growth hormone 93, 524 Human healthcare drug 2812, 2949 Human hepatocytes 920, 922 Human IL-1b precursor polyclonal antibody 751 Human IL-lb and IL-6 ELISA kits 751

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Human immunological cells 94 Human insulin of recombinant DNA origin 1016 Humanized anti-CD3 monoclonal antibody 583 Humanized RSV Mab 1811 Human lactoferrin 2228 Human leucocyte markers 1087 HumanLinkage-12 Genotyping BeadChip 1401 Human lipoprotein-associated coagulation inhibitor 14 Human liver microsomes 1353 Human male fertility diagnostic device 155 Human monoclonal antibodies 11, 666, 971, 1236 Human monoclonal anti-HIV-1 antibodies 354 Human neuropeptide receptor 1354 Human neutralizing antibodies 1113 Human osteopontin EIA kit 1420 Human primary cell culture 94 Human protein market of breast 451 Human proteins 837 Human Proteome Survey Database 2346 Human recombinant antigens 1629 Human retroviral diagnostics 2952 Human Sera 1508 Human superoxide dismutase 524 Human therapeutic proteins 2668 Human Thrombin 1296 Human tissue bank 1708 Human tissue culture 1963 Human tissue extracts 2964 Human Transferrin 1137 Human tumor bearing animal model 175 Human tumor necrosis factor receptor 1354 Human tumor vaccines 251 Human urine derived product 1345 Human urine derived protein 1345 Hyaluronic acid derivatives 784 Hybrid antibody 56, 279, 543 Hybrid artificial organs 2746 Hybrid breeding swine 898 Hybrid Capture System 937 Hybrid corn 898 Hybridization-Grade Reagents 937 Hybridisation equipment 1358 Hybridization apparatus 1755 Hybridization ovens 821

Hybrid Kidney failure models 1201 Hybridoma and trans-fectoma technology 803 Hybridoma cell lines 209 Hybridoma culture medium 129 Hybrid Poplars 1134 Hybrid seed of greenhouse tomatoes 1316 Hybrid selection crops 262 Hybrid strain 872 Hybrid vigor screening techniques 509 Hybrid wheat varieties 619 Hybrodoma medium 664 Hybrid antibodies 306 Hydrogel wound dressing 639 Hydroheater 1363 Hydrophobic PVDF membrane filters 1819 Hydroxamate 697 Hylagel 407 Hypothermic solutions 835 Ideal instruments 1980 IDEC-Y2B8 1386 Identification of new receptors 1090 Identification technique of human etiologic agents 1079 Identity kits and hybridization kits 1702 IDS systems 1456 Iduronidase 831 IGF for diabetic neuropathy 247 IGF-I Gene Medicine 1184 IgY purification kit 1150 IL-2 620, 1360 IL-6 1360, 1406 IL-201 1515 IL-3 for gene therapy 1527 IL-2 Gene Medicine 1184 IL-LUMA TOOL tunable lighting system 1711 IlluminaConnect 1401 IL-5 receptor 59 IL-1 receptor delivery system 1454 Image analysis software for life sciences 2024 Image Analysis System 1035 Image analyzed microscopy 2830 Image analyzers 1404 Image capture technology 993 Image data management and analytic system 2880

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Keywords Index Imaged capillary electrophoresis system 809 Image detection hardware and software 225 Image plate detector 1913 Image processing and analysis system 1692 Image signal processing systems 1035 ImageSpace Software 1905 Imaging densitometer 1402 Imaging fluorimeter 1402 Imaging hardware & software for pharmaceutical research 1060 Imaging instruments 1683 Imaging Scanner 469 Imaging system for in situ hybridization 2382 Immobilized enzyme reactors 1442 Immobilized enzymes 483 Immobilized reagents 772 Immobilizer preactivated microplates 1098 ImmTher 1032 Immucothel 501 Immune-based therapy for multiple myeloma 904 Immune regulation molecules 151 Immune stimulants 2856 Immunoassay 1 Immuno assay kit 1076, 2165 Immunoassay platform 2023 Immunoassay reagents 1388, 1421, 1597 Immunoassays 828 Immunoassays for R&D and clinical 968 Immunoassay stabilizer 581 Immunoassay test kits 2647 Immunoboost K 2856 Immunochemicals 430, 487 Immunochemistry reagents 1816 Immuno chromatographic diagnostic kits 805 Immunoconjugate 1348 Immunocyanine 501 Immunodetection kits 83, 1873 Immuno detection reagent 13 Immunodiagnositc test kits 930 Immunodiagnostic 777 Immunodiagnostic kit 486, 1849, 2740 Immunodiagnostic kits for infectious diseases 658 Immunodiagnostic products 529 Immunodiagnostic reagents 379, 486

961

Immunofluor 351 Immunogenic peptides 2966 Immunoglobulins subclasses 438 Immunoglobulins 1596 Immunoglubulin Inhibiting Reagent 463 Immunogold reagents 295 Immunogold staining kits 1511 Immunoliposome 1914 Immunological adjuvant 1423 Immunological disease 594 Immunological enhancement agents 2159 Immunological reagents 603 Immunology 529 Immunomodulator 204, 645, 657 Immunomodulatory plant drug 178 Immunomodulatory/stimulatory adjuvants 1132 Immunopotentiating drug 293 Immunoprevention & immunotherapy of cancer 1750 Immunoreagents 383, 925 Immunoregulators 1813 Immunostainer 1121 Immunotherapeutics 338, 900 Immunotherapy for AIDS 1805 Immunotoxin 1348 Immunoturbidimetric Urinary Albumin Kit 929 ImmunoGold labeled antibodies 1565 Immunomodifier 2732 Imogarn 802 Imovax ID 802 Implantation graft 440 Improved formats for rapid & sensitive DNA/RNA testing 977 Improved healthcare drug 736 Improved yeast strains 1233 Inactives Universal PLAS+SD 2885 Inbred strain 872 Incubator 708, 1571, 1657 Incubators and germinators 810 Incubator shakers 29, 995 Individual cord blood banking 2884 Indoxyl-Glucuronide 1273 Inducer 504 Industrial enzymes 114, 1185, 2048, 2448 Industrial enzymes biological expression system 983

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Industrial enzymes in plants 2258 Industrial Grade Gloves 1856 Industrial HEPA/ULPA vacuum cleaners 2019 Industrializing gene function discovery technology 2154 Industrial proteins 522 Industrial waste water treatment system 28 Inert plastic precision devices 2081 Inert solenoid operated valves and pumps 347 InfectionScreen 1148 Infectious Disease ELISA & Rapid Test 762 Infectious diseases diagnostic test kits 517 Infectious diseases therapeutics 2872 Infectious/hazardous material shippers 2371 Infectious Waste Handling Systems 2442 Infergen 132 Influenza neuraminidase inhibitors 359 Influenza rHAO vaccines 2343 Influenza vaccines 310 Influenza virus vaccine 270, 511 Infrared Spectrophotometer 586 Infrared thermometer 902 Inhaled Rapid Acting Insulin 2375 Inhibin tests for cancer 513 Inhibiting carcinogenesis agents 1058 Inhibitors for cancer 1278 Inhibitors of cGMP-dependent protein kinase 399 Inhibitors specific for apoptosis 1055 In-home water testing kits 1047 Injectable anticoagulant 820 Injectable cell-culture 345 Injectable controlled-release formulations 895 In-line Precalibrated Sensors 2505 Innovative instruments 809 Innovative pharmaceutical 945 Innovative pharmacoinformatic and chemoinformatic technologies 698 Innovative products 2791 Innovative technologies for drug discovery 2286, 2288 Inoculant 512 Insect cell culture 1442 Insect cell culture products 1796 Insect Growth Regulators 960 Insecticidal virus 830

Insect-killing baculoviruses 508 Insect kits 1042 Insect repellent 1042 Insect repellent cream 1142 Insect spray 1042 Insect trap 1302 In-situ bioremediation technologies 1250 In situ chromosome localization 484 In-situ fermenters 1012 In situ hybridization assays 2381 In situ hybridization/detection kit 1776 In situ hybridization products 1314 In Situ Treatment 542 Instant Confirm 1148 InstantScreen 1148 Instrument automation for High Throughput Screening 651 Instruments/apparatus/chemicals for drug research 1121 Instruments/equipment 572 Instruments for a wide variety 2077 Instruments for drug analysis 1631 Instruments for drug research 2960 Instruments for early detection of cancer 1814 Instruments for intracellular research 2923 Instruments for nucleic acid sequencing 1490 Insulating shipping containers 2260 Insulin-like growth-factor 1186 Insulin-like growth factor analogs 1284 Insulin-like growth factor binding proteins 1284 Insulinotropin 2050 Insulin pulmonary delivery system 1454 Integrated Drug Development system 2440 Integrated drug discovery route 1716 Integrated microfluidic systems 1291 Integrated platform of genomics-based technologies 2356 Integrated Reaction Chemistry Cassettes 429 Integrated systems of microplate processing 651 Intelligence design software 1624 Intelligent Automation equipment 1141 Intelligent Automated Fractionator 600 Intelligent Pollution Prevention System 442 Intelligent quantifier 1229 Intelligent Software Tools 1630 Interferon alfa-2a 1167

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Keywords Index Interferon alfa-2b 1167 Interleukin 2 1167 Interlukin-5-IL5 571 Intermediate-based aminoacyl-tRNA synthetase inhibitors 843 Intermediates for DNA 1918 Interrelated gene expression databases 1182 Intradermal multiple injection device 969 Intradermal Tat (MIT) for detection of early cancer 1750 Intron A alpha-IFN 386 Inventory management software 836 In vitro assays 1784 In vitro diagnostic assays for pregnancy 2956 In vitro diagnostic kits 2918 In vitro diagnostic regagents 307 In vitro diagnostic test kits 1646 In vitro fertilization products 682 In vitro liposome delivery systems 2032 In vitro RNA transcription methods 116 In vitro single stranded DNA and preparation kit 1973 In vitro test for DSP in shellfish 478 In vitro test for microcystein in drinking water immuno diagnostic kits 478 In vitro toxicology testing 1287, 1535 In vitro toxicology testing method 968, 991, 1102, 1387, 1400, 1665, 2550 In vitro toxicology testing products 78, 763 In vitro toxicology testing reagents 1291 In vitro toxicology test kits 1774 In vivo brain microdialysis 1784 In vivo gene delivery 1886 In Vivo Multispectral Imaging System 1634 Ion Analyzer 1576 Ion-Exchange Separator 601 Ion Mobility Spectrometers 2167 Ion-selective electrodes 1465 Iontophoresis 1164 IPL423 1447 IPL576 1447 IPLEX 1474 Iquid reagents for research 168 I-Recombinant human heparanase 1473 Iron chelator 413 Iron oxide pigments 449

963

ISIS 2105 1548 ISIS 2503, 3521, 5132, 1548 ISIS 113715 1548 ISIS 3011012 1548 Isis-SGLT zrx 1578 Isogenomics Database 1166 Isolating cells expressing secreted proteins 2407 Isolation/characterization of circulating cancer cells 680 Isolation of fetal cells 1125 Iupo-test Lupus anticoagulant assay 1279 IVF workstation 671 J&J/GR system 908 Japanese Encephalitis vaccine 2100, 2184 Jia Qing Bazhen (eight precious ingredients medicated) wine 1482 Jia Qing cold cream 1482 Jintangning capsule 2958 K252a and derivatives 1108 Keratinocyte growth factor-2 1354 Key biochemical intermediates 2584 Key therapeutic drug 2642 Kg scale peptide synthesizer 838 Kit for animal fingerprinting 1617 Kit for ex vivo expansion of hemopoietic stem cells 1152 Kit for the preparation nofetumomal merpentan 1984 Kits for diagnostic 435 Kits for immune function testing and cell mediated immunity 859 Kits for plant genome fingerprinting 1617 Kits for veterinary viral detection 2687 Kleenedge 2847 Klerzyme 976 Knockout breeding animal 356 Kunecatechins 1808 Kuvan (sapropterin dihydrochloride) 404 Lab and Pilot Freeze Dryers 1351 Lab automation systems and peripherals 832 Lab cell separator 670 Labeled peptides 1084 Labeled secondary antibodies 1880

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Lab equipment for biotech drug research 169 Lab-on-a-chip system 602 Laboratory apparatus 2278 Laboratory apparatus for biotechnology laboratory 766 Laboratory automation instruments 1655 Laboratory automation software 1666 Laboratory biomedical equipment 1003 Laboratory biomedical novel instruments/equipment 1320 Laboratory container 992 Laboratory data-information management systems 2468 Laboratory devices 1543 Laboratory diagnostic reagents 1029 Laboratory disposable plastics 1019 Laboratory drug information management system 1103 Laboratory drug information management system 1174 Laboratory drug information management systems 1339 Laboratory drug screening devices 2449 Laboratory enzyme bacterial testing methods 2057 Laboratory equipment 1254, 1320, 2132 Laboratory equipment for drug research use 474 Laboratory equipment information management system 994 Laboratory equipment/instruments/reagents 2893 Laboratory fine chemicals 709 Laboratory glassware 1510 Laboratory/industrial freezers 2906 Laboratory information/management system 2510 Laboratory Information Management System 2719 Laboratory instruments 1283 Laboratory instruments/equipments of drug research 1021 Laboratory microwave ovens 1013 Laboratory ovens 2921 Laboratory professional equipment 1654, 1892, 2620 Laboratory professional equipment for drug research 781

Laboratory professional instrumentation 314 Laboratory professional instruments 1260, 1653 Laboratory professional reagents 1303 Laboratory reagents 45 Laboratory reagents 1103, 2477 Laboratory reagents grade water purification systems 2599 Laboratory research immunoassays 2390 Laboratory research instruments 2282 Laboratory research novel detection equipment 2195 Laboratory research software 16 Laboratory scale purification devices 994, 1003, 1020, 1120, 1188, 1635, 1648, 1754, 2395, 2500 LAB/Probe® kit detection systems 410 Lab reagents 716 Lab-scale 510 Lab-scale freeze dryers 2874 Lab separation system 696 Labware washer 1676 Lactoferrin 64, 480 Lactoperoxidase 480 Lactopontin 480 Lactotransferrin 480 Laminar airflow equipment 2053 Laminar Flow Biological Safety Cabinets 521, 2359 Laminar flow cabinets 1857 Laminar flow equipment 1044 Lamivudine 345 L-Antibody purification 649 Laboratory scale purification devices 1339 Laboratory scale-up purification devices 1391 Large precast gels 1591 Larger capacity homogenizers 266 Larger fully automated bioreactors 217 Larger variety of vegetable varieties 2524 Large-scale DNA synthesis 562 Large scale fermentation processes 1109 Large scale media 668 Large scale peptide synthesis mehod 2181 Large-scale plasmid preparations 34 Large scale preparation for fermentation 1109 Large scale process control workstations 2530

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Keywords Index Large-scale recombinant adeno-associated virus 269 Large scale separations 2030 Larvacide/adultacide 1471 Lasergene 954 Laser light scatter 2292 Laser microprobe 1684, 2497 Laser projectors for drug industries 2873 LaserScissors 671 LaserTweezers® 671 Lasette finger perforator 671 Latex Pregnancy Kit 929 Latex protein testing 514 LC/MS solvents 1752 Lead compounds 2586 Lead compounds for novel medicines 970 Lead drug MOR 103 2924 Lead drug product 945 Leads Database 799 Lead seeking chemistry library 698 Lectin affinity chromatography 417 Lectin analysis kit 417 Legume inoculants 1717 Lenalidomide (Revimid) 657 Leptin 968 Letairis (ambrisenta) 1259 Leucotropin 622 Leucotropin™ 621 Leukarrest 1380 Leukine 1418 Leukocyte modulators 625 LevemirInsulin detemir 2049 Levocamitine 2571 Library of carbohydrate combinatorial chemistry compounds 2679 Library screening kits 950 Life cell culture system 294 Life codes Microarray system 1702 Life sciences related products 582 Ligand Pharmaceuticals 1785 Ligand-receptor interaction detection system 1220 Lightlycler 527 Light scattering equipment 576 Link Mapper 1228 Lipid Biochemicals 913

965

Lipod complexes 1077 Lipids for biomedical research and food/agriculture research 1718 Lipopolysaccharide binding protein 226 Lipoprotein 1719 Lipoprotein fractionation system 2947 Lipoproteins 2597 Liposomal doxorubicin 1719 Liposomal Paditaxel 2243 Liposomao drug delivery system 1033 Liposome 783 Liposome encapsulated allergens 97 Lipotropin 1719 Liquid chromatography 1344 Liquid Chromatography Columns 2234 Liquid chromatography systems 1261 Liquid crystal filter 829 Liquid handling devices 1258 Liquid handling instruments 1573, 1773, 2582 Liquid Handling Plate 782 Liquid handling products for drug research laboratories 389 Liquid inoculant 1717 Liquid-liguid chromatography instruments 1010 Liquid sterilizing and clarifying filters 961 Liuwei Dihuang pill 2899 Live cell microobservation system 459 Live culture of human & veterinary fungal pathogens 2804 Liver cell clone 1582, 1583 Livestock cloning 850 LM-CD45 for prevention of graft rejection 625 Locked nucleic acid 1098 Logging thermocouple 902 Long-Acting Acyclovir 1124 Long-Acting Insulin 1124 Long-acting interferon 1124 Long-chains fatty alcohols 1993 Long PCR Enzyme 953 Long peptides 505, 506 Loteprednol Etabonate 2229 Low cost production system 185 Low cost sets of unpurified peptides 1883 Low-density biochips 312 Low dose oral interferon alpha 113

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Low endotoxin bovine albumin 1381 Low endotoxin fetal bovine serum 624 Low Light Imaging System 321 Low molecular weight Chondrotin 2935 Low molecular weight heparins 686 Low-pressure chromatography 550 Low-pressure homogenizers 266 Low-rise pesticides 2690 Low temperature freezers 879 Low temperature heated plates 2415 Low Temperature Module 1262 Low temperature storage devices 1942 Lubricious coating 230 Lucentis 1186 Luciferase reporter gene assays 1668 Luminescence Counter for drug screening 2194 Luminomete 222 Luminometer 632, 2800 Lung cancer gene 866 Lung cancer MAb 866 Lycopene 1107 Lyme antibody capture test 1221 Lyme disease vaccine 2588 Lyme Immunoblots 1660 Lyme Immunosis & Western Blot Kits 1417 Lympholyte™ 654 Lymphometer for measuring swelling 1125 Lyophilized culture 1135 Lyphomune 924 Lysozyme derivatives 1929 Mab’s 974 MAb to HBV and HCV 2939 Mac DNAsis Software 1900 Macromolecular crystallographic structure 1024 Macro molecular ligand 7 Macromolecule products 7 MAG/GMI autoantibody test 1221 Magnetically guided carboferro nanoparticles 1747 Magnetic cell separation systems 2007, 1882 Magnetic ceramic particle 1389 Magnetic messenger labeling systems 1071 Magnetic messenger labeling technology 1071 Magnetic particles 759 Magnetic particles separators for diagnostics 759

Magnetic resonance imaging contrast agent 413 Magnetic separation instruments 2576 Magnetic separation of lipoproteins 2412 Magnetizable resins 818 Maize germplasm 2657 Major facility examples 1785 Malaria antigens 1415 Malaria vaccine 1415, 2588 MALDI-TOF 2199 Mammalian artificial chromosomes 745 Mammalian cell culture 558, 675 Mammalian cell derived products 371 Mammalian cell derived proteins 2308 Mammalian cloning 850 Mammalian gene expression systems 1726 Mammalian protein expression systems 1001 Mammallian culture support 2116 Manual multi-channel liquid handling devices 1227 Manufacturing-scale peptide synthesizer 838 Marine biotech medicines 1267 Marine Collagens 1267 Marine food 1555 Marine lipid concentrate 203, 1267 Marine medicinals 1555, 2520 Marine natural products 598 Marine nutraceutical raw material 203 Marine nutraleutical extracts 203 Marine rnicroorganisms 182 Marker Assisted Selection/backeross 656 Markers for the prostate and ovary cancer 2837 Marketing pesticides 508 Market research program 2238 Mass spectrometer 1014 Mass spectrometer of pharmaceutical research 1860 Materials available from analytical to process scale 2894 Mathematical and statistical analysis and modeling software 752 Maxamine 1777 Measurements equipment for drug components 2075 Measuring instruments 1766 Mechanical vacuum pumps 1351 Media filtration devices 1203

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Keywords Index Media for microbiology and biotechnology 579 Media Squares 2916 Medical and research immunoassay kits 587 Medical device disective 899 Medical devices 816 Medical diagnostic kits 86, 1018 Medical diagnostic reagents 1318 Medical imaging instruments 2054 Medical imaging regulatory system 390 Medically important oligosaccharides 2890 Medical sanitary equipment 1143 Medical tubing extrusion systems 1107 Medicinal healthcare products 1000 Medicinal plant cultivation 1483 Medinformatx software 2881 Medusa 1124 Megabase cloning system 2929 Megaextractor 1227 Melacine® melanoma theraccine 814 Melanoma genetic test 1949 Melanoma MAb 866 Melanoma theraccine 2437, 2491 Melanoma vaccine 257 Melting point apparatus and fat extractor 574 Memantine 1991 Membrane based bioseparation devices 2062 Membrane bioreactors 1045 Membrane filter bioreactor 1822 Membrane Filtration Equipment 797 Membrane filtration material systems 1819 Membrane membrane separation systems 1633 Membranes expressing SPCR 1090 Membrane transporter protein 2601 Menotropin 492 Metabolic modeling software 445 Metabolic myopathy tests 1221 Metallopeptidase 418 Metalloprotease inhibitor 677 Metering pumps 1252 Method and model for hair pigmentation 175 Method for preparing cellular fibronectin 1112 Methods for characterizing mRNA molecules 378 Methods for cloning 2003 Methods for detertion of nucleic acid polymorphism 2834

967

Methods for inhibiting tumors 2317 Methods of modifying eukaryotic cells 2407 Methods of therapy with thrombin derived peptides 2113 Method system for genotyping 853 Metrohm titration systems 574 Metronidazole Hydrogel Pessary 687 MGluRs 1396 5 mg to 50 mg bench top peptide synthesizer 838 MHC antigens 2542 Miconazole pessary 583 Microalbumin Test Kits 929 Microalgae biomass 1976 Micro algae separator device 2529 Microarray analysis 1681 Microarray analysis software 2137 Microarray data mining tools 364 Microarrayer 1183, 1209, 2831 Microarray printer 2934 Microarray Scanner 192 Microarrays for genotyping 1226 Micro Array Spotters 1655 Micro-bead DNA technology 2726 Microbial air monitoring devices 531 Microbial Air Samplers 2000 Microbial biocontrol agents 1461 Microbial cell disruption 182 Microbial control agent 339 Microbial databases 1845 Microbial feed additive 2059 Microbial Indentification/Characterization System 398 Microbial pesticides 2499 Microbial screening assay 2376 Microbial sensor 1841 Microbicide 503 Microbiological safety-cabinets 1612 Microbiology culture media 1389 Microbiology testing system 1517 Microbore and capillary HPLC columns 1867 Microbotanica 1850 Microcalorimeters 1851 Microcarriers 668, 2187 Microcentrifuge 907, 608 Microchip-enhanced detection system 1462 Microcyte Flow Cytometer 9

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Micro-Deck Filter Cartridge 1072 Microdialysis probes 1311 Microdialysis Sampling Devices 330 Microelectronics water 2919 Microencapsulated agricultural products 450 Microencapsulated drugs 22 Microenvironmental Sensors 162 Microfiltration apparatus 1633, 1160 Microfluidic dispense/aspiration platforms 641 Microfluidic systems 2103 Microfluidin Research Kit 1862 Microfluor 844, 988 Microfraction in LC and LC/MS 942 MicroFuge 1863 Microgels electrophoresis precast gels 1279 Microgrid 468 Micro Hammer Cutter Mill comminution 1264 Micro Imager 490 Microinjector 1174 MicroINJECTOR microinjection system 2794 Microliter plates 1598 Micro-manipulator 1174 Micronized powdered media 545 Micropipets 1352 Microplate analysis software 420 Microplate Bookcase 1864 Microplate Coating Systems 2131 Microplate Data Analysis Software 530 Microplate fluoromete 172, 555 Microplate Handler 2968 Microplate hybridization assays for HIV, MTB 1051 Microplate Luminometer 555 Microplate Nephelometer 555 Micro plate Readers 172 Microplates 2658 Microplates for niche applications 2281 Microplate washer 651 Micropreparative technique 2538 Microprocessor syringe infusion and peristaltic pumps 1311 MicroPro line 1502 Micropropagated tree rootstocks 973 Micropropagated virus-free sweet potato 1440 Micropump 1124, 1757 MicroRNA detection 1736

Microscopes for image analysis and histology 2948 Microscope Slide Boxes 24 Microsealed drug delivery systems 1743 Microsequencer 19 Micro-Skater 988 Microslide file boxes 634 Microstructure technology 2636 Microtiter 988 Microtiter System 1021 Microwave viral and microbial inactivator 705 Microwell & Membrane substrate 379 Microwell ELISA 1878 Microwell Phosphatase Substrate System 1640 Microwell plate coating 2023 Microwell plate readers 1488 Migrastat 2385 Milk sample container 1801 Mimetic Affinity Media 2330 Miniature CCD and photodiode array spectrometers 2064 Miniature digital temperature loggers 2904 Miniature solenoid pinch valves 1252 Miniature teflon solenoid valves 1252 Minicycler 1892 Mini electrophoresis apparatus 1749 Mini-gel system 1021 Minimalistic vectors 1916 Miniprep kits 2365 Mini Sample Processor 647 Mircera 2452 MiRNA Expression Detection 1401 MiRNA Labeling and Detection Kit 2827 Mismatch binding proteins 1171 Mixed RNA/DNA 855 Mixers 720 Mixing agitator 1263 MMP Inhibitors 736, 2182 32mm Syringe filter 1160 Mobile pilot plants 2589 Modeling software 2793 ModelMaker 726 Model 125 Single Probe Temp 1301 Model system gene/comparative genome 1097 Modification methods of gene expression 1194 Modified exendins and exendin agonists 140

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Keywords Index Modified oligonucleotides 1619 Modifying enzymes 729, 1175 Modular aseptic cleanroom 1937 Modular Bioreactor systems for groundwater 867 Modular clean room structure 757 Modular Digital Pump 647 Modular Laboratories 700 Modular rooms 1331 Modular Titration System 1786 Modulating enzyme therapeutic agents 865 Modulation of plant growth 649 Modulator 1897 Modules for membrane and glass cDNA arrays 364 Moisturizer 663 Molecular hybridization 999 Molecular biology assays 167 Molecular biology buffers and reagents 545 Molecular biology grade specialty chemicals 529 Molecular biology kits 287, 729, 2304 Molecular biology reagents 1065, 1202, 1246, 1804 Molecular biology research reagents 1104, 1105, 1106, 1127 Molecular Biology Separation devices 2406 Molecular biology tools 209 Molecular cytogenetics 2188 Molecular diagnostics 1214 Molecular diagnostics kits 1223 Molecular discovery 1734 Molecular drug design 1104, 1105, 1214 Molecular genetics research devices 1904 Molecular modeling software for Drug design 1706 Molecular Operating Environment 713 Molecular Probes 1907 Molecular probes for drug discovery 2734 Molecular reagents 592 Molecular sieve carrier 1022, 1105 Molecular technology for the control of gamete viability 619 Monitor — for identification of bacterial 1364 Monitoring & control systems 2411 Monitoring and hand held meter-test for kidney function 1620

969

Monitoring methods of parathyroid hormone 2490 Monoclonal and polyclonal antibodies 603, 654, 672, 715, 1123 Monoclonal and polyclonal antibodies of human 1304 Monoclonal antibodies 48, 121, 151, 176, 411, 454, 486, 502, 549, 702, 727, 755, 860, 873, 914, 974, 1025, 1080, 1084, 1241, 1705, 1815, 2689 Monoclonal antibodies against hepatitis virus 2306 Monoclonal antibody 891, 1041, 1695 Monoclonal antibody against hepatitis B virus 2264 Monoclonal antibody for treating GVH 540 Monoclonal anti-cytokeratin 2969 Monoclonal Free Proteins 812 Monoclonal/polyclonal antibodies 1002, 1096, 1198, 1605, 2011 Monoclonals specific for lung and colon cancer 1750 Mono-cyclodextrin derivative 732 Mononucleotide polymorphic gene typing 1526, 1736 Mono-Vacc 802 MoquitoLarvicide™ 68 Morphine Rectal Delivery System 687 Morphine rectal device 583 Morpholino antisense oligos 1211 Mounting media 634 MRNA purification 985 MS therapeutic agents 1799 Mucosal vaccines 817 MUC-1 peptide vaccine 814 Multiblock system-flexible networked PCR 1358 Multi-channel, biosensor-based analyzers 2037 Multi-Application Detection Kit 1460 Multiblot Replicators 2831 Multichannel analyzer 1854 Multichannel Date Recorder 1854 Multichannel pipettes 1391 Multichannel sampling system 2012 Multicomponent vaccines 2551 Multicont fermentation 2892 MultiCycler 547

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Multidetection microplate reader 530, 554 Multidisciplinary expertise 1476 Multi-Fermenter 197 Multifunctional building blocks 772 Multifunctional protein 191 Multikine™ for treatment of cancer 684 Multimedia teaching instruments 2556 Multimode Step Index Fiber 2271 Multipin Synthesis Kits 1883 Multiple Drug resistance Antibodies 467 Multiple PCR for HBV, HCV and HIV 2554 Multiple Peptide Synthesizer 36, 516 Multiple products for fertility diagnostics 1299 Multiple seed products 1944 Multiple Tissue Northern Blots 768 Multiplex cytokine immunoassays 368 Multiplexed Phosphorylation State Analysis 304 Multiplex PCR 497 Multi-Probe Temp. Monitor/Alarm 1301 Multi-Reagent Washer 988 MultiSpectral imaging 829 Multivalent Vaccine 1538 Multi-well filter 2915 Multi-well peptide synthesizer 2801 Multi well plates for high through screening & combinatorial chemistry 2914 Murine monoclonal antibodies 333 Muscasinic receptor antagonists 921 Mutagenesis kit for double-stranded DNA 769 Mutation detection kits 1171 M-Vax immune-based therapy 260 MX6 1775 Myotonic Dystrophy DNA test 1221 Mycoherbicide 455 Mycoplasma 2557 Mycoplasmal screening assays 437 Mycorrbizal innoculants 2667 MycoSelect 1947 Mycotoxin Adsorbent 1533 Myeloid progenitor inhibitory factor-1 1354 Myloral 255 Myoblasts 679 Myoblast transfer therapy 679 Myoscint 1914 Myasthenia gravis test 1221

NanoChip Molecular-Biology Workstation 1954 Nanoliter pumps 1258 Nanoparticles 1956 NANOSEP Filter Capsule 2140 Natalizumab (Lucentis) 386 National Medicinal Plant Gene Bank 1483 Natrecor® BNP 2508 Natriuretic peptides 412 Natural and recombinant biologicals 1849 Natural antibodies 279, 1770, 1794 Natural auxin 227 Natural chitin-based nematicide 1393 Natural compounds 1807 Natural food ingredients 976 Natural health food 432 Natural marine products 1970 Natural medicinal plants 1336 Natural pesticide 492 Natural plant extracts 1850 Natural products 49, 182, 186, 224, 227, 435, 445, 546, 552, 577, 584, 601, 650, 652, 653, 691, 701, 717, 732, 733, 738, 739, 770, 771, 852, 891, 916, 917, 926, 970, 1000, 1003, 1014, 1020, 1024, 1054, 1108, 1135, 1155, 1312, 1319, 1324, 1334, 1347, 1396, 1532, 1607, 1621, 1649, 1740, 1768, 1782, 1813, 1858, 1866, 1873, 1876, 2173, 2222, 2373, 2515, 2519, 2550, 2614, 2631, 2802, 2851, 2853, 2861, 2908, 2932 Natural source-based pharmaceuticals 2723 Navance™ interleukin-4 receptor 1418 Near infrared oxygen sensors 1556 Neck Recovery Granule 724 Needle-free drug delivery systems 2528 Needle-Free Syringe 1810 Neisserio meninpitidis vaccine 1093 Neomorphic Genome Sequence Development Kit 1982 Neonatal Screen 341 Neoprobe 1983 NEPHELOstar 556 Nephrin gene and protein 498 Nerve agent antidote 2662 Nerve conduction enhancing drug 20 Nested oligonucleotides 84 Neumega 1206

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Keywords Index Neumega oprelvekin 1206 Neupogen 971 Neupro rotigotine 472 Neural network simulator 1989 Neural Stem Cells 880 NeuroCell 922 Neuro cell-PD 920 NeuroCRIB 880 Neurological disorder diagnostics 235 Neuropeptides 126 Neuroprotective human T-cells 2332 Neurotrophic cytokine 1724 Neurotrophic factor therapeutics 1948 Neutralase for cardiac surgery 1373 Neutralizing antibodies 58 Neutralizing antibody assay 235 Neutrophil inhibitory factor 820 New agricultural products 77 New biopharmaceuticals 986, 2111 New discovery drugs 2146 New drug candidates 2789 New Drug Development 2157 New drug discovery route 2223 New drugs 2796 New feed 90 New Fusion Cloning System 1370 New gene discovery technologies 938 New genetic technologies for tree crops 1134 New hand-made organic compounds 223 New human proteins 2509 New protein-based biocatalysts 950 New reagents 716 New small molecule drugs 124 New technology of drug discovery 947, 948 New therapeutical products 2386 New type biotech drug software 183 New ultrasensitive chemiluminescent reagents 1735 New vaccines against HIV 877 New vaccine technology 877 Nicotine receptor antagonists 1685 NIR Moisture Meters 1616 Nitrate test kits 2745 Nitric Oxide Analyzer 170 Nitrogen fixing bacteria 1486 Nitroglycerin transdermal patch 2749

971

Niuhuang Jiedu pian 730 NMR spectrometers 2843 NMR spectroscopy technologies 2816 Nonclinical safety testing 1356 Non-contacting infrared temperature measurement devices 2079 Non-glass pH probes 2527 Non-human animal apolipoprotein 1077 Non-human carbonyl hydrolase mutants 1185 Non-Interfering Protein Assay 1231 Noninvasive cholesterol test 1408 Non-invasive drug delivery methods 1385 Non-invasive glucometry 552 Non-invasive prenatal diagnosis 229 Nonmetallic fluid handling systems 1038 Non-natural amino acids 2347 Non phenolic method to isolate RNA, DNA/RNA 2724 Non-porous supports 1844 Non-radiactive kinase assay kits 673 Non-radioactive labels 833 Non-refrigerated Bath/Circulator 1987 Nonspecific cellular immune stimulation 1154 Non-sterile animal sera 2761 Non-targeted activation of endogenous genes 239 Non-thrombogenic coatings 1782 Nonviral gene delivery system 2324 Non-viral gene delivery systems 1818 Non-viral gene delivery therapy drugs 1184 Non-viral gene transfer vector for gene therapy 1886 Normal animal cell cultures 659 Normal human cell cultures 659 Normal human cells 765 Northern Blot kits 1179 Norwalk virus vaccine 274 NO synthase inhibitors 181 Novantrone 1418 Novastan® 2733 Novel bioactive peptides 280 Novel biopharmaceuticals 1247 Novel cytokine (chemokine) detection kits 2942 Novel discovery and screening technology 877 Novel Drug Delivery Systems 2207 Novel drug 948, 2208

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Novel drug development 2217 Novel drug discovery 376 Novel drug screening technology 738 Novel high throughput screens 878 Novel kits 438 Novel medical devices 1111 Novel therapeutical compounds 719 Novel ultrasensitive rapid diagnostics platform 1148 Novel varieties of plants 2256 Novel variety for plant breed 1204 Novomab G2 2051 Nuclear Acids Purification Kits 537 Nucleic acid analogs 562 Nucleic acid derivative 204, 2416 Nucleic acid extraction and purification technologies 612 Nucleic acid extractor 612 Nucleic acid labeling and detection kits 1640 Nucleic acid molecules of transgenic plant cells 262 Nucleic acid purification kits 1065 Nucleic Acid Purification Systems 382 Nucleic acid synthesis 1370 Nucleosides and derivatives 2202 Nucleotides 718 Nucleotide sequences coding for the cls gene 897 Nuleic acid purificator 612 Nuleotide analogue 1259 Nutraceuticals 31, 125, 552, 577, 595, 601, 604, 639, 652, 701, 732, 848, 1006, 1014, 1054, 1057, 1312, 1334, 1481,1533, 1557, 1649, 1740, 1759, 1782, 1792, 1893, 2566, 2836, 2932 Nutralase 1373 Nutriceuticals 926, 970 Nutrient drug 604, 2520, 2502 Nutrilipid 604 Nutrison 604 Nutritional supplements 1492, 2056, 2465, 2502, 2895 Nutsche Filter Systems 2277 Nvironmental pollutant detector 352 Nyotran 214 Nystatin 2959

O2/CO2 Respirometer 788 OCTYL-Glucoside & X-GLUC 1435 Ocupress 2120 OEM precision liquid handling equipment 647 OEM sterile filtration technology 624 OGT 719 2127 Oil-free vacuum pumps 568 Oligo (dT)-cellulose columns 1911 Oligonucleotide Analytical + Purification Reagents 1529 Oligonucleotide design software 37 Oligonucleotide LC Standard 2901 Oligonucleotides 562, 1062, 1539 Oligonucleotide synthesizer 1539, 1943 Oligo-PCR/Primer design Software 1706 Oligo synthesizer 190, 1183 Omalizumab (Xolair) 1186 Omniferon 2865 Oncology therapeutics 1679 Oncolytic drug 492 Oncoprotein kinase 2573 OncoScint 870 Oncovax-CL 1575 One cell systems technologies 2088 One step H-pylori test 419 One step rapid assays 928 On-line data handling equipment 9 Online general analyzer 1370 Online Information Service databases 714 On-line respirometers 216 On site diagnostic for toxin 300 On site test for toxins in sea food products 300 On-site tests for drugs of abuse 932 On site tests for veterinary medicine diagnosis 300 Ontak 1710 ONYX-015 for treatment of anticancer 2092 Oocyte spindle imaging 829 Open Architechture Laboratory Software 832 OpenGene automated DNA sequencing system 2878 Optical density sensor 699 Optical interference filters 154, 2078 Optical purity detector of organic compounds 644 Optical sectioning microscopy 2073

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Keywords Index Optical systems for emission microscopes 2096 Optical technology devices 1788 Optisep 2030 Oral and intranasal delivery 360 Oral antibody 1413 Oral anti-HTV vaccine 552 Oral Calcitonin 2807 Oral controlled release drugs 1240 Oral delivery of calcitonin 1371 Oral delivery of HGH 1371 Oral delivery of peptides 2807 Oral delivery peptides 817 Oral delivery systems for insulin 2338 Oral drug and vaccine delivery 1032 Oral drug delivery methods 272 Oral fluid collection device 1059 Oral Guard Gargle 725 Oral Heparin 1028 Oral herpes 257 Oral human growth hormone 1032 Oral insulin 817 Orally-active, small molecules 697 Oral, non-cytotoxic anticancer (colorectal) drug 2627 Oral peptide 1688 Oral plant vaccines 274 Oral salmon calcitonin 817 Oral vaccines 817, 1032 Organic chemical specialities 1115 Organic manure 1011 Organic reagents 1803 Organic substances analysis system 149 Organ transphants/culture 679, 716 Organ transplants 84 Organ transplants 256 Organ transplants/culture 253, 588, 670, 676, 681, 728, 758, 767, 792, 834, 874, 912, 917, 957, 962, 1020, 1022, 1069, 1111, 1118, 1174, 1202, 1255, 1321, 1341, 1347, 1432, 1434, 1536 Organ transplants/culture products 556, 703 Orthoclone 2112 Osteomrsk Assay 2118 Osteopatch 2134 Osteoporosis animal models 1969 Osteoporosis office test 463

973

Osteoporosis peptides 2722 OTC HIV Urine Collection System 606 Other centrifugal separation systems 88 Otitis media vaccine 1093 Ovagen follicle stimulating hormone 1381 Ovarian and gastro intestinal tumor 451 Ovarian cancer monitor 692 Overhead electrical stirrers 595 Ovo-transferrin 1470 Oxalate detection kit 1561 Oxidative Stress Kits 497 Oxidized LDL Autoantibody Test 1809 Oxilan® (Ioxilian) injection x-ray contrast media 811 Oxitabs 2665 Oxygenated, incubated shaker 1183 Oxygen sensors 1110 Ozone generator 1046 Pacesetter 1822 Packaging equipment 1966 Paclitaxel 158, 1108, 1439 Paclitaxel for treatment of solid tumors 2336 PA-1648 for tuberculosis 2161 PAI antagonists 820 Pain Cell Therapy 880 Pain-killer 1031 Palifermin (Repivance) 132 Panel meters 2005 Panitumumab Bectibix 132 Panitumumab (Vectibix) 132 Panretin Topical 1710 PanStabilizer 925 P53 antibodies 1659 PANVAC-VF 2754 Paper and glass fiber 47 Paper labels 1437 Parallel Purification systems 510 PARASEP 1522 Parasitic & viral IFA & ELISA 2957 Paratyphoid A 1751 Parenteral nutrition pharmaceuticals 318 PARS Inhibitors 1289 Particle size analyzers 1788 Particle size and zeta potential analyzers 576 Partitioned plant extracts 1850

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Parvovirus B19 tests 541 Pasteurella vaccine 583 Patented expression profiling technology 1182 Patented food grade vectors 2022 Patented genetically engineered hepatitis B antigens 386 Patented micro-bead drug technology 2726 Patented peptide instruments 779 Patented portfolio drugs 2455 Patented Soybean Strain 2822 Patented technologies for novel drug delivery 2087 Paternity test 2315 Paternity testing 578 Paternity testing 1215 Pathogen detection devices 826 Pavallel synthesis and sample preparation technologies 2684 PCR diagnostic kits 1687 PCR Equipment 1657 PCR kit for food testing 528 PCR kits 638, 1682 PCR Mycoplasma Detection Kit 233 PCR Optimization kit 808 PCR Primer Kit for Cytokines 1177 PCR primers 1163 PCR programmable thermal controllers 1174 PCR related product 590 PCR System 1056 PCR thermal cyclers 2478 PCR workstations 1857 PDGF Antagonist 2009 PDNA 974 Pectinase 315 Pediat-DNA probe amplification 864 Pegademase bovine injection 1052 PEG-gluco-cerebrosidase 1052 Peginterferon-alfa-2b 2491 PEG-Intron® A 1052 Peg reagents 329 Penetrating skin absorption technologies for TCMM 1964 PentaLyte 536 Peptidase A isozyme 281, 2630 Peptide agents 1342 Peptide antisera 250

Peptide arrays 774 Peptide arrays for binding assays 1578 Peptide chains 774 Peptide/Chelator 2431 Peptide coupling reagents 1691 Peptide drugs 55 Peptide extracts 901 Peptide HPLC columns 746 Peptide instrumentation 55 Peptide instruments 2944 Peptide libraries for solution assays 1578 Peptide library 163, 282, 505, 2273 Peptide nucleic acid 1342 Peptide purification system 1261 Peptides 614, 842, 901, 944, 1374, 1605 Peptides and gene synthesis 1358 Peptide sequencer 5, 33, 281, 505, 506, 773, 1084, 1585, 1606, 2185, 2274, 2302, 2581 Peptides for antiinfective & anticancer 903 Peptides relating to metabolic diseases 1920 Peptides screening devices 280 Peptide syn 2570 Peptide synthesis 109 Peptide synthesisers 250 Peptide synthesis hardware and software 1492 Peptide synthesis resins 773 Peptide synthesizer 5, 188, 280, 281, 477, 505, 506, 773, 774, 855, 886, 1084, 1091, 1585, 1606, 2185, 2272, 2299, 2427, 2525 Peptide vaccine 814, 1286 Peptidomimetic-based pharmaceuticals 2186 Peptones for fermentation 2591 Peptones for fermentation industry 2106 Pepudomirnetics 1940 Percocet 1031 Percodan 1031 Peridinin chlorophyll protein 309 Permethrin 771 Personal monitors 967 Pesticides 1481, 367, 520, 577, 593, 652, 770, 970, 1054, 1649 Pest resistant fruits and vegetables 439 PET 1922 Pexelizumab 2316

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Keywords Index PEXY321 1418 P53 gene therapy 623 P-gp inhibitors XR9576 2936 Phage display platform technology 984 Phage Therapy Rapid Diagnostic Kits 446 Pharmaceutical active ingredients 2243 Pharmaceutical-based on natural product discoveries 2143 Pharmaceutical compositions 564 Pharmaceutical development 764 Pharmaceutical glycoprotein 2110 Pharmaceutical-grade custom synthesized oligonucleotides 2070 Pharmaceutical grade peptide 126, 150 Pharmaceutical grade proteins 150 Pharmaceutical ingredients 2507 Pharmaceutical intermediates 507, 2175, 2203, 2713 Pharmaceutical raw material production 597 Pharmaceutical research software 2276 Pharmaceuticals 1431 Pharmaceutical screening software 275 Pharmacogenetics profiling 1697 Pharmacogenomics 1182 Pharmacokinetic 1791 Pharmacophylogenetics 1483 Pharmagene 1988 Pharma-synthesizer 469 Phenserine 276 Phosphate binder 1161 Phosphopeptide-specific antibodies 489 Phosphorylation-State specific antibodies 488, 673 Photoacoustic detectors 1938 Photobioreactors 297 Photodynamic therapy for cancers affecting bone marrow 2750 Photofrin & Proleukin 1710 Photometric titration methods 2460 PH/Redox measurement systems 1839 Piezoelectric instruments 2817 Pig organs for human transplants 1255 Pilot plant and industrial scale LC columns 1896 Pilot plant fermenters 1450 Pilot plant processors 2310

Pilot plant scaleup and purification 1919 Pilot-scale and production-scale HPLCs 510 Pilot scale bioreactors 217 Pilotscale freeze dryers 2874 Pipette Calibration System 215 Pipet washer 18, 389 Pirouette 1448 Pivotal 2034 P53-kit for mutation detection 1452 Pl6 & p27 gene therapy 1890 Planova Virus Filter 218 Plant biotechnology breeding 2254 Plant breeders 2257 Plant cell culture 1088, 1172, 1204, 2017 Plant cloning technology 2257 Plant cloning vector 1172, 2245 Plant-derived products 178 Plant derived vaccines 274 Plant fertilizer 240 Plant Fluorescent databasing 656 Plant functional genomic sequencing 1824 Plant gene technology 114 Plant genetic engineering technologies 2014 Plant growth cabinets 2478 Plant growth chambers 1048 Plant growth chambers and rooms 810 Plant growth monitoring 1274 Plant growth regulator 507,1204, 2191 Plant growth systems 2102 Plant new varieties 509 Plant pathogenic bacteria identification 1959 Plant production rooms 810 Plant rooting lectin 2778 Plant tissue culture 69, 133, 384, 1172, 1204 Plant tissue culture bioreactors 1832 Plasma expander 1305 PlasmaSep Plasma Collection System 1330 Plasmid DNA 975, 2141 Plasmid DNA construction 2366 Plasmid DNA purification 471, 1195 Plasmid DNA purification kit 1081 Plasmid DNA transduction kit 1081 Plasmid minipreps 1001 Plasmid Purification Kits 2358 Plastic bottles 2250

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Plastic microplates 1283 Plasticware (tissue culture) 381 Plate and frame filtration device 2030 Platelet aggregation inhibitor 2722 Platelet Investigation System 1321 Platelet replacements 645 Platelet Storage Solution 1701 Platform shakers 995 PMA 2722 Pocket-gels 1279 Pointmaker 557 Pollution control devices 1045 Polyclonal and monoclonal antibodies 334, 438, 775, 837 Polyclonal antibodies 56, 57, 70, 209, 292, 356, 362, 873, 914, 990, 1421, 1441, 2514 Polyclonal antibodies related antigens 2067 Polyclonal antibodies to PKC isoforms 2422 Polyclonal antisera 1068 Polyclonal egg yolk antibody 891 Polyclonals 461 Polymer conjugates 1928 Polymer crystallite technology 1008 Polymer drug 2303 Polymeric HPLC columns 350 Polymeric immunoglobulin receptor 1161 Polymeric stationary phases 2099 Polymeric surface-active agent 350 Polymerization Reactor 43 Polymerized human serum albumin 1161 Polymerized liposome 2513 Polymer-modified synthetic proteins 140 Polymorpha expression technology 2435 Polypeptide drugs 2273 Polypeptide synthase enzymes 1639 Polypeptide synthase genes 1639 Polypropylene (natural and pigmented) piping systems 1251 Polysaccharid therapeutic proteins 1282 Polysubstituted phycocolloids 635 Polyvalent Bacterial Antigen 900 Polyvalent serum 400 Polyvinylidene fluoride piping systems 1251 P53 oncoproteins 1087 Porcine pancreatic enzymes 2501 Porosity analytical devices 2279

Porous glass carriers 1567 PorSign 1288 Portable Gas Chromatograph 2193 Porzyme 1116 Potential drug candidates 2211 Poultry diagnostic kits 1627 Powder activator 2345 Powder control booths 1044 Powderject Hepatitis B DNA vaccine 2284 Power-Prep Sample Cleanup System 1129 P27/pl6 gene therapy 1278 Pramlintide (Acetate) 140 Precast gels 1127 Precast gels with sample wells 1279 Precipitating antibodies 1123 Precision delivery system 2293 Precision liguid delivery instruments 1010 Precision weighing balances 2295 Preclinical 450 Preclinical diagnostic testing kit 1497 Pregabalin (Lyrica) 2205 Pregnancy test 1516, 2686 Pregnancy tests (after 10) 2955 Prehybe DNA recombinant protein 1725 Prenatal genetics diagnostic system 479 Preparative free-flow zone electrophoresis equipment 169 Prepared culture media 1303 Prepared microbiological media 2031 Prep continuous free flow electrophoresis 2391 Pre sasy DNA gels 1321 Preserv Cyt Solution 884 Pressure & flow control systems 39 Preventive vaccines 2754 Pride brand seeds 1713 Primary antibodies 2455 Primary Antibody Database 1936 Primary cell culture 2262 Primary hepatocyte culture kits 655 Probes 474, 1485 Probiotics for neonatal pig and lambs 2352 Process analyzer 2095 Process automation systems 297 Process controllers 2530 Process manufacturing software 787 Process Photometer 1262

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Keywords Index Process plants engineering for biotechnology industries 1138 Process scale biopharm monitors 2907 Process vessels 894 Production-scale synthesizer 838 Productive standard of Traditional Chinese Pharmacy 1964 Products 447 Products for peptide synthesis 597 Product Testing Software 442 Professional instruments 949 Professional valves 89 Programmer’s Library 889 Proleukin 734 Promoter-gene-finding tool 979 Proprietary cell culture systems 675 Proprietary genetic probes 1095 Proprietary multi-locus DNA-based probe 704 Proprietary oral drug systems 908 Proprietary plasmid vectors 1537 Proprietary platform technologies 239 Proprietary platform technologies into a complementary drug discovery 877 Proprietory software 1350 Prosorba® column 862 Prostaglandin 1033 Prostate cancer therapy 2813 Prostate vaccine 2091 Protease inhibitor 820, 1622 Protective packaging systems 2263 Protein A Medium 1783 Protein analysis system 1651 Protein and antibody purification 1428 Protein and nucleic acid arrays 1231 Proteinase inhibitor 104 Protein assay kits 1608 Protein cancer therapeutic 175 Protein carrier 1622 Protein chemical synthesis 1893 Protein chemistry synthesis 2074 Protein classification techniques 2698 Protein coated latexes 1506 Protein coding region prediction and gene modeling 183 Protein concentrator 493 Protein conducting channel 21

977

Protein crosslinking reagents 2598 Protein data bank 2341 Protein 2-dimensional electrophoresis softwares 1610 Protein drugs 1171 Protein expression and localization database 1708 Protein expression systems 2383 Protein expression vector 263, 1001 Protein growth fishs 201 Protein Identification Package 1772 Protein Isolation Kit 2329 Protein Kinase Inhibitors/Staurosporine 1597 Protein kinase signal transducers 1626 Protein knock-out technology platform 2937 Protein modification reagents 2598 Protein-peptide sequencer 429, 2341 Protein Predictor 242 Protein processing system 429 Protein purification 1101 Protein purification/expression technology 2061 Protein purification stragegies 2340 Protein separation/purification technologies 2715 Protein sequence analysis software 538 Protein sequence analyzer 538 Protein sequencer 188 Protein sequencing 1326 Proteins for cell signal transduction research 2821 Protein supplements 457 Protein synthesizer 188, 1091 Protein tyrosine kinase 111 Proteoglycan 252 Proteolink Technology 906 Proteolipid 252 Proteolysin 252 Proteolytic enzymes 284, 315 Proteome System Analyzer 2756 Proteomics/Bioinformatics 1217 Proteomic sequencing 2362 Proteomics-implemented methods for target validation 2458 Proteomics platform 10 Prototypes for microtite plates 1379 PSA-enzyme 818

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P53 Sequencing Kit 481 Psoriasis therapeutic 1194 P53 Tumor Suppressor Gene 2491 Pulmonary drug delivery method 51 Pulmonary-respirator devices 1392 Pulse diagnosis device 313 Pump spray 1564 Pump spray systems 1757 Pure chymosin 976 Pureflo pumps 1564 Purification devices 296, 585 Purification downstream processing 2213 Purification technology for bioprocess 1920 Purified antigens 627, 1123 Purified Collagen 737 Purified Cryoprotectants 2312 Purified enzymassay kits 1055 Purified enzymes 143 Purified human transferrin 1501 Purified irnmunoglobulins 1123 Purified microenvironment technique 2498 Purified plasma proteins 1501 Purified protein derivative 99, 362, 1059, 2498 Purified proteins 1068, 1691 Purified serum proteins 2172 Purified syphilis antigen 1690 Purified viral proteins 34 Purine nucleoside phosphorylase inhibitors 359 Purity tests for elk and red deer 565 Pyridorin 498 QC Software 561 Qinggong Changchun Capsule 724 Qingre zhike keli 2958 Q-sept automatic sterile sampler 1403 Quality antibodies 873 Quality assurance program for GMP 1789 Quality Control Panels 561 Quality research equipment 2259 Quant Flow Immunoassays 372 Quantitative Immunoassays 2432 Quantitative PCR services 108 Quantitative tests for DNA contamination 166 QuantiZyme Assay Kits 431 Quick disconnect couplings 780 Quick test bovine colostrum 1870

Quick test calf IGG kit 1870 Quizix Pump Systems 2862 R&D testing equipment 1397 Rabbit complement 928 Rabies glycoprotein G 1200 Rabies vaccine 2436 Radiation safety lab apparatus 2122 Radioactive labeled compounds 2428 Radioimmunoguided surgery cancer detection system 1983 Radioimmunotherapy 822 Radioisotope instruments 1530 Radiolabelled 150 Radio-labelled peptide synthesis 2677 Radiopharmaceutical compound 157 Radiosensitizers 645 Ragweed 96 Random access immunoassay instrument systems 734 Random addressable Anti-Blooming 750 Ranolazine-metabolic modulator 849 Rapidase 976 Rapid bio-dignostic test devices 365 Rapid diagnosis device 2107, 1144 Rapid diagnostic kits 1168 Rapid diagnostics 198 Rapid DNA purification process kit 391 Rapid HIV-1 Urine EIA 606 Rapid immunodiagnosis 2377 Rapid method for the detection of cryptosporidium 1846 Rapid Microbial Testing Systems 685 Rapid pregnancy test 1025 Rapid radioimmunoassay 295 Rapid scanning monochromator 2071 Rapid-Screen cDNA Library Panels 2108 Rapid serum tests for Hepatitis A and Tuberculosis 2471 Rapid test devices 1816 Rapid test for H. Pylori infections 805 Rapid Tests kits for bacteria identification and quantification 1845 Rapid Test technique 1815 Rare cell analyzer 1419 Ras oncogene inhibitors 2086

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Keywords Index Rat GRO/CINC EIA kit 1420 Rat insulin 837 Rationally designed synthetic peptide-based vaccines 881 Rat Leptin EIA Kit 1420 Rat models for Heart failure 1201 Rat models for obesity 1201 Rat models for Type 2 Diabetes 1201 Raw animal biological products 164 Raw material of medical grade films 2600 RDNA calfscours vaccine 513 RDNA origin for injectin 2541 RDNA pig scours vaccine 513 RDNA techniques 1643 ReactechSynthesizer 36 Reaction blocks 1292 Reactors 720 Reactor System-for wastewater treatment 232 Ready Western Single/Multiple Tissue Blots 955 Reagent 823 Reagent buffer 226 Reagent for the testing of human drug metabolism in vitro 861 Reagents 55, 302, 374, 402, 409, 447, 453, 471, 476, 476, 556, 567, 596, 614, 623, 632, 643, 650, 654, 659, 681, 703, 710, 715, 717, 738, 753, 760, 767, 777, 780, 789, 842, 859, 879, 885, 886, 905, 959, 989, 990, 997, 1002, 1003, 1009, 1020, 1025, 1029, 1067, 1076, 1104, 1118, 1121, 1198, 1199, 1280, 1286, 1336, 1341, 1367, 1423, 1426, 1505, 1532, 1758, 1781, 1792, 2163, 2704 Reagents & molecular cloning products 375 Reagents and kits for differential display 1220 Reagents for automated 3- and 4- color immunophenotyping 309 Reagents for biochemistry 579 Reagents for biology research 1318 Reagents for cell pathology research 2417 Reagents for DNA analysis 1921 Reagents for flow cytometry 1542 Reagents for genetic engineering 1968 Reagents for molecular biology research 1357 Reagents for molecular/cell biology research 1080 Reagents for PCR 953

979

Reagents for synthesis 223 Reagents kits 1558 Real-time expert system 1239 Real Time Quantitative PCR Machines 382 Receptor and enzyme screening technology 2063 Receptor antagonist 159, 1695 Receptor binding assays 2043 Receptor binding cell harvesters 2940 Reciprocal shakers 995 Recirculating Coolers 1145 Recombinant adeno-associated vector 269 Recombinant adenoviral vector 623 Recombinant alpha 1-antitrypsin 103 Recombinant animal parasite vaccines 513 Recombinant antigens and antibodies 251 Recombinant collagen 1113 Recombinant containment technology 1331 Recombinant DNA 619, 1157, 1169, 1257, 1441 Recombinant DNA drug complex 1059 Recombinant DNA origin human insulin 133 Recombinant DNA platform technology 1360 Recombinant DNA synthesis 238 Recombinant expression technology 2049 Recombinant gelatins 1113 Recombinant G protein-coupled receptors 482 Recombinant HIV, HTLV, HCV Proteins 914 Recombinant human drug-metabolising enzymes 861 Recombinant human factor IX 1206 Recombinant Human Growth Hormone 621 Recombinant human interleukin-11 1206 Recombinant human lactoglobulin 64 Recombinant human Parathyroid hormone 95 Recombinant human proteins 2681 Recombinant human superoxide dismutase 523 Recombinant insect proteins 72 Recombinant interleukin 2970 Recombinant mistletoe lectin 566 Recombinant opiate receptors 30 Recombinant osteogenic protein-1 827 Recombinant platelet activating factor acetylhydrolase 1380 Recombinant pl6/p53 viral vector 1335 Recombinant precursor human IL-LB 751 Recombinant proeins 344 Recombinant prostaglandin syntheses 2124

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Recombinant protein 2672 Recombinant protein expression 234 Recombinant protein purification tags 878 Recombinant proteins 57, 411, 454, 502, 2290 Recombinant proteins for mouse and human cytokine analysis 2227 Recombinant receptor technology 30 Recombinant regulatory peptide hormone replacement 434 Recombinant subunit RSV vaccine 694 Recombinant subunit vaccine 2855 Recombinant superoxide dismutase 181 Recombinant TPO 1168 Recombinass-based methods for producing expression vectors 769 Recombination insulin 126 Recombinent protein 1508 Reconditioned equipment 791 Reconstituted human epidermis 2583 Reconstituted human tissues 2583 Reculated gene theraphy system 212 Red blood cell 775 Red blood cell substitute 460 Red cell agglutination technology 63 Refrigeration systems 1048 Refrigerator 1587, 1764 Refrigerators/freezers 1188 Refurbished analytical instruments 135 Registered Magaclone 1739 Regressin 436 Regulated antigen delivery system 259 Regulatory affairs and quality systems 1647 Relaxin 804 Remanufacture Autoclaves 2171 Remember-FX 848 RenCyte Fibroblast 1806 RenCyte Hybridoma 1806 Reperfusion post myocardial infarction 259 Replacement specialty light bulb 588 Reproduction technologies 2928 Research apparatus for biotechnology 1932 Research chemicals 2777 Research DNA kits 1009 Research kits 2425 Research Microspheres and Particles 981 Research reagents 282, 1009, 1560, 1793, 2164

Resin and fiber 219 Resolve IEF Gels 1551 Respiratory disease vaccines 2551 Respiratory vaccine 583 Rester-IVG 267 Restriction endonuclease 729, 1196, 1820 Restriction enzymes 287, 340, 1106, 1175, 1196, 1357 Retractive Index Detector 978 Retroviral gene therapy vectors 666 Retroviral vectors 676, 1089 Retrovirus detection methods 2370 Reversed phase polymeric 2099 Reverse osmosis 1341 Reverse Osmosis Systems 1015 ReversePrime 1220 Revolution Prep Machine 1183 RhAntithrombin III 1249 RhBMP-I 1206 R-hCG 2541 Rheumatoid arthritis therapeutic vaccine 2742 Rhizobium inoculants 1847 RhPTH (preosTM, tolambaTM) 1931 RhTBP-1 2541 Rhu epoetin alpha 1005 Rhu epoetin beta 1005 Rhu epoetin delta 1005 RHu Epoetin Omega 1005 RIA and ELISA kits 416 Riboflavin Binding Protein 2635 Ribonuclease resistant RNA 116 Ribonuclease trypsin inhibitor 548 3’-ribose primers 1493 Ribosome binding sequence 609 RIFN-beta 558 RIFN-gamma 558 Rituxan 1186, 1386 Ribonudease inhibitor 837 Rm CRP 1412 RNA and DNA-free ultrapure water 2919 RNA/DNA purification kits 2027 RNAimage 1220 RNA Isolation Kits 1242 RNA modified building blocks 1370 RNA Oligonucleotides 920 RNA polymerases 1175

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Keywords Index RNASCREEN 977 RNA synthesizer 1715 RNA Transduction Delivery System 1493 Robotic assay composer 2705 Robotics 782, 1298 Robotics aided drug design 2511 Robotics devices 2102 Robotic work cells 2623 Robotic workstations 854 Rodenticide 1151 Roller apparatus 317 Rose oil in cultured plant cells 2200 Rotary cell culture system 2681 Rotational vacum concentrators 1407 R-phycoerythrin 852 R-Series BenchCel® Microplate Handing System 2850 RtPA Tissue plasminogen activator 558 Safe-Scint 1521 Safety cabinets 1343 Safety-gas detection equipment 967 Safety testing method of biopharmaceuticals 755 Saliva alcohol test 932 Sample concentrators with pressure control 1218 Sample dividers 1264 Sample Evaporation Instruments 1325 Sample Master 16 Sample preparation automation 2068 Sample preparation devices 144, 1611 Sample preparation reagents 368 Sample storage systems 634 Sampling Device 705 Sanitary pumps 89 Satumomab pendetide 870 S. aureus vaccine 1950 Scale-up purification & biotransformation of lead compounds 1946 Scanning imaging systems 2489 Scanning Photon-Counting Fluorometer 741 Scanning Probe Microscope 940, 1908 Scanning UV/VIS Spectrophotometer 1576 Scientific/clinical instruments 1126 Scientific lab 1765 Scientific software 1448, 1593, 1899

981

Scientific software computer programs 485 Scientific software for life science research 2058 Sci Works Data Manager 889 SCP-1 for postsurgical pain 2634 Screen breath alcohol tubes 932 Screening librarie 376 Screen Max plasmid mini-prep test 2929 Screen profile 932 SCV-07 2494 Seal Force Monitor 1193 Secondary antibodies 1068 Secondary antibody coated microspheres 288 Secondary contained piping system 2196 Securi-jet 355 Securiprint 355 Sedative hypnotics 645 Seed culture 403 Seed microbial inoculation 1599 Seed plant breeding true 1599 Seed plant cultivate 403 Segment of HIVp17 proteins 2866 Select biochemistry analyzer 2945 Selection Antibiotics 1537 Self clean cycle devices 1830 Self-priming centrifugal pump 1143 Self vaccinating devices 969 Semen Analysis Kits 1352 Semisynthetic natural product 145 Sense mRNA therapy 2535 Sensitive conjugate for blotting and immunoassays 2423 Sensors for biotechnology 195 Separating column 1078 Separation and purification columns 779 Separation devices 1879 Separation process equipment 797 Separation-reaction-separation technology 1078 Separations media 936 Separation systems for drug development 145 Separator 1078, 2909 Separatory funnel shakers 995 Sepragels 1494 Seq-to-Clone Gene Expression 1001 Sequence analysis softwares 1205, 1343 Sequence Detection System 2193 Sequence gels 546

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Sequencing enzymes 1117 Sequencing reaction clean up 1001 Sequenzer 547 Sera and cell culture reagents 1305 Sera and reagents 545 SeraSub 841 Series Microplate ELISA Readers 615 Series Microplate Fluorometer 615 Series Microplate Luminometers 615 Series of Serine Protease Inhibitors 690 Series Optical Scanners 615 Serine protease inhibitors 1055 Serotonin receptor agonists 95 Serotonin transporter Mab 1742 Serum-and protein-free CHO system 138 Serum antibody EIAs 1559 Serum free and protein free powdered tissue culture media 664 Serum-free cell culture media 375 Serum free media 545, 682, 1544 Serum Free Media for Osteoclast 2378 Serum-free, protein-free media 1589 Serum Protein Immunoassays 1597 Several bioactive novel peptides 283 SGN-00101 HspE7 2650 Shaker-Mixer blender 1264 Shakers 1263 Shaking incubators 559 Shim-pack XR Series of HPLC columns 2560 Shingles vaccines 1826 Shotgun library construction kits 2537 SIB-1508Y (Parkinson’s disease) 2564 Side pack columns 550 Signal transduction antibodies 489 Signal transduction inhibitors 212 Signal transduction kits 431 Signal transduction reagents 430, 544 Signal transduction receptor 319 Signal transduction research tools 399 Silage inoculant 1191 Silanized glassware sterile containers 991 Silicone cell culture growth bags 2703 Simatic process control system 2565 Simulation tool for modeling separation of macromolecules 979 Single and multichannel pipettors 2826

Single beam spectrophotometer 2708 Single cell proteins 130, 266, 549, 607, 1050, 1159, 1460, 1705, 2313, 2323, 2964 Single cell proteins antibiotics 467 Single-chain antigen-binding proteins 1052 Single channel pipettes 1391 Single component chromogenic substrates 2518 Single-strand DNA 871 Single strand DNA preparation kit 1644 Sinu-Clear 828 Sitaxsentan 1380 “site active” corticosteroid drug 2230 Site Directed Mutagenesis kits 2361 Site-specifically modified protein analogues 1286 Site specific cell cultures 675 Skin application gel 635 Skin melanoma preventative 2814 Skin model 1774 Skin Permeation Enhancer 2701 Skinpro feminine gel 725 Skinpro lotion 725 Skin resurfacing laser 671 Skin whitener 2814 Slide Micro hybidization Kit 2493 SlideMoat in-situ hybridization incubator 559 Slide thermocycler 1197 Sliuttlestop 1553 Slow speed rockers 559 Small molecular anticarcinogen 156 Small molecular anticytokine agent 156 Small molecular drug candidates 919 Small molecular drugs 1831 Small-molecule combinatorial chemistry 475 Small molecule compound libraries 794 Small molecule, drug-like compounds 2211 Small-molecule drugs 212, 238, 2298 Small molecule nucleoside analoges 1164 Small molecule organic compound 794 Small molecule organics 2104 Small molecule pharmaceuticals 941 Small molecule therapeutics 1775, 2089 Small organic molecules 261 Small organic molecules/therapeutic DNA binding drugs 2348 Small peptides 2574

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Keywords Index Small scale fermentation 1479 Small scale purification 1293 SmartTM M195 (HuM195) 2339 Snake Venom Proteins 690 SNP/CNV Chip 1401 SNP Frequency Database 2533 Sodium channel blocker 776 Sodium hyaluronate 523 Soft capsules granulator 1580 Soft tissue patches 440 Software for batch process control 787 Software for bioinformatics 845 Software for biotech medicines research 273 Software for carbohydrate analysis 1275 Software for DNA sequencing 1173 Software for DNA synthesis 1173 Software for genetically engineed drugs 2360 Software for immunoassays 570 Software for molecular biology and genomics research 1227 Software for pharmaceutical development 1365 Software for scientific instruments 893 Software package 1449, 1706, 2633, 1795 Software solution for accelerating drug discovery 1383 Software/Workstation 1024 Soil Treatment System 542 Soil water sensor 1981 Sol-gel technology 2592 Solid cell culture medium 332 Solid matrix seed priming 1599 Solid Phase Biotreatment 542 Solid phase extraction cartridges 1563 Solid phase sequencing of nucleic acids 2533 Solid phase synthesis supports 2270 Solid state CCD cameras 2357 Solid-state fluorimeter 2801 Solid-state genome mapping technology 377 Solid supported reagents 773 Solid supports for synthesis 477 Solid tumor model 1195 Soluble paclitaxel derivatives 301 Solutions, mixtures and chemical kits 722 Solvent evaporation equipment for drug discovery 1218 Solvents for biotechnology medicines 2400

983

Somatic cell hybrid panels 484 Somatic cell hybrids 813 SOMATOKINE 1475 Somatostatin analogs 320 Somatostatin calcitonin 2803 Somatropin 523 Somavert 2209 Sonifilan 1594 Sorbent matrices for preparative chromatography 550 Sound sleep Sublingual 312 Southern Soxhlet apparatus 144 SP501 1519 Specia chemicals 362, 167, 1080 Special delivery cytosolic delivery system 1211 Special intermediates 2296 Specialist cell culture media 1269 Specialist software 726 Specialized antisera and disease state plasma 668 Specialized cell culture reagents 396 Specialized detergents 1297 Specially chemicals 1160 Specially cleaned containers 2503 Special pig arteries and veins 834 Specialty amino acids 2682 Specialty animal feed ingredients 711 Specialty biochemicals 79, 80, 980, 1185, 1310, 1605, 2148, 2426 Specialty chemicals 35, 54, 182, 221, 266, 298, 367, 405, 421, 467, 504, 593, 598, 710, 717, 718, 847, 886, 926, 1026, 1029, 1036, 1050, 1055, 1063, 1075, 1104, 1108, 1460, 1506, 1532, 1549, 1584, 1649, 1705, 1709, 1758, 1782, 1792, 1812, 1813, 1841, 1865, 1893, 2648, 2772, 2923 Specialty chemicals, reagents 2727 Specialty compounds in microplates 1866 Specialty enzymes 111, 1523, 2820 Specialty growth media 1250 Specialty microarray 2934 Specialty neurochemicals 74 Specialty oils in plant seeds 599 Specialty organic compounds 1621 Specialty protein 2 Specialty reagents 2247 Specialty sera 342

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Specialty starch corn 1074 Specialty tools 1306 Specific affinity absorbents 452 Specifically biosensors 473 Specific antisense oligonucleotides 1359 Specific binding agents of human angiopoietin-2 132 Specific HPLC detector 170 Specific immunoassays 229 Specific MRNA isolation kit 1463 Specimen collection kits 1215 Spectral Red reagerrts 2606 Spectrofluorometer 271, 1488 Spectrophotomer 2710 Spectrophotomer cell 2618 Spectrophotometer 1577, 2040 Spectrophotometer cells 1327 Spectroradiometer 144 Speedlight gel documentation system 585 Sperm genetics 1151 Sperm separation materials 1151 Spherical silica 584, 1147 Spiriva HandiHaler 558 Spodotrol 1142 Spray dryers 2021 Sprcialty chemicals 1293 ß-Lactamase inhibitors 2678 Stability test chambers 1737 Stabilized protein crystals 109 Stabilized protein crystals formulations 109 Stable isotope labeled compounds 611 Stable isotopically-labeled carbohydrates 2080 Stainless steel component product line 299 Stainless steel equipment 2248 Stainless steel storage equipment 894 Standardized assays for gene expression analysis 1178 Standardized gene expression analyzer 1178 Star-burst dendrimer 905 Star Fish™ chromosome paints 608 Starts-up system in biotech industries 1309 Stationary phases cell 733 StatLIA® workflow and analysis 570 STD kits 2486 Steam sterilizers 1292 Stem cell 1367

Stem cell concentrator 670 Stem Cell Culture Status Profiling 1063 Stem cell enrichment device 904 Stem cell factor compositions 132 Stem cell growth factor 2688 Stem Cell Media 1880 Stem cell transplant 2007 StemSpan H200 2640 Steriguard bench-top sterilizer 1467 Sterile air/gas filters 961 Sterile antibiotic mixtures 137 Sterile biopharmaceuticals 727, 811 Sterile connector system 40 Sterile donor animal cell cultu media 2374 Sterile filling devices 2004 Sterile filter tips 547 Sterile medical devices 1865 Sterilization-disinfection devices 228 Sterilization filter 1111 Sterilization of biological waste 2026 Sterilizers 1188, 1347 Steroid chemistry reagents 461, 1592 Steroid drugs 1133 Stirred tank fermentation equipment 1730 Stirrers 1263 Strains of bacteria, yeasts and fungi 316 Streptococcus pneumoniae gene 1016 Structural-Bank 2652 Structural Biology Industry Platform 363 Structure-based drug molecular modeling 2458 SU101 2655 SU5416 2655 Subgingival antibiotic therapy 245 Submarine electrophoresis system 1008 Subtractive amplification 1189 Subunit Vaccine 1382 Sucrose phosphate synthase 599 Suffer gas analyser 744 Sunitinib malate 2205 Super™Clean Miniprep System 955 Supercool devices 2661 Supercritical fluid extraction instrument 194 Supercritical fluid extraction systems of TCMM 1964 Supercryogenic refrigerator 153 SuperHyb Kit 1911

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Keywords Index Super™ Hybridization Buffer System 955 Super™ Immunoblotting System 955 Super Sequencer 2548 SuperSignal® substrates 2247 Supplemental serums 2760 Support immunobilized enzymes 1787 Support reagents for researchers 2952 Supports for immobilized metal affinity chromatography 742 Suppression PCR 768 Surface modification and immobilization reagents 581 Surgam 2459 Surgical adhesives & sealants 2342 Surveillance Network 1933 Swinevaccines 2685 Swiss-2D database 1217 Swiss-Prot Database 1217 Symmetrical multiple antigenic peptide systems 2677 Synovir 657 Synthesis of blocked free and tagged Multig Medium Sized Peptides u11 2265 Synthesis platforms 793 Synthesizer Columns 2710 Synthesizer for combinatorial chemistry 644 Synthetic antibody library technology 393 Synthetic blood 2476 Synthetic carbohydrates 425 Synthetic cytokines 505, 506 Synthetic DNA 506, 1550 Synthetic DNA and DND detection 2683 Synthetic genes 1039 Synthetic microchromosome vector system 239 Synthetic oligonucleotides 2119 Synthetic oligos 952 Synthetic organic chemistry 789 Synthetic peptide coated microcarrier beads 2596 Synthetic peptide libraries 1601 Synthetic peptides 506, 1409 Synthetic vaccines and antibody therapeutics 881 Syringe & Mkrofuge filters 580 Syringe burette 2404 Syringe filter 1628, 2251, 2481 Syringe filter separation devices 580 Syringe Pump 647, 1628

985

System for activated sludge management 346 System for DNA analysis 2360 Systemic IGF 247 Systems for chiral separation 2738 Systems for drug delivery 2637 Sytakines 1520 Tabletop centrifuges 798 Tag assay for gene function discovery 2249 Tag polymerase 1106 TA-HPV 625 TA-HSV 625 Taq DNA Polymerase 2454 Tarceva (Erlotinib Hydrochloride) 2114 Targeted gene therapy 2751 Targeted protein affinity ligands 2329 Targeted ribozymes 795 Target gene discoveries 2463 Targeting gene separation technology 2799 Target Progesterone Test Kit 420 Target seguence of duplex DNA 1062 Taxane Immunoassay kit 1313 Taxol 866, 1074 Taxol Immunoassay kits 1313 T cell activation inhibitors 259 TC grade fetal bovine serum 400 TCMM diagnoslic instruments 2562 TCM Therapists-Acupuncture and Massage Therapy System 2556 TC mycoplasma detection kit 1544 TCR Peptides 804 Techniques for high throughput genetic sequence analysis 1062 Technologies of combinational and medicinal chemistry 698 Technology for biological pathway drug discovery 845 Technology for gene discovery 845 Technology for reproduction test 2421 Technology of drug design 2369 Technology R&D platform 1483 Technology transfer bioproducts 371 Technology transfer of bio pharmaceuticals 1243, 2397 Technology transfer of biotech medicine 290 Technology transfer of gene drugs 1214

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Techtide 934 Teduglutide (ALX-0600) 1931 Teflon culture systems 123 Teiomerase Phage Therapy inhibitors 446 Telemedicine system for pathology 557 Telemedicine systems 1812 Temperature and vacuum controllers 1487 Temperature inducible expression system 877 Temperature sensitive gene 2495 Temperature sensor 291, 1615 Temporary skin culture grafts 46 Terminal transferase 1117 Testing kit for genotoxicity 1047 Testing kit for mutagenicity 1047 Testing kit for toxidity in sediments 1047 Test Kit for bladder cancer 1771 Test kits and components 1797 Test kits for drugs of abuse 1817 Test kits for GM food detection 1114 Testosterone Gel 663 Tests for bile duct damage in humans 541 Tests for monitoring of pig xenotransplants 541 TGF-beta3 2114 TGF-beta receptors 1474 Thalidomide 1043 Therafectin 564 Therapentics of prostate cancer 1232 Therapeutic agents for Hepatitis B&C 2674 Therapeutical drugs 689 Therapeutical drugs for cancer 749 Therapeutical drugs for CNS 688 Therapeutic biopharmaceuticals 1128 Therapeutic drug for cancer 441 Therapeutic drug for Rhinovirus 511 Therapeutic drugs 276, 972, 2889 Therapeutic drugs for diseases of CNS 1997 Therapeutic enzyme drug 1372 Therapeutic grade peptides 261 Therapeutic grade protein 915, 1009 Therapeutic human monoclonal antibodies 609 Therapeutic injection molding 1302 Therapeutic liposome compositons 2536 Therapeutic Mabs 881 Therapeutic monoclonal antibodies 805 Therapeutic products 160, 677, 1726, 1727

Therapeutic proteins in transgenic birds eggs 2888 Therapeutics based on tumor suppressor genes 623 Therapeutics for Alzheimer 1416 Therapeutics for cancer 2544 Therapeutics for CNS diseases 378 Therapeutics for Diabetic 2438 Therapeutics for ion channel 1375 Therapeutics for tumors 906 Therapeutics from antisense nucleic acids 1051 Therapeutics of late onset degenerative diseases 1888 Therapeutic target selection 48 Therapy monitoring neuronal networks 534 Theratope 425, 426 Thermal Analysis Systems 231 Thermal cyclers 382, 547, 1203 Thermal cycling instruments 1325 Thermal instruments for robotics 1325 Thermal management systems for cell 2902 Thermal mass flow controllers 1046 Thermal stable enzymes 1919 Thermastable PCR enzymes 517 Thermocyclers 1246, 1732 Thermolabile phosphatase 1056 Thermometric instruments 1398 Thermophilic microorganisms 73 Thermostable DNA polymerase 422, 1175 Thermostable enzymes 2382, 2755 Thermostable Enzymes and Reagents 537 Thermostatic baths 821 Thermotrace 902 Thin-layer chromatography scanner 142 ThinPrep® Pap Test 884 Thiocolchicoside 1439 Three anticancer monoclonal antibodies 1811 Thrombin inhibitor 1698, 2176 Thrombolytic-novel chemical 2126 Thrombolytics 466 Thrombolytic therapy monitoring assays 633 Thrombus agent 1061 Thrombus specific ultrasound contrast agent 1405 Thruput Ion Exchange resins 2644 Thyroid peroxidase 1123

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Keywords Index Thyrotropin alpha for injection 1248 Ticiclmumab 2205 Time Manager Software 988 Time-of-flight mass spectrometer 800, 1638 Tinea corporis and tinea cruris 725 Tipranavir 558 Tissue analysis 2768 Tissue and cell culture reagents 2795 Tissue bank 264 Tissue/cell culture supplements 1501 Tissue choppers and slicers 1013 Tissue culture 1641, 1891, 2016 Tissue culture grade serums 1568 Tissue culture media 1659 Tissue culture plastic ware 1874 Tissue culture rooms 810 Tissue culture system 949 Tissue culturing systems 1703 Tissue dissociation enzymes 2924 Tissue Engineered Bone 1553 Tissue factor pathway inhibitor 734 Tissue file boxes 634 Tissue grinder 949 Tissue healing scaffolds 2752 Tissue homogenizer 493 Tissue or cell culture 1137 Tissue Processor 1951 Tissue-vectors specific replication 1207 Title inhibitors of urokinase 820 TLC apparatus 1755 TLC plates 1755 TNF kits 1362, 2472 TNF-PEG 866 TNF2 Receptor antagonist 1923 TNT inhibitor 2475 Tocilizumab 2452 Tomato 1157 Tomudex 583 Tongren Dahuoluo wan 730 Tongren Niuhuang Qingxin wan 730 Tongren wuji Baifeng wan 730 Tools for drug discovery 2420 Tools for gene delivery 1537 Tools for gene therapy 2321 Tools for genomics and proteomics research 2326

987

Tools to support drug discovery 2593 Topical anti-fungals 1132 Topical antiinflammatory-OAS 1000 2117 Topoisomerase 1872 Tositumornab and iodine I 131 tositumornab 822 Total cholesterol test 1053 Total cholesterol to HDL ratio test 1053 Total Fluoride Analyzer 170 Total organic carbon analyzer 149 Tovaxin 2094 Toxic cyclic peptide 1355 Toxi Chromotest 1047 Toxicity test kits 100, 1889 Toxicological diagnostics kits 2886 Toxicology software 1176 Toxicosozin 1355 Toxic waste processing method 1309, 2443 Toxic waste processing system 744, 847, 896, 967 Toxic waste processing technique 2429 Toxin therapeutics 695 Toxoplasma recombinant antigens 1125 Trace diagnostics reagents 2782 Trace DNA detection kits 138 Traditional Chinese medicinal material 1346 Transdermal Drug Deliveries 2226 Transdermal Glucose 2711 Transdermal patch delivery systems 110 Transfection reagents 1886 Transferpette™ single and multichannel pipettes 568 Transferrins 1877 Transformation Kits 638 Transgenic animal 246 Transgenic animal models of human disease condition 2218 Transgenic animal models of human disease condition 2219 Transgenic animal modul 2877 Transgenic animals 745 Transgenic BioSteel 2008 Transgenic breeding animal 356 Transgenic crops 2253 Transgenic fish 201 Transgenic fishs 61 Transgenic fruit 973

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Transgenic human CD4 rabbit 2625 Transgenic mouse model of Type II (noninsulindependent) diabetes 957 Transgenic plant breeding 289 Transgenic plants 262, 285 Transgenic potatoes 384 Transgenic release site 1172 Transgenic varieties 2524 Transgenic workstation 1065 Transgenome 1607 Transiluminatories 1127 Transmitters 589 Transposon Tools 1056 TranSwitch Gene Suppression 439 Travellers’ diarrhea vaccine 274 Treatment targets 84 Trecetilidefumarate 2209 Trichoderma enzyme complex 983 Triglycerides test 1053 Tripedia 802 Triphosphate analogs 399 Triptorelin 895 Tromsframe proteins 2246 True Human Serum 1509 True potato seed 1074 Tryptase 818 Tubersol 802 Tumor Derived Activated Lymphocyte Cells for the treatment of cancer 620 Tumor marker 353 Tumor Marker Elisa 1581 Tumor marker panel control 1 Tumor Markers ELISA 762 Tumor marker tests 1516 Tumor necrosis factor antibodies 2183 Tumor-specific antigen 491 Tumor suppresor gene antibodies 2086 Tumor suppressor gene diagnostics 623 Tumor therapeutics 1248 Tumor vaccine 1808 Turbidity Meter 456 Turbomolecular 2204 Tvastuzumab (Herceptin) 1186 Two & One Hybrid Technology 1895 Two new members of the FGF-beta family 448

Two-phase Pipette Filter 1063 Two-stage closed system 73 Two stage homogenizer 266, 297, 2083 Tylosin 284 Type II collagen assay 2118 Type II Collagen Capture Kit 737 Typhidot 1751 Tyrosine kinase substrate proteins 2655 Tysabri (Natalizumab) 381 UF/MF membranes for Lab/piot/process-scale use 2139 U-Genes uracil DMA glycosylase 982 Ultrabred crop 2483 Ultracentrifuge tubes 2546 Ultra clean stainless furnishings 2052 Ultra DNA Fectomine 955 Ultrafast microprotein analyzer 1585 Ultra-Filtration Skids 1625 Ultrafiltration systems 2492 Ultra/High Performance centrifugues 1457 Ultra high purity fluid/gas delivery systems 52 Ultra high yield transcription kits 116 Ultra low temperature freezers 1588, 2001 Ultra-low temp freezers 2757 Ultra/micro filtration equipment 1999 Ultra micro volume cells 1327 Ultra pure avidin 1513 Ultrapure Bioreagents 1752 Ultrapure bovine hemoglobin 460 Ultrapure enterokinase 548 Ultrapure water systems 1015 Ultramicrotome knives 1306 Ultrasensitive colorimetric assays 1007 Ultra-small molecules drugs to inhibit AIDS 662 Ultrasonic cell disintegrator 1664 Ultrasonic cleaner 1664 Ultrasonic Cleaners; Automated Titration System; Thermal Analyzers 1755 Ultrasonic cleaning unit 569 Ultra sonic disrupters 2717 Ultra stable enzymes 207 Ultra Thin DNA Sequencer 2603 Ultra thin gel electrophoresis apparatus 1227 Ultrathin gels for diagnosis 322 Ultraviolet-visible detector 205

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Keywords Index Unique-sequence DNA 42 Uni-sep tubes for lymphocyte separation 2041 Universal Automation Platform 2962 Universal Genetools for drug discovery/validation 2474 Universal Medical Information Computer Systems 979 Universal self-retracting lancing device 2135 Unscrambler 617 Upstream and downstream processing 1027 Up-stream expressing sequence 1656 Urine assay for bladder cancer 1771 UriSub 841 Urokinase 831 UV light sterilized sampling device 1403 UV-to-Visible, Light Converter 2805 UV-VIS 1326 UV/VIS/NIR Spectrophotomers 1570 UV-Vis Spectrometer (on-line) 720 Vaccination systems 887 Vaccine adjuvant for allergic reaction 814 Vaccine adjuvant treat infectious disease 814 Vaccine delivery system 883, 2568 Vaccine for equine herpes 1693 Vaccine for hepatitis 1181 Vaccine platform 338 Vaccines 270, 302, 402, 447, 466, 470, 471, 476, 515, 525, 549, 577, 623, 678, 703, 716, 717, 721, 727, 738, 753, 760, 780, 789, 807, 823, 842, 856, 859, 913, 923, 974, 977, 987, 989, 1002, 1003, 1009, 1024, 1067, 1076, 1135, 1146, 1152, 1160, 1277, 1322, 1329, 1334, 1336, 1346, 1354, 1356, 1374, 1477, 1504, 1532, 1557, 1584, 1705, 1740, 1758, 1780, 1781, 1792, 1812, 1873, 2736, 2773, 2838 Vaccines for anthrax and botulism 2280 Vaccines for cultured shrimp 1868 Vaccines for the prevention of human infectious diseases 2029 Vaccines reagents 248 Vaccine strain 2632 Vaccine therapy 1641 Vaccinetherapy 2632 Vaccine to treat hepatitis A virus 1294

989

Vaccinia virus expressing carcinoembryonic antigen 171 Vaccinia virus expressing carcinoembryonic antigen 2753 Vaginal Antifungal Pessary 687 Vaginal gel 503, 1290 Vaginal health product 1290 Validated antigen targets 2825 Validated targets 1630, 2663 Validation of robotic processes 1064 Validator Software 1603 Value-added agricultural products 965 Vanadate 158 Vapor Master Filter 1072 Variable temperature cryostats 153 Varicella zoster immune globulin 622 Variety selection of crop plants 1274 Various Gene Therapies 1528 Vascular grafts 2746 Vascular prostheses 440 Vasoactive intestinal peptides 146 Vasofem for female sexual dysfunction 2965 Veccines 374 Vector for polypeptide translocation 387 VEE GEE Brand Thermometers 2849 Vegetable drugs 1579, 1680 Vegetable proteins 494 Vegetable seeds 2954 VEGF 121 1244, 2508 Vehicles for the targeted delivery of drugs 1405 Velcade (Bortezomib) 1879 Vepalimomab/monoclonal antibody 533, 535 Vertical and horizontal electrophoresis instruments 422 Veterinary biologicals 851 Veterinary diagnostic assays 461 Veterinary diagnostic kits 2750 Veterinary diagnostics 1288, 2891 Veterinary diagnostic test kits 517 Veterinary drug 1663 Veterinary drug products 2614, 2631 Veterinary drugs 780, 1592 Veterinary healthcare drugs 161 Veterinary medical consumer products 2920 Veterinary products 179, 1395, 2900 Veterinary Software 1387

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Veterinary vaccines 380, 786, 924, 926, 959, 2496 V21 for treatment of cardiovascular disease 1272 Viastem 682 Vibrating Mixers 456 Victor Multi-Label Reader 2194 Video image analyzer 557 Viprinex 1991 Viral antigens 1513 Viral attachment proteins 1334 Viral capture 1712 Viral Detection Kits 537, 1525 Viral diagnostic novel agents 180 Viral polymerase inhibitor 558 Viral removal membranes 75 Viral Respiratory Kit 292 Viral therapeutics 139 Viral therapeutics to target prostate cancer 605 Viral vaccine 1808 Viral vector design and optimization 465 Viral vectors 1234, 1909 Viral vectors for gene therapy 1335 Virtual design software packages 364 Virtual drug screening 2653 Virulizin 1728 Virus absorption removal filter 218 Virus Inactivated reagents 2133 Virus models for purification process validation 2869 Virus-safe factor VIII 1300 Virus transport 1334 Virus vector 443 Viscometers 1260 Visudyne 2368 Vitaxin 1562 Vitravene 1548 Vrrend antiviral 2552 Washable seamless clean room 757 Washer for industry equipment 1676 Waste biodegradation 2664 Waste sterilization systems 217 Water and waste water treatment/equipment 896 Water Flow Monitors 1487

Water parasite and food pathogen detection 985 Water Purification 1880 Water purification systems 1203, 1652 Water purification treatment devices 1341 Water quality analyzers 1788 Water Quality Monitoring Instruments 1546 Water soluble biotins 1903 96 well filter bottom microplates 2913 Well Multi-Tier Microliter Plate 526 Well PCR purification 2720 Well Plate 1209 96 Wells plates with special surfaces 408 Wescor Macroduct 946 Western Blot 1059 Western blot strips for Lyme 148 White blood cells for gene therapy 2747 White Spruce Hybrids 1134 Whole band match analyzer 1229 Whole blood filter 206 Whole blood immunoassays 633 Whooping cough vaccine 2280 Windows-Based Validation System 1603 WinRho SDF 621 Wisconsin package for Sequence Analysis 1205 Women’s healthcare products 884 Women’s health care vaginal lactobacillus suppository 740 Women special drugs 1290 Workbench and data acquisition systems 1614 Wound and skin cleanser 639 Wound dressing 332 Wound healing 752 Wound, skin, tissue engineering products 758 Xanthan gum 1825 Xenograft 2289 Xenograft transplantation system 540 Xenorhabdus TC gene for pest control 965 Xeno transplant 415 XERECEPT 1991 X-glucuronide 1273 Xinshu bao pian 2958 X-L-iduroniadase 404 X-ray Imaging Systems 2461

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Keywords Index X-stream low temperature device 1913 Xylanase 284, 315 Xylanase enzyme 517 Yaotongning capsule 724 Yeastcidin 1233 Yeast medium 664 Yeast Test 951 Yellow fever vaccine 2100, 2184 Yufeng Ningxin Pian 730

Yunnan Baiyan tinctura 2946 Yunnan Biayao capsule 2946 ZADAXTN® thymosin alpha 1 2494 Zaizao wam 730 Zanaflex (tizanidine) 236 Zenapax® (daclizumab) 2339 Zinecard 583 Zintevir 214 Zybrestat 2129

991

INTERNATIONAL COMPLETE COLLECTION OF R&D INFORMATION ABOUT TRADITIONAL CHINESE MATERIA MEDICA AND BIOTECHNOLOGY ENTERPRISES This volume is designed as an informative medicinal reference directory listing up-to-date R&D information about TCMM, medical biotechnology, and related medical equipment companies. The focus of this valuable and practical directory is on providing a comprehensive coverage of the most recent developments in scientific research, patents and major products of about 3,000 companies from 50 countries covering the five continents: Asia, Europe, America, Africa and the Oceania. The resource material and information are relevant and compulsory to practitioners and professionals in the fields of TCMM, medical biotechnology, biochemical industry and related medical instrumentation/equipment, as well as to organizational departments of the medicinal information management, intelligence, logistics and trade. The directory also serves as an important window through which biotech professionals master product information of their counterparts across the world. The directory will benefit professionals of medical heath, TCMM, biotechnology and related fields, as well as academics and students, executives of research, information media staff and translators.

World Scientific

ISBN-13 978-981-4291-56-9 ISBN-10 981 -4291 -56-0

www.worldscientific.com 7557 he

9 "789814 291569" I